keyword
https://read.qxmd.com/read/38530541/ginsenoside-rb1-deters-cell-proliferation-induces-apoptosis-alleviates-oxidative-stress-and-antimetastasis-in-oral-squamous-carcinoma-cells
#1
JOURNAL ARTICLE
Le An, Yang Yu, Long He, Xu Xiao, Pengcheng Li
There are numerous therapeutic applications for ginsenoside Rb1 (GRb1), the primary saponin derived from ginseng root. According to earlier research, ginsenoside Rb1 causes apoptosis and reduces the cell cycle. Its adverse effects, especially those on the development of the embryo, still need to be thoroughly studied. A host's lifestyle choices, including smoking, drinking too much alcohol, using tobacco products, and having an HPV infection, can increase the risk of oral squamous cell carcinoma (OSCC), one of the most prevalent malignancies of the oral cavity...
March 26, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38524276/adult-harm-perceptions-purchase-and-use-related-to-synthetic-vs-tobacco-derived-nicotine-vaping-products-a-mixed-methods-study
#2
JOURNAL ARTICLE
Artur Galimov, Adam M Leventhal, Josef Hamoud, Leah Meza, Jennifer B Unger, Jimi Huh, Lourdes Baezconde-Garbanati, Steve Sussman
OBJECTIVE: Synthetic nicotine (SN) e-cigarettes emerged on the market as an alternative to tobacco-derived nicotine (TDN) vaping products. It is critical to understand the harm perceptions, purchase, and use of SN vs. TDN e-cigarettes. METHODS: From November 2021 to February 2023, we conducted intercept interviews with 263 adult customers at 37 vape shops in Southern California. Self-reported use and harm perceptions towards SN vs TDN e-cigarettes were examined...
May 2024: Preventive Medicine Reports
https://read.qxmd.com/read/38503267/cigarette-smoking-and-e-cigarette-use-induce-shared-dna-methylation-changes-linked-to-carcinogenesis
#3
JOURNAL ARTICLE
Chiara Herzog, Allison Jones, Iona Evans, Janhavi R Raut, Michal Zikan, David Cibula, Andrew Wong, Hermann Brenner, Rebecca C Richmond, Martin Widschwendter
Tobacco use is a major modifiable risk factor for adverse health outcomes, including cancer, and elicits profound epigenetic changes thought to be associated with long-term cancer risk. While electronic cigarettes (e-cigarettes) have been advocated as harm reduction alternatives to tobacco products, recent studies have revealed potential detrimental effects, highlighting the urgent need for further research into the molecular and health impacts of e-cigarettes. Here, we applied computational deconvolution methods to dissect the cell- and tissue-specific epigenetic effects of tobacco or e-cigarette use on DNA methylation (DNAme) in over 3,500 buccal/saliva, cervical, or blood samples, spanning epithelial and immune cells at directly and indirectly exposed sites...
March 19, 2024: Cancer Research
https://read.qxmd.com/read/38496069/tobacco-free-nicotine-pouches-and-their-potential-contribution-to-tobacco-harm-reduction-a-scoping-review
#4
REVIEW
Erika Grandolfo, Henry Ogden, Ian M Fearon, Layla Malt, Matthew Stevenson, Sarah Weaver, Thomas Nahde
Tobacco harm reduction (THR) refers to strategies designed to reduce the health risks associated with tobacco smoking but may involve continued use of nicotine and/or tobacco. Next-generation products (NGPs) are a THR alternative as they do not burn tobacco or produce smoke and deliver nicotine and have fewer and substantially lower levels of harmful chemicals compared to cigarettes. Tobacco‑free nicotine pouches (TFNPs) are an emerging category of nicotine‑containing oral products that do not combust or contain tobacco leaf...
February 2024: Curēus
https://read.qxmd.com/read/38485233/industry-responds-to-australia-s-disposable-vape-import-ban-with-cheap-alternatives-and-encouraging-illegal-imports
#5
JOURNAL ARTICLE
Coral E Gartner
No abstract text is available yet for this article.
March 14, 2024: Tobacco Control
https://read.qxmd.com/read/38475757/a-randomized-controlled-trial-of-potential-tobacco-policies-prohibiting-menthol-flavor-in-cigarettes-and-e-cigarettes-a-study-protocol
#6
JOURNAL ARTICLE
Krysten W Bold, Akshika Sharma, Angela Haeny, Ralitza Gueorguieva, Eugenia Buta, Stephen Baldassarri, Lauren Lempert, Suchitra Krishnan-Sarin, Stephanie O'Malley
BACKGROUND: Menthol cigarette use remains a large public health problem and disproportionately affects Black adults in the United States. The Food and Drug Administration has proposed prohibiting menthol flavor in cigarettes to protect public health. However, e-cigarettes are available in menthol flavor and are a popular alternative product adults might switch to if menthol is prohibited in cigarettes. Research is needed to understand how availability of menthol (vs. tobacco) flavored e-cigarettes could impact cigarette use among adults who smoke menthol cigarettes...
March 12, 2024: BMC Psychiatry
https://read.qxmd.com/read/38469105/prevalence-and-associated-factors-related-to-tobacco-consumption-among-university-students-in-malaysia
#7
JOURNAL ARTICLE
Chui Yi Chow, Md Zobaer Hasan, Anton Abdulbasah Kamil
Tobacco consumption is one of the major public health concerns worldwide. Moreover, alternative tobacco and nicotine products (ATNPs) are growing in popularity, especially among young adults in the past decade. The study aimed to determine the prevalence and associated sociodemographic factors of tobacco consumption among university students. A cross-sectional study was carried out among 338 university students of a private Malaysian university from March to April 2021. Data was collected using a self-administered online questionnaire with items including sociodemographic information, user status of tobacco consumption and types of tobacco product used...
2024: Health Psychology Research
https://read.qxmd.com/read/38459919/tobacco-policy-in-coherence-in-mozambique-an-examination-of-national-and-subnational-stakeholder-perspectives
#8
JOURNAL ARTICLE
Nicole Nguenha, Charo Rodriguez, Jeffrey Drope, Stella Aguinaga Bialous, Benedito Cunguara, Raphael Lencucha
Mozambique ranks fifth on the list of tobacco producing countries in Africa, while also being a Party to the WHO Framework Convention on Tobacco Control (FCTC). Tobacco farming is regarded by some governments as a strategic economic commodity for export and remains deeply entrenched within Mozambique's political and economic landscape. This study uses a qualitative description methodology to identify tensions, conflicts and alignment or misalignment in policy on tobacco across government sectors and levels in Mozambique...
February 28, 2024: Health Policy and Planning
https://read.qxmd.com/read/38447971/tobacco-usage-in-the-home-a-cross-sectional-analysis-of-heated-tobacco-product-htp-use-and-combustible-tobacco-smoking-in-japan-2023
#9
JOURNAL ARTICLE
Satomi Odani, Takahiro Tabuchi
BACKGROUND: Heated tobacco product (HTP) use continues in Japan as the second most common product after cigarettes. While the health effects of HTPs and their secondhand emissions are not well-studied, the tobacco industry has actively marketed HTPs as a smokeless, health-conscious alternative to cigarettes to encourage home consumption. We investigated the prevalence of current tobacco product use and usage at home. METHODS: The present study conducted a cross-sectional analysis of data from the 2023 wave of a nationwide, Internet-based, self-reported survey...
2024: Environmental Health and Preventive Medicine
https://read.qxmd.com/read/38447095/using-pod-based-e-cigarettes-and-nicotine-pouches-to-reduce-harm-for-adults-with-low-socioeconomic-status-who-smoke-a-pilot-randomized-controlled-trial
#10
JOURNAL ARTICLE
Jaqueline C Avila, Dale Dagar Maglalang, Nicole Nollen, Sangah Clara Lee, Riley Suh, Mona Malone, Urvi Binjrajka, Jasjit S Ahluwalia
INTRODUCTION: Alternative Nicotine Delivery Systems (ANDS) such as e-cigarettes (EC) and oral nicotine pouches (ONP) may facilitate the substitution of smoking for those unwilling to quit. This pilot study assesses the harm reduction potential of EC and ONP among smokers with low socioeconomic status (SES). METHODS: Adults who smoked daily in the past 6 months, had a household income < 250% federal poverty level and had no intention of quitting smoking in the next 30 days were randomized 2:2:1 to 8 Weeks of 5% nicotine EC; 4mg ONP or assessment-only control (CC)...
March 6, 2024: Nicotine & Tobacco Research
https://read.qxmd.com/read/38408200/reactions-to-a-hypothetical-ban-of-open-system-electronic-cigarettes-among-people-who-currently-use-electronic-cigarettes
#11
JOURNAL ARTICLE
Eric K Soule, Shannon Mayne, William Snipes, Mignonne C Guy, Alison Breland, Pebbles Fagan
INTRODUCTION: Policies limiting electronic cigarette (ECIG) device and liquid characteristics have been considered to prevent dependence potential and youth product appeal. "Open-system" ECIGs allow people to adjust device and liquid characteristics, which may undermine these policies. This study examined anticipated reactions to a policy prohibiting the sale of open-system ECIG devices in the United States using concept mapping. METHODS: In 2020, adults who reported ECIG use in the past 30 days (n = 70; 45...
February 26, 2024: Nicotine & Tobacco Research
https://read.qxmd.com/read/38393754/changes-in-oral-health-and-dental-esthetic-in-smokers-switching-to-combustion-free-nicotine-alternatives-protocol-for-a-multicenter-and-prospective-randomized-controlled-trial
#12
JOURNAL ARTICLE
Gianluca Conte, Sebastiano Antonio Pacino, Salvatore Urso, Doris Greiling, Pasquale Caponnetto, Eugenio Pedullà, Luigi Generali, Ugo Consolo, Vittorio Checchi, Stefan Gospodaru, Gheorghe Bordeniuc, Valeriu Fala, Jan Kowalski, Maciej Nowak, Renata Górska, Amaliya Amaliya, Iain Chapple, Michael Milward, Robert Maclure, Gianna Maria Nardi, Riccardo Polosa
BACKGROUND: Although the detrimental effects of conventional combustible cigarettes on oral health and dental esthetics are well known, there is limited information about the long-term impact of combustion-free nicotine alternatives (C-F NA) such as e-cigarettes or heated tobacco products. OBJECTIVE: This multicenter, prospective, 3-parallel-arm randomized controlled trial will investigate whether switching from combustible cigarettes to C-F NA will lead to measurable improvements in oral health parameters and dental esthetics over 18 months in adult smokers with limited gum disease...
February 23, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38393224/evaluation-of-cytotoxicity-and-oxidative-stress-of-whole-aerosol-from-vuse-alto-ends-products
#13
JOURNAL ARTICLE
Brian M Keyser, Robert Leverette, John Wertman, Tom Shutsky, Reagan McRae, Ken Szeliga, Patrudu Makena, Kristen Jordan
Assessment of in vitro cytotoxicity is an important component of tobacco product toxicological evaluations. However, current methods of regulatory testing involve exposing monolayer cell cultures to various preparations of aerosols from cigarettes or other emerging products such as electronic nicotine delivery systems (ENDS), which are not representative of human exposure. In the present study, a whole aerosol (WA) system was used to expose lung epithelial cultures (2D and 3D) to determine the potential of six Vuse Alto ENDS products that varied in nicotine content (1...
February 4, 2024: Toxics
https://read.qxmd.com/read/38392230/periodontal-health-status-in-adults-exposed-to-tobacco-heating-system-aerosol-and-cigarette-smoke-vs-non-smokers-a-cross-sectional-study
#14
JOURNAL ARTICLE
Ivana Mišković, Davor Kuiš, Stjepan Špalj, Aleksandar Pupovac, Jelena Prpić
UNLABELLED: Tobacco heating systems (THS) are new products on the market, advertised as a less harmful alternative for smokers, in which tobacco is heated and not burned like in conventional cigarettes. This research explored the effect on periodontal tissues in contact with heating and burning tobacco residual products (smoke and tobacco). METHODS: The sample included 66 subjects, patients of the Clinic of Dentistry in Rijeka, Croatia, aged 26-56 (median 38), 64% females...
January 29, 2024: Dentistry Journal
https://read.qxmd.com/read/38383153/public-support-for-tobacco-endgame-policies-in-south-korea-findings-from-the-2020-international-tobacco-control-korea-survey
#15
JOURNAL ARTICLE
Heewon Kang, Wonjeong Yoon, Hong Gwan Seo, Sungkyu Lee, Sujin Lim, Gil-Yong Kim, Su Young Kim, Steve S Xu, Mi Yan, Anne C K Quah, Janet Chung-Hall, Lorraine V Craig, Coral E Gartner, Geoffrey T Fong, Sung-Il Cho
BACKGROUND: Strong public support can increase the likelihood of adopting tobacco control policies. We assessed support for six commercial tobacco endgame policies in South Korea: limiting the nicotine in cigarettes, banning all additives in cigarettes, restricting the number of places where cigarettes are sold, and banning the manufacture and sales of cigarettes (unconditionally, with the provision of cessation support and with alternative tobacco products available). METHODS: Data were obtained from 4740 adults who completed the 2020 International Tobacco Control Korea Survey...
February 21, 2024: Tobacco Control
https://read.qxmd.com/read/38381598/exploring-mentholban-on-tiktok-a-thematic-and-semantic-network-analysis
#16
JOURNAL ARTICLE
Miao Feng, Steven Binns, Sherry Emery
INTRODUCTION: In April 2021, the U.S. Food and Drug Administration (FDA) announced its intention to ban the sale of menthol cigarettes and cigars. Decades of research support the premise a menthol ban will reduce initiation and disparities in tobacco-related disease among menthol smokers. The tobacco industry opposed such a policy and worked for decades to shape public opposition. Social media discourse can inform our understanding of public opinion about the proposed ban and guide communication strategies and policy implementation...
February 21, 2024: Nicotine & Tobacco Research
https://read.qxmd.com/read/38378209/levels-of-nicotine-and-tobacco-specific-nitrosamines-in-oral-nicotine-pouches
#17
JOURNAL ARTICLE
Nadja Mallock, Thomas Schulz, Sebastian Malke, Nadine Dreiack, Peter Laux, Andreas Luch
BACKGROUND: Nicotine pouches without tobacco are new products that deliver nicotine into the body via the oral mucosa. There is a lack of independent research on the chemical composition and product characteristics of these products, contributing to uncertainties regarding product regulation. This study sought to address knowledge gaps by assessing levels of nicotine and screening for tobacco-specific nitrosamines (TSNAs) in a sample of these products. METHODS: Nicotine pouches (n=44) and nicotine-free pouches (n=2) from 20 different manufacturers were analysed regarding their contents of nicotine and TSNAs by gas chromatography with flame ionisation and liquid chromatography-tandem mass spectrometry, respectively...
February 20, 2024: Tobacco Control
https://read.qxmd.com/read/38370494/prevalence-knowledge-and-concerns-regarding-the-use-of-heated-tobacco-products-and-electronic-cigarettes-among-young-japanese-physicians
#18
JOURNAL ARTICLE
Yuichiro Otsuka, Yoshitaka Kaneita, Osamu Itani, Suguru Nakajima
INTRODUCTION: Heated tobacco products (HTPs) and e-cigarettes (ECs) have gained traction as alternatives for harm reduction, especially in Japan. In particular, the use of HTPs is rapidly gaining popularity among young adults in Japan, with a prevalence of 10.9% in 2020. Despite uncertainties regarding the health effects of HTPs and ECs, concerns regarding nicotine and carcinogens persist. Although physicians play a vital role in smoking cessation, they lack awareness and concerns regarding HTPs...
2024: Tobacco Induced Diseases
https://read.qxmd.com/read/38368949/in-planta-expression-of-specific-single-chain-fragment-antibody-scfv-against-nucleocapsid-protein-of-fig-mosaic-virus-fmv
#19
JOURNAL ARTICLE
Mahsa Jahandideh, Farshad Rakhshandehroo, Mohammad Reza Safarnejad, Amir Sahraroo, Toufic Elbeaino
Fig mosaic virus (FMV) is recognized as the main viral agent associated with the mosaic disease (MD) of fig trees (Ficus carica). Due to its worldwide occurrence, FMV represents the most significant global threat to the production of fig fruit. A disease management strategy against the MD in fig orchards has never been effective; and therefore, expression of recombinant antibody in plant cells could provide an alternative approach to suppress FMV infections. In this study we focused on expressing a specific recombinant antibody, a single-chain variable fragment (scFv), targeting the nucleocapsid protein (NP) of FMV in planta...
February 16, 2024: Journal of Virological Methods
https://read.qxmd.com/read/38367996/retreatment-of-symptomatic-chronic-bronchitis-with-bronchial-rheoplasty
#20
JOURNAL ARTICLE
Theresa Klemm, William Krimsky, Kelly Welz, Arschang Valipour
A man in his early 70s with a long-standing history of chronic bronchitis presented to our department 3 years ago with debilitating chronic cough and excessive sputum production. He had no previous diagnosis of chronic obstructive pulmonary disease and without evidence of severe respiratory tract infections. Due to his symptom burden and impairments in daily activities, the patient was considered to be an appropriate candidate for bronchial rheoplasty, a novel endoscopic treatment for patients with chronic bronchitis...
February 17, 2024: BMJ Case Reports
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