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a blood clot

Vail Natale Júnior, Francisley Ávila Souza, Eduardo Vedovatto, Renato Sussumu Nishioka, Pier Paolo Poli, Paulo Sérgio Perri de Carvalho
The purpose of this study was to evaluate the preservation of alveolar dimensions in human fresh extraction sockets filled with a composite bovine bone graft by means of design of single-blind randomized clinical trial. Forty participants had monoradicular teeth extracted (one teeth in each participant), and after were randomly divided into 2 groups: individuals whose fresh sockets were filled with the composite heterologous bone graft (Biomaterial Group), or with blood clot (Control Group). After extraction, the fresh sockets were measured at their greatest mesiodistal (MD) and bucco-lingual/palatal (BL/P) distance...
November 2018: Brazilian Dental Journal
Wendy C Ziai, J Ricardo Carhuapoma
PURPOSE OF REVIEW: This article describes the advances in the management of spontaneous intracerebral hemorrhage in adults. RECENT FINDINGS: Therapeutic intervention in intracerebral hemorrhage has continued to focus on arresting hemorrhage expansion, with large randomized controlled trials addressing the effectiveness of rapidly lowering blood pressure, hemostatic therapy with platelet transfusion, and other clotting complexes and clot volume reduction both of intraventricular and parenchymal hematomas using minimally invasive techniques...
December 2018: Continuum: Lifelong Learning in Neurology
Pavel Roudnický, Jiří Vorel, Jana Ilgová, Michal Benovics, Adam Norek, Lucie Jedličková, Libor Mikeš, David Potěšil, Zbyněk Zdráhal, Jan Dvořák, Milan Gelnar, Martin Kašný
BACKGROUND: Serpins are a superfamily of serine peptidase inhibitors that participate in the regulation of many physiological and cell peptidase-mediated processes in all organisms (e.g. in blood clotting, complement activation, fibrinolysis, inflammation, and programmed cell death). It was postulated that in the blood-feeding members of the monogenean family Diplozoidae, serpins could play an important role in the prevention of thrombus formation, activation of complement, inflammation in the host, and/or in the endogenous regulation of protein degradation...
2018: Parasite: Journal de la Société Française de Parasitologie
Anna D Kuprash, Alexey M Shibeko, Ramya Vijay, Sukesh C Nair, Alok Srivastava, Fazoil I Ataullakhanov, Mikhail A Panteleev, Anna N Balandina
Blood coagulation is a delicately regulated space- and time-dependent process that leads to the formation of fibrin clots preventing blood loss upon vascular injury. The sensitivity of the coagulation network was previously investigated without accounting for transport processes. To investigate its sensitivity to coagulation factor deficiencies in a spatial reaction-diffusion system, we combined an in vitro experimental design with a computational systems biology model. Clot formation in platelet-free plasma supplemented with phospholipids was activated with identical amounts of tissue factor (TF) either homogeneously distributed (concentration 5 pM, homogeneous model) or immobilized on the surface (surface density 100 pmole/m2 , spatially heterogeneous model)...
November 14, 2018: Biophysical Journal
Jian Jing, Zhenhuan Du, Songyang Ji, Keqiang Han
The hypercoagulable state occurs in a group of prothrombotic disorders associated with an increased risk for thromboembolic events, but it is difficult to diagnose due to the lack of available biomarkers. This study aimed to investigate systematic changes of urinary proteome in acute hypercoagulable state induced by certain antifibrinolytics. To reduce the effects of both genetic and environmental factors on the urinary proteome, we used a rat model of acute hypercoagulable state induced by an antifibrinolytic agent ε-aminocaproic acid, resembling human hypercoagulable state...
December 1, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Amir Shamshirian, Ali Reza Mohseni, Ali Akbar Pourfathollah, Shirin Mehdipour, Samira Hosseini, Atiyeh Ghorbanpour, Soheil Azizi
BACKGROUND/OBJECTIVES: Blood is a vital resource that its utilization is ever increasing throughout the world and blood wastage is a global challenge that needs to be controlled. Most blood resources are used during complications of pregnancy, trauma, severe childhood anemia, gynecology, cancers, surgery, hematology disorders, and chronic diseases. Units that are expired, broken bags, returning the blood unit after 30 min, blood clotted units, etc., which are due to lack of awareness may result in the wastage of blood products...
December 4, 2018: Acta Clinica Belgica
Deniz Goren Sahin, Betül N Bayraktutar, Ayşe Yıldız Taş, Olga Meltem Akay, Abdullah Ozkaya, Özlem Yalcin, Afsun Sahin
PURPOSE: To evaluate clotting dynamics by a new tool called rotational tromboelastometry (ROTEM) in retinal vein occlusion. MATERIALS AND METHODS: Thirty-six patients who were diagnosed with retinal vein occlusion and 43 age and sex matched healthy controls were included in this study. Diabetes and use of anticoagulant therapy were exclusion criterias. All study participants underwent detailed ophthalmologic and systemic medical examination, including blood pressure measurement, hemoglobin-hematocrit levels, platelet count, coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen levels, and D-dimer levels...
December 4, 2018: Current Eye Research
Shanshan Li, Chenfang Shen, Kuangyi Shu, Jie Liu, Xiaoou Wang, Fanfan Li, Xiao Yang, Zhaohua Zhang, Bi Chen, Minghua Jiang
OBJECTIVE: To carry out phenotypic and genotypic analysis for two Chinese pedigrees affected with coagulation factor XII (F XII) deficiency. METHODS: Plasma prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), and blood coagulation factor VIII, IX, XI, XII activity (FVIII:C, FIX:C, FXI:C, FXII:C) were determined with one stage clotting assay on a STAGO coagulation analyzer. FXII antigen was determined with an enzyme linked immunosorbent assay (ELISA)...
December 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Caroline Shams Hakimi, Sukhi Singh, Camilla Hesse, Anders Jeppsson
BACKGROUND: Excessive bleeding is a significant problem in cardiac surgery. Fibrinogen and platelet concentrate transfusion are used clinically to improve haemostasis and reduce bleeding but little is known about their functional effects on coagulation and platelet function in patients with ongoing bleeding. METHODS: Forty-two patients with ongoing bleeding after cardiac surgery were included in an observational study. Patients received either fibrinogen concentrate (n = 16), platelet concentrate (n = 12), or both fibrinogen and platelets (n = 14), median doses 2 g fibrinogen and 2 units platelets given at one occasion...
December 3, 2018: Acta Anaesthesiologica Scandinavica
Christian Bamberg, Laura Mickley, Anne Henkelmann, Katja Niepraschk-von Dollen, Lutz Kaufner, Christian V Heymann, Wolfgang Henrich, Franziska Pauly
PURPOSE: Postpartum haemorrhage (PPH) is a leading cause of maternal mortality and morbidity. Our aim was to investigate the relationships between antenatal factor XIII (FXIII), fibrinogen levels, and blood loss at childbirth. METHODS: This prospective observational study evaluated an unselected cohort of pregnant women admitted for intended vaginal deliveries of singletons at term. To determine clotting factor levels, we obtained blood samples at a maximum of three days prior to vaginal delivery...
December 3, 2018: Archives of Gynecology and Obstetrics
Anis Haddad, Olfa Zoukar, Houda Mhabrich, Awatef Hajjeji, Raja Faleh
In recent years, the incidence of placenta accreta and associated complications has increased significantly. The authors report the case of a pregnant woman in the 5th month of pregnancy for premature rupture of the membranes. The placenta was inserted low. The evolution was marked spontaneous work followed by the expulsion of the fetus. The delivery of the placenta was haemorrhagic and incomplete. Ultrasonic testing showed a placental fragment integrated in the thickness of the myometrium. Conservative treatment with methotrexate was published a few days later and MRI showed that the anterior uterine sac was filled with blood clots associated with pelvic effusion...
2018: Case Reports in Obstetrics and Gynecology
Alexandra G May, Ryan A Orizondo, Brian J Frankowski, Peter D Wearden, William J Federspiel
Respiratory failure is a significant problem within the pediatric population. A means of respiratory support that readily allows ambulation could improve treatment. The Pittsburgh Pediatric Ambulatory Lung (P-PAL) is being developed as a wearable pediatric pump-lung for long-term respiratory support and has previously demonstrated positive benchtop results. This study aimed to evaluate acute (4-6 hours) in vivo P-PAL performance, as well as develop an optimal implant strategy for future long-term studies. The P-PAL was connected to healthy sheep (n = 6, 23-32 kg) via cannulation of the right atrium and pulmonary artery...
November 21, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Rachel Sara Bercovitz
There is a delicate balance between bleeding and clotting in patients on circuits such as ventricular assist devices or extracorporeal membrane oxygenation. Traditional coagulation tests, prothrombin time, activated partial thromboplastin time, and anti-factor Xa levels, are used to monitor patients on these devices. However, turnaround times and inability to assess global hemostasis, including platelets and fibrinogen have contributed to a recognition that faster, accurate, and more informative coagulation tests are needed...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
Sarah H O'Brien
Heavy menstrual bleeding (HMB) is frequently reported by adolescents. The role of the hematologist is threefold in evaluating such patients: (1) perform a clinical and laboratory evaluation for an underlying bleeding disorder on the basis of the degree of clinical suspicion, (2) identify and manage any concomitant iron deficiency, and (3) provide input to the referring provider regarding the management of HMB, particularly for patients with identified hemostatic defects. Several clues in the menstrual history should raise suspicion for an underlying bleeding disorder, such as menses lasting >7 days, menstrual flow which soaks >5 sanitary products per day or requires product change during the night, passage of large blood clots, or failure to respond to conventional therapies...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
Antonia Barceló, Daniel Morell-Garcia, Pilar Sanchís, José Antonio Peña-Zarza, Josep Miquel Bauça, Javier Piérola, Mónica de la Peña, Nuria Toledo-Pons, Paloma Giménez, Caterina Ribot, Alberto Alonso-Fernández
OBJECTIVE: Increased blood coagulation might be one important mechanism linking obstructive sleep apnea (OSA) with cardiovascular diseases. We tested the association between several hemostatic parameters and sleep breathing-related variables in a representative pediatric population with a clinical suspicion of OSA. METHODS: Polysomnography was performed in 152 snoring children to diagnose OSA. Anthropometric and clinical data were registered and venous blood samples were collected for the measurement of platelet count, plateletcrit, platelet distribution width (PDW), mean platelet volume (MPV), prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen and C-reactive protein...
October 13, 2018: Sleep Medicine
Vikhyat S Bebarta, Normalynn Garrett, Susan Boudreau, Maria Castaneda
Background: Hydroxyethyl starch (Hextend) has been used for hemorrhagic shock resuscitation, however, hydroxyethyl starch may be associated with adverse outcomes. Objective: To compare systolic blood pressure (sBP) in animals that had 30% of their blood volume removed and treated with intravenous hydroxocobalamin, hydroxyethyl starch, or no fluid. Methods: Twenty-eight swine (45-55 kg) were anesthetized and instrumented with continuous femoral and pulmonary artery pressure monitoring...
November 5, 2018: Military Medicine
Eduardo Anitua, Paquita Nurden, Roberto Prado, Alan T Nurden, Sabino Padilla
The healing of vascularized mammalian tissue injuries initiate with hemostasis and clotting as part of biological defense system leading to the formation of a fibrin clot in which activated platelets are trapped to quickly stop bleeding and destroy microbials. In order to harness the therapeutic potential of biomolecules secreted by platelets and stemmed from plasma, blood deconstruction has allowed to yield autologous platelet-and plasma-derived protein fibrin scaffold. The autologous growth factors and microparticles stemmed from platelets and plasma, interact with fibrin, extracellular matrix, and tissue cells in a combinatorial, synergistic, and multidirectional way on mechanisms governing tissue repair...
November 21, 2018: Biomaterials
O S Brusov, I V Oleichik, M I Faktor, N S Karpova, S V Sizov, O A Yunilaynen
AIM: To detect coagulability impairment of blood plasma in patients with schizophrenia or affective disease in a state of exacerbation using a thrombodynamics test. MATERIAL AND METHODS: The study included 46 women, 32 with attack-like/shift-like/or continuous schizophrenia (ICD-10: F20.00, F20.01, F20.02), 7 with schizotypal disorder (ICD-10: F21.3-21.4) and 7 with affective disorder (ICD-10: F32.00, F32.3). Thrombodynamics tests were performed on T-2 thrombodynamics analyzer ('Hemacore LLC', Moscow, Russia)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Chandrabose Selvaraj, Ramanathan Bharathi Priya, Sanjeev Kumar Singh
Gram-positive bacteria signify a surface organelle that decorates the cell surfaces using Sortase enzymes. The mechanism of SrtC lings to the formation of amide or peptide bonds between cell surface proteins that sorting signal to strategically positioned amino groups. Sorting signals linked to peptidoglycan function as the principal architects of cell wall and facilitate each microbe to effectively interact with its host environment. These enzymes play a fundamental role in microbial physiology and interestingly, sequence analysis on Gram-positive bacteria implies that approximately 60% of sortases are categorized into six families, and from that SrtA and SrtC are widely investigated in various literatures...
November 30, 2018: Current Topics in Medicinal Chemistry
Carolyn L Hodo, Jessica Y Rodriguez, Rachel Curtis-Robles, Italo B Zecca, Karen F Snowden, Kevin J Cummings, Sarah A Hamer
BACKGROUND: Vector-borne diseases have an adverse impact on health of dogs, and infected dogs can be sentinels for human infection. Infection with Trypanosoma cruzi, an agent of Chagas disease, causes fatal heart disease in dogs across the southern United States but has been neglected from wide-scale prevalence studies. OBJECTIVES: To determine the prevalence of exposure to T. cruzi, Ehrlichia spp., Anaplasma spp., Borrelia burgdorferi, and infection with Dirofilaria immitis among dogs in shelters across Texas and to identify risk factors for T...
November 29, 2018: Journal of Veterinary Internal Medicine
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