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https://www.readbyqxmd.com/read/29046902/holistic-mapping-of-striatum-surfaces-in-the-laplace-beltrami-embedding-space
#1
Jin Kyu Gahm, Yonggang Shi
In brain shape analysis, the striatum is typically divided into three parts: the caudate, putamen, and accumbens nuclei for its analysis. Recent connectivity and animal studies, however, indicate striatum-cortical inter-connections do not always follow such subdivisions. For the holistic mapping of striatum surfaces, conventional spherical registration techniques are not suitable due to the large metric distortions in spherical parameterization of striatal surfaces. To overcome this difficulty, we develop a novel striatal surface mapping method using the recently proposed Riemannian metric optimization techniques in the Laplace-Beltrami (LB) embedding space...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/29045421/enlarged-virchow-robin-spaces-associate-with-cognitive-decline-in-multiple-sclerosis
#2
Alice Favaretto, Andrea Lazzarotto, Alice Riccardi, Stefano Pravato, Monica Margoni, Francesco Causin, Maria Giulia Anglani, Dario Seppi, Davide Poggiali, Paolo Gallo
The clinical significance of Virchow Robin spaces (VRS) in inflammatory brain disorders, especially in multiple sclerosis (MS), is still undefined. We analysed enlarged VRS (eVRS) by means of phase sensitive inversion recovery (PSIR) MRI sequence and investigated their association with inflammation or brain atrophy, and to clinical or physical disability. Forty-three MS patients (21 clinically isolated syndrome suggestive of MS [CIS], 15 RRMS, 7 progressive [PMS]) and 10 healthy controls (HC) were studied. 3DT1, 3DFLAIR and 2DPSIR images were obtained with a 3T MRI scanner...
2017: PloS One
https://www.readbyqxmd.com/read/29039254/the-antidepressant-efficacy-of-subanesthetic-dose-ketamine-does-not-correlate-with-baseline-subcortical-volumes-in-a-replication-sample-with-major-depressive-disorder
#3
Mark J Niciu, Nicolas D Iadarola, Dipavo Banerjee, David A Luckenbaugh, Minkyung Park, Marc Lener, Lawrence Park, Dawn F Ionescu, Elizabeth D Ballard, Nancy E Brutsche, Nirmala Akula, Francis J McMahon, Rodrigo Machado-Vieira, Allison C Nugent, Carlos A Zarate
BACKGROUND: This study sought to reproduce, in a larger sample, previous findings of a correlation between smaller raw 3-Tesla (3T) hippocampal volumes and improved antidepressant efficacy of ketamine in individuals with major depressive disorder (MDD). A secondary analysis stratified subjects according to functional BDNF rs6265 (val66met) genotype. METHODS: Unmedicated subjects with treatment-resistant MDD ( n=55) underwent baseline structural 3T MRI. Data processing was conducted with FSL/FIRST and Freesurfer software...
October 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29038922/lower-fractional-anisotropy-in-the-gray-matter-of-amygdala-hippocampus-nucleus-accumbens-circuit-in-methamphetamine-users-an-in-vivo-diffusion-tensor-imaging-study
#4
Yadi Li, Wenhua Zhou, Haibo Dong, Wenwen Shen, Jianbing Zhang, Feng Li, Lingjun Zhang
The basolateral amygdala (BLA), hippocampal ventral subiculum, and nucleus accumbens (NAc) comprise the amygdala-hippocampus-NAc (AHN) circuit, which is implicated in drug seeking and reward. The goal of this study was to evaluate microstructural changes and relevant clinical features of the AHN circuit gray matter (GM) in methamphetamine (MA) users using diffusion tensor imaging (DTI). Thirty MA users and 30 age-matched normal volunteers underwent 3-T MR imaging to obtain structural T1-weighted images and DTI data...
October 16, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29029762/thinner-cortex-in-patients-with-subjective-cognitive-decline-is-associated-with-steeper-decline-of-memory
#5
Sander C J Verfaillie, Rosalinde E Slot, Betty M Tijms, Femke Bouwman, Marije R Benedictus, Jozefien M Overbeek, Teddy Koene, Hugo Vrenken, Philip Scheltens, Frederik Barkhof, Wiesje M van der Flier
We aimed to investigate associations between regional cortical thickness and rate of decline over time in 4 cognitive domains in patients with subjective cognitive decline (SCD). We included 233 SCD patients with the total number of 654 neuropsychological assessments (median = 3, range = 2-8) and available baseline magnetic resonance imaging from the Amsterdam Dementia Cohort (125 males, age: 63 ± 9, Mini-Mental State Examination score: 28 ± 2). We assessed longitudinal cognitive functioning at baseline and follow-up in 4 cognitive domains (composite Z-scores): memory, attention, executive function, and language...
September 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28990457/age-at-first-exposure-to-repetitive-head-impacts-is-associated-with-smaller-thalamic-volumes-in-former-professional-american-football-players
#6
Vivian Schultz, Robert A Stern, Yorghos Tripodis, Julie M Stamm, Pawel Wrobel, Christian Lepage, Isabelle Weir, Jeffrey P Guenette, Alicia Chua, Michael L Alosco, Christine M Baugh, Nathan G Fritts, Brett Martin, Christine Chaisson, Michael J Coleman, Alexander P Lin, Ofer Pasternak, Martha E Shenton, Inga Katharina Koerte
Thalamic atrophy has been associated with exposure to repetitive head impacts (RHI) in professional fighters. The aim of this study is to investigate whether or not age at first exposure (AFE) to RHI is associated with thalamic volume in symptomatic former National Football League (NFL) players at risk for chronic traumatic encephalopathy (CTE). Eighty-six symptomatic former NFL players (mean age=54.9±7.9 years) were included. T1-weighted data were acquired on a 3T MRI and thalamic volumes were derived using FreeSurfer...
October 7, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28987907/left-caudal-middle-frontal-gray-matter-volume-mediates-the-effect-of-age-on-self-initiated-elaborative-encoding-strategies
#7
Robyn A Husa, Brian A Gordon, Madison M Cochran, Madison Bertolin, Danielle N Bond, Brenda A Kirchhoff
Aging is associated with decreased self-initiated use of effective elaborative encoding strategies. Little is currently known regarding what factors drive age differences in self-initiated encoding strategies. The present research investigated whether age differences in prefrontal gray matter integrity contribute to age differences in self-initiated elaborative encoding strategies. The relationships between age, prefrontal regional gray matter volumes, and overall use of self-initiated elaborative encoding strategies were examined in healthy younger and older adults...
October 4, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28984590/disinhibition-in-alzheimer-s-disease-is%C3%A2-associated-with-reduced-right-frontal-pole-cortical-thickness
#8
Elizabeth Finger, Jing Zhang, Bradford Dickerson, Yves Bureau, Mario Masellis
Neuropsychiatric symptoms in Alzheimer's disease are among the most disabling and difficult aspects for caregivers and treating health professionals to manage. Despite the high prevalence of these behaviors, little is known about the factors which lead some patients to develop florid behavioral symptoms while others may progress to severe dementia without such phenomenon. We examined whether regional brain volumes as measured by cortical thickness would predict the presence or absence of disinhibition in patients with Alzheimer's disease...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28979205/atrophy-of-the-posterior-subiculum-is-associated-with-memory-impairment-tau-and-a%C3%AE-pathology-in-non-demented-individuals
#9
Olof Lindberg, Gustav Mårtensson, Erik Stomrud, Sebastian Palmqvist, Lars-Olof Wahlund, Eric Westman, Oskar Hansson
Alzheimer's disease (AD) is associated with atrophy of the cornu ammonis (CA) 1 and the subiculum subfield of the hippocampus (HC), and with deficits in episodic memory and spatial orientation. These deficits are mainly associated with the functionality of the posterior HC. We therefore hypothesized that key AD pathologies, i.e., β-amyloid and tau pathology would be particularly associated with the volume of the posterior subiculum in non-demented individuals. In our study we included 302 cognitively normal elderly participants (CN), 183 patients with subjective cognitive decline (SCD) and 171 patients with amnestic mild cognitive impairment (MCI), all of whom underwent 3T magnetic resonance images (MRI)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28978362/reliability-and-utility-of-manual-and-automated-estimates-of-total-intracranial-volume
#10
Samuel J Crowley, Jared J Tanner, Daniel Ramon, Nadine A Schwab, Loren P Hizel, Catherine C Price
OBJECTIVES: Total intracranial volume (TICV) is an important control variable in brain-behavior research, yet its calculation has challenges. Manual TICV (Manual) is labor intensive, and automatic methods vary in reliability. To identify an accurate automatic approach we assessed the reliability of two FreeSurfer TICV metrics (eTIV and Brainmask) relative to manual TICV. We then assessed how these metrics alter associations between left entorhinal cortex (ERC) volume and story retention...
October 5, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28976002/structural-co-variance-patterns-in-migraine-a-cross-sectional-study-exploring-the-role-of-the-hippocampus
#11
Catherine D Chong, Gina M Dumkrieger, Todd J Schwedt
OBJECTIVE: To interrogate hippocampal morphology and structural co-variance patterns in migraine patients and to investigate whether structural co-variance patterns relate to migraine disease characteristics. BACKGROUND: Migraine is associated with structural alterations in widespread cortical and subcortical regions associated with the sensory, cognitive, and affective components of pain processing. Recent studies have shown that migraine patients have differences in hippocampal structure and function relative to healthy control subjects, but whether hippocampal structure relates to disease characteristics including frequency of attacks, years lived with migraine and symptoms of allodynia remains unknown...
October 4, 2017: Headache
https://www.readbyqxmd.com/read/28970143/advantages-of-cortical-surface-reconstruction-using-submillimeter-7%C3%A2-t-memprage
#12
Natalia Zaretskaya, Bruce Fischl, Martin Reuter, Ville Renvall, Jonathan R Polimeni
Recent advances in MR technology have enabled increased spatial resolution for routine functional and anatomical imaging, which has created demand for software tools that are able to process these data. The availability of high-resolution data also raises the question of whether higher resolution leads to substantial gains in accuracy of quantitative morphometric neuroimaging procedures, in particular the cortical surface reconstruction and cortical thickness estimation. In this study we adapted the FreeSurfer cortical surface reconstruction pipeline to process structural data at native submillimeter resolution...
September 29, 2017: NeuroImage
https://www.readbyqxmd.com/read/28959379/empowering-cortical-thickness-measures-in-clinical-diagnosis-of-alzheimer-s-disease-with-spherical-sparse-coding
#13
Jie Zhang, Yonghui Fan, Qingyang Li, Paul M Thompson, Jieping Ye, Yalin Wang
Cortical thickness estimation performed in vivo via magnetic resonance imaging (MRI) is an important technique for the diagnosis and understanding of the progression of Alzheimer's disease (AD). Directly using raw cortical thickness measures as features with Support Vector Machine (SVM) for clinical group classification only yields modest results since brain areas are not equally atrophied during AD progression. Therefore, feature reduction is generally required to retain only the most relevant features for the final classification...
April 2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/28955255/inattention-predicts-increased-thickness-of-left-occipital-cortex-in-men-with-attention-deficit-hyperactivity-disorder
#14
Peter Sörös, Katharina Bachmann, Alexandra P Lam, Manuela Kanat, Eliza Hoxhaj, Swantje Matthies, Bernd Feige, Helge H O Müller, Christiane Thiel, Alexandra Philipsen
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) in adulthood is a serious and frequent psychiatric disorder with the core symptoms inattention, impulsivity, and hyperactivity. The principal aim of this study was to investigate associations between brain morphology, i.e., cortical thickness and volumes of subcortical gray matter, and individual symptom severity in adult ADHD. METHODS: Surface-based brain morphometry was performed in 35 women and 29 men with ADHD using FreeSurfer...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28945119/reduced-structural-connectivity-in-frontostriatal-white-matter-tracts-in-the-associative-loop-in-schizophrenia
#15
James J Levitt, Paul G Nestor, Laura Levin, Paula Pelavin, Pan Lin, Marek Kubicki, Robert W McCarley, Martha E Shenton, Yogesh Rathi
OBJECTIVE: The striatum receives segregated and integrative white matter tracts from the cortex facilitating information processing in the cortico-basal ganglia network. The authors examined both types of input tracts in the striatal associative loop in chronic schizophrenia patients and healthy control subjects. METHOD: Structural and diffusion MRI scans were acquired on a 3-T system from 26 chronic schizophrenia patients and 26 matched healthy control subjects...
September 15, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28940848/executive-function-and-functional-and-structural-brain-differences-in-middle-age-adults-with-autism-spectrum-disorder
#16
B Blair Braden, Christopher J Smith, Amiee Thompson, Tyler K Glaspy, Emily Wood, Divya Vatsa, Angela E Abbott, Samuel C McGee, Leslie C Baxter
There is a rapidly growing group of aging adults with autism spectrum disorder (ASD) who may have unique needs, yet cognitive and brain function in older adults with ASD is understudied. We combined functional and structural neuroimaging and neuropsychological tests to examine differences between middle-aged men with ASD and matched neurotypical (NT) men. Participants (ASD, n = 16; NT, n = 17) aged 40-64 years were well-matched according to age, IQ (range: 83-131), and education (range: 9-20 years)...
September 21, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28928491/freezing-of-gait-is-associated-with-cortical-thinning-in-mesial-frontal-cortex
#17
Miroslav Vastik, Pavel Hok, Jan Valosek, Petr Hlustik, Katerina Mensikova, Petr Kanovsky
AIMS: The relationship between freezing of gait (FOG) and regional brain atrophy has been intensively investigated, but it is still not clearly understood. The study objective was to test whether grey matter (GM) atrophy contributes to FOG in Parkinson´s disease (PD) using a surface-based algorithm. METHODS: We investigated 21 patients with PD, 11 with FOG and 10 without FOG. Both groups were assessed using a FOG questionnaire and Hoehn and Yahr staging. High resolution T1-weighted brain images were acquired for each subject using a 1...
September 13, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28923718/automated-measurement-of-hippocampal-subfields-in-ptsd-evidence-for-smaller-dentate-gyrus-volume
#18
Jasmeet P Hayes, Scott Hayes, Danielle R Miller, Ginette Lafleche, Mark W Logue, Mieke Verfaellie
Smaller hippocampal volume has been consistently observed as a biomarker of posttraumatic stress disorder (PTSD). However, less is known about individual volumes of the subfields composing the hippocampus such as the dentate gyrus and cornu ammonis (CA) fields 1-4 in PTSD. The aim of the present study was to examine the hypothesis that volume of the dentate gyrus, a region putatively involved in distinctive encoding of similar events, is smaller in individuals with PTSD versus trauma-exposed controls. Ninety-seven recent war veterans underwent structural imaging on a 3T scanner and were assessed for PTSD using the Clinician-Administered PTSD Scale...
September 9, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28921167/brain-structural-concomitants-of-resting-state-heart-rate-variability-in-the-young-and-old-evidence-from-two-independent-samples
#19
Hyun Joo Yoo, Julian F Thayer, Steven Greening, Tae-Ho Lee, Allison Ponzio, Jungwon Min, Michiko Sakaki, Lin Nga, Mara Mather, Julian Koenig
Previous research has shown associations between brain structure and resting state high-frequency heart rate variability (HF HRV). Age affects both brain structure and HF HRV. Therefore, we sought to examine the relationship between brain structure and HF HRV as a function of age. Data from two independent studies were used for the present analysis. Study 1 included 19 older adults (10 males, age range 62-78 years) and 19 younger adults (12 males, age range 19-37). Study 2 included 23 older adults (12 males; age range 55-75) and 27 younger adults (17 males; age range 18-34)...
September 18, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28919059/rates-of-hippocampal-atrophy-and-presence-of-post-mortem-tdp-43-in-patients-with-alzheimer-s-disease-a-longitudinal-retrospective-study
#20
Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwell
BACKGROUND: Post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with Alzheimer's disease. TAR DNA binding protein 43 (TDP-43) is another protein linked to Alzheimer's disease. We aimed to investigate whether hippocampal TDP-43 is associated with increased rates of hippocampal atrophy. METHODS: In this longitudinal retrospective study, we analysed post-mortem brain tissue of all individuals with an Alzheimer's disease spectrum pathological diagnosis who had antemortem head MRI scans between Jan 1, 1999, and Dec 31, 2012, and who had been recruited into the Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic Alzheimer's Disease Patient Registry, or the Mayo Clinic Study of Aging...
November 2017: Lancet Neurology
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