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Yuankai Huo, Shunxing Bao, Prasanna Parvathaneni, Bennett A Landman
Whole brain segmentation and cortical surface parcellation are essential in understanding the brain anatomical-functional relationship. Multi-atlas segmentation has been regarded as one of the leading segmentation methods for the whole brain segmentation. In our recent work, the multi-atlas technique has been adapted to surface reconstruction using a method called Multi-atlas CRUISE (MaCRUISE). The MaCRUISE method not only performed the consistent volume-surface analyses but also shown advantages on robustness compared with FreeSurfer method...
March 2018: Proceedings of SPIE
Julien Lefèvre, Antonietta Pepe, Jennifer Muscato, Francois De Guio, Nadine Girard, Guillaume Auzias, David Germanaud
Understanding the link between structure, function and development in the brain is a key topic in neuroimaging that benefits from the tremendous progress of multi-modal MRI and its computational analysis. It implies, inter alia , to be able to parcellate the brain volume or cortical surface into biologically relevant regions. These parcellations may be inferred from existing atlases (e.g., Desikan) or sets of rules, as would do a neuroanatomist for lobes, but also directly driven from the data (e.g., functional or structural connectivity) with minimum a priori...
2018: Frontiers in Neuroscience
Cristian Donos, Joshua Breier, Elliott Friedman, Patrick Rollo, Jessica Johnson, Lauren Moss, Stephen Thompson, Melissa Thomas, Omotola Hope, Jeremy Slater, Nitin Tandon
OBJECTIVES: Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique for focal epilepsy. A major appeal of LITT is that it may result in fewer cognitive deficits, especially when targeting dominant hemisphere mesial temporal lobe (MTL) epilepsy. To evaluate this, as well as to determine seizure outcomes following LITT, we evaluated the relationships between ablation volumes and surgical or cognitive outcomes in 43 consecutive patients undergoing LITT for MTL epilepsy...
June 12, 2018: Epilepsia
Per M Aslaksen, Martin K Bystad, Marte C Ørbo, Torgil R Vangberg
Total hippocampal volume has previously been shown to correlate with performance on tests for verbal episodic memory. However, there are sparse evidence on how hippocampal subfield volumes are related to verbal episodic memory in healthy adults. The present study investigated the association between volumes of separate hippocampal subfields and verbal episodic memory performance in healthy volunteers. Forty-seven participants (31 females) between 20 to 71 years age underwent testing with the California Verbal Learning Test II (CVLT II), and the Wechsler Abbreviated Scale of Intelligence (WASI) to obtain an estimate of cognitive functioning...
June 8, 2018: Behavioural Brain Research
Ziliang Wang, Lingdan Wu, Kai Yuan, Yanbo Hu, Hui Zheng, Xiaoxia Du, Guangheng Dong
Although online gaming may lead to Internet gaming disorder (IGD), most players are recreational game users (RGUs) who do not develop IGD. Thus far, little is known about brain structural abnormalities in IGD subjects relative to RGUs. The inclusion of RGUs as a control group could minimize the potential effects of gaming experience and gaming-related cue familiarity on the neural mechanism of IGD subjects. In the current study, structural magnetic resonance imaging data were acquired from 38 IGD subjects and 66 RGUs with comparable age, gender, and educational level...
June 8, 2018: European Journal of Neuroscience
David E Ross, Alfred L Ochs, David F Tate, Umit Tokac, John Seabaugh, Tracy J Abildskov, Erin D Bigler
NeuroQuant® (NQ) and FreeSurfer (FS) are commonly used computer-automated programs for measuring MRI brain volume. Previously they were reported to have high intermethod reliabilities but often large intermethod effect size differences. We hypothesized that linear transformations could be used to reduce the large effect sizes. This study was an extension of our previously reported study. We performed NQ and FS brain volume measurements on 60 subjects (including normal controls, patients with traumatic brain injury, and patients with Alzheimer's disease)...
May 30, 2018: Psychiatry research. Neuroimaging
Jeffrey P Guenette, Robert A Stern, Yorghos Tripodis, Alicia S Chua, Vivian Schultz, Valerie J Sydnor, Nathaniel Somes, Sarina Karmacharya, Christian Lepage, Pawel Wrobel, Michael L Alosco, Brett M Martin, Christine E Chaisson, Michael J Coleman, Alexander P Lin, Ofer Pasternak, Nikos Makris, Martha E Shenton, Inga K Koerte
Objectives: To determine whether or not automated FreeSurfer segmentation of brain regions considered important in repetitive head trauma can be analyzed accurately without manual correction. Materials and methods: 3 T MR neuroimaging was performed with automated FreeSurfer segmentation and manual correction of 11 brain regions in former National Football League (NFL) players with neurobehavioral symptoms and in control subjects. Automated segmentation and manually-corrected volumes were compared using an intraclass correlation coefficient (ICC)...
2018: NeuroImage: Clinical
Judith Machts, Arturo Cardenas-Blanco, Julio Acosta-Cabronero, Joern Kaufmann, Kristian Loewe, Elisabeth Kasper, Christina Schuster, Johannes Prudlo, Stefan Vielhaber, Peter J Nestor
Objective: To examine whether the distribution of prefrontal cortical thickness in patients with motor neuron disease is normal or bimodal and how it compares to the normal population. Methods: 158 patients with motor neuron disease (MND) and 86 healthy controls (HC) were enrolled in a prospective, two-center study with a common structural MRI protocol. Cortical thickness measures were extracted for the prefrontal cortex, premotor cortex, motor cortex, and occipital cortex using FreeSurfer, adjusted for age and sex, and tested for normality of distribution...
2018: NeuroImage: Clinical
Xuetong Wang, Yang Yu, Weina Zhao, Qiongling Li, Xinwei Li, Shuyu Li, Changhao Yin, Ying Han
The hippocampus plays important roles in memory processing. However, the hippocampus is not a homogeneous structure, which consists of several subfields. The hippocampal subfields are differently affected by many neurodegenerative diseases, especially mild cognitive impairment (MCI). Amnestic mild cognitive impairment (aMCI) and subcortical vascular mild cognitive impairment (svMCI) are the two subtypes of MCI. aMCI is characterized by episodic memory loss, and svMCI is characterized by extensive white matter hyperintensities and multiple lacunar infarctions on magnetic resonance imaging...
2018: Frontiers in Neurology
Marco Sarà, Riccardo Cornia, Massimiliano Conson, Antonio Carolei, Simona Sacco, Francesca Pistoia
Previous evidence suggests that hallucinations and delusions may be detected in patients with the most severe forms of motor disability including locked-in syndrome (LIS). However, such phenomena are rarely described in LIS and their presence may be underestimated as a result of the severe communication impairment experienced by the patients. In this study, we retrospectively reviewed the clinical history and the neuroimaging data of a cohort of patients with LIS in order to recognize the presence of hallucinations and delusions and to correlate it with the pontine damage and the presence of any cortical volumetric changes...
2018: Frontiers in Neurology
Andreas Kattem Husøy, Carl Pintzka, Live Eikenes, Asta K Håberg, Knut Hagen, Mattias Linde, Lars Jacob Stovner
Background The relationship between subcortical nuclei and headache is unclear. Most previous studies were conducted in small clinical migraine samples. In the present population-based MRI study, we hypothesized that headache sufferers exhibit reduced volume and deformation of the nucleus accumbens compared to non-sufferers. In addition, volume and deformation of the amygdala, caudate, hippocampus, pallidum, putamen and thalamus were examined. Methods In all, 1006 participants (50-66 years) from the third Nord-Trøndelag Health Survey, were randomly selected to undergo a brain MRI at 1...
January 1, 2018: Cephalalgia: An International Journal of Headache
Avner Thaler, Efrat Kliper, Inbal Maidan, Talia Herman, Keren Rosenberg-Katz, Noa Bregman, Tanya Gurevich, Tamara Shiner, Jeffrey M Hausdorff, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman
Cerebral atrophy has been detected in patients with Parkinson's disease (PD) both with and without dementia, however differentiation based on genetic status has thus far not yielded robust findings. We assessed cortical thickness and subcortical volumes in a cohort of PD patients and healthy controls carriers of the G2019S mutation in the LRRK2 gene and the common GBA mutations, in an attempt to determine whether genetic status influences structural indexes. Cortical thickness and subcortical volumes were computed and compared between six groups of participants; idiopathic PD, GBA-PD, LRRK2-PD, non-manifesting non-carriers (NMNC), GBA-non-manifesting carriers (NMC) and LRRK2-NMC utilizing the FreeSurfer software program...
May 30, 2018: Brain Topography
Landrew S Sevel, Jeff Boissoneault, Janelle E Letzen, Michael E Robinson, Roland Staud
Chronic fatigue syndrome (CFS) is a disorder associated with fatigue, pain, and structural/functional abnormalities seen during magnetic resonance brain imaging (MRI). Therefore, we evaluated the performance of structural MRI (sMRI) abnormalities in the classification of CFS patients versus healthy controls and compared it to machine learning (ML) classification based upon self-report (SR). Participants included 18 CFS patients and 15 healthy controls (HC). All subjects underwent T1-weighted sMRI and provided visual analogue-scale ratings of fatigue, pain intensity, anxiety, depression, anger, and sleep quality...
May 30, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Christoph Abé, Qazi Rahman, Niklas Långström, Eleonore Rydén, Martin Ingvar, Mikael Landén
BACKGROUND: Nonheterosexual individuals have higher risk of psychiatric morbidity. Together with growing evidence for sexual orientation-related brain differences, this raises the concern that sexual orientation may be an important factor to control for in neuroimaging studies of neuropsychiatric disorders. METHODS: We studied sexual orientation in adult psychiatric patients with bipolar disorder (BD) or ADHD in a large clinical cohort (N = 154). We compared cortical brain structure in exclusively heterosexual women (HEW, n = 29) with that of nonexclusively heterosexual women (nHEW, n = 37) using surface-based reconstruction techniques provided by FreeSurfer...
May 29, 2018: Brain and Behavior
Karteek Popuri, Emma Dowds, Mirza Faisal Beg, Rakesh Balachandar, Mahadev Bhalla, Claudia Jacova, Adrienne Buller, Penny Slack, Pheth Sengdy, Rosa Rademakers, Dana Wittenberg, Howard H Feldman, Ian R Mackenzie, Ging-Yuek R Hsiung
Frontotemporal dementia (FTD) is a neurodegenerative disease with a strong genetic basis. Understanding the structural brain changes during pre-symptomatic stages may allow for earlier diagnosis of patients suffering from FTD; therefore, we investigated asymptomatic members of FTD families with mutations in C9orf72 and granulin ( GRN ) genes. Clinically asymptomatic subjects from families with C9orf72 mutation (15 mutation carriers, C9orf72 +; and 23 non-carriers, C9orf72 -) and GRN mutations (9 mutation carriers, GRN +; and 15 non-carriers, GRN -) underwent structural neuroimaging (MRI)...
2018: NeuroImage: Clinical
Vanise C G Amaral, Gustavo Tukamoto, Tadeu Kubo, Ronir Raggio Luiz, Emerson Gasparetto, Maurice B Vincent
Objective The main goal of this study was to correlate migraine improvement, after prophylactic therapy, with cortical thickness changes. Methods Cortical thickness maps were obtained with magnetic resonance imaging (MRI) from 19 patients with migraine before (first scan) and after (second scan) prophylactic treatment, and these were compared with controls using the FreeSurfer MRI tool. Cortical changes were correlated with the headache index (HI). Results Anincrease incortical thickness was found in the right cuneus and precuneus, somatosensory and superior parietal cortices in both patient scans, compared with the controls...
March 2018: Arquivos de Neuro-psiquiatria
Emily C Grossner, Rachel A Bernier, Einat K Brenner, Kathy S Chiou, Frank G Hillary
OBJECTIVE: To examine metacognitive ability (MC) following moderate to severe traumatic brain injury (TBI) using an empirical assessment approach and to determine the relationship between alterations in gray matter volume (GMV) and MC. METHOD: A sample of 62 individuals (TBI n = 34; healthy control [HC] n = 28) were included in the study. Neuroimaging and neuropsychological data were collected for all participants during the same visit. MC was quantified using an approach borrowed from signal detection theory (Type II area under the receiver operating characteristic curve calculation) to evaluate judgments during a modified version of the 3rd edition of the Wechsler Adult Intelligence Scale's Matrix Reasoning subtest where half of the items were presented randomly and half were presented in the order of increasing difficulty...
May 2018: Neuropsychology
A M Granados Sánchez, J F Orejuela Zapata
OBJECTIVE: The pathological classification of hippocampal sclerosis is based on the loss of neurons in the substructures of the hippocampus. This study aimed to evaluate these substructures in patients with hippocampal sclerosis by magnetic resonance imaging and to compare the usefulness of this morphological analysis compared to that of volumetric analysis of the entire hippocampus. MATERIAL AND METHODS: We included 25 controls and 25 patients with hippocampal sclerosis whose diagnosis was extracted from the institutional epilepsy board...
May 25, 2018: Radiología
Alon Kalron, Gilles Allali, Anat Achiron
BACKGROUND AND PURPOSE: Investigate the association between step time variability and related brain structures in accordance with fall status in people with multiple sclerosis (PwMS). METHODS: The study included 225 PwMS. A whole-brain MRI was performed by a high-resolution 3.0-Telsa MR scanner in addition to volumetric analysis based on 3D T1-weighted images using the FreeSurfer image analysis suite. Step time variability was measured by an electronic walkway. Participants were defined as "fallers" (at least two falls during the previous year) and "non-fallers"...
May 28, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Maria T D Gama, Camila C Piccinin, Thiago J R Rezende, Patrick A Dion, Guy A Rouleau, Marcondes C França Junior, Orlando G P Barsottini, José Luiz Pedroso
BACKGROUND: The gene SYNE1 is highly expressed in the cerebellum and its dysfunction is related to an autosomal recessive ataxia (SYNE1-ataxia). The disease was firstly considered a pure cerebellar ataxia however, recent studies have described a broader clinical presentation, including motor neuron disease symptoms. OBJECTIVES: To investigate cerebellar and potential extra-cerebellar changes in SYNE1-ataxia using multimodal neuroimaging analyses. METHODS: Six patients completed clinical and imaging exams, and were compared to age-gender-matched healthy controls...
July 15, 2018: Journal of the Neurological Sciences
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