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Yan-Yan Bian, Long-Chao Wang, Wen-Wei Qian, Jin Lin, Jin Jin, Hui-Ming Peng, Xi-Sheng Weng
OBJECTIVE: Total knee arthroplasty (TKA) is an established surgical technique and is the standard treatment for degenerative knee joint diseases. However, severe pain after TKA makes it difficult for many patients to perform early postoperative rehabilitation and functional exercise, which might result in subsequent unsatisfactory recovery of knee joint function and great reduction in patients' satisfaction and quality of life. Orthopaedic surgeons have tried a large variety of analgesics and analgesic modes to relieve patients' pain after TKA...
November 2018: Orthopaedic Surgery
Yufeng Liu, Xuan Song, Dan Sun, Jiabei Wang, Yaliang Lan, Guangchao Yang, Fanzheng Meng, Yan Wang, Yifeng Cui, Bo Zhang, Xianying Li, Lianxin Liu
BACKGROUND As laparoscopic liver resection is becoming a commonly used method for hepatic surgery, postoperative pain management is emerging as one of the trickiest problems after surgery. The ideal method of pain management is controversial and the optimal strategy for postoperative pain management after surgery remains unclear. The present study evaluated the postoperative analgesic efficacy of parecoxib and fentanyl, and the benefit of a new intravenous parecoxib infusion pump with patient-controlled analgesia after laparoscopic liver resection...
November 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jiansong Fang, Chuipu Cai, Yanting Chai, Jingwei Zhou, Yujie Huang, Li Gao, Qi Wang, Feixiong Cheng
Despite recent advance of therapeutic development, coronary artery disease (CAD) remains one of the major issues to public health. The use of genomics and systems biology approaches to inform drug discovery and development have offered the possibilities for new target identification and in silico drug repurposing. In this study, we propose a network-based, systems pharmacology framework for target identification and drug repurposing in pharmacologic treatment and chemoprevention of CAD. Specifically, we build in silico models by integrating known drug-target interactions, CAD genes derived from the genetic and genomic studies, and the human protein-protein interactome...
January 1, 2019: European Journal of Medicinal Chemistry
Xingye Du, Jiaye Gu
BACKGROUND: The goal of the current meta-analysis is to make a credible and overall assessment about the efficacy and safety of parenteral parecoxib for pain control in total knee arthroplasty (TKA). METHODS: The following online electronic databases, such as PubMed, Cochrane, Embase, were searched to identify the qualified studies updated to August 2018 according to the index words. Weight mean difference (WMD) or risk difference (RD) along with 95% confidence interval (CI) was utilized to analyze the main outcomes...
November 2018: International Journal of Surgery
Hui-Ming Peng, Long-Chao Wang, Wei Wang, Qi-Heng Tang, Wen-Wei Qian, Jin Lin, Jin Jin, Bin Feng, Xing-Hua Yin, Xi-Sheng Weng, Yi-Xin Zhou
BACKGROUND: Total hip arthroplasty (THA) is a well-accepted surgical treatment for terminal hip diseases. OBJECTIVE: To evaluate the effect of preemptive analgesia with parecoxib in patients undergoing primary unilateral THA. STUDY DESIGN: A randomized, double-blind, placebo-controlled study. SETTING: This study was conducted at Peking Union Medical College Hospital and Beijing Jishuitan Hospital in Beijing, China. METHODS: A total of 94 patients scheduled for primary unilateral THA in 2 centers (Peking Union Medical College Hospital and Beijing Jishuitan Hospital) were randomly assigned to receive 40 mg parecoxib (n = 48) or 0...
September 2018: Pain Physician
Rayakorn Moonla, Adisorn Threetipayarak, Chininthon Panpaisarn, Nida Pattayaruk, Unchana Kaewkam, Nipawan Jumpalee, Jatupong Panwilai
STUDY DESIGN: Prospective randomized, double-blind controlled trial. PURPOSE: Here, we aim to compare the efficacy and safety of pain control between pre- and postoperative parecoxib administration in patients who have undergone major spine surgery. OVERVIEW OF LITERATURE: Several studies have compared the efficacy of pre- and postoperative administration of parecoxib, which led to inconclusive results owing to variation in operative time...
October 2018: Asian Spine Journal
Izabela Zakrocka, Katarzyna M Targowska-Duda, Artur Wnorowski, Tomasz Kocki, Krzysztof Jóźwiak, Waldemar A Turski
Significant body of evidence suggests that abnormal kynurenic acid (KYNA) level is involved in the pathophysiology of central nervous system disorders. In the brain, KYNA is synthesized from kynurenine (KYN) by kynurenine aminotransferases (KATs), predominantly by KAT II isoenzyme. Blockage of ionotropic glutamate (GLU) receptors is a main cellular effect of KYNA. High KYNA levels have been linked with psychotic symptoms and cognitive dysfunction in animals and humans. As immunological imbalance and impaired glutamatergic neurotransmission are one of the crucial processes in neurological pathologies, we aimed to analyze the effect of anti-inflammatory agents, inhibitors of cyclooxygenase-2 (COX-2): celecoxib, niflumic acid, and parecoxib, on KYNA synthesis and KAT II activity in rat brain in vitro...
September 3, 2018: Neurotoxicity Research
Jian-Guo Guo, Lu-Ping Zhao, Yue-Feng Rao, Yin-Ping Gao, Xue-Jiao Guo, Tan-Yang Zhou, Zhi-Ying Feng, Jun-Hui Sun, Xiao-Yang Lu
BACKGROUD: Transarterial chemoembolization (TACE) is the primary palliative treatment for patients with unresectable hepatocellular carcinoma (HCC). However, it is often accompanied by postoperative pain which hinder patient recovery. This study was to examine whether preemptive parecoxib and sufentanil-based patient controlled analgesia (PCA) could improve the pain management in patients receiving TACE for inoperable HCC. METHODS: From June to December 2016, 84 HCC patients undergoing TACE procedure were enrolled...
August 3, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Medicine (Baltimore)
D Dahlgren, C Roos, A Lundqvist, C Tannergren, M Sjöblom, E Sjögren, H Lennernäs
The small intestine mucosal barrier is physiologically regulated by the luminal conditions, where intestinal factors, such as diet and luminal tonicity, can affect mucosal permeability. The intestinal barrier may also be affected by absorption-modifying excipients (AME) in oral drug delivery systems. Currently, there is a gap in the understanding of how AMEs interact with the physiological regulation of intestinal electrolyte transport and fluid flux, and epithelial permeability. Therefore, the objective of this single-pass perfusion study in rat was to investigate the effect of three AMEs on the intestinal mucosal permeability at different luminal tonicities (100, 170, and 290 mOsm)...
October 5, 2018: International Journal of Pharmaceutics
Yong Yang, Xinyuan Lin, Ting Zeng, Yuanyuan Liu, Yong Li
OBJECTIVE: To observe the analgesic and sedative effects of acupuncture combined with local anesthesia for percutaneous vertebroplasty (PVP). METHODS: Sixty patients of single segmental osteoporotic vertebral compression fractures who were prepared to receive PVP were randomly divided into an observation group, a control 1 group, a control 2 group, 20 cases in each group. The patients in the observation group were treated with electroacupuncture (EA) at Hegu (LI 4), Neiguan (PC 6) and Zusanli (ST 36) 20 min before operation; during operation, EA was given combined with regular anesthesia...
July 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Ali Jendoubi, Wafa Aissi, Ahmed Abbes, Abderrazek Bouzouita, Sami Fourati, Hatem Necib, Salma Ghedira, Mohamed Houissa
Background and Aims: Catheter-related bladder discomfort (CRBD) is the urge to void or discomfort in the suprapubic region secondary to an indwelling urinary catheter. We aimed to evaluate the safety and efficacy of single-dose of intravenous parecoxib in reducing the incidence and severity of CRBD in patients undergoing transurethral resection of bladder tumor (TURBT). Methods: Sixty-one adult patients, American Society of Anesthesiologists physical status I or II, undergoing elective TURBT under spinal anaesthesia, were randomly allocated to receive 40 mg of IV parecoxib (group P; n = 29) or an equal volume of normal saline (control group C; n = 32)...
June 2018: Indian Journal of Anaesthesia
Kalyani B Sonawane, Ning Cheng, Richard A Hansen
BACKGROUND: Data on adverse drug events (ADEs) observed at the population level provide important evidence regarding the safety of a pharmaceutical product in real-world settings. Recent patterns in serious and fatal ADE reporting have not been documented. OBJECTIVE: To assess recent patterns in serious and fatal ADE reports in the United States. METHODS: We conducted a retrospective analysis of the publicly available 2006-2014 FDA Adverse Event Reporting System database...
July 2018: Journal of Managed Care & Specialty Pharmacy
Ugnė Čeponytė, Miglė Paškevičiūtė, Vilma Petrikaitė
Purpose: In this study, we evaluated the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) in BxPC-3 and MIA PaCa-2 pancreatic cancer cell cultures. Methods: To test the effect of compounds on the viability of cells, the MTT assay was used. The activity of NSAIDs in 3D cell cultures was evaluated by measuring the size change of spheroids. The type of cell death was identified by cell staining with Hoechst 33342 and propidium iodide. To evaluate the effect on the colony-forming ability of cancer cells, the clonogenic assay was used...
2018: Cancer Management and Research
Emanuela Ricciotti, Cecilia Castro, Soon Yew Tang, William T E Briggs, James A West, Dania Malik, Seth D Rhoades, Hu Meng, Xuanwen Li, Nicholas F Lahens, Jeffrey A Sparks, Elizabeth W Karlson, Aalim M Weljie, Julian L Griffin, Garret A FitzGerald
Background -Large scale, placebo controlled trials established that nonsteroidal anti-inflammatory drugs (NSAIDs) confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin (PGI2 ). An alternative mechanism by which NSAIDs might constrain cardioprotection is by enhancing the formation of methylarginines in the kidney that would limit the action of nitric oxide (NO) throughout the vasculature. Methods -Targeted and untargeted metabolomics were employed to investigate the effect of COX-2 deletion or inhibition in mice and in osteoarthritis (OA) patients exposed to NSAIDs on the L-arginine/NO pathway...
June 21, 2018: Circulation
Torill Kaasa, Luis Romundstad, Helge Roald, Knut Skolleborg, Audun Stubhaug
In this long-term follow-up study of 175 women, we investigated the prevalence of and factors associated with persisting pain and sensory changes four years after augmentation mammoplasty. Previously the women had participated in an acute postoperative pain study, and follow-up investigations at 6 weeks and 1 year after surgery. In the present study, the women were mailed questionnaires about pain, sensory changes, and affection of daily life, quality of life and pain catastrophizing 4 years after surgery. One hundred and sixteen women answered the questionnaire...
April 1, 2010: Scandinavian Journal of Pain
Elina Tiippana, Kaisa Nelskylä, Eija Nilsson, Eero Sihvo, Matti Kataja, Eija Kalso
Background and aims Thoracotomies can cause severe pain, which persists in 21-67% of patients. We investigated whether NSAID + intravenous patient-controlled analgesia (IV-PCA) with morphine is an efficacious alternative to thoracic epidural analgesia (TEA). We also wanted to find out whether an extended controlled pain management protocol within a clinical study can decrease the incidence of persistent post-thoracotomy pain. Methods Thirty thoracotomy patients were randomized into 3 intervention groups with 10 patients in each...
October 1, 2014: Scandinavian Journal of Pain
Maximilian Tufvesson-Alm, Lilly Schwieler, Robert Schwarcz, Michel Goiny, Sophie Erhardt, Göran Engberg
Kynurenine 3-monooxygenase (KMO) is an essential enzyme of the kynurenine pathway, converting kynurenine into 3-hydroxykynurenine. Inhibition of KMO increases kynurenine, resulting in elevated levels of kynurenic acid (KYNA), an endogenous N-methyl-d-aspartate and α*7-nicotinic receptor antagonist. The concentration of KYNA is elevated in the brain of patients with schizophrenia, possibly as a result of a reduced KMO activity. In the present study, using in vivo single cell recording techniques, we investigated the electrophysiological characteristics of ventral tegmental area dopamine (VTA DA) neurons and their response to antipsychotic drugs in a KMO knock-out (K/O) mouse model...
August 2018: Neuropharmacology
Xiaoliang Jin, Fang Zhou, Yan Liu, Chen Cheng, Lan Yao, Yuanwei Jia, Guangji Wang, Jingwei Zhang
Parecoxib (PX), a prodrug of valdecoxib (VX), is an injectable selective COX-2 inhibitor, and is recommended for the treatment of cancer pain. PX can be rapidly hydrolyzed into its active metabolite VX, and VX is further metabolized into hydroxylated valdecoxib (OH-VX) by cytochrome P450 enzymes. However, cancer patients have been reported to possess reduced drug metabolism ability, which might cause excessive drug accumulation. Such overdose of PX significantly increased the risk of renal safety and cardiovascular events...
September 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
Q B Li, L Chang, F Ye, Q H Luo, Y X Tao, H H Shu
BACKGROUND: Accumulated evidence suggests that spinal cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) may be implicated in the development of opioid-induced hyperalgesia. METHODS: Rats received subcutaneous fentanyl injections at different doses (20-80 μg kg-1 ), four separate times at 15-min intervals. Some rats only received fentanyl (60 μg kg-1  × 4 doses) with or without surgical incision. Fentanyl-induced hyperalgesia was evaluated via a tail-pressure or paw-withdrawal test...
April 2018: British Journal of Anaesthesia
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