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https://www.readbyqxmd.com/read/29451955/relationship-between-subchondral-bone-microstructure-and-articular-cartilage-in-the-osteoarthritic-knee-using-3t-mri
#1
Chenglei Liu, Chang Liu, Liping Si, Hao Shen, Qian Wang, Weiwu Yao
BACKGROUND: The importance of subchondral bone in the pathogenesis of osteoarthritis (OA) has drawn interest. PURPOSE: To investigate subregional trabecular bone microstructural features and to determine the relationship between cartilage and trabecular bone in the osteoarthritic human knee. STUDY TYPE: Prospective study. SUBJECTS: In all, 92 knees were enrolled and divided into three groups: without OA, mild OA, and severe OA...
February 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29451323/-18f-av-1451-tau-pet-and-primary-progressive-aphasia
#2
Keith A Josephs, Peter R Martin, Hugo Botha, Christopher G Schwarz, Joseph R Duffy, Heather M Clark, Mary M Machulda, Jonathan Graff-Radford, Stephen D Weigand, Matthew L Senjem, Rene L Utianski, Daniel A Drubach, Bradley F Boeve, David T Jones, David S Knopman, Ronald C Petersen, Clifford R Jack, Val J Lowe, Jennifer L Whitwell
OBJECTIVES: To assess [ 18 F]AV-1451 tau-PET uptake patterns across the primary progressive aphasia (PPA) variants (logopenic, semantic and agrammatic), examine regional uptake patterns of [ 18 F]AV-1451 independent of clinical diagnosis, and compare the diagnostic utility of [ 18 F]AV-1451, [ 18 F]-fluorodeoxygluclose (FDG)-PET and MRI to differentiate the PPA variants. METHODS: We performed statistical parametric mapping of [ 18 F]AV-1451 across 40 PPA patients (logopenic-PPA=14, semantic-PPA=13 and agrammatic-PPA=13) compared to 80 cognitively normal, PiB-negative controls, age and gender matched 2:1...
February 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29450848/automated-pathogenesis-based-diagnosis-of-lumbar-neural-foraminal-stenosis-via-deep-multiscale-multitask-learning
#3
Zhongyi Han, Benzheng Wei, Stephanie Leung, Ilanit Ben Nachum, David Laidley, Shuo Li
Pathogenesis-based diagnosis is a key step to prevent and control lumbar neural foraminal stenosis (LNFS). It conducts both early diagnosis and comprehensive assessment by drawing crucial pathological links between pathogenic factors and LNFS. Automated pathogenesis-based diagnosis would simultaneously localize and grade multiple spinal organs (neural foramina, vertebrae, intervertebral discs) to diagnose LNFS and discover pathogenic factors. The automated way facilitates planning optimal therapeutic schedules and relieving clinicians from laborious workloads...
February 15, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29449909/alterations-in-the-inferior-longitudinal-fasciculus-in-autism-and-associations-with-visual-processing-a-diffusion-weighted-mri-study
#4
Bart Boets, Lien Van Eylen, Kevin Sitek, Pieter Moors, Ilse Noens, Jean Steyaert, Stefan Sunaert, Johan Wagemans
Background: One of the most reported neural features of autism spectrum disorder (ASD) is the alteration of multiple long-range white matter fiber tracts, as assessed by diffusion-weighted imaging and indexed by reduced fractional anisotropy (FA). Recent methodological advances, however, have shown that this same pattern of reduced FA may be an artifact resulting from excessive head motion and poorer data quality and that aberrant structural connectivity in children with ASD is confined to the right inferior longitudinal fasciculus (ILF)...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29449817/clinical-factors-associated-with-brain-volume-reduction-in-systemic-lupus-erythematosus-patients-without-major-neuropsychiatric-manifestations
#5
Shuang Liu, Yuqi Cheng, Yueyin Zhao, Hongjun Yu, Aiyun Lai, Zhaoping Lv, Xiufeng Xu, Chunrong Luo, Baoci Shan, Lin Xu, Jian Xu
The aim of the study was to find structural brain changes in systemic lupus erythematosus patients without major neuropsychiatric manifestations [non-neuropsychiatric systemic lupus erythematosus (non-NPSLE)] using quantitative magnetic resonance imaging (MRI) and possible associations with clinical characteristics. 89 non-NPSLE patients with normal conventional MRI and 84 healthy controls (HCs) were recruited. The whole brain gray matter volume (GMV) and white matter volume (WMV) were calculated for each individual...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29449186/the-reorganization-of-functional-architecture-in-the-early-stages-of-parkinson-s-disease
#6
Noora Tuovinen, Klaus Seppi, Francesco de Pasquale, Christoph Müller, Michael Nocker, Michael Schocke, Elke R Gizewski, Christian Kremser, Gregor K Wenning, Werner Poewe, Atbin Djamshidian, Christoph Scherfler, Morinobu Seki
INTRODUCTION: The study aim was to identify longitudinal abnormalities of functional connectivity and its relation with motor disability in early to moderately advanced stages of Parkinson's disease patients. METHODS: 3.0T structural and resting-state functional MRI was performed in healthy subjects (n = 16) and Parkinson's disease patients (n = 16) with mean disease duration of 2.2 ± 1.2 years at baseline with a clinical follow-up of 1.5 ± 0.3 years. Resting-state fMRI analysis included region-to-region connectivity in correlation with UPDRS-III scores and computation of Global Efficiency and Degree Centrality...
February 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29448926/histologic-chorioamnionitis-in-preterm-infants-correlation-with-brain-magnetic-resonance-imaging-at-term-equivalent-age
#7
Claire Granger, Alicia J Spittle, Jennifer Walsh, Jan Pyman, Peter J Anderson, Deanne K Thompson, Katherine J Lee, Lee Coleman, Charuta Dagia, Lex W Doyle, Jeanie Cheong
BACKGROUND: To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age. METHODS: Preterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation)...
February 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29448082/large-enthesophytes-in-teenage-skulls-mechanical-inflammatory-and-genetic-considerations
#8
David Shahar, John Evans, Mark G L Sayers
BACKGROUND: The literature implies that large enthesophytes are exclusive to genetically predisposed individuals and to Spondyloarthropathies sufferers. Accordingly, the aim of this investigation and report was to assess the involvement of genetic predisposition, inflammatory and/or mechanical influences in the development of large enthesophytes in a sample population of teenagers presenting with large enthesophytes emanating from the external occipital protuberance. METHODS: Analysis was based on four teenage males (13-16 year-old) possessing 14...
February 12, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29448074/a-probabilistic-approach-to-discovering-dynamic-full-brain-functional-connectivity-patterns
#9
REVIEW
Jeremy R Manning, Xia Zhu, Theodore L Willke, Rajesh Ranganath, Kimberly Stachenfeld, Uri Hasson, David M Blei, Kenneth A Norman
Recent research shows that the covariance structure of functional magnetic resonance imaging (fMRI) data - commonly described as functional connectivity - can change as a function of the participant's cognitive state (for review see (Turk-Browne, 2013)). Here we present a Bayesian hierarchical matrix factorization model, termed hierarchical topographic factor analysis (HTFA), for efficiently discovering full-brain networks in large multi-subject neuroimaging datasets. HTFA approximates each subject's network by first re-representing each brain image in terms of the activities of a set of localized nodes, and then computing the covariance of the activity time series of these nodes...
February 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29448073/neurite-imaging-reveals-microstructural-variations-in-human-cerebral-cortical-gray-matter
#10
Hikaru Fukutomi, Matthew F Glasser, Hui Zhang, Joonas A Autio, Timothy S Coalson, Tomohisa Okada, Kaori Togashi, David C Van Essen, Takuya Hayashi
We present distinct patterns of neurite distribution in the human cerebral cortex using diffusion magnetic resonance imaging (MRI). We analyzed both high-resolution structural (T1w and T2w images) and diffusion MRI data in 505 subjects from the Human Connectome Project. Neurite distributions were evaluated using the neurite orientation dispersion and density imaging (NODDI) model, optimized for gray matter, and mapped onto the cortical surface using a method weighted towards the cortical mid-thickness to reduce partial volume effects...
February 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29448003/increased-hippocampal-prefrontal-functional-connectivity-in-insomnia
#11
Jeanne Leerssen, Rick Wassing, Jennifer R Ramautar, Diederick Stoffers, Oti Lakbila-Kamal, Joy Perrier, Jessica Bruijel, Jessica C Foster-Dingley, Moji Aghajani, Eus J W van Someren
Insomnia Disorder (ID) is the second-most common mental disorder and has a far-reaching impact on daytime functioning. A meta-analysis indicates that, of all cognitive domains, declarative memory involving the hippocampus is most affected in insomnia. Hippocampal functioning has consistently been shown to be sensitive to experimental sleep deprivation. Insomnia however differs from sleep deprivation in many aspects, and findings on hippocampal structure and function have been equivocal. The present study used both structural and resting-state functional Magnetic Resonance Imaging in a larger sample than previously reported to evaluate hippocampal volume and functional connectivity in ID...
February 12, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29446726/metal-organic-framework-mof-based-nanomaterials-for-biomedical-applications
#12
Zhidong Luo, Shuran Fan, Chuying Gu, Weicong Liu, Baohong Li, Jianqiang Liu
Metal-organic frameworks (MOFs) are compounds consisting of metal ions or clusters coordinated to organic ligands to form one-, two-, or three-dimensional structures. They are a subclass of coordination polymers (CPs), with the special feature that they are often porous. The organic ligands are sometimes referred to as second building structs. The new porous materials have paid great attention because of the variety of advantages such as tunable components, structural diversity, high loading performance and favorable biodegradability...
February 14, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29446125/feasibility-of-high-spatiotemporal-resolution-for-an-abbreviated-3d-radial-breast-mri-protocol
#13
Jorge E Jimenez, Roberta M Strigel, Kevin M Johnson, Leah C Henze Bancroft, Scott B Reeder, Walter F Block
PURPOSE: To develop a volumetric imaging technique with 0.8-mm isotropic resolution and 10-s/volume rate to detect and analyze breast lesions in a bilateral, dynamic, contrast-enhanced MRI exam. METHODS: A local low-rank temporal reconstruction approach that also uses parallel imaging and spatial compressed sensing was designed to create rapid volumetric frame rates during a contrast-enhanced breast exam (vastly undersampled isotropic projection [VIPR] spatial compressed sensing with temporal local low-rank [STELLR])...
February 14, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29445514/exploring-computerised-cognitive-training-as-a-therapeutic-intervention-for-people-with-huntington-s-disease-cogtrainhd-protocol-for-a-randomised-feasibility-study
#14
Emma Yhnell, Hannah Furby, Rachel S Breen, Lucy C Brookes-Howell, Cheney J G Drew, Rebecca Playle, Gareth Watson, Claudia Metzler-Baddeley, Anne E Rosser, Monica E Busse
Background: Cognitive impairments, especially deficits of executive function, have been well documented as a core and early feature in Huntington's disease (HD). Cognitive impairments represent considerable burden and can be devastating for people and families affected by HD. Computerised cognitive training interventions that focus on improving executive function present a possible non-pharmacological treatment option. We propose to determine the feasibility, acceptability, and appropriate outcome measures for use in a randomised controlled feasibility study...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29444467/olfactory-function-in-systemic-lupus-erythematosus-and-systemic-sclerosis-a-longitudinal-study-and-review-of-the-literature
#15
REVIEW
Mariana Freschi Bombini, Fernando Augusto Peres, Aline Tamires Lapa, Nailú Angélica Sinicato, Beatriz Ricato Quental, Ágatha de Souza Melo Pincelli, Tiago Nardi Amaral, Caroline Cristina Gomes, Ana Paula Del Rio, João Francisco Marques-Neto, Lilian T L Costallat, Paula Teixeira Fernandes, Fernando Cendes, Leticia Rittner, Simone Appenzeller
BACKGROUND/PURPOSE: To evaluate olfactory function in systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and healthy controls over a 2-year period, and to determine the association of olfactory dysfunction with age, disease activity, disease damage, treatment, anxiety and depression symptoms and limbic structures volumes. METHODS: Consecutive SLE and SSc patients were enrolled in this study. Clinical, laboratory disease activity and damage were assessed according to diseases specific guidelines...
February 11, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29442273/a-comparative-study-of-segmentation-techniques-for-the-quantification-of-brain-subcortical-volume
#16
Theophilus N Akudjedu, Leila Nabulsi, Migle Makelyte, Cathy Scanlon, Sarah Hehir, Helen Casey, Srinath Ambati, Joanne Kenney, Stefani O'Donoghue, Emma McDermott, Liam Kilmartin, Peter Dockery, Colm McDonald, Brian Hallahan, Dara M Cannon
Manual tracing of magnetic resonance imaging (MRI) represents the gold standard for segmentation in clinical neuropsychiatric research studies, however automated approaches are increasingly used due to its time limitations. The accuracy of segmentation techniques for subcortical structures has not been systematically investigated in large samples. We compared the accuracy of fully automated [(i) model-based: FSL-FIRST; (ii) patch-based: volBrain], semi-automated (FreeSurfer) and stereological (Measure®) segmentation techniques with manual tracing (ITK-SNAP) for delineating volumes of the caudate (easy-to-segment) and the hippocampus (difficult-to-segment)...
February 13, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29442234/microstructural-changes-in-patients-with-parkinson-disease-and-rem-sleep-behavior-disorder-depressive-symptoms-versus-non-depressed
#17
Farzaneh Ghazi Sherbaf, Farzaneh Rahmani, Sommayeh Mohammadi Jooyandeh, Mohammad Hadi Aarabi
Search for Parkinson's disease (PD) progression biomarkers has led to the identification of both motor and non-motor symptoms relevant of prodromal PD that could be eye-opening to the spreading underlying Lewy body pathogenesis. One most robust predictor of PD is the REM sleep behavior disorder (RBD), and one most common early non-motor symptom of PD is depression. With RBD, frequently coexisting with clinical depression and both predicting dopamine transmission dysfunction, we aimed to survey structural associates of depressive symptoms in early PD patients with comorbid RBD...
February 13, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29442191/measurement-and-implications-of-the-distance-between-the-sphenopalatine-ganglion-and-nasal-mucosa-a-neuroimaging-study
#18
Joan Crespi, Daniel Bratbak, David Dodick, Manjit Matharu, Kent Are Jamtøy, Irina Aschehoug, Erling Tronvik
BACKGROUND: Historical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sphenopalatine foramen (SPF) which is hypothesized to diffuse a distance as short as 1 mm. Nonetheless, the SPG is located in the sphenopalatine fossa, encapsulated in connective tissue, surrounded by fat tissue and separated from the nasal cavity by a bony wall. The sphenopalatine fossa communicates with the nasal cavity through the SPF, which contains neurovascular structures packed with connective tissue and is covered by mucosa in the nasal cavity...
February 13, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29442181/do-functional-outcomes-and-cuff-integrity-correlate-after-single-versus-double-row-rotator-cuff-repair-a-systematic-review-and-meta-analysis-study
#19
Mohamed H Sobhy, Ahmed Hany Khater, Medhat Ragab Hassan, Ossama El Shazly
PURPOSE: The purpose of this study is to perform a systematic review and meta-analysis of all available level I prospective randomized controlled trials comparing arthroscopic single-row (SR) with double-row (DR) rotator cuff repairs by both clinical outcomes and radiological re-tear rates. METHODS: PubMed, EMBASE, Google Scholar, and Cochrane databases search was done for level I RCTs comparing clinical and radiological outcomes after SR versus DR rotator cuff repair...
February 13, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29440429/locus-coeruleus-integrity-in-old-age-is-selectively-related-to-memories-linked-with-salient-negative-events
#20
Dorothea Hämmerer, Martina F Callaghan, Alexandra Hopkins, Julian Kosciessa, Matthew Betts, Arturo Cardenas-Blanco, Martin Kanowski, Nikolaus Weiskopf, Peter Dayan, Raymond J Dolan, Emrah Düzel
The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity varies considerably across healthy older individuals, and is suggested to contribute to altered cognitive functions in aging. Here we test this hypothesis using an incidental memory task that is known to be susceptible to noradrenergic modulation. We used MRI neuromelanin (NM) imaging to assess LC structural integrity and pupillometry as a putative index of LC activation in both younger and older adults. We show that older adults with reduced structural LC integrity show poorer subsequent memory...
February 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
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