Read by QxMD icon Read

spinal pathology

Łukasz Przepiórka, Przemysław Kunert, Paulina Juszyńska, Michał Zawadzki, Bogdan Ciszek, Mariusz Głowacki, Andrzej Marchel
Spinal dural arteriovenous fistula (SDAVF) is the most common vascular malformation of the spine in adults. However, the coincidence of tethered cord syndrome, lipoma, and SDAVF on the sacral level is exceptionally rare. We describe two patients, probably the fifth and sixth ever reported. The first was a 33 year-old female who underwent surgical cord de-tethering. Surprisingly, a sacral SDAVF was discovered intraoperatively, despite negative digital subtraction angiography (DSA). The second patient was a 30 year-old male with similar pathologies...
2018: Frontiers in Neurology
Babu Peter Sathyanathan, Bharathi Priya Raju, Kailasanathan Natarajan, Ravi Ranganathan
Objective: The objective of this study was to evaluate intramedullary spinal cord lesions using magnetic resonance spectroscopy and correlate the results with histo-pathological examination (HPE). Materials and Methods: Approval for this study was obtained from our institute ethical committee. Overall, 50 patients were recruited (29 male and 21 female) , with a maximum age of 53 years and minimum age of 7 years. The mean age group of the study was 33 years. Standard magnetic resonance imaging (MRI) spine was done on a Siemens Skyra 3Tesla MRI scanner...
July 2018: Indian Journal of Radiology & Imaging
Yuyao Zhang, Jingjing Shi, Hongjiang Wei, Victor Han, Wen-Zhen Zhu, Chunlei Liu
The human brain rapidly develops during the first two years following birth. Quantitative susceptibility mapping (QSM) provides information of iron and myelin variations. It is considered to be a valuable tool for studying brain development in early life. In the present work, QSM is performed on neonates, 1-year and 2-year old infants, as well as a group of adults for the purpose of reference. Age-specific templates representing common brain structures are built for each age group. The neonate and infant QSM templates have shown some unique findings compared to conventional T1w and T2w imaging techniques...
October 10, 2018: NeuroImage
Dong-Kyun Seo, Sookyung Lee, Gunn Lee, Myung-Su Lee, Syn-Hae Yoon, Seong-Soo Choi, Jin-Woo Shin
A previous study showed that transforaminal balloon adhesiolysis via the safe triangle was effective in lumbar spinal stenosis. However, retrodiscal pathology is difficult to treat with this method. Therefore we attempted retrodiscal balloon adhesiolysis via Kambin's triangle. The design of our study is a retrospective analysis. The setting of our study is a tertiary, interventional pain management practice, speciality referral center.The primary indication for this procedure is radicular pain arising from ipsilateral retrodiscal pathology...
October 2018: Medicine (Baltimore)
Zhe-Hui Wang, Yuan-Tao Wang, Fei Cheng, Yu Hu
INTRODUCTION: This study aims to investigate the pathological features of a patient with paraganglioma in the lumbar spinal canal. CASE PRESENTATION: The patient was 36 years old male with electrical pain in the waist and buttock which occurred intermittently, and was not relieved under oral use of analgesics. Immunohistochemical staining was performed to diagnose the disease. The results revealed that the size of the tumor was 3.4 × 1.6 × 1.4 cm. The hematoxylin and eosin (H&E)-stained tumor cells mainly presented with an organ-like arrangement under low power microscope, showing prominent chrysanthemum-like, pseudo glandular or pseudo papillary arrangements...
October 2018: Medicine (Baltimore)
Tamir Ailon, Jin Tee, Neil Manson, Hamilton Hall, Ken Thomas, Y Raja Rampersaud, Albert Yee, Nicolas Dea, Andrew Glennie, Chris Bailey, Sean Christie, Michael H Weber, Andrew Nataraj, Jerome Paquet, Mike Johnson, Jonathan Norton, Henry Ahn, Greg McIntosh, Charles G Fisher
STUDY DESIGN: Retrospective review of results from a prospectively collected Canadian cohort in comparison to published literature. OBJECTIVES: (1) To investigate whether patients in a universal health care system (HCS) have different outcomes than those in a multi-tier HCS in surgical management of degenerative spondylolisthesis (DS). (2) To identify independent factors predictive of outcome in surgical DS patients. SUMMARY OF BACKGROUND DATA: Canada has a national health insurance program with unique properties...
October 9, 2018: Spine Journal: Official Journal of the North American Spine Society
Go Yoshida, Muneharu Ando, Shiro Imagama, Shigenori Kawabata, Kei Yamada, Tsukasa Kanchiku, Yasushi Fujiwara, Nobuaki Tadokoro, Masahito Takahashi, Kanichiro Wada, Naoya Yamamoto, Sho Kobayashi, Hiroki Ushirozako, Kazuyoshi Kobayashi, Akimasa Yasuda, Kenichi Shinomiya, Toshikazu Tani, Yukihiro Matsuyama
STUDY DESIGN: Prospective multicenter study OBJECTIVE.: To analyze the incidence of intraoperative spinal neuromonitoring (IONM) alerts and neurological complications, as well as to determine which interventions are most effective at preventing postoperative neurological complications following IONM alerts in high risk spinal surgeries. SUMMARY OF BACKGROUND DATA: IONM may play a role in identifying and preventing neural damage; however, few studies have clarified the outcomes of intervention after IONM alerts...
October 11, 2018: Spine
Elizabeth A Rapp van Roden, Robert Tyler Richardson, Stephanie A Russo, William C Rose, Kristen F Nicholson, Ross S Chafetz, Peter G Gabos, Suken A Shah, Amer F Samdani, James G Richards
BACKGROUND: Nonsurgically treated patients with AIS demonstrate altered scapular kinematics and decreased patient-reported shoulder function compared with typically developing adolescents. It is unknown whether surgical correction of the spine deformity has beneficial or detrimental effects on scapulothoracic joint function, as previous assessments of shoulder function following surgery have only focused on humerothoracic motion. The objective of this study was to perform a comprehensive analysis of scapular kinematics before and after PSF and compare postoperative scapular kinematics in AIS to those of a typically developing cohort...
October 11, 2018: Journal of Pediatric Orthopedics
Tadeusz Mikołajczyk, Adam Kłodowski, Emilia Mikołajewska, Paweł Walkowiak, Pedro Berjano, Jorge Hugo Villafañe, Francesco Aggogeri, Alberto Borboni, Davide Fausti, Gianluigi Petrogalli
BACKGROUND: The use of an exoskeleton elbow is considered an effective treatment in several pathologies, including post-stroke complications, traumatic brain injury (TBI) and spinal cord injury (SCI), as well as in patients with neurodegenerative disorders. The effectiveness of rehabilitation is closely linked to a suitably chosen therapy. The treatment can be performed only by specialized personnel, significantly supported by the use of automated devices. OBJECTIVES: The aim of this study was to present a novel exoskeleton for elbow rehabilitation without a complicated control system...
October 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Krishnan V Chakravarthy, Fang Xing, Kelly Bruno, Alexander R Kent, Adil Raza, Rene Hurlemann, Thomas M Kinfe
BACKGROUND: There is increasing literature evidence both clinically and experimentally on the existence of potent, adaptive interactions between the central and peripheral aspects of the neuroimmune system in the genesis and maintenance of chronic neuropathic extremity pain and nociceptive back pain. The neuroinflammatory pathways are modulated by the interaction of pro- and anti-inflammatory cytokines and chemokines, which are released by peripheral immune system-derived cell species (macrophages and leukocytes)...
October 12, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Xiongsong Lu, Pengfei Xue, Luyu Fu, Jinlong Zhang, Jiawei Jiang, Xiaofeng Guo, Guofeng Bao, Guanhua Xu, Yuyu Sun, Jiajia Chen, Zhiming Cui
HS1-associated protein X-1 (HAX1) is a class of multifunctional protein, participated in various physiological processes such as cell apoptosis, proliferation and motility. However, the HAX1 expression and function in the spinal cord injury (SCI) pathological process have not been investigated. In our current research, the rat model of SCI was established, and then we explored the possible role of HAX1 after SCI. The results of western blot indicated that HAX1 was present in sham operated control group and significantly elevated at 3 days post SCI, then declined gradually...
October 2018: Tissue & Cell
Kaveri Arora, Jeffrey M Sequeira, Juan M Alarcon, Brandi Wasek, Erland Arning, Teodoro Bottiglieri, Edward V Quadros
In humans, vitamin B12 deficiency causes peripheral and CNS manifestations. Loss of myelin in the peripheral nerves and the spinal cord (SC) contributes to peripheral neuropathy and motor deficits. The metabolic basis for the demyelination and brain disorder is unknown. The transcobalamin receptor-knockout mouse ( Cd320-/- ) develops cobalamin (Cbl) deficiency in the nervous system, with mild anemia. A decreased S-adenosylmethionine: S-adenosylhomocysteine ratio and increased methionine were seen in the brain with no significant changes in neurotransmitter metabolites...
October 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Charley Gros, Benjamin De Leener, Atef Badji, Josefina Maranzano, Dominique Eden, Sara M Dupont, Jason Talbott, Ren Zhuoquiong, Yaou Liu, Tobias Granberg, Russell Ouellette, Yasuhiko Tachibana, Masaaki Hori, Kouhei Kamiya, Lydia Chougar, Leszek Stawiarz, Jan Hillert, Elise Bannier, Anne Kerbrat, Gilles Edan, Pierre Labauge, Virginie Callot, Jean Pelletier, Bertrand Audoin, Henitsoa Rasoanandrianina, Jean-Christophe Brisset, Paola Valsasina, Maria A Rocca, Massimo Filippi, Rohit Bakshi, Shahamat Tauhid, Ferran Prados, Marios Yiannakas, Hugh Kearney, Olga Ciccarelli, Seth Smith, Constantina Andrada Treaba, Caterina Mainero, Jennifer Lefeuvre, Daniel S Reich, Govind Nair, Vincent Auclair, Donald G McLaren, Allan R Martin, Michael G Fehlings, Shahabeddin Vahdat, Ali Khatibi, Julien Doyon, Timothy Shepherd, Erik Charlson, Sridar Narayanan, Julien Cohen-Adad
The spinal cord is frequently affected by atrophy and/or lesions in multiple sclerosis (MS) patients. Segmentation of the spinal cord and lesions from MRI data provides measures of damage, which are key criteria for the diagnosis, prognosis, and longitudinal monitoring in MS. Automating this operation eliminates inter-rater variability and increases the efficiency of large-throughput analysis pipelines. Robust and reliable segmentation across multi-site spinal cord data is challenging because of the large variability related to acquisition parameters and image artifacts...
October 6, 2018: NeuroImage
George Grammatopoulos, Wade Gofton, Zaid Jibri, Matthew Coyle, Johanna Dobransky, Cheryl Kreviazuk, Paul R Kim, Paul E Beaulé
BACKGROUND: Many patients undergo both THA and spinal arthrodesis, and those patients may not fare as well as those who undergo one procedure but not the other. The mechanisms of how spinal arthrodesis affects patient function after THA remain unclear. QUESTIONS/PURPOSES: The aims of our study were to (1) determine how patient-reported outcome measures (PROMs), including the Oxford hip score as well as dislocations and complications compare after THA between patients with and without spinal arthrodesis; (2) characterize sagittal pelvic changes in these patients that occur when moving between different functional positions and test for differences between patients with and without spinal arthrodesis; and (3) assess whether differences in sagittal pelvic dynamics are associated with PROMs, complications, and dislocations after THA...
May 30, 2018: Clinical Orthopaedics and related Research
Gabriel S Walt, Hannah M Burris, Christopher B Brady, Keith R Spencer, Victor E Alvarez, Bertrand R Huber, Latease Guilderson, Nazifa Abdul Rauf, Derek Collins, Tarnjit Singh, Rebecca Mathias, James G Averill, Sean E Walker, Ian Robey, Ann C McKee, Neil W Kowall, Thor D Stein
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder linked to repetitive head impacts and has been associated with amyotrophic lateral sclerosis (ALS), a fatal, degenerative neuromuscular disorder. The Department of Veterans Affairs Biorepository Brain Bank (VABBB) is a tissue repository that collects antemortem disease progression data and postmortem central nervous system tissue from veterans with ALS. We set out to determine the frequency of co-morbid ALS and CTE in the VABBB cohort and to characterize the clinical, genetic, and pathological distinctions between participants with ALS only and those with both ALS and CTE (ALS+CTE)...
October 9, 2018: Journal of Neuropathology and Experimental Neurology
Adrianna Z Herskovits, Tegan A Hunter, Nicholas Maxwell, Katherine Pereira, Charles A Whittaker, Gregorio Valdez, Leonard P Guarente
SIRT1 is an NAD+ -dependent deacetylase that functions in a variety of cells and tissues to mitigate age-associated diseases. However, it remains unknown if SIRT1 also acts to prevent pathological changes that accrue in motor neurons during aging and amyotrophic lateral sclerosis (ALS). In this study, we show that SIRT1 expression decreases in the spinal cord of wild-type mice during normal aging. Using mouse models either overexpressing or lacking SIRT1 in motor neurons, we found that SIRT1 slows age-related degeneration of motor neurons' presynaptic sites at neuromuscular junctions (NMJs)...
October 8, 2018: Aging Cell
Courtney E Baker, Tanya Marvi, Thomas M Austin, Shelby Payne, Megan E Mignemi, David Gailani, Allison P Wheeler, Thanh T Nguyen, Steven A Lovejoy, Jeffrey E Martus, Gregory A Mencio, Jonathan G Schoenecker
BACKGROUND: Children undergoing posterior spinal fusion experience high blood loss often necessitating transfusion. An appropriately activated coagulation system provides hemostasis during surgery, but pathologic dysregulation can cause progressive bleeding and increased transfusions. Despite receiving antifibrinolytics for clot stabilization, many patients still require transfusions. AIMS: We sought to examine the association of dilutional coagulopathy with blood loss and blood transfusion in posterior spinal fusion for pediatric scoliosis patients...
October 8, 2018: Paediatric Anaesthesia
Kali Xu, Kay T Khine, Yinn Cher Ooi, Carolyn S Quinsey
Extraneural metastasis (ENM) of primary central nervous system (CNS) tumors is an uncommon occurrence. Case reports and case series describe ENM after shunting, but this phenomenon has not been well characterized. In this review we aim to better understand the risk factors and clinical implications of ENM associated with shunting. A literature search of cases of ENM related to shunt placement in patients with primary CNS tumors reported through January 2018 was performed using PubMed and Google Scholar. We identified 106 cases of ENM of primary CNS tumors related to shunt placement...
September 27, 2018: Clinical Neurology and Neurosurgery
Keisuke Takai, Manabu Niimura, Hiroki Hongo, Motoyuki Umekawa, Akio Teranishi, Tomomichi Kayahara, Makoto Taniguchi
OBJECTIVE: The diagnosis and treatment of intracranial hypotension associated with a spinal cerebrospinal fluid (CSF) leak, especially in comatose patients, have yet to be established. METHODS: Clinical manifestations, neuroimaging findings, and treatment outcomes in 11 patients (Glasgow Coma Scale 10±4) were described and compared with 36 patients with normal consciousness. RESULTS: Patients with disturbed consciousness were diagnosed at a significantly older age (55±11 years; p<0...
October 4, 2018: World Neurosurgery
P Lockwood, G Dolbear
INTRODUCTION: The aim of the study was to evaluate the performance of radiographers in image interpretation of magnetic resonance imaging (MRI) brain, spine and knee examinations following a nine-month work based postgraduate MRI module. METHODS: Twenty-seven participants each submitted 60 image commentaries taken from prospective clinical workloads. The image interpretations (n = 1620) comprised brain, spine, and knee MRI examinations. Prevalence of abnormal examinations approximated 53% (brain), 74% (spine), and 73% (knee), and included acute and chronic pathology, normal variants and incidental findings...
November 2018: Radiography
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"