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Post inflammatory hyperpigmentation

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https://www.readbyqxmd.com/read/30497518/effect-of-urea-extracted-sericin-on-melanogenesis-potential-applications-in-post-inflammatory-hyperpigmentation
#1
Pornanong Aramwit, Natthanej Luplertlop, Tapanee Kanjanapruthipong, Sumate Ampawong
BACKGROUND: Hyperpigmentation disorders such as post-inflammatory hyperpigmentation are major concerns not only in light-skinned people but also in Asian populations with darker skin. The anti-tyrosinase and immunomodulatory effects of sericin have been known for decades. However, the therapeutic effects of sericin on hyperpigmentation disorders have not been well documented. METHODS: In this study, we used an in vitro model to study the anti-tyrosinase, tolerogenic, and anti-melanogenic effects of sericin on Staphylococcus aureus peptidoglycan (PEG)-stimulated melanocytes, dendritic cells (DCs), and artificial skin (MelanoDerm™)...
November 29, 2018: Biological Research
https://www.readbyqxmd.com/read/30481955/clinical-evaluation-of-safety-and-efficacy-of-fractional-radiofrequency-facial-treatment-of-skin-type-vi-patients
#2
Eliot Battle, Sally Battle
INTRODUCTION: It has been well established that patients with darker skin types (Fitzpatrick skin types IV-VI) have an increased incidence of thermal induced side effects from laser and radio frequency (RF) treatments. Complications include a higher risk of post-inflammatory hyperpigmentation, hypopigmentation, and scarring, leading to unsatisfactory clinical outcomes. Fractional technologies improve the safety when treating patients with skin of color by treating only fractions of the skin while leaving a healing reservoir of untreated skin that improves the healing process...
November 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/30481954/hybrid-fractional-laser-a-multi-center-trial-on-the-safety-and-efficacy-for-photorejuvenation
#3
Jill Waibel, Jason Pozner, Christopher Robb, Elizabeth Tanzi
BACKGROUND: Laser skin resurfacing has continued to evolve over the past two decades. One of the most recent advances included a hybrid fractional laser resurfacing system that can sequentially utilize two wavelengths in its delivery, non-ablative coagulation with 1470 nm, and ablative vaporization with 2940 nm. The 1470 nm laser wavelength is absorbed by water, which is ideal for creating controlled zones of coagulation to chosen depths into the dermis up to 700 micrometers. The 2940 nm laser wavelength has a large water absorption coefficient, which results in precise ablation as desired in the epidermis up to 110 micrometers...
November 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/30481953/the-safety-of-laser-skin-resurfacing-with-the-microablative-carbon-dioxide-laser-and-review-of-the-literature
#4
Deborah Sarnoff, Robert Gotkin, Laura Doerfler, Cheryl Gustafson, C William Hanke
OBJECTIVE: The aim of this study was to evaluate the incidence of adverse effects following laser skin resurfacing with the microablative carbon dioxide (CO2) laser system (SmartXide DOT; DEKA, Calenzano, Italy). METHODS: A retrospective chart review was performed. Data was collected for DOT laser procedures performed at three clinical centers from 2008-2014. Results: Of the 1,081 DOT laser procedures, there were 13 complications (1.3% of all cases), which included eleven cases of prolonged erythema and two cases of post-inflammatory hyperpigmentation...
November 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/30426810/survey-of-acne-related-post-inflammatory-hyperpigmentation-in-the-middle-east
#5
A Abanmi, M Al-Enezi, A Al Hammadi, I Galadari, A-G Kibbi, S Zimmo
Acne vulgaris is a common inflammatory skin disease in the Middle East, similar to other regions of the world. In the Middle East, there is a relatively high proportion of patients with darker pigmentation (Fitzgerald skin types III-VI) who are prone to developing post-inflammatory hyperpigmentation (PIH) as a sequela of acne. Data are sparse on the frequency and characteristics of PIH throughout the world. What information is available indicates that pigmentation problems can be very bothersome for patients and are often quite long-lasting...
November 14, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/30365592/treatment-of-moderate-acne-vulgaris-in-fitzpatrick-skin-type-v-or-vi-efficacy-and-tolerability-of-fixed-combination-clindamycin-phosphate-1-2-benzoyl-peroxide-3-75-gel
#6
Laetitia Amar, Leon H Kircik
BACKGROUND: Acne vulgaris (acne) is the most common skin disease in patients who have darker skin with most frequent sequelae of post inflammatory hyperpigmentation (PIH). METHODS: Open label study in 20 patients (mean age 32 years) with Fitzpatrick Skin Type V or VI and with moderate facial acne treated with clindamycin phosphate 1.2%/benzoyl peroxide 3.75% gel (CL-BP 3.75%) once-daily for 16 weeks. Assessments included improvement in Investigator Global Assessment (IGA) of acne severity, PIH severity and distribution, and lesion count reduction...
October 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/30357871/evaluation-of-the-safety-and-efficacy-of-the-dual-wavelength-picosecond-laser-for-the-treatment-of-benign-pigmented-lesions-in-asians
#7
Ka-Yee Kung, Samantha Y-N Shek, Chi K Yeung, Henry H-L Chan
BACKGROUND AND OBJECTIVES: Cutaneous pigmentary disorders are both more common and more difficult to treat in patients with skin color given the higher melanin content in the epidermis. Although Q-switched lasers are widely considered to be the standard treatment for both epidermal and dermal pigmentary conditions, a very high risk of post-inflammatory hyperpigmentation (PIH) of up to 25% is seen in patients with skin of color. Recently, the novel picosecond laser with pulse durations operating at sub-nanosecond domains has been shown to be effective in tattoo removal and in the treatment of acne scars...
October 25, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/30321078/efficacy-of-fractional-carbon-dioxide-laser-versus-microneedling-in-the-treatment-of-striae-distensae
#8
Mona Soliman, Mohamed Mohsen Soliman, Amira El-Tawdy, Hoda Sayed Shorbagy
BACKGROUND: Fractional photothermolysis is creation of microscopic thermal zones of controlled depth, width and density. Microneedling is a simple treatment modality to reduce striae distensae. OBJECTIVE: Evaluate and compare the efficacy of fractional carbon dioxide laser and microneedling as a treatment of striae distensae. METHODS: Individuals with striae distensae received three split-body treatments at four-week intervals. The right side of the body was treated with fractional CO2 laser, while the other side with microneedling...
October 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/30321072/sterile-pustulosis-as-a-rare-side-effect-of-fractional-bipolar-radiofrequency-device-a-case-report
#9
Sandhya Deverapalli, Nellie Konnikov
Fractional bipolar radiofrequency technology is associated with minimal downtime and rare side effects and become an increasingly popular tool in aesthetic dermatology practices. There is limited damage to the epidermis, and side effects such as post-inflammatory hypo/hyperpigmentation are rare. Transient erythema, edema, crusting, and persistent inflammatory papules have been previously reported. We report a rare case of sterile follicular pustulosis following treatment with bipolar fractional radiofrequency (eTwo technology)...
October 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/30320904/long-pulsed-dye-laser-with-a-back-to-back-double-pulse-technique-and-compression-for-the-treatment-of-epidermal-pigmented-lesions
#10
Jessica G Labadie, Aleksandar L Krunic
BACKGROUND: In the recent past, long pulsed dye lasers (LPDL) have been investigated for the treatment of epidermal pigmented lesions (EPLs). Using a pigmented lesion compression headpiece, blood is pushed laterally out of the laser field focusing laser energy on melanin. Recent studies have demonstrated excellent responses using a single-pulse at the following settings: 9-12 J/cm2 , 1.5 milliseconds, 7-10 mm spot size with compression. However, the majority of these studies report patients requiring up to four treatments for lesion resolution...
October 15, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/30152538/efficacy-and-safety-of-picosecond-755-nm-alexandrite-laser-with-diffractive-lens-array-for-non-ablative-rejuvenation-in-chinese-skin
#11
Heidi Wat, Samantha Yee-Nam Shek, Chi Keung Yeung, Henry Hin-Lee Chan
BACKGROUND AND OBJECTIVES: The picosecond alexandrite laser with diffractive lens array (DLA) offers the dual advantages of a picosecond pulse duration and the fractionated delivery of laser energy. This study explores the efficacy and safety of the DLA for treatment of multiple aesthetic concerns associated with photoaging of the face including skin texture irregularities, dyspigmentation, enlarged pore size, rhytides, and skin laxity. METHODS: This prospective, evaluator-blinded trial enrolled Fitzpatrick skin type III-IV patients with mild to moderate signs of facial photoaging...
August 28, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/30118905/photodynamic-therapy-for-rosacea-in-chinese-patients
#12
Lili Fan, Rui Yin, Ting Lan, Michael R Hamblin
BACKGROUND: Rosacea is a common chronic cutaneous disorder which is characterized by flushing, erythema, papulopustules and telangiectasia. The pathogenesis of the disease is still unknown. A multifaceted approach is necessary to control the disease because of its tendency to relapse. New more effective treatment options are desirable to achieve a complete remission. Aminolevulinic acid-photodynamic therapy (ALA-PDT) is a well-established treatment for non-melanoma skin cancer and precancerous lesions...
August 14, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/30057662/patterns-of-over-the-counter-lightening-agent-use-among-patients-with-hyperpigmentation-disorders-a-united-states-based-cohort-study
#13
Dana S Saade, Mayra B C Maymone, Eric A Secemsky, Kevin F Kennedy, Neelam A Vashi
Background: Over-the-counter (OTC) lightening agents are commonly used to treat hyperpigmentation disorders. Objective: We sought to determine the characteristics, trends, and preferences of patients with hyperpigmentation disorders seeking OTC agents in the United States. Design: The study was a cross-sectional study of consecutive patients with a disorder of hyperpigmentation seen in a United States-based outpatient dermatology clinic. Multivariable logistic regression models were used to identify factors associated with the use of OTC lightening agents...
July 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29956440/the-effects-of-recombinant-human-epidermal-growth-factor-containing-ointment-on-wound-healing-and-post-inflammatory-hyperpigmentation-prevention-after-fractional-ablative-skin-resurfacing-a-split-face-randomized-controlled-study
#14
Thanya Techapichetvanich, Rungsima Wanitphakdeedecha, Thanawan Iamphonrat, Weeranut Phothong, Sasima Eimpunth, Inneke Jane Hidajat, Woraphong Manuskiatti
BACKGROUND: Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited. OBJECTIVES: To evaluate the effects of the topical EGF ointment on wound healing process and postinflammatory hyperpigmentation (PIH) prevention after fractional ablative laser resurfacing. MATERIALS AND METHODS: This is a randomized split-face study...
June 29, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29794637/treatment-of-facial-hypopigmented-scars-by-the-laser-hole-technique-using-a-nonfractional-carbon-dioxide-laser-in-asians
#15
Jin Sik Burm, Yung Ki Lee, Cho Jae Young
BACKGROUND: Facial hypopigmented scars are usually characterized by white color and a glossy surface. To correct the two problems simultaneously, the authors attempted to induce persistent postinflammatory hyperpigmentation for color and to build multiple pitted scars like facial skin pores for texture. This study describes a laser hole method using a traditional nonfractional carbon dioxide laser for treatment of facial hypopigmented scars and evaluates the clinical results. METHODS: Forty-three facial hypopigmented scars in 27 patients were treated, excluding protruding or thick scars...
August 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29785134/the-impact-of-acne-and-facial-post-inflammatory-hyperpigmentation-on-quality-of-life-and-self-esteem-of-newly-admitted-nigerian-undergraduates
#16
Adeolu Oladayo Akinboro, Ogochukwu Ifeanyi Ezejiofor, Fatai Olatunde Olanrewaju, Mufutau Muphy Oripelaye, Olatunde Peter Olabode, Olugbenga Edward Ayodele, Emmanuel Olaniyi Onayemi
Background: Acne and facial post-inflammatory hyperpigmentation are relatively common clinical conditions among adolescents and young adults, and inflict psychosocial injuries on sufferers. Objective: To document the psychosocial and self-esteem implications of acne and facial hyperpigmentation on newly admitted undergraduates. Materials and methods: A cross-sectional survey was conducted among 200 undergraduates. Demographics and clinical characteristics were obtained and acne was graded using the US Food and Drug Administration 5-category global system of acne classification...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29696940/assessment-of-a-topical-product-based-on-polysulfated-galactosaminoglycan-as-an-adjuvant-in-the-treatment-of-acute-stp-and-stasis-dermo-hypodermitis
#17
Angelo Santoliquido
BACKGROUND: Superficial thrombophlebitis (STP) is a relatively frequent pathology characterized by possible extension to the deep venous circulation, with notable local inflammatory reaction which is treated by subcutaneous administration of Fondaparinux. Stasis dermo-hypodermitis is characterized by cutaneous hyperpigmentation and eczema, treatment for which consists of the use of drugs targeting endothelial cells (mesoglycan, FFPM, sulodexide). In this study we evaluated the impact of local application of a mixture of semi-synthetic polysulfated galactosaminoglycans on the regression rate of STP and dermo-hypodermitis in patients treated with best medical therapy (BMT)...
August 2018: Minerva Medica
https://www.readbyqxmd.com/read/29608215/prospective-study-of-removing-solar-lentigines-in-asians-using-a-novel-dual-wavelength-and-dual-pulse-width-picosecond-laser
#18
Kei Negishi, Hirotaka Akita, Yukiko Matsunaga
OBJECTIVES: Quality-switched (QS) lasers are known to be an effective treatment for removing solar lentigines, however, high incidence of post-inflammatory hyperpigmentation (PIH) is a concern in darker skin types. The objective of this study was to evaluate the efficacy and safety of a dual-wavelength and dual-pulse width picosecond Nd:YAG laser for removing solar lentigines in Asians. METHODS: This was a prospective, IRB-approved study. Twenty cases with solar lentigines on the face were enrolled for treatment and evaluated at 1- and 3-month after the final treatment...
October 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29574803/preventive-effect-of-polynucleotide-on-post-thyroidectomy-scars-a-randomized-double-blinded-controlled-trial
#19
Ji Hee Kim, Jong Ju Jeong, Young In Lee, Won Jai Lee, Chorok Lee, Woong Youn Chung, Kee-Hyun Nam, Ju Hee Lee
BACKGROUND AND OBJECTIVE: Polynucleotide (PN) provides a structural scaffold to induce anti-inflammatory and enhanced wound healing properties, and this study aimed to assess the efficacy of PN administration in the prevention of post-operative scars after conventional open total thyroidectomy. STUDY DESIGN MATERIALS AND METHODS: Forty-two patients with thyroid carcinoma who underwent total thyroidectomy were randomly assigned to the study (PN administration) or control (normal saline) group...
March 25, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29518457/assessing-the-safety-of-superficial-chemical-peels-in-darker-skin-a-retrospective-study
#20
Shalini Vemula, Mayra B C Maymone, Eric A Secemsky, Raphael Widjajahakim, Nicole M Patzelt, Dana Saade, Neelam A Vashi
BACKGROUND: Chemical peels have shown efficacy in the treatment of acne, photoaging, and pigmentary dyschromias; however, studies evaluating side effects, particularly in patients with skin of color, are limited. OBJECTIVE: We sought to determine the frequency of side effects and complications associated with superficial chemical peels in patients with skin types III-VI. METHODS: A 5-year single center retrospective analysis was performed...
September 2018: Journal of the American Academy of Dermatology
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