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https://www.readbyqxmd.com/read/30114627/recipient-derived-il-22-alleviates-murine-acute-graft-versus-host-disease-in-association-with-reduced-activation-of-antigen-presenting-cells
#1
Bin Pan, Fan Xia, Yujing Wu, Fan Zhang, Zhenzhen Lu, Ruixue Fu, Longmei Shang, Lingling Li, Zengtian Sun, Lingyu Zeng, Kailin Xu
Acute graft-versus-host disease (aGVHD) remains a major challenging complication of patients receiving allogeneic hematopoietic cell transplantation (allo-HCT). CD4+ effector T cells and their related cytokines mediate pathogenesis of aGVHD, in which donor-T-cell derived interleukin-22 (IL-22) was recently indicated to play a role. The role of recipient-derived IL-22 in aGVHD remains to be elucidated. By applying IL-22 knock out (IL-22KO) mice as recipients of allotransplant, we found recipient derived IL-22 alleviated aGVHD and improved survival of allotransplant recipients...
August 13, 2018: Cytokine
https://www.readbyqxmd.com/read/30099732/a-hyperbaric-warm-perfusion-system-preserves-tissue-composites-ex-vivo-and-delays-the-onset-of-acute-rejection
#2
Charles Anton Fries, Carole Yasay Villamaria, Jerry Richard Spencer, Shari Lawson, Lin Wang, Thomas Raj, E George Wolf, Bijaya Kumar Parida, Vijay Saradhi Gorantla, Rory Frederick Rickard, Michael Robert Davis
BACKGROUND:  Ischemia-reperfusion injury (IRI) precipitates acute rejection of vascularized composite allografts (VCA). Hyperbaric preservation of tissues ex vivo, between harvest and revascularization, may reduce IRI and mitigate acute rejection of VCA. METHODS:  A porcine heterotopic musculocutaneous gracilis flap model was used. In phase 1, control autografts ( n  = 5) were infused with University of Wisconsin Solution (UWS) and stored at 4°C for 3 hours...
August 12, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/30091857/defining-the-optimal-duration-for-normothermic-regional-perfusion-in-the-kidney-donor-a-porcine-preclinical-study
#3
Thomas Kerforne, Geraldine Allain, Sebastien Giraud, Delphine Bon, Virginie Ameteau, Pierre Couturier, William Hebrard, Jerome Danion, Jean-Michel Goujon, Raphael Thuillier, Thierry Hauet, Benoit Barrou, Christophe Jayle
Kidneys from donation after circulatory death (DCD) are highly sensitive to ischemia-reperfusion injury and thus require careful reconditioning, such as Normothermic Regional Perfusion (NRP). However, the optimal NRP protocol remains to be characterized. NRP was modeled in a DCD porcine model (30min of cardiac arrest) for 2h, 4h or 6h compared to a control group (noNRP); kidneys were machine-preserved and allotransplanted. NRP appeared to permit recovery from warm ischemia, possibly due to increased expression of HIF1α-dependent survival pathway...
August 9, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/30056920/frequency-of-human-papilloma-virus-occurrence-among-pathological-changes-of-the-oral-cavity-in-kidney-allotransplant-recipients-undergoing-long-term-pharmacological-immunosuppressive-therapy
#4
D Szubińska-Lelonkiewicz, M Osiak, P Wychowański, M Siewert-Gutowska, P Fiedor
Recipients of allotransplants are more susceptible to viral infections, among which the human papilloma virus infection is an independent factor inducing precancerous lesions and cancers of both the anogenital and the cervicocephalic region. MATERIALS AND METHODS: The study included a group of 69 allogenic kidney transplantation recipients aged 20 to 70, who were treated with cyclosporine, azathioprine, and prednisone. The patients in whom the macroscopic examination of the oral mucosa revealed lesions were qualified for a biopsy...
July 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30053444/the-suppression-effect-of-dendritic-cells-maturation-by-adipose-derived-stem-cells-through-tgf-%C3%AE-1-related-pathway
#5
Yu-Chi Wang, Rong-Fu Chen, Gerald Brandacher, W P Andrew Lee, Yur-Ren Kuo
BACKGROUND: Our previous studies demonstrated that adipose-derived stem cells (ASCs) could modulate regulatory T cells (Treg) and prolong hind-limb allotransplant survival in vitro and in vivo. Dendritic cells (DCs) play a pivotal role in innate and adaptive immunity. The aim of this study is to investigate the underlying mechanism of ASCs in modulating DC maturation. MATERIALS AND METHODS: ASCs were isolated from rodent adipose tissue, DCs were derived from the bone marrow, and CD4+ T cells were purified from splenocytes...
July 24, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30021770/pre-existing-maternal-antibodies-cause-rapid-prenatal-rejection-of-allotransplants-in-the-mouse-model-of-in-utero-hematopoietic-cell-transplantation
#6
John S Riley, Lauren E McClain, John D Stratigis, Barbara E Coons, Haiying Li, Heather A Hartman, William H Peranteau
In utero hematopoietic cell transplantation (IUHCT) is a nonmyeloablative nonimmunosuppressive alternative to postnatal hematopoietic stem cell transplantation for the treatment of congenital hemoglobinopathies. Anti-HLA donor-specific Abs (DSA) are associated with a high incidence of graft rejection following postnatal hematopoietic stem cell transplantation. We determine if DSA present in the mother can similarly cause graft rejection in the fetus following IUHCT. Ten million C57BL/6 (B6, H2kb ) bone marrow cells were transplanted in utero into gestational day 14 BALB/c (H2kd ) fetuses...
July 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30013566/upregulation-of-heme-oxygenase-1-endues-immature-dendritic-cells-with-more-potent-and-durable-immunoregulatory-properties-and-promotes-engraftment-in-a-stringent-mouse-cardiac-allotransplant-model
#7
Yue Zhao, Yu Jia, Lu Wang, Song Chen, Xia Huang, Bingyang Xu, Guangyuan Zhao, Ying Xiang, Jun Yang, Gang Chen
Heme oxygenase-1 (HO-1) is critical for the ability of immature dendritic cells (imDCs) to suppress T-cell responses. Induction of high HO-1 expression may markedly improve the tolerogenic capacity of imDCs. Here, we generated bone marrow-derived DCs (BMDCs) from BALB/c mice with low doses of GM-CSF and IL-4. The adherent BMDCs were obtained as imDCs. Upregulation of HO-1 in imDCs (HO-1hi -imDCs) was achieved by cobalt protoporphyrin treatment. HO-1hi -imDCs proved to be more maturation-resistant than conventional imDCs, with an enhanced ability to inhibit allogeneic T-cell proliferation stimulated by anti-CD3/CD28 antibodies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29984829/impairment-of-bone-marrow-endothelial-progenitor-cells-in-acute-graft-versus-host-disease-patients-after-allotransplant
#8
Xie-Na Cao, Yuan Kong, Yang Song, Min-Min Shi, Hong-Yan Zhao, Qi Wen, Zhong-Shi Lyu, Cai-Wen Duan, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang
Graft-versus-host disease (GVHD) is a major complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT) that is frequently associated with bone marrow (BM) suppression, and clinical management is challenging. BM endothelial progenitor cells (EPCs) play crucial roles in the regulation of haematopoiesis and thrombopoiesis. However, little is known regarding the functional roles of BM EPCs in acute GVHD (aGVHD) patients. In the current prospective case-control study, reduced and dysfunctional BM EPCs, characterized by decreased migration and angiogenesis capacities and increased levels of reactive oxygen species (ROS) and apoptosis, were found in aGVHD patients compared with those without aGVHD...
July 9, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29945289/cell-based-therapies-in-vascularized-composite-allotransplantation
#9
Krishna S Vyas, Anita T Mohan, Shane D Morrison, Duy C Tran, Samir Mardini
BACKGROUND:  Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells with tolerogenic function. The ability of DCs to regulate alloantigen-specific T cell responses and to promote tolerance has aligned them ideally for a role in vascularized composite allotransplantation (VCA). In this study, we summarize the current evidence for DC therapies for tolerance induction to alleviate the requirement for chronic immunosuppression. METHOD:  A comprehensive and structured review of manuscripts published on VCA was performed using the MEDLINE and PubMed databases...
June 26, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29795418/favorable-immune-recovery-and-low-rate-of-gvhd-in-children-transplanted-with-partially-t-cell-depleted-pbsc-grafts
#10
Christian Martin Seitz, Matthias Eyrich, Johann Greil, Patrick Schlegel, Tobias Feuchtinger, Peter Bader, Martin Ebinger, Carl Philipp Schwarze, Paul Gerhardt Schlegel, Michael Schumm, Rupert Handgretinger, Peter Lang
Transplantation of peripheral blood stem cells (PBSC) from matched unrelated donors (MUD) is still associated with a significant risk for graft vs. host disease (GvHD), especially in pediatric patients receiving grafts from adult donors containing high amounts of T cells. Here, we present long-term follow-up results on 25 pediatric patients, (acute leukemia n = 15, NHL n = 3, CML n = 3, MDS n = 5), transplanted with CD34 or CD133 positively selected PBSC from MUDs supplemented with an add-back of 1 × 107 /kg body weight (kgBW) unselected T cells resulting in a median T-cell depletion (TCD) of 1...
May 24, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29728701/ibrutinib-for-bridging-to-allogeneic-hematopoietic-cell-transplantation-in-patients-with-chronic-lymphocytic-leukemia-or-mantle-cell-lymphoma-a-study-by-the-ebmt-chronic-malignancies-and-lymphoma-working-parties
#11
Peter Dreger, Mauricette Michallet, Paul Bosman, Sascha Dietrich, Mohamad Sobh, Ariane Boumendil, Arnon Nagler, Christof Scheid, Jan Cornelissen, Dietger Niederwieser, Lutz Müller, Elizabeth Vandenberghe, Ilaria Scortechini, Helene Schoemans, Niels S Andersen, Jürgen Finke, Domenico Russo, Per Ljungman, Jakob Passweg, Michel van Gelder, Nadira Durakovic, Helene Labussiere-Wallet, Tobias Berg, Gerald Wulf, Wolfgang Bethge, Donald Bunjes, Stefan Stilgenbauer, Maria Elisa Canepari, Michel Schaap, Christopher P Fox, Nicolaus Kröger, Silvia Montoto, Johannes Schetelig
The aim of this retrospective study was to investigate the safety and efficacy of allogeneic hematopoietic cell transplantation (alloHCT) in patients pre-treated with ibrutinib. Eligible were patients aged >18 years allotransplanted for chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL) after prior exposure to ibrutinib who were registered with the EBMT registry. Seventy patients (CLL 48, MCL 22) were included. At the time of alloHCT, 73% of the patients were ibrutinib responsive. All patients except one engrafted, and acute GVHD grade 2-4 (3-4) was observed in 49% (12%) of 68 evaluable patients...
May 4, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29726063/interspecies-incompatibilities-limit-the-immunomodulatory-effect-of-human-mesenchymal-stromal-cells-in-the-rat
#12
Paul Lohan, Oliver Treacy, Maurice Morcos, Ellen Donohoe, Yvonne O'donoghue, Aideen E Ryan, Stephen J Elliman, Thomas Ritter, Matthew D Griffin
Mesenchymal stem/stromal cells (MSC) are an immunomodulatory cell population which are under preclinical and clinical investigation for a number of inflammatory conditions including transplantation. In this study, a well-established rat corneal transplantation model was used to test the ability of human MSC to prolong corneal allograft rejection-free survival using a pre-transplant intravenous infusion protocol previously shown to be efficacious with allogeneic rat MSC. Surprisingly, pre-transplant administration of human MSC had no effect on corneal allograft survival...
May 3, 2018: Stem Cells
https://www.readbyqxmd.com/read/29682375/myeloid-sarcoma-after-allogenic-stem-cell-transplantation-for-acute-myeloid-leukemia-successful-consolidation-treatment-approaches-in-two-patients
#13
Silje Johansen, Hilde Kollsete Gjelberg, Aymen Bushra Ahmed, Øystein Bruserud, Håkon Reikvam
Myeloid sarcoma is an extramedullary (EM) manifestation (i.e., manifestation outside the bone marrow) of acute myeloid leukemia (AML); it is assumed to be relatively uncommon and can be the only manifestation of leukemia relapse after allogenic stem cell transplantation (allo-SCT). An EM sarcoma can manifest in any part of the body, although preferentially manifesting in immunological sanctuary sites as a single or multiple tumors. The development of myeloid sarcoma after allo-SCT is associated with certain cytogenetic abnormalities, developing of graft versus host disease (GVHD), and treatment with donor lymphocytes infusion (DLI)...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29576502/the-healthy-donor-profile-of-immunoregulatory-soluble-mediators-is-altered-by-stem-cell-mobilization-and-apheresis
#14
Guro Kristin Melve, Elisabeth Ersvaer, Kristin Paulsen Rye, Aymen Bushra Ahmed, Einar K Kristoffersen, Tor Hervig, Håkon Reikvam, Kimberley Joanne Hatfield, Øystein Bruserud
BACKGROUND: Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and thereafter harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. METHODS: Plasma levels of 38 soluble mediators (cytokines, soluble adhesion molecules, proteases, protease inhibitors) were analyzed in samples derived from healthy stem cell donors before G-CSF treatment and after 4 days, both immediately before and after leukapheresis...
May 2018: Cytotherapy
https://www.readbyqxmd.com/read/29575114/american-council-on-ecp-ace-why-now
#15
Richard Edelson, Yanyun Wu, Jennifer Schneiderman
Stimulated by the scientific progress in deciphering the principal elements contributing to the clinical efficacy of extracorporeal photochemotherapy (ECP), the American Council on ECP (ACE) was formed, under the auspices of the American Society for Apheresis (ASFA), to develop a field-guiding Consensus Report. ACE is composed of thirty nationally recognized ECP experts, clinically spanning cancer, transplantation, and autoimmunity and scientifically bridging immunology, bioengineering, and hematology. The two-day meeting took place in Manhattan, April 13-14, 2017, and unanimous consensus on nine pivotal points is herein reported...
March 25, 2018: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29561493/lacrimal-apparatus-procurement-in-face-transplantation
#16
Asif Hasan, Colin Maciver, Gaoussou Toure, Jean-Paul Meningaud
The aesthetic outcome of a well-planned and executed vascularized composite tissue face allotransplant is unquestionable; however, complete functional restoration is necessary. The authors studied the possibility of restoring tear duct function in face transplant recipients. They also examined the technical specifics and feasibility of incorporating a lacrimal drainage apparatus into facial allografting. The authors performed a standardized face vascularized composite allograft on 4 hemi-faces (2 fresh cadavers)...
June 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29536029/de-novo-circulating-antidonor-s-cell-antibodies-during-induced-acute-rejection-of-allogeneic-myofibers-in-myogenic-cell-transplantation-a-study-in-nonhuman-primates
#17
Daniel Skuk, Jacques P Tremblay
Background: Transplantation of myogenic cells has potential applications in the treatment of muscle pathologies. Excluding purely autologous cell transplantation, graft viability depends on an adequate control of acute rejection (AR). To contribute in understanding AR in this context, we analyzed whether de novo circulating antibodies against donor's cells are detected during induced AR of graft-derived myofibers in nonhuman primates. Methods: We allotransplanted satellite cell-derived myoblasts in macaques immunosuppressed with tacrolimus...
December 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29513361/a-pilot-study-of-single-nucleotide-polymorphisms-in-the-interleukin-6-receptor-and-their-effects-on-pre-and-post-transplant-serum-mediator-level-and-outcome-after-allogeneic-stem-cell-transplantation
#18
T H A Tvedt, R Hovland, G Tsykunova, A B Ahmed, T Gedde-Dahl, Ø Bruserud
Interleukin (IL)-6 is an important regulator of immunity and inflammation in many diseases. Single nucleotide polymorphisms (SNPs) in the IL-6 gene influence outcome after allogeneic stem cell transplantation (ASCT), but the possible importance of SNPs in the IL-6 receptor has not been examined. We therefore investigated whether SNPs in the IL-6R gene influenced biochemical characteristics and clinical outcomes after ASCT. We examined the IL-6 promoter variant rs1800975 and the IL-6R SNPs rs4453032, rs2228145, rs4129267, rs4845374, rs4329505, rs4845617, rs12083537, rs4845618, rs6698040 and rs4379670 in a 101 population-based cohort of allotransplant recipients and their family donors...
July 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29504151/bone-vascularized-composite-allotransplantation-model-in-swine-tibial-defect-evaluation-of-surgical-angiogenesis-and-transplant-viability
#19
Dimitra Kotsougiani, Caroline A Hundepool, Liselotte F Bulstra, Patricia F Friedrich, Alexander Y Shin, Allen T Bishop
INTRODUCTION: In prior small animal studies, we maintained vascularized bone allotransplant viability without long-term immunotherapy. Instead, an autogenous neoangiogenic circulation is created from implanted vessels, sufficient to maintain bone viability with only 2 weeks immunosupression. Blood flow is maintained despite rejection of the allogeneic vascular pedicle thereafter. We have previously described a large animal (swine) pre-clinical model, reconstructing tibial defects with vascularized tibial allotransplants...
March 5, 2018: Microsurgery
https://www.readbyqxmd.com/read/29478054/bringing-home-the-bacon-update-on-the-state-of-kidney-xenotransplantation
#20
David K C Cooper, H Iwase, L Wang, T Yamamoto, Qi Li, J Li, H Zhou, H Hara
BACKGROUND: There is a continuing critical shortage of organs from deceased human donors for transplantation, particularly for patients awaiting kidney transplantation. Efforts are being made to resolve the donor kidney shortage by the transplantation of kidneys from genetically-engineered pigs. SUMMARY: This review outlines the pathobiological barriers to pig organ xenotransplantation in primates, which include (i) antibody-dependent complement-mediated rejection, (ii) a T cell-mediated elicited antibody and cellular response, (iii) coagulation dysregulation between pigs and primates, and (iv) a persistent inflammatory response...
2018: Blood Purification
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