Hongjuan Wang, Yushan Tian, Yaning Fu, Shuhao Ma, Xiaoxiao Xu, Wenming Wang, Fengjun Lu, Xianmei Li, Pengxia Feng, Shulei Han, Huan Chen, Hongwei Hou, Qingyuan Hu, Chuan Liu
BACKGROUND: Researches have shown that chronic inhalation of cigarette smoke (CS) disrupts male reproductive system, but it is unclear about the mechanisms behind reproductive damages by tobacco toxicants in male rats. This study was designed to explore the effects of heated tobacco products (HTP) aerosols and CS exposure on the testicular health of rats. MATERIALS AND METHODS: Experiments were performed on male SD rats exposed to filtered air, HTP aerosols at 10 μg/L, 23 μg/L, and 50 μg/L nicotine-equivalent contents, and also CS at 23 μg/L nicotine-equivalent content for 90 days in five exposure groups (coded as sham, HTP_10, HTP_23, HTP_50 and Cig_23)...
October 2023: Toxicology Research