keyword
https://read.qxmd.com/read/38504011/vagus-nerve-stimulation-as-a-promising-neuroprotection-for-ischemic-stroke-via-%C3%AE-7nachr-dependent-inactivation-of-microglial-nlrp3-inflammasome
#1
JOURNAL ARTICLE
Xiao-Mei Xia, Yu Duan, Yue-Ping Wang, Rui-Xue Han, Yin-Feng Dong, Si-Yuan Jiang, Yu Zheng, Chen Qiao, Lei Cao, Xiao Lu, Ming Lu
Ischemic stroke is a major cause of disability and death worldwide, and its management requires urgent attention. Previous studies have shown that vagus nerve stimulation (VNS) exerts neuroprotection in ischemic stroke by inhibiting neuroinflammation and apoptosis. In this study, we evaluated the timing for VNS intervention in ischemic stroke, and the underlying mechanisms  of VNS-induced neuroprotection. Mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 60 min. The left vagus nerve at cervical level was exposed and attached to an electrode connected to a low-frequency electrical stimulator...
March 19, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38018885/effects-of-combustible-cigarettes-and-electronic-nicotine-delivery-systems-on-the-development-and-progression-of-chronic-lung-inflammation-in-mice
#2
JOURNAL ARTICLE
Nikolina Kastratovic, Vladimir Markovic, Carl Randall Harrell, Aleksandar Arsenijevic, Milica Dimitrijevic Stojanovic, Valentin Djonov, Vladislav Volarevic
INTRODUCTION: Although detrimental effects of combustible cigarettes (CCs) on the progression of lung inflammatory diseases are well known, changes in electronic nicotine delivery systems (ENDS)-exposed lung-infiltrated immune cells are still unrevealed. METHODS: The analysis of blood gas parameters, descriptive and quantitative histology of lung tissues, determination of serum cytokines, intracellular staining and flow cytometry analysis of lung-infiltrated immune cells were used to determine the differences in the extent of lung injury and inflammation between mice from experimental (CC and ENDS-exposed animals) and control group (Air-exposed mice)...
November 29, 2023: Nicotine & Tobacco Research
https://read.qxmd.com/read/38018308/pyroptosis-is-involved-in-maternal-nicotine-exposure-induced-metabolic-associated-fatty-liver-disease-progression-in-offspring-mice
#3
JOURNAL ARTICLE
Yu-Qing Su, Yan Lin, Shu-Jing Huang, Yan-Ting Lin, Jing Ran, Fang-Fang Yan, Xian-Lan Liu, Long-Cheng Hong, Mei Huang, Huan-Zhong Su, Xiao-Dong Zhang, Jian-Hong You, Yi-Ming Su
We have investigated whether inflammasomes and pyroptosis are activated in maternal nicotine exposure (MNE) offspring mice and whether they are involved in MNE-promoted metabolic associated fatty liver disease (MAFLD) in adult offspring. We injected pregnant mice subcutaneously with saline vehicle or nicotine twice a day on gestational days 11-21. Offspring mice from both groups were fed with a normal diet (ND) or a high-fat diet (HFD) for 6 months at postnatal day 21 to develop the MAFLD model. Serum biochemical indices were analyzed, and liver histology was performed...
November 28, 2023: Molecular Reproduction and Development
https://read.qxmd.com/read/37915495/testicular-tissue-response-following-a-90-day-subchronic-exposure-to-htp-aerosols-and-cigarette-smoke-in-rats
#4
JOURNAL ARTICLE
Hongjuan Wang, Yushan Tian, Yaning Fu, Shuhao Ma, Xiaoxiao Xu, Wenming Wang, Fengjun Lu, Xianmei Li, Pengxia Feng, Shulei Han, Huan Chen, Hongwei Hou, Qingyuan Hu, Chuan Liu
BACKGROUND: Researches have shown that chronic inhalation of cigarette smoke (CS) disrupts male reproductive system, but it is unclear about the mechanisms behind reproductive damages by tobacco toxicants in male rats. This study was designed to explore the effects of heated tobacco products (HTP) aerosols and CS exposure on the testicular health of rats. MATERIALS AND METHODS: Experiments were performed on male SD rats exposed to filtered air, HTP aerosols at 10 μg/L, 23 μg/L, and 50 μg/L nicotine-equivalent contents, and also CS at 23 μg/L nicotine-equivalent content for 90 days in five exposure groups (coded as sham, HTP_10, HTP_23, HTP_50 and Cig_23)...
October 2023: Toxicology Research
https://read.qxmd.com/read/37720875/cigarette-smoking-contributes-to-th1-th2-cell-dysfunction-via-the-cytokine-milieu-in-chronic-obstructive-pulmonary-disease
#5
JOURNAL ARTICLE
Gang Chen, Qing Mu, Zhao-Ji Meng
BACKGROUND: Dysregulation and pyroptosis of T-helper (Th) cells and inflammatory cytokines have been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the immune response mechanisms as a consequence of tobacco smoke exposure are not fully understood. We hypothesized that cigarette smoke-induced inflammation could be modulated through the cytokine milieu and T-cell nicotinic acetylcholine receptors (nAChRs). METHODS: The proportions of peripheral blood Th1 and Th2 cells from patients with COPD, smokers without airway obstruction and healthy nonsmokers were analyzed using flow cytometry...
2023: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/37604293/nicotinic-acid-attenuates-experimental-non-alcoholic-steatohepatitis-by-inhibiting-the-nlrp3-inflammasome-pyroptosis-pathway
#6
JOURNAL ARTICLE
Irina Cardoso-Lezama, Miguel Á Fuentes-Figueroa, Erika Ramos-Tovar, Linda V Márquez-Quiroga, Arturo Ortiz-Fernández, Eduardo E Vargas-Pozada, Jaime Arellanes-Robledo, Víctor Tsutsumi, Pablo Muriel
Non-alcoholic steatohepatitis (NASH) is a global public health concern that may progress into fibrosis, cirrhosis, and liver cancer, with limited curative treatment options. While the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is closely linked to NASH progression, nicotinic acid (NA), a vitamin used for the treatment of dyslipidemia, is an emerging pharmaceutical treatment for hepatic steatosis and fibrosis. Here, we investigated pharmacological effects of NA on experimental NASH and whether NLRP3 inflammasome/pyroptosis inhibition is an associated mechanism of action...
October 2023: Biochemical Pharmacology
https://read.qxmd.com/read/37562290/sirt1-parp-1-nlrp3-cascade-as-a-potential-target-for-niacin-neuroprotective-effect-in-lipopolysaccharide-induced-depressive-like-behavior-in-mice
#7
JOURNAL ARTICLE
Nora O Abdel Rasheed, Nesma A Shiha, Sarah S Mohamed, Weam W Ibrahim
UNLABELLED: Depression is a serious mood disorder characterized by monoamines deficiency, oxidative stress, neuroinflammation, and cell death. Niacin (vitamin B3 or nicotinic acid, NA), a chief mediator of neuronal development and survival in the central nervous system, exerts neuroprotective effects in several experimental models. AIMS: This study aimed to investigate the effect of NA in lipopolysaccharide (LPS) mouse model of depression exploring its ability to regulate sirtuin1/poly (ADP-ribose) polymerase-1 (PARP-1)/nod-likereceptor protein 3 (NLRP3) signaling...
August 8, 2023: International Immunopharmacology
https://read.qxmd.com/read/37478567/nicotine-induces-macrophage-pyroptosis-via-linc01272-mir-515-klf6-axis
#8
JOURNAL ARTICLE
Lianjie Hou, Qin He, Yu Wang, Xixi Feng, Yali Mi, Shuang Li, Jie Feng Deng, Guojun Zhao
Nicotine contributes to the causation of atherosclerosis, which the prominent cellular components are macrophages. Long non-coding RNAs (lncRNAs) play an important role in regulating cell functions such as cell proliferation, differentiation and programmed death. However, the function and mechanism of lncRNAs in nicotine-induced macrophage pyroptosis has not been reported. We screened the deferentially expressed lncRNAs of human carotid artery plaque (GSE97210) and verified them in nicotine-induced pyroptosis of macrophages...
September 15, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/37284455/nicotine-exacerbates-atherosclerosis-and-plaque-instability-via-nlrp3-inflammasome-activation-in-vascular-smooth-muscle-cells
#9
JOURNAL ARTICLE
Junqing An, Liu Ouyang, Changjiang Yu, Sean Michael Carr, Tharmarajan Ramprasath, Zhixue Liu, Ping Song, Ming-Hui Zou, Ye Ding
Rationale: Nicotine has been reported to be a strong risk factor for atherosclerosis. However, the underlying mechanism by which nicotine controls atherosclerotic plaque stability remain largely unknown. Objective: The aim of this study was to evaluate the impact of lysosomal dysfunction mediated NLRP3 inflammasome activation in vascular smooth muscle cell (VSMC) on atherosclerotic plaque formation and stability in advanced atherosclerosis at the brachiocephalic arteries (BA). Methods and Results: Features of atherosclerotic plaque stability and the markers for NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome were monitored in the BA from nicotine or vehicle-treated apolipoprotein E deficient ( Apoe-/- ) mice fed with Western-type diet (WD)...
2023: Theranostics
https://read.qxmd.com/read/37052522/pulmonary-immune-response-regulation-genotoxicity-and-metabolic-reprogramming-by-menthol-and-tobacco-flavored-e-cigarette-exposures-in-mice
#10
JOURNAL ARTICLE
Thivanka Muthumalage, Irfan Rahman
Menthol and tobacco flavors are available for almost all tobacco products, including electronic cigarettes (e-cigs). These flavors are a mixture of chemicals with overlapping constituents. There are no comparative toxicity studies of these flavors produced by different manufacturers. We hypothesized that acute exposure to menthol and tobacco-flavored e-cig aerosols induces inflammatory, genotoxicity, and metabolic responses in mouse lungs. We compared two brands, A and B, of e-cig flavors (PG/VG, menthol, and tobacco) with and without nicotine for their inflammatory response, genotoxic markers, and altered genes and proteins in the context of metabolism by exposing mouse strains, C57BL/6J (Th1-mediated) and BALB/cJ (Th2-mediated)...
May 31, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36740464/sacral-nerve-stimulation-alleviates-intestinal-inflammation-through-regulating-the-autophagy-of-macrophages-and-activating-the-inflammasome-mediated-by-a-cholinergic-antiinflammatory-pathway-in-colitis-rats
#11
JOURNAL ARTICLE
Shuhui Zhang, Can Zhang, Hui Yan, Lijuan Yang, Ning Shi, Chengxia Liu, Yan Chen
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by chronic progressive intestinal inflammation. Sacral nerve stimulation (SNS) ameliorates colon inflammation caused by IBD. The aim of this study was to investigate the antiinflammatory benefits of SNS in colitis rats and explore the roles of the cholinergic antiinflammatory pathway, macrophage autophagy, and nucleotide oligomerization domain-like receptor thermal protein domain associated protein 3 (NLRP3) inflammatory bodies...
February 3, 2023: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/36105198/negative-regulation-of-atp-induced-inflammasome-activation-and-cytokine-secretion-by-acute-phase-proteins-a-mini-review
#12
REVIEW
Katrin Richter, Anca-Laura Amati, Winfried Padberg, Veronika Grau
The expression of the acute-phase reactants C-reactive protein (CRP), α1-antitrypsin (AAT), and secretory leukocyte protease inhibitor (SLPI), is induced in response to inflammation by pro-inflammatory mediators, including interleukin-1β. It is conceivable that acute-phase proteins exert protective functions, when the integrity of an organism is challenged by pathogens or trauma, which result in uncontrolled release of endogenous damage-associated molecular patterns like Toll-like receptor agonists and ATP...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35565726/procyanidin-b2-attenuates-nicotine-induced-hepatocyte-pyroptosis-through-a-ppar%C3%AE-dependent-mechanism
#13
JOURNAL ARTICLE
Jia Liu, Qinyu Yao, Xinya Xie, Qi Cui, Tingting Jiang, Ziwei Zhao, Xiong Du, Baochang Lai, Lei Xiao, Nanping Wang
Procyanidin B2 (PCB2), a natural flavonoid, has been demonstrated to exert anti-oxidation and anti-inflammatory effects on hepatic diseases. Increasing evidence shows the hepatoxicity of nicotine. However, whether PCB2 protects against nicotine-induced hepatoxicity and the underlying mechanisms remains uncharacterized. Here, we reported that nicotine promoted hepatocyte pyroptosis, as evidenced by the elevation of propidium iodide (PI)-positive cells, the activation of Caspase-1 and gasdermin D (GSDMD), the enhanced expression of NOD-like receptor containing pyrin domain 3 (NLRP3) and the increased release of lactate dehydrogenase (LDH), interleukin (IL)-1β and IL-18...
April 22, 2022: Nutrients
https://read.qxmd.com/read/35136042/vagus-nerve-stimulation-alleviated-cerebral-ischemia-and-reperfusion-injury-in-rats-by-inhibiting-pyroptosis-via-%C3%AE-7-nicotinic-acetylcholine-receptor
#14
JOURNAL ARTICLE
Hao Tang, Jiani Li, Qinxiang Zhou, Sheng Li, Chenchen Xie, Lingchuan Niu, Jingxi Ma, Changqing Li
Cumulative evidence suggests that pyroptosis, a new sort of programmed cell death, is closely related to cerebral ischemia/reperfusion (I/R) injury. Our previous studies have testified that vagus nerve stimulation (VNS) was involved in many different neuroprotective and neuroplasticity pathways via α7 nicotinic acetylcholine receptor (α7nAchR), a vital node of the cholinergic anti-inflammatory pathway during cerebral I/R injury. We aimed to determine the neuroprotective effects of VNS through α7nAchR-mediated inhibition of pyroptosis...
February 8, 2022: Cell Death Discovery
https://read.qxmd.com/read/35131329/the-role-of-%C3%AE-5-nicotinic-acetylcholine-receptor-nlrp3-signaling-pathway-in-lung-adenocarcinoma-cell-proliferation-and-migration
#15
JOURNAL ARTICLE
Ying Jia, Qian Zhang, Zhiyuan Liu, Pan Pan, Yanfei Jia, Ping Zhu, Yang Jiao, Guiyu Kang, Xiaoli Ma
α5-nicotinic acetylcholine receptor (α5-nAChR) is involved in tobacco smoking-induced lung carcinogenesis. Increasing evidence has highlighted the importance of inflammation in lung cancer and a strong relationship between smoking and the NLR family pyrin domain containing protein 3 (NLRP3) inflammasome. However, it is unclear whether an inflammation-related effect of α5-nAChR contributes to cigarette smoking-related lung cancer. Here, we identified a functional link between α5-nAChR and NLRP3 inflammasome activation in lung adenocarcinoma (LUAD)...
February 4, 2022: Toxicology
https://read.qxmd.com/read/35059736/nicotine-promotes-chronic-obstructive-pulmonary-disease-via-inducing-pyroptosis-activation-in-bronchial-epithelial-cells
#16
JOURNAL ARTICLE
Rubing Mo, Jun Zhang, Yongxing Chen, Yipeng Ding
Nicotine is one of the primary components in cigarettes, which is responsible for addiction. Numerous studies have investigated the effects of nicotine on pulmonary disease. The health of epithelial cells is important in the development of chronic obstructive pulmonary disease (COPD). Accumulating evidence has suggested that epithelial cell death may initiate or contribute to the progression of a number of lung diseases via airway remodeling. Pyroptosis is a unique form of inflammatory cell death mediated by the activation of caspase‑1 and the NOD‑like receptor protein‑3 (NLRP3) inflammasome...
March 2022: Molecular Medicine Reports
https://read.qxmd.com/read/34988776/activation-of-%C3%AE-7-nicotinic-acetylcholine-receptor-attenuates-cardiac-inflammation-through-nlrp3-caspase-1-il-18-pathway
#17
JOURNAL ARTICLE
Zijing Guo, Bin Tan, Junjie Wang, Weijun Tang, Linguo Pei, Yisi Chen, Jun Zhang
Activation of α-7 nicotinic acetylcholine receptor (α7nAChR) receptor might induce cardiac inflammation, cardiac remodeling, and dysfunction. In this regard, this study aims to clarify the role and mechanism of α7nAChR in the process of cardiac inflammation and damage. Normal male C57BL/6J and NLRP3-knockout mice were used to evaluate the effect of PHA-543613, a selective agonist of α7nAChR, on cardiac inflammation and possible involvement of NLRP3/Caspase-1/IL-18 using western blotting and ELISA. Activation of α7nAChR using PHA-543613 (NE), at the doses of 0...
January 6, 2022: Biochemical Genetics
https://read.qxmd.com/read/34941874/activation-of-the-alpha-7-nicotinic-acetylcholine-receptor-mitigates-osteoarthritis-progression-by-inhibiting-nf-%C3%AE%C2%BAb-nlrp3-inflammasome-activation-and-enhancing-autophagy
#18
JOURNAL ARTICLE
Xianjie Zhu, Shiyou Dai, Baohua Xia, Jianbao Gong, Bingzheng Ma
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage degradation. Alpha 7 nicotinic acetylcholine receptor (α7nAChR) is associated with inflammatory and metabolic responses in OA. However, the mechanisms underlying the pathological process of OA remain unclear. The aim of the present study was to examine the role and mechanisms of α7nAChR-mediated autophagy and anti-inflammatory response in chondroprotection. Monosodium iodoacetate (MIA)-induced Wistar rat OA model was used to assess the in vivo effects of the ɑ7nAChR agonist (PNU-282987)...
2021: PloS One
https://read.qxmd.com/read/34490270/%C3%AE-1-nachr-mediated-signaling-through-lipid-raft-is-required-for-nicotine-induced-nlrp3-inflammasome-activation-and-nicotine-accelerated-atherosclerosis
#19
JOURNAL ARTICLE
Fengqi Duan, Cheng Zeng, Sijun Liu, Jianfeng Gong, Jia Hu, Hongyu Li, Hongmei Tan
Background: Nicotine exerts direct effects on multiple cell types in the cardiovascular system by associating with its high-affinity nicotinic acetylcholine receptors (nAchRs). Lipid raft is a membrane microdomain that recruits various receptors and signaling molecules for coordinating cellular immune response and many others signaling processes. Here, we aim to identify the essential role of lipid raft in mediating nicotine-triggered inflammatory and nicotine-accelerated atherosclerosis, and to figure out the specific receptor of nicotine-induced Nod-like receptor protein 3 (NLRP3) inflammasome activation in macrophage...
2021: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/33626512/nicotine-exacerbates-atherosclerosis-through-a-macrophage-mediated-endothelial-injury-pathway
#20
JOURNAL ARTICLE
ChengYu Mao, DongJiu Li, En Zhou, JunFeng Zhang, ChangQian Wang, Chao Xue
Evidence suggests that nicotine intake promotes atherosclerosis. We enrolled 100 patients with coronary heart disease (CHD) and found that plaque burden, TXNIP expression, and inflammatory chemokine levels were higher in smokers than non-smokers. Additionally, patients with higher TXNIP expression in peripheral blood mononuclear cells (PBMCs) had a higher Gensini Scores and higher plasma IL-1β and IL-18 levels. Treating bone marrow-derived macrophages (BMDMs) with nicotine in vitro led to enhanced lipid phagocytosis, chemotaxis, and increased production of reactive oxygen species (ROS), which activated TXNIP/NLRP3 inflammasome signaling and promoted pyroptosis, as evidenced by caspase-1 cleavage and increased production of IL-1β, IL-18, and gasdermin D...
February 24, 2021: Aging
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