keyword
MENU ▼
Read by QxMD icon Read
search

microRNA-223 and inflammation

keyword
https://www.readbyqxmd.com/read/30515094/paeonol-attenuated-inflammatory-response-of-endothelial-cells-via-stimulating-monocytes-derived-exosomal-microrna-223
#1
Yarong Liu, Chao Li, Hongfei Wu, Xianmei Xie, Ying Sun, Min Dai
Introduction: Paeonol, an active compound isolated from the radix of Cortex Moutan , has been shown to have anti-atherosclerosis effects by regulating blood cells' function and protecting vascular cells injury. Besides, emerging evidences has proven that exosomes might play a pivotal role in intercellular communication by transmiting proteins and microRNAs from cell to cell. However, the relationship between monocytes-derived exosomal microRNA-223 and vascular inflammation injury along with paeonol' effects are still not clear...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30368846/inflammation-induced-overexpression-of-microrna-223-3p-regulates-odontoblastic-differentiation-of-human-dental-pulp-stem-cells-by-targeting-smad3
#2
X Huang, F Liu, J Hou, K Chen
AIM: To profile miRNA expression between inflamed and healthy human dental pulp tissues and to investigate how the up-regulation of miR-223-3p in the inflamed pulp tissue regulates odontoblast differentiation and regeneration. METHODOLOGY: Microarray analysis was used to identify differences in miRNA expression patterns between healthy and inflamed pulp tissue. The results were validated using quantitative real-time PCR. To determine the effect of miR-223-3p on odontoblast differentiation, miR-223-3p was overexpressed in human dental pulp stem cells (DPSCs), which were cultured in mineralizing induction medium (to induce odontoblast differentiation)...
October 28, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/30171089/targeting-mir-223-in-neutrophils-enhances-the-clearance-of-staphylococcus-aureus-in-infected-wounds
#3
Maiko de Kerckhove, Katsuya Tanaka, Takahiro Umehara, Momoko Okamoto, Sotaro Kanematsu, Hiroko Hayashi, Hiroki Yano, Soushi Nishiura, Shiho Tooyama, Yutaka Matsubayashi, Toshimitsu Komatsu, Seongjoon Park, Yuka Okada, Rina Takahashi, Yayoi Kawano, Takehisa Hanawa, Keisuke Iwasaki, Tadashige Nozaki, Hidetaka Torigoe, Kazuya Ikematsu, Yutaka Suzuki, Katsumi Tanaka, Paul Martin, Isao Shimokawa, Ryoichi Mori
Argonaute 2 bound mature microRNA (Ago2-miRNA) complexes are key regulators of the wound inflammatory response and function in the translational processing of target mRNAs. In this study, we identified four wound inflammation-related Ago2-miRNAs ( miR-139-5p , miR-142-3p , miR-142-5p , and miR-223 ) and show that miR-223 is critical for infection control. miR-223 Y /- mice exhibited delayed sterile healing with prolonged neutrophil activation and interleukin-6 expression, and markedly improved repair of Staphylococcus aureus -infected wounds...
October 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/30116492/analysis-of-plasma-micrornas-as-predictors-and-biomarkers-of-aging-and-frailty-in-humans
#4
Iryna Rusanova, María E Diaz-Casado, Marisol Fernández-Ortiz, Paula Aranda-Martínez, Ana Guerra-Librero, Francisco J García-García, Germaine Escames, Leocadio Mañas, Darío Acuña-Castroviejo
Although circulating microRNAs (miRNAs) can modulate gene expression and affect immune system response, little is known about their participation in age-associated frailty syndrome and sarcopenia. The aim of this study was to determine miRNAs as possible biomarkers of age and frailty and their correlation with oxidative and inflammatory state in human blood. Three inflammation-related miRNAs (miR-21, miR-146a, and miR-223) and one miRNA related with the control of melatonin synthesis (miR-483) were analyzed...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30076847/immunomodulatory-tetracyclines-ameliorate-dnbs-colitis-impact-on-microrna-expression-and-microbiota-composition
#5
J Garrido-Mesa, F Algieri, A Rodríguez-Nogales, T Vezza, M P Utrilla, F Garcia, N Chueca, M E Rodríguez-Cabezas, N Garrido-Mesa, J Gálvez
OBJECTIVE: The use of immunomodulatory antibiotics to simultaneously target different factors involved in intestinal inflammatory conditions is an interesting but understudied pharmacological strategy. A great therapeutic potential has been obtained with minocycline and doxycycline in experimental colitis. Therefore, understanding the contribution of the different activities of immunomodulatory tetracyclines is crucial for the improvement and translation of their use into clinic. DESIGN: A comparative pharmacological study including tetracyclines and other antibiotic or immunomodulatory drugs was performed in 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice...
September 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/30046303/the-role-of-autophagy-and-related-micrornas-in-inflammatory-bowel-disease
#6
REVIEW
Shiyuan Wang, Yan Huang, Cili Zhou, Huangan Wu, Jimeng Zhao, Luyi Wu, Min Zhao, Fang Zhang, Huirong Liu
Accumulating evidence demonstrates that microRNA- (miR-) mediated posttranscriptional regulation plays an important role in autophagy in inflammatory bowel disease (IBD), a disease that is difficult to manage clinically because of the associated chronic recurrent nonspecific inflammation. Research indicates that microRNAs regulate autophagy via different pathways, playing an important role in the IBD process and providing a new perspective for IBD research. Related studies have shown that miR-142-3p, miR-320, miR-192, and miR-122 target NOD2 , an IBD-relevant autophagy gene, to modulate autophagy in IBD...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29969525/microrna-mir-223-as-regulator-of-innate-immunity
#7
REVIEW
Xiaoyi Yuan, Nathaniel Berg, Jae Woong Lee, Thanh-Thuy Le, Viola Neudecker, Na Jing, Holger Eltzschig
MicroRNAs were discovered more than 2 decades ago and have profound impact on diverse biological processes. Specific microRNAs have important roles in modulating the innate immune response and their dysregulation has been demonstrated to contribute to inflammatory diseases. MiR-223 in particular, is very highly expressed and tightly regulated in hematopoietic cells. It functions as key modulator for the differentiation and activation of myeloid cells. The central role of miR-223 in myeloid cells, especially neutrophil and macrophage differentiation and activation has been studied extensively...
September 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29860048/necroptosis-in-3-chloro-1-2-propanediol-3-mcpd-dipalmitate-induced-acute-kidney-injury-in-vivo-and-its-repression-by-mir-223-3p
#8
Guoren Huang, Jinli Xue, Xiangjun Sun, Jing Wang, Liangli Lucy Yu
Fatty acid esters of 3-chloro-1, 2-propanediol (3-MCPD) are a group of processing-induced food contaminants with nephrotoxicity. This study investigated whether and how necroptosis played a role in the nephrotoxic effect of 3-MCPD-dipalmitate (2.5 g/kg BW) in C57 BL/6 mice. The results showed that the principal components in necroptosis pathway including receptor-interacting protein 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL) were up-regulated in 3-MCPD-dipalmitate-induced acute kidney injury (AKI)...
August 1, 2018: Toxicology
https://www.readbyqxmd.com/read/29800915/long-non-coding-rna-tug1-protects-renal-tubular-epithelial-cells-against-injury-induced-by-lipopolysaccharide-via-regulating-microrna-223
#9
Yan Xu, Wenyan Deng, Wei Zhang
BACKGROUND: Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE). Long non-coding RNA taurine upregulated gene 1 (lncRNA TUG1) exerted critical regulatory effects on inhibiting cell injury and inflammation. However, its role in LN is still unclear. METHODS: HK-2 cells were treated with lipopolysaccharide (LPS) to simulate cell inflammatory injury. Cell viability and apoptosis, as well as pro-inflammatory factors expression were measured, respectively...
August 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29707878/microrna-223-inhibits-lipopolysaccharide-induced-inflammatory-response-by-directly-targeting-irak1-in-the-nucleus-pulposus-cells-of-intervertebral-disc
#10
Hua Wang, Pan Hao, Hu Zhang, Cuiping Xu, Junyan Zhao
This study was aimed to research the effect of miR-223 on the inflammatory responses induced by lipopolysaccharide (LPS) in nucleus pulposus (NP) cells of rat intervertebral disc. Isolated rat NP cells were induced by LPS. Reverse transcriptase quantitative real-time polymerase chain reaction was used to detect gene expression. To detect protein expression, Western blot and enzyme-linked immunosorbent assay experiments were applied. The putative targeting relationship between miR-223 and Irak1 was determined using dual-luciferase reporter gene assay...
June 2018: IUBMB Life
https://www.readbyqxmd.com/read/29562776/micrornas-of-equine-amniotic-mesenchymal-cell-derived-microvesicles-and-their-involvement-in-anti-inflammatory-processes
#11
Anna Lange-Consiglio, Barbara Lazzari, Claudia Perrini, Flavia Pizzi, Alessandra Stella, Fausto Cremonesi, Emanuele Capra
Cell-derived microvesicles (MVs) are a recently discovered mechanism of cell-to-cell communication. Our previous data show that MVs secreted by equine amniotic mesenchymal-derived cells (AMCs) are involved in downregulation of proinflammatory genes in lipopolysaccharide-stressed equine tendon and endometrial cells. The aim of the present study was to evaluate whether AMC-MVs contain selected microRNAs (miRNAs) involved in inflammation. Two pools of cells, derived from 3 amniotic membranes each, and their respective MVs were collected...
January 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29444433/microrna-223-suppresses-the-canonical-nf-%C3%AE%C2%BAb-pathway-in-basal-keratinocytes-to-dampen-neutrophilic-inflammation
#12
Wenqing Zhou, Arpita S Pal, Alan Yi-Hui Hsu, Theodore Gurol, Xiaoguang Zhu, Sara E Wirbisky-Hershberger, Jennifer L Freeman, Andrea L Kasinski, Qing Deng
MicroRNA-223 is known as a myeloid-enriched anti-inflammatory microRNA that is dysregulated in numerous inflammatory conditions. Here, we report that neutrophilic inflammation (wound response) is augmented in miR-223-deficient zebrafish, due primarily to elevated activation of the canonical nuclear factor κB (NF-κB) pathway. NF-κB over-activation is restricted to the basal layer of the surface epithelium, although miR-223 is detected throughout the epithelium and in phagocytes. Not only phagocytes but also epithelial cells are involved in miR-223-mediated regulation of neutrophils' wound response and NF-κB activation...
February 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29178897/microrna-expression-changes-in-association-with-changes-in-interleukin-1%C3%A3-interleukin10-ratios-produced-by-monocytes-in-autism-spectrum-disorders-their-association-with-neuropsychiatric-symptoms-and-comorbid-conditions-observational-study
#13
Harumi Jyonouchi, Lee Geng, Deanna L Streck, James J Dermody, Gokce A Toruner
BACKGROUND: MicroRNAs (miRNAs) play a major role in regulating immune responses at post-transcriptional levels. Previously, we have reported fluctuating interlukine-1ß (IL-1ß)/IL-10 ratios produced by peripheral blood monocytes (PBMo) in some patients with autism spectrum disorders (ASD). This study examined whether changes in miRNA expression by PBMo are associated with changes in IL-1ß/IL-10 ratios and how such changes are associated with ASD clinical features. METHODS: miRNA expression by purified PBMo from ASD subjects (N = 69) and non-ASD controls (N = 27) were determined by high-throughput sequencing...
November 25, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29162889/identification-of-micrornas-as-potential-cellular-monocytic-biomarkers-in-the-early-phase-of-myocardial-infarction-a-pilot-study
#14
Mariana S Parahuleva, Gerhild Euler, Amar Mardini, Behnoush Parviz, Bernhard Schieffer, Rainer Schulz, Muhammad Aslam
MicroRNA has been increasingly suggested to be involved in vascular inflammation. The aim of this study was to assess the expression profile of miRs as possible novel cellular biomarkers in circulating monocytes in patients with ST-segment elevation myocardial infarction (STEMI). Microarray techniques and TaqMan polymerase chain reaction were used to analyse the global expression of 352 miRNAs in peripheral blood monocytes from healthy donors (n = 20) and patients (n = 24) with acute STEMI. The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29145789/helicobacter-pylori-controls-nlrp3-expression-by-regulating-hsa-mir-223-3p-and-il-10-in-cultured-and-primary-human-immune-cells
#15
Suneesh Kumar Pachathundikandi, Steffen Backert
Inflammasome-mediated production of mature IL-1β and IL-18 cytokines represents an important innate immune response against infecting pathogens. Helicobacter pylori, one of the most successful and persistent human pathogens, induces severe inflammation leading to gastritis and more serious gastric diseases. H. pylori modulates different immune responses for its survival and inflammasome signaling is manipulated by the cag pathogenicity island ( cagPAI), urease and VacA cytotoxin. Here we report that H. pylori regulates NLRP3 expression, an inflammasome forming regulator, in infected THP-1 monocytes...
January 2018: Innate Immunity
https://www.readbyqxmd.com/read/29083107/increased-mir-223-expression-in-foetal-organs-is-a-signature-of-acute-chorioamnionitis-with-systemic-consequences
#16
JoonHo Lee, Chong Jai Kim, Jung-Sun Kim, Deug-Chan Lee, Sejin Ahn, Bo Hyun Yoon
Acute chorioamnionitis, frequently observed in preterm placentas, is a major risk factor for the development of infection and non-infection-related adverse perinatal outcomes. MicroRNAs play important roles in immune cell development and function as well as in the development of cancers and neurologic diseases. We sought to investigate the changes in microRNA-223 (miR-223) expression and the functional significance of the changes in miR-223 expression in foetal organs in the presence of acute chorioamnionitis...
February 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28931657/neutrophil-transfer-of-mir-223-to-lung-epithelial-cells-dampens-acute-lung-injury-in-mice
#17
Viola Neudecker, Kelley S Brodsky, Eric T Clambey, Eric P Schmidt, Thomas A Packard, Bennett Davenport, Theodore J Standiford, Tingting Weng, Ashley A Fletcher, Lea Barthel, Joanne C Masterson, Glenn T Furuta, Chunyan Cai, Michael R Blackburn, Adit A Ginde, Michael W Graner, William J Janssen, Rachel L Zemans, Christopher M Evans, Ellen L Burnham, Dirk Homann, Marc Moss, Simone Kreth, Kai Zacharowski, Peter M Henson, Holger K Eltzschig
Intercellular transfer of microRNAs can mediate communication between critical effector cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial cells could alter mucosal gene expression during acute lung injury. Pulmonary-epithelial microRNA profiling during coculture of alveolar epithelial cells with polymorphonuclear neutrophils (PMNs) revealed a selective increase in lung epithelial cell expression of microRNA-223 ( miR-223 ). Analysis of PMN-derived supernatants showed activation-dependent release of miR-223 and subsequent transfer to alveolar epithelial cells during coculture in vitro or after ventilator-induced acute lung injury in mice...
September 20, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28883474/plasma-exosomal-mir-223-expression-regulates-inflammatory-responses-during-cardiac-surgery-with-cardiopulmonary-bypass
#18
Kin-Shing Poon, Kalaiselvi Palanisamy, Shih-Sheng Chang, Kuo-Ting Sun, Kuen-Bao Chen, Ping-Chun Li, Tso-Chou Lin, Chi-Yuan Li
Cardiopulmonary bypass (CPB) induces inflammatory responses, and effective endogenous homeostasis is important for preventing systemic inflammation. We assessed whether plasma exosomal microRNAs in patients undergoing cardiac surgery with CPB are involved in the regulation of inflammatory responses. Plasma samples were isolated from CPB patients (n = 21) at 5 specified time points: pre-surgery, pre-CPB and 2 hours (h), 4 h and 24 h after CPB began. Plasma TNF-α expression was increased after CPB began compared to that in the pre-surgery samples...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28804446/induction-of-mir-155-after-brain-injury-promotes-type-1-interferon-and-has-a-neuroprotective-effect
#19
Emily B Harrison, Katy Emanuel, Benjamin G Lamberty, Brenda M Morsey, Min Li, Matthew L Kelso, Sowmya V Yelamanchili, Howard S Fox
Traumatic brain injury (TBI) produces profound and lasting neuroinflammation that has both beneficial and detrimental effects. Recent evidence has implicated microRNAs (miRNAs) in the regulation of inflammation both in the periphery and the CNS. We examined the expression of inflammation associated miRNAs in the context of TBI using a mouse controlled cortical impact (CCI) model and found increased levels of miR-21, miR-223 and miR-155 in the hippocampus after CCI. The expression of miR-155 was elevated 9-fold after CCI, an increase confirmed by in situ hybridization (ISH)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28742402/association-of-il-10-regulating-micrornas-in-peripheral-blood-mononuclear-cells-with-the-pathogenesis-of-autoimmune-thyroid-disease
#20
Yukina Takuse, Mikio Watanabe, Naoya Inoue, Ritsuko Ozaki, Hiroshi Ohtsu, Minori Saeki, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatani
Interleukin (IL)-10 is known to suppress inflammation in autoimmune diseases. IL-10 can be regulated by miRNAs. To elucidate the involvement of miRNAs that regulate IL-10 expression with the pathogenesis of autoimmune thyroid disease (AITD), we examined the expression levels of hsa-miR-27a-3p, hsa-miR-98-5p, hsa-miR-106a-5p, and hsa-miR-223-3p in peripheral blood mononuclear cells (PBMCs) from 43 patients with Graves' disease (GD), 38 patients with Hashimoto's disease (HD), and 21 healthy volunteers. We evaluated the association between the expression levels of four miRNAs and intracellular expression of IL-10 in PBMCs from 11 healthy volunteers...
August 2017: Immunological Investigations
keyword
keyword
163333
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"