Ana Flávia Teixeira Rossi, Aline Cristina Targa Cadamuro, Joice Matos Biselli-Périco, Kátia Ramos Moreira Leite, Fábio Eduardo Severino, Patricia P Reis, José Antonio Cordeiro, Ana Elizabete Silva
Helicobacter pylori cause chronic inflammation favouring gastric carcinogenesis, and its eradication may prevent malignant transformation. We evaluated whether H. pylori infection and its eradication modify the expression of inflammatory mediators in patients with chronic gastritis. Furthermore, we assessed whether microRNAs modulate inflammatory pathways induced by H. pylori and identified miRNA-gene interaction networks. mRNA and protein expression of TNFA, IL6, IL1B, IL12A, IL2 and TGFBRII and miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples from 20 patients with chronic gastritis H...
October 2016: Cellular Microbiology