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Clostridium histolyticum

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https://www.readbyqxmd.com/read/30071789/five-year-results-after-collagenase-treatment-of-dupuytren-disease
#1
Jens C Werlinrud, Karina L Hansen, Søren Larsen, Jens Lauritsen
This study assesses the joint-specific sustained effect of collagenase clostridium histolyticum treatment of Dupuytren disease over a 5-year follow-up period. The study includes 107 consecutive treatments in patients with extension deficits greater than 20° affecting the metacarpophalangeal or proximal interphalangeal joints. Success was defined as no follow-up treatment due to relapse or maintained extension deficit less than 20°. The 5-year estimate of no follow-up treatment was 79% (95% CI: 64-88) for metacarpophalangeal and 49% (95% CI: 26-69) for proximal interphalangeal joints, which was a significant difference (log-rank test, p = 0...
August 2, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/30059716/multi-institutional-prospective-analysis-of-intralesional-injection-of-collagenase-clostridium-histolyticum-tunical-plication-and-partial-plaque-excision-and-grafting-for-the-management-of-peyronie-s-disease
#2
Faysal A Yafi, Linley Diao, Kenneth J DeLay, Ling DeYoung, Riad Talib, Laith Alzweri, Gerald Brock, Wayne J G Hellstrom, Georgios Hatzichristodoulou
OBJECTIVE: To compare in a prospective, non-randomized fashion the outcomes of Collagenase Clostridium Histolyticum (CCH) and surgical interventions (tunical plication [TP] and partial plaque excision and grafting [PEG]) in patients with PD. Intralesional injection of CCH is the only Food and Drug Administration-approved non-surgical intervention for Peyronie's disease (PD). MATERIALS AND METHODS: Between 6/2015 and 1/2017, 57 patients with PD and dorsal, dorsolateral and/or lateral penile curvatures 30-90 degrees were included in this study...
July 27, 2018: Urology
https://www.readbyqxmd.com/read/30039732/a-post-hoc-analysis-of-dupuytren-contracture-treated-with-collagenase-clostridium-histolyticum-across-disease-stages
#3
Gary M Pess, Maj Sundbom, Koo Wilson, Daniel Lindqvist, Lars B Dahlin
This post hoc analysis from a multicenter study (NCT01674634) was designed to evaluate the efficacy of collagenase Clostridium histolyticum (CCH) treatment in patients with different stages of Dupuytren contracture. Previously untreated patients who received two concurrent injections of CCH in two affected joints in the same finger were assessed by disease severity (Tubiana stage). The mean (SD) improvement in total fixed flexion contraction (FFC) 31 days post-CCH treatment in 181 patients was: 71.1 (36.5)% for Tubiana I, 77...
July 24, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/30035850/ca-2-induced-orientation-of-tandem-collagen-binding-domains-from-clostridial-collagenase-colg-permits-two-opposing-functions-of-collagen-fibril-formation-and-retardation
#4
Perry Caviness, Ryan Bauer, Keisuke Tanaka, Katarzyna Janowska, J Randy Roeser, Dawn Weir, Jes Sanders, Christopher Ruth, Osamu Matsushita, Joshua Sakon
To penetrate host tissues, histotoxic clostridia secrete virulence factors including enzymes to hydrolyze extracellular matrix. Clostridium histolyticum, recently renamed as Hathewaya histolytica, produces two classes of collagenase (ColG and ColH). The high-speed AFM study showed that ColG collagenase moves unidirectionally to plane collagen fibril and re-bundles fibril when stalled [1]. The structural explanation of the roles for the tandem collagen-binding segment (CBDs) is illuminated by its calcium-bound crystal structure at 1...
July 23, 2018: FEBS Journal
https://www.readbyqxmd.com/read/30012294/development-of-collagenase-treatment-for-dupuytren-disease
#5
REVIEW
Marie A Badalamente, Lawrence C Hurst
Proof-of-principle, basic-science studies, using a rat-tail tendon model and surgically removed Dupuytren cords, began collagenase Clostridium histolyticum (CCH) development. Clinical studies in humans were then conducted, where the primary endpoint was reduction in contracture to within 0° to 5° of extension. Phase 2 studies, which confirmed the optimal dose of collagenase as 0.58 mg, showed injectable CCH reduced contractures in MP and PIP joints to within 0° to 5° in many joints and was well tolerated...
August 2018: Hand Clinics
https://www.readbyqxmd.com/read/29984532/a-systematic-literature-review-of-the-effect-of-anthocyanins-on-gut-microbiota-populations
#6
REVIEW
E O Igwe, K E Charlton, Y C Probst, K Kent, M E Netzel
BACKGROUND: Evidence has shown that anthocyanins, a subclass of polyphenol, are metabolised in the gut, modulate bacterial species and exert bioactive effects through this interaction. METHODS: A systematic literature review was undertaken to determine the level of current evidence for the association between anthocyanin intake and changes in gut microbiota populations. The studies included were also assessed for the different techniques used in microbiota determination...
July 8, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/29975270/percutaneous-needle-fasciotomy-versus-collagenase-treatment-for-dupuytren-contracture-a-randomized-controlled-trial-with-a-two-year-follow-up
#7
Joakim Strömberg, Allan Ibsen Sörensen, Jan Fridén
BACKGROUND: Local disruption of the cord that causes contracture of the finger in Dupuytren disease can be achieved either through mechanical division by percutaneous needle fasciotomy (PNF) or through enzymatic digestion by injectable collagenase Clostridium histolyticum (CCH). This study was designed to compare clinical and patient-reported outcomes between patients who had been treated with each method. METHODS: A prospective, randomized, single-blinded, controlled trial was designed and included 156 patients with a contracture of the metacarpophalangeal (MCP) joint of ≥20°...
July 5, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29908867/plaque-calcification-an-important-predictor-of-collagenase-clostridium-histolyticum-treatment-outcomes-for-men-with-peyronie-s-disease
#8
Kevin Wymer, Matthew Ziegelmann, Joshua Savage, Tobias Kohler, Landon Trost
OBJECTIVE: To compare outcomes of men with or without calcified plaques undergoing collagenase clostridium histolyticum (CCH) injections for Peyronie's Disease (PD) and identify predictors of CCH success. MATERIAL AND METHODS: From March 2014 through January 2017, data were prospectively collected on 192 patients who underwent 1-4 cycles of CCH for the treatment of PD. Of these, 115 completed ≥2 CCH cycles and had data on curvature assessment. The primary outcome was the percentage of men with >20% improvement in composite curvature...
June 14, 2018: Urology
https://www.readbyqxmd.com/read/29791971/predictors-of-treatment-success-after-collagenase-clostridium-histolyticum-injection-for-peyronie-s-disease-development-of-a-nomogram-from-a-multicentre-single-arm-non-placebo-controlled-clinical-study
#9
Andrea Cocci, Giorgio Ivan Russo, Alberto Briganti, Andrea Salonia, Giovanni Cacciamani, Marco Capece, Marco Falcone, Massimiliano Timpano, Gianmartin Cito, Paolo Verze, Bruno Giammusso, Giuseppe Morgia, Vincenzo Mirone, Andrea Minervini, Mauro Gacci, Tommaso Cai, Sergio Serni, Marco Carini, Gianluca Giubilei, Nicola Mondaini
OBJECTIVE: To build a nomogram able to predict treatment success after collagenase Clostridium histolyticum (CCH) for Peyronie's disease (PD). MATERIALS AND METHODS: Between November 2016 and November 2017, we enrolled 135 patients with PD into a multicentre single-arm prospective study. All patients enrolled received CCH treatment. Success of therapy was defined as a decrease in penile curvature (PC) of ≥20° from baseline. Treatment satisfaction was assessed using a scale from 1 to 10, and high satisfaction was arbitrarily defined as a score of ≥8...
May 23, 2018: BJU International
https://www.readbyqxmd.com/read/29774446/contemporary-review-of-peyronie-s-disease-treatment
#10
REVIEW
Edward Capoccia, Laurence A Levine
PURPOSE: To analyze the literature on the current treatment options for Peyronie's disease (PD). RECENT FINDINGS: Intracavernosal injection therapy using collagenase clostridium histolyticum (CCH) has been widely adopted since its FDA approval in 2013. Based on the current evidence, it appears to be moderately efficacious for men with mild curvatures. Although a recent study has shown similar outcomes using a modified protocol requiring fewer injections, CCH remains an expensive medication...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29770338/basic-fibroblast-growth-factor-fused-with-tandem-collagen-binding-domains-from-clostridium-histolyticum-collagenase-colg-increases-bone-formation
#11
Hiroyuki Sekiguchi, Kentaro Uchida, Osamu Matsushita, Gen Inoue, Nozomu Nishi, Ryo Masuda, Nana Hamamoto, Takaki Koide, Shintaro Shoji, Masashi Takaso
Basic fibroblast growth factor 2 (bFGF) accelerates bone formation during fracture healing. Because the efficacy of bFGF decreases rapidly following its diffusion from fracture sites, however, repeated dosing is required to ensure a sustained therapeutic effect. We previously developed a fusion protein comprising bFGF, a polycystic kidney disease domain (PKD; s2b), and collagen-binding domain (CBD; s3) sourced from the Clostridium histolyticum class II collagenase, ColH, and reported that the combination of this fusion protein with a collagen-like peptide, poly(Pro-Hyp-Gly)10 , induced mesenchymal cell proliferation and callus formation at fracture sites...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29761688/collagenase-clostridium-histolyticum-a-novel-medical-treatment-for-peyronie-s-disease
#12
Amr Abdel Raheem, Mark Johnson, David Ralph, Giulio Garaffa
INTRODUCTION: Peyronie's disease (PD) affects up to 9% of the male population. PD causes scarring of the tunica albuginea of the penis which leads to penile deformity making sexual intercourse difficult or impossible. PD also causes significant psychological, emotional and relationship difficulties for both patient and partner. Up until the licencing of Collagenase clostridium histolyticum (CCH) (Xiapex®, Xiaflex®), surgical correction of the penile deformity was the mainstay of treatment...
August 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29741424/morphological-patterns-of-the-pretendinous-cord-in-dupuytren-s-disease-a-predictor-of-clinical-outcome
#13
P Vanek, J Strömberg, J Fridén, Y Aurell
The morphology of the pretendinous cord in Dupuytren's disease is poorly described in vivo and especially with respect to recurrence after treatment. This prospective study was designed to describe the morphology of Dupuytren's cords by ultrasound and to identify possible correlation between the ultrasonographic characteristics of these cords and the clinical outcomes two years after treatment. Thirty-nine patients with a contracture of at least 20° in the metacarpophalangeal (MCP) joint, who were scheduled for local treatment by either injectable collagenase clostridium histolyticum (CCH) or percutaneous needle fasciotomy (PNF), were examined by ultrasound...
August 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29733116/collagenase-clostridium-histolyticum-for-the-treatment-of-peyronie-s-disease-a-prospective-italian-multicentric-study
#14
M Capece, A Cocci, G Russo, G Cito, G Giubilei, G Cacciamani, G Garaffa, M Falcone, M Timpano, G Tasso, F Sessa, R Campi, F Di Maida, T Cai, G Morelli, B Giammusso, P Verze, A Palmieri, D Ralph, V Mirone, N Mondaini
Peyronie's disease (PD) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of PD and is indicated in patients with palpable plaque and curvature deformity of at least 30° of curvature. However, only few monocentric studies are available in the current literature and this is the first national multicentric study focusing on this new treatment. In five Italian centres, 135 patients have completed the treatment with three injections of CCH using Ralph's shortened modified protocol...
May 7, 2018: Andrology
https://www.readbyqxmd.com/read/29726655/-collagenase-clostridium-histolyticum-for-peyronie-s-disease-a-new-minimally-invasive-and-effective-treatment
#15
REVIEW
Hao-Cheng Lin, Hai-Tao Zhang, Hui Jiang
The treatment of Peyronie's disease has been a challenge to urologists, as most of the current oral medications are considered hardly valid and the rest of the therapies require strict control of indications, some of which remain controversial, while the final surgical option may be associated with complications such as penile shortening or erectile dysfunction. Collagenase clostridium histolyticum has been proved to be effective in dissolving the penile cavernosal plaque and approved by the Food and Drug Administration of the USA as the first drug to be used for the treatment of Peyronie's disease...
September 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29726315/the-risk-of-skin-tear-in-dupuytren-s-disease-when-treated-with-collagenase
#16
Christian Fagernæs, Susanne Mallet
INTRODUCTION: The purpose of this study was to explore if there was a correlation between joint level and degree of contracture on the one hand and the risk of skin tear in Dupuytren's disease (DD) on the other, when treated with collagenase from Clostridium histolyticum. No trial or study has explored the risk of skin tear as primary outcome in a population that has not been treated for DD before. METHODS: A retrospective study of prospectively collected data was performed on patients with DD treated with collagenase from 1 August 2012 to 1 April 2014...
May 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29706551/anesthesia-for-collagenase-clostridium-histolyticum-injection-in-patients-with-dupuytren-disease-a-cohort-analysis
#17
Rafael Sanjuan-Cerveró, Francisco J Carrera-Hueso, Pedro Vazquez-Ferreiro, Clayton A Peimer
Procedural pain is one of the most common adverse effects reported by patients with Dupuytren disease (DD) treated with collagenase clostridium histolyticum (CCH). The aim of this study was to assess the effectiveness of wrist block before CCH injection in reducing procedural pain and to analyze its impact on adverse effects. We performed a prospective, single-center study in which we compared two groups of patients in a consecutive cohort. In the first group (NO-BLOCK), wrist block was only performed before finger extension, whereas in the second group (BLOCK), it was performed before CCH injection and finger extension...
April 12, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29699756/predictive-factors-of-patients-and-their-partners-sexual-function-improvement-after-collagenase-clostridium-histolyticum-injection-for-peyronie-s-disease-results-from-a-multi-center-single-arm-study
#18
Andrea Cocci, Giorgio Ivan Russo, Andrea Salonia, Gianmartin Cito, Federica Regis, Gaia Polloni, Gianluca Giubilei, Giovanni Cacciamani, Marco Capece, Marco Falcone, Isabella Greco, Massimiliano Timpano, Andrea Minervini, Mauro Gacci, Tommaso Cai, Giulio Garaffa, Bruno Giammusso, Davide Arcaniolo, Vincenzo Mirone, Nicola Mondaini
BACKGROUND: Collagenase Clostridium histolyticum (CCH; Xiapex) injections represent the only licensed medical treatment for Peyronie's disease (PD). AIM: To evaluate the efficacy and safety of CCH injections in men with stable PD, using a modified treatment protocol and to assess partners' bother improvement in a large cohort of White-European sexually active heterosexual men treated in a single tertiary-referral center. METHODS: All the 135 patients enrolled underwent a thorough assessment, which included history taking, physical examination, and pharmacologically induced artificial erection test (intra-cavernous injection) to assess the degree of penile curvature (PC) at baseline and after the completion of the treatment...
May 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29667480/the-human-gut-microbiota-metabolism-and-perspective-in-obesity
#19
Aline Corado Gomes, Christian Hoffmann, João Felipe Mota
The gut microbiota has been recognized as an important factor in the development of metabolic diseases such as obesity and is considered an endocrine organ involved in the maintenance of energy homeostasis and host immunity. Dysbiosis can change the functioning of the intestinal barrier and the gut-associated lymphoid tissues (GALT) by allowing the passage of structural components of bacteria, such as lipopolysaccharides (LPS), which activate inflammatory pathways that may contribute to the development of insulin resistance...
April 18, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29599391/dupuytren-treatment-effectiveness-trial-detect-a-protocol-for-prospective-randomised-controlled-outcome-assessor-blinded-three-armed-parallel-1-1-1-multicentre-trial-comparing-the-effectiveness-and-cost-of-collagenase-clostridium-histolyticum-percutaneous-needle
#20
Mikko P Räisänen, Teemu Karjalainen, Harry Göransson, Aleksi Reito, Hannu Kautiainen, Antti Malmivaara, Olli V Leppänen
INTRODUCTION: Dupuytren's contracture (DC) is a chronic fibroproliferative disorder of the palmar fascia which leads to flexion contracture in one or more fingers. There is no definitive cure for DC, and treatment aims at relieving symptoms by releasing the contracture using percutaneous or operative techniques. METHODS AND ANALYSIS: We planned a prospective, randomised, controlled, outcome assessor-blinded, three-armed parallel 1:1:1, multicentre trial comparing the effectiveness and cost of (1) collagenase clostridium histolyticum injection followed by limited fasciectomy in non-responsive cases, (2) percutaneous needle fasciotomy followed by limited fasciectomy in non-responsive cases and (3) primary limited fasciectomy during short-term and long-term follow-up for Tubiana I-III stages DC...
March 28, 2018: BMJ Open
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