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Mesothelioma testicular

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https://www.readbyqxmd.com/read/30030093/a-bilateral-metachronous-mesothelioma-of-the-tunica-vaginalis
#1
Alejandro Abello, Jennifer Steinkeler, Anurag K Das
This is a unique case of bilateral metachronous testicular mesothelioma of the tunica vaginalis. Testicular mesothelioma is a rare entity found in patients with or without asbestos occupational exposure. The tumor most commonly presents as a unilateral testicular mass. More rare presentations include bilateral synchronous or metachronous tumors. Treatment is with surgical resection and prognosis is not generally favorable. The benefits of adjuvant therapy with radiation or chemotherapy remain unknown and further studies are needed...
July 17, 2018: Urology
https://www.readbyqxmd.com/read/29948422/preoperative-circulating-tumor-dna-in-patients-with-peritoneal-carcinomatosis-is-an-independent-predictor-of-progression-free-survival
#2
Joel M Baumgartner, Victoria M Raymond, Richard B Lanman, Lisa Tran, Kaitlyn J Kelly, Andrew M Lowy, Razelle Kurzrock
BACKGROUND: Next-generation sequencing (NGS) is a useful tool for detecting genomic alterations in circulating tumor DNA (ctDNA). To date, most ctDNA tests have been performed on patients with widely metastatic disease. Patients with peritoneal carcinomatosis (metastases) present unique prognostic and therapeutic challenges. We therefore explored preoperative ctDNA in patients with peritoneal metastases undergoing surgery. METHODS: Patients referred for surgical resection of peritoneal metastases underwent preoperative blood-derived ctDNA analysis (clinical-grade NGS [68-73 genes])...
August 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29498494/potential-hot-spot-for-de-novo-mutations-in-ptch1-gene-in-gorlin-syndrome-patients-a-case-report-of-twins-from-croatia
#3
Vesna Musani, Petar Ozretić, Diana Trnski, Maja Sabol, Sanja Poduje, Mateja Tošić, Mirna Šitum, Sonja Levanat
We describe a case of twins with sporadic Gorlin syndrome. Both twins had common Gorlin syndrome features including calcification of the falx cerebri, multiple jaw keratocysts, and multiple basal cell carcinomas, but with different expressivity. One brother also had benign testicular mesothelioma. We propose this tumor type as a possible new feature of Gorlin syndrome. Gorlin syndrome is a rare autosomal dominant disorder characterized by both developmental abnormalities and cancer predisposition, with variable expression of various developmental abnormalities and different types of tumors...
February 28, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29334678/genome-evolution-analysis-of-recurrent-testicular-malignant-mesothelioma-by-whole-genome-sequencing
#4
Shigeng Zhang, Qi Zhang, Qing Sun, Jinlong Tang, Jimin Chen, Na Ji, Yichun Zheng, Francia Fang, Wanjun Lei, Pengpeng Li, Nan Zhang
BACKGROUND/AIMS: Malignant mesothelioma of the tunica vaginalis testis is a rare and lethal disease. The genomic characteristics and genetic changes of tumor cells during the progression of this disease are unknown. METHODS: we performed whole-genome sequencing of four successive tumor samples derived from surgery and a blood sample in a single patient. RESULTS: All tumors were found to have significant C-to-T and T-to-C mutations, and amplification of copy number in chromosomes 1 and 12 were notified in all tumor samples...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29285372/malignant-mesothelioma-of-the-tunica-vaginalis-testis-a-case-report-and-literature-review
#5
Neng Zhang, Ni Fu, Su Peng, Xu Luo
Malignant mesothelioma of the tunica vaginalis testis is an extremely rare tumor without specific clinical manifestations, mainly including hydrocele formation and a painless mass. We herein present the case of a patient with hydrocele of the left testis, without any other complaints. Tunica vaginalis subinvolution was performed, and postoperative pathological examination revealed a malignant mesothelioma arising from the left tunica vaginalis testis. Whole-body positron emission tomography-computed tomography (PET-CT) and subsequent abdominal and pelvic magnetic resonance imaging (MRI) revealed no evidence of local lymphadenopathy...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28791219/bilateral-malignant-mesothelioma-of-tunica-vaginalis-a-case-report-on-rare-presentation
#6
Ashhad A Shaikh, Kishor V Naik, Shisir N Shetty, Noor N Ansari, Pallavi S Babhale
Malignant mesothelioma involving the para-testicular tunica is extremely rare and an aggressive tumor. Bilateral malignant mesothelioma of the tunica vaginalis is not reported previously in the literature. Rarity of the disease, absence of any specific clinical and radiological findings makes the preoperative diagnosis difficult. Aggressive surgical approach is the key to successful management with high inguinal orchiectomy and scrotectomy appears to be optimal treatment in patients with localized disease.
September 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28168071/two-case-reports-of-benign-testicular-mesothelioma-and-review-of-the-literature
#7
Cristobal Ramirez Sevilla, Carme Admella Salvador, Josep Feliu Canaleta, Juan Llopis Manzanera, Miguel Angel Barranco Sanz, Juan Antoni Romero Martin, Sergi Bernal Salguero
Mesothelioma is usually diagnosed in people over the age of 50 with large history of asbestos-related exposure. It is frequently located in pleural cavity, peritoneum, and pericardium. At the testicles the mesothelioma had been reported first in 1957 like a malignant non-germ-cells tumor. The objective is to present two case reports of benign testicular mesothelioma and review of the literature.
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28118455/trends-and-patterns-of-disparities-in-cancer-mortality-among-us-counties-1980-2014
#8
Ali H Mokdad, Laura Dwyer-Lindgren, Christina Fitzmaurice, Rebecca W Stubbs, Amelia Bertozzi-Villa, Chloe Morozoff, Raghid Charara, Christine Allen, Mohsen Naghavi, Christopher J L Murray
Introduction: Cancer is a leading cause of morbidity and mortality in the United States and results in a high economic burden. Objective: To estimate age-standardized mortality rates by US county from 29 cancers. Design and Setting: Deidentified death records from the National Center for Health Statistics (NCHS) and population counts from the Census Bureau, the NCHS, and the Human Mortality Database from 1980 to 2014 were used. Validated small area estimation models were used to estimate county-level mortality rates from 29 cancers: lip and oral cavity; nasopharynx; other pharynx; esophageal; stomach; colon and rectum; liver; gallbladder and biliary; pancreatic; larynx; tracheal, bronchus, and lung; malignant skin melanoma; nonmelanoma skin cancer; breast; cervical; uterine; ovarian; prostate; testicular; kidney; bladder; brain and nervous system; thyroid; mesothelioma; Hodgkin lymphoma; non-Hodgkin lymphoma; multiple myeloma; leukemia; and all other cancers combined...
January 24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27995857/malignant-mesothelioma-of-the-tunica-vaginalis-a-rare-case-report-and-description-of-multimodal-treatment
#9
Eric D Andresen, Grant Henning, Matthew A Uhlman, Amit Gupta
Malignant mesothelioma is an uncommon neoplasm that develops from serous surfaces, and rarely from the tunica vaginalis. Although atypical in any location, paratesticular presentation is exceedingly infrequent as only 0.3% to 1.4% of mesothelioma cases arise from the tunica vaginalis. Fewer than 300 cases have been reported with very few descriptions of long term follow up and multimodal therapy. Here we describe a patient with 2 years of follow up for metastatic mesothelioma treated with orchiectomy, chemotherapy and robot-assisted laparoscopic retroperitoneal lymph node dissection...
December 2016: Canadian Journal of Urology
https://www.readbyqxmd.com/read/27871980/low-dose-assessment-of-the-carcinogenicity-of-furan-in-male-f344-n-nctr-rats-in-a-2-year-gavage-study
#10
Linda S Von Tungeln, Nigel J Walker, Greg R Olson, Maria C B Mendoza, Robert P Felton, Brett T Thorn, M Matilde Marques, Igor P Pogribny, Daniel R Doerge, Frederick A Beland
Furan is a volatile organic chemical that is a contaminant in many common foods. Furan is hepatocarcinogenic in mice and rats; however, the risk to humans from dietary exposure to furan cannot be estimated accurately because the lowest tested dose of furan in a 2-year bioassay in rats gave nearly a 100% incidence of cholangiocarcinoma. To provide bioassay data that can be used in preparing risk assessments, the carcinogenicity of furan was determined in male F344/N Nctr rats administered 0, 0.02, 0.044, 0.092, 0...
January 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27648280/long-term-outcomes-following-post-operative-radiotherapy-for-stage-i-ii-testicular-seminoma-an-australasian-single-institution-experience
#11
Wee Loon Ong, Lester Nazareth, Benjamin Hindson, Bronwyn Matheson, Jeremy L Millar
INTRODUCTION: The aim of the study is to review the long-term oncological outcomes and adverse effects of post-operative radiotherapy (PORT) for Stage I/II seminoma patients in an Australian radiation treatment centre. METHODS: This is a retrospective study of 125 patients with Stage I/II seminoma treated with PORT at the Alfred Health Radiation Oncology Service between 1992 and 2013. Patients were linked to the Victorian Cancer Registry to enable confirmation of survival and diagnosis of secondary malignancies (SM)...
September 2016: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27419370/expression-of-neural-cell-adhesion-molecule-l1-cd171-in-neuroectodermal-and-other-tumors-an-immunohistochemical-study-of-5155-tumors-and-critical-evaluation-of-cd171-prognostic-value-in-gastrointestinal-stromal-tumors
#12
Shingo Inaguma, Zengfeng Wang, Jerzy P Lasota, Markku M Miettinen
The neural cell adhesion molecule L1 (CD171) is a multidomain type 1 membrane glycoprotein of the immunoglobulin superfamily important in the nervous system development, kidney morphogenesis, and maintenance of the immune system. Recent studies reported CD171 expression being associated with adverse clinical outcome in different types of cancer and there has been a growing interest in targeting this cell membrane molecule on neoplastic cells by chimeric antigen receptor redirected T lymphocytes or specific antibodies...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27278595/the-legacy-of-the-f344-rat-as-a-cancer-bioassay-model-a-retrospective-summary-of-three-common-f344-rat-neoplasms
#13
REVIEW
Robert R Maronpot, Abraham Nyska, Jennifer E Foreman, Yuval Ramot
The Fischer 344 (F344) rat was used by the National Toxicology Program (NTP) for over 5 decades for toxicity and carcinogenicity studies. However, in 2006, the NTP decided to switch to a different rat stock due largely to high background control incidences of Leydig cell tumors (LCTs) and mononuclear cell leukemia (MNCL), also known as large granular lymphocytic (LGL) leukemia. In the current review, we aim (1) to provide a summary of NTP bioassays with treatment-associated effects involving MNCL and LCTs in addition to male F344-specific tunica vaginalis mesothelioma (TVM); (2) to describe important pathobiological differences between these F344 rat tumor responses and similar target tissue-tumor response in humans; and (3) to present the NTP reasons for switching away from the F344 rat...
September 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27040844/diffuse-malignant-mesothelioma-and-synchronous-lung-cancer-a-clinicopathological-study-of-18-cases
#14
Kelly J Butnor, Noel A Brownlee, Annabelle Mahar, Elizabeth N Pavlisko, Thomas A Sporn, Victor L Roggli
OBJECTIVES: To examine the clinicopathologic characteristics of individuals with diffuse malignant mesothelioma (DMM) occurring concurrently with lung cancer (LC). MATERIALS AND METHODS: A database of approximately 3800 patients with DMM was reviewed, from which 18 patients (0.5%) who had synchronous LC were identified. The clinicopathologic features, as well as the occupational exposure history and fiber burden analysis data were examined. RESULTS: The patient median age was 68 years (range 58-84 years)...
May 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/26894775/cutaneous-metastases-from-malignant-mesothelioma-of-the-tunica-vaginalis-testis
#15
Patricia Hispán, José C Pascual, Iris González, Diego Bravo, Gloria Peiró
Mesotheliomas are uncommon tumors arising from mesothelial cells lining the serous membranes of the pleura, pericardium, peritoneum, and tunica vaginalis testis. Less than 100 cases arising from the tunica vaginalis testis have been published and, to our knowledge, only 5 cases of cutaneous involvement from these tumors have been reported. We report an additional case with fatal outcome. A 93-year-old man presented with multiple polypoid nodules on the left scrotum. Ulceration was also present, and a firm 5-cm palpable testicular mass was also found...
March 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26773348/well-differentiated-papillary-mesothelioma-of-the-tunica-vaginalis
#16
Wei Keith Tan, Mae-Yen Tan, Hui Meng Tan, Rajadurai Pathmanathan, Wei Phin Tan
A 39-year-old man presented with painless scrotal swelling for 2 months. He denied any asbestos exposure but worked with wall and ceiling plaster. Physical exam revealed a large right scrotum which transilluminated. Scrotal ultrasonography revealed a large right hydrocele and a polypoidal mass along the anterior wall of the scrotum. Magnetic resonance imaging of the abdomen and computed tomography of the chest showed no metastases. He underwent a right inguinal scrotal exploration and wide excision of tunica vaginalis and a partial epididymectomy...
April 2016: Urology
https://www.readbyqxmd.com/read/26435024/extremely-rare-tumour-malignant-mesothelioma-of-tunica-vaginalis-testis
#17
T Jankovichova, M Jankovich, D Ondrus, K Kajo, J Dubravicky, J Breza
INTRODUCTION: Malignant mesothelioma of tunica vaginalis testis is an extremely rare tumour. It is often caused by exposition to asbestos, however, more often its occurrence is sporadic. The diagnosis is usually set secondarily during hydrocele surgery. This type of tumour should be considered in cases with with atypical hydrocele, especially haematocele or atypical shape of seminal covering. RESULTS: A case of an asbestos-exposed patient with described disease and long-term hydrocele is presented...
2015: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/26223989/preoperative-cytological-diagnosis-of-malignant-mesothelioma-of-tunica-vaginalis
#18
Arghya Bandyopadhyay, Shubham Bhattacharya, Karabi Konar
Malignant mesothelioma of tunica vaginalis testis is a rare aggressive neoplasm with ∼200 cases reported so far. A correct preoperative diagnosis of this rare tumor is difficult. Fine-needle aspiration cytology (FNAC) is a rapid and inexpensive diagnostic tool that may prove helpful in such cases. Very few cases have been diagnosed on cytology so far, and the descriptions of the cytological features have rarely been described in the literature. In this report we present the cytological features of malignant mesothelioma of tunica vaginalis testis which was diagnosed by FNAC and subsequently confirmed by histopatholoy and immunohistochemical (IHC) studies...
October 2015: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/26191318/primary-adenomatoid-tumor-of-the-testis-report-of-a-case-and-review-of-literature
#19
REVIEW
Binwu Sheng, Yin-Ping Zhang, Huan-Huan Wei, Mao Ma, Xunyi Nan
Adenomatoid tumor (AT) is an extremely rare benign tumor in the testis of infants. A case of 14-month-old boy with testicular adenomatoid tumor was reported in this study. On physical examination, a smooth solid nodule sized 8 mm could be palpated with little tenderness on the head of the right testis. It could be clearly revealed by B ultrasonic scanning and computerized tomography. The patient underwent right radical orchiectomy. In postoperative histopathological study, the tumor was characterized by diffuse sheets of epithelioid cell and desmo-stroma structures...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26116329/malignant-mesothelioma-of-the-tunica-vaginalis-a-rare-neoplasm-case-report-and-literature-review
#20
REVIEW
Manuel Segura-González, Jorge Urias-Rocha, Jorge Castelán-Pedraza
No abstract text is available yet for this article.
December 2015: Clinical Genitourinary Cancer
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