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Plasmablastic lymphoma

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https://www.readbyqxmd.com/read/27900846/plasmablastic-lymphoma-mimicking-carcinomatosis-a-case-report-and-review-of-the-literature
#1
Andrea M Olofson, Eric Y Loo, Paul A Hill, Xiaoying Liu
First identified as a distinct disease entity in HIV-positive patients, plasmablastic lymphoma is a rare aggressive disease which arises predominantly in men and is associated with immunodeficiency of all causes. Although its exact etiology is poorly understood, Epstein-Barr virus infection and MYC gene aberrations have been implicated in its development in both HIV-positive and HIV-negative patients. The disease typically involves extranodal sites with a predilection for the oral cavity but may occur in other locations...
November 30, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27888664/ebv-associated-but-hhv8-unrelated-double-hit-effusion-based-lymphoma
#2
Bo-Jung Chen, David Yen-Ting Chen, Chun-Chi Kuo, Shih-Sung Chuang
Effusion-based lymphoma is a rare and unique type of large B-cell lymphoma presenting in effusion without a mass lesion. It shares many clinicopathological features with primary effusion lymphoma (PEL), but is distinct from PEL by the absence of HHV8 association. Double hit lymphoma (DHL) is an aggressive B-cell lymphoma, defined by concurrent rearrangement of MYC and BCL2 or BCL6. DHL often presents as lymphadenopathy or an extranodal mass, but rarely occurs in effusion. Here we report a 61-year-old male with alcoholic cirrhosis presenting as massive ascites and left pleural effusion...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27867656/erratum-to-cardiac-obstruction-secondary-to-metastatic-invasion-a-rare-complication-of-human-herpes-virus-8-positive-plasmablastic-lymphoma-in-acquired-immunodeficiency-syndrome
#3
(no author information available yet)
[This corrects the article on p. 425 in vol. 4, PMID: 22934146.].
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27801729/richter-syndrome-with-plasmablastic-lymphoma-at-primary-diagnosis-a-case-report-with-a-review-of-the-literature
#4
Andrea Ronchi, Laura Marra, Ferdinando Frigeri, Gerardo Botti, Renato Franco, Annarosaria De Chiara
Richter syndrome (RS) is considered as the rare development of an aggressive lymphoid malignancy in a preexisting small lymphocytic lymphoma/chronic lymphocytic leukemia. The most common aggressive lymphoma developing in this setting is diffuse large B-cell lymphoma, but classical Hodgkin lymphoma and other much rarer entities such as prolymphocytic lymphoma and dendritic cell sarcoma are also described, most frequently in the progression of the disease over time. A clonal relation between the 2 neoplastic proliferations can be frequently found, whereas clonally unrelated cases are commonly considered as independent tumors, probably due to a variable combination of multiple causes, responsible independently for the 2 neoplasms...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27795651/human-immunodeficiency-virus-associated-plasmablastic-lymphoma-a-case-report
#5
Dinkar Desai, Siddharth Pandit, Shiny Jasphin, Akhil S Shetty
Non-Hodgkin's lymphoma (NHL) is the third common malignant lesion of the oral region. Plasmablastic lymphomas are rare, aggressive neoplasms occurring mostly in human immunodeficiency virus (HIV) infected individual which accounts for approximately 2.6% of all NHL. It usually presents as a diffuse growth and with diffuse pattern of histological presentation. It is very difficult to differentiate this lymphoma from other NHL. Immunohistochemical evaluation of various markers is an important criteria of the diagnostic protocol...
September 2016: Indian Journal of Dentistry
https://www.readbyqxmd.com/read/27794513/long-term-survival-of-primary-intracranial-plasmablastic-lymphoma-case-report-and-review-of-the-literature
#6
Hui Ma, Ming-Hai Wei, Hua-Min Qin, Guan-Yu Wang, Zeng-Chun Hu
BACKGROUND: Primary intracranial plasmablastic lymphoma (PIPBL) is a rare malignant tumor. CASE DESCRIPTION: We present a case of PIPBL in a 32-year-old man who complained of a progressive growing, painful mass on the right parieto-occipital part of head. Computed tomography and magnetic resonance imaging revealed a homogeneously enhanced mass with partial bone destruction. The patient underwent total resection and cranioplasty in one stage. Histopathologic examination showed large tumor cells with immunoblast-like nuclei...
October 26, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27756988/cytology-of-plasma-cell-rich-effusion-in-cases-of-plasma-cell-neoplasm
#7
Debasis Gochhait, Pranab Dey, Neelam Verma
BACKGROUND: Multiple myeloma or plasmacytoma resulting in malignant effusion is rarely described in literature. AIMS: In this paper, we have studied the seven rare cases of plasma cell infiltration in effusion fluid. MATERIALS AND METHODS: We studied six cases of pleural fluid and one case of ascetic fluid. Detailed cytological features, clinical history, bone marrow examinations, serum electrophoresis, and immunofixation data were analyzed...
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27750397/array-cgh-predicts-prognosis-in-plasma-cell-post-transplantation-lymphoproliferative-disorders
#8
Clémentine Sarkozy, Sophie Kaltenbach, Pierre Faurie, Danielle Canioni, Françoise Berger, Alexandra Traverse-Glehen, Hervé Ghesquieres, Gilles Salles, Emmanuel Bachy, Marie-Alexandra Alyanakian, Olivier Hermine, Bénédicte Neven, Elizabeth Macintyre, Serge Romana, Thierry Jo Molina, Felipe Suarez, Vahid Asnafi, Julie Bruneau
Plasma-cell post-transplantation lymphoproliferative disorder (PC-PTLD) is a rare monomorphic PTLD entity divided into plasma cell myeloma (PCM) and plasmacytoma-like lesion (PLL) PTLD. To date, there are no exhaustive published cytogenetic data on PC-PTLD. We report array-based comparative genomic hybridization (aCGH) of 10 cases of PCM and PLL-PTLD. Patients had received kidney (n=6), heart (n=2), lung (n=1) or bone marrow (n=1) transplantation. There were six men and median age at time of PTLD was 56.5 years (3-74)...
October 17, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27746876/post-transplant-lymphoproliferative-disorder-presenting-as-cd20-negative-plasmablastic-lymphoma-in-the-lung
#9
Tasneem Kaleem, Jennifer A Crozier, David M Menke, Taimur Sher
Post-transplant lymphoproliferative disorders (PTLD) are a serious complication of transplantation with a high mortality. Most PTLD present within the first year of transplantation and are associated with Epstein-Barr virus (EBV) infection. Plasmablastic lymphoma (PBL) is a rare but aggressive disease originally described in patients with HIV, presenting most commonly in the jaw and oral mucosa. To our knowledge, this is the first case of PBL presenting as PTLD of the lung in a HIV and EBV negative patient...
September 5, 2016: Rare Tumors
https://www.readbyqxmd.com/read/27740969/alk-positive-large-b-cell-lymphoma-a-clinicopathologic-study-of-26-cases-with-review-of-additional-108-cases-in-the-literature
#10
Zenggang Pan, Shimin Hu, Min Li, Yi Zhou, Young S Kim, Vishnu Reddy, Jennifer N Sanmann, Lynette M Smith, Mingyi Chen, Zifen Gao, Huan-You Wang, Ji Yuan
Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK LBCL) is a rare, aggressive subtype of diffuse large B-cell lymphoma with characteristic ALK rearrangements. Diagnosis of ALK LBCL can be challenging because of its rarity, unique morphologic characteristics, and unusual immunophenotypic features, which significantly overlap with other hematologic and nonhematologic neoplasms. The purpose of this study is to further explore the clinicopathologic features of ALK LBCL to ensure the awareness and accurate diagnosis of this entity...
October 12, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27738277/a-rare-presentation-of-plasmablastic-lymphoma-as-cutaneous-nodules-in-an-immunocompromised-patient
#11
Selvin Sundar Raj Mani, Thomas Kodiatte, Manjeera Jagannati
Plasmablastic lymphoma is a rare entity accounting for around 2.7% of all AIDS-related lymphomas. The oral cavity and gastrointestinal tract are the most common sites involved. We report a case of a 34-year-old HIV-positive woman with a rare presentation of cutaneous nodules all over the body. Due to overwhelming tumour burden, she developed tumour lysis syndrome during her hospital stay and succumbed to the illness.
October 13, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27735156/primary-maxillary-sinus-plasmablastic-lymphoma-in-hiv-aids
#12
Anita Basavaraj, Manasi Kadam, D B Kadam
Classically, the HIV/AIDS-related lymphomas are of the B cell type and involve the central nervous system and the abdominal cavity. Primary maxillary sinus lymphoma is rare. Plasmablastic lymphoma (PBL) is an aggressive form of non-Hodgkinvs lymphoma, and is extremely rare. Here we present a case of plasmablastic lymphoma with primary site being maxillary sinus, a rare location.
May 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27719718/-clinical-features-and-outcomes-analysis-of-9-cases-of-hiv-negtive-plasmablastic-lymphoma
#13
L Gui, X H He, P Liu, J L Yang, Y Qin, S Y Zhou, S Yang, C G Zhang, Y K Shi
Objective: To evaluate the clinical features and outcomes of HIV-negtive plasmablastic lymphoma (PBL). Methods: Nine patients with HIV-negtive PBL were diagnosed and treated between January 2006 and January 2016. The clinical and follow-up data were analyzed retrospectively. Results: The median age was 56 years (range 30-77 years) with a male-to-female ratio of 2∶1. Nobody had underlying diseases associated with immunosuppression. Primary extra nodal diseases were observed in 7 cases and only 1 patient had oral involvement...
September 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27687004/plasmablastic-lymphoma-phenotype-is-determined-by-genetic-alterations-in-myc-and-prdm1
#14
Santiago Montes-Moreno, Nerea Martinez-Magunacelaya, Tomás Zecchini-Barrese, Sonia Gonzalez de Villambrosía, Emma Linares, Tamara Ranchal, María Rodriguez-Pinilla, Ana Batlle, Laura Cereceda-Company, Jose Bernardo Revert-Arce, Carmen Almaraz, Miguel A Piris
Plasmablastic lymphoma is an uncommon aggressive non-Hodgkin B-cell lymphoma type defined as a high-grade large B-cell neoplasm with plasma cell phenotype. Genetic alterations in MYC have been found in a proportion (~60%) of plasmablastic lymphoma cases and lead to MYC-protein overexpression. Here, we performed a genetic and expression profile of 36 plasmablastic lymphoma cases and demonstrate that MYC overexpression is not restricted to MYC-translocated (46%) or MYC-amplified cases (11%). Furthermore, we demonstrate that recurrent somatic mutations in PRDM1 are found in 50% of plasmablastic lymphoma cases (8 of 16 cases evaluated)...
September 30, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27684979/plasmablastic-lymphoma-a-review-of-clinicopathologic-features-and-differential-diagnosis
#15
Charles M Harmon, Lauren B Smith
Plasmablastic lymphoma (PBL) is a challenging diagnosis given its rarity and lack of expression of markers that are usually used by pathologists in establishing hematopoietic lineage. However, knowledge of the characteristic clinical setting, sites of involvement, and morphologic features of plasmablastic lymphoma can aid in the correct diagnosis of a suspected large cell lymphoma that is negative for B-cell- and T-cell-specific antigens. Herein, we review the clinical and pathologic features of plasmablastic lymphoma with an emphasis on the differential diagnosis of hematolymphoid neoplasms with immunoblastic morphology and/or evidence of plasmacytic differentiation by immunophenotype...
October 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27683629/recent-insights-in-the-pathogenesis-of-post-transplantation-lymphoproliferative-disorders
#16
REVIEW
Julie Morscio, Thomas Tousseyn
Post-transplant lymphoproliferative disorder (PTLD) is an aggressive complication of solid organ and hematopoietic stem cell transplantation that arises in up to 20% of transplant recipients. Infection or reactivation of the Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, in combination with chronic immunosuppression are considered as the main predisposing factors, however insight in PTLD biology is fragmentary. The study of PTLD is complicated by its morphological heterogeneity and the lack of prospective trials, which also impede treatment optimization...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27617520/plasmablastic-lymphoma-an-atypical-cutaneous-presentation-of-a-rare-entity
#17
Fernando Mota, Bruno Mesquita, S Carvalho, André Coelho, Glória Velho, Margarida Lima, Manuela Selores
Plasmablastic lymphoma is a very rare B-cell lymphoma typically associated with immunosuppression: It occurs primarily in the oral cavity, although some cases were reported in other organs and tissues.To date, only 10 cases of primary cutaneous plasmablastic lymphoma have been described. Clinically, primary cutaneous plasmablastic lymphoma presents as non-specific cutaneous lesions (purple nodules, erythematous infiltrated plaques). In previously described cases, as in this case, histology and immunohistochemistry are required to make the diagnosis...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27604616/clinical-and-pathological-aspects-of-human-immunodeficiency-virus-associated-plasmablastic-lymphoma-analysis-of-24-cases
#18
Yusuke Koizumi, Tomoko Uehira, Yasunori Ota, Yoshihiko Ogawa, Keishiro Yajima, Junko Tanuma, Mihoko Yotsumoto, Shotaro Hagiwara, Satoshi Ikegaya, Dai Watanabe, Hitoshi Minamiguchi, Keiko Hodohara, Kenta Murotani, Hiroshige Mikamo, Hideho Wada, Atsushi Ajisawa, Takuma Shirasaka, Hirokazu Nagai, Yoshinori Kodama, Tsunekazu Hishima, Makoto Mochizuki, Harutaka Katano, Seiji Okada
Plasmablastic lymphoma (PBL) is a rare AIDS-related malignancy with a poor prognosis. Little is known about this entity, and no standard treatment regimen has been defined. To establish an adequate treatment strategy, we investigated 24 cases of PBL arising in human immunodeficiency virus-positive individuals. Most of the patients were in the AIDS stage, with a median CD4 count of 67.5/µL. Lymph nodes (58 %), gastrointestinal tract (42 %), bone marrow (39 %), oral cavity (38 %), and CNS (18 %) were the most commonly involved sites...
September 7, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27579749/primary-cutaneous-plasmablastic-lymphoma-revealing-clinically-unsuspected-hiv-infection
#19
Silvio Alencar Marques, Luciana P Fernandes Abbade, Marcelo Massaki Guiotoku, Mariangela Esther Alencar Marques
Plasmablastic lymphoma is a rare subtype of diffuse large B-cell lymphoma more frequently diagnosed in immunosuppressed patients, mainly HIV-infected. Primary cutaneous plasmablastic lymphoma is extremely rare, and in this patient it was the first clinical manifestation of unsuspected HIV-infection.
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27576534/-plasmablastic-lymphoma
#20
Rubén Fernández-Álvarez, Juan-Manuel Sancho, Josep-María Ribera
Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin lymphoma that commonly occurs in human immunodeficiency virus (HIV)-positive individuals, and affects oral sites. Occasionally, it has been described in HIV-negative patients and involving non-oral sites. Pathologically, PBL is a high-grade B-cell lymphoma that displays the immunophenotype of a terminally differentiated B-lymphocyte with loss of B-cell markers (CD20) and expression of plasma-cell antigens. Epstein-Barr virus infection and MYC rearrangements are frequently observed...
November 4, 2016: Medicina Clínica
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