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CV risk

Alaa Atamna, Gida Ayada, Amit Akirov, Tzippy Shochat, Jihad Bishara, Avishay Elis
Background: Limited data are available regarding the association between glucose levels variability (GV) and outcomes of patients hospitalized with acute infectious diseases. Objectives: To determine the association between GV and bacteremia, length of stay (LOS) and mortality. Methods: A retrospective study of patients hospitalized in departments of medicine with respiratory tract, urinary tract and skin and soft tissue infections during 2011-2017...
October 16, 2018: QJM: Monthly Journal of the Association of Physicians
Bharath Ambale-Venkatesh, Chia-Ying Liu, Yuan-Chang Liu, Sirisha Donekal, Yoshiaki Ohyama, Ravi K Sharma, Colin O Wu, Wendy S Post, Gregory W Hundley, David A Bluemke, João A C Lima
Aims: We used contrast-enhanced cardiac magnetic resonance (CMR) to evaluate differences in myocardial fibrosis measured at the year-10 examination between participants with and without cardiovascular (CV) events accrued in a large population based study over the preceding 10-year follow-up period in this retrospective study. Methods and results: The MESA study enrolled 6814 participants free of CV disease at baseline (2000-2002). We included MESA participants who underwent contrast-enhanced CMR at the MESA year-10 exam (N = 1840)...
October 16, 2018: European Heart Journal Cardiovascular Imaging
Lucía Ramos, Jorge Novo, Noelia Barreira, José Rouco, Manuel G Penedo, Marcos Ortega
Cardiovascular diseases (CVDs) are the leading cause of death throughout the world. The total risk of developing CVD is determined by the combined effect of different cardiovascular risk factors (e.g., diabetes, raised blood pressure, unhealthy diet, tobacco use, stress, etc.) that commonly coexist and act multiplicatively. Most CVDs can be prevented by an early identification of the highest risk factors and an appropriate treatment. The stratification of cardiovascular risk factors involves a wide range of parameters and tests that specialists use in their clinical practice...
September 26, 2018: Journal of Visualized Experiments: JoVE
Balbir Singh, Shu Zhang, Chi-Keong Ching, Dejia Huang, Yen-Bin Liu, Diego A Rodriguez, Azlan Hussin, Young-Hoon Kim, Alexandr Robertovich Chasnoits, Jeffrey Cerkvenik, Katy A Muckala, Alan Cheng
BACKGROUND: Despite available evidence that ICDs reduce all-cause mortality for those at increased risk for sudden cardiac death, utilization of ICDs is low, especially in developing countries. OBJECTIVE: The objective of this analysis is to summarize reasons for ICD or CRT-D implant refusal for Improve SCA patients in developing countries. METHODS: PP and secondary prevention (SP) patients from countries where ICD use is low were enrolled...
October 15, 2018: Pacing and Clinical Electrophysiology: PACE
Stephan R Seibert, David P Schladt, Baolin Wu, Weihua Guan, Casey Dorr, Rory P Remmel, Arthur J Matas, Roslyn B Mannon, Ajay K Israni, William S Oetting, Pamala A Jacobson
BACKGROUND: Suboptimal immunosuppression after kidney transplantation contributes to toxicity and loss of efficacy. Little is known regarding the impact of intra-patient variability of tacrolimus (TAC) doses and troughs in the early post-transplant period or the influence of genetic variants on variability. METHODS: Coefficients of variation (CV) of TAC troughs and doses of 1226 European American (EA) and 246 African American (AA) adult recipients enrolled in DeKAF Genomics were compared for association with acute rejection and graft failure...
October 14, 2018: Clinical Transplantation
Miha Tibaut, Martin Caprnda, Peter Kubatka, Andreja Sinkovič, Vanda Valentova, Slavomira Filipova, Katarina Gazdikova, Ludovit Gaspar, Ioana Mozos, Emmanuel E Egom, Luis Rodrigo, Peter Kruzliak, Daniel Petrovič
This is Part 2 of a two-part review summarising current knowledge on biomarkers of atherosclerosis. Part 1 addressed serological biomarkers. Here, in part 2 we address genetic and imaging markers, and other developments in predicting risk. Further improvements in risk stratification are expected with the addition of genetic risk scores. In addition to single nucleotide polymorphisms (SNPs), recent advances in epigenetics offer DNA methylation profiles, histone chemical modifications, and micro-RNAs as other promising indicators of atherosclerosis...
September 29, 2018: Heart, Lung & Circulation
Panagiotis Anagnostis, Pavlos Siolos, Dimitrios Krikidis, Dimitrios G Goulis, John C Stevenson
BACKGROUND: Familial hypercholesterolaemia (FH) is a genetically determined lipid disorder, affecting 1 per 200-500 individuals in the general population. It is significantly and independently associated with increased risk of cardiovascular disease (CVD), although it remains still an underrecognized and undertreated disease. Lipoprotein (a) [Lp(a)] is a low-density-lipoprotein (LDL)-like molecule, containing an additional protein, apolipoprotein (a). OBJECTIVE: This review aims to present and discuss available data on the role of Lp(a) in patients with FH, in terms of its potential augmentation of CVD risk...
October 10, 2018: Current Pharmaceutical Design
Vasilios Papademetriou, Konstantinos Stavropoulos, Christodoulos Papadopoulos, Konstantinos Koutsampasopoulos, Kiriakos Dimitriadis, Kostas Tsioufis
BACKGROUND: Familial hypercholesterolemia (FH) is an inherited autosomal dominant disorder that is characterized by substantially increased low-density lipoprotein cholesterol (LDL-C) levels. Patients with FH have a significantly higher risk for cardiovascular (CV) events, and the timely reduction of LDL-C is of paramount importance to ameliorate the risk for CV disease. Among the available lipid-lowering therapies, the novel proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have emerged as a very promising class of drugs for the management of such patients...
October 10, 2018: Current Pharmaceutical Design
Michał Pluta, Tomasz Klocek, Łukasz J Krzych
BACKGROUND: The red blood cell distribution width index (RDW) is one of several parameters routinely analysed in peripheral blood counts. The aim of the study was to assess the usefulness of RDW in the prediction of in-hospital mortality in patients undergoing high-risk gastroenterological surgery. METHODS: Prospective observation covered 229 patients who underwent surgery, for whom the risk of cardiovascular complications was high due to the type of procedure. The patient's individual risk was assessed using the criteria of the American Society of Anesthesiologists (ASA-PS)...
October 14, 2018: Anaesthesiology Intensive Therapy
Manuel Almendro-Delia, Iván J Núñez-Gil, Manuel Lobo, Mireia Andrés, Oscar Vedia, Alessandro Sionis, Ana Martin-García, María Cruz Aguilera, Eduardo Pereyra, Irene Martín de Miguel, José A Linares Vicente, Miguel Corbí-Pascual, Xavier Bosch, Oscar Fabregat Andrés, Alejandro Sánchez Grande Flecha, Alberto Pérez-Castellanos, Javier López Pais, Manuel De Mora Martín, Juan María Escudier Villa, Roberto Martín Asenjo, Marta Guillen Marzo, Ferrán Rueda Sobella, Álvaro Aceña, José María García Acuña, Juan C García-Rubira
OBJECTIVES: This study sought to describe the incidence, determinants, and prognostic impact of cardiogenic shock (CS) in takotsubo syndrome (TTS). BACKGROUND: TTS can be associated with severe hemodynamic instability. The prognostic implication of CS has not been well characterized in large studies of TTS. METHODS: We analyzed patients with a definitive TTS diagnosis (modified Mayo criteria) who were recruited for the National RETAKO (Registry on Takotsubo Syndrome) trial from 2003 to 2016...
October 4, 2018: JACC. Heart Failure
Muhammad Usman, Clare L Gillies, Kamlesh Khunti, Melanie J Davies
AIMS: The effect of intensive glycaemic control, blood pressure control and lipid levels control alone or as part of a multifactorial intervention has not been fully evaluated. We aimed to estimate the effects of more intensive interventions, compared with standard care, on risk factor control and cardiovascular outcomes in people with type 2 diabetes and microalbuminuria. METHODS: We searched MEDLINE, Embase and the Cochrane library without language restrictions from inception to August 10, 2018...
October 9, 2018: Diabetes Research and Clinical Practice
Zekai Chen, Shouling Wu, Jianhuan Huang, Jinhuan Yuan, Haojia Chen, Youren Chen
BACKGROUND: The prevalence of pre-diabetes has been epidemic globally and pre-diabetes is often accompanied with metabolic syndrome (MS). But the association between MS and cardiovascular (CV) risk among pre-diabetic individuals in China remains unknown. OBJECTIVE: This study aimed to identify the relationship of MS with CV risk in Chinese adults with prediabetes. METHODS: Altogether 19,464 participants with pre-diabetes were enrolled at baseline and were followed up prospectively...
October 12, 2018: Journal of Diabetes Investigation
Bryan G Schwartz, Robert A Kloner, Morteza Naghavi
Inability to predict short-term cardiovascular (CV) events and take immediate preemptive actions has long been the Achilles heel of cardiology. However, certain triggers of these events have come to light. Although these triggers are nonspecific and are part of normal life, studying their temporal relationship with the onset of CV events provides an opportunity to alert high-risk atherosclerotic patients who may be most vulnerable to such triggers, the "vulnerable patient". Herein, we review the literature and shed light on the epidemiology and underlying pathophysiology of different triggers...
September 13, 2018: American Journal of Cardiology
Lei Wang, Xulei Huang, Dorothy Jingwen Lim, Anna Karen Carrasco Laserna, Sam Fong Yau Li
The flame retardant triphenyl phosphate (TPhP) has been widely detected in surface waters. Yet, little information is known regarding its impact on microalgae. We investigated the uptake and toxicity of TPhP on two freshwater microalgae Chlorella vulgaris (CV) and Scenedesmus obliquus (SO) after exposure to 10 μg/l-10 mg/l for 5 days. The presence of microalgae significantly enhanced TPhP degradation, with the final concentrations dropped to 5.5-35.1% of the original concentrations. Most of the medium TPhP were sorbed and transformed by microalgae in just one day...
February 10, 2019: Science of the Total Environment
Luca Navarini, Domenico Paolo Emanuele Margiotta, Francesco Caso, Damiano Currado, Marco Tasso, Silvia Angeletti, Massimo Ciccozzi, Raffaele Scarpa, Antonella Afeltra, Luisa Costa
INTRODUCTION: In patients with psoriatic arthritis (PsA) an increased cardiovascular (CV) risk has been observed. Recently, a EULAR taskforce suggested to use a multiplication by the factor of 1.5 of CV risk algorithms in patients with inflammatory arthritis. This study aims to evaluate the performance of five original and adapted according to EULAR recommendations CV risk algorithms in PsA: SCORE, CUORE, Framingham Risk Score (FRS), QRISK2, and Reynold's Risk Score (RRS). METHODS: Prospectively collected data from two Italian cohorts were used...
2018: PloS One
Jingyi Lu, Xiaojing Ma, Lei Zhang, Yifei Mo, Lingwen Ying, Wei Lu, Wei Zhu, Yuqian Bao, Jian Zhou
OBJECTIVE: The relationship between glycaemic variability (GV) and diabetic complications has gained much interest and remains under debate. Moreover, the association of GV with diabetic complications has not been examined in latent autoimmune diabetes of the adult (LADA). Therefore, we evaluated the relationships among several metrics of GV with diabetic retinopathy (DR) in patients with LADA and type 2 diabetes (T2DM). METHODS: A total of 192 patients with LADA and 2927 patients with T2DM were enrolled...
October 10, 2018: Journal of Diabetes Investigation
Sang-Woong Choi, Hyungseop Kim, In-Cheol Kim, Cheol-Hyun Lee, Jongmin Hwang, Hyoung-Seob Park, Yun-Kyeong Cho, Hyuck-Jun Yoon, Chang-Wook Nam, Seongwook Han, Seung-Ho Hur
PURPOSE: Ultrasonographic contrast enhancement of carotid plaque (CECP) has been used to detect neovascularization of vasa vasorum and plaque. However, it is uncertain whether CECP can provide risk stratification of coronary artery disease (CAD). This study aimed to evaluate the relationship between CECP and manifestations of acute coronary syndrome (ACS) in established CAD patients and to explore the prognostic implication of CECP for cardiovascular (CV) clinical outcomes. METHODS: A medical record review revealed that contrast-enhanced ultrasonography was performed to evaluate carotid atherosclerosis in 209 coronary artery-stented and 105 non-stented patients...
September 2018: Journal of Clinical Ultrasound: JCU
Michael P Bancks, Mercedes R Carnethon, David R Jacobs, Lenore J Launer, Jared P Reis, Pamela J Schreiner, Ravi V Shah, Stephen Sidney, Kristine Yaffe, Yuichiro Yano, Norrina B Allen
OBJECTIVE: To determine whether intraindividual variability in fasting glucose (FG) below the threshold of diabetes is associated with cognitive function in middle adulthood beyond increasing FG. RESEARCH DESIGN AND METHODS: We studied 3,307 CARDIA (Coronary Artery Risk Development Study in Young Adults) participants (age range 18-30 years; 1985-1986) at baseline and calculated two measures of long-term glucose variability: the coefficient of variation about the mean FG (CV-FG) and the absolute difference between successive FG measurements [average real variability (ARV-FG)] before the onset of diabetes over 25 and 30 years of follow-up...
October 10, 2018: Diabetes Care
Lingling Xu, Xiaopu Lin, Meiping Guan, Yingshan Liu
INTRODUCTION: Early detection of diabetic peripheral neuropathy (DPN) is critical in patients with type 2 diabetes mellitus (T2DM) due to the lack of targeted therapy for DPN. We have investigated the relationship between different stages of diabetic nephropathy and DPN in an attempt to elucidate whether albuminuria can be used as an early warning signal of DPN progression. METHODS: A total of 217 T2DM patients who met the inclusion criteria were recruited from the Department of Endocrinology, Nanfang Hospital between January 2016 and June 2016...
October 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Adiel Roitman, Ilan Ben-Zvi, Liran Mendel, Avi Livneh
OBJECTIVES: Patients, suffering from inflammatory disorders, are at an increased risk to develop cardiovascular disease (CVD). Here, we examine whether in familial Mediterranean fever (FMF), a model of inflammatory diseases, inflammation also increases the risk to develop cardiovascular (CV) disease. METHODS: To explore the role of inflammation in the occurrence of CVD in FMF, we identified all FMF patients ≤55 years old with CVD, admitted to our center over a 15-year period...
September 27, 2018: Clinical and Experimental Rheumatology
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