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Cardiovascular diagnosis

Kelly A Aschbrenner, John A Naslund, Amy A Gorin, Kim T Mueser, Emily A Scherer, Mark Viron, Allison Kinney, Stephen J Bartels
BACKGROUND: Individuals with serious mental illness (SMI) such as schizophrenia and bipolar disorder face a higher risk of early death due to cardiovascular disease and other preventable chronic illnesses. Young adulthood is a critical window of development for lifestyle interventions to improve the long-term health and quality of life in this population. Fit Forward is an NIH-funded randomized clinical trial examining the effectiveness of a group lifestyle intervention (PeerFIT) enhanced with mobile health technology compared to one-on-one mobile lifestyle coaching with Basic Education in fitness and nutrition supported by a wearable Activity Tracking device (BEAT) in achieving clinically significant weight loss and improved cardiorespiratory fitness in young adults with SMI...
October 11, 2018: Contemporary Clinical Trials
Thibaud Chazal, Raphael Lhote, Grégoire Rey, Julien Haroche, Mireille Eb, Zahir Amoura, Fleur Cohen Aubart
OBJECTIVES: Giant---cell arteritis (GCA) is a large vessel vasculitis. Data regarding mortality are controversial. We describe the mortality data of the French death certificates for the period of 2005 to 2014. METHODS: Using multiple---cause---of---death (MCOD) analysis, we calculated age---adjusted mortality rates for GCA, examined differences in mortality rates according to age and gender and analyzed the underlying causes of death (UCD). Results We analyzed 4628 death certificates listing a diagnosis of GCA as UCD or non-underlying cause of death (NUCD)...
October 11, 2018: Autoimmunity Reviews
Manuel Almendro-Delia, Iván J Núñez-Gil, Manuel Lobo, Mireia Andrés, Oscar Vedia, Alessandro Sionis, Ana Martin-García, María Cruz Aguilera, Eduardo Pereyra, Irene Martín de Miguel, José A Linares Vicente, Miguel Corbí-Pascual, Xavier Bosch, Oscar Fabregat Andrés, Alejandro Sánchez Grande Flecha, Alberto Pérez-Castellanos, Javier López Pais, Manuel De Mora Martín, Juan María Escudier Villa, Roberto Martín Asenjo, Marta Guillen Marzo, Ferrán Rueda Sobella, Álvaro Aceña, José María García Acuña, Juan C García-Rubira
OBJECTIVES: This study sought to describe the incidence, determinants, and prognostic impact of cardiogenic shock (CS) in takotsubo syndrome (TTS). BACKGROUND: TTS can be associated with severe hemodynamic instability. The prognostic implication of CS has not been well characterized in large studies of TTS. METHODS: We analyzed patients with a definitive TTS diagnosis (modified Mayo criteria) who were recruited for the National RETAKO (Registry on Takotsubo Syndrome) trial from 2003 to 2016...
October 4, 2018: JACC. Heart Failure
Ted Boozalis, Sridevi Devaraj, Olaoluwa O Okusaga
High prevalence of obesity in individuals with schizophrenia, associated with metabolic syndrome, leads to high rate of premature deaths from cardiovascular disease (CVD) in this population. Body mass index (BMI) and C-reactive protein (CRP) are correlated in the general population but this relationship has not been fully elucidated in patients with schizophrenia. We aimed to evaluate the correlation between BMI and CRP while relating both variables to plasma lipids in patients with schizophrenia. BMI, fasting high sensitivity CRP (hs-CRP), cotinine, and lipids were measured in 106 patients with schizophrenia (diagnosis confirmed with MINI)...
October 12, 2018: Psychiatric Quarterly
Allan K Grill, Scott Brimble
OBJECTIVE: To help primary care providers, both family physicians and nurse practitioners, identify, detect, and manage patients with and at risk of chronic kidney disease (CKD), as well as outline criteria for appropriate referral to nephrology. SOURCES OF INFORMATION: Published guidelines on the topic of CKD and its comorbidities were reviewed. A MEDLINE search was conducted using the MeSH terms chronic renal insufficiency, family practice, and primary health care ...
October 2018: Canadian Family Physician Médecin de Famille Canadien
Wenyue Wang, Xu Li, Xiuhua Yao, Xiuli Cheng, Yu Zhu
Cerebral infarction (CI) is associated with high rates of disability, mortality, and death in China, but its mechanism is unclear. Therefore, early diagnosis of CI and determining its mechanism are very important. Intestinal microecology is thought to be related to cardiovascular and cerebrovascular diseases. We hypothesized that intestinal microecology is also related to CI and that the intestinal microecology in the stool of CI patients differs from that in healthy people.Fecal samples of healthy subjects and CI patient (all n = 10) and we investigated the intestinal microecology of CI patient and healthy people stool by 16 seconds sequencing and analyzed relative abundance and diversity of microorganisms by unweighted pair-group method with arithmetic mean analysis (UPGMA) and principal co-ordinates analysis (PCoA)...
October 2018: Medicine (Baltimore)
Simona Portaro, Antonino Naro, Vincenzo Cimino, Giuseppa Maresca, Francesco Corallo, Rosa Morabito, Rocco Salvatore Calabrò
INTRODUCTION: Transient global amnesia (TGA) is characterized by a sudden onset of anterograde and retrograde amnesia, sometimes associated with mild subclinical neuropsychological deficits and vegetative symptoms, lasting for days after the episode. Migraine history, cardiovascular risk factors, and emotional stress are considered possible risk factors. TGA usually occurs during the seventh decade of life, that is, when risk factors and concomitant pathologies have a higher incidence...
October 2018: Medicine (Baltimore)
Pingsen Zhao, Heming Wu, Zhixiong Zhong, Qifeng Zhang, Wei Zhong, Bin Li, Cunren Li, Zhidong Liu, Min Yang
Acute myocardial infarction (AMI) is the most serious type of coronary atherosclerotic diseases. The incidence of AMI in some countries increases year by year, and shows younger trend. Some study indicated that abnormal expression of lncRNAs was closely related to cardiovascular disease. The aim of this study was to examine the lncRNA expression profiles in peripheral blood mononuclear cells (PBMCs) of patients with AMI through controlled studies.In the present study, we examined the lncRNA and mRNA expression profiles in 8 patients with AMI, with 7 NCA (noncoronary artery) subjects as controls using RNA sequencing protocol (RNA-seq) on the Illumina HiSeq 4000 platform...
October 2018: Medicine (Baltimore)
Juan Li, Liangliang Wang, Qian Wang, Zhaoqin Xin, Yilin Liu, Qinghua Zhao
Hypersensitive C-reactive protein (hs-CRP) is reported to be significant risk indicators not only for the development of cardiovascular disease, but also for the development or progression of type 2 diabetes. The objective of this study was to analyze the significance of hs-CRP in type 2 diabetes mellitus (T2DM) combined with acute myocardial infarction (AMI).Fifty patients with both T2DM and AMI, 50 patients with T2DM alone, and 50 healthy subjects (control group) were selected.Operating characteristic (ROC) analysis revealed that the sensitivity, specificity, accuracy, and critical value in the diagnosis of T2DM combined with AMI using hs-CRP level were 84...
October 2018: Medicine (Baltimore)
Scott R Steele, Justin T Brady, Zhun Cao, Dorothy L Baumer, Scott B Robinson, H Keri Yang, Conor P Delaney
BACKGROUND: Postoperative ileus is a significant complication after bowel resection surgeries. Alvimopan is the only US Food and Drug Administration-approved therapy for accelerating the return of bowel function after large- and small-bowel resection. OBJECTIVE: The purpose of this study was to estimate the healthcare use and in-hospital morbidities associated with on-label use of alvimopan in patients undergoing bowel resection surgeries. DESIGN: A retrospective observational propensity-matched cohort study was conducted using a large hospital administrative database...
October 11, 2018: Diseases of the Colon and Rectum
Kaustubha D Patil, Joseph E Marine
Minimally-invasive percutaneous cardiovascular procedures have dramatically improved the diagnosis and treatment of cardiovascular disease over the last three decades. This article is protected by copyright. All rights reserved.
October 12, 2018: Journal of Cardiovascular Electrophysiology
Yuanzi Ye, Petr Otahal, Thomas H Marwick, Karen E Wills, Amanda L Neil, Alison J Venn
BACKGROUND: With improved cancer survivorship, cardiovascular disease (CVD) and other noncancer events compete with cancer as the underlying cause of death, but the risks of mortality in competing-risk settings have not been well characterized. METHODS: The authors identified 21,637 individuals who had a first cancer registered between 2006 and 2013, with follow-up to 2015, in the Australian population-based Tasmanian Cancer Registry. The cumulative incidence of deaths from specific competing events was assessed in competing-risk analyses...
October 12, 2018: Cancer
Andrés M Pineda, Todd L Kiefer
PURPOSE OF REVIEW: The optimal treatment for asymptomatic patients with severe aortic valve stenosis (AS) is not clearly known. Here, we review the available data on the management of such patients. RECENT FINDINGS: Half of patients with severe AS are asymptomatic at the time of diagnosis, and are at risk for adverse events, including sudden cardiac death. A significant proportion of these patients develop AS-related symptoms within 1 or 2 years. Clinical and echocardiographic characteristics are predictors of poor outcomes and can guide treatment decisions...
October 11, 2018: Current Cardiology Reports
Rodrigo Alonso, Leopoldo Perez de Isla, Ovidio Muñiz-Grijalvo, Jose Luis Diaz-Diaz, Pedro Mata
Familial hypercholesterolaemia is the most common monogenic disorder associated with premature coronary artery disease. Mutations are most frequently found in the LDL receptor gene. Clinical criteria can be used to make the diagnosis; however, genetic testing will confirm the disorder and is very useful for cascade screening. Early identification and adequate treatment can improve prognosis, reducing negative clinical cardiovascular outcomes. Patients with familial hypercholesterolaemia are considered at high cardiovascular risk and the treatment target is LDL cholesterol <2...
August 2018: European Cardiology
Rachel E Luehrs, John D Newell, Alejandro P Comellas, Eric A Hoffman, Kelsey Warner, Anna Croghan, Lyndsey E DuBose, Peggy Nopoulos, Vince Magnotta, Stephan Arndt, Gary L Pierce, Karin F Hoth
Early stages of chronic obstructive pulmonary disease (COPD) are characterized by the loss and narrowing of terminal bronchioles in the lung resulting in 'air-trapping,' often occurring before overt emphysema manifests. Individuals with an airway-predominant phenotype of COPD display extensive lung air-trapping and are at greater cardiovascular disease (CVD) risk than COPD patients with an emphysema-predominant phenotype. We hypothesized that the degree of computed tomography (CT)-quantified lung air-trapping would be associated with greater aortic and carotid artery stiffness and lower endothelial function, known biomarkers of CVD risk...
October 11, 2018: Journal of Applied Physiology
Jeanette F Winther, Smita Bhatia, Luise Cederkvist, Thorgerdur Gudmundsdottir, Laura Madanat-Harjuoja, Laufey Tryggvadottir, Finn Wesenberg, Henrik Hasle, Anna Sällfors Holmqvist
BACKGROUND: Childhood cancer survivors have an increased risk of cardiovascular disease (CVD) and diabetes mellitus. Because diabetes is a potentially modifiable risk factor for CVD in the general population, it is important to understand how diabetes affects the risk of CVD among childhood cancer survivors. METHODS: This study examined the risk of CVD among survivors with diabetes and 142,742 population comparison subjects. From the national cancer registries of the 5 Nordic countries, 29,324 one-year survivors of cancer diagnosed before the age of 20 years between 1968 and 2008 were identified...
October 11, 2018: Cancer
Omar Yaxmehen Bello-Chavolla, Anuar Kuri-García, Monserratte Ríos-Ríos, Arsenio Vargas-Vázquez, Jorge Eduardo Cortés-Arroyo, Gabriela Tapia-González, Ivette Cruz-Bautista, Carlos Alberto Aguilar-Salinas
Familial combined hyperlipidemia (FCHL) is the most prevalent primary dyslipidemia; however, it frequently remains undiagnosed and its precise definition is a subject of controversy. FCHL is characterized by fluctuations in serum lipid concentrations and may present as mixed hyperlipidemia, isolated hypercholesterolemia, hypertriglyceridemia, or as a normal serum lipid profile in combination with abnormally elevated levels of apolipoprotein B. FCHL is an oligogenic primary lipid disorder, which can occur due to the interaction of several contributing variants and mutations along with environmental triggers...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Matilda Florentin, Michael S Kostapanos, Moses S Elisaf, Evangelos N Liberopoulos
BACKGROUND: Familial hypercholesterolemia (FH) is the most common metabolic genetic disorder, with around 13 million people worldwide having the disease. However, FH is globally underdiagnosed and undertreated, while the vast majority of those treated do not achieve treatment goals. OBJECTIVE: This review aims to clarify how to identify patients with FH. METHODS: We performed a comprehensive search of the literature to identify available data...
October 8, 2018: Current Pharmaceutical Design
Margus Viigimaa, Silver Heinsar, Dragan Lovic, Alexandra Katsimardou, Alexia Piperidou, Davit Duishvili
BACKGROUND: Familial hypercholesterolaemia (FH) is an autosomal-dominant genetic disease andrepresents the most common genetic disorder: heterozygous 1/250 births, homozygous 1/300,000 births. FH is characterized by high to very high low density lipoprotein cholesterol (LDL-C), which is the main cause of increased incidence of premature atherosclerotic cardiovascular disease (CVD) or aortic stenosis. OBJECTIVE: The aim of the review was to investigate the pathogenesis and the pathophysiology of FH...
October 8, 2018: Current Pharmaceutical Design
Nicholas G Kounis, Gianfranco Cervellin, Ioanna Koniari, Laura Bonfanti, Periklis Dousdampanis, Nikolaos Charokopos, Stelios F Assimakopoulos, Stavros K Kakkos, Ioannis G Ntouvas, George D Soufras, Ioannis Tsolakis
The first reported human anaphylactic death is considered to be the Pharaoh Menes death, caused by a wasp sting. Currently, anaphylactic cardiovascular events represent one of most frequent medical emergencies. Rapid diagnosis, prompt and appropriate treatment can be life saving. The main concept beyond anaphylaxis lies to myocardial damage and ventricular dysfunction, thus resulting in cardiovascular collapse. Cardiac output depression due to coronary hypoperfusion from systemic vasodilation, leakage of plasma and volume loss due to increased vascular permeability, as well as reduced venous return, are regarded as the main causes of cardiovascular collapse...
September 2018: Annals of Translational Medicine
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