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Cardiovascular diagnosis

Eike Sebastian Debus, Levente Kriston, Thea Schwaneberg, Sandra Hischke, Henrik Christian Rieß, Martin Härter, Ursula Marschall, Hannes Federrath, Christian-Alexander Behrendt
BACKGROUND: Atherosclerotic disease of the lower extremity arteries (PAD) remains a significant burden on global healthcare systems with increasing prevalence. Various guidelines on the diagnosis and treatment of patients with PAD are available but they often lack a sufficient evidence base for high-grade recommendations since randomized and controlled trials (RCT) remain rare or are frequently subject to conflicts of interest. This registry trial aims to evaluate the outcomes of catheter-based endovascular revascularisations vs...
August 16, 2018: VASA. Zeitschrift Für Gefässkrankheiten
Devon J Boyne, Alexis T Mickle, Darren R Brenner, Christine M Friedenreich, Winson Y Cheung, Karen L Tang, Todd A Wilson, Diane L Lorenzetti, Matthew T James, Paul E Ronksley, Doreen M Rabi
Cardiovascular disease has been identified as one of the late complications of cancer therapy. The purpose of this study was to quantify the long-term risk of cardiovascular mortality among lymphoma survivors relative to that of the general population. A systematic review and meta-analysis were conducted. Articles were identified in November 2016 by searching EMBASE, MEDLINE, and CINAHL databases. Observational studies were included if they assessed cardiovascular mortality in patients with lymphoma who survived for at least 5 years from time of diagnosis or if they had a median follow-up of 10 years...
August 15, 2018: Cancer Medicine
Arash Abiri, Yichen Ding, Parinaz Abiri, René R Sevag Packard, Vijay Vedula, Alison Marsden, C-C Jay Kuo, Tzung K Hsiai
While virtual reality (VR) has potential in enhancing cardiovascular diagnosis and treatment, prerequisite labor-intensive image segmentation remains an obstacle for seamlessly simulating 4-dimensional (4-D, 3-D + time) imaging data in an immersive, physiological VR environment. We applied deformable image registration (DIR) in conjunction with 3-D reconstruction and VR implementation to recapitulate developmental cardiac contractile function from light-sheet fluorescence microscopy (LSFM). This method addressed inconsistencies that would arise from independent segmentations of time-dependent data, thereby enabling the creation of a VR environment that fluently simulates cardiac morphological changes...
August 15, 2018: Annals of Biomedical Engineering
Barbara N Morrison, James McKinney, Saul Isserow, Daniel Lithwick, Jack Taunton, Hamed Nazzari, Astrid M De Souza, Brett Heilbron, Carlee Cater, Mackenzie MacDonald, Benjamin A Hives, Darren E R Warburton
Background: Underlying coronary artery disease (CAD) is the primary cause of sudden cardiac death in masters athletes (>35 years). Preparticipation screening may detect cardiovascular disease; however, the optimal screening method is undefined in this population. The Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and the American Heart Association (AHA) Preparticipation Screening Questionnaire are often currently used; however, a more comprehensive risk assessment may be required...
2018: BMJ Open Sport & Exercise Medicine
Arunangshu Ghoshal, Shamali Poojary, Anuja Damani, Naveen S Salins, Jayita K Deodhar, Maryann Muckaden
Emergencies in palliative care need to be defined by the potential distress that a clinical issue raises for a person. A 58-year-old male with carcinoma vallecula referred for palliative care presented with recurrent syncopal attacks. On examination, a swelling at the left angle of mandible pressing on the carotid sinus was detected. A clinical diagnosis of carotid sinus syndrome was made, which is an exaggerated response to carotid sinus baroreceptor stimulation and results in dizziness or syncope from transient diminished cerebral perfusion...
July 2018: Indian Journal of Palliative Care
Udaya Ralapanawa, Nuwan Nanayakkara, Kushalee Poornima Jayawickreme, Noorika Wickramasurendra, Sampath Tennakoon
BACKGROUND: Hypertension (HT) is identified as a highly prevalent cardiovascular risk factor and also as a separate disease entity, leading to significant mortality and morbidity. The rate of HT is increasing worldwide with a faster rate identified in developing countries. Thus, it is important to evaluate epidemiological patterns of chronic HT in a developing country like Sri Lanka. METHODOLOGY: This is a cross-sectional descriptive study conducted at the Teaching Hospital Peradeniya, Sri Lanka, to assess symptoms and risk factors among patients with chronic HT...
August 15, 2018: Clinical and Experimental Hypertension: CHE
Le Wang, Fuhong Cheng, Jingbo Hu, Huan Wang, Nana Tan, Shaokang Li, Xiaoling Wang
Essential hypertension (EH) is a major risk factor for cardiovascular disease. Despite considerable efforts to elucidate the pathogenesis of EH, there is an imperious need for novel indicators of EH. This study aimed to develop a method to predict potential biomarkers of EH from the point of view of network. A pathway-based gene-gene interaction (GGI) network model was constructed and analyzed, containing 116 nodes and 1272 connections. The nodes represented EH-related genes, and that connections represented their interactions...
August 12, 2018: Bio Systems
Hassan Allaqaband, David D Gutterman, Andrew O Kadlec
To date, the major focus of diagnostic modalities and interventions to treat coronary artery disease has been the large epicardial vessels. Despite substantial data showing that microcirculatory dysfunction is a strong predictor of future adverse cardiovascular events, very little research has gone into developing techniques for in vivo diagnosis and therapeutic interventions to improve microcirculatory function. In this review, we will discuss the pathophysiology of coronary arteriolar dysfunction, define its prognostic implications, evaluate the diagnostic modalities available, and provide speculation on current and potential therapeutic opportunities...
September 1, 2018: Physiology
Vincent Jachiet, Raphael Lhote, Pierre Rufat, Micheline Pha, Julien Haroche, Sophie Crozier, Corinne Dupel-Potier, Dimitri Psimaras, Zahir Amoura, Fleur Cohen Aubart
OBJECTIVES: Clinical involvement of the nervous system is uncommon during sarcoidosis. Cerebrovascular events are rarely reported during sarcoidosis and may be confused with primary angiitis of the central nervous system. The characteristics and outcomes of cerebrovascular events during sarcoidosis have not been well-evaluated. PATIENTS AND METHODS: We conducted a retrospective case series in our institution with an updated review of the literature from 1962 to 2017 to characterize the clinical presentation, imaging, histology and outcomes of stroke that were thought to be causally related to sarcoidosis...
August 14, 2018: Journal of Neurology
Dahee Chung, Junggu Choi, Jong-Hwan Jang, Tae Young Kim, JungHyun Byun, Hojun Park, Hong-Seok Lim, Rae Woong Park, Dukyong Yoon
Objectives: Electrocardiogram (ECG) data are important for the study of cardiovascular disease and adverse drug reactions. Although the development of analytical techniques such as machine learning has improved our ability to extract useful information from ECGs, there is a lack of easily available ECG data for research purposes. We previously published an article on a database of ECG parameters and related clinical data (ECG-ViEW), which we have now updated with additional 12-lead waveform information...
July 2018: Healthcare Informatics Research
Susan Christian, Martin Somerville, Michael Giuffre, Joseph Atallah
BACKGROUND: Historically, individuals diagnosed with an inherited arrhythmia or cardiomyopathy have been advised to avoid participating in competitive sport. Consequently, these individuals may be more susceptible to weight gain and obesity. METHODS: A retrospective longitudinal chart review was performed for a population of children with a genetic or clinical diagnosis of long-QT syndrome, catecholaminergic polymorphic ventricular tachycardia, hypertrophic cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy...
August 14, 2018: Journal of Cardiovascular Electrophysiology
Andrew F Prouse, Paula Langner, Mary E Plomondon, P Michael Ho, Javier A Valle, Anna E Barón, Ehrin J Armstrong, Stephen W Waldo
Lower extremity arterial thromboembolism is associated with significant morbidity and mortality. We sought to establish temporal trends in the incidence, management and outcomes of lower extremity arterial thromboembolism within the Veterans Affairs Healthcare System (VAHS). We identified patients admitted to VAHS between 2003 and 2014 with a primary diagnosis of lower extremity arterial thromboembolism. Medical and procedural management were ascertained from pharmaceutical and administrative data. Subsequent rates of major adverse limb events (MALE), major adverse cardiovascular events (MACE), and mortality were calculated using Cox proportional hazards models...
August 14, 2018: Vascular Medicine
M C Muñoz Reyes, J M Romero Requena, Y G Piña Alcántara, J Bueno Álvarez-Arenas, A Ortiz Cansado
A middle-aged man with cardiovascular risk factors, who suffered from a slight loss of unilateral vision for 6 months. After obtaining a diagnosis of diffuse choroiditis+papillitis within a probable masquerade syndrome, the patient was referred to outpatient Internal Medicine where this diagnosis was confirmed as an extended neoplastic disease.
August 10, 2018: Archivos de la Sociedad Española de Oftalmología
Jun-Ting Liou, Chen Wei Lin, Chen-Liang Tsai, Yun-Han Wang, Jyun-Heng Lai, Yu-Juei Hsu, Meng-Ting Wang
OBJECTIVE: To examine the risk of cardiovascular disease (CVD) from tiotropium added to inhaled long-acting β2 agonists (LABAs) and inhaled corticosteroids (ICSs) in a nationwide population with chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: This nested case-control study included 65,966 patients with COPD treated with LABAs and ICSs identified from the Taiwan nationwide health care claims database from January 1, 2007, through June 30, 2011...
August 10, 2018: Mayo Clinic Proceedings
Dejan Jakimovski, Sirin Gandhi, Ivo Paunkoski, Niels Bergsland, Jesper Hagemeier, Deepa P Ramasamy, David Hojnacki, Channa Kolb, Ralph Hb Benedict, Bianca Weinstock-Guttman, Robert Zivadinov
BACKGROUND: Cardiovascular diseases (CVDs) are more frequent in multiple sclerosis (MS) patients when compared to controls. In particular, CVDs are linked with higher accumulation of lesions and advanced brain atrophy. OBJECTIVE: To investigate whether CVDs contribute to accelerated lesion accumulation and brain atrophy over 5-years in patients with MS. METHODS: 194 MS patients and 43 controls without neurologic disease were followed for 5-years...
August 13, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Hiroyuki Ueda, Yoichi Miyazaki, Nobuo Tsuboi, Keita Hirano, Shinya Yokote, Emi Kobayashi, Makoto Ogura, Tetsuya Kawamura, Munekazu Ryuzaki, Takashi Yokoo
Objective This case series aimed to identify the clinical and pathological characteristics of elderly patients (≥60 years) with biopsy-proven IgA vasculitis with nephritis (IgAVN). Methods The clinical and pathological presentation and treatment outcomes were compared between two groups. Patients Patients with IgAVN who were ≥19 years old at the time of their renal biopsy were divided into elderly (≥60 years) and adult (19-59 years) groups. Results Of the 23 patients in our study, 13 were elderly. In the elderly group, the median age at the diagnosis was 68 years (range, 60-85 years), with a median follow-up period of 15 months (range, 3-80 months)...
August 10, 2018: Internal Medicine
Francois Brial, Aurélie Le Lay, Marc-Emmanuel Dumas, Dominique Gauguier
Evidence from the literature keeps highlighting the impact of mutualistic bacterial communities of the gut microbiota on human health. The gut microbita is a complex ecosystem of symbiotic bacteria which contributes to mammalian host biology by processing, otherwise, indigestible nutrients, supplying essential metabolites, and contributing to modulate its immune system. Advances in sequencing technologies have enabled structural analysis of the human gut microbiota and allowed detection of changes in gut bacterial composition in several common diseases, including cardiometabolic disorders...
August 12, 2018: Cellular and Molecular Life Sciences: CMLS
Daniel Nierenberg, Annette R Khaled, Orielyz Flores
The development and testing of nanomaterials is an area of interest due to promising diagnostic and therapeutic applications in the treatment of diseases like cancer or cardiovascular disease. While extensive studies of the physicochemical properties of nanoparticles (NPs) are available, the investigation of the protein corona (PC) that is formed on NPs in biofluids is a relatively new area of research. The fact that few NPs are in clinical use indicates that the biological identity of NPs, which is in large part due to the PC formed in blood or other bodily fluids, may be altered in ways yet to be fully understood...
July 2018: Reports of Practical Oncology and Radiotherapy
Carmen M Lara-Rojas, Luis M Pérez-Belmonte, María D López-Carmona, Ricardo Guijarro-Merino, María R Bernal-López, Ricardo Gómez-Huelgas
AIMS: To analyze national trends in the rates of hospitalizations (all-cause and by principal discharge diagnosis) in total diabetic population of Spain. METHODS: We carried out a nation-wide population-based study of all diabetic patients hospitalized between 1997 and 2010. All-cause hospitalizations, hospitalizations by principal discharge diagnosis, mean age, Charlson Comorbidity Index, readmission rates and length of hospital stay were examined. Annual rates adjusted for age and sex were analyzed and trends were calculated...
August 9, 2018: European Journal of Internal Medicine
Renate K Meier
Polycystic ovary syndrome (PCOS) is a commonly occurring endocrine disorder characterized by hirsutism, anovulation, and polycystic ovaries. Often comorbid with insulin resistance, dyslipidemia, and obesity, it also carries significant risk for the development of cardiovascular and metabolic sequelae, including diabetes and metabolic syndrome. Traditionally, the treatment of patients with PCOS has focused on relief of symptoms. Here, the criteria for the diagnosis of PCOS are reviewed with an emphasis on the stratification of subtypes by metabolic features...
September 2018: Nursing Clinics of North America
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