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endocrine responses

Andrew W Manigault, Wilson S Figueroa, Cari R Hollenbeck, Anna E Mendlein, Alex Woody, Katrina R Hamilton, Matt C Scanlin, Ryan C Johnson, Peggy M Zoccola
OBJECTIVE: Revealing one's sexual identity to others is a complex process marked by a shift in the types of stressors faced by sexual minority young adults. Such stressors influence the secretion of health-relevant hormones, including cortisol, yet how dimensions of disclosure (i.e., the degree and context) influence neuroendocrine functioning remains poorly understood. The current study examined the association between disclosure context (disclosure to family members, friends/co-workers/acquaintances, and members of religious groups) and diurnal cortisol while allowing disclosure to vary in degree (i...
August 9, 2018: Psychosomatic Medicine
Alexandra E Butler, David Kirakossian, Tatyana Gurlo, Fuying Gao, Giovanni Coppola, Peter C Butler
The pancreatic duct gland (PDG) compartment has been proposed as a potential stem cell niche based on its coiled tubular structure embedded in mesenchyme, its proliferation and expansion in response to pancreatic injury, and the fact that it contains endocrine and exocrine epithelial cells. Little is known of the molecular signature of the PDG compartment in either a quiescent state or the potentially activated state during beta cell stress characteristic of diabetes. To address this, we performed RNA sequencing on RNA obtained from PDGs of wild type versus pre-diabetic HIP rats, a model of type 2 diabetes...
August 10, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
Tandi E Matsha, Andre P Kengne, Stanton Hector, Desiree L Mbu, Yandiswa Y Yako, Rajiv T Erasmus
Early identification of individuals with elevated risk of developing diabetes mellitus, followed by the implementation of effective prevention interventions can delay the onset of the disease and related complications. In this regard, recent studies have shown that miRNAs are useful as early markers of certain disease types, including diabetes. We used high throughput sequencing to assess miRNA expression profiles from whole blood of 12 individuals with screen-detected diabetes, 12 with prediabetes and 12 with normal glucose tolerance, matched for age, blood pressure, smoking and body mass index...
July 17, 2018: Oncotarget
Boris V Krivoshiev, Gerrit T S Beemster, Katrien Sprangers, Bart Cuypers, Kris Laukens, Ronny Blust, Steven J Husson
The flame retardant, 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide (DOPO), has been receiving great interest given its superior fire protection properties, and its predicted low level of persistence, bioaccumulation, and toxicity. However, empirical toxicological data that are essential for a complete hazard assessment are severely lacking. In this study, we attempted to identify the potential toxicological modes of action by transcriptome (RNA-seq) profiling of the human liver hepatocellular carcinoma cell line, HepG2...
May 8, 2018: Toxicology Research
Thomas Morville, Ronni E Sahl, Samuel Aj Trammell, Jens S Svenningsen, Matthew P Gillum, Jørn W Helge, Christoffer Clemmensen
BACKGROUND: Exercise has profound pleiotropic health benefits, yet the underlying mechanisms remain incompletely understood. Endocrine FGF21, bile acids (BAs), and BA-induced FGF19 have emerged as metabolic signaling molecules. Here, we investigated if dissimilar modes of exercise, resistance exercise (RE) and endurance exercise (EE), regulate plasma BAs, FGF19, and FGF21 in humans. METHODS: Ten healthy, moderately trained males were enrolled in a randomized crossover study of 1 hour of bicycling at 70% of VO2peak (EE) and 1 hour of high-volume RE...
August 9, 2018: JCI Insight
Jonathan T Lei, Jieya Shao, Jin Zhang, Michael Iglesia, Doug W Chan, Jin Cao, Meenakshi Anurag, Purba Singh, Xiaping He, Yoshimasa Kosaka, Ryoichi Matsunuma, Robert Crowder, Jeremy Hoog, Chanpheng Phommaly, Rodrigo Goncalves, Susana Ramalho, Raquel Mary Rodrigues Peres, Nindo Punturi, Cheryl Schmidt, Alex Bartram, Eric Jou, Vaishnavi Devarakonda, Kimberly R Holloway, W Victoria Lai, Oliver Hampton, Anna Rogers, Ethan Tobias, Poojan A Parikh, Sherri R Davies, Shunqiang Li, Cynthia X Ma, Vera J Suman, Kelly K Hunt, Mark A Watson, Katherine A Hoadley, E Aubrey Thompson, Xi Chen, Shyam M Kavuri, Chad J Creighton, Christopher A Maher, Charles M Perou, Svasti Haricharan, Matthew J Ellis
RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor-positive (ER+ ) breast cancer, but their role in disease pathogenesis remains unclear. We examined multiple ESR1 fusions and found that two, both identified in advanced endocrine treatment-resistant disease, encoded stable and functional fusion proteins. In both examples, ESR1-e6>YAP1 and ESR1-e6>PCDH11X, ESR1 exons 1-6 were fused in frame to C-terminal sequences from the partner gene. Functional properties include estrogen-independent growth, constitutive expression of ER target genes, and anti-estrogen resistance...
August 7, 2018: Cell Reports
Eduardo Roggero, Adriana Del Rey, Johannes Wildmann, Hugo Besedovsky
Evidence suggests that natural and adaptive immune responses can trigger neuroendocrine responses. Here, we discuss changes in the activity of the hypothalamus-pituitary-adrenal axis and in autonomic nerves, predominantly of the sympathetic nervous system, in a mouse model of acute infection with Trypanosoma cruzi. The endocrine response includes a marked increased release of glucocorticoid and a decrease of immune-stimulatory hormones, such as dehydroepiandrosterone sulfate, prolactin, and growth hormone during infection...
August 8, 2018: Annals of the New York Academy of Sciences
Sameera Abuaish, Richard L Spinieli, Patrick O McGowan
The maternal environment has a profound effect on the development of offspring, including responses to stress mediated by the hypothalamic-pituitary-adrenal (HPA) axis. In rodents, perinatal high fat diet (HFD) has been shown to program the HPA axis in a manner that persists throughout adulthood, however the effects of perinatal HFD on stress-related behaviors and physiology in neonates are limited. The first two weeks of life in rodents are known as the stress hyporesponsive period, during which animals do not respond to stressors that are otherwise known to elicit behavioral and physiological responses in mature animals...
August 2, 2018: Psychoneuroendocrinology
Sabrina Chiloiro, Tommaso Tartaglione, Ettore Domenico Capoluongo, Flavia Angelini, Vincenzo Arena, Antonella Giampietro, Antonio Bianchi, Angelo Zoli, Alfredo Pontecorvi, Cesare Colosimo, Laura De Marinis
Context: Primary autoimmune hypophysitis (PAH) evolves in most of untreated cases in irreversible hypopituitarism. PAH outcome, instead, after immunosuppressive treatment hasn't been completely clarified. Objective: To evaluate hypophysitis and pituitary function outcomes. Design: A prospective, double-arm study with a 2-year follow-up. Setting: Referral center for pituitary disease. Patients: 20 PAH cases...
August 1, 2018: Journal of Clinical Endocrinology and Metabolism
Maria Elvira Brocca, Luis Miguel Garcia-Segura
The modulation of brain function and behavior by steroid hormones was classically associated with their secretion by peripheral endocrine glands. The discovery that the brain expresses the enzyme aromatase, which produces estradiol from testosterone, expanded this traditional concept. One of the best-studied roles of brain estradiol synthesis is the control of reproductive behavior. In addition, there is increasing evidence that estradiol from neural origin is also involved in a variety of non-reproductive functions...
August 6, 2018: Cellular and Molecular Neurobiology
Pietro Amodeo, Enrico D'Aniello, Fanny Defranoux, Angela Marino, Livia D'Angelo, Michael T Ghiselin, Ernesto Mollo
Fish have proven to be valuable models in the study of the endocrine control of appetite in response to peripheral signals of energetic and nutritional status. In parallel, a growing body of literature points to the importance of sensory experiences as factors affecting food choice in fish, with a special focus on visual and chemical signals allowing discrimination of potential foods within a 3D environment. Accordingly, waterborne compounds, such as monosaccharides or amino acids, are regarded as the main "olfactory" cues driving fish alimentary behavior...
2018: Results and Problems in Cell Differentiation
Mohamed Ahmed, Edmund Miller
Macrophage migration inhibitory factor (MIF) has been described as a pro-inflammatory cytokine and regulator of neuro-endocrine function. It plays an important upstream role in the inflammatory cascade by promoting the release of other inflammatory cytokines such as TNF-alpha and IL-6, ultimately triggering a chronic inflammatory immune response. As lungs can synthesize and release MIF, many studies have investigated the potential role of MIF as a biomarker in assessment of patients with pulmonary arterial hypertension (PAH) and using anti-MIFs as a new therapeutic modality for PAH...
June 30, 2018: Global Cardiology Science & Practice
Santosha Vardhana, Kara Cicero, Moises J Velez, Craig H Moskowitz
The programmed death-1 (PD-1) receptor checkpoint inhibitors nivolumab and pembrolizumab represent an important therapeutic advance in the treatment of relapsed or refractory classical Hodgkin lymphoma (cHL). Clinical trials have shown substantial therapeutic activity and an acceptable safety profile in heavily pretreated patients, resulting in U.S. Food and Drug Administration approval of nivolumab for the treatment of cHL that has relapsed or progressed after either autologous hematopoietic cell transplantation (auto-HCT) and brentuximab vedotin treatment or three or more lines of systemic therapy (including auto-HCT), and of pembrolizumab for adult or pediatric patients with refractory cHL or cHL that has relapsed after three or more prior therapies...
August 6, 2018: Oncologist
Yunbing Ma, Qian Wang, Debria Joe, Manqi Wang, Matthew D Whim
Hypoglycemia activates the counterregulatory response (CRR), a neural-endocrine reflex that restores euglycemia. Although effective if occasionally activated, repeated induction of the CRR leads to a decline in responsiveness and prolonged exposure to hypoglycemia. The mechanism underlying this impairment is not known. We found that the reduction in epinephrine release that characterizes a suppressed CRR involves a long-lasting form of sympatho-adrenal synaptic plasticity. Using optogenetically evoked catecholamine release, we show that recurrent hypoglycemia reduced the secretory capacity of mouse adrenal chromaffin cells...
August 6, 2018: Journal of Clinical Investigation
F Allerton, F Swinbourne, L Barker, V Black, A Kathrani, M Tivers, T Henriques, C Kisielewicz, M Dunning, A Kent
BACKGROUND: Gall bladder mucoceles (GBM) are a leading cause of biliary disease in dogs with several breeds, including the Shetland Sheepdog, American Cocker Spaniel, Chihuahua, Pomeranian, and Miniature Schnauzer apparently predisposed. OBJECTIVE: To determine risk factors, clinical features, and response to treatment of GBM in Border terriers (BT). ANIMALS: Medical records of 99 dogs (including 51 BT) with an ultrasonographic (±histopathologic) diagnosis of GBM from three referral centers in the United Kingdom were collected...
August 5, 2018: Journal of Veterinary Internal Medicine
Robert A Huggins, Andrea R Fortunati, Ryan M Curtis, David P Looney, Chris A West, Elaine C Lee, Maren S Fragala, Mathew L Hall, Douglas J Casa
Huggins, RA, Fortunati, AR, Curtis, RM, Looney, DP, West, CA, Lee, EC, Fragala, MS, Hall, ML, and Casa, DJ. Monitoring blood biomarkers and training load throughout a collegiate soccer season. J Strength Cond Res XX(X): 000-000, 2018-This observational study aimed to characterize the responses of a comprehensive panel of biomarkers, observed ranges, training load (TL) metrics, and performance throughout the collegiate soccer season (August-November). Biomarkers (n = 92) were collected before the start of pre-season (PS), in-season weeks (W)1, W4, W8, and W12 in NCAA Division I male soccer players (n = 20, mean ± SD; age = 21 ± 1 years, height = 180 ± 6 cm, body mass = 78...
August 2, 2018: Journal of Strength and Conditioning Research
Shaopu Wang, Susanne Meese, Susanne E Ulbrich, Heinrich Bollwein, Monika Röntgen, Ulrike Gimsa, Angela Schwarm
This in vitro study examined the ability of important immune modulators [β-hydroxybutyrate (BHB), cortisol, prolactin, isoproterenol and insulin] to influence the responsiveness of peripheral blood mononuclear cells (PBMC) from multiparous dairy cows 29 ± 2 days before and 14 ± 3 days after calving. The activation and proliferation of PBMC in response to the mitogen phytohemagglutinin was estimated by the oxygen consumption rate after 24 hr and the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5diphenyl tetrazolium bromide) method after 72 hr respectively...
August 3, 2018: Journal of Animal Physiology and Animal Nutrition
Alexander Rebl, Marieke Verleih, Mareen Nipkow, Simone Altmann, Ralf Bochert, Tom Goldammer
The complex and still poorly understood nature of thermoregulation in various fish species complicates the determination of the physiological status on the basis of diagnostic marker genes and indicative molecular pathways. The present study aimed to compare the physiological impacts of both gradual and acute temperature rise from 18 to 24°C on maraena whitefish in aquaculture. Microarray-based transcriptome profiles in the liver, spleen and kidney of heat-stressed maraena whitefish revealed the modulation of a significantly higher number of genes in those groups exposed to gradually rising temperatures compared with the acutely stressed groups, which might reflect early adaptation mechanisms...
2018: Frontiers in Genetics
Talal Hilal, Matthew Covington, Heidi E Kosiorek, Christine Zwart, Idris T Ocal, Barbara A Pockaj, Donald W Northfelt, Bhavika K Patel
Neoadjuvant endocrine therapy (NET) is increasingly used for the treatment of estrogen receptor positive, HER2 negative breast cancer. We evaluated whether MRI phenotype and background parenchymal enhancement (BPE) can predict response to NET. Patients with localized breast cancer treated with NET and had a pre-treatment breast MRI were identified. Baseline MRI phenotype and BPE was interpreted by a single radiologist blinded to the results of systemic therapy. Response was defined as stable disease or reduction in tumor size on clinical and/or ultrasound examination...
July 31, 2018: Breast Journal
Robyn Jane McQuaid, Roderick Dunn, Shlomit Jacobson-Pick, Hymie Anisman, Marie-Claude Audet
Environmental enrichment is typically associated with enhanced well-being, improved cognitive function and stress resilience. However, in some instances grouping adult male mice in enriched conditions promoted a stressful environment, which resulted in elevated endocrine, monoamine and inflammatory outcomes in response to subsequent stressor exposure. The current investigation examined whether raising male mice in an enriched environment (EE) would modulate social and anxiety-like behaviors in early adulthood and influence brain expression of pro-inflammatory cytokines and brain-derived neurotrophic factor (BDNF)...
2018: Frontiers in Behavioral Neuroscience
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