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https://www.readbyqxmd.com/read/30517676/adipose-tissue-exosomal-proteomic-profile-reveals-a-role-on-placenta-glucose-metabolism-in-gestational-diabetes-mellitus
#1
Nanthini Jayabalan, Andrew Lai, Valeska Ormazabal, Stefanie Adam, Dominic Guanzon, Carlos Palma, Katherin Scholz-Romero, Ratana Lim, Thomas Jansson, Harold David McIntyre, Martha Lappas, Carlos Salomon
Context: Molecules produced by adipose tissue (AT) function as an endocrine link between maternal AT and fetal growth by regulating placental function in normal and gestational diabetes mellitus (GDM). Objective: We hypothesised that AT-derived exosomes from women with GDM carry a specific set of proteins that influences glucose metabolism in placenta. Design: Exosomes were isolated from omental AT-conditioned media from pregnant women with normal glucose tolerance (exo-NGT, n=65) and women with GDM (exo-GDM, n=82)...
December 3, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30517244/mourning-and-takotsubo-cardiomyopathy-neuroendocrine-implications-and-nutritional-management
#2
Maria Teresa Fialho de Sousa Campos, Francisco Miguel Quintão Valente, Raquel Maria Amaral Araújo, Josefina Bressan
This article aims to make reference to some recent mourning aspects considered risk factors for cardiovascular disease, specifically the Takotsubo cardiomyopathy. The objective was to describe the stress from the death of a loved one combining it to the possibility of occurrence of Takotsubo cardiomyopathy through the perception of a traumatic event by the cortex, which triggers the subcortical brain circuit affecting the endocrine response. Given the growing acknowledgement of this cardiomyopathy, it is possible to contextualize the nutritional behaviours and decisions surrounding it, whose benefits must exceed the condition of temporary cardiac dysfunction and extend to food choices that have some influence in the limbic system...
October 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/30517079/a-turkish-girl-with-h-syndrome-stunted-growth-and-development-of-autoimmune-insulin-dependent-diabetes-mellitus-in-the-6th-year-of-diagnosis
#3
Can Ozlu, Gul Yesiltepe Mutlu, Sukru Hatun
Background H syndrome ([OMIM] 602782) is an autosomal recessive disorder with systemic manifestations and characteristic skin lesions, caused by mutations of the SLC29A3 gene. Short stature and diabetes mellitus are the major endocrine problems related to H syndrome, however, clear data from clinical follow-up of H syndrome patients is lacking in the literature. Case presentation Here, we present follow-up of a Turkish girl diagnosed with H syndrome at the age of 10 with a homozygous 310(c.933T>A, p.C310X) early stop codon mutation on exon 6 of the SLC29A3 gene...
December 5, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30515568/ptpn2-deficiency-along-with-activation-of-nuclear-akt-predict-endocrine-resistance-in-breast-cancer
#4
Elin Karlsson, Cynthia Veenstra, Jon Gårsjö, Bo Nordenskjöld, Tommy Fornander, Olle Stål
PURPOSE: The protein tyrosine phosphatase, non-receptor type 2 (PTNP2) regulates receptor tyrosine kinase signalling, preventing downstream activation of intracellular pathways like the PI3K/Akt pathway. The gene encoding the protein is located on chromosome 18p11; the 18p region is commonly deleted in breast cancer. In this study, we aimed to evaluate PTPN2 protein expression in a large breast cancer cohort, its possible associations to PTPN2 gene copy loss, Akt activation, and the potential use as a clinical marker in breast cancer...
December 4, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30515264/targeting-the-invincible-barrier-for-drug-delivery-in-solid-cancers-interstitial-fluid-pressure
#5
Steven K Libutti, Lawrence Tamarkin, Naris Nilubol
Although a number of new systemic therapeutic options in patients with advanced solid cancers have emerged due to the improved knowledge of molecular dysregulation in cancers, the durable, long-term, objective responses infrequently occur. This editorial article highlights the major limitation of current systemic therapy due to an inefficient drug delivery. While several mechanisms contributing to cancer drug resistance have been described, the common key barrier among solid cancers is the unique tumor microenvironment that causes the high interstitial fluid pressure (IFP)...
November 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/30513833/gpcr-modulation-in-breast-cancer
#6
REVIEW
Rosamaria Lappano, Yves Jacquot, Marcello Maggiolini
Breast cancer is the most prevalent cancer found in women living in developed countries. Endocrine therapy is the mainstay of treatment for hormone-responsive breast tumors (about 70% of all breast cancers) and implies the use of selective estrogen receptor modulators and aromatase inhibitors. In contrast, triple-negative breast cancer (TNBC), a highly heterogeneous disease that may account for up to 24% of all newly diagnosed cases, is hormone-independent and characterized by a poor prognosis. As drug resistance is common in all breast cancer subtypes despite the different treatment modalities, novel therapies targeting signaling transduction pathways involved in the processes of breast carcinogenesis, tumor promotion and metastasis have been subject to accurate consideration...
December 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30513575/the-emerging-role-of-insulin-receptor-isoforms-in-thyroid-cancer-clinical-implications-and-new-perspectives
#7
REVIEW
Veronica Vella, Roberta Malaguarnera
Thyroid cancer (TC) is the most common endocrine tumor. Although the majority of TCs show good prognoses, a minor proportion are aggressive and refractory to conventional therapies. So far, the molecular mechanisms underlying TC pathogenesis are incompletely understood. Evidence suggests that TC cells and their precursors are responsive to insulin and insulin-like growth factors (IGFs), and often overexpress receptors for insulin (IR) and IGF-1 (IGF-1R). IR exists in two isoforms, namely IR-A and IR-B. The first binds insulin and IGF-2, unlike IR-B, which only binds insulin...
November 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30513476/why-upfront-use-of-cdk-inhibitors-for-the-treatment-of-advanced-breast-cancer-may-be-wasteful-and-how-we-can-increase-their-value
#8
Saroj Niraula
Three Cyclin Dependent Kinase 4/6 (CDK) inhibitors have been approved by the United Stated Food and Drug Administration for front line treatment of advanced hormone receptor positive breast cancer based on improvements in progression free survival against endocrine monotherapy. Two clinical trials have so far reported results on overall survival but both are negative. CDK inhibitors are usually tolerated well but they do add to inconvenience and cost - for example, grade III-IV neutropenia occur at a frequency of over 60% requiring frequent blood work at least during the initial months of treatment...
November 26, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30513371/identification-of-septin12-as-a-novel-target-of-the-androgen-and-estrogen-receptors-in-human-testicular-cells
#9
Pao-Lin Kuo, Jie-Yun Tseng, Hau-Ing Chen, Chia-Yun Wu, Hany A Omar, Chia-Yih Wang, Han-Yi Cheng, Chao-Chin Hsu, Tzu-Fun Fu, Yen-Ni Teng
SEPTIN12 (SEPT12) is a testis-enriched gene that is downregulated in the testis of infertile men with severe spermatogenic defects. While SEPT12 is involved in spermatogenic failure and sperm motility disorder, SEPT12 transcriptional regulation is still unknown. Here we report the promoter region of SEPT12 as a 245 bp segment upstream from the transcription start site. One androgen receptor (AR) and two of estrogen receptor α (ERα) binding sites were on this region were identified initially by Bioinformatics prediction and confirmed by chromatin immunoprecipitation assay...
December 1, 2018: Biochimie
https://www.readbyqxmd.com/read/30511942/comparison-of-endocrinological-and-cytokine-response-to-trauma-in-laparoscopic-and-conventional-appendectomy-in-patients-with-acute-appendicitis
#10
Erol Piskin, Mesut Ozdedeoglu, Bahtiyar Muhammedoglu, Yigit Mehmet Ozgun, Anhmet Kusdemir
PURPOSE: In this study, we compared the endocrine and cytokine reaction of the patients which laparoscopic and conventional appendectomy was done for acute appendicitis. MATERIALS AND METHOD: 50 patients who were operated for acute appendicitis in Ankara Atatürk Research and Training Hospital between the dates December 2013 and February 2014 were enrolled and grouped as either laparoscopic or conventional. Serum ACTH, IL-6 and CRP levels were obtained at induction of anesthesia and postoperative 6th hour...
November 29, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/30511337/sex-and-gender-differences-in-ischemic-heart-disease-endocrine-vascular-disease-approach-eva-study-design
#11
Valeria Raparelli, Marco Proietti, Andrea Lenzi, Stefania Basili
Improvements in ischemic heart disease (IHD) management have been unbalanced between sexes, with coronary microvascular dysfunction considered the likely underlying reason. The Endocrine Vascular disease Approach (EVA) is an observational study ( Clinicaltrial.gov NCT02737982) aiming to assess sex and gender interactions between coronary circulation, sexual hormones, and platelet function. Consecutive patients with IHD undergoing coronary angiography will be recruited: (1) to assess sex and gender differences in angiographic reperfusion indexes; (2) to evaluate the effects of estrogen/androgen on sex-related differences in myocardial ischemia; (3) to investigate the platelet biology differences between men and women with IHD; (4) to verify sex- and gender-driven interplay between response to percutaneous coronary intervention, platelets, sex hormones, and myocardial damage at baseline and its impact on 12-month outcomes...
December 3, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30510455/comparative-efficacy-of-different-targeted-therapies-plus-fulvestrant-for-advanced-breast-cancer-following-progression-on-prior-endocrine-therapy-a-network-meta-analysis
#12
Tingting Zhang, Fubin Feng, Wenge Zhao, Yan Yao, Jinhui Tian, Chao Zhou, Chuanxin Zang, Cun Liu, Xue Wang, Changgang Sun
Background: We performed a network meta-analysis of randomized controlled trials (RCTs) to indirectly compare the efficacy of different targeted agents with fulvestrant for patients with hormone-receptor-positive (HR+) and human epidermal growth factor receptor type 2-negative (HER2-) advanced breast cancer (ABC) following progression on prior endocrine therapy. Methods: The titles/abstracts were searched from the PubMed, EMBASE, and the Cochrane Library databases for RCTs to evaluate the efficacy of palbociclib plus fulvestrant vs alternative targeted therapies plus fulvestrant for postmenopausal HR+/HER2- ABC following progression on prior endocrine therapy...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30509093/prognostic-value-of-functional-tumor-burden-on-68ga-dotatoc-pet-ct-in-patients-with-pancreatic-neuro-endocrine-tumors
#13
J Ohnona, V Nataf, M Gauthe, S Balogova, O Belissant Benesty, J Zhang-Yin, J N Talbot, F Montravers
Despite their relative quiescence, pancreatic neuro-endocrine tumors (pNET) can correspond to various presentations and outcomes. Several prognostic factors have been identified, including maximal standardized uptake value of the most intense focus (maxSUVmax) on Positron Emission Tomography (PET) with a somatostatin analogue. Herein, we investigate the prognostic value on progression free-survival of the total functional tumor volume (TFTV) measured by 68Ga-DOTATOC PET. From patients who underwent 68Ga-DOTATOC PET from 2008 to 2014, we selected consecutive patients with G1 or G2 pNET (2010 World Health Organization classification), at least one abnormal focus on PET and available follow-up data...
August 9, 2018: Neoplasma
https://www.readbyqxmd.com/read/30508887/treatment-of-severe-rash-caused-by-crizotinib-with-both-traditional-chinese-medicine-and-western-medicine-two-case-reports-and-literature-review
#14
Shu-Yue Zheng, Wen Shen, Yan-Mei Peng, Hui-Juan Cui, Hua Duan, Yu-Qin Qiu, Qiang Li, Jing-Yi Zhang, Chen-Yao Sun, Xu Zhang
RATIONALE: Lung adenocarcinoma is the most common pathologic pattern of lung cancer. During the past decades, a number of targeted agents have been explored to treat advanced lung adenocarcinoma. Recently, Crizotinib, the antagonist of anaplastic lymphoma kinase (ALK), has been widely used in ALK-rearranged lung cancer treatment. Crizotinib is generally well tolerated while its most frequent adverse events include visual disorders, gastrointestinal disturbances, cardiac and endocrine abnormalities...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30508572/biphasic-effects-of-perfluorooctanoic-acid-on-steroidogenesis-in-mouse-leydig-tumour-cells
#15
Meiping Tian, Qingyu Huang, Heng Wang, Francis L Martin, Liangpo Liu, Jie Zhang, Heqing Shen
Perfluorooctanoic acid (PFOA) is a persistent organic pollutant, which may possess endocrine disrupting properties. Herein, we investigated the possible mechanism(s) of toxicity and steroidogenesis in mouse Leydig cells. MLTC-1 (mouse Leydig tumour cells) cells were exposed to 0, 50, 100 or 200 μM PFOA for 48 h to ascertain their effects on the nuclear (membrane) receptor responses, steroidogenesis pathway and related regulated gene expression and steroid hormone secretion profiles. Our results reveal that nuclear receptors PXR, SR-B1 and LHR are sensitive to PFOA exposure...
November 30, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/30506455/prediction-of-therapy-response-in-bone-predominant-metastatic-breast-cancer-comparison-of-18-f-fluorodeoxyglucose-and-18-f-fluoride-pet-ct-with-whole-body-mri-with-diffusion-weighted-imaging
#16
Gurdip K Azad, Benjamin P Taylor, Adrian Green, Ines Sandri, Angela Swampillai, Mark Harries, Hartmut Kristeleit, Janine Mansi, Vicky Goh, Gary J R Cook
PURPOSE: To compare [18 F]-fluorodeoxyglucose (FDG) and [18 F]-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) with whole-body magnetic resonance with diffusion-weighted imaging (WB-MRI), for endocrine therapy response prediction at 8 weeks in bone-predominant metastatic breast cancer. PATIENTS AND METHODS: Thirty-one patients scheduled for endocrine therapy had up to five bone metastases measured [FDG, NaF PET/CT: maximum standardized uptake value (SUVmax ); WB-MRI: median apparent diffusion coefficient (ADCmed )] at baseline and 8 weeks...
December 1, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30501904/endocrine-treatment-of-high-grade-serous-ovarian-carcinoma-quantification-of-efficacy-and-identification-of-response-predictors
#17
Barbara Stanley, Robert L Hollis, Hugo Nunes, Jonathan D Towler, Xiangfei Yan, Tzyvia Rye, Carol Dawson, Melanie J Mackean, Fiona Nussey, Michael Churchman, C Simon Herrington, Charlie Gourley
OBJECTIVES: The role of endocrine therapy (ET) in high grade serous ovarian carcinoma (HGSOC) is poorly defined due to the lack of phase III data and significant heterogeneity of clinical trials performed. In this study, we sought to identify predictive factors of endocrine sensitivity in HGSOC. METHODS: HGSOC patients who received at least four weeks of ET for relapsed disease following one line of chemotherapy at the Edinburgh Cancer Centre were identified. Exclusion criteria were use of endocrine therapy as maintenance therapy or of unknown duration...
November 27, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30501540/the-evolving-role-of-receptors-as-predictive-biomarkers-for-metastatic-breast-cancer
#18
Carlos Martínez-Pérez, Arran K Turnbull, J Michael Dixon
In breast cancer, estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) are essential biomarkers to predict response to endocrine and anti-HER2 therapies, respectively. In metastatic breast cancer, the use of these receptors and targeted therapies present additional challenges: temporal heterogeneity, together with limited sampling methodologies, hinders receptor status assessment, and the constant evolution of the disease invariably leads to resistance to treatment. Areas covered: This review summarizes the genomic abnormalities in ER and HER2, such as mutations, amplifications, translocations, and alternative splicing, emerging as novel biomarkers that provide an insight into underlying mechanisms of resistance and hold potential predictive value to inform treatment selection...
December 3, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/30500912/bisphenol-a-alters-bmal1-per2-and-rev-erba-mrna-and-requires-bmal1-to-increase-neuropeptide-y-expression-in-hypothalamic-neurons
#19
Neruja Loganathan, Ashkan Salehi, Jennifer A Chalmers, Denise D Belsham
Bisphenol A (BPA), a ubiquitous, environmental endocrine disruptor, is considered an obesogen. Its role in the hypothalamic control of energy balance, however, remains largely unexplored. As disruption of the circadian clock is tightly associated with metabolic consequences, we explored how BPA affects the components of the molecular circadian clock in the feeding-related neurons of the hypothalamus. In immortalized POMC and NPY/AgRP-expressing hypothalamic cell lines and primary culture, we describe that BPA significantly alters mRNA expression of circadian clock genes Bmal1, Per2 and Rev-Erbα...
November 30, 2018: Endocrinology
https://www.readbyqxmd.com/read/30498946/diversity-of-central-oxytocinergic-projections
#20
REVIEW
Gustav F Jirikowski
Localization and distribution of hypothalamic neurons expressing the nonapeptide oxytocin has been extensively studied. Their projections to the neurohypophyseal system release oxytocin into the systemic circulation thus controlling endocrine events associated with reproduction in males and females. Oxytocinergic neurons seem to be confined to the ventral hypothalamus in all mammals. Groups of such cells located outside the supraoptic and the paraventricular nuclei are summarized as "accessory neurons...
November 29, 2018: Cell and Tissue Research
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