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Vitamin D Gut

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https://www.readbyqxmd.com/read/30328681/effects-of-quercetin-intervention-on-cognition-function-in-app-ps1-mice-was-affected-by-vitamin-d-status
#1
Menglian Lv, Shengyi Yang, Lingkai Cai, Li-Qiang Qin, Bing-Yan Li, Zhongxiao Wan
SCOPE: To explore how quercetin would affect memory impairments in APP/PS1 mice under different vitamin D status. METHODS AND RESULTS: APP/PS1 mice were divided into 4 groups, i.e. control (CON), and Low, Medium and High VD (LVD, MVD and HVD) supplemented with quercetin. During Morris Water Maze test, mice of LVD group functioned best for improving cognitive function demonstrated by reduced latency to platform, and increased number of crossing and swimming distance in the target quadrant...
October 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/30324342/vitamin-d-and-the-gut-microbiome-a-systematic-review-of-in-vivo-studies
#2
Mary Waterhouse, Bronwyn Hope, Lutz Krause, Mark Morrison, Melinda M Protani, Martha Zakrzewski, Rachel E Neale
PURPOSE: Variation in the human microbiome has been linked with a variety of physiological functions, including immune regulation and metabolism and biosynthesis of vitamins, hormones, and neurotransmitters. Evidence for extraskeletal effects of vitamin D has been accruing and it has been suggested that the effect of vitamin D on health is partially mediated through the microbiome. We aimed to critically evaluate the evidence linking vitamin D and the gastrointestinal microbiome. METHODS: We systematically searched the Embase, Web of Science, PubMed and CINAHL databases, including peer-reviewed publications that reported an association between a measure of vitamin D and the gastrointestinal microbiome in humans or experimental animals...
October 15, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/30252633/association-of-serum-vitamin-d-concentration-with-clinical-symptoms-and-quality-of-life-in-patients-with-irritable-bowel-syndrome
#3
Amir Abbasnezhad, Reza Amani, Amin Hasanvand, Esmaeil Yousefi Rad, Meysam Alipour, Somayeh Saboori, Razieh Choghakhori
OBJECTIVE: A high prevalence of vitamin D deficiency (VDD) in gastrointestinal (GI) disorders and the role of vitamin D in the function of the gut have been shown previously. Therefore, we aimed to evaluated the VDD and the possible association of the GI symptoms severity and quality of life (QoL) score with the serum levels of vitamin D in irritable bowel syndrome (IBS). METHODS: A total of 90 patients with IBS based on Rome III criteria enrolled in the study from the tertiary referral university hospital...
September 25, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/30181757/vitamin-d-the-gut-microbiome-and-inflammatory-bowel-disease
#4
REVIEW
Seyed-Amir Tabatabaeizadeh, Niayesh Tafazoli, Gordon A Ferns, Amir Avan, Majid Ghayour-Mobarhan
Vitamin D has an important role in bone metabolism but recently has been recognized as an immunoregulator, and this has led to investigations on the effect of Vitamin D supplementation in various autoimmune diseases and its anti-inflammatory effects. There is some evidence that Vitamin D can regulate gastrointestinal inflammation. In addition, previous studies have shown that Vitamin D can affect the gut microbiome. The aim of this review is to evaluate the effect of Vitamin D on inflammatory processes, especially its relation to the inflammatory bowel disease (IBD) and gut microbiome...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30173873/diet-during-pregnancy-and-infancy-and-the-infant-intestinal-microbiome
#5
Jessica H Savage, Kathleen A Lee-Sarwar, Joanne E Sordillo, Nancy E Lange, Yanjiao Zhou, George T O'Connor, Megan Sandel, Leonard B Bacharier, Robert Zeiger, Erica Sodergren, George M Weinstock, Diane R Gold, Scott T Weiss, Augusto A Litonjua
OBJECTIVES: To determine the association between diet during pregnancy and infancy, including breastfeeding vs formula feeding, solid food introduction, and the infant intestinal microbiome. STUDY DESIGN: Infants participating in the Vitamin D Antenatal Asthma Reduction Trial were included in this study (n = 323). Maternal and infant diets were assessed by questionnaire. Infant stool samples were collected at age 3-6 months. Stool sequencing was performed using the Roche 454 platform...
August 30, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30169457/dietary-vitamin-d-vitamin-d-receptor-and-microbiome
#6
Jun Sun
PURPOSE OF REVIEW: The current review is to summarize the recent progress of vitamin D/vitamin D receptor (VDR) and microbiome in intestinal homeostasis, airway function, and other organs. RECENT FINDINGS: Microbiome is considered as a newly discovered human organ. It is critical in the synthesis of vitamins and harvest of otherwise inaccessible nutrients, metabolism of xenobiotics, body fat storage, renewal of gut epithelial cells, and mature of immune system. Vitamin D and VDR are known to regulate microbiome in health and disease...
November 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/30121973/microglia-and-autism-spectrum-disorder-overview-of-current-evidence-and-novel-immunomodulatory-treatment-options
#7
REVIEW
Jung Won Kim, Ji Yeon Hong, Seung Min Bae
Autism spectrum disorder is a rapidly increasing heterogeneous neurodevelopmental syndrome, remarked by persistent deficit in social communication, and restricted, repetitive patterns of behavior and interest. Lately, maternal immune activation and micgroglial dysfunction in the developing brain have been gaining mounting evidence and leading to studies of various novel agents as potential treatment options. A few immunomodulatory treatment options-luteolin, minocycline, suramin, vitamin D, gut microbiota-are discussed in the current article, regarding the current understanding of their mechanisms and evidence for potential clinical use...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30031175/environmental-factors-gut-microbiota-and-colorectal-cancer-prevention
#8
REVIEW
Mingyang Song, Andrew T Chan
The substantial burden of colorectal cancer and increasing trend in young adults highlight the importance of lifestyle modification as a complement to screening for colorectal cancer prevention. Several dietary and lifestyle factors have been implicated in the development of colorectal cancer, possibly through the intricate metabolic and inflammatory mechanisms. Likewise, as a key metabolic and immune regulator, the gut microbiota has been recognized to play an important role in colorectal tumorigenesis. Increasing data support that environmental factors are crucial determinants for the gut microbial composition and function, whose alterations induce changes in the host gene expression, metabolic regulation, and local and systemic immune response, thereby influencing cancer development...
July 18, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29981368/mechanisms-of-action-of-vitamin-d-in-colon-cancer
#9
REVIEW
Gemma Ferrer-Mayorga, María Jesús Larriba, Piero Crespo, Alberto Muñoz
Colorectal cancer (CRC) is the neoplasia that is most frequently associated with vitamin D deficiency in epidemiological and observational studies in terms of incidence and mortality. Many mechanistic studies show that the active vitamin D metabolite (1α,25-dihydroxyvitamin D3 or calcitriol) inhibits proliferation and promotes epithelial differentiation of human colon carcinoma cell lines that express vitamin D receptor (VDR) via the regulation of a high number of genes. A key action underlining this effect is the multilevel inhibition of the Wnt/β-catenin signaling pathway, whose abnormal activation in colon epithelial cells initiates and promotes CRC...
July 4, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29972876/the-cotton-stainer-s-gut-microbiota-suppresses-infection-of-a-cotransmitted-trypanosomatid-parasite
#10
Thomas O Onchuru, Adam J Martinez, Martin Kaltenpoth
The evolutionary and ecological success of many insects is attributed to mutualistic partnerships with bacteria that confer hosts with novel traits including food digestion, nutrient supplementation, detoxification of harmful compounds and defence against natural enemies. Dysdercus fasciatus firebugs (Hemiptera: Pyrrhocoridae), commonly known as cotton stainers, possess a simple but distinctive gut bacterial community including B vitamin-supplementing Coriobacteriaceae symbionts. In addition, their guts are often infested with the intestinal trypanosomatid parasite Leptomonas pyrrhocoris (Kinetoplastida: Trypanosomatidae)...
July 4, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29960865/the-role-of-kidney-in-the-inter-organ-coordination-of-endogenous-glucose-production-during-fasting
#11
Keizo Kaneko, Maud Soty, Carine Zitoun, Adeline Duchampt, Marine Silva, Erwann Philippe, Amandine Gautier-Stein, Fabienne Rajas, Gilles Mithieux
OBJECTIVE: The respective contributions to endogenous glucose production (EGP) of the liver, kidney and intestine vary during fasting. We previously reported that the deficiency in either hepatic or intestinal gluconeogenesis modulates the repartition of EGP via glucagon secretion (humoral factor) and gut-brain-liver axis (neural factor), respectively. Considering renal gluconeogenesis reportedly accounted for approximately 50% of EGP during fasting, we examined whether a reduction in renal gluconeogenesis could promote alterations in the repartition of EGP in this situation...
June 18, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29950551/-body-weight-and-bone-calcium-metabolism-response-of-bone-metabolism-after-bariatric-surgery
#12
Takashi Yamaguchi, Atsuhito Saiki, Ichiro Tatsuno
While bariatric surgery is an effective treatment for severe obesity, these procedures may have unfavorable effects on bone and mineral metabolism. The most pronounced abnormalities are disorders of calcium/vitamin D metabolism, bone loss, as well as increased risk of bone fracture. These changes that occur after surgery vary by procedure type. Proposed mechanisms include skeletal unloading, malabsorption, secondary hyperparathyroidism and changes in gut hormones. This review explores bone response to bariatric surgery, potential mechanisms for these changes...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29939763/the-neurobiology-of-adaptation-to-seasons-relevance-and-correlations-in-bipolar-disorders
#13
Julia Maruani, George Anderson, Bruno Etain, Michel Lejoyeux, Frank Bellivier, Pierre A Geoffroy
Bipolar disorders (BDs) are severe and common psychiatric disorders. BD pathogenesis, clinical manifestations and relapses are associated with numerous circadian rhythm abnormalities. In addition, infradian fluctuations of mood, social activity, weight and sleep patterns are very frequent in BD. Disease course with a seasonal pattern (SP) occurs in approximately 25% of depressive and 15% of manic episodes, which is coupled to a more severe disease symptomatology. The pathophysiological mechanisms of seasonal effects in BD await clarification, with likely important clinical consequences...
June 25, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29886687/-effects-of-calcium-supplementation-during-the-pregnancy-and-early-infancy-stage-on-the-body-mass-index-and-gut-microbiota-in-the-infants
#14
X L Chang, Y Shang, Y J Liu, P Li, Y Y Wang, A M Liang, K M Qi
Objective: To investigate the effects of calcium supplementation during the pregnancy and early infancy stage on body mass index (BMI) and gut microbiota in the infants. Methods: A total of 1 752 healthy pregnant women and their infants (breast feeding) in two maternal and child health care hospitals of Beijing were chosen as the subjects in this study from May to October 2016. Questionnaires were used to obtain the general information and supplementation of calcium and vitamin D in mothers and their infants...
June 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29880619/small-intestinal-bacterial-overgrowth-sibo-and-vitamin-k-responsive-coagulopathy-a-previously-unrecorded-association
#15
Ricardo Brandt Oliveira, Ana Lourdes Candolo Martinelli, Luiz Ernesto Almeida Troncon, Jorge Elias
A 17-year-old woman, with a history of three operations on the upper gut in early life and intermittent diarrhoea, presented with a history of epistaxis and leg ecchymosis for the previous 3 months. Initial investigation revealed mild anaemia, low serum albumin, moderately elevated aminotransferases and an exceedingly prolonged prothrombin time (PT) which was promptly shortened to normal by intravenous vitamin K. Additional investigations revealed a grossly abnormal glucose hydrogen breath test, a dilated duodenum and deficiencies of vitamins A, D and E...
June 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29804586/vitamin-d-restricted-high-fat-diet-down-regulates-expression-of-intestinal-alkaline-phosphatase-isozymes-in-ovariectomized-rats
#16
Kanae Nakaoka, Asako Yamada, Seiko Noda, Masae Goseki-Sone
Intestinal alkaline phosphatase (IAP) is expressed at a high concentration in the brush border membrane of intestinal epithelial cells. Intestinal alkaline phosphatase controls bacterial endotoxin-induced inflammation by dephosphorylating lipopolysaccharide and is a gut mucosal defense factor. Previously, we reported that IAP activity in the duodenum was significantly decreased in male rats receiving a high-fat diet with vitamin D restriction. Here, we tested the hypothesis that IAP is also regulated by a vitamin D-restricted high-fat diet in an animal model of menopause...
May 2018: Nutrition Research
https://www.readbyqxmd.com/read/29766369/nutritional-issues-in-food-allergy
#17
REVIEW
Isabel J Skypala, Rebecca McKenzie
Diet and nutrition play an important role in the development and management of food allergy. The diet of expectant mothers can have an effect on their offspring in terms of allergic outcomes. A host of confounding factors may influence this, with a maternal diet rich in fruits and vegetables, fish, vitamin D-rich foods associated with a lower risk of allergic disease in their children. More surprisingly, the consumption of milk and butter has also been shown to have a protective effect, especially in a farm environment...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29762159/vitamin-d-in-inflammatory-bowel-disease-more-than-just-a-supplement
#18
John Gubatan, Alan C Moss
PURPOSE OF REVIEW: The aim of this review is to explore the protective role of vitamin D on the gastrointestinal tract, summarize the epidemiology of vitamin D deficiency in inflammatory bowel disease (IBD), and highlight recent studies examining the impact of low vitamin D and vitamin D supplementation on IBD clinical outcomes. RECENT FINDINGS: Vitamin D protects the gut barrier by regulating tight junction proteins and inhibiting intestinal apoptosis. Vitamin D enhances innate immunity by inducing antimicrobial peptides and regulates adaptive immunity by promoting anti-inflammatory T cells and cytokines...
July 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29754190/allergic-and-immunologic-perspectives-of-inflammatory-bowel-disease
#19
REVIEW
Kofi Clarke, Jayakrishna Chintanaboina
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial, and host factors including genetic factors, although the exact mechanism is not known. Dietary factors have been shown to play a role in the pathogenesis of IBD and can potentially alter the intestinal microbiota as well as disrupt the immune function in the gut...
May 12, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29693729/inflammatory-bowel-disease-and-immunonutrition-novel-therapeutic-approaches-through-modulation-of-diet-and-the-gut-microbiome
#20
REVIEW
Larissa S Celiberto, Franziska A Graef, Genelle R Healey, Else S Bosman, Kevan Jacobson, Laura M Sly, Bruce A Vallance
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, thought to at least in part reflect an aberrant immune response to gut bacteria. IBD is increasing in incidence, particularly in populations that have recently immigrated to western countries. This suggests that environmental factors are involved in its pathogenesis. We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D...
September 2018: Immunology
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