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Zhouyue Li, Yin Hu, Dongmei Cui, Wen Long, Mingguang He, Xiao Yang
PURPOSE: To investigate changes in subfoveal choroidal thickness (SFChT) during orthokeratology (Ortho-K) lens wear and after its cessation and the association of short-term change in SFChT with the long-term eye elongation in Ortho-K subjects. DESIGN: A prospective clinical trial. METHODS: Fifty myopic children aged between 9 and 14 years were enrolled. Twenty-nine subjects continuously wore Ortho-K lens for 12 months and discontinued for 1 month...
October 4, 2018: Acta Ophthalmologica
Massimo De Paschale, Maria Teresa Manco, Annalisa Cianflone, Luisa Belvisi, Debora Cagnin, Teresa Cerulli, Alessia Paganini, Carlo Agrappi, Paola Mirri, Pierangelo Clerici
BACKGROUND: Simultaneous detection of HIV 1 and 2 antibodies and HIV-1 p-24 antigen in the 4th generation tests is particularly effective for the identification of early acute HIV infections while maintaining accurate detection of long-established infections. OBJECTIVES: The aim of this study was to evaluate the new 4th generation VITROS HIV Combo test from Ortho-Clinical Diagnostics by comparing its results with those obtained using a 3rd generation HIV 1/2 antibody test (VITROS Anti HIV 1 + 2 from Ortho-Clinical Diagnostics) and a 4th generation test (LIAISON XL HIV Ab/Ag, DiaSorin) currently used in the Microbiology Unit of Legnano Hospital...
September 17, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Karl-Friedrich Krey, Anja Ratzmann, Philine Henriette Metelmann, Marcel Hartmann, Sebastian Ruge, Bernd Kordaß
OBJECTIVE: In most cases, according to our treatment concept, a presurgical orthodontic treatment (POT) is performed on patients with cleft lip and palate (CLP). The aim of this case report is to demonstrate a completely digital workflow for the production of a palate plate. MATERIALS AND METHODS: For the assessment of the maxillary arch, a digital impression of the jaw was made on two patients with an intraoral scanner (Cerec Omnicam Ortho). After reconstruction of a virtual model from the scan data, appropriate areas of the jaw could be blocked out and a plate constructed...
2018: International Journal of Computerized Dentistry
Seyed Amir Mousavi, Abbasali Khademi, Parisa Soltani, Shirin Shahnaseri, Marzie Poorghorban
Background: Adequate seal of the root canal is necessary to prevent recontamination and ensure the long-term clinical success. The aim of this study was to evaluate the sealing ability of ProRoot mineral trioxide aggregate (MTA), Biodentine, and Ortho MTA as the root canal obturation materials using the fluid infiltration method. Materials and Methods: In this invitro study a total of 66 extracted human mandibular premolars were randomly divided into five groups according to the material used for the root canal obturation...
September 2018: Dental Research Journal
Shu Yang, Jinping Hu, Yan Li, Zhigang Zhao
1. Bicyclol is a new synthetic anti-hepatitic drug and primarily metabolized by CYP3A. The aim of this study was to evaluate the pharmacokinetic interactions between bicyclol and co-administered drugs including metformin, pioglitazone, atorvastatin, fenofibrate, Cyclosporin A (CsA) and tacrolimus in rat and human liver microsomes (RLMs/HLMs) in vitro and in rats in vivo. 2. The depletion rate of bicyclol in RLMs was significantly inhibited by 44.8% and 35.5% after preincubation with pioglitazone and fenofibrate while the metabolite formation rate of bicyclol in HLMs was inhibited by 26...
September 14, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Sahitya Sanivarapu, Pavan Kumar Addanki, Rajababu Palaparty, Chaitanya Adurty
Periodontally accelerated osteogenic orthodontics (PAOO) is a clinical procedure that incorporates selective corticotomy, particulate grafting, and application of optimal orthodontic forces. It reduces treatment time, increases stability of teeth, and prevents relapse of orthodontic tooth movement (OTM). The present case report highlights the technique and principles of PAOO for rapid OTM.
September 2018: Journal of Indian Society of Periodontology
Jiang Jun, Bian Zhiwen, Wang Feifu, Lian Lili, Lu Fan
OBJECTIVES: To investigate the level of compliance with orthokeratology (ortho-k) guidelines and the main behaviors of poor compliance to guide clinical care. METHODS: A questionnaire was sent to ortho-k patients in the Eye Hospital of Wenzhou Medical University (EHWMU) in Mainland China who were prescribed ortho-k lenses after January 2013 and have worn ortho-k lenses for more than 1 year to determine the compliance rate for eight wear and care behaviors. Follow-up visit compliance was then investigated among these patients using a retrospective survey...
September 2018: Eye & Contact Lens
Francesco Castagnini, Barbara Bordini, Susanna Stea, Pierina Paola Calderoni, Claudio Masetti, Luca Busanelli
PURPOSE: Highly porous cups were developed to improve osseointegration and reduce the rate of aseptic loosening. Highly porous titanium cups could mix the reliability of titanium metal with an enhanced porosity, improving the bony ingrowth. The aim of this report was to assess the survival rates and reasons for revision of a highly porous titanium cup, Fixa Ti-Por (Adler Ortho, Milan, Italy), fabricated using an additive manufacturing. METHODS: The Registry of Prosthetic Orthopedic Implants (RIPO), the Emilia-Romagna region arthroplasty registry, was enquired about cementless cups, implanted since July 2007...
August 23, 2018: International Orthopaedics
Lokesh Kumar Sharma, Deep Dutta, Neera Sharma, Bhaskar Thakur
BACKGROUND: No data is available evaluating the difference in serum versus plasma sample assay of commonly tested parameters in the emergency department, where the sample processing time can be significantly reduced if plasma is used for analysis instead of conventionally used serum. Hence, this study aimed to evaluate the differences in serum versus plasma sample estimation of commonly evaluated biochemical parameters using dry chemistry technology. MATERIALS AND METHODS: Paired blood samples were collected from a single venipuncture of 405 patients admitted to the emergency department...
July 2018: Journal of Laboratory Physicians
Chandrasekhar Challa, Jaice Ravindran, Mohini Mohan Konai, Sunil Varughese, Jubi Jacob, B S Dileep Kumar, Jayanta Haldar, Ravi S Lankalapalli
Easily accessible 3,3'-diindolylmethanes (DIMs) were utilized to generate a focused library of indolo[2,3- b ]quinolines ( 2 ), chromeno[2,3- b ]indoles ( 3 ), and 3-alkenyl-oxindoles ( 4 ) under 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated oxidative conditions. DIMs with ortho-NHTosyl (NHTs) phenyl group afforded indolo[2,3- b ]quinolines ( 2 ), whereas DIMs with ortho-hydroxy phenyl groups yielded chromeno[2,3- b ]indoles ( 3 ) and 3-alkenyl-oxindoles ( 4 ). The mild conditions and excellent yields of the products make this method a good choice to access a diverse library of bioactive molecules from a common starting material...
August 31, 2017: ACS Omega
Steven R Feldman, Shipra Rastogi, Jay Lin
INTRODUCTION: Clinical trials have shown brodalumab to have better efficacy than ustekinumab for the treatment of moderate-to-severe psoriasis. An estimation of the cost-effectiveness of brodalumab vs. ustekinumab is warranted and may be useful for treatment decision-making processes, especially in the context of the cost considerations of the current US healthcare system. Therefore, we compared the cost-effectiveness of brodalumab with ustekinumab for treatment of moderate-to-severe psoriasis in biologic-naïve and biologic-experienced patients in the USA...
July 13, 2018: Dermatology and Therapy
Gabriela Cristina Santin, Alexandra Mussolino de Queiroz, Regina Guenka Palma-Dibb, Harley Francisco de Oliveira, Paulo Nelson Filho, Fábio Lourenço Romano
Patients undergoing radiotherapy treatment present more susceptibility to dental caries and the use of an orthodontic device increases this risk factor due to biofilm accumulation around the brackets. The objective of this study was to evaluate the shear bond strength to irradiated permanent teeth of orthodontic brackets bonded with conventional glass ionomer cement and resin-modified glass ionomer cement due to the fluoride release capacity of these materials. Ninety prepared human premolars were divided into 6 groups (n=15), according to the bonding material and use or not of radiation: CR: Transbond XT composite resin; RMGIC: Fuji Ortho LC conventional glass ionomer cement; GIC: Ketac Cem Easymix resin-modified glass ionomer cement...
March 2018: Brazilian Dental Journal
M Mukhlesur Rahman, Winnie K P Shiu, Simon Gibbons, John P Malkinson
Bioassay-directed drug discovery efforts focusing on various species of the genus Hypericum led to the discovery of a number of new acylphloroglucinols including (S,E)-1-(2-((3,7-dimethylocta-2,6-dien-1-yl)oxy)-4,6-dihydroxyphenyl)-2-methylbutan-1-one (6, olympicin A) from H. olympicum, with MICs ranging from 0.5 to 1 mg/L against a series of clinical isolates of multi-drug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains. The promising activity and interesting chemistry of olympicin A prompted us to carry out the total synthesis of 6 and a series of analogues in order to assess their structure-activity profile as a new group of antibacterial agents...
July 15, 2018: European Journal of Medicinal Chemistry
Fernando André Barth, Angelo Menuci Melo, Renata Rodrigues Almeida-Pedrin, Victor de Miranda Ladewig, Ana Cláudia de Castro Ferreira Conti
Cleidocranial dysostosis (CCD) is a congenital skeletal disorder with significant manifestations in facial and dental development. Patients are affected with CCD present maxillary deficiency, late dental eruption, and supernumerary teeth. Early and multidisciplinary approach is necessary to treat CCD patients, especially to manage dental eruption and Class III malocclusion with maxillary deficiency. Several orthodontic and surgical interventions are performed to enable traction and extraction of teeth. Yet the maxillary deficiency may be protracted followed by orthodontic dental compensation...
June 5, 2018: Journal of Craniofacial Surgery
Sandra Isabel Jiménez-Gayosso, Edith Lara-Carrillo, Saraí López-González, Carlo Eduardo Medina-Solís, Rogelio José Scougall-Vilchis, César Tadeo Hernández-Martínez, Gabriel Eduardo Colomé-Ruiz, Mauricio Escoffié-Ramirez
The objective of this study was to compare the differences between the measurements performed manually to those obtained using a digital model scanner of patients with orthodontic treatment.A cross-sectional study was performed in a sample of 30 study models from patients with permanent dentition who attended a university clinic between January 2010 and December 2015. For the digital measurement, a Maestro 3D Ortho Studio scanner (Italy) was used and Mitutoyo electronic Vernier calipers (Kawasaki, Japan) were used for manual measurement...
June 2018: Medicine (Baltimore)
Maria Francesca Sfondrini, Paola Gandini, Maurizio Malfatto, Francesco Di Corato, Federico Trovati, Andrea Scribante
Introduction: Intraoral scanners allow direct images of oral situation, with fewer steps than conventional impressions. The purpose of this study was to compare the accuracy of digital impressions, traditional impressions, and digitalization of full-arch gypsum models, to evaluate timing of different methods and finally to study perception of patients about conventional and digital impression techniques. Methods: Dental arches of fourteen patients were evaluated by alginate impression, titanium dioxide powder-free intraoral scanning (Trios, 3Shape), and digitalization obtained from gypsum models using the same scanner...
2018: BioMed Research International
Daozhong Zhang, Zhijun Tang, Wen Liu
Natural products typically are small molecules produced by living organisms. These products possess a wide variety of biological activities and thus have historically played a critical role in medicinal chemistry and chemical biology either as chemotherapeutic agents or as useful tools. Natural products are not synthesized for use by human beings; rather, living organisms produce them in response to various biochemical processes and environmental concerns, both internal and external. These processes/concerns are often dynamic and thus motivate the diversification, optimization, and selection of small molecules in line with changes in biological function...
June 19, 2018: Accounts of Chemical Research
Jie Zang, Xuewu Liang, Yongxue Huang, Yuping Jia, Xiaoyang Li, Wenfang Xu, C James Chou, Yingjie Zhang
Herein a novel series of pazopanib hybrids as polypharmacological antitumor agents were developed based on the crosstalk between histone deacetylases (HDACs) and vascular endothelial growth factor (VEGF) pathway. Among them, one ortho-aminoanilide 6d and one hydroxamic acid 13f exhibited considerable total HDACs and VEGFR-2 inhibitory activities. The HDAC inhibitory activities endowed 6d and 13f with potent antiproliferative activities, which was not observed in the approved VEGFR inhibitor pazopanib. Compounds 6d and 13f possessed comparable HDAC isoform selectivity profiles to the clinical class I HDAC inhibitor MS-275 and the approved pan-HDAC inhibitor SAHA, respectively...
June 28, 2018: Journal of Medicinal Chemistry
Jesse A Dorchak, Sifat Maria, Joseph L Guarinoni, Anette Duensing, Stella Somiari, Jane Cavanaugh, Brenda Deyarmin, Hai Hu, Joji Iida, Craig D Shriver, Paula A Witt-Enderby
This retrospective case series study, using data obtained through questionnaires and histopathological diagnoses from 656 patients enrolled in the Department of Defense (DoD) Clinical Breast Care Project (CBCP), evaluated associations between hormonal contraceptive use and breast cancer pathology including benign breast pathologies. Three combination hormonal contraceptive agents (COCs) Lo Ovral (LO), Ortho Novum (ON), and Ortho Tri-Cyclen (OTC) were evaluated as they represented the most commonly used hormonal contraceptives in our cohort...
August 2018: Hormones & Cancer
William McKeand, Susan Baird-Bellaire, James Ermer, Alain Patat
An open-label, 3-period study was conducted in 30 healthy postmenopausal women (mean age, 58.4 years) who received a single oral dose of atorvastatin 20 mg on day 1 (period 1), multiple daily dosing of bazedoxifene 40 mg on days 4-11 (period 2), and coadministration of atorvastatin 20 mg + bazedoxifene 40 mg on day 12 (period 3). Serial blood samples were collected (24 hours after bazedoxifene and 72 hours after atorvastatin) and assayed for bazedoxifene, atorvastatin, and its ortho-hydroxy and para-hydroxy metabolites...
April 23, 2018: Clinical Pharmacology in Drug Development
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