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Monitoring of diabetes treatment

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https://www.readbyqxmd.com/read/30642746/optimization-of-insulin-regimen-and-glucose-outcomes-with-short-term-real-time-continuous-glucose-monitoring-rt-cgm-in-type-1-diabetic-children-with-sub-optimal-glucose-control-on-multiple-daily-injections-the-pediatric-diaccor-study
#1
S Picard, E Bonnemaison-Gilbert, E Leutenegger, P Barat
BACKGROUND: The impact of 7-day real-time continuous glucose monitoring (RT-CGM) on type 1 diabetes (T1D) management remains unknown in youths with suboptimal control by multiple daily injections (MDI). The DIACCOR Study aimed to describe treatment decisions and glucose outcomes after a short-term RT-CGM sequence in real-life conditions. METHODS: This French multicenter longitudinal observational study included T1D youths with HbA1c>7.5% or a history of severe hypoglycemia (SH) or recurrent documented hypoglycemia...
January 12, 2019: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/30641796/the-morphofunctional-features-of-platelets-against-the-background-of-metabolic-syndrome-in-patients-with-generalized-marginal-periodontitis
#2
Yu L Vasil'ev, O V Kytko, N S Smetneva, I V Goloborodova, M V Nelipa
According to modern ideas, disorders in the system of hemostasis in cardiovascular diseases are mainly due to an increase in the functional activity of platelets, namely their increased ability to adhere and aggregate. Aim of the research was to evaluate morphofunctional platelets of patients with marginal periodontitis. Material and methods of the study involved 129 men aged 28-50 years (mean age 42.97 ± 1.31 years) suffering from a MS with generalized periodontitis of mild and moderate degree. We also formed a control group of 90 practically healthy men (mean age 42...
January 2019: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30640363/association-of-tourette-syndrome-and-chronic-tic-disorder-with-metabolic-and-cardiovascular-disorders
#3
Gustaf Brander, Kayoko Isomura, Zheng Chang, Ralf Kuja-Halkola, Catarina Almqvist, Henrik Larsson, David Mataix-Cols, Lorena Fernández de la Cruz
Importance: There are limited data concerning the risk of metabolic and cardiovascular disorders among individuals with Tourette syndrome (TS) or chronic tic disorder (CTD). Objective: To investigate the risk of metabolic and cardiovascular disorders among individuals with TS or CTD over a period of 40 years. Design, Settings, and Participants: This longitudinal population-based cohort study included all individuals living in Sweden between January 1, 1973, and December 31, 2013...
January 14, 2019: JAMA Neurology
https://www.readbyqxmd.com/read/30640078/comparison-of-outcomes-and-costs-between-adult-diabetic-ketoacidosis-patients-admitted-to-the-icu-and-step-down-unit
#4
Shannon M Fernando, Sean M Bagshaw, Bram Rochwerg, Daniel I McIsaac, Kednapa Thavorn, Alan J Forster, Alexandre Tran, Peter M Reardon, Erin Rosenberg, Peter Tanuseputro, Kwadwo Kyeremanteng
PURPOSE: There is wide variation in the utilization of Intensive Care Unit (ICU) beds for treatment and monitoring of adult patients with Diabetic Ketoacidosis (DKA). We sought to compare the outcomes and hospital costs of adult DKA patients admitted to ICUs as compared to those admitted to step-down units. MATERIALS AND METHODS: We included consecutive adult patients from two hospitals with a diagnosis of DKA. Patients were either admitted to the ICU, or a step-down unit, which has a nurse-to-patient ratio of 2:1, but does not have capability for mechanical ventilation or administration of vasoactive agents...
December 25, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/30636266/incipient-albuminuria-in-persons-with-newly-diagnosed-type-2-diabetes-mellitus-a-5-year-retrospective-cohort-study
#5
Shermin Tan, Lai Yin Wong, Matthias Paul Hs Toh
INTRODUCTION: This study aimed to determine the 5-year incidence of albuminuria among Asian persons with newly diagnosed type 2 diabetes mellitus (DM), and to identify the risk factors at diagnosis for progression to albuminuria. MATERIALS AND METHODS: A retrospective 5-year closed cohort study was conducted among 1016 persons aged ≥18 years old who were diagnosed with type 2 DM between 1 January 2007 and 31 December 2009 at primary care facilities in Singapore...
December 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/30631793/impact-of-diabetes-mellitus-on-the-presentation-and-response-to-treatment-of-adults-with-pulmonary-tuberculosis-in-qatar
#6
Khalid M Dousa, Abdelrahman Hamad, Mohamed Albirair, Hussam Al Soub, Abdel-Naser Elzouki, Mahmoud I Alwakeel, Bonnie A Thiel, John L Johnson
Background: Persons with diabetes mellitus (DM) have a 3-fold increased risk of tuberculosis (TB). Atypical radiographic findings and differences in bacteriologic response during anti-TB treatment have been reported in earlier studies; however, the findings have varied. We evaluated the effect of DM on manifestations and response to treatment in adults with pulmonary TB in Qatar. Methods: The impact of DM on the clinical and radiographic presentations of pulmonary TB and bacteriologic response during anti-TB treatment was evaluated between January 2007 and December 2011, comparing patients with and without DM...
January 2019: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/30630990/the-emergence-of-non-communicable-disease-in-indonesia
#7
Dyah Purnamasari
Based on data from the Indonesian Ministry of Health Information Center, the estimated population of Indonesia in 2016 was approximately 258,704,986 people, consisted of 129,988,690 men and 128,716,296 women. This number of Indonesian population represents young population since the proportion of population aged 0-14 years is more than that aged >14 years. Meanwhile, the proportion of population aged 50 years and above is significantly reduced, which is thought to be due to high mortality rate in the middle-aged population...
October 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/30630669/prevalence-of-diabetes-and-frequency-of-glycated-haemoglobin-monitoring-in-extremadura-spain-during-2012-2013-and-2014-an-observational-study
#8
Alfonso Barquilla García, Javier Sánchez Vega, Juan Carlos Romero Vigara, Leandro Fernández, María José Gamero Samino, Francisco Buitrago
AIMS: To analyze the prevalence of diabetes and the frequency of haemoglobin A1C (HbA1C ) monitoring in the population with diabetes in Extremadura (Spain). METHODS: Observational, longitudinal retrospective study in the population attended in the Extremadura Health System in 2012-2014. A total of 403,644 glycated haemoglobin determinations in 189,466 subjects (52.4% female) were studied. All patients with a prescription of antidiabetic drugs and those who, despite not having treatment, had any determination of HbA1C ≥6...
January 7, 2019: Primary Care Diabetes
https://www.readbyqxmd.com/read/30626749/the-antianginal-ranolazine-mitigates-obesity-induced-nonalcoholic-fatty-liver-disease-and-increases-hepatic-pyruvate-dehydrogenase-activity
#9
Rami Al Batran, Keshav Gopal, Hanin Aburasayn, Amina Eshreif, Malak Almutairi, Amanda A Greenwell, Scott A Campbell, Bruno Saleme, Emily A Court, Farah Eaton, Peter E Light, Gopinath Sutendra, John R Ussher
Obese individuals are often at risk for nonalcoholic fatty liver disease (NAFLD), insulin resistance, type 2 diabetes (T2D), and cardiovascular diseases such as angina, thereby requiring combination therapies for their comorbidities. Ranolazine is a second-line antianginal agent that also improves glycemia, and our aim was to determine whether ranolazine modifies the progression of obesity-induced NAFLD. Twelve-week-old C57BL/6J male mice were fed a low-fat or high-fat diet for 10 weeks and then treated for 30 days with either vehicle control or ranolazine (50 mg/kg via daily s...
January 10, 2019: JCI Insight
https://www.readbyqxmd.com/read/30626566/a-mobile-phone-based-program-to-promote-healthy-behaviors-among-adults-with-prediabetes-who-declined-participation-in-free-diabetes-prevention-programs-mixed-methods-pilot-randomized-controlled-trial
#10
Dina Griauzde, Jeffrey T Kullgren, Brad Liestenfeltz, Tahoora Ansari, Emily H Johnson, Allison Fedewa, Laura R Saslow, Caroline Richardson, Michele Heisler
BACKGROUND: Despite evidence that Diabetes Prevention Programs (DPPs) can delay or prevent progression to type 2 diabetes mellitus (T2DM), few individuals with prediabetes enroll in offered programs. This may be in part because many individuals with prediabetes have low levels of autonomous motivation (ie, motivation that arises from internal sources) to prevent T2DM. OBJECTIVE: This study aims to examine the feasibility and acceptability of a mobile health (mHealth) intervention designed to increase autonomous motivation and healthy behaviors among adults with prediabetes who previously declined participation free DPPs...
January 9, 2019: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/30621663/enhancement-of-postprandial-endogenous-insulin-secretion-rather-than-exogenous-insulin-injection-ameliorated-insulin-antibody-induced-unstable-diabetes-a-case-report
#11
Keizo Kaneko, Chihiro Satake, Tomohito Izumi, Mamiko Tanaka, Junpei Yamamoto, Yoichiro Asai, Shojiro Sawada, Junta Imai, Tetsuya Yamada, Hideki Katagiri
BACKGROUND: Insulin injection, especially with insulin analogs, occasionally induces the production of insulin antibodies with high binding capacity and low affinity, similar to the insulin autoantibodies characteristic of insulin autoimmune syndrome (IAS). Production of these "IAS-like" insulin antibodies causes marked glycemic fluctuations with postprandial hyperglycemia and fasting hypoglycemia. CASE PRESENTATION: A 66-year-old man with a 27-year history of diabetes was admitted because of marked glycemic fluctuations...
January 8, 2019: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/30619717/improvement-of-glycemic-control-by-treatment-for-insomnia-with-suvorexant-in-type-2-diabetes-mellitus
#12
Norikazu Toi, Masaaki Inaba, Masafumi Kurajoh, Tomoaki Morioka, Noriyuki Hayashi, Tomoe Hirota, Daichi Miyaoka, Masanori Emoto, Shinsuke Yamada
Introduction: Acute and chronic insomnia can exacerbate type 2 diabetes mellitus (T2DM). We investigated suvorexant (an anti-insomnia drug that targets the orexin system) effects on sleep architecture and glucose metabolism in T2DM patients with insomnia. Materials and methods: This 7 day open-label, single-arm, intervention trial included 18 subjects with T2DM and insomnia. After 1 day acclimatization, daily glucose levels, sleep architecture, and autonomic nervous function were evaluated by continuous glucose monitoring (CGM), single-channel electroencephalography, and accelerometry, respectively...
March 2019: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/30616618/disruption-of-the-hippocampal-and-hypothalamic-blood-brain-barrier-in-a-diet-induced-obese-model-of-type-ii-diabetes-prevention-and-treatment-by-the-mitochondrial-carbonic-anhydrase-inhibitor-topiramate
#13
Therese S Salameh, William G Mortell, Aric F Logsdon, D Allan Butterfield, William A Banks
BACKGROUND: Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood-retinal barrier (BRB) and blood-brain barrier (BBB) are hallmarks of subsequent retinal edema and central nervous system dysfunction. However, the mechanisms by which diet or metabolic syndrome induces dysfunction are not understood. A proposed mechanism is an increase in reactive oxygen species (ROS) and oxidative stress. Inhibition of mitochondrial carbonic anhydrase (mCA) decreases ROS and oxidative stress...
January 8, 2019: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/30614187/association-of-high-circulating-testosterone-with-increased-glycemic-variability-in-patients-with-type-2-diabetes-a-cross-sectional-study-in-china
#14
Bo Ding, Rui Sun, Xiao-Fang Zhai, Ting-Ting Lu, Liang Cheng, Feng-Fei Li, Yun Hu, Jian-Hua Ma
BACKGROUND: Testosterone affects insulin resistance, but the effect of testosterone treatment on type 2 diabetes (T2D) remains controversial. We aimed to investigate the association between circulating total testosterone (TT) and glycemic variability using continuous glucose monitoring (CGM) in patients with T2D. MATERIALS AND METHODS: A total of 248 men with T2D were finally enrolled in the study. Clinical characteristics and plasma for glycated hemoglobin (HbA1c) and C-peptide assessment were collected...
January 6, 2019: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30608534/how-to-position-pasireotide-lar-treatment-in-acromegaly
#15
Eva C Coopmans, Ammar Muhammad, Aart-Jan van der Lely, Joseph A M J L Janssen, Sebastian J C M M Neggers
Context: Pasireotide long-acting release (LAR) is a somatostatin multi-receptor ligand and in the current consensus criteria pasireotide LAR is considered the second-line medical treatment of acromegaly. We present in this paper our recommendations to define the position of pasireotide LAR in the treatment of acromegaly and provide recommendations for the management of pasireotide-induced hyperglycemia. Evidence acquisition: Our recommendations are based on our experiences with the pasireotide LAR and pegvisomant (PEGV) combination study and the available basic or clinical papers published in peer-reviewed international journals on pasireotide LAR and acromegaly...
January 3, 2019: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30608337/efficacy-of-maggot-therapy-on-staphylococcus-aureus-and-pseudomonas-aeruginosa-in-diabetic-foot-ulcers-a-randomized-controlled-trial
#16
Azam Malekian, Gholamreza Esmaeeli Djavid, Kamran Akbarzadeh, Mehdi Soltandallal, Yavar Rassi, Javad Rafinejad, Abbas Rahimi Foroushani, Amirreza Farhoud, Ronak Bakhtiary, Mehrangiz Totonchi
PURPOSE: This study was conducted to evaluate the antimicrobial effects of medicinal maggots of Lucilia sericata on Staphylococcus aureus and Pseudomonas aeruginosa on diabetic foot ulcers (DFUs). DESIGN: Randomized controlled trial. SUBJECTS AND SETTING: The sample comprised 50 adult patients from the clinic of the Academic Center for Education, Culture and Research of Tehran University of Medical Sciences, Iran. All participants who had at least 1 DFU present for at least 12 weeks, an arterial brachial index value of more than 0...
January 2019: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/30608045/role-of-nanotechnology-in-diabetic-management
#17
Reena Siwach, Parijat Pandey, Viney Chawla, Harish Dureja
BACKGROUND: Diabetes Mellitus (DM) has emerged as an epidemic that has affected millions of people worldwide in the last few decades. Nanotechnology is a discipline that is concerned with material characteristics at nanoscale and offers novel techniques for disease detection, management and prevention. OBJECTIVE: Diabetes mellitus is an epidemic disease that has affected millions of people globally. Nanotechnology has greatly enhanced the health status by providing non-obtrusive techniques for the management and treatment of diabetic patients...
January 4, 2019: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/30606312/clinical-management-of-combined-tuberculosis-and-diabetes
#18
R van Crevel, R Koesoemadinata, P C Hill, A D Harries
Optimal management of combined tuberculosis (TB) and diabetes (DM) is important but challenging in terms of achieving good disease outcomes and avoiding toxicity, drug interactions and other challenges. DM management during anti-tuberculosis treatment, aimed at improving TB treatment outcomes and reducing DM-related morbidity and mortality, consists of glycaemic control and measures to reduce the risk of cardiovascular disease. Metformin, the glucose-lowering drug of choice for TB patients, has no meaningful interaction with rifampicin (RMP), and may reduce TB mortality...
December 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30605901/oral-litholysis-in-patients-with-chronic-calcific-pancreatitis-unresponsive-to-or-ineligible-for-extracorporeal-shock-wave-lithotripsy-and-endoscopic-therapy
#19
Koichi Hamano, Aiji Noda, Eri Ibuki, Nobuo Ashizawa, Shunsuke Inamoto, Junko Izumi, Jun Usami, Hiroaki Nakagawa, Yoshinori Wakita, Masato Maekawa
BACKGROUND/AIMS: Our study aimed to evaluate the effect of oral litholysis in patients with chronic calcific pancreatitis (CCP) unresponsive to or ineligible for extracorporeal shock wave lithotripsy (ESWL) and endoscopic therapy. METHODS: Trimethadione, an antiepileptic agent, was administered orally at a dose of 0.6-0.9 g/day to 15 patients with this condition. Treatment outcome was evaluated by assessment of dissolution of the pancreatic stones on plain X-ray films and computed tomography scans of the upper abdomen...
January 3, 2019: Digestion
https://www.readbyqxmd.com/read/30605054/hyperglycemia-and-diabetes-induced-by-glucocorticoids-in-nondiabetic-and-diabetic-patients-revision-of-literature-and-personal-considerations
#20
Ceccarelli Elena, Mattaliano Chiara, Brazzi Angelica, Marinetti Adriana Chiara, Nigi Laura, Chirico Chiara, Corallo Claudio, Fioravanti Antonella, Giordano Nicola
BACKGROUND: Glucocorticoids are powerful and effective anti-inflammatory and immunosuppressive drugs. They have a wide use in the treatment of different diseases, even though their side effects, such as hypertension, osteoporosis and, in particular, diabetes, are well known. They can exacerbate hyperglycemia in patients with diabetes mellitus or facilitate the development of a metabolic disease in apparently healthy subjects, the so called steroid-induced diabetes mellitus. This last is an independent risk factor for other complications associated with the use of glucocorticosteroids...
January 2, 2019: Current Pharmaceutical Biotechnology
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