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Yuxun Zhou, Li Tong, Maochun Wang, Xueying Chang, Sijia Wang, Kai Li, Junhua Xiao
Puberty onset is a complex trait regulated by multiple genetic and environmental factors. In this study, we narrowed a puberty related QTL region down to a 1.7 Mb region on chromosome X in female mice and inferred miR-505-3p as the functional gene. We conducted ectopic expression of miR-505-3p in the hypothalamus of prepubertal female mice through lentivirus-mediated orthotopic injection. The impact of miR-505-3p on female puberty was evaluated by the measurement of pubertal/reproduction events and histological analysis...
December 1, 2018: Journal of Endocrinology
Huiying Zhang, Huixia Zhang, Xueqing He, Wenyan Tian, Xueru Song
Endometrial polyps are frequently encountered in the uterine cavity of infertile women. There is much debate regarding the treatment of endometrial polyps in patients who are undergoing assisted reproductive technology (ART). A systematic review was performed by searching PubMed, Embase, and the Cochrane Library for retrospective or prospective studies that compared the effect of hysteroscopic resection of polyps with no treatment on pregnancy outcomes of patients who underwent ART. Primary outcomes were clinical pregnancy, live birth, miscarriage, and implantation rate after ART...
December 14, 2018: Journal of Minimally Invasive Gynecology
Yu-Jin Jo, In-Won Lee, Seung-Min Jung, JeongWoo Kwon, Nam-Hyung Kim, Suk Namgoong
Zinc plays an essential role in mammalian oocyte maturation, fertilization, and early embryogenesis, and depletion of zinc impairs cell cycle control, asymmetric division, and cytokinesis in oocyte. We report that zinc, via the actin nucleator Spire, acts as an essential regulator of the actin cytoskeleton remodeling during mouse oocyte maturation and fertilization. Depletion of zinc in the mouse oocyte impaired cortical and cytoplasmic actin formation. Spire is colocalized with zinc-containing vesicles via its zinc finger-containing Fab1, YOTB, Vac 1, EEA1 (FYVE) domain...
December 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Vahid Zadmajid, Sune Riis Sørensen, Ian Anthony Ernest Butts
Levantine scraper, Capoeta damascina is a candidate species for future stock assessments, conservation studies, and hatchery efforts. Herein, we documented embryonic and early larval development, from egg activation to the exogenous feeding period, using morphological and histological landmarks. Embryos were obtained by in vitro fertilization from hormonally induced wild-caught broodstock, and subsequent development was monitored at temperatures coinciding with native conditions. Embryonic development from fertilization to hatch lasted ~105-110 hr...
January 2019: Journal of Morphology
Rogelio Díaz-Méndez, Guido Pupillo, Fabio Mezzacapo, Mats Wallin, Jack Lidmar, Egor Babaev
We present a new type of phase-change behavior relevant for information storage applications, that can be observed in 2D systems with cluster-forming ability. The temperature-based control of the ordering in 2D particle systems depends on the existence of a crystal-to-glass transition. We perform molecular dynamics simulations of models with soft interactions, demonstrating that the crystalline and amorphous structures can be easily tuned by heat pulses. The physical mechanism responsible for this behavior is a self-assembled polydispersity, that depends on the cluster-forming ability of the interactions...
December 17, 2018: Soft Matter
József Bódis, Endre Sulyok, Tamás Kőszegi, Krisztina Gödöny, Viktória Prémusz, Ákos Várnagy
OBJECTIVE: This observational, clinical study was designed to assess the role of sirtuin 1 (SIRT1), sirtuin 6 (SIRT6), and resveratrol in in vitro fertilization (IVF). METHODS: Paired serum and follicular fluid (FF) samples were obtained from 30 consecutive patients (age: 36.43 ± 4.17 years, body mass index: 22.90 ± 2.05 kg/m2 , duration of infertility: 5.10 ± 2.80 years) who received IVF treatment. SIRT1, SIRT6, and resveratrol levels were measured by enzyme-linked immunosorbent assay...
December 16, 2018: Journal of International Medical Research
Stephanie E Lessing, Laura L Hayman
BACKGROUND: Diabetes treatment and management provide a unique opportunity for examination of the effectiveness of electronic health records (EHRs) on patient health outcomes, continuity of care, and areas for further development. This systematic literature review was designed to identify the strengths and limitations of EHR and opportunities for improvement proposed in original research and recent rigorous systematic reviews. METHODS: This review utilized methodology adapted from PRISMA...
December 17, 2018: Journal of Diabetes Science and Technology
Lindsay Jasperse, Milton Levin, Kara Rogers, Christopher Perkins, Thijs Bosker, Robert J Griffitt, Maria S Sepúlveda, Sylvain De Guise
The Deepwater Horizon (DWH) oil spill resulted in the release of over 640 million liters of crude oil into the Gulf of Mexico (GOM), affecting over 2,000 kilometers of shoreline, including estuaries that serve as important habitats and nurseries for aquatic species. Cyprinodon variegatus (sheepshead minnow; SHM) are small-bodied fish that inhabit northern GOM estuaries, are easily adaptable to laboratory conditions, and are commonly used in toxicological assessment studies. The purpose of this study was to determine the somatic, reproductive, and developmental effects of an environmentally relevant polycyclic aromatic hydrocarbon (PAH) mixture, the oil high-energy water accommodated fraction (HEWAF), on experimentally exposed SHM (F0 ), as well as two generations of offspring (F1 and F2 ) without additional exposure...
December 17, 2018: Environmental Toxicology and Chemistry
Zengxiang Ge, Alice Y Cheung, Li-Jia Qu
Unlike in animals, sperm in flowering plants are immotile and they are embraced as passive cargoes by a pollen tube which embarks on a long journey in the pistil to deliver them to the female gametophyte for fertilization. How the pollen tube switches from a rapid polarized growth towards its target to an abrupt disintegration for sperm cell release inside the female gametophyte has been puzzling. Recent studies showed that members of the Catharanthus roseus RLK1-like (CrRLK1L) receptor kinase family and their ligands, 5-kDa cysteine-rich peptides rapid alkalinization factors (RALFs), engage in an intricate balancing act involving autocrine and paracrine signaling to maintain pollen tube growth and induce timely tube rupture at the spatially confined pollen tube-female gametophyte interface...
December 16, 2018: New Phytologist
Mohammad Sadegh Sabet, Katayoun Zamani, Tahmineh Lohrasebi, Mohammad Ali Malboobi, Mostafa Valizadeh
Background: Overexpression of known genes encoding key phosphate (Pi)-metabolizing enzymes, such as acid phosphatases (APases), is presumed to help plants with Pi availability and absorption as they are mostly exposed to suboptimal environmental conditions for this vital element. Objectives: In this study, the overexpression effect of AtPAP26 , one of the main contributors in retrieving Pi from intracellular and extracellular compounds, was evaluated from various viewes in tobacco plant...
April 2018: Iranian Journal of Biotechnology
Malihezaman Monsefi, Bahareh Khalifeh, Samaneh Nikeghbal
Background: According to previous studies, Anethum graveolens L. (dill) aqueous extracts decreased the fertility of female rats. Therefore, the present study aimed to examine the effects of this herb on cultured granulosa cells and immature oocytes. Methods: The cells were obtained from 27-29 day immature superovulated mice. The oocytes were cultured in a petri dish consisting of 30 μl drops of MEM-α and granulosa cells in a 24-well plate consisting of DMEM/F12 and different concentrations of 0, 10, 50, 100, 500, 1000, 10000 μg/ml of dill seed aqueous extract (DSAE) in 37° C and 5% CO2 ...
October 2018: Avicenna Journal of Medical Biotechnology
Saya Kishimoto, Masaharu Uno, Eisuke Nishida
Throughout life, organisms are subjected to a variety of environmental perturbations, including temperature, nutrient conditions, and chemical agents. Exposure to external signals induces diverse changes in the physiological conditions of organisms. Genetically identical individuals exhibit highly phenotypic variations, which suggest that environmental variations among individuals can affect their phenotypes in a cumulative and inhomogeneous manner. The organismal phenotypes mediated by environmental conditions involve development, metabolic pathways, fertility, pathological processes, and even lifespan...
2018: Inflammation and Regeneration
Falong Hu, Yan Tan, Aizhong Yu, Cai Zhao, Jeffrey A Coulter, Zhilong Fan, Wen Yin, Hong Fan, Qiang Chai
Sustainable intensification of pulses needs reduced input of nitrogen (N) fertilizer with enhanced crop nutritional quality and yield. Therefore, increasing N harvest in grains (sink organs) by improving N remobilization is of key importance. Previous research has shown that a lower dose of N fertilizer effectively increases the rate of N remobilization, while intercropping improves the grain N concentration in pea ( Pisum sativum L.). However, it is unknown whether intercropping can facilitate this N fertilizer effect to increase N remobilization, and thereby enhance the N harvest index (NHI)...
2018: Frontiers in Plant Science
Antonella Camaioni, Francesca Gioia Klinger, Luisa Campagnolo, Antonietta Salustri
Follicular development is a highly coordinated process that in humans takes more than 6 months. Pituitary gonadotropins and a variety of locally produced growth factors and cytokines are involved in determining a precise sequence of changes in cell metabolism, proliferation, vascularization, and matrix remodeling in order to obtain a follicle with full ovulatory and steroidogenic capability. A low-grade inflammation can alter such processes leading to premature arrest of follicular growth and female reproductive failure...
2018: Frontiers in Immunology
Gábor Máté, Lori R Bernstein, Attila L Török
Approximately, 10-15% of women of reproductive age are affected by endometriosis, which often leads to infertility. Endometriosis often has an inherited component, and several causative predisposing factors are hypothesized to underlie the pathogenesis of endometriosis. One working hypothesis is the theory of retrograde menstruation. According to the theory of retrograde menstruation, components of refluxed blood, including apoptotic endometrial tissue, desquamated menstrual cells, lysed erythrocytes, and released iron, induce inflammation in the peritoneal cavity...
2018: Frontiers in Endocrinology
Samuel H Fishman, Stella Min
Utilizing data from the National Longitudinal Study of Adolescent to Adult Health (Add Health), the current study examines which maternal age at birth provides offspring with optimal opportunities for higher educational attainment. The results show that maternal age has a curvilinear relationship with offspring's educational attainment, i.e., the offspring of younger and older mothers are distinctly disadvantaged. Maternal ages 31 through 40 are associated with the highest offspring educational attainment, suggesting that women who give birth in their 30s have more favorable characteristics than younger or older mothers...
August 2018: Journal of Marriage and the Family
Hal Caswell, Charlotte de Vries, Nienke Hartemink, Gregory Roth, Silke F van Daalen
This paper presents a comprehensive theory for the demographic analysis of populations in which individuals are classified by both age and stage. The earliest demographic models were age classified. Ecologists adopted methods developed by human demographers and used life tables to quantify survivorship and fertility of cohorts and the growth rates and structures of populations. Later, motivated by studies of plants and insects, matrix population models structured by size or stage were developed. The theory of these models has been extended to cover all the aspects of age-classified demography and more...
November 2018: Ecological Monographs
Aya Goto, Yusuke Tsugawa, Keiya Fujimori
BACKGROUND: Little is known about the association between the anxiety toward the effects of radiation on reproduction caused by the Fukushima nuclear accident and the birth rate of people in Fukushima. Therefore, we examined changes and associated factors of future pregnancy intention among mothers in Fukushima Prefecture. METHODS: Using data from three postal surveys among women who registered their pregnancies in the prefecture (N = 6,751 in 2012, N = 6,871 in 2013, and N = 6,725 in 2014), we analyzed the factors associated with women's intention of future pregnancy using multivariable logistic regression models...
December 15, 2018: Journal of Epidemiology
Nan Zhao, Yumei Wang, Jinping Hua
Pentatricopeptide repeat (PPR) gene family plays an essential role in the regulation of plant growth and organelle gene expression. Some PPR genes are related to fertility restoration in plant, but there is no detailed information in Gossypium . In the present study, we identified 482 and 433 PPR homologues in Gossypium raimondii (D5 ) and G. arboreum (A2 ) genomes, respectively. Most PPR homologues showed an even distribution on the whole chromosomes. Given an evolutionary analysis to PPR genes from G. raimondii (D5 ), G...
December 2018: Journal of Genetics
Guangdou Qi, Zhifei Pan, Yuki Yamamoto, Fetra Jules Andriamanohiarisoamanana, Takaki Yamashiro, Masahiro Iwasaki, Ikko Ihara, Suchon Tangtaweewipak, Kazutaka Umetsu
The introduction of biogas plants is a promising way to recycle organic wastes with renewable energy production and reducing greenhouse gas. Application of anaerobic digestate as a fertilizer reduces the consumption of chemical fertilizers. In this study, the survival of pathogenic bacteria and plant growth promoting bacteria (PGPB) in two full-scale biogas plants operated at mesophilic condition were investigated. Feedstock and anaerobic digestate samples were collected from biogas plants and bacteria load in samples were detected using standard dilution plate method...
December 16, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
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