keyword
Keywords Interleukin 1 Receptor Accesso...

Interleukin 1 Receptor Accessory Protein

https://read.qxmd.com/read/38485911/different-gene-expression-patterns-of-il-1-family-members-in-parkinson-s-disease-results-from-bayesian-regression-model
#1
JOURNAL ARTICLE
Negin Jafariaghdam, Majid Khoshmirsafa, Alireza Zamani, Elahe Talebi-Ghane, Shadi Moradi, Faezeh Shahba, Mehrdokht Mazdeh, Mohammad Mahdi Eftekharian
Parkinson's disease, the second most prevalent neurodegenerative disorder lacking a recognized etiology, is influenced by oxidative stress and alterations in inflammatory cytokine levels. This study aimed to investigate the expression levels of Interleukin(IL)1 receptor accessory protein (IL-1RAcP), IL1β, IL1α, IL33, and IL36 genes in blood cells and serum IL-1β levels in Parkinson's disease patients compared to healthy controls (HCs).I n this case-control study, 44 Parkinson's disease patients and 44 age- and sex-matched HCs were included...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38360807/immune-endotyping-and-gene-expression-profile-of-patients-with-chronic-rhinosinusitis-with-nasal-polyps-in-the-aspirin-exacerbated-respiratory-disease-aerd-and-the-non-aerd-subgroups
#2
JOURNAL ARTICLE
Javad Nazari, Faezeh Shahba, Negin Jafariaghdam, Saleh Mohebbi, Saba Arshi, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Fatemeh Atashrazm, Saeed Amini, Maryam Roomiani, Mahnaz Jamee, Pegah Babaheidarian, Majid Khoshmirsafa, Mohammad Nabavi
BACKGROUND: Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP displays a T helper (Th)2 biased phenotype, and based on sensitivity or tolerance to aspirin or non-steroidal anti-inflammatory drugs (NSAID), is further subdivided into Aspirin-exacerbated respiratory disease (AERD) and non-AERD groups. Considering the challenge of diagnosis and treatment in patients with CRSwNP, particularly the AERD subtype, and the significance of endotyping in these patients, we examined the immune profile and endotyping based on gene expression analysis in the AERD and the non-AERD groups of patients with CRSwNP...
February 15, 2024: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38334236/emerging-functions-and-therapeutic-targets-of-il-38-in-central-nervous-system-diseases
#3
REVIEW
Yuan Gao, Luwei Cai, Yulu Wu, Min Jiang, Yidan Zhang, Wenjing Ren, Yirui Song, Lili Li, Ziguang Lei, Youzhuang Wu, Luwen Zhu, Jing Li, Dongya Li, Guohong Li, Chengliang Luo, Luyang Tao
Interleukin (IL)-38 is a newly discovered cytokine of the IL-1 family, which binds various receptors (i.e., IL-36R, IL-1 receptor accessory protein-like 1, and IL-1R1) in the central nervous system (CNS). The hallmark physiological function of IL-38 is competitive binding to IL-36R, as does the IL-36R antagonist. Emerging research has shown that IL-38 is abnormally expressed in the serum and brain tissue of patients with ischemic stroke (IS) and autism spectrum disorder (ASD), suggesting that IL-38 may play an important role in neurological diseases...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37998833/exploring-the-accessory-genome-of-multidrug-resistant-rhodococcus-equi-clone-2287
#4
JOURNAL ARTICLE
Sonsiray Alvarez Narvaez, Susan Sanchez
Decades of antimicrobial overuse to treat respiratory disease in foals have promoted the emergence and spread of zoonotic multidrug-resistant (MDR) Rhodococcus equi worldwide. Three main R. equi MDR clonal populations-2287, G2106, and G2017-have been identified so far. However, only clones 2287 and G2016 have been isolated from sick animals, with clone 2287 being the main MDR R. equi recovered. The genetic mechanisms that make this MDR clone superior to the others at infecting foals are still unknown. Here, we performed a deep genetic characterization of the accessory genomes of 207 R...
November 17, 2023: Antibiotics
https://read.qxmd.com/read/37981104/interleukin-1-receptor-accessory-protein-il-1rap-a-magic-bullet-candidate-for-immunotherapy-of-human-malignancies
#5
REVIEW
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1-RAP has essential roles in the progression, angiogenesis, and metastasis of solid tumors such as gastrointestinal tumors, lung carcinoma, glioma, breast and cervical cancers...
January 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/37868834/biomarkers-in-the-pathogenesis-diagnosis-and-treatment-of-systemic-sclerosis
#6
REVIEW
Maheswari Muruganandam, Angie Ariza-Hutchinson, Rosemina A Patel, Wilmer L Sibbitt
Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular damage, vasoinstability, and decreased perfusion with ischemia, inflammation, and exuberant fibrosis of the skin and internal organs. Biomarkers are analytic indicators of the biological and disease processes within an individual that can be accurately and reproducibly measured. The field of biomarkers in SSc is complex as recent studies have implicated at least 240 pathways and dysregulated proteins in SSc pathogenesis. Anti-nuclear antibodies (ANA) are classical biomarkers with well-described clinical classifications and are present in more than 90% of SSc patients and include anti-centromere, anti-Th/To, anti-RNA polymerase III, and anti-topoisomerase I antibodies...
2023: Journal of Inflammation Research
https://read.qxmd.com/read/37702180/interleukin-38-and-insulin-resistance
#7
JOURNAL ARTICLE
Kamil Klejbuk, Marek Strączkowski
Insulin resistance, i.e., decreased biological response to insulin, is a risk factor for many diseases, such as obesity, type 2 diabetes (T2DM), cardiovascular disease, polycystic ovary syndrome, some forms of cancer and neurodegenerative diseases. One of its main causes is chronic low-grade inflammation, mediated by the proinflammatory pathways, such as the c-Jun N-terminal kinase (JNK) pathway and the nuclear factor kappa B (NFκB) pathway. Interleukin (IL)-38 (IL-38) is a newly discovered cytokine that belongs to the IL-1 family...
September 11, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/37700160/constitutive-photomorphogenic-protein-1-ubiquitinates-interleukin-1-receptor-accessory-protein-in-human-liver-cancer
#8
JOURNAL ARTICLE
Kuan Cao, Zhiyi Liu, Jin Liu, Qinghe Hu, Wengang Shan, Bin Hu, Hengliang Shi, Bin Zhang
BACKGROUND: Constitutive photomorphogenic protein 1 (COP1) plays a pivotal role in the development and progression of several human cancers and is reported to be upregulated in liver cancer. However, the role of COP1 in human liver cancer is unclear. METHODS: We analyzed the COP1 expression in normal liver and liver cancer tissue samples using western blot and immunohistochemical analysis. We overexpressed and silenced COP1 in HepG2 and Huh7 cells and analyzed the effect on liver cancer cell proliferation...
September 12, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37634084/angptl3-negatively-regulates-il-1%C3%AE-induced-nf-%C3%AE%C2%BAb-activation-by-inhibiting-the-il1r1-associated-signaling-complex-assembly
#9
JOURNAL ARTICLE
Yu Zhang, Zi-Tong Zhang, Shi-Yuan Wan, Jing Yang, Yu-Juan Wei, Hui-Jing Chen, Wan-Zhu Zhou, Qiu-Yi Song, Shu-Xuan Niu, Ling Zheng, Kun Huang
Interleukin-1β (IL-1β)-induced signaling is one of the most important pathways in regulating inflammation and immunity. The assembly of the receptor complex, consisting of the ligand IL-1β, the IL-1 receptor (IL-1R) type 1 (IL1R1), and the IL-1R accessory protein (IL1RAP), initiates this signaling. However, how the IL1R1-associated complex is regulated remains elusive. Angiopoietin like 3 (ANGPTL3), a key inhibitor of plasma triglyceride clearance, is mainly expressed in the liver and exists in both intracellular and extracellular secreted forms...
August 26, 2023: Journal of Molecular Cell Biology
https://read.qxmd.com/read/37594094/the-diagnostic-features-of-peripheral-blood-biomarkers-in-identifying-osteoarthritis-individuals-machine-learning-strategies-and-clinical-evidence
#10
JOURNAL ARTICLE
Qiao Zhou, Jian Liu, Ling Xin, Yuedi Hu, Yajun Qi
BACKGROUND: People with osteoarthritis place a huge burden on society. Early diagnosis is essential to prevent disease progression and to select the best treatment strategy more effectively. In this study, the aim was to examine the diagnostic features and clinical value of peripheral blood biomarkers for osteoarthritis. OBJECTIVE: The goal of this project was to investigate the diagnostic features of peripheral blood and immune cell infiltration in osteoarthritis (OA)...
August 18, 2023: Current Computer-aided Drug Design
https://read.qxmd.com/read/37365840/mas-receptor-a-potential-strategy-in-the-management-of-ischemic-cardiovascular-diseases
#11
REVIEW
Ali Molaei, Emad Molaei, A Wallace Hayes, Gholamreza Karimi
MasR is a critical element in the RAS accessory pathway that protects the heart against myocardial infarction, ischemia-reperfusion injury, and pathological remodeling by counteracting the effects of AT1R. This receptor is mainly stimulated by Ang 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2. MasR activation attenuates ischemia-related myocardial damage by facilitating vasorelaxation, improving cell metabolism, reducing inflammation and oxidative stress, inhibiting thrombosis, and stabilizing atherosclerotic plaque...
July 2023: Cell Cycle
https://read.qxmd.com/read/37345579/impact-of-rehydration-following-systemic-dehydration-on-vocal-fold-gene-expression
#12
JOURNAL ARTICLE
Taylor W Bailey, Naila Cannes do Nascimento, Andrea P Santos, Abigail Cox, M Preeti Sivasankar
OBJECTIVE: Biological data on the beneficial effects of vocal fold rehydration are lacking. This study aimed to examine the effects of acute systemic dehydration on vocal fold gene expression and determine whether rehydration would reverse these changes. METHODS: Male New Zealand White rabbits (N = 24, n = 8/group) provided the animal model. Systemic dehydration was induced by 5 days of water volume restriction. Rehydration was provided by ad-lib water for 3 days following dehydration...
June 22, 2023: Laryngoscope
https://read.qxmd.com/read/37216961/il-38-blockade-induces-anti-tumor-immunity-by-abrogating-tumor-mediated-suppression-of-early-immune-activation
#13
JOURNAL ARTICLE
John P Dowling, Pavel A Nikitin, Fang Shen, Halley Shukla, James P Finn, Nirja Patel, Cezary Swider, Jamie L Bingaman-Steele, Chris Nicolescu, Eden L Sikorski, Evan J Greenawalt, Michael J Morin, Matthew K Robinson, Karen Lundgren, Benjamin C Harman
Immune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients. Targeting suppressive mechanisms acting on innate immune cells could significantly improve the incidence of clinical response by facilitating a multi-lineage response against the tumor involving both adaptive and innate immune systems. Here, we show that intra-tumoral interleukin (IL)-38 expression is a feature of a large frequency of head and neck, lung and cervical squamous cancers and correlates with reduced immune cell numbers...
2023: MAbs
https://read.qxmd.com/read/37173386/rapacaspase-9-based-suicide-gene-applied-to-the-safety-of-il-1rap-car-t-cells
#14
JOURNAL ARTICLE
Lucie Bouquet, Elodie Bôle-Richard, Walid Warda, Mathieu Neto Da Rocha, Rim Trad, Clémentine Nicod, Rafik Haderbache, Delphine Genin, Christophe Ferrand, Marina Deschamps
Even if adoptive cell transfer (ACT) has already shown great clinical efficiency in different types of disease, such as cancer, some adverse events consistently occur, and suicide genes are an interesting system to manage these events. Our team developed a new medical drug candidate, a chimeric antigen receptor (CAR) targeting interleukin-1 receptor accessory protein (IL-1RAP), which needs to be evaluated in clinical trials with a clinically applicable suicide gene system. To prevent side effects and ensure the safety of our candidate, we devised two constructs carrying an inducible suicide gene, RapaCasp9-G or RapaCasp9-A, containing a single-nucleotide polymorphism (rs1052576) affecting the efficiency of endogenous caspase 9...
May 12, 2023: Gene Therapy
https://read.qxmd.com/read/36982998/metabolite-and-proteomic-profiling-of-serum-reveals-the-differences-in-molecular-immunity-between-min-and-large-white-pig-breeds
#15
JOURNAL ARTICLE
Liyu Yang, Xin Liu, Xiaoyu Huang, Longchao Zhang, Hua Yan, Xinhua Hou, Lixian Wang, Ligang Wang
Pig diseases seriously threaten the health of pigs and the benefits of pig production. Previous research has indicated that Chinese native pigs, such as the Min (M) pig, has a better disease resistance ability than Large White (LW) pigs. However, the molecular mechanism of this resistance is still unclear. In our study, we used serum untargeted metabolomics and proteomics, interrogated to characterize differences in the molecular immunities between six resistant and six susceptible pigs raised in the same environment...
March 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36921802/drug-discovery-efforts-at-george-mason-university
#16
JOURNAL ARTICLE
Ali Andalibi, Remi Veneziano, Mikell Paige, Michael Buschmann, Amanda Haymond, Virginia Espina, Alessandra Luchini, Lance Liotta, Barney Bishop, Monique Van Hoek
With over 39,000 students, and research expenditures in excess of $200 million, George Mason University (GMU) is the largest R1 (Carnegie Classification of very high research activity) university in Virginia. Mason scientists have been involved in the discovery and development of novel diagnostics and therapeutics in areas as diverse as infectious diseases and cancer. Below are highlights of the efforts being led by Mason researchers in the drug discovery arena. To enable targeted cellular delivery, and non-biomedical applications, Veneziano and colleagues have developed a synthesis strategy that enables the design of self-assembling DNA nanoparticles (DNA origami) with prescribed shape and size in the 10 to 100 nm range...
March 13, 2023: SLAS Discovery
https://read.qxmd.com/read/36773434/car-t-cells-targeting-il-1rap-produced-in-a-closed-semiautomatic-system-are-ready-for-the-first-phase-i-clinical-investigation-in-humans
#17
JOURNAL ARTICLE
Clémentine Nicod, Mathieu Neto da Rocha, Walid Warda, Xavier Roussel, Rafik Haderbache, Evan Seffar, Rim Trad, Lucie Bouquet, Mathieu Goncalves, Léa Bosdure, Marie-Charlotte Laude, Mélanie Guiot, Christophe Ferrand, Marina Deschamps
PURPOSE OF THE STUDY: The use of chimeric antigen receptor (CAR)-T cells has demonstrated excellent results in B-lymphoid malignancies. The Advanced Therapy Medicinal Products (ATMP) status and good manufacturing practice (GMP) of CAR-T cells require particular conditions of production performed in a pharmaceutical establishment. Our team developed a new medical drug candidate for acute myeloid leukemia (AML), a CAR targeting interleukin-1 receptor accessory protein (IL-1RAP) expressed by leukemia stem cells, which will need to be evaluated in a phase I-IIa clinical trial...
February 4, 2023: Current Research in Translational Medicine
https://read.qxmd.com/read/36689483/unconventional-secretion-of-unglycosylated-orf8-is-critical-for-the-cytokine-storm-during-sars-cov-2-infection
#18
JOURNAL ARTICLE
Xiaoyuan Lin, Beibei Fu, Yan Xiong, Na Xing, Weiwei Xue, Dong Guo, Mohamed Zaky, Krishna Pavani, Dusan Kunec, Jakob Trimpert, Haibo Wu
Coronavirus disease 2019 is a respiratory infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence on the pathogenesis of SARS-CoV-2 is accumulating rapidly. In addition to structural proteins such as Spike and Envelope, the functional roles of non-structural and accessory proteins in regulating viral life cycle and host immune responses remain to be understood. Here, we show that open reading frame 8 (ORF8) acts as messenger for inter-cellular communication between alveolar epithelial cells and macrophages during SARS-CoV-2 infection...
January 23, 2023: PLoS Pathogens
https://read.qxmd.com/read/36684665/solithromycin-inhibits-il-13-induced-goblet-cell-hyperplasia-and-muc5ac-clca1-and-ano1-in-human-bronchial-epithelial-cells
#19
JOURNAL ARTICLE
Yasuhiro Kimura, Masahiro Shinoda, Masaharu Shinkai, Takeshi Kaneko
Solithromycin is a novel fluoroketolide antibiotic belonging to the class of macrolide antibiotics. Activation of the interleukin (IL)-13 receptor leads to STAT6 activation and subsequent induction of SAM pointed domain containing ETS transcription factor (SPDEF), chloride channel accessory 1 (CLCA1), and anoctamin-1 (ANO1), all of which are associated with the induction of MUC5AC. We examined the effects of solithromycin on mucin production led by IL-13 signaling. Normal human bronchial epithelial cells were grown at the air-liquid interface with IL-13 with/without solithromycin for 14 days...
2023: PeerJ
https://read.qxmd.com/read/36435922/bacterial-production-and-biophysical-characterization-of-a-hard-to-fold-scfv-against-myeloid-leukemia-cell-surface-marker-il-1rap
#20
JOURNAL ARTICLE
Aref Farokhi-Fard, Elham Bayat, Arezoo Beig Parikhani, Samira Komijani, Hooman Aghamirza Moghim Aliabadi, Soroush Sardari, Behrouz Gharib, Farzaneh Barkhordari, Kayhan Azadmanesh, Morteza Karimipoor, Haleh Bakhshandeh, Fatemeh Davami
BACKGROUND: Interleukin-1 receptor accessory protein (IL-1RAP) is one of the most promising therapeutic targets proposed for myeloid leukemia. Antibodies (Abs) specific to IL-1RAP could be valuable tools for targeted therapy of this lethal malignancy. This study is about the preparation of a difficult-to-produce single-chain variable fragment (scFv) construct against the membrane-bound isoform of human IL-1RAP using Escherichia coli (E. coli). METHODS: Different approaches were examined for refolding and characterization of the scFv...
November 26, 2022: Molecular Biology Reports
keyword
keyword
163245
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.