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Respiratory distress syndrome in preterm babies

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https://www.readbyqxmd.com/read/30216215/airway-clearance-for-the-preterm-newborn
#1
Brandi R Harbin, Ellise D Adams, Pamela V OʼNeal
PURPOSE: The purpose of this study was to explore airway clearance practices for the preterm newborn in the neonatal intensive care unit (NICU). STUDY DESIGN AND METHODS: This descriptive, retrospective medical record review analyzed airway clearance practices in a level III regional NICU from 2016 to 2017 in preterm newborns ranging from 32 weeks to 36 weeks and 6 days. There were 87 preterm newborns and 384 suctioning events reviewed during the entire length of stay...
September 13, 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/30035724/evaluation-of-developmental-outcomes-with-bayley-iii-test-in-preterm-infants-with-respiratory-distress-syndrome
#2
M Kherkheulidze, I Chkhaidze, N Kavlashvili, E Kandelaki, N Adamia, D Abelashvili, T Tabatadze
Aim of our study was assessment of developmental outcome of neonates with respiratory distress syndrome, evaluation of the impact of RDS on child's health, growth and neurodevelopment at 2 years of age. Case control study included 138 children, from those, 74 preterm (gestational age 32-36 weeks), who were divided into 2 study groups: I groups - involved 38 preterm with RDS and II group - 36 preterm patients without RDS and other neonatal problems. Control group included 42 patients born term with uncomplicated history...
June 2018: Georgian Medical News
https://www.readbyqxmd.com/read/30013381/evaluating-the-use-of-corticosteroids-in-preventing-and-treating-bronchopulmonary-dysplasia-in-preterm-neonates
#3
REVIEW
Oreoluwa Olaloko, Raihan Mohammed, Utkarsh Ojha
Approximately 15 million babies worldwide are born premature, and complications of prematurity are one of the leading causes of death in neonates. Neonatal respiratory distress syndrome (NRDS) and bronchopulmonary dysplasia (BPD) are two of the most common and serious consequences of prematurity. Synthetic corticosteroids, including dexamethasone, have been central in efforts to treat and prevent BPD. There is strong evidence to show that prenatal corticosteroids reduce infant mortality and the incidence of NRDS, leading to their widespread use in obstetric units...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29910162/corpus-callosum-and-cerebellar-vermis-size-in-very-preterm-infants-relationship-to-long-term-neurodevelopmental-outcome
#4
Po-Ming Wu, Hsin-I Shih, Wen-Hao Yu, Li-Wen Chen, Lie-Chuan Wang, Chao-Ching Huang, Yi-Fang Tu
BACKGROUND: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. METHODS: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age...
June 1, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29900526/transplacental-versus-direct-fetal-corticosteroid-treatment-for-accelerating-fetal-lung-maturation-where-there-is-a-risk-of-preterm-birth
#5
REVIEW
Debby P Utama, Caroline A Crowther
BACKGROUND: Despite major advances in medical technology, the incidence of preterm birth remains high. The use of antenatal corticosteroid administered transplacentally, by intramuscular injection to women at risk of preterm birth, has reduced the incidence of respiratory distress syndrome and increased the survival rates of preterm infants. However, this intervention also comes with its own risks and side effects. Animal studies and early studies in pregnant women at risk of preterm birth have reported the use of an alternative route of administration, by direct intramuscular injection of corticosteroid into the fetus under ultrasound guidance, in an attempt to minimise the side-effect profile...
June 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29862364/aquaporine-5-and-epithelial-sodium-channel-%C3%AE-subunit-gene-expression-in-gastric-aspirates-in-human-term-newborns
#6
Fabiola Castorena-Torres, Mario René Alcorta-García, Víctor Javier Lara-Díaz
Both transient tachypnea of the newborn and neonatal respiratory distress syndrome have been associated with changes in gene expression of aquaporine-5 (AQP5) and the β subunit of the epithelial sodium channel (β-ENaC) in the respiratory epithelium. Gastric aspirate (GA) obtained immediately after birth could represent a new source for gene expression analysis for these respiratory diseases. The aims of this study were to determine the feasibility of estimating AQP5 and β-ENaC gene expression in exfoliated respiratory epithelial cells from the GA of term neonates, and to compare the values with those found in scraped nasal epithelial cells, previously validated as a surrogate for distal lung epithelium in terms of ionic channel activity...
April 2018: Heliyon
https://www.readbyqxmd.com/read/29543861/impact-of-hypothermia-on-implementation-of-cpap-for-neonatal-respiratory-distress-syndrome-in-a-low-resource-setting
#7
Jennifer Carns, Kondwani Kawaza, M K Quinn, Yinsen Miao, Rudy Guerra, Elizabeth Molyneux, Maria Oden, Rebecca Richards-Kortum
BACKGROUND: Neonatal hypothermia is widely associated with increased risks of morbidity and mortality, but remains a pervasive global problem. No studies have examined the impact of hypothermia on outcomes for preterm infants treated with CPAP for respiratory distress syndrome (RDS). METHODS: This retrospective analysis assessed the impact of hypothermia on outcomes of 65 neonates diagnosed with RDS and treated with either nasal oxygen (N = 17) or CPAP (N = 48) in a low-resource setting...
2018: PloS One
https://www.readbyqxmd.com/read/29459604/immediate-outcome-of-preterm-neonates-with-respiratory-distress-syndrome-required-mechanical-ventilation
#8
M A Mannan, M A Hossain, J Nasim, Y Sabina, F Navila, D Subir
Since its inception, the neonatal mechanical ventilator has been considered an essential tool for managing preterm neonates with Respiratory Distress Syndrome (RDS) and is still regarded as an integral component in the neonatal respiratory care continuum. Mechanical ventilation of newborn has been practiced for several years with several advances made in the way. This clinical intervention study was done to analyze immediate outcome of preterm neonates with RDS required mechanical ventilation and conducted on preterm neonates with RDS required mechanical ventilation from July 2014 to June 2015...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29374641/successful-percutaneous-drainage-of-pneumatoceles-in-an-extremely-low-birthweight-infant
#9
Jogender Kumar, Kanya Mukhopadhyay, Anmol Bhatia
Pneumatoceles are thin-walled, air-filled cystic lesions developing within the lung parenchyma. It used to be a relatively common entity in the presurfactant era when preterm babies were ventilated at an unacceptably high positive pressure for respiratory distress syndrome. Pneumatocele formation is a very rare complication of pneumonia in neonates. We here report a case of extremely low-birthweight (ELBW) neonate who developed large bilateral pneumatoceles after staphylococcal pneumonia. Hereby, we present a case of an ELBW infant with bilateral massive pneumatoceles who underwent successful percutaneous catheter drainage to decompress these pneumatoceles...
January 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29365196/effect-of-antenatal-steroids-on-respiratory-morbidity-of-late-preterm-newborns-a-randomized-controlled-trial
#10
Vijaya Ontela, Gowri Dorairajan, Vishnu B Bhat, Palanivel Chinnakali
Objective: The objective of this article was to study the effect of antenatal dexamethasone on the respiratory morbidity of late preterm newborns. Study design: A randomized controlled trial, conducted in Obstetrics and Gynecology Department in collaboration with Neonatology department at JIPMER, India. In total, 155 women were studied in each group. Intention to treat analysis and per protocol analysis were done. Results: Overall 31 (10%) newborns were admitted to intensive care unit...
January 22, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29076668/efficacy-of-two-regimens-of-dexamethasone-for-management-of-preterm-labour-pilot-study
#11
Ahsan Rasool, Umer Farooq, Qurat-Ul-Ann Nazir, Hira Bahar Durani
BACKGROUND: Dexamethasone is widely used for prevention of respiratory distress syndrome (RDS), necrotising enterocolitis (NEC) and intra-ventricular haemorrhage (IVH) in preterm babies; decreasing the neonatal mortality rate. There is no consensus on the dose of corticosteroid administered to the mother expected to have a preterm baby. This study is conducted to compare the effectiveness of two popular regimens of dexamethasone administration in decreasing incidence of RDS, necrotizing enterocolitis, IVH and neonatal mortality rate...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28970693/acute-respiratory-distress-syndrome-in-a-neonate-due-to-possible-transfusion-related-acute-lung-injury
#12
Arti Maria, Sheetal Agarwal, Anu Sharma
Transfusion-related acute lung injury (TRALI) is a potentially life-threatening complication of blood component transfusion. It is relatively underdiagnosed entity in neonates with scant literature. We report a case of TRALI in a preterm neonate developing acute respiratory distress within 6 h of blood product transfusion in the absence of preexisting lung disease. Prompt ventilator and supportive management were instituted. The baby showed clinical and radiological improvement within 12 h; however, he succumbed to death due to acute massive pulmonary hemorrhage 36 h later...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28567102/neonatal-respiratory-distress-syndrome-chest-x-ray-or-lung-ultrasound-a-systematic-review
#13
REVIEW
Matthew Hiles, Anne-Marie Culpan, Catriona Watts, Theresa Munyombwe, Stephen Wolstenhulme
BACKGROUND AND AIM: Neonatal respiratory distress syndrome is a leading cause of morbidity in preterm new-born babies (<37 weeks gestation age). The current diagnostic reference standard includes clinical testing and chest radiography with associated exposure to ionising radiation. The aim of this review was to compare the diagnostic accuracy of lung ultrasound against the reference standard in symptomatic neonates of ≤42 weeks gestation age. METHODS: A systematic search of literature published between 1990 and 2016 identified 803 potentially relevant studies...
May 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/28542663/-periorbital-pallor-post-application-of-mydriatic-in-infants-with-hydrocephalus-associated-to-systemic-effects
#14
Jorge Luis Alvarado Socarras, Sandra Consuelo Rodríguez
Adequate pupil dilation is needed to evaluate some neonates at risk of developing illness during this stage. However, this procedure is not free of adverse effects, either local or systemic. One of these complications is the local vasoconstriction of the preterm baby’s skin following the application of mydriatic eye drops. OBJECTIVE: To describe secondary local and systemic complications of pharmacological pupil dilation in 2 newborns. Clinical case 1: Full term baby with diagnosis of low-birth weight and hydrocephalia...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28520902/early-acquisition-of-pneumocystis-jirovecii-colonization-and-potential-association-with-respiratory-distress-syndrome-in-preterm-newborn-infants
#15
Pilar Rojas, Vicente Friaza, Elisa García, Carmen de la Horra, Sergio L Vargas, Enrique J Calderón, Antonio Pavón
Background: Pneumocystis pneumonia is a well-recognized lung disease of premature and malnourished babies. Even though serologic studies have shown that children are exposed to Pneumocystis jirovecii early in life, the epidemiology of human P. jirovecii infection and the host-microorganism relationship in infancy remain poorly understood. The aim of the present study was to investigate the prevalence of P. jirovecii colonization in preterm infants and its possible association with medical complications...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28492159/iloprost-instillation-in-two-neonates-with-pulmonary-hypertension
#16
Sezin Unal, Selma Aktas, Meltem Aksu, Ibrahim M Hirfanoglu, Yildiz Atalay, Canan Turkyilmaz
Pulmonary hypertension may coexist with certain diseases in neonates. Iloprost inhalation is one of the treatments which cause selective pulmonary vasodilatation. Inhalation is not an easy way of drug administration in mechanically ventilated infants; as some exhibit desaturations during inhalation. Moreover, inhalation of drug requires cessation of mechanical ventilation, if patient is on high frequency oscillatory ventilation. We presented two patients with pulmonary hypertension; term baby with congenital diaphragmatic hernia and preterm baby with respiratory distress syndrome; who had iloprost instillation during mechanical ventilation treatment...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28465315/a-first-in-human-clinical-study-of-a-new-sp-b-and-sp-c-enriched-synthetic-surfactant-chf5633-in-preterm-babies-with-respiratory-distress-syndrome
#17
MULTICENTER STUDY
David G Sweet, Mark A Turner, Zbyněk Straňák, Richard Plavka, Paul Clarke, Ben J Stenson, Dominique Singer, Rangmar Goelz, Laura Fabbri, Guido Varoli, Annalisa Piccinno, Debora Santoro, Christian P Speer
OBJECTIVE: CHF5633 (Chiesi Farmaceutici S.p.A., Parma, Italy) is the first fully synthetic surfactant enriched by peptide analogues of two human surfactant proteins. We planned to assess safety and tolerability of CHF5633 and explore preliminary efficacy. DESIGN: Multicentre cohort study. PATIENTS: Forty infants from 27+0 to 33+6 weeks gestation with respiratory distress syndrome requiring fraction of inspired oxygen (FiO2 ) ≥0.35 were treated with a single dose of CHF5633 within 48 hours after birth...
November 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28282822/neonatal-outcomes-following-planned-preterm-delivery-in-diabetic-mothers
#18
E V Cope, N Sultana, E A Masson, B J Allen, A Oboh, L Wilkinson, C Wood, S W Lindow
OBJECTIVE: Women with diabetes may need elective preterm delivery due to pregnancy or diabetes related complications. The aim of this study was to describe the neonatal outcomes arising from elective preterm delivery in diabetic women. METHOD: Suitable patients were identified by the obstetric team at Hull Royal Infirmary Women and Children's Hospital and data was extracted from their case notes. 45 diabetic women with planned preterm delivery were identified within a set time frame, resulting in 48 babies...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28257562/planned-early-birth-versus-expectant-management-for-women-with-preterm-prelabour-rupture-of-membranes-prior-to-37-weeks-gestation-for-improving-pregnancy-outcome
#19
REVIEW
Diana M Bond, Philippa Middleton, Kate M Levett, David P van der Ham, Caroline A Crowther, Sarah L Buchanan, Jonathan Morris
BACKGROUND: Current management of preterm prelabour rupture of the membranes (PPROM) involves either initiating birth soon after PPROM or, alternatively, adopting a 'wait and see' approach (expectant management). It is unclear which strategy is most beneficial for mothers and their babies. This is an update of a Cochrane review published in 2010 (Buchanan 2010). OBJECTIVES: To assess the effect of planned early birth versus expectant management for women with preterm prelabour rupture of the membranes between 24 and 37 weeks' gestation for fetal, infant and maternal well being...
March 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28239269/risk-factors-and-prediction-models-for-retinopathy-of-prematurity
#20
Mallika Prem Senthil, Mohamad Aziz Salowi, Mohamad Adam Bujang, Adeline Kueh, Chong Min Siew, Kala Sumugam, Chan Lee Gaik, Tan Aik Kah
OBJECTIVES: To develop a simple prediction model for the pre-screening of Retinopathy of Prematurity (ROP) among preterm babies. METHODS: This was a prospective study. The test dataset (January 2007 until December 2010) was used to construct risk prediction models, and the validation dataset (January 2011 until March 2012) was used to validate the models developed from the test dataset. Two prediction models were produced using the test dataset based on logistic regression equations in which the development of ROP was used as the outcome...
September 2015: Malaysian Journal of Medical Sciences: MJMS
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