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Central pain syndrome

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https://www.readbyqxmd.com/read/30321201/the-val158met-polymorphism-of-the-catechol-o-methyltransference-gene-is-not-associated-with-long-term-treatment-outcomes-in-carpal-tunnel-syndrome-a-randomized-clinical-trial
#1
César Fernández-de-Las-Peñas, Silvia Ambite-Quesada, Hommid Fahandezh-Saddi Díaz, Paula Paras-Bravo, Domingo Palacios-Ceña, Maria L Cuadrado
DESIGN: Randomized clinical trial. OBJECTIVE: To investigate the association of the Val158Met polymorphism with pain and function outcomes in women with carpal tunnel syndrome (CTS) who received surgery or manual therapy including desensitization manoeuvres of the central nervous system. METHODS: A pre-planned secondary analysis of a randomized controlled trial investigating the efficacy of manual therapy including desensitization manoeuvres of the central nervous system vs...
2018: PloS One
https://www.readbyqxmd.com/read/30319458/depressive-syndromes-in-autoimmune-disorders-of-the-nervous-system-prevalence-etiology-and-influence
#2
REVIEW
Yanjun Liu, Xiangqi Tang
Autoimmune diseases of the nervous system (ADNS) consist of a group of severely disabling disorders characterized by abnormal immune attack against protein components of the nervous system. This type of attack behavior may occur in the central or peripheral nervous system, and in the neuromuscular junction, resulting in neuronal damage, axonal injury, demyelination or destruction of the neuromuscular junction. While the neurological deficits of patients with ADNS have received significant research attention, the manifestation of depression tends to be ignored...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30318915/hip-spine-syndrome-cross-sectional-study-of-spinal-alignment-in-patients-with-coxalgia
#3
Masayuki Miyagi, Kensuke Fukushima, Gen Inoue, Toshiyuki Nakazawa, Takayuki Imura, Wataru Saito, Naonobu Takahira, Masashi Takaso
INTRODUCTION: Patients presenting with hip diseases often have coexisting spine disorders, a condition that is termed "hip-spine syndrome." However, few reports have evaluated total spinal alignments in patients with coxalgia. In this study, we retrospectively examined the relationship between several clinical and x-ray parameters of the hip joints and spinal alignment in patients with coxalgia. METHODS: 100 patients with coxalgia (24 men, 76 women; average age, 60...
October 14, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/30312811/a-rare-and-symptomatic-cavernous-donut-shaped-aneurysm-treated-by-flow-diverter-deployment
#4
Alessandro Sgreccia, Antonio Caragliano, Giuseppina Sanfilippo, Serena Campa, Roberto Trignani, Mirko Giannoni, Maurizio De Nicola, Arturo Consoli, Georges Rodesch, Gabriele Polonara
We describe the case of a 62-year-old woman, who was admitted at our center for acute diplopia secondary to a left III cranial nerve palsy, left eyelid swelling and ptosis, and mild ipsilateral retro-orbital pain. No other motor or sensitive deficits were observed. A CT-Angiography (CTA) and a Digital Subtraction Angiography (DSA) were performed, showing a 25 mm left intra-cavernous aneurysm with a central intrasaccular thrombus, an intra-saccular "swirling" flow with a donut-shape appearance. A flow-diverter stent (FD) was deployed bridging the aneurysmal neck...
October 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30312451/pain-expansion-and-severity-reflect-central-sensitization-in-primary-care-patients-with-greater-trochanteric-pain-syndrome
#5
Raúl Ferrer-Peña, Daniel Muñoz-García, César Calvo-Lobo, Josué Fernández-Carnero
Objectives: The aims of this study were twofold: 1) to evaluate the differences in pain sensitivity of patients with greater trochanteric pain syndrome (GTPS) and 2) to examine the association between pain expansion, pain severity, and pain-related central sensitization somatosensory variables in patients with GTPS. Study Design: A cross-sectional study. Setting: Primary health care centers. Subjects: The sample consisted of 49 participants with a mean age of 48...
October 11, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/30309244/association-of-fatigue-with-tph2-genetic-polymorphisms-in-women-with-irritable-bowel-syndrome
#6
Claire J Han, Monica E Jarrett, Kevin C Cain, Sangeun Jun, Margaret M Heitkemper
Fatigue is the most common extraintestinal symptom in women with irritable bowel syndrome (IBS). Genetic polymorphisms of monoamines are associated with fatigue in many chronic diseases. In this pilot exploratory study, the primary aim was to determine whether genetic polymorphisms of tryptophan hydroxylase ( TPH1/TPH2), serotonin reuptake transporter ( SERT), or catechol-O-methyltransferase ( COMT) are associated with fatigue in women with IBS. Additionally, analysis explored whether these genetic associations with fatigue would be present when controlling for abdominal pain, psychological distress, feeling stressed, and sleepiness during the day...
October 11, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/30306527/involvement-of-p-2-x-7-receptors-and-bdnf-in-the-pathogenesis-of-central-poststroke-pain
#7
Yung-Hui Kuan, Hsi-Chien Shih, Bai-Chuang Shyu
Central pain is commonly found in patients with neurological complications that are associated with central nervous system insult, such as stroke. It can result directly from central nervous system injury. Impairments in sensory discrimination can make it challenging to differentiate central neuropathic pain from other types of pain or spasticity. Central neuropathic pain may also begin months to years after the injury, further obscuring the recognition of its association with past neurologic injury. This chapter focuses on the involvement of P2 X7 receptor and brain-derived neurotrophic factor (BDNF) in central poststroke pain (CPSP)...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30305036/sickle-cell-disease-a-case-report-of-renal-amyloidosis
#8
Ann Bugeja, Paula Blanco, Edward G Clark, Manish M Sood
BACKGROUND: The development of proteinuria and reduced glomerular filtration rate is associated with higher mortality among patients with sickle cell disease (SCD). AA amyloidosis, also associated with increased mortality, in SCD is rare. We present a case of a woman with homozygous sickle cell disease with nephrotic syndrome and antibodies to double stranded DNA without clinical features of systemic lupus erythematosus. Kidney biopsy reveals AA amyloidosis and is the first report of concomitant AA amyloidosis with antibodies to double stranded DNA in SCD...
October 10, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30301458/syringomyelia-like-syndrome-in-neuromyelitis-optica-spectrum-disorder-complicated-with-sjogren-s-syndrome-a-case-report
#9
Xiangling Li, Zhengqi Lu, Yanqiang Wang
BACKGROUND: Besides CSF-flow obstruction, syringomyelia is associated with inflammatory spinal cord lesions. However, syringomyelia-like syndrome concomitant with neuromyelitis optica spectrum disorder (NMOSD) and primary Sjogren's syndrome (pSS) is extremely rare. Here, we would like to report a case of a patient with syringomyelia-like syndrome in NMOSD complicated with Sjogren's Syndrome. CASE PRESENTATION: A 64-old male Han Chinese, presented with three episodes of acute demyelinating processes in the central nervous system within 5 years...
October 9, 2018: BMC Neurology
https://www.readbyqxmd.com/read/30298195/the-clinical-features-and-outcome-of-scan-negative-and-scan-positive-cases-in-suspected-cauda-equina-syndrome-a-retrospective-study-of-276-patients
#10
Ingrid Hoeritzauer, Savva Pronin, Alan Carson, Patrick Statham, Andreas K Demetriades, Jon Stone
BACKGROUND: The majority of patients presenting with suspected clinical cauda equina syndrome (CES) have no identifiable structural cause for their symptoms ('scan-negative' CES). Understanding these patients aids clinical differentiation and management in CES. METHODS: A retrospective electronic note review was undertaken of patients presenting with suspected CES, defined as ≥ 1 of acute bladder, bowel, sexual dysfunction or saddle numbness, to a regional neurosciences centre...
October 8, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30295542/neurosarcoidosis-as-a-rare-differential-diagnosis-for-single-or-multiple-lesions-of-the-nervous-system
#11
Christian Blume, Izabela Tuleta, Kay Nolte, Klaus W Eichhorn, Mark Jakob, Hans Clusmann, Thorsten Send
OBJECTIVE: Sarcoidosis is a multisystemic granulomatous disease of unknown cause which affects the lung or bilateral hilar lymphadenopathy in over 90% of the cases. Neurosarcoidosis (NS) is rare and accounts for approximately 5 - 15% of the cases. Involvement of all parts of the central and peripheral nervous system is possible with various clinical symptoms, e. g. seizures, hydrocephalus, optic/facial nerve palsy or hearing loss. METHODS: We screened the neuropathological data bases and the medical records of two neurosurgical university hospitals for cases of NS...
October 8, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/30273154/optically-pumped-magnetometers-for-magneto-myography-to-study-the-innervation-of-the-hand
#12
Philip J Broser, Svenja Knappe, Diljit-Singh Kajal, Nima Noury, Orang Alem, Vishal Shah, Christoph Braun
The central nervous system exerts control over the activation of muscles via a dense network of nerve fibres targeting each individual muscle. There are numerous clinical situations were a detailed assessment of the nerve-innervation pattern is required for diagnosis and treatment. Especially deep muscles are hard to examine and are as yet only accessible by uncomfortable and painful needle EMG techniques. Just recently, a new and flexible method and device became available to measure the small magnetic fields generated by the contraction of the muscles: Optically pumped magnetometers (OPM)...
September 24, 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/30270423/psychological-therapies-for-the-management-of-chronic-and-recurrent-pain-in-children-and-adolescents
#13
REVIEW
Emma Fisher, Emily Law, Joanne Dudeney, Tonya M Palermo, Gavin Stewart, Christopher Eccleston
BACKGROUND: This is an update of the original Cochrane review first published in Issue 1, 2003, and previously updated in 2009, 2012 and 2014. Chronic pain, defined as pain that recurs or persists for more than three months, is common in childhood. Chronic pain can affect nearly every aspect of daily life and is associated with disability, anxiety, and depressive symptoms. OBJECTIVES: The aim of this review was to update the published evidence on the efficacy of psychological treatments for chronic and recurrent pain in children and adolescents...
September 29, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30267847/a-new-central-post-stroke-pain-rat-model-autologous-blood-injected-thalamic-hemorrhage-involved-increased-expression-of-p2x4-receptor
#14
Hai-Feng Lu, Chun-Yang Xu, Lei Zhang, Lei Gan, Chan Chen, Man-Yun Yan, Xiao-Ning Guo, Qi Fang, Guang-Yin Xu, Yan-Bo Zhang, Jian-Qiang Ni, Hong-Ru Zhao
Stroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understand of the pathophysiological basis of CPSP, we developed and characterized a new rat model of CPSP. This model is based on a hemorrhagic stroke lesion with intra-thalamic autologous blood (ITAB) injection in the ventral posterolateral nucleus of the thalamus...
September 26, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/30266480/surgical-management-of-upper-extremity-deformities-in-patients-with-upper-motor-neuron-syndrome
#15
REVIEW
Peter Charles Rhee
Injury to the central nervous system can create upper extremity deformities and dysfunction, typically caused by a cerebrovascular accident, traumatic brain injury, anoxic brain injury, or spinal cord injury. Regardless of the etiology, disruption of inhibitory upper motor neuron (UMN) pathways can lead to a constellation of symptoms such as muscle weakness, decreased motor control, hyperexcitable tendon reflexes, muscle spasticity, and agonist-antagonist cocontraction that characterizes a condition known as UMN syndrome...
September 25, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/30251310/perioperative-anesthetic-management-of-children-with-congenital-central-hypoventilation-syndrome-and-rapid-onset-obesity-with-hypothalamic-dysfunction-hypoventilation-and-autonomic-dysregulation-undergoing-thoracoscopic-phrenic-nerve-diaphragm-pacemaker-implantation
#16
Heather A Ballard, Olga S Leavitt, Anthony C Chin, Rashmi Kabre, Debra E Weese-Mayer, John Hajduk, Narasimhan Jagannathan
BACKGROUND: Congenital Central Hypoventilation Syndrome and Rapid-Onset Obesity with Hypothalamic dysfunction, Hypoventilation, and Autonomic Dysregulation are rare neurocristopathies characterized by autonomic dysregulation including bradyarrhythmias, abnormal temperature control, and most significantly, abnormal control of breathing leading to tracheostomy and ventilator dependence as life support. Surgical advancements have made phrenic nerve-diaphragm pacemakers available, to eliminate the tether to a mechanical ventilator for 12-15 hours each day...
September 24, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/30243159/prevalence-of-pain-in-patients-with-breast-cancer-post-treatment-a-systematic-review
#17
REVIEW
Katie Wang, Caitlin Yee, Samantha Tam, Leah Drost, Stephanie Chan, Pearl Zaki, Victoria Rico, Krista Ariello, Mark Dasios, Henry Lam, Carlo DeAngelis, Edward Chow
PURPOSE: To evaluate the prevalence and severity of persistent pain after breast cancer treatment (PPBCT) in patients who received surgery, radiotherapy or a combination of treatments and to explore how different treatments and techniques impact pain. METHODS: Medline, Embase and Cochrane Central databases were searched for articles which evaluated the prevalence of PPBCT. Search results were limited to studies addressing chronic post-surgical pain (CPSP), persistent post-surgical pain (PPSP), post-mastectomy pain syndrome (PMPS) or radiotherapy (RT) related pain in breast cancer patients and published in the English language...
September 4, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30242309/association-of-leucine-rich-glioma-inactivated-protein-1-contactin-associated-protein-2-and-contactin-2-antibodies-with-clinical-features-and-patient-reported-pain-in-acquired-neuromyotonia
#18
Angela Vincent, Philippa Pettingill, Rosie Pettingill, Bethan Lang, Ron Birch, Patrick Waters, Sarosh R Irani, Camilla Buckley, Osamu Watanabe, Kimiyoshi Arimura, Matthew C Kiernan
Importance: Although acquired autoimmune neuromyotonia (NMT) is associated with voltage-gated potassium channel (VGKC)-complex antibodies, to date there has been no systematic study of autoantibodies to the specific antigens leucine-rich glioma inactivated protein 1 (LGI1), contactin-associated protein 2 (CASPR2), and contactin 2 together with the full clinical syndrome, particularly pain and autonomic and central nervous system involvement. Objectives: To study the full spectrum of clinical features and serum autoantibodies in patients with NMT, including the effects of pain on quality of life...
September 17, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/30238382/fibromyalgia-and-small-fiber-neuropathy-the-plot-thickens
#19
Manuel Martínez-Lavín
Several groups of investigators have described the presence of small fiber neuropathy in fibromyalgia patients. This writing discusses how this new finding could renovate fibromyalgia concept, diagnosis, and treatment. Predominant rheumatology thinking proposes fibromyalgia as a "centralized pain syndrome." An alternative hypothesis views fibromyalgia as a stress-related dysautonomia with neuropathic pain features. Dorsal root ganglia may be the key autonomic-nociceptive short-circuit sites. The recent recognition of small fiber neuropathy in a large subgroup of fibromyalgia patients reinforces the dysautonomia-neuropathic hypothesis and validates fibromyalgia pain...
September 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30235917/peripheral-and-central-metabolites-affecting-depression-anxiety-suicidal-ideation-and-anger-in-complex-regional-pain-syndrome-patients-using-a-magnetic-resonance-spectroscopy-a-pilot-study
#20
Ye-Ha Jung, Hyeonjin Kim, So Yeon Jeon, Jeong Min Kwon, Won Joon Lee, Joon Hwan Jang, Dasom Lee, Yoonji Lee, Do-Hyung Kang
OBJECTIVE: This study investigated peripheral and central metabolites affecting depression, anxiety, suicidal ideation, and anger in complex regional pain syndrome (CRPS) patients. METHODS: Metabolite levels were determined in the right and left thalamus and insula, in 12 CRPS patients using magnetic resonance spectroscopy (MRS). RESULTS: There were positive correlations between valine (Val)/tNAA (N-acetylaspartate+N-acetylaspartylglutamate) and the anxiety, and a negative correlation between glutamine (Gln)/NAA and the depression...
September 2018: Psychiatry Investigation
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