Georg Lorenz, Yuli Shen, Renate Ilona Hausinger, Caroline Scheid, Marie Eckermann, Sophia Hornung, Joana Cardoso, Maciej Lech, Andrea Ribeiro, Bernhard Haller, Christopher Holzmann-Littig, Dominik Steubl, Matthias C Braunisch, Roman Günthner, Andreas Poschenrieder, Britt Freitag, Mario Weber, Peter Luppa, Uwe Heemann, Christoph Schmaderer
Extended cut-off filtration by medium cut-off membranes (MCO) has been shown to be safe in maintenance hemodialysis (HD). The notion of using them for the control of chronic low-grade inflammation and positively influencing cellular immune aberrations seems tempting. We conducted an open label, multicenter, randomized, 90 day 2-phase cross over clinical trial (MCO- vs. high flux-HD). 46 patients underwent randomization of which 34 completed the study. Dialysate- or pre- and post-dialysis serum inflammatory mediators were assayed for each study visit...
September 30, 2022: Scientific Reports