Amr Hassan, Reham Mohsen, Ahmed Rezk, Gabrielle Bangay, Patrícia Rijo, Mona F M Soliman, Mohamed G A Hablas, Khalifa AbdulRazik K Swidan, Tahseen S Mohammed, Mohammad A Zoair, Abir A Khalil Mohamed, Tamer I Abdalrhman, Ahmad M Abdel-Aleem Desoky, Dalia D Mohamed, Doaa D Mohamed, Ahmed I Abd El Maksoud, Aly F Mohamed
Vitamin C was examined to ameliorate the neurotoxicity of thimerosal (THIM) in an animal model (Wistar albino rats). In our work, oxidative and antioxidative biomarkers such as SOD, LPO, and GSH were investigated at various doses of THIM with or without concurrent vitamin C administration. Furthermore, the adverse effects of THIM on hepatic tissue and cerebral cortex morphology were examined in the absence or presence of associated vitamin C administration. Also, we studied the effect of vitamin C on the metallothionein isoforms (MT-1, MT-2, and MT-3) in silico and in vivo using the RT-PCR assay...
February 27, 2024: ACS Omega