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https://www.readbyqxmd.com/read/29141232/foxp1-promotes-embryonic-neural-stem-cell-differentiation-by-repressing-jagged1-expression
#1
Luca Braccioli, Stephin J Vervoort, Youri Adolfs, Cobi J Heijnen, Onur Basak, R Jeroen Pasterkamp, Cora H Nijboer, Paul J Coffer
Mutations in FOXP1 have been linked to neurodevelopmental disorders including intellectual disability and autism; however, the underlying molecular mechanisms remain ill-defined. Here, we demonstrate with RNA and chromatin immunoprecipitation sequencing that FOXP1 directly regulates genes controlling neurogenesis. We show that FOXP1 is expressed in embryonic neural stem cells (NSCs), and modulation of FOXP1 expression affects both neuron and astrocyte differentiation. Using a murine model of cortical development, FOXP1-knockdown in utero was found to reduce NSC differentiation and migration during corticogenesis...
November 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29140859/patient-and-caregiver-assessment-of-the-benefits-from-the-clinical-use-of-amyloid-pet-imaging
#2
Rafid Mustafa, Jared R Brosch, Gil D Rabinovici, Bradford C Dickerson, Maria C Carrillo, Bradley S Glazier, Sujuan Gao, Martha Tierney, Keith N Fargo, Mary G Austrom, Susan De Santi, David G Clark, Liana G Apostolova
INTRODUCTION: Few studies to date have explored patient and caregiver views on the clinical use of amyloid positron emission tomography (PET). METHODS: A 7-item questionnaire assessing patient and caregiver views (510 total respondents) toward amyloid PET imaging was advertised broadly through alz.org/trialmatch. RESULTS: We received 510 unique responses from 48 US states, 2 Canadian provinces, the Dominican Republic, and Greece. Both patients and caregivers indicated that they would want to receive amyloid imaging if offered the opportunity...
November 14, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29139114/operation-family-caregiver-problem-solving-training-for-military-caregivers-in-a-community-setting
#3
Leisa R Easom, Ke Wang, Renee H Moore, Heqiong Wang, Laura Bauer
OBJECTIVE: This study, conducted over a 2-year period at 9 sites, describes the outcomes of an evidence-based support program, Operation Family Caregiver, to gain an understanding of how a tailored, problem-solving training could assist military caregivers, who provide care and assistance to those injured, ill, or disabled as a result of war. METHOD: A pre-post research design was employed to examine caregiver burden, depression, health complaints, satisfaction with life, children's anxiety, and problem solving among a convenience sample of caregivers of 128 military service members and veterans...
November 15, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29138536/spotlight-on-siponimod-and-its-potential-in-the-treatment-of-secondary-progressive-multiple-sclerosis-the-evidence-to-date
#4
REVIEW
Alberto Gajofatto
Siponimod (BAF312) is a synthetic molecule belonging to the sphingosine-1-phosphate (S1P) modulator family, which has putative neuroprotective properties and well-characterized immunomodulating effects mediated by sequestration of B and T cells in secondary lymphoid organs. Compared to fingolimod (ie, precursor of the S1P modulators commercially available for the treatment of relapsing-remitting [RR] multiple sclerosis [MS]), siponimod exhibits selective affinity for types 1 and 5 S1P receptor, leading to a lower risk of adverse events that are mainly induced by S1P3 receptor activation, such as bradycardia and vasoconstriction...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29137878/integration-of-medicare-and-medicaid-for-dually-eligible-beneficiaries-a-focus-group-study-examining-beneficiaries-early-experiences-in-california-s-dual-financial-alignment-demonstration
#5
Carrie L Graham, Holly C Stewart, Elaine Kurtovich, Pi-Ju Liu
BACKGROUND: In 2014 California implemented a federal dual alignment demonstration that used a capitated managed care health plans called Cal MediConnect (CMC) to integrate medical care and long term services and supports (LTSS) for beneficiaries with both Medicare and Medicaid. These beneficiaries often have complex care needs, including multiple chronic conditions and disabilities. By 2016, 120,000 eligible beneficiaries were enrolled in the program. OBJECTIVES: Focus groups with enrolled beneficiaries were conducted to gather rich data about their early experiences with quality of care, access to care, and coordination of care in CMC plans and to identify recommendations for program improvement...
July 21, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29137531/-i-honestly-would-not-have-known-what-to-do-an-exploratory-study-of-perspectives-on-client-suicide-among-vocational-rehabilitation-support-staff
#6
Emily M Lund, Jared C Schultz, Katie B Thomas, Michael R Nadorff, Christina M Sias, Dalia Chowdhury, Nicole R DeTore, Kate Galbraith
Despite the high prevalence of suicide both overall and among people with disabilities in particular, little research has explored suicide in the context of the vocational rehabilitation (VR) system or in counseling support staff in general. We analyzed the responses of 14 VR support staff who responded to an open-ended qualitative prompt regarding their experiences with suicide training and competency. Key themes included a perceived lack of and desire for more training regarding suicide, seeking and receiving suicide training outside of VR, and a perceived lack of resources for working with suicidal clients...
January 1, 2017: Omega
https://www.readbyqxmd.com/read/29137174/hdomo-smart-sensor-integration-for-an-active-and-independent-longevity-of-the-elderly
#7
Emanuele Frontoni, Rama Pollini, Paola Russo, Primo Zingaretti, Graziano Cerri
The aim of this paper is to present the main results of HDOMO, an Ambient Assisted Living (AAL) project that involved 16 Small and Medium Enterprises (SMEs) and 2 research institutes. The objective of the project was to create an autonomous and automated domestic environment, primarily for elderly people and people with physical and motor disabilities. A known and familiar environment should help users in their daily activities and it should act as a virtual caregiver by calling, if necessary, relief efforts...
November 13, 2017: Sensors
https://www.readbyqxmd.com/read/29135837/evaluation-of-the-work-loss-data-institute-s-official-disability-guidelines
#8
Kanaka Shetty, Laura Raaen, Dmitry Khodyakov, Christina Boutsicaris, Teryl K Nuckols
OBJECTIVE: The widely used Official Disability Guidelines (ODG), a utilization review guideline for occupational conditions, has not been independently evaluated recently. METHODS: We applied the appraisal of guidelines for research and evaluation (AGREE II) and modified a measurement tool to assess systematic reviews (AMSTAR) instruments to assess guideline development methods and the quality of supporting systematic reviews. Multidisciplinary experts rated the validity of clinical content for 47 topics...
November 13, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29135457/toward-an-explanatory-framework-for-yoga-therapy-informed-by-philosophical-and-ethical-perspectives
#9
Marlysa B Sullivan, Steffany Moonaz, Kristine Weber, Jessica Noggle Taylor, Laura Schmalzl
Context • Yoga Therapy is an emerging complementary and integrative health practice for which there is increasing interest from both clinical and research perspectives. Currently missing, however, is an explanatory framework for the profession that provides practitioners, clients, and the public with an understanding of how various yogic traditions and principles can be understood in modern health care contexts. Objective • This study proposes an explanatory framework for yoga therapy, informed by phenomenology, eudaimonia, virtue ethics, and first-person ethical inquiry...
November 14, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29134630/successful-community-discharge-following-postacute-rehabilitation-for-medicare-beneficiaries-analysis-of-a-patient-centered-quality-measure
#10
Michael P Cary, Janet Prvu Bettger, Jessica M Jarvis, Kenneth J Ottenbacher, James E Graham
OBJECTIVE: To determine the sociodemographic and clinical characteristics as well as health services use associated with successful community discharge. DATA SOURCE: Inpatient Rehabilitation Facility-Patient Assessment Instrument and Medicare Provider Analysis and Review files. STUDY DESIGN: We retrospectively examined 167,664 Medicare beneficiaries discharged from inpatient rehabilitation facilities (IRFs) in 2013 to determine the sociodemographic and clinical characteristics as well as health services use associated with successful community discharge...
November 13, 2017: Health Services Research
https://www.readbyqxmd.com/read/29134479/take-flight-the-evolution-of-an-orton-gillingham-based-curriculum
#11
Jeremiah J Ring, Karen J Avrit, Jeffrey L Black
Thirty years ago in this journal, Aylett Royall Cox reported on the development of Alphabetic Phonics, a revision of the existing Orton Gillingham treatment for children with dyslexia. This paper continues that discussion and reports on the evolution of that curriculum as it is represented in a comprehensive dyslexia treatment program informed by intervention research. The paper describes the curriculum and reports data from a hospital-based learning disabilities clinic that provides qualified support for treatment efficacy and the value of added comprehension instruction...
November 13, 2017: Annals of Dyslexia
https://www.readbyqxmd.com/read/29133435/coordinated-plasticity-of-synapses-and-astrocytes-underlies-practice-driven-functional-vicariation-in-peri-infarct-motor-cortex
#12
Soo Young Kim, J Edward Hsu, Lincoln C Husbands, Jeffrey A Kleim, Theresa A Jones
Motor rehabilitative training after stroke can improve motor function and promote topographical reorganization of remaining motor cortical movement representations, but this reorganization follows behavioral improvements. A more detailed understanding of the neural bases of rehabilitation efficacy is needed to inform therapeutic efforts to improve it. Using a rat model of upper extremity impairments after ischemic stroke, we examined effects of motor rehabilitative training at the ultrastructural level in peri-infarct motor cortex...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29133325/minimally-invasive-surgery-versus-open-surgery-in-the-treatment-of-lumbar-spondylolisthesis-study-protocol-of-a-multicentre-randomised-controlled-trial-misos-trial
#13
Mark P Arts, Jasper Fc Wolfs, Jos Ma Kuijlen, Godard Cw de Ruiter
INTRODUCTION: Patients with symptomatic spondylolisthesis are frequently treated with nerve root decompression, in addition to pedicle screw fixation and interbody fusion. Minimally invasive approaches are gaining attention in recent years, although there is no clear evidence supporting the proclamation of minimally invasive spine surgery (MISS) being better than open surgery. We present the design of the MISOS (Minimal Invasive Surgery versus Open Surgery) trial on the effectiveness of MISS versus open surgery in patients with degenerative or spondylolytic spondylolisthesis...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29132847/a-scoping-review-on-interventions-to-promote-physical-activity-among-adults-with-disabilities
#14
REVIEW
Oscar Castro, Kwok Ng, Elizaveta Novoradovskaya, Grégoire Bosselut, Mary Hassandra
BACKGROUND: Despite the strong evidence that physical activity (PA) is a key determinant of health, there is limited knowledge on the content and outcomes of PA promotion interventions among individuals with disabilities. OBJECTIVE: To conduct a scoping review in order to examine the published literature on PA promotion interventions among adults with disabilities. METHODS: A scoping review following the methodological framework provided by Arksey and O'Malley used electronic databases (MEDLINE, PsycINFO, and CINAHL), reference lists, and journals to locate studies...
October 31, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29131528/the-design-of-a-social-cost-benefit-analysis-of-preventive-interventions-for-toxoplasmosis-an-example-of-the-one-health%C3%A2-approach
#15
A W M Suijkerbuijk, P F van Gils, A A Bonačić Marinović, T L Feenstra, L M Kortbeek, M-J J Mangen, M Opsteegh, G A de Wit, J W B van der Giessen
Toxoplasma gondii infections cause a large disease burden in the Netherlands, with an estimated health loss of 1,900 Disability Adjusted Life Years and a cost-of-illness estimated at €44 million annually. Infections in humans occur via exposure to oocysts in the environment and after eating undercooked meat containing tissue cysts, leading to asymptomatic or mild symptoms, but potentially leading to the development of ocular toxoplasmosis. Infection in pregnant women can lead to stillbirth and disorders in newborns...
November 12, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29130870/modern-technology-to-support-carers-of-care-recipients-with-dementia-or-functional-mental-illness-promising-progress-but-a-long-road-ahead
#16
Nicola T Lautenschlager, Janine Diehl-Schmid, Samantha M Loi, Johannes Mayer, Maria Tensil, Alexander F Kurz
There is no doubt that family carers who look after a family member with dementia or with a functional mental illness fulfill an important role, not only for their loved one, but also for the health and aged care systems of the countries they live in. Due to increasing life expectancy, but also improved healthcare the number of family carers supporting older care recipients with functional mental illness or dementia is on the rise. While the carer role often can offer rewarding experiences caregivers are at increased risk of stress, depression, sleep problems, and often experience poor health outcomes with increased morbidity and mortality (Oyebode, 2003)...
December 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29130816/the-role-of-perceived-family-social-support-and-parental-solicitous-responses-in-adjustment-to-bothersome-pain-in-young-people-with-physical-disabilities
#17
Jordi Miró, Rocío de la Vega, Kevin J Gertz, Mark P Jensen, Joyce M Engel
PURPOSE: Family social support and parental solicitous responses have been hypothesised to play an important role in paediatric pain. However, research testing the hypothesised associations between these social domains and measures of adjustment to pain in youths with disabilities and chronic pain is non-existent. METHODS: About 111 youths with physical disabilities and bothersome pain were interviewed and asked to complete measures of average pain intensity, pain interference, family social support, parent solicitous responding, and catastrophising...
November 12, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29130771/return-to-work-success-despite-conflicts-an-exploration-of-decision-making-during-a-work-rehabilitation-program
#18
Marie-Michelle Gouin, Marie-France Coutu, Marie-José Durand
PURPOSE: Collective decision-making by stakeholders appears important to return-to-work success, yet few studies have explored the processes involved. This study aims to explore the influence of decision-making on return-to-work for workers with musculoskeletal or common mental disorders. METHOD: This study is a secondary analysis using data from three earlier multiple-case studies that documented decision-making during similar and comparable work rehabilitation programs...
November 12, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29130767/using-the-international-classification-of-functioning-disability-and-health-to-identify-outcome-domains-for-a-core-outcome-set-for-aphasia-a-comparison-of-stakeholder-perspectives
#19
Sarah J Wallace, Linda Worrall, Tanya Rose, Guylaine Le Dorze
PURPOSE: This study synthesised the findings of three separate consensus processes exploring the perspectives of key stakeholder groups about important aphasia treatment outcomes. This process was conducted to generate recommendations for outcome domains to be included in a core outcome set for aphasia treatment trials. MATERIALS AND METHODS: International Classification of Functioning, Disability, and Health codes were examined to identify where the groups of: (1) people with aphasia, (2) family members, (3) aphasia researchers, and (4) aphasia clinicians/managers, demonstrated congruence in their perspectives regarding important treatment outcomes...
November 12, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29130122/arhgef9-mutations-in-epileptic-encephalopathy-intellectual-disability-toward-understanding-the-mechanism-underlying-phenotypic-variation
#20
Jing-Yang Wang, Peng Zhou, Jie Wang, Bin Tang, Tao Su, Xiao-Rong Liu, Bing-Mei Li, Heng Meng, Yi-Wu Shi, Yong-Hong Yi, Na He, Wei-Ping Liao
ARHGEF9 resides on Xq11.1 and encodes collybistin, which is crucial in gephyrin clustering and GABAA receptor localization. ARHGEF9 mutations have been identified in patients with heterogeneous phenotypes, including epilepsy of variable severity and intellectual disability. However, the mechanism underlying phenotype variation is unknown. Using next-generation sequencing, we identified a novel mutation, c.868C > T/p.R290C, which co-segregated with epileptic encephalopathy, and validated its association with epileptic encephalopathy...
November 13, 2017: Neurogenetics
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