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Neurotrophic factors

Lirong Li, Shaohua Ren, Xudong Hao, Zigang Zhen, Hongming Ji
Our aim was to explore the efficacy of minimally invasive intervention in patients with acute cerebral infarction (ACI). Seventy patients with ACI were randomized into either an experimental group or a control group. In addition to the regular treatment, patients in the control group also received intravenous thrombolysis with urokinase, while patients in the other group underwent percutaneous transluminal cerebral angioplasty and stenting. Metrics included recanalization rate, serum cytokines, fibrinolytic markers and 36-Item Short Form Health Survey score were compared between the two groups...
December 4, 2018: Journal of Cardiovascular Pharmacology
Christiano Spindler, Ethiane Segabinazi, André Luís Ferreira de Meireles, Francele Valente Piazza, Filipe Mega, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Viviane Rostirola Elsner, Simone Marcuzzo
It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained...
March 2019: Neural Regeneration Research
Hao Huang, Peipei Yan, Taoping Sun, Xiaoxing Mo, Jiawei Yin, Peiyun Li, Yalun Zhu, Shuang Rong, Wei Yang, Xiaoyi Chen, Liegang Liu
Alzheimer's disease (AD) is a progressive neurodegenerative disease, which is characterized by extracellular senile plaque deposits, intracellular neurofibrillary tangles, and neuronal apoptosis. Amyloid- β (A β ) plays a critical role in AD that may cause oxidative stress and downregulation of CREB/BDNF signaling. Anti-A β effect has been discussed as a potential therapeutic strategy for AD. This study aimed to identify the amelioration of procyanidins extracted from lotus seedpod (LSPC) on A β -induced damage with associated pathways for AD treatment...
2018: Oxidative Medicine and Cellular Longevity
Lu Zhao, William Matloff, Kaida Ning, Hosung Kim, Ivo D Dinov, Arthur W Toga
Brain structural morphology differs with age. This study examined age-differences in surface-based morphometric measures of cortical thickness, volume, and surface area in a well-defined sample of 8137 generally healthy UK Biobank participants aged 45-79 years. We illustrate that the complexity of age-related brain morphological differences may be related to the laminar organization and regional evolutionary history of the cortex, and age of about 60 is a break point for increasing negative associations between age and brain morphology in Alzheimer's disease (AD)-prone areas...
December 7, 2018: Cerebral Cortex
Laura Emilia Toader, Gabriela Camelia Roşu, Bogdan Cătălin, Ionica Pirici, Ion Cristian Gîlceavă, Valeria Carmen Albu, Anca Maria Istrate-Ofiţeru, Dafin Fior Mureşanu, Daniel Pirici
Multiple sclerosis (MS) is a complex chronic neurodegenerative disease that involves an abnormal autoimmune response directed against the brain, nerves and spinal cord; it is considered the most frequent cause of neurological disability, because MS-associated inflammatory lesions can affect a wide range of systems to a varying degree and may cause a plethora of neurological comorbidities and symptoms. The symptoms are quite variable from patient to patient and depend on the spatial distribution of the central nervous system (CNS) lesions, but usually involve sensory disturbances, cognitive deficits, unilateral vision loss, bladder dysfunction, ataxia, fatigue, double vision, weakness of the limbs and intestinal disorders...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Ashley Novais, Alberto Silva, Ana Catarina Ferreira, Ana Mendanha Falcão, Nuno Sousa, Joana Almeida Palha, Fernanda Marques, João Carlos Sousa
Neudesin (Neuron-derived neurotrophic factor, NENF), a membrane-associated progesterone receptor family (MAPR) member, is a neuron secreted protein with neurotrophic properties during embryonic stages. However, its role in the adult brain is still poorly addressed. In this study we have used neudesin-null (Nenf-/- ) mice and performed a characterization of the proliferation state of the adult neurogenic niches, the adult subventricular zone (SVZ) and the hippocampus subgranular zone (SGZ). Nenf-/- males did not presented any deficits in proliferation in the SVZ neither in vivo nor in vitro ...
2018: Frontiers in Cellular Neuroscience
Ciro De Luca, Anna Maria Colangelo, Lilia Alberghina, Michele Papa
Coagulation and the immune system interact in several physiological and pathological conditions, including tissue repair, host defense, and homeostatic maintenance. This network plays a key role in diseases of the central nervous system (CNS) by involving several cells (CNS resident cells, platelets, endothelium, and leukocytes) and molecular pathways (protease activity, complement factors, platelet granule content). Endothelial damage prompts platelet activation and the coagulation cascade as the first physiological step to support the rescue of damaged tissues, a flawed rescuing system ultimately producing neuroinflammation...
2018: Frontiers in Cellular Neuroscience
Alejandra Arias-Cavieres, Jamileth More, José Miguel Vicente, Tatiana Adasme, Jorge Hidalgo, José Luis Valdés, Alexis Humeres, Ismael Valdés-Undurraga, Gina Sánchez, Cecilia Hidalgo, Genaro Barrientos
Triclosan, a widely used industrial and household agent, is present as an antiseptic ingredient in numerous products of everyday use, such as toothpaste, cosmetics, kitchenware, and toys. Previous studies have shown that human brain and animal tissues contain triclosan, which has been found also as a contaminant of water and soil. Triclosan disrupts heart and skeletal muscle Ca2+ signaling, damages liver function, alters gut microbiota, causes colonic inflammation, and promotes apoptosis in cultured neocortical neurons and neural stem cells...
2018: Frontiers in Molecular Neuroscience
Luis Quintino, Martino Avallone, Emil Brännstrom, Patrick Kavanagh, Marcus Lockowandt, Patricia Garcia Jareño, Ludivine S Breger, Cecilia Lundberg
Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson's disease. Despite an excellent profile in experimental settings, clinical trials testing GDNF have failed. One of the theories to explain these negative outcomes is that the clinical trials were done in late-stage patients that have advanced nigrostriatal degeneration and may therefore not respond to a neurotrophic factor therapy. Based on this idea, we tested if the stage of nigrostriatal degeneration is important for GDNF-based therapies...
December 7, 2018: Gene Therapy
Omer Linkovski, Michael G Wheaton, Jordana Zwerling, Zagaa Odgerel, Peter van Roessel, Maria Filippou-Frye, Anthony Lombardi, Brianna Wright, Shari A Steinman, Helen Blair Simpson, Francis Lee, Carolyn I Rodriguez
No abstract text is available yet for this article.
December 6, 2018: Journal of Clinical Psychopharmacology
Merrill R Landers, James W Navalta, Andrew S Murtishaw, Jefferson W Kinney, Sarah Pirio Richardson
BACKGROUND AND PURPOSE: The feasibility, safety, and efficacy of a high-intensity multimodal exercise program (aerobic, strengthening, and balance training) have not been well vetted in persons with Parkinson disease (PD). Thus, the primary aim was to determine whether a high-intensity multimodal exercise boot camp (HIBC) was both feasible and safe in persons with PD. The secondary aim was to determine whether the program would produce greater benefit than a usual care, low-intensity exercise program (UC)...
January 2019: Journal of Neurologic Physical Therapy: JNPT
Andrea Cerquone Perpetuini, Justine Mathoux, Breandán N Kennedy
No abstract text is available yet for this article.
January 2019: Neural Regeneration Research
Monika Barczewska, Mariusz Grudniak, Stanisław Maksymowicz, Tomasz Siwek, Tomasz Ołdak, Katarzyna Jezierska-Woźniak, Dominika Gładysz, Wojciech Maksymowicz
Animal experiments have confirmed that mesenchymal stem cells can inhibit motor neuron apoptosis and inflammatory factor expression and increase neurotrophic factor expression. Therefore, mesenchymal stem cells have been shown to exhibit prospects in the treatment of amyotrophic lateral sclerosis. However, the safety of their clinical application needs to be validated. To investigate the safety of intrathecal injection of Wharton's jelly-derived mesenchymal stem cells in amyotrophic lateral sclerosis therapy, 43 patients (16 females and 27 males, mean age of 57...
February 2019: Neural Regeneration Research
Jian Liu, Yu-Hong Wang, Wei Li, Lin Liu, Hui Yang, Pan Meng, Yuan-Shan Han
Previous studies have shown that models of depression exhibit structural and functional changes to the neurovascular unit. Thus, we hypothesized that diabetes-related depression might be associated with damage to the hippocampal neurovascular unit. To test this hypothesis, neurons, astrocytes and endothelial cells were isolated from the brain tissues of rat embryos and newborn rats. Hippocampal neurovascular unit co-cultures were produced using the Transwell chamber co-culture system. A model of diabetes-related depression was generated by adding 150 mM glucose and 200 µM corticosterone to the culture system and compared with the neuron + astrocyte and astrocyte + endothelial cell co-culture systems...
February 2019: Neural Regeneration Research
Yana O Mukhamedshina, Olga A Gracheva, Dina M Mukhutdinova, Yurii A Chelyshev, Albert A Rizvanov
Cell-based technologies are used as a therapeutic strategy in spinal cord injury (SCI). Mesenchymal stem cells (MSCs), which secrete various neurotrophic factors and cytokines, have immunomodulatory, anti-apoptotic and anti-inflammatory effects, modulate reactivity/phenotype of astrocytes and the microglia, thereby promoting neuroregeneration seem to be the most promising. The therapeutic effect of MSCs is due to a paracrine mechanism of their action, therefore the survival of MSCs and their secretory phenotype is of particular importance...
February 2019: Neural Regeneration Research
Yftach Gepner, J R Hoffman, M W Hoffman, H Zelicha, H Cohen, I Ostfeld
INTRODUCTION: Intense military operations during deployment or training are associated with elevations in inflammatory cytokine markers. However, the influence of an inflammatory response on military-specific skills is unclear. This study examined the association between brain-derived neurotrophic factor (BDNF), glial fibrillar acidic protein, markers of inflammation, marksmanship and cognitive function following a week of intense military field training. METHODS: Twenty male soldiers (20...
December 7, 2018: Journal of the Royal Army Medical Corps
Jiucui Tong, Zhiming Zhou, Weiwei Qi, Siyan Jiang, Bin Yang, Zhengling Zhong, Yuanwei Jia, Xuyi Li, Lei Xiong, Liuwang Nie
Helicid (4-formylphenyl-β-D-allopyranoside) is a bioactive constituent of Helicid nilgirica Bedd that has been used in Chinese traditional herbal medicine to treat headache, insomnia, and depression. However, the underlying mechanisms of these effects are unclear. We have now investigated the effect of helicid on depression-related behaviors in rats exposed to chronic unpredictable mild stress (CUMS) and have also explored possible underlying mechanisms that involve neurotrophin expression. After 6 weeks isolation, body weight and sucrose preference were significantly reduced in rats with CUMS-induced depression compared with controls...
December 6, 2018: International Immunopharmacology
Takashi Suto, Daiki Kato, Hideaki Obata, Shigeru Saito
A rat model of neuropathic pain at 6 weeks after spinal nerve ligation (SNL6w) exhibits both mechanical hypersensitivity and impaired noxious stimuli-induced analgesia (NSIA). Repeated treatment with antidepressants can produce anti-hypersensitivity and restore NSIA. To examine the involvement of a brain-derived neurotrophic factor-mediated mechanism, a tropomyosin receptor kinase B (TrkB) agonist, 7,8-dihydroxyflavone (DHF), was administered to SNL6w rats (5 mg• kg-1 • day-1 , 5 days). Mechanical hypersensitivity was evaluated using the von Frey filament test and paw pressure test...
December 7, 2018: Journal of Pain: Official Journal of the American Pain Society
Hanjie Yu, Dan Lv, Mengxin Shen, Yanhua Zhang, Dongsheng Zhou, Zhongming Chen, Chuang Wang
Reserpine treatment in rodents has been shown to induce depression-like behaviors that mimic monoamine dysfunction implicated in the development of depression. Herein, we aimed to demonstrate the antidepressant-like activities of scopolamine, the muscarinic receptor antagonist, in a reserpine-induced mouse model. Mice were injected with 1.5 mg/kg (i.p.) of reserpine for 10 days, and the depression-like state was confirmed via the open field test (OFT) and forced swimming test (FST). Then, the mice were treated with scopolamine (25 µg/kg, i...
December 3, 2018: Psychiatry Research
Zhongxia Shen, Jianying Zhu, Yonggui Yuan, Lie Ren, Mincai Qian, Min Lin, Min Cai, Zhen Zhang, Xinhua Shen
Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), are involved in neuroplasticity in the nervous system. To explore the characteristics of BDNF and GDNF and their roles in predicting treatment remission in a Chinese Han population with generalized anxiety disorder (GAD), 85 GAD patients were treated with escitalopram or venlafaxine randomly for 8 weeks. The serum BDNF/GDNF levels were detected, while Hamilton Anxiety Rating Scale (HAMA) scores were measured at baseline and after 8 weeks of treatment...
August 30, 2018: Psychiatry Research
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