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Neurotrophic factors

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https://www.readbyqxmd.com/read/30326283/exercise-induced-brain-derived-neurotrophic-factor-expression-therapeutic-implications-for-alzheimer-s-dementia
#1
REVIEW
Rosy Wang, R M Damian Holsinger
Emerging evidence indicates that moderate intensity aerobic exercise is positively correlated with cognitive function and memory. However, the exact mechanisms underlying such improvements remain unclear. Recent research in animal models allows proposition of a pathway in which brain-derived neurotrophic factor (BDNF) is a key mediator. This perspective draws upon evidence from animal and human studies to highlight such a mechanism whereby exercise drives synthesis and accumulation of neuroactive metabolites such as myokines and ketone bodies in the periphery and in the hippocampus to enhance BDNF expression...
October 13, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/30326207/pre-ischemic-enriched-environment-increases-retinal-resilience-to-acute-ischemic-damage-in-adult-rats
#2
María F González Fleitas, Marcos L Aranda, Hernán H Dieguez, Julian D Devouassoux, Mónica S Chianelli, Damian Dorfman, Ruth E Rosenstein
Retinal ischemia is a condition associated with several degenerative diseases leading to visual impairment and blindness worldwide. Currently, there is no highly effective therapy for ischemic retinopathies. This study was designed to determine possible benefits of pre-exposure to enriched environment against retinal damage induced by acute ischemia. For this purpose, adult male Wistar rats were randomly assigned to a pre-ischemic standard environment or a pre-ischemic enriched environment for 3 weeks, followed by unilateral ischemia induced by increasing intraocular pressure above 120 mm Hg for 40 min and reperfusion for 1 or 2 weeks in standard environment...
October 13, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/30324331/paradoxical-sleep-deprivation-aggravates-and-prolongs-incision-induced-pain-hypersensitivity-via-bdnf-signaling-mediated-descending-facilitation-in-rats
#3
Jianjun Xue, Huili Li, Ziqing Xu, Danxu Ma, Ruijuan Guo, Kehu Yang, Yun Wang
The mechanisms underlying the pronociceptive effect of paradoxical sleep deprivation (PSD) are not fully established. The modulation of BDNF signaling-mediated descending facilitation from the rostral ventromedial medulla (RVM) of brain stem has been demonstrated in persistent pain models of inflammatory pain, but not in incisional pain model. Recent study has shown that PSD increases the expression of brain-derived neurotrophic factor (BDNF) in the brainstem structure. Therefore, in the current study, we asked whether the BDNF signaling-mediated descending facilitation was involved in the PSD-induced pronociceptive effect on incisional pain and delay the recovery period of postoperative pain in rats...
October 15, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/30324128/destabilizing-domains-enable-long-term-and-inert-regulation-of-gdnf-expression-in-the-brain
#4
Luis Quintino, Angrit Namislo, Marcus Davidsson, Ludivine S Breger, Patrick Kavanagh, Martino Avallone, Erika Elgstrand-Wettergren, Christina Isaksson, Cecilia Lundberg
Regulation of therapeutic transgene expression can increase the safety of gene therapy interventions, especially when targeting critical organs such as the brain. Although several gene expression systems have been described, none of the current systems has the required safety profile for clinical applications. Our group has previously adapted a system for novel gene regulation based on the destabilizing domain degron technology to successfully regulate glial cell-line derived neurotrophic factor in the brain (GDNF-F-DD)...
December 14, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/30323770/high-intensity-interval-training-is-associated-with-alterations-in-blood-biomarkers-related-to-brain-injury
#5
Alex P Di Battista, Katherine A Moes, Maria Y Shiu, Michael G Hutchison, Nathan Churchill, Scott G Thomas, Shawn G Rhind
Purpose: Blood biomarkers are a useful tool to study concussion. However, their interpretation is complicated by a number of potential biological confounds, including exercise. This is particularly relevant in military and athletic settings where injury commonly occurs during physical exertion. The impact of high-intensity interval training (HIIT) on putative brain injury biomarkers remains under-examined. The purpose of this study was to observe the effects of HIIT on a panel of blood biomarkers associated with brain injury...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30323763/modified-xiaoyaosan-mxys-exerts-anti-depressive-effects-by-rectifying-the-brain-blood-oxygen-level-dependent-fmri-signals-and-improving-hippocampal-neurogenesis-in-mice
#6
Lei Gao, Peng Huang, Zhaoyang Dong, Tingting Gao, Shaohui Huang, Chuying Zhou, Yuling Lai, Guanghui Deng, Bin Liu, Ge Wen, Zhiping Lv
As the traditional Chinese herbal formula, Xiaoyaosan and its modified formula have been described in many previous studies with definite anti-depressive effects, but its underlying mechanism remains mystery. Previous work in our lab has demonstrated that depression induced by chronic stress could generate brain blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals disorder, accompanied by the impairment of hippocampal neuronal plasticity, decrease of brain-derived neurotrophic factor, and reduction of the number and complexity of adult neurons in the dentate gyrus...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30323233/modulation-of-ampa-receptor-surface-diffusion-restores-hippocampal-plasticity-and-memory-in-huntington-s-disease-models
#7
Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthieu Sainlos, Dolors Grillo-Bosch, Sophie Daburon, Françoise Coussen, Yoon Cho, Denis J David, Frederic Saudou, Yann Humeau, Daniel Choquet
Impaired hippocampal synaptic plasticity contributes to cognitive impairment in Huntington's disease (HD). However, the molecular basis of such synaptic plasticity defects is not fully understood. Combining live-cell nanoparticle tracking and super-resolution imaging, we show that AMPAR surface diffusion, a key player in synaptic plasticity, is disturbed in various rodent models of HD. We demonstrate that defects in the brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signaling pathway contribute to the deregulated AMPAR trafficking by reducing the interaction between transmembrane AMPA receptor regulatory proteins (TARPs) and the PDZ-domain scaffold protein PSD95...
October 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/30323153/-huangqin-flavonoid-extraction-for-spinal-cord-injury-in-a-rat-model
#8
Qian Zhang, Li-Xin Zhang, Jing An, Liang Yan, Cui-Cui Liu, Jing-Jing Zhao, Hao Yang
Flavonoids from Huangqin (dried roots of Scutellaria baicalensis Georgi) have anti-inflammatory effects, and are considered useful for treatment of spinal cord injury. To verify this hypothesis, the T9-10 spinal cord segments of rats were damaged using Allen's method to establish a rat spinal cord injury model. Before model establishment, Huangqin flavonoid extraction (12.5 g/kg) was administered intragastrically for 1 week until 28 days after model establishment. Methylprednisolone (30 mg/kg) was injected into the tail vein at 30 minutes after model establishment as a positive control...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323150/exogenous-brain-derived-neurotrophic-factor-attenuates-cognitive-impairment-induced-by-okadaic-acid-in-a-rat-model-of-alzheimer-s-disease
#9
Ai-Hua Xu, Yang Yang, Yong-Xin Sun, Chao-Dong Zhang
Decreased expression of brain-derived neurotrophic factor (BDNF) plays an important role in the pathogenesis of Alzheimer's disease, and a typical pathological change in Alzheimer's disease is neurofibrillary tangles caused by hyperphosphorylation of tau. An in vivo model of Alzheimer's disease was developed by injecting okadaic acid (2 μL) and exogenous BDNF (2 μL) into the hippocampi of adult male Wister rats. Spatial learning and memory abilities were assessed using the Morris water maze. The expression levels of protein phosphatase 2A (PP2A), PP2Ac-Yp307, p-tau (Thr231), and p-tau (Ser396/404) were detected by western blot assay...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30322169/bdnf-brain-and-regeneration-insights-from-zebrafish
#10
REVIEW
Carla Lucini, Livia D'Angelo, Pietro Cacialli, Antonio Palladino, Paolo de Girolamo
Zebrafish ( Danio rerio ) is a teleost fish widely accepted as a model organism for neuroscientific studies. The adults show common basic vertebrate brain structures, together with similar key neuroanatomical and neurochemical pathways of relevance to human diseases. However, the brain of adult zebrafish possesses, differently from mammals, intense neurogenic activity, which can be correlated with high regenerative properties. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, has multiple roles in the brain, due also to the existence of several biologically active isoforms, that interact with different types of receptors...
October 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30322026/relationship-between-serum-bdnf-levels-and-depressive-mood-in-subacute-stroke-patients-a-preliminary-study
#11
Won Hyuk Chang, Min A Shin, Ahee Lee, Heegoo Kim, Yun-Hee Kim
The aim of this preliminary study was to investigate the potential of serum brain-derived neurotrophic factor (BDNF) as a biomarker in poststroke depressive mood in subacute stroke patients. Thirty-eight subacute stroke patients were recruited in this study. All participants underwent the standard rehabilitation program that included 2 h of physical therapy daily and 1 h of occupational therapy five days a week. The rehabilitation period lasted two weeks during the subacute stroke phase. We measured the serum BDNF, proBDNF, and matrix metalloproteinase-9 before and one and two weeks after the standard rehabilitation program...
October 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30321576/the-effect-of-the-anti-diabetic-drug-metformin-on-behavioral-manifestations-associated-with-ovariectomy-in-mice
#12
Iman Fatemi, Fatemeh Delrobaee, Maryam Bahmani, Ali Shamsizadeh, Mohammad Allahtavakoli
The aim of this study was to evaluate the anti-diabetic drug metformin (Met) effects on the anxiety and cognitive impairment in ovariectomized mice. Thirty-two female adult mice were distributed into four groups: control, sham ovariectomy, ovariectomy + Met 7 mg/kg and ovariectomy + Met 15 mg/kg. The vaginal cytology was used to confirm the ovariectomy surgery. Anxiety was monitored using elevated plus maze test and cognitive function was assessed by novel object recognition task. Animal's brains were analyzed for the brain-derived neurotrophic factor (BDNF)...
October 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/30321547/a-novel-approach-via-surface-modification-of-degradable-polymers-with-adhesive-dopa-igf-1-for-neural-tissue-engineering
#13
Yi Zhang, Zongliang Wang, Yu Wang, Linlong Li, Zhenxu Wu, Yoshihiro Ito, Xiaoyu Yang, Peibiao Zhang
The highly damaging state of spinal cord injuries has provided much inspiration for the design of surface modification of the implants that can promote nerve regeneration and functional reconstruction. DOPA-IGF-1, a new recombinant protein designed in our previous study exhibited strong binding affinity to titanium and significantly enhanced the growth of NIH3T3 cells on the surface of titanium with the same biological activity as IGF-1. In this paper, surface modification of PLGA films with recombinant DOPA-IGF-1 was performed to promote the paracrine activity of human umbilical cord mesenchymal stem cells (hUCMSCs) by secreting neurotrophic factors...
October 12, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30320260/molecular-dynamics-simulations-of-the-interactions-between-glial-cell-line-derived-neurotrophic-factor-family-receptor-gfr%C3%AE-1-and-small-molecule-ligands
#14
Larisa Ivanova, Jaana Tammiku-Taul, Alfonso T García-Sosa, Yulia Sidorova, Mart Saarma, Mati Karelson
The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) support the survival and functioning of various neuronal populations. Thus, they could be attractive therapeutic agents against a multitude of neurodegenerative diseases caused by progressive death of GFLs responsive neurons. Small-molecule ligands BT13 and BT18 show an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function. Thus, their potential binding sites and interactions were explored in the GDNF-GFRα1-RetA complex using molecular docking calculations as well as molecular dynamics (MD) simulations...
September 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/30319398/increase-in-blood-levels-of-growth-factors-involved-in-the-neuroplasticity-process-by-using-an-extremely-low-frequency-electromagnetic-field-in-post-stroke-patients
#15
Natalia Cichoń, Michał Bijak, Piotr Czarny, Elżbieta Miller, Ewelina Synowiec, Tomasz Sliwinski, Joanna Saluk-Bijak
Background: Neuroplasticity ensures the improvement of functional status in patients after stroke. The aim of this study was to evaluate the effect of extremely low-frequency electromagnetic field therapy (ELF-EMF) on brain plasticity in the rehabilitation of patients after stroke. Methods: Forty-eight patients were divided into two groups underwent the same rehabilitation program, but in the study group, the patients additionally were exposed to a standard series of 10 ELF-EMF treatments. To determine the level of neuroplasticity, we measured the plasma level of the brain-derived neurotrophic factor (BDNF), the vascular-endothelial growth factor, as well as BDNF mRNA expression...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/30319069/both-gfr%C3%AE-1a-and-1b-are-involved-in-the-self-renewal-and-maintenance-of-spermatogonial-stem-cells-in-medaka
#16
Yang Zhao, Zhuo Yang, Yuan Wang, Yubing Luo, Fan Da, Wenjing Tao, Linyan Zhou, Deshou Wang, Jing Wei
Glial cell-derived neurotrophic factor family receptor alpha-1 (GFRα1) plays a crucial role in the self-renewal and maintenance of spermatogonial stem cells (SSCs) from mammals. However, to date, our knowledge about its role in fish SSCs is limited. In the present study, the medaka (Oryzias latipes) gfrα1 duplicate genes, Olgfrα1a and Olgfrα1b, were cloned and characterized. Furthermore, their expression profile and biological activity were investigated. OlGfrα1a and OlGfrα1b contain 524 and 466 amino acid residues, respectively...
October 15, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/30317637/brain-derived-neurotrophic-factor-alleviates-the-oxidative-stress-induced-by-oxygen-and-glucose-deprivation-in-an-ex-vivo-brain-slice-model
#17
Paloma González-Rodríguez, Irene F Ugidos, Diego Pérez-Rodríguez, Berta Anuncibay-Soto, María Santos-Galdiano, Enrique Font-Belmonte, José Manuel Gonzalo-Orden, Arsenio Fernández-López
Brain-derived neurotrophic factor (BDNF) is considered as a putative therapeutic agent against stroke. Since BDNF role on oxidative stress is uncertain, we have studied this role in a rat brain slice ischemia model, which allows BDNF reaching the neural parenchyma. Hippocampal and cerebral cortex slices were subjected to oxygen and glucose deprivation (OGD) and then returned to normoxic conditions (reperfusion-like, RL). OGD/RL increased a number of parameters mirroring oxidative stress in the hippocampus that were reduced by the BDNF presence...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30317434/medial-forebrain-bundle-deep-brain-stimulation-reverses-anhedonic-like-behavior-in-a-chronic-model-of-depression-importance-of-bdnf-and-inflammatory-cytokines
#18
Manoj P Dandekar, Ashwini Saxena, Giselli Scaini, Joo Hyun Shin, Agata Migut, Vijayasree Vayalanellore Giridharan, Yuzhi Zhou, Tatiana Barichello, Jair C Soares, Joao Quevedo, Albert J Fenoy
Deep brain stimulation (DBS) of the medial forebrain bundle (MFB) displays a promising antidepressant effects in patients with treatment-refractory depression; however, a clear consensus on underlying mechanisms is still enigmatic. Herein, we investigated the effects of MFB-DBS on anhedonic-like behavior using the Froot Loops® consumption in a chronic unpredictable mild stress (CUS) model of depression, biochemical estimation of peripheral and central inflammatory cytokines, stress hormone, and brain-derived neurotrophic factor (BDNF)...
October 13, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30315387/pgc-1%C3%AE-mediated-mitochondrial-biogenesis-is-involved-in-cannabinoid-receptor-2-agonist-am1241-induced-microglial-phenotype-amelioration
#19
Lei Ma, Wen Niu, Jianrui Lv, Ji Jia, Miaozhang Zhu, Shuai Yang
Cannabinoid type 2 receptor (CB2R) agonist AM1241 induces anti-inflammation by ameliorating microglial phenotypes, the mechanism, however, is still unknown. Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) is a transcription protein which can regulate mitochondrial biogenesis, and the aim of this study is to investigate whether PGC-1α is involved in AM1241-induced anti-inflammation in N9 microglial cells. We used 10 ng/ml lipopolysaccharide (LPS) plus 10 U/ml interferon γ (IFNγ) to activate microglia into classic activated phenotype (M1 phenotype), and found that co-administration of 10 µM AM1241 increased the expressions of mitochondria biogenesis-associated proteins, including nuclear respiratory factor 1 (NRF-1), mitochondrial transcription factor A (TFAM) and COX IV, and up-regulated the biomarker levels of microglial M2 phenotype, including arginase 1 (Arg-1) and brain-derived neurotrophic factor (BDNF), and down-regulated biomarker levels of M1 phenotype, including inducible nitric oxide synthase (iNOS) and tumor necrosis factor α (TNF-α), compared to the cells treated with LPS plus IFNγ only (P < 0...
October 12, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/30312750/bdnf-as-a-pharmacogenetic-target-for-antipsychotic-treatment-of-schizophrenia
#20
REVIEW
Mei Han, Chao Deng
Antipsychotic drugs remain the mainstay of pharmacotherapy for schizophrenia. As there are large individual variations in efficacy and side-effects of antipsychotic drugs, there is a strong demand for personalized medication to treat schizophrenia. Pharmacogenetic research into antipsychotic drugs has examined a number of genetic variants and only a few polymorphisms have been found which promise to be associated with the therapeutic efficacy and side-effects of antipsychotic drugs. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a major role in neurogenesis and neuroplasticity, and in the modulation of several neurotransmitter systems including the dopaminergic system involved in the pathophysiology of schizophrenia...
October 9, 2018: Neuroscience Letters
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