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https://www.readbyqxmd.com/read/29160947/thymic-function-is-a-major-determinant-of-antibody-mediated-rejection-onset-in-heart-transplantation
#1
A Sannier, N Stroumza, G Caligiuri, M Le Borgne-Moynier, F Andreata, J Senemaud, L Louedec, G Even, A T Gaston, C Deschildre, A Couvelard, P Ou, R Cheynier, P Nataf, R Dorent, A Nicoletti
Thymic function progressively decreases with age but may be boosted in certain circumstances. We questioned whether heart transplantation was such a situation and whether the thymic function was related to the onset of rejection. Twenty-eight antithymocyte globulin-treated heart transplant recipients were included. Patients diagnosed for an antibody-mediated rejection on endomyocardial biopsy had higher proportion of circulating recent thymic emigrant CD4+ T cells and T cell receptor excision circle levels than other transplanted subjects...
November 21, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29160552/cotton-rats-sigmodon-hispidus-possess-pharyngeal-pouch-remnants-originating-from-different-primordia
#2
Teppei Nakamura, Osamu Ichii, Takao Irie, Tatsuya Mizoguchi, Akio Shinohara, Hirokazu Kouguchi, Yuji Sunden, Saori Otsuka-Kanazawa, Yaser Hosny Ali Elewa, Chihiro Koshimoto, Ken-Ichi Nagasaki, Yasuhiro Kon
Pharyngeal pouches in mammals develop into specific derivatives. If the differentiation of the pharyngeal pouches is anomalous, their remnants can result in cysts, sinuses, and fistulae in the differentiated organs or around the neck. In the present study, we found several pharyngeal pouch remnants, such as cystic structures in thymus and parathyroid gland and fossulae extended from the piriform fossa, in the inbred cotton rats maintained at Hokkaido Institute of Public Health (HIS/Hiph) and University of Miyazaki (HIS/Mz)...
November 21, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29156526/combined-use-of-insoluble-%C3%AE-glucan-from-the-cell-wall-of-candida-albicans-and-cyclophosphamide-validation-in-s180-tumor-bearing-mice
#3
Yan Qi, Xin Hu, Jin Cui, Jing Chen, Qian Wu, Xiao Sun, Yan Shi
BACKGROUND: Cyclophosphamide (CTX) is a widely used antitumor drug that can suppress the immune system. The effects of regulating immune response and antitumor of β-glucan from the cell wall of Candida albicans (CAIBG) have been confirmed. However, the effects of the combined use of CAIBG and CTX remain unclear and warrant further investigation. METHODS: S180 tumor-bearing models were developed for CAIBG (100 mg/10 mL/kg) and CTX (30 mg/10 mL/kg) intervention...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156522/the-prevention-of-tnf-%C3%AE-ifn-%C3%AE-mixture-induced-inflammation-in-human-keratinocyte-and-atopic-dermatitis-like-skin-lesions-in-nc-nga-mice-by-mineral-balanced-deep-sea-water
#4
Kyu-Shik Lee, So-Young Chun, Min-Gu Lee, Soyoung Kim, Tae-Jung Jang, Kyung-Soo Nam
Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by environmental and chemical allergens. Despite the complexity of its pathogenesis, many investigations have shown that substances having anti-inflammatory activities alleviated the pathology of AD. Here, we evaluated the effects of mineral-balanced deep sea water (DSW) on AD-like skin damage in both in vitro and in vivo. The results showed that mineral-balanced DSW regressed inflammatory chemokines, such as macrophage-derived chemokine (MDC), thymus- and activation-regulated chemokine (TARC) and regulated on activation, normal T-cell expressed and secreted (RANTES), and cytokines, interleukin (IL)-6 and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA expression in HaCaT immortal human keratinocyte treated with tumor necrosis factor (TNF)-α/ interferon (IFN)-γ mixture...
November 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29152635/profiling-polyphenol-composition-by-hplc-dad-esi-msn-and-the-antibacterial-activity-of-infusion-preparations-obtained-from-four-medicinal-plants
#5
Borhane E C Ziani, Lillian Barros, Ali Z Boumehira, Khaldoun Bachari, Sandrina A Heleno, Maria Jose Alves, Isabel C F R Ferreira
The infusions of Thymus pallescens Noë, Saccocalyx satureioides Coss. et Dur., Ptychotis verticillata Briq. and Limoniastrum guyonianum Boiss. have been used as medicinal remedies for many diseases in Algerian folk medicine. These species have also been well documented as rich sources of phytochemicals, such as phenolic compounds with wide diversified chemical structures, which exhibit far-ranging biological activities. Thus, the phenolic compound profile of the aqueous extracts, obtained by infusing, of the mentioned species was obtained by HPLC-DAD-ESI/MS, and their antibacterial activity was evaluated against clinical isolates...
November 20, 2017: Food & Function
https://www.readbyqxmd.com/read/29148973/the-somatically-generated-portion-of-the-t-cell-receptor-cdr3%C3%AE-contributes-to-the-mhc-allele-specificity-of-the-t-cell-receptor
#6
Philippa Marrack, Sai Harsha Krovi, Daniel Silberman, Janice White, Eleanor Kushnir, Maki Nakayama, James Crooks, Thomas Danhorn, Sonia Leach, Randy Anselment, James Scott-Browne, Laurent Gapin, John Kappler
Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. The structural basis for positive selection has long been debated. Here, using mice expressing one of two different T cell receptor β chains and various MHC alleles, we show that positive selection-induced MHC bias of T cell receptors is affected both by the germline encoded elements of the T cell receptor α and β chain and, surprisingly, dramatically affected by the non germ line encoded portions of CDR3 of the T cell receptor α chain...
November 17, 2017: ELife
https://www.readbyqxmd.com/read/29144837/evolution-of-alternative-adaptive-immune-systems-in-vertebrates
#7
Thomas Boehm, Masayuki Hirano, Stephen J Holland, Sabyasachi Das, Michael Schorpp, Max D Cooper
Adaptive immunity in jawless fishes is based on antigen recognition by three types of variable lymphocyte receptors (VLRs) composed of variable leucinerich repeats, which are differentially expressed by two T-like lymphocyte lineages and one B-like lymphocyte lineage. The T-like cells express either VLRAs or VLRCs of yet undefined antigen specificity, whereas the VLRB antibodies secreted by B-like cells bind proteinaceous and carbohydrate antigens. The incomplete VLR germline genes are assembled into functional units by a gene conversion-like mechanism that employs flanking variable leucine-rich repeat sequences as templates in association with lineage-specific expression of cytidine deaminases...
November 16, 2017: Annual Review of Immunology
https://www.readbyqxmd.com/read/29144601/anti-bacterial-anti-biofilm-and-anti-quorum-sensing-effects-of-thymus-daenensis-and-satureja-hortensis-essential-oils-against-staphylococcus-aureus-isolates
#8
Aram Sharifi, Abdolmajid Mohammadzadeh, Taghi Zahraei Salehi, Pezhman Mahmoodi
AIMS: The present study was conducted to investigate the effects of Thymus daenensis and Satureja hortensis essential oils (EOs) on the planktonic growth, biofilm formation and quorum sensing (QS) of some Staphylococcus aureus isolates (strong biofilm producers). METHODS AND RESULTS: MIC of the EOs, inhibition of biofilm formation as well as disruption of preformed S. aureus biofilms were assessed. The anti-biofilm activity of the EOs was determined using microtiter-plate test (MtP) and scanning electron microscope (SEM)...
November 16, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29143106/nonsuppressing-normal-thymus-on-chemical-shift-mr-imaging-and-anterior-mediastinal-lymphoma-differentiation-with-diffusion-weighted-mr-imaging-by-using-the-apparent-diffusion-coefficient
#9
Adriano Massimiliano Priola, Sandro Massimo Priola, Dario Gned, Maria Teresa Giraudo, Andrea Veltri
OBJECTIVES: To prospectively evaluate usefulness of the apparent diffusion coefficient (ADC) in differentiating anterior mediastinal lymphoma from nonsuppressing normal thymus on chemical-shift MR, and to look at the relationship between patient age and ADC. METHODS: Seventy-three young subjects (25 men, 48 women; age range, 9-29 years), who underwent chemical-shift MR and diffusion-weighted MR were divided into a normal thymus group (group A, 40 subjects), and a lymphoma group (group B, 33 patients)...
November 15, 2017: European Radiology
https://www.readbyqxmd.com/read/29142150/effect-of-maternal-supplementation-with-seaweed-powder-on-immune-status-of-liver-and-lymphoid-organs-of-piglets
#10
Ahmad Farid Nikmal Azizi, Ryoko Miyazaki, Takeru Yumito, Yuki Ohashi, Susumu Uno, Umi Miyajima, Mayu Kumamoto, Shinji Uchiyama, Masahiro Yasuda
This study was performed to evaluate the effect of maternal supplementation with seaweed powder (SWP) on the immune status of piglets. Sows were supplementary fed SWP from 85-days of gestation until delactation. Forty-days old piglets were euthanized and lymphocyte subsets were analyzed. The results showed a significantly higher relative population of CD4(+)CD8(+) T cells in the thymus, lymph node, tonsil (P<0.05), peripheral blood mononuclear cells, spleen and liver (P<0.01) of piglets derived from treated sows...
November 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29141868/geographic-clonal-tracking-in-macaques-provides-insights-into-hspc-migration-and-differentiation
#11
Chuanfeng Wu, Diego A Espinoza, Samson J Koelle, E Lake Potter, Rong Lu, Brian Li, Di Yang, Xing Fan, Robert E Donahue, Mario Roederer, Cynthia E Dunbar
The geographic distribution of hematopoiesis at a clonal level is of interest in understanding how hematopoietic stem and progenitor cells (HSPCs) and their progeny interact with bone marrow (BM) niches during regeneration. We tagged rhesus macaque autologous HSPCs with genetic barcodes, allowing clonal tracking over time and space after transplantation. We found marked geographic segregation of CD34(+) HSPCs for at least 6 mo posttransplantation, followed by very gradual clonal mixing at different BM sites over subsequent months to years...
November 15, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29136677/thymus-growth-and-fetal-immune-responses-in-diabetic-pregnancies
#12
Katharina Warncke, Ramona Lickert, Stephanie Eitel, Karl-Philipp Gloning, Ezio Bonifacio, Eva-Maria Sedlmeier, Petra Becker, Jan Knoop, Andreas Beyerlein, Anette-Gabriele Ziegler
Type 1 diabetes (T1D) during pregnancy possibly affects the development of the thymus and the maturation of the immune system in the offspring. The aim of the ImmunDiabRisk study was to investigate thymus growth and maternal and fetal immune responses in pregnancies with and without T1D. The thymus circumferences of the fetuses of pregnant women with T1D (n=49) and without diabetes (n=59) were measured using ultrasound around the 29th gestational week and standardized for gestational age. Simultaneously, the frequencies and total numbers of cell markers were analyzed by flow cytometry in maternal peripheral blood, and at birth in umbilical cord blood...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29134304/outcome-of-thyroid-carcinoma-showing-thymus-like-differentiation-in-patients-undergoing-radical-resection
#13
Wenwu Dong, Ping Zhang, Jian Li, Liang He, Zhihong Wang, Ting Zhang, Liang Shao, Hao Zhang
BACKGROUND: Carcinoma showing thymus-like differentiation (CASTLE) is a rare malignant tumor of the thyroid. It is difficult to diagnose, and there is no universally recognized therapeutic regimen. This study aims to define the clinicopathological features and discuss the optimal management of CASTLE. METHODS: We retrospectively analyzed six patients with CASTLE who accepted surgery at the First Hospital of China Medical University between January 2010 and December 2015...
November 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29133038/new-metalo-therapeutics-of-nsaids-against-human-breast-cancer-cells
#14
Christina N Banti, Constantina Papatriantafyllopoulou, Anastasios J Tasiopoulos, Sotiris K Hadjikakou
The non steroidal anti-inflammatory drugs (NSAID's)-silver(I) metallodrugs of aspirin (aspH), salicylic acid (salH2), naproxen (napH) acid or p-hydrobenzoic acid (pHbzaH) and the mitochondriotropic triphenylarsine (tpAs) with the formulae [Ag(asp)(tpAs)3] (1), [Ag(salH)(tpAs)3] (2), [Ag(nap)(tpAs)3] (3) and {[Ag(pHbza)(tpAs)3]∙(dmf)} (4) and [Ag(tpAs)3(NO3)] (5) have been synthesized and characterized by m.p., FT-IR, UV-vis and (1)H NMR, spectroscopic techniques and X-ray crystallography. The in vitro cytotoxic activity of 1-5 against human breast adenocarcinoma cancer cells: MCF-7 (positive to estrogen receptors (ERs)) and MDA-MB-231 (negative to estrogen receptors (ERs)) was evaluated...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29132721/endocrine-pathology-past-present-and-future
#15
REVIEW
Sylvia L Asa, Ozgur Mete
Endocrine pathology is the subspecialty of diagnostic pathology which deals with the diagnosis and characterisation of neoplastic and non-neoplastic diseases of the endocrine system. This relatively young subspecialty was initially focused mainly on thyroid and parathyroid pathology, with some participants also involved in studies of the pituitary, the endocrine pancreas, and the adrenal glands. However, the endocrine system involves much more than these traditional endocrine organs and the discipline has grown to encompass lesions of the dispersed neuroendocrine cells, including neuroendocrine tumours (NETs) of the lungs, gastrointestinal tract, thymus, breast and prostate, as well as paraganglia throughout the body, not just in the adrenals...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29132253/new-binary-copper-ii-complexes-containing-intercalating-ligands-dna-interactions-an-unusual-static-quenching-mechanism-of-bsa-and-cytotoxic-activities
#16
Duygu İnci, Rahmiye Aydın, Özgür Vatan, Yunus Zorlu, Nilüfer Çinkılıç
New binary copper(II) complexes, - [Cu(4-mphen)2(NO3)]NO3·H2O (1), [Cu(5-mphen)2 (NO3)]NO3·H2O (2), the known complex [Cu(dmphen)2(NO3)]NO3 (3) and [Cu(tmphen)2 (NO3)]NO3·H2O (4) - (4-mphen: 4-methyl-1,10-phenanthroline, 5-mphen: 5-methyl-1,10-phenanthroline, dmphen: 4,7-dimethyl-1,10-phenanthroline, tmphen: 3,4,7,8-tetramethyl-1,10-phenanthroline), have been synthesized and characterized by CHN analysis, ESI-MS, FTIR and single-crystal X-ray diffraction techniques. Interaction of these complexes with calf thymus DNA (CT-DNA) has been investigated by absorption spectral titration, ethidium bromide (EB) and Hoechst 33258 displacement assay and thermal denaturation measurement...
November 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29130341/topoisomerases-inhibitory-activities-and-dna-binding-properties-of-9-methoxycamptothecin-from-nothapodytes-nimmoniana-j-graham-mabberly
#17
Haiyan Wang, Mingzhang Ao, Weitu Liu, Yun Bai, Yuanmin Zhu, Longjiang Yu
We have reported previously that 9-methoxycamptothecin (MCPT) showed significant antitumor activity in vitro. Here, agarose gel electrophoresis experiments were performed to evaluate MCPT's unwinding ability toward plasmid DNA and inhibitory activities against topoisomerases (Topo) I and II. Binding properties of MCPT to calf thymus DNA (CT-DNA) were evaluated by UV-vis, melting temperature, fluorescence, circular dichroism methodologies and molecular docking technique. Results showed that MCPT at 100 μM inhibited Topo I activity, but had no effect on Topo II...
November 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29128705/1-3-di-n-butylimidazolium-tribromide-bbim-br3-an-efficient-recyclable-catalyst-mediated-synthesis-of-n-substituted-azepines-and-their-biological-evaluation-interaction-study-with-human-serum-albumin
#18
Swetha K Maddili, Rakhi Chowrasia, Vijaya Kumar Kannekanti, Himabindu Gandham
A majority of previously reported methods suffer from insufficient yields as well as more complicated experimental procedures, a smaller amount of isolated yields involving time-consuming and tiresome work-up with the use of metal catalyst and restricted scope of substrates. To overcome these issues, an environmentally benign, ionic liquid endorsed multi-component protocol to N-substituted azepines has been exploited by means of coupling aromatic amines, dimethyl/diethyl acetylene dicarboxylate, 2,5-dimethoxytetrahydrofuran using 1,3-Di-n-butylimidazolium tribromide [BBim]Br3...
November 2, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29128573/26-week-oral-chronic-toxicity-study-of-geniposide-in-rats
#19
Jingzhuo Tian, Yan Yi, Yong Zhao, Chunying Li, Yushi Zhang, Lianmei Wang, Chen Pan, Jiayin Han, Guiqin Li, Xiaolong Li, Jing Liu, Nuo Deng, Yue Gao, Aihua Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Geniposide, the major active constituent of Fructus Gardeniae (FG), has been widely used to treat the various diseases in China. AIM OF THE STUDY: The chronic toxicity study was conducted to investigate the safety of Geniposide. MATERIALS AND METHODS: Sprague-Dawley (SD) rats of both sexes were administered orally Geniposide 25, 50, 100mg/kg by gavage once daily at volume of 10mL/kg for 26 weeks repeated. Endpoints evaluated included clinical observations, food consumption, body weights, blood biochemistry, hematology, and histomorphological observation...
November 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29126749/corrigendum-to-efficacy-of-e2-glycoprotein-fused-to-porcine-cd154-as-a-novel-chimeric-subunit-vaccine-to-prevent-classical-swine-fever-virus-vertical-transmission-in-pregnant-sows
#20
Sara Muñoz-González, Yusmel Sordo, Marta Pérez-Simó, Marisela Suarez, Albert Canturri, Maria Pilar Rodriguez, María Teresa Frías-Lepoureau, Mariano Domingo, Mario Pablo Estrada, Llilianne Ganges
Here we evaluated the effect of double vaccination with a novel subunit marker vaccine candidate based in the CSFV E2 glycoprotein fused to the porcine CD154 to prevent CSFV vertical transmission. A lentivirus-based gene delivery system was used to obtain a stable recombinant HEK 293 cell line for the expression of E2 fused to porcine CD154 molecule. Six pregnant sows were distributed in two groups and at 64days of gestation animals numbered 1-4 (group 1) were vaccinated via intramuscular inoculation with 50μg of E2-CD154 subunit vaccine...
November 7, 2017: Veterinary Microbiology
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