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https://www.readbyqxmd.com/read/28543682/residual-thymic-tissue-and-lymph-node-involvement-by-acute-myeloid-leukaemia-presenting-as-mediastinal-strongly-18-fdg-pet-positive-masses
#1
Georg Maschmeyer, Ingo Brink, Doris Jähne, Renate Arnold, Olaf Schega
We report on a multidisciplinary management of a 68-year old AML patient presenting with a PET-positive mediastinal tumour typical for lymph node metastasis. It was removed via minimally invasive thoracoscopic intervention and was identified as a thymus residual infiltrated by AML. Follow-up PET-CT scan after resection and remission induction chemotherapy was completely normal. To our knowledge, this is the first documented case report of AML presenting with PET-positive infiltrates of thymic and lymph node tissue along the aortic bow mimicking a second intrathoracic malignancy...
May 22, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28540653/il-2-and-il-15-dependent-thymic-development-of-foxp3-expressing-regulatory-t-lymphocytes
#2
REVIEW
Cécile Apert, Paola Romagnoli, Joost P M van Meerwijk
Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15...
May 24, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28540651/biologically-active-cu-ii-co-ii-ni-ii-and-zn-ii-complexes-of-pyrimidine-derivative-schiff-base-dna-binding-antioxidant-antibacterial-and-in-vitro-anticancer-studies
#3
Nagaraj Revathi, Murugesan Sankarganesh, Jegathalaprathaban Rajesh, Jeyaraj Dhaveethu Raja
A new pyrimidine derivative Schiff base ligand (HL) [HL = 2-(4,6-dimethylpyrimidin-2-ylimino)methyl)-4-nitrophenol] and its metal(II) complexes [CuL2] (1), [CoL2] (2), [NiL2] (3) and [ZnL2] (4) have been synthesized and characterized by several spectral techniques. The square planar geometry of the complexes 1-4 confirmed by UV-Visible, ESR and EI-mass spectral techniques. DNA binding study of the complexes 1-4 with Calf Thymus (CT) DNA using absorption spectral titration at different pH (4.0, 7.0 & 10.0) have been scrutinized that the complexes 1-4 bound by groove binding mode with significant binding constant values (K b  = 5...
May 24, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28539439/contribution-of-human-lung-parenchyma-and-leukocyte-influx-to-oxidative-stress-and-immune-mediated-pathology-following-nipah-infection
#4
Olivier Escaffre, Tais B Saito, Terry L Juelich, Tetsuro Ikegami, Jennifer K Smith, David D Perez, Colm Atkins, Corri B Levine, Matthew B Huante, Rebecca J Nusbaum, Janice J Endsley, Alexander N Freiberg, Barry Rockx
Nipah virus (NiV) is a zoonotic emerging paramyxovirus that can cause a fatal respiratory illness or encephalitis in humans. Despite many efforts, the molecular mechanisms of NiV-induced acute lung injury (ALI) remain unclear. We previously showed that NiV replicates to high titers in human lung grafts in NOD scid gamma mice, resulting in a robust inflammatory response. Interestingly, these mice can undergo human immune system reconstitution by the Bone marrow, Liver, and Thymus (BLT) reconstitution method, in addition to lung tissue engraftment, giving altogether a realistic model to study human respiratory viral infections...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28539430/physiologic-thymic-involution-underlies-age-dependent-accumulation-of-senescence-associated-cd4-t-cells
#5
Kyosuke Sato, Aiko Kato, Miho Sekai, Yoko Hamazaki, Nagahiro Minato
Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1(+) and CD153(+) CD44(high) CD4(+) T cells with features of cellular senescence, termed senescence-associated T (SA-T) cells, increasingly accumulate with age and may play a role in the immune aging phenotype. In this article, we demonstrate that, compared with young mice, the aged mouse environment is highly permissive for spontaneous proliferation of transferred naive CD4(+) T cells, and it drives their transition to PD-1(+) and CD153(+) CD44(high) CD4(+) T cells after extensive cell divisions...
May 24, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28538410/extrapleural-solitary-fibrous-tumor-in-thymic-area-a-case-report
#6
Eun Kyung Jung, Young Yoon Kim, Dong Hoon Lee, Kyung Hwa Lee, Joon Kyoo Lee
RATIONALE: Solitary fibrous tumor (SFT) is a rare benign soft tissue mesenchymal neoplasm. There have been a few reports of extrapleural SFTs although it can occur anywhere in the body. PATIENT CONCERNS: A 30-year-old male presented with an anterior neck mass since one month. DIAGNOSES: Based on physical and radiologic examination, preliminary differential diagnosis was thymic neoplasm or intrathoracic goiter. INTERVENTIONS: We performed surgical excision of the neck mass...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28536901/increased-epithelial-free-areas-in-thymuses-with-altered-ephb-mediated-thymocyte-thymic-epithelial-cell-interactions
#7
Javier García-Ceca, Sara Montero-Herradón, David Alfaro, Agustín G Zapata
Epithelial-free areas, present in both thymic cortex and medulla, have been studied in WT and EphB-deficient mice that have important alterations in the development of thymic epithelium due to the lack of proper thymocyte-thymic epithelial cell interactions. In both WT and mutant thymuses, the number and size of epithelial-free areas are significantly larger in the medulla than in the cortex. The two parameters show a reverse correlation: low numbers of these areas course with large epithelial-free areas and vice versa...
May 24, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28536579/peripherally-induced-regulatory-t-cells-recruited-protectors-of-the-central-nervous-system-against-autoimmune-neuroinflammation
#8
REVIEW
Andrew Jones, Daniel Hawiger
Defects in regulatory T cells (Treg cells) aggravate multiple sclerosis (MS) after its onset and the absence of Treg cell functions can also exacerbate the course of disease in an animal model of MS. However, autoimmune neuroinflammation in many MS models can be acutely provoked in healthy animals leading to an activation of encephalitogenic T cells despite the induction of immune tolerance in the thymus including thymically produced (t)Treg cells. In contrast, neuroinflammation can be ameliorated or even completely prevented by the antigen-specific Treg cells formed extrathymically in the peripheral immune system (pTreg cells) during tolerogenic responses to relevant neuronal antigens...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28536482/nad-loss-a-new-player-in-ahr-biology-prevention-of-thymus-atrophy-and-hepatosteatosis-by-nad-repletion
#9
Silvia Diani-Moore, Jenny Shoots, Rubi Singh, Joshua B Zuk, Arleen B Rifkind
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) is a carcinogenic and highly toxic industrial byproduct that persists in the environment and produces a pleiotropic toxicity syndrome across vertebrate species that includes wasting, hepatosteatosis, and thymus atrophy. Dioxin toxicities require binding and activation of the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor. However, after nearly 50 years of study, it remains unknown how AhR activation by dioxin produces toxic effects...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28535636/-characteristics-of-distribution-and-quantity-of-dendritic-cells-subtypes-in-hyperplastic-thymus-in-patients-with-myasthenia-gravis
#10
H Huang, P Chen, C Y Ou, L Qiu, Z Z Lin, Z D Huang, W B Liu
Objective: To investigate the characteristics of the distribution and amount of different subtypes of dendritic cell (DC) in myasthenia gravis(MG). Methods: We collected the thymic specimens from 32 patients who received thymoctomy because of cardiac surgery from January 2016 to December 2016 and selected 14 of them as normal control. Meantime, 61 MG patients who combined with thymic hyperplasia and received extended thymectomy were collected and selected 8 of them as experiment group.Immunohistochemical methods were used to label the two subtype DCs: plasmacytoid dendritic cell (pDC) and classical/conventional dendritic cell (cDC), to observe the distribution of these two DC subtypes in thymus and also quantify them in different thymus structures by image analysis software...
May 23, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28534439/hypolipidemic-and-hepatoprotective-activities-of-rosemary-and-thyme-in-gentamicin-treated-rats
#11
A M Hegazy, A S Abdel-Azeem, H M Zeidan, K S Ibrahim, Em El Sayed
Rosemary ( Rosmarinus officinalis; RM) and thyme ( Thymus vulgaris; TV) are used as remedies. We designed this work to investigate the preventive effect of aqueous extracts of RM or TV on the gentamicin (GM)-induced hepatotoxicity and abnormalities of lipid profile in rats. Both plant extracts exhibited an in vitro antioxidant activity as determined by the 1,1-diphenyl-2-picrylhydrazyl assay. Radical scavenging activity for TV extract was 48.7% and for RM extract was 25.6%. Polyphenolic determination by high-performance liquid chromatography for both extracts revealed that catechin, coumarin, cinnamic acid and rutin were detected in both extracts...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28534268/impact-of-thyme-powder-thymus-vulgaris-l-supplementation-on-gene-expression-profiles-of-cytokines-and-economic-efficiency-of-broiler-diets
#12
Fardos A M Hassan, Ashraf Awad
This study was conducted in an attempt to evaluate the impact of thyme powder supplementation on broiler diets with respect to cytokine and mucin2 gene expressions. It was also our aim to evaluate the growth performance, blood biochemical and hematological profiles, and economic efficiency of the diet. A total of 120 1-day old chicks (Cobb 500) were divided into four groups on the basis of the diet. One group received a basal diet (control) while the others received a basal diet supplemented with 2, 5, or 8 g/kg of thyme powder...
May 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28531811/synthesis-of-novel-indole-derivatives-as-promising-dna-binding-agents-and-evaluation-of-antitumor-and-antitopoisomerase-i-activities
#13
Elizabeth Almeida Lafayette, Sinara Mônica Vitalino de Almeida, Renata Virginia Cavalcanti Santos, Jamerson Ferreira de Oliveira, Cezar Augusto da Cruz Amorim, Rosali Maria Ferreira da Silva, Maira Galdino da Rocha Pitta, Ivan da Rocha Pitta, Ricardo Olimpio de Moura, Luiz Bezerra de Carvalho Júnior, Moacyr Jesus Barreto de Melo Rêgo, Maria do Carmo Alves de Lima
Molecules bearing indole nucleus present diverse biological properties such as antitumor and anti-inflammatory activities that can be associated both to DNA and protein interactions. This study focused on the synthesis of new indole derivatives with thiazolidines and imidazolidine rings condensed as side chains as well as the evaluation of their ability to interact with the DNA and antitumor and topoisomerase inhibition activities. All derivatives were successfully synthesized and their structures were elucidated by mass spectrometry (MS), infrared (IR), spectroscopy (1)H NMR, (13)C NMR, COSY (1)H-(1)H and HSQC (1)H-(13)C...
May 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28530714/cd8%C3%AE-%C3%AE-intraepithelial-lymphocytes-arise-from-two-main-thymic-precursors
#14
Roland Ruscher, Rebecca L Kummer, You Jeong Lee, Stephen C Jameson, Kristin A Hogquist
TCRαβ(+)CD4(-)CD8α(+)CD8β(-) intestinal intraepithelial lymphocytes (CD8αα IELs) are an abundant population of thymus-derived T cells that protect the gut barrier surface. We sought to better define the thymic IEL precursor (IELp) through analysis of its maturation, localization and emigration. We defined two precursor populations among TCRβ(+)CD4(-)CD8(-) thymocytes by dependence on the kinase TAK1 and rigorous lineage-exclusion criteria. Those IELp populations included a nascent PD-1(+) population and a T-bet(+) population that accumulated with age...
May 22, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28529567/fuzheng-qingjie-granules-potentiate-the-anticancer-effect-of-cyclophosphamide-by-regulating-cellular-immune-function-and-inducing-apoptosis-in-hepatoma-22-tumor-bearing-mice
#15
Xu-Zheng Chen, Zhi-Yun Cao, You-Quan Zhang, Jin-Nong Li, Lian-Ming Liao, Jian Du
Fuzheng Qingjie (FZQJ) is a polyherbal Chinese medicine that has previously been implemented as an adjuvant therapy for gastrointestinal cancer. The present study investigated whether FZQJ is able to potentiate the anticancer effect of cyclophosphamide (CTX). Hepatoma 22 tumor-bearing mice were randomly divided into a vehicle group, CTX group, FZQJ group and combination (CTX+FZQJ) group. In addition, untreated mice without H22 cells served as blank controls. Seven days post-treatment, the mice were sacrificed and the tumors were weighed...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28529467/radiotherapy-for-pertussis-an-historical-assessment
#16
Edward J Calabrese, Gaurav Dhawan, Rachna Kapoor
X-ray therapy was used to treat pertussis/whooping cough during a 13-year period from 1923 to 1936 in North America and Europe. Twenty studies from clinicians in the United States reported that approximately 1500 cases of pertussis were treated by X-ray therapy usually with less than 0.5 erythema dose. Young children (<3 years) comprised about 70% to 80% of the cases, with the age of cases ranging from as young as 1 month to 50 years. In general, symptoms of severe coughing, vomiting episodes, and spasms were significantly relieved in about 85% of cases following up to 3 treatments, while about 15% of the cases showed nearly full relief after only 1 treatment...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28528094/encapsulated-thyme-thymus-vulgaris-essential-oil-used-as-a-natural-preservative-in-bakery-product
#17
Nathalia Dias Gonçalves, Fabíola de Lima Pena, Adilson Sartoratto, Camila Derlamelina, Marta Cristina Teixeira Duarte, Adriane Elisabete Costa Antunes, Ana Silvia Prata
The objective of this work was to design a particle using thyme (Thymus vulgaris) essential oil through complex coacervation. In vitro activity against bacteria and molds of free oil as well as the encapsulated oil was verified and then in situ assay was done. The free thyme oil presented high in vitro activity, with values below 0.50mg/mL for almost all the microorganisms tested. Also, MIC values for the encapsulated oil was lower than for the free oil, probably due to the protective micro-environment promoted by the particle wall...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28527395/hydrogen-bonded-charge-transfer-molecular-salt-4-chloro-anilinium-3-nitrophthalate-for-photophysical-and-pharmacological-applications
#18
K Singaravelan, A Chandramohan, M Saravanabhavan, I V Muthu Vijayan Enoch, V S Suganthi
Radical scavenging activity against DPPH radical and binding properties of a hydrogen bonded charge transfer molecular salt 4-chloro anilinium-3-nitrophthalate(CANP) with calf thymus DNA has been studied by electronic absorption and emission spectroscopy. The molecular structure and crystallinity of the CANP salt have been established by carried out powder and single crystal X-ray diffraction analysis which indicated that cation and anion are linked through strong N(+)H(…)O(-) type of hydrogen bond. FTIR spectroscopic study was carried out to know the various functional groups present in the crystal...
May 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28525342/effects-of-long-term-construction-noise-on-health-of-adult-female-wistar-rats
#19
J Zymantiene, R Zelvyte, I Pampariene, A Aniuliene, N Juodziukyniene, J Kantautaite, V Oberauskas
The aim of this study was to investigate the influence of long-term building construction noise from refurbishment, which including vibration, on some physiological parameters and histopathological changes of organs of Wistar rats. Twenty 12 month old female rats were divided into two groups: rats group I (n = 10) were exposed to long-term construction noise and rats group II (n = 10) were kept under normal noise level. Study results revealed that long-term construction noise from building refurbishment has an influence on body weight, haematological and some serum biochemical parameters affects caecal microbiota, and causes histopathological changes in the organs of adult female Wistar rats...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28525298/experimental-and-computational-evidence-on-the-interaction-of-cycloalkyl-%C3%AE-aminobisphosphonates-with-calf-thymus-dna
#20
Mohammad Bagher Gholivand, Hossein Peyman, Khodayar Gholivand, Hamideh Roshanfekr, Avat Arman Taherpour, Rouhollah Yaghoubi
Fluorescence spectroscopy, ultraviolet-visible absorption spectroscopy, circular dichroism spectroscopy, viscometry, cyclic voltammetry, and differential pulse voltammetry were applied to investigate the competitive interaction of DNA with the three new cycloalkyl α-aminobisphosphonates (D1-D3) and spectroscopic probe, neutral red dye, and Hoechst (HO), in a Tris-hydrogen chloride buffer (pH 7.4). The spectroscopic and voltammetric studies showed that the groove binding mode of interaction is predominant in the solution containing DNA and α-aminobisphosphonates...
May 19, 2017: DNA and Cell Biology
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