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https://www.readbyqxmd.com/read/28718793/detection-of-guanine-and-adenine-using-an-aminated-reduced-graphene-oxide-functional-membrane-modified-glassy-carbon-electrode
#1
Di Li, Xiao-Lu Yang, Bao-Lin Xiao, Fang-Yong Geng, Jun Hong, Nader Sheibani, Ali Akbar Moosavi-Movahedi
A new electrochemical sensor based on a Nafion, aminated reduced graphene oxide and chitosan functional membrane-modified glassy carbon electrode was proposed for the simultaneous detection of adenine and guanine. Fourier transform-infrared spectrometry (FTIR), transmission electron microscopy (TEM), and electrochemical methods were utilized for the additional characterization of the membrane materials. The prepared electrode was utilized for the detection of guanine (G) and adenine (A). The anodic peak currents to G and A were linear in the concentrations ranging from 0...
July 18, 2017: Sensors
https://www.readbyqxmd.com/read/28716889/cytokines-transcription-factors-and-the-initiation-of-t-cell-development
#2
Hiroyuki Hosokawa, Ellen V Rothenberg
Multipotent blood progenitor cells migrate into the thymus and initiate the T-cell differentiation program. T-cell progenitor cells gradually acquire T-cell characteristics while shedding their multipotentiality for alternative fates. This process is supported by extracellular signaling molecules, including Notch ligands and cytokines, provided by the thymic microenvironment. T-cell development is associated with dynamic change of gene regulatory networks of transcription factors, which interact with these environmental signals...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28715672/genomic-and-pathogenic-analysis-of-a-muscovy-duck-parvovirus-strain-causing-short-beak-and-dwarfism-syndrome-without-tongue-protrusion
#3
Qiuling Fu, Yu Huang, Chunhe Wan, Guanghua Fu, Baomin Qi, Longfei Cheng, Shaohua Shi, Hongmei Chen, Rongchang Liu, Zhenhai Chen
In 2008, clinical cases of short beak and dwarfism syndrome (SBDS) caused by Muscovy duck parvovirus (MDPV) infection were found in mule duck and Taiwan white duck farms in Fujian, China. A MDPV LH strain causing duck SBDS without tongue protrusion was isolated in this study. Phylogenetic analysis show that the MDPV LH strain was clustered together with other MDPV strains, but divergent from GPV isolates. Two major fragment deletions were found in the inverted terminal repeats (ITR) of MDPV LH similar to the ones in the ITR of MDPV GX5, YY and SAAS-SHNH strains...
July 12, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28714250/development-of-antimicrobial-nanoemulsion-based-delivery-systems-against-selected-pathogenic-bacteria-using-a-thymol-rich-thymus-daenensis-essential-oil
#4
Lida Ghaderi, Roya Moghimi, Atousa Aliahmadi, David Julian McClements, Hasan Rafati
AIMS: Thymol rich medicinal plants have been used in traditional medicine to relieve infectious diseases. However, the application of essential oils as medicine is limited by its low water-solubility and high vapor pressure. The objective of this study was to produce stable nanoemulsions of Thymus daenensis oil in water by preventing Ostwald ripening and phase separation. METHODS & RESULTS: The antibacterial activity of bulk and emulsified essential oil against selected pathogenic bacteria including Gram-negative (Haemophilus influenzae, Pseudomonas aeruginosa) and Gram-positive (Streptococcus pneumoniae) were investigated in the liquid and vapor phase...
July 17, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28708784/apoptotic-diminution-of-immature-single-and-double-positive-thymocyte-subpopulations-contributes-to-thymus-involution-during-murine-polymicrobial-sepsis
#5
Christoph Netzer, Tilo Knape, Laura Kuchler, Andreas Weigert, Kai Zacharowski, Waltraud Pfeilschifter, Gregory Sempowski, Michael J Parnham, Bernhard Brüne, Andreas von Knethen
To generate and maintain functional T-cell receptor diversity, thymocyte development is tightly organized. Errors in this process may have dramatic consequences, provoking, for example, autoimmune diseases. Probably for this reason, the thymus reacts to septic stress with involution, decreasing the numbers of thymocytes. Because it is still unclear which thymocyte subpopulation contributes to thymus involution and whether thymocyte emigration is altered, we were interested to clarify this question in detail...
August 2017: Shock
https://www.readbyqxmd.com/read/28708465/synthesis-characterization-redox-behavior-dna-and-protein-binding-and-antibacterial-activity-studies-of-ruthenium-ii-complexes-of-bidentate-schiff-bases
#6
Hena Paul, Buddhadeb Sen, Tapan Kumar Mondal, Pabitra Chattopadhyay
Two new ruthenium(II) complexes of Schiff base ligands (L) derived from cinnamaldehyde and ethylenediamine formulated as [Ru(L)(bpy)2](ClO4)2, where L(1) = N,N'-bis(4-nitrocinnamald-ehyde)ethylenediamine and L(2) = N,N'-bis(2-nitrocinnamaldehyde)-ethylenediamine for complex 1 and 2, respectively, were isolated in pure form. The complexes were characterized by physicochemical and spectroscopic methods. The electrochemical behavior of the complexes showed the Ru(III)/Ru(II) couple at different potentials with quasi-reversible voltammograms...
July 14, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/28707480/in-ovo-silver-nanoparticle-supplementation-for-improving-the-post-hatch-immunity-status-of-broiler-chickens
#7
Akshat Goel, Subrat Kumar Bhanja, Manish Mehra, Samir Majumdar, Asitbaran Mandal
Silver nanoparticles (AgNano) are known for their unique physical, chemical and biological properties, enabling cell penetration and anti-inflammatory response. In Experiment 1, the effect of an in ovo administration of AgNano (15 µg/egg; n = 360) at different incubation times (d 7 and d 18) on hatchability parameters was explored. In Experiment 2, post-hatch performance of broilers (42 d, n = 250) was studied after in ovo AgNano administration: Group T1 remained un-injected, Group T2 was the sham control and Groups T3, T4 and T5 were injected with 12...
July 14, 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28707128/thymectomy-is-a-beneficial-therapy-for-patients-with-non-thymomatous-ocular-myasthenia-gravis-a-systematic-review-and-meta-analysis
#8
Kai Zhu, Jiaoxing Li, Xin Huang, Wei Xu, Weibin Liu, Jiaxin Chen, Pei Chen, Huiyu Feng
Ocular myasthenia gravis, an autoimmune disease, is characterized by extraocular muscle weakness. Myasthenia gravis is closely associated with the functional status of the thymus gland. The efficacy of thymectomy for non-thymomatous ocular myasthenia gravis remains controversial. Here, we present the first systematic review and meta-analysis of studies assessing the outcome of thymectomy in patients with non-thymomatous ocular myasthenia gravis and found that the pooled rate of complete stable remission was 0...
July 13, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28705510/the-chemical-composition-of-the-pharmacologically-active-thymus-species-its-antibacterial-activity-against-streptococcus-mutans-and-the-antiadherent-effects-of-t-vulgaris-on-the-bacterial-colonization-of-the-in-situ-pellicle
#9
Gesche Schött, Stefanie Liesegang, Franziska Gaunitz, Alexandra Gleß, Sabine Basche, Christian Hannig, Karl Speer
The pharmacological active genus Thymus L. comprises over 200 species. Besides its traditional pharmacological use, thyme may reduce the risk of caries disease, however, there is very little respective literature. The pharmacological effects can be attributed to the secondary plant metabolites. The composition of the essential oil and the polyphenols is important for the evaluation of the pharmacological activity. Nevertheless, there are no studies regarding a comparative analysis of the different pharmacological thyme species...
July 10, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28704827/age-dependent-changes-in-regulatory-t-lymphocyte-development-and-function-a-mini-review
#10
Julie Darrigues, Joost P M van Meerwijk, Paola Romagnoli
The generation and function of immuno-suppressive regulatory T lymphocytes (Treg), which can differentiate in the thymus (tTreg) or in the periphery (pTreg), are regulated in an age-dependent manner. tTreg are produced at high levels in the first weeks of age, when they expand and colonize secondary lymphoid organs and peripheral tissues to protect the organism from autoimmune diseases and to promote tissue repair. Once this population of Treg is operational in the periphery, at puberty, thymic output of Treg declines, but self-reactive tTreg generated early on in life are maintained over time and play a major role in preserving homeostasis of the immune system...
July 14, 2017: Gerontology
https://www.readbyqxmd.com/read/28704723/highly-sensitive-determination-of-fatty-acid-esters-of-hydroxyl-fatty-acids-by-liquid-chromatography-mass-spectrometry
#11
Quan-Fei Zhu, Jing-Wen Yan, Yang Gao, Jing-Wei Zhang, Bi-Feng Yuan, Yu-Qi Feng
Recently, a new class of endogenous lipids, branched fatty acid esters of hydroxy fatty acids (FAHFAs), was discovered with anti-diabetic and anti-inflammatory effects in mammals. FAHFAs attracted increasing attention because of their critical physiological function. However, accurate quantitation of FAHFAs is still a challenge due to their high structure similarity and low abundance in biological samples. Herein, we developed a highly sensitive method for the determination of 16 FAHFAs (PAHSAs, OAHSAs, SAHSAs and POHSAs) in biological samples by coupling strong anion exchange solid phase extraction (SAX-SPE) with chemical labeling assisted ultra-high performance liquid chromatography/mass spectrometry (SAX-SPE-CL-UHPLC/MS)...
June 27, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28702458/cocoa-diet-and-antibody-immune-response-in-preclinical-studies
#12
REVIEW
Mariona Camps-Bossacoma, Malen Massot-Cladera, Mar Abril-Gil, Angels Franch, Francisco J Pérez-Cano, Margarida Castell
The ability of cocoa to interact with the immune system in vitro and in vivo has been described. In the latter context, a cocoa-enriched diet in healthy rats was able to modify the immune system's functionality. This fact could be observed in the composition and functionality of lymphoid tissues, such as the thymus, spleen, and lymph nodes. Consequently, immune effector mechanisms, such as antibody synthesis, were modified. A cocoa-enriched diet in young rats was able to attenuate the serum levels of immunoglobulin (Ig) G, IgM, and IgA and also the intestinal IgM and IgA secretion...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28702321/a-high-content-small-molecule-screen-identifies-novel-inducers-of-definitive-endoderm
#13
Alexander Korostylev, Pallavi U Mahaddalkar, Oliver Keminer, Kamyar Hadian, Kenji Schorpp, Philip Gribbon, Heiko Lickert
OBJECTIVES: Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can generate any given cell type in the human body. One challenge for cell-replacement therapy is the efficient differentiation and expansion of large quantities of progenitor cells from pluripotent stem cells produced under good manufacturing practice (GMP). FOXA2 and SOX17 double positive definitive endoderm (DE) progenitor cells can give rise to all endoderm-derived cell types in the thymus, thyroid, lung, pancreas, liver, and gastrointestinal tract...
July 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28700666/effects-of-kluyveromyces-marxianus-supplementation-on-immune-responses-intestinal-structure-and-microbiota-in-broiler-chickens
#14
Weiwei Wang, Zhui Li, Zengpeng Lv, Beibei Zhang, Hong Lv, Yuming Guo
To investigate the effects of Kluyveromyces marxianus on immune responses, intestinal structure and microbiota in broilers, 840 1-d-old broiler chicks were randomly divided into seven groups (eight replicates) and were fed basal diets without or with 0.25, 0.50, 1.0, 1.5, 2.0, and 2.5 g/kg of K. marxianus (2.0×1010 CFU/g). Serum and intestine samples were collected at 21 d of age. The results showed that increasing K. marxianus addition linearly reduced feed conversion ratio but linearly elevated relative thymus weight, as well as quadratically increased serum lysozyme and IgG levels, with the medium dose (1...
2017: PloS One
https://www.readbyqxmd.com/read/28699002/a-bilateral-approach-to-extended-thymectomy-using-the-da-vinci-surgical-system-for-patients-with-myasthenia-gravis
#15
Koji Kawaguchi, Takayuki Fukui, Shota Nakamura, Tetsuo Taniguchi, Kohei Yokoi
PURPOSE: We adopted a bilateral approach to complete robotic extended thymectomy with the excision of the pericardial fat tissue from both sides and analyzed the initial outcomes. METHODS: The patient cart was docked first from the left shoulder side. After dissection of the thymus and right pericardial fat tissue, the cart was temporarily rolled out, and the bed was rotated approximately 90° clockwise. The cart was then re-docked from the right-side shoulder, and extended thymectomy was performed via the left-side approach...
July 11, 2017: Surgery Today
https://www.readbyqxmd.com/read/28698642/progressive-changes-in-cxcr4-expression-that-define-thymocyte-positive-selection-are-dispensable-for-both-innate-and-conventional-%C3%AE-%C3%AE-t-cell-development
#16
Beth Lucas, Andrea J White, Sonia M Parnell, Peter M Henley, William E Jenkinson, Graham Anderson
The ordered migration of immature thymocytes through thymic microenvironments generates both adaptive MHC restricted αβT-cells and innate CD1d-restricted iNKT-cells. While several chemokine receptors and ligands control multiple stages of this process, their involvement during early thymocyte development often precludes direct analysis of potential roles during later developmental stages. For example, because of early lethality of CXCR4(-/-) mice, and stage-specific requirements for CXCR4 in thymus colonisation and pre-TCR mediated selection, its role in thymic positive selection is unclear...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698429/-thymoma-with-multilocular-cystic-change-report-of-a-case
#17
Masanobu Hayakawa, Kazuyuki Oda
A 21-year-old male was pointed out an abnormal shadow on chest X-ray. Chest computed tomography showed a multilocular cystic mass of 10×4×4 cm in size in the anterior mediastinum. The tumor and the left lobe of the thymus was resected by median sternotomy. Pathologically, type AB thymoma as found in the wall of the cyst.
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28694386/a-type-2-cytokine-axis-for-thymus-emigration
#18
Andrea J White, Song Baik, Sonia M Parnell, Amanda M Holland, Frank Brombacher, William E Jenkinson, Graham Anderson
In the thymus, stromal microenvironments support a developmental program that generates mature T cells ready for thymic exit. The cellular and molecular specialization within thymic stromal cells that enables their regulation of specific stages of thymocyte development is poorly understood. Here, we show the thymic microenvironment expresses the type 2 IL-4R complex and is functionally responsive to its known ligands, IL-4 and IL-13. Absence of IL-4Rα limits thymocyte emigration, leading to an intrathymic accumulation of mature thymocytes within medullary perivascular spaces and reduced numbers of recent thymic emigrants...
July 10, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28693498/sirolimus-alters-lung-pathology-and-viral-load-following-influenza-a-virus-infection
#19
Ahmed R Alsuwaidi, Junu A George, Saeeda Almarzooqi, Stacey M Hartwig, Steven M Varga, Abdul-Kader Souid
BACKGROUND: Inhibitors of mTOR, such as sirolimus, have been shown to induce thymus involution and inflammatory lung disease in mice. The latter effect supports the role of this serine/threonine kinase in ameliorating lung inflammation. Other studies have shown sirolimus reduces/delays lung disease associated with various strains of influenza A virus (IAV). Thus, the effects of mTOR inhibitors on influenza infection deserve further studies. METHODS: Here, we examined the changes in lung viral copies, pathology and pulmonary function associated with IAV (A/PR/8/34) infection in mice treated with sirolimus...
July 11, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28692924/experimental-co-infection-of-infectious-bronchitis-and-low-pathogenic-avian-influenza-h9n2-viruses-in-commercial-broiler-chickens
#20
Kareem E Hassan, Ahmed Ali, Salama A S Shany, Magdy F El-Kady
In this study, commercial broilers were experimentally infected with single (classical IBV, variant IBV or AIV-H9N2) or mixed AIV-H9N2 with classical, variant or vaccine strains of IBV. Birds were monitored for clinical and pathological outcomes and virus shedding for 10days post infection (DPI). Clinical signs were limited to the respiratory tract in all challenged groups and varied from mild to moderate mouth breathing to severe respiratory signs with snorting sound and extended head. Mortalities were only recorded in mixed AIV-H9N2/variant IBV challenge group...
June 30, 2017: Research in Veterinary Science
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