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Coffee derivatives

Run Yan, Jie Zhang, Hye-Jin Park, Eun S Park, Stephanie Oh, Haiyan Zheng, Eunsung Junn, Michael Voronkov, Jeffry B Stock, M Maral Mouradian
Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). The catalytic subunit of the specific phosphatase, protein phosphatase 2A (PP2A) that dephosphorylates α-synuclein, is hypomethylated in these brains, thereby impeding the assembly of the active trimeric holoenzyme and reducing phosphatase activity. This phosphatase deficiency contributes to the accumulation of hyperphosphorylated α-synuclein, which tends to fibrillize more than unmodified α-synuclein...
December 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
Rosimeire Resende Dos Santos, Lívia Dias Vidotti Leal, Zenilda de Lourdes Cardeal, Helvécio Costa Menezes
Polycyclic aromatic hydrocarbons (PAHs) are food contaminants; besides, their oxygenated (oxy-PAHs) and nitrated (nitro-PAHs) derivatives have also been detected in some foods. This is worrying because these derivatives may be more toxic than PAHs. This study presents a new method for the determination of PAHs and their oxygenated and nitrated derivatives in coffee brew. The analytes were extracted by cold fiber solid phase microextraction (CF-SPME) with analysis by gas chromatography/mass spectrometry. The developed method presented good precision with intra-assay and inter-assay, ranged from 4...
November 26, 2018: Journal of Chromatography. A
Hervé Etienne, David Breton, Jean-Christophe Breitler, Benoît Bertrand, Eveline Déchamp, Rayan Awada, Pierre Marraccini, Sophie Léran, Edgardo Alpizar, Claudine Campa, Philippe Courtel, Frédéric Georget, Jean-Paul Ducos
Since the 1990s, somatic embryogenesis (SE) has enabled the propagation of selected varieties, Arabica F1 hybrid and Robusta clones, originating from the two cultivated coffee species, Coffea arabica and Coffea canephora , respectively. This paper shows how mostly empirical research has led to successful industrial transfers launched in the 2000s in Latin America, Africa, and Asia. Coffee SE can be considered as a model for other woody perennial crops for the following reasons: (i) a high biological efficiency has been demonstrated for propagated varieties at all developmental stages, and (ii) somaclonal variation is understood and mastered thanks to intensive research combining molecular markers and field observations...
2018: Frontiers in Plant Science
Huan-Cheng Chang, Chuan-Fa Hsieh, Yi-Chin Lin, Disline Manli Tantoh, Pei-Chieh Ko, Ya-Yu Kung, Mei-Chi Wang, Shu-Yi Hsu, Yi-Ching Liaw, Yung-Po Liaw
BACKGROUND: Results from studies investigating the association between coffee consumption and osteoporosis or bone mineral density (BMD) have been inconsistent. This longitudinal study was performed to assess the effect of coffee drinking on bone health of Taiwanese adults. METHODS: Data were retrieved from the Li-Shin (Landseed) Hospital in Taoyuan City. In 2006, 6152 participants completed a questionnaire on coffee drinking and other lifestyle factors. In 2014, 5077 of them were followed up...
November 20, 2018: BMC Public Health
Renata Zawirska-Wojtasiak, Paulina Piechowska, Elżbieta Wojtowicz, Krzysztof Przygoński, Sylwia Mildner-Szkudlarz
Epidemiological studies have suggested that coffee consumption is negatively correlated with the incidence of Parkinson's disease. Coffee contains relatively high levels of β-carbolines, which have been ascribed neuroactive effects in humans however the positive or negative effect has not been confirmed yet. Two ingredients with applications as coffee substitutes-chicory, which is traditionally used in this way, and artichoke-were considered in this study both from the neuroactive point of view but also in relation to the other bioactive compounds that result from their thermal processing...
2018: PloS One
Quynh Anh Nguyen, Eun Jin Cho, Dae-Seok Lee, Hyeun-Jong Bae
Spent coffee grounds (SCG) or coffee residue wastes (CRW) provide excellent raw material for mannose and bioethanol production. In this study, SCG were used to produce valuable biosugars, including oligosaccharides (OSs), manno-oligosaccharides (MOSs), mannose, and bioethanol. SCG were subjected to delignification and defatting, producing SCG-derived polysaccharides. Two-stage enzymatic hydrolysis (short- and long-term) was performed to produce short-chain manno-oligosaccharides (MOSs) and monosaccharides (MSs), respectively...
October 6, 2018: Bioresource Technology
Ling-Wei Chen, Roisin Fitzgerald, Celine M Murrin, John Mehegan, Cecily C Kelleher, Catherine M Phillips
Background: Maternal caffeine intake is associated with adverse birth outcomes, but in most studies the primary caffeine source is coffee; the influence of tea caffeine remains unclear. Objective: The aim of the study was to examine the association between maternal caffeine intake and birth outcomes in a population with tea as the predominant caffeine source. Design: Data from 941 Irish mother-child pairs of the Lifeways Cross Generation Cohort Study were examined...
October 19, 2018: American Journal of Clinical Nutrition
Antonia Costa-Bauza, Felix Grases, Paula Calvó, Adrian Rodriguez, Rafael M Prieto
The purpose of this study was to determine the effects of consumption of different cocoa-derived products on uric acid crystallization in urine of 20 healthy volunteers. Participants were requested to select the specific diet that they wished to follow during the 12 h prior to collection of urine. The only restriction was that the diet could not include any product with cocoa, coffee, or caffeine. On the first day, each volunteer followed their selected diet, and an overnight 12 h urine sample was collected as the baseline urine...
October 16, 2018: Nutrients
Anja Rahn, Chahan Yeretzian
This study examined the influence of consumer behavior on furan, 2-methylfuran, 3-methylfuran, 2,5-dimethylfuran and 2,3-dimethylfuran exposure in coffee. Coffees brewed using a filter, fully automatic, capsule machine or reconstituted instant coffee were found to have a significant different cup concentrations of furan derivatives. Coffee brewed with the fully automatic machine contained the highest furan and furan derivative concentrations (99.05 µg/L furan, 263.91 µg/L 2-methylfuran, 13.15 µg/L 3-methylfuran and 8...
January 30, 2019: Food Chemistry
Gilberto V de Melo Pereira, Dão P de Carvalho Neto, Antonio I Magalhães Júnior, Zulma S Vásquez, Adriane B P Medeiros, Luciana P S Vandenberghe, Carlos R Soccol
The aim of this review is to describe the volatile aroma compounds of green coffee beans and evaluate sources of variation in the formation and development of coffee aroma through postharvest processing. The findings of this survey showed that the volatile constituents of green coffee beans (e.g., alcohols, aldehydes, and alkanes) have no significant influence on the final coffee aroma composition, as only a few such compounds remain in the beans after roasting. On the other hand, microbial-derived, odor-active compounds produced during removal of the fruit mucilage layer, including esters, higher alcohols, aldehydes, and ketones, can be detected in the final coffee product...
January 30, 2019: Food Chemistry
Nivedita Singh, Ashwinee Kumar Shreshtha, M S Thakur, Sanjukta Patra
Medicinal plants have been the basis for discovery of various important marketed drugs. Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline, theobromine, etc) are abode in tea, coffee, cocoa, chocolate etc. giving them popular recognition. These compounds are best known for their diverse pharmaceutical applications as cyclic nucleotide phosphodiesterase inhibition, antagonization of adenosine receptor, anti-inflammatory, anti-microbial, anti-oxidant and anti-tumor activities...
October 2018: Heliyon
Cees J M van Rijn
We show that emanating jets can be regarded as growing liquid towers, which are shaped by the twofold action of surface tension: first the emanated fluid is being accelerated back by surface tension force, herewith creating the boundary conditions to solve the shape of the liquid tower as a solution of an equation mathematically related to the hydrostatic Young-Laplace equation, known to give solutions for the shape of pending and sessile droplets, and wherein the only relevant forces are gravity g and surface tension γ...
November 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Ningjian Liang, David D Kitts
Understanding the potential effects of chlorogenic acid (CGA) isomers on the intestinal epithelium is important because coffee intake exposes consumers to the six major CGA isomers: 3-caffeoylquinic acid (3-CQA), 4-caffeoylquinic acid (4-CQA), 5-caffeoylquinic acid (5-CQA), 3,4-dicaffeoylquinic acid (3,4-diCQA), 3,5-dicaffeoylquinic acid (3,5-diCQA), and 4,5-dicaffeoylquinic acid (4,5-diCQA). The present study determined the relative effects of CGA isomers on the antioxidant status of inflamed Caco-2 intestinal cells by investigating the oxidative-stress-responsive pathway and nuclear-factor-erythroid-derived-2-like 2 (Nrf2) signaling...
October 24, 2018: Journal of Agricultural and Food Chemistry
Xiumin Chen, Kaiwen Mu, David D Kitts
Our previous study reported that different tea processing methods along with the age of coffee leaves affected antioxidant and anti-inflammatory bioactivities; however, identification of phytochemical components or associated mixtures that contribute to the anti-/pro-inflammatory activities was not determined. Herein, we report results of additional experiments designed to characterize the phytochemical composition of fractionated coffee leaf extract, derived from Japanese-style-green-tea-process-young (JGTP-Y) and black-tea-process-mature (BTP-M) leaves and related these data to anti-/pro-inflammatory activities...
January 15, 2019: Food Chemistry
Cheol Soo Yoon, Min Keun Kim, Yeon Sook Kim, Suk Keun Lee
RAW 264.7 cells and HUVECs were compared to evaluate the effects of dialyzed coffee extract (DCE) and artificial coffee (AC). Immunoprecipitation high performance liquid chromatography (IP-HPLC) showed DCE-2.5- (equivalent to 2.5 cups of coffee a day) and DCE-5-induced protein expression that was beneficial to human health, i.e., they led to significant increases in proliferation-, immunity-, cellular protection-, antioxidant signaling-, and osteogenesis-related proteins but decreases in inflammation-, NFkB signaling-, cellular apoptosis-, and oncogenic signaling-related proteins in RAW 264...
September 14, 2018: Scientific Reports
Julius Schuster, Ellen S Mitchell
In general, preparations of coffee, teas, and cocoa containing high levels of polyphenols, L-theanine and other bioactive compounds selectively enhance mood and cognition effects of caffeine. This review summarizes the bioactive components of commonly consumed natural caffeine sources (e.g. guayusa, mate and camellia teas, coffee and cocoa) and analyzes the psychopharmacology of constituent phytochemicals: methylxanthines, polyphenols, and L-theanine. Acute and chronic synergistic effects of these compounds on mood and cognition are compared and discussed...
September 10, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Praetinee Pattamayutanon, Chi-Chung Peng, Chainarong Sinpoo, Panuwan Chantawannakul
This study was carried out to assess the impact of pollen feeding from common floral sources in Thailand (e.g., tea, coffee, and bitter bush) on royal jelly (RJ) properties (i.e., protein pattern, (E)-9-hydroxydec-2-enoic acid (9-HDA), and (E)-10-hydroxy-2-decenoic acid (10-HDA) contents and antibacterial activity). The protein patterns from three different pollen were different, while RJ samples derived from bee colonies fed by different pollen, exhibited similar protein patterns. RJ samples from bee colonies fed by pollen from bitter bush and coffee possessed the higher 10-HDA levels than RJ collected from bee colonies fed by tea pollen...
August 31, 2018: Journal of Economic Entomology
Chiara Magoni, Ilaria Bruni, Lorenzo Guzzetti, Mario Dell'Agli, Enrico Sangiovanni, Stefano Piazza, Maria Elena Regonesi, Mariateresa Maldini, Roberto Spezzano, Donatella Caruso, Massimo Labra
Coffee is the second traded food commodity in the world. Beyond roasted seeds, the most part of the original fruit -and in particular pulp- is discarded as waste, with severe environmental and economic consequences in many developing countries. Our research focused on developing an eco-friendly extraction protocol of phytocomplexes from coffee pulp and evaluating their bioactivity and beneficial effects to human health as food supplements. Antioxidant activity assays (Folin-Ciocalteu and DPPH assays) were adopted to select the most effective extraction technique and results show antioxidant activity of coffee pulp extracts...
October 2018: Food Research International
Alexandra Kasabova-Angelova, Diana Tzankova, Javor Mitkov, Maya Georgieva, Virginia Tzankova, Alexander Zlatkov, Magdalena Kondeva-Burdina
Parkinson's disease (PD) is a neurodegenerative and debilitating disease that affects 1% of elderly population. Patient's motor disability results in an extreme difficulty to deal with daily activities. Conventional treatment is limited to dopamine replacement therapy, which fails to delay disease's progression and is often associated with a number of adverse reactions. Recent progress in understanding the mechanisms involved in PD has revealed new molecular targets for therapeutic approaches. Among them, caffeine and xanthine derivatives are promising drug candidates, because of the possible symptomatic benefits in PD...
August 21, 2018: Current Medicinal Chemistry
Sisse Fagt, Jeppe Matthiessen, Camilla Thyregod, Karsten Kørup, Anja Biltoft-Jensen
Breakfast is considered by many to be the most important meal of the day. This study examined the intake of nutrients and foods at breakfast among Danes and the relation to the overall dietary quality. Data were derived from the Danish National Survey on Diet and Physical Activity 2011⁻2013, a cross-sectional national food consumption study. A total of 3680 participants aged 6⁻75 years were included in the analyses of breakfast consumption. The Nutrient Rich Food Index 9.3 method was used to examine the overall dietary quality of the diet...
August 14, 2018: Nutrients
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