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Coffee derivatives

Runa B Barnung, Therese H Nøst, Stine M Ulven, Guri Skeie, Karina S Olsen
Norwegians are the second highest consumers of coffee in the world. Lately, several studies have suggested that beneficial health effects are associated with coffee consumption. By analyzing whole-blood derived, microarray based mRNA gene expression data from 958 cancer-free women from the Norwegian Women and Cancer Post-Genome Cohort, we assessed the potential associations between coffee consumption and gene expression profiles and elucidated functional interpretation. Of the 958 women included, 132 were considered low coffee consumers (<1 cup of coffee/day), 422 moderate coffee consumers (1⁻3 cups of coffee/day), and 404 were high coffee consumers (>3 cups of coffee/day)...
August 9, 2018: Nutrients
Chyara Elisa Nofianti, Intan Novita Sari, Marlina, Novialdi, Jeanne Adiwinata Pawitan
Background: We have developed a simple lipoaspirate washing method using a coffee filter to eliminate liposuction noxious material before isolating adipose tissue derived mesenchymal stem cells (AT-MSCs), and used them in clinical trials. Before administration to patients, MSCs are usually suspended in physiologic saline. However, MSCs only survive for a limited time in physiologic saline. Therefore, alternative solution that can preserve MSC survival will be beneficial. Therefore, the purpose of this study was to compare the use of physiologic saline and Dulbecco's modified Eagle's Medium (DMEM) as temporary storage solution for our AT-MSCs...
2018: Stem Cell Investigation
Andrew M Freeman, Pamela B Morris, Karen Aspry, Neil F Gordon, Neal D Barnard, Caldwell B Esselstyn, Emilio Ros, Stephen Devries, James O'Keefe, Michael Miller, Dean Ornish, Kim A Williams, Travis Batts, Robert J Ostfeld, Sheldon Litwin, Monica Aggarwal, Andrea Werner, Kathleen Allen, Beth White, Penny Kris-Etherton
The potential cardiovascular (CV) benefits of many trending foods and dietary patterns are still incompletely understood, and scientific inquiry continues to evolve. In the meantime, however, a number of controversial dietary patterns, foods, and nutrients have received significant media attention and are mired by "hype." This second review addresses some of the more recent popular foods and dietary patterns that are recommended for CV health to provide clinicians with current information for patient discussions in the clinical setting...
July 31, 2018: Journal of the American College of Cardiology
Edyta Adamska-Patruno, Katarzyna Billing-Marczak, Marek Orlowski, Maria Gorska, Marcin Krotkiewski, Adam Kretowski
This study investigated the efficacy of a plant-derived dietary supplement with respect to decreasing postprandial glucose and insulin peaks after the intake of real-world meals. Two randomized, double-blind, placebo-controlled, cross-over experiments were conducted on healthy subjects who received a supplement containing extracts of white mulberry, white bean, and green coffee or one containing the three extracts with added fibre before consuming high-GI/GL (glycaemic index/glycaemic load) meals. In study one, 32 subjects received an investigational product/placebo before a standardized meal at two visits...
July 25, 2018: Nutrients
Junko Kawahara, Yoshitaka Imaizumi, Keisuke Kuroda, Yasunobu Aoki, Noriyuki Suzuki
Acrylamide is a probable human carcinogen and known human neurotoxin. This study estimated hypothetical long-term dietary exposure to acrylamide of the Japanese people using probabilistic and deterministic approaches by combining the concentration of acrylamide in foods with the amount and frequency of food consumption in the population. Data included acrylamide concentrations in more than 2400 individual food samples from a national survey and the literature from 2004 to 2013. Food consumption amounts were derived from the data of 24,293 Japanese citizens aged 1 year and older in the 2012 National Health and Nutrition Survey...
August 7, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Megan Jarman, Nonsikelelo Mathe, Fatemeh Ramazani, Mohammadreza Pakseresht, Paula J Robson, Steven T Johnson, Rhonda C Bell
Few studies have explored pre-pregnancy diet and its relationship with pregnancy outcomes. The objectives of this study were to: (1) derive pre-pregnancy dietary patterns for women enrolled in a prospective cohort in the province of Alberta, Canada; (2) describe associations between dietary patterns and socio-demographic characteristics; and (3) describe associations between dietary patterns and pregnancy complications. Upon enrolment into the Alberta Pregnancy Outcomes and Nutrition (APrON) study (median age of gestation, 17 weeks), women ( n = 1545) completed a validated 142-item food frequency questionnaire recording food and beverages consumed "in the 12 months prior to pregnancy"...
July 17, 2018: Nutrients
Joseph A Rothwell, Francisco Madrid-Gambin, Mar Garcia-Aloy, Cristina Andres-Lacueva, Caomhan Logue, Alison M Gallagher, Carina Mack, Sabine E Kulling, Qian Gao, Giulia Praticò, Lars O Dragsted, Augustin Scalbert
Non-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases. A wide variety of beverage constituents are absorbed in the gut, found in the systemic circulation and excreted in urine. They may be used as compliance markers in intervention studies or as biomarkers of intake to improve measurements of beverage consumption in cohort studies and reveal new associations with disease outcomes that may have been overlooked when using dietary questionnaires...
2018: Genes & Nutrition
Mirko De Rosso, Silvia Colomban, Riccardo Flamini, Luciano Navarini
Chlorogenic acids are relevant coffee quality markers, taste and aroma precursors as well as important bioactive compounds. A number of mono-acyl, di-acyl and tri-acyl quinic acid isomers were found in green coffee beans, being mono-caffeoyl, mono-feruloyl, mono-p-coumaroyl and di-caffeoylquinic acid isomers considered as quantitatively major compounds. Roasting process increases the chemical complexity of coffee by inducing the formation of a number of lactones (quinides), shikimates and other chlorogenic acids derivatives...
July 4, 2018: Journal of Mass Spectrometry: JMS
Hye-Young Seo, Mi-Kyung Kim, So-Hee Lee, Jae Seok Hwang, Keun-Gyu Park, Byoung Kuk Jang
Gut derived bacterial endotoxins, such as lipopolysaccharide (LPS), are involved in one of the important mechanisms that lead to inflammation associated with various liver diseases, including nonalcoholic fatty liver disease and alcoholic liver disease. Kahweol is a coffee-specific diterpene present in coffee bean and exhibits anti-angiogenic and anti-inflammatory activities. However, to date, the effect of kahweol on liver inflammation remains unknown. In this study, we examined whether kahweol exhibits a protective effect by inhibiting liver inflammation in primary Kupffer cells and primary hepatocytes cultures as well as their co-cultures...
July 4, 2018: Nutrients
Valéria Troncoso Baltar, Diana Barbosa Cunha, Roberta de Oliveira Santos, Dirce Maria Marchioni, Rosely Sichieri
The objective was to investigate the relationships between body mass index (BMI), skipping breakfast, and breakfast patterns in Brazilian adults. We analyzed data of 21,003 individuals aged between 20 to 59 from the Brazilian National Dietary Survey 2008-2009. Breakfast was defined as the eating occasion between 5 and 10a.m. with the highest usual food consumption (exceeding 50Kcal/209.2kJ). Dietary patterns were derived by the factor analysis of 18 food groups (usual intake). Controlling for confounders linear regressions of BMI were used to verify the associations considering the survey design...
June 25, 2018: Cadernos de Saúde Pública
Martin Cheek, Maria G Alvarez-Aguirre, Aurélie Grall, Bonaventure Sonké, Melanie-Jayne R Howes, Isabel Larridon
Two new coffee relatives (tribe Coffeeae, Rubiaceae), discovered during botanical expeditions to Cameroon, are examined for generic placement, and the placement of three previously known species (Argocoffeopsis fosimondi, A. spathulata and Calycosiphonia pentamera) is reinvestigated using plastid sequence (accD-psa1, rpl16, trnL-F) and morphological data. Seed biochemistry of the new species and pollen micromorphology (only one of the two species) are also studied. Based on the plastid sequence data, the new taxa are nested in a well-supported monophyletic group that includes Argocoffeopsis and Calycosiphonia...
2018: PloS One
Hye-Bin Kim, Seon-Hee Kim, Eun-Ki Jeon, Do-Hyung Kim, Daniel C W Tsang, Daniel S Alessi, Eilhann E Kwon, Kitae Baek
To date, studies on the mobility of arsenic (As) in soil amended with biochar have primarily relied on broad empirical observations, resulting in a gap between the behavior of As in amended soil and the chemical mechanisms controlling that behavior. This study focuses on the influence of abiotic factors in As mobility in As-contaminated soils amended with biochar. In order to understand the leaching of DOC and phosphate across a range of biomass feedstock and pyrolysis temperature, rice straw and granular sludge from an anaerobic digester were pyrolyzed at 300, 550, and 700 °C, and subjected to leaching studies by mixing air dried soil with 10 wt% of biochar at a soil: water ratio of 1:1(w/v)...
September 15, 2018: Science of the Total Environment
Fai-Chu Wong, Tsun-Thai Chai, Jianbo Xiao
In our diets, many of the consumed foods are subjected to various forms of heating and thermal processing. Besides enhancing the taste, texture, and aroma of the foods, heating helps to sterilize and facilitate food storage. On the other hand, heating and thermal processing are frequently reported during the preparation of various traditional herbal medicines. In this review, we intend to highlight works by various research groups which reported on changes in phytochemicals and bioactivities, following thermal processing of selected plant-derived foods and herbal medicines...
May 22, 2018: Critical Reviews in Food Science and Nutrition
Øivind Midttun, Arve Ulvik, Ottar Nygård, Per M Ueland
Background: Coffee is a widely consumed beverage, and studies suggest that drinking coffee has beneficial health effects. The phytohormone trigonelline is present in large amounts in coffee beans, and circulating concentrations of trigonelline have been shown to be positively related to dietary intake of coffee and to increase significantly after the consumption of a bolus dose of coffee. Objective: We cross-sectionally investigated the utility of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting...
June 1, 2018: American Journal of Clinical Nutrition
Ang Zhou, Amy E Taylor, Ville Karhunen, Yiqiang Zhan, Suvi P Rovio, Jari Lahti, Per Sjögren, Liisa Byberg, Donald M Lyall, Juha Auvinen, Terho Lehtimäki, Mika Kähönen, Nina Hutri-Kähönen, Mia Maria Perälä, Karl Michaëlsson, Anubha Mahajan, Lars Lind, Chris Power, Johan G Eriksson, Olli T Raitakari, Sara Hägg, Nancy L Pedersen, Juha Veijola, Marjo-Riitta Järvelin, Marcus R Munafò, Erik Ingelsson, David J Llewellyn, Elina Hyppönen
Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests...
May 14, 2018: Scientific Reports
Ecem Evrim Çelik, Jose Manuel Amigo Rubio, Mogens Larsen Andersen, Vural Gökmen
The interactions of coffee and bread crust melanoidins with hydroxycinnamic and hydroxybenzoic acids (HCA/HBA) containing different numbers of -OH and -OCH₃ groups localized at different positions on the aromatic ring were investigated. By doing so, mechanism of the interactions was intended to be explained with a structural approach. Experimental studies were carried out in DPPH radical medium. Chemometric methods were used for experimental design and multivariate data analysis. Area under the curve (AUC) values calculated from the plots of time versus inhibition (%) for coffee and bread crust melanoidins and HCA/HBA derivatives were ranged between 6532 ± 97-19,106 ± 85, 3997 ± 102-7565 ± 159 and - 1678 ± 81-22,486 ± 119, respectively...
June 2018: Food Research International
Jonas Christoffersson, Florian Meier, Henning Kempf, Kristin Schwanke, Michelle Coffee, Mario Beilmann, Robert Zweigerdt, Carl-Fredrik Mandenius
Three-dimensional (3D) models with cells arranged in clusters or spheroids have emerged as valuable tools to improve physiological relevance in drug screening. One of the challenges with cells cultured in 3D, especially for high-throughput applications, is to quickly and non-invasively assess the cellular state in vitro. In this article, we show that the number of cells growing out from human induced pluripotent stem cell (hiPSC)-derived cardiac spheroids can be quantified to serve as an indicator of a drug&rsquo;s effect on spheroids captured in a microfluidic device...
May 4, 2018: Bioengineering
Nina Steinemann, Leticia Grize, Marco Pons, Thomas Rothe, Daiana Stolz, Alexander Turk, Christian Schindler, Christine Brombach, Nicole Probst-Hensch
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is not restricted to smokers. Dietary habits may contribute to the disease occurrence. Epidemiological studies point to a protective effect of fruit and vegetable intake against COPD. OBJECTIVE: To investigate the associations between dietary patterns and parameters of lung function related to COPD in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). METHODS: Data were included from the second follow-up assessment of the SAPALDIA cohort in 2010-2011 using a food frequency questionnaire...
2018: Respiration; International Review of Thoracic Diseases
Alexandros Priftis, Dimitra Mitsiou, Maria Halabalaki, Georgia Ntasi, Dimitrios Stagos, Leandros A Skaltsounis, Demetrios Kouretas
Coffee is a highly consumed beverage throughout the world. Its popularity derives from its organoleptic properties that are a result of the roasting process. Roasting greatly alters a coffee bean's composition and possibly its bioactivity. In the current study, green as well as roasted extracts from both Coffea arabica (Brazil and Decaf) and Coffea canephora (Robusta) species were tested for their antimutagenic activity using the Ames test. In addition, a compositional analysis was conducted to identify the main components, mainly Chlorogenic acid isomers (CGA) and derivatives present in the extracts using UHPLC-ESI(±) and HRMS/MS methods According to the results, all extracts exhibited strong antimutagenic activity against the oxidizing factor tert-Butyl hydroperoxide, a Reactive Oxygen Species-producing compound...
May 2018: Mutation Research
Shun Katada, Takuya Watanabe, Tomohito Mizuno, Shinichi Kobayashi, Masao Takeshita, Noriko Osaki, Shigeru Kobayashi, Yoshihisa Katsuragi
Chlorogenic acids (CGAs) reduce blood pressure and body fat, and enhance fat metabolism. In roasted coffee, CGAs exist together with the oxidant component hydroxyhydroquinone (HHQ). HHQ counteracts the antihypertensive effects of CGA, but its effects on CGA-induced fat oxidation (FOX) are unknown. Here we assessed the effects of CGA-enriched and HHQ-reduced coffee on FOX. Fifteen healthy male volunteers (age: 38 &plusmn; 8 years (mean &plusmn; SD); BMI: 22.4 &plusmn; 1.5 kg/m²) participated in this crossover study...
April 23, 2018: Nutrients
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