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atrial fibrillation inflammation

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https://www.readbyqxmd.com/read/30081810/-epicardial-fat-and-atrial-fibrillation-the-role-of-profibrinogenic-mediators
#1
E Z Golukhova, O I Gromova, N I Bulaeva, M G Arakelyan, L S Lifanova, M A Shlyappo, S A Alexandrova, V N Makarenko
BACKGROUND: Epicardial adipose tissue (EAT) has certain paracrine functions, which could be associated with proinflammatory and fibrotic changes in myocardium even in patients without structural heart disease but with atrial fibrillation (AF). PURPOSE: to evaluate interrelationship between clinical data, parameters of tissue Doppler imaging (TDI), EAT thickness estimated by magnetic resonance imaging (MRI), and biochemical markers of fibrosis and inflammation in patients with nonvalvular AF without concomitant ischemic heart disease (IHD)...
July 2018: Kardiologiia
https://www.readbyqxmd.com/read/30076825/dementia-and-atrial-fibrillation-pathophysiological-mechanisms-and-therapeutic-implications
#2
REVIEW
Romain Chopard, Gregory Piazza, Seth Alan Gale, Umberto Campia, Ida Ehlers Albertsen, Jisoo Kim, Samuel Z Goldhaber
Atrial fibrillation increases the risk of stroke by a factor of 4- to 5-fold, and dementia is a common consequence of stroke. However, atrial fibrillation has been associated with cognitive impairment and dementia, even in patients without prior overt stroke. Non-ischemic mechanisms include cerebral hypoperfusion, vascular inflammation, brain atrophy, genetic factors, and shared risk factors such as age or hypertension. Critical appraisal of studies evaluating the association between atrial fibrillation and dementia in stroke-free patients reveals that several suffer from methodological issues, such as not including silent stroke or anticoagulation therapy in multivariate analyses...
August 1, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/30075607/autoimmune-activation-as-a-determinant-of-atrial-fibrillation-among-turks-a-prospective-evaluation
#3
Barış Şimşek, Servet Altay, Nazmiye Özbilgin, Altan Onat
Although low-grade inflammation has been linked to the prediction of atrial fibrillation (AF), evidence from some reports suggest that autoimmune activation might potentially be a relevant mechanism. We assessed the predictive value of inflammation and other markers for the risk of incident AF.A score of age-controlled anthropometric, lipid, and nonlipid variables was compared in participants with recorded nonvalvular persistent/permanent AF (n = 110) to those of a nested cohort sample (n = 1126) of the Turkish Adult Risk Factor study...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30071583/potential-impact-of-oral-inflammations-on-cardiac-functions-and-atrial-fibrillation
#4
REVIEW
Ghazal Aarabi, Renate B Schnabel, Guido Heydecke, Udo Seedorf
Inflammation may be a risk factor for atrial fibrillation (AF). Oral infections frequently lead to chronic inflammation, such as gingivitis, periodontitis, and endodontic lesions. In this narrative review, we consider five basic pathogenic mechanisms that involve oral infections and inflammations in the pathogenesis of AF: (1) low level bacteremia by which oral bacteria enter the blood stream at inflamed sites of the oral cavity and invade the heart; (2) Systemic inflammation induced by inflammatory mediators, which are released from the sites of oral inflammation into the blood stream, affecting cardiac remodeling; (3) autoimmunity against molecular structures expressed in the heart caused by the host immune response to specific components of oral pathogens; (4) potentially arrhythmic effects mediated by activation of the autonomous nervous system triggered by oral inflammations; and (5) arrhythmic effects resulting from specific bacterial toxins that are produced by oral pathogenic bacteria...
August 1, 2018: Biomolecules
https://www.readbyqxmd.com/read/30057766/risk-factors-for-incident-heart-failure-with-preserved-or-reduced-ejection-fraction-and-valvular-heart-failure-in-a-community-based-cohort
#5
Fei Fei Gong, Michael V Jelinek, Julian M Castro, Jennifer M Coller, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Rory Wolfe, Simon Stewart, Alice J Owen, Henry Krum, Christopher M Reid, David L Prior, Duncan J Campbell
Background: The lack of effective therapies for heart failure with preserved ejection fraction (HFpEF) reflects an incomplete understanding of its pathogenesis. Design: We analysed baseline risk factors for incident HFpEF, heart failure with reduced ejection fraction (HFrEF) and valvular heart failure (VHF) in a community-based cohort. Methods: We recruited 2101 men and 1746 women ≥60 years of age with hypertension, diabetes, ischaemic heart disease (IHD), abnormal heart rhythm, cerebrovascular disease or renal impairment...
2018: Open Heart
https://www.readbyqxmd.com/read/30022775/association-between-aplastic-anemia-and-atrial-fibrillation-is-inflammation-the-only-underlying-mechanism-reply
#6
Wei-Syun Hu, Fung-Chang Sung, Cheng-Li Lin
No abstract text is available yet for this article.
July 18, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/30022774/association-between-aplastic-anemia-and-atrial-fibrillation-is-inflammation-the-only-underlying-mechanism
#7
Yusuf Ziya Şener, Metin Okşul, Cem Çöteli
No abstract text is available yet for this article.
July 18, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/30016501/arrhythmogenic-mechanisms-of-obstructive-sleep-apnoea-in-heart-failure-patients
#8
Karan R Chadda, Ibrahim T Fazmin, Shiraz Ahmad, Haseeb Valli, Charlotte E Edling, Christopher L-H Huang, Kamalan Jeevaratnam
Heart failure (HF) affects 23 million people worldwide and results in 300,000 annual deaths. It is associated with many comorbidities, such as obstructive sleep apnoea (OSA), and risk factors for both conditions overlap. 11% of HF patients have OSA and 7.7% of OSA patients have left ventricular ejection fraction <50% with arrhythmias being a significant comorbidity in HF and OSA patients. 40% of HF patients develop atrial fibrillation (AF) and 30-50% of deaths from cardiac causes in HF patients are from sudden cardiac death...
July 16, 2018: Sleep
https://www.readbyqxmd.com/read/30007327/atrial-arrhythmias-in-takotsubo-cardiomyopathy-incidence-predictive-factors-and-prognosis
#9
Laurence Jesel, Charlotte Berthon, Nathan Messas, Han S Lim, Mélanie Girardey, Halim Marzak, Benjamin Marchandot, Annie Trinh, Patrick Ohlmann, Olivier Morel
Aims: Takotsubo cardiomyopathy (TTC) is a stress-related transient cardiomyopathy. It is unclear whether TTC is associated with poorer prognosis when atrial arrhythmia (AA), atrial fibrillation or flutter, occurs. The purpose of this study was to assess the incidence of AA in patients with TTC, predictive factors of AA, and its association with mortality. Methods and results: We studied 214 consecutive cases of TTC over 8 years. The study cohort was divided into two groups-those with newly diagnosed AA (AA-group) and those without (non-AA group)...
July 10, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/30007116/longitudinal-increase-in-blood-biomarkers-of-inflammation-or-cardiovascular-disease-and-the-incidence-of-venous-thromboembolism
#10
Aaron R Folsom, Pamela L Lutsey, Susan R Heckbert, Kripa Poudel, Saonli Basu, Ron C Hoogeveen, Mary Cushman, Christie M Ballantyne
BACKGROUND: We previously showed that participants in the population-based Atherosclerosis Risk in Communities (ARIC) cohort with elevated blood biomarkers of inflammation or cardiac disease were at increased risk of venous thromboembolism (VTE). OBJECTIVE: We hypothesized now that ARIC participants with larger 6-year increases in three biomarkers - C-reactive protein (CRP), N-terminal pro B-type natriuretic peptide (NT-proBNP), and troponin T - also would have increased subsequent risk of VTE...
July 14, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29988279/soluble-urokinase-plasminogen-activator-receptor-supar-as-a-predictor-of-incident-atrial-fibrillation
#11
Oscar Westin, Line Jee Hartmann Rasmussen, Ove Andersen, Eric Buch, Jesper Eugen- Olsen, Jens Friberg
Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker of chronic low-grade inflammation and a potent predictor of cardiovascular events. We hypothesized that plasma suPAR levels would predict new-onset atrial fibrillation (AF) in a large cohort of con-secutively admitted acute medical patients during long-term follow-up. In 14,764 acutely ad-mitted patients without prior or current AF, median suPAR measured upon admission was 2.7 ng/ml (interquartile range (IQR) 1.9-4.0). During a median follow-up of 392 days (IQR 218-577), 349 patients (2...
April 2018: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29983108/-novel-mechanisms-in-the-initiation-and-maintenance-of-atrial-fibrillation-tailored-individual-treatment
#12
Szilvia Kugler, Gábor Duray, István Préda
Atrial fibrillation affects approximately three percent of the adults. Ablation strategies targeting the isolation of the pulmonary veins are the up-to-date cornerstones for atrial fibrillation ablations. However, a one-year success rate of repeated interventions is not more than 70%. Long-term efficacy of catheter ablation is presumably limited by electrical and structural remodeling of the atria, which results in a progressive increase in the duration of atrial fibrillation to become sustained. The potential pathophysiological importance of the epicardial adipose tissue, atrial fibrosis, autonomic nervous system and arrhythmogenic foci are documented by several studies...
July 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29959347/the-relationship-of-early-recurrence-of-atrial-fibrillation-and-the-3-month-integrity-of-the-ablation-lesion-set
#13
Nebojša Mujović, Milan Marinković, Nebojša Marković, Vera Vučićević, Gregory Y H Lip, T Jared Bunch, Tatjana S Potpara
Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one consecutive AF patients who underwent a pulmonary vein isolation (PVI), roof line (RL) and mitral isthmus line (MIL) CA were enrolled. At 3 months all patients underwent invasive assessment of the lesion set integrity irrespective of ERAF...
June 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29956554/left-atrial-thrombus-resolution-in-non-valvular-atrial-fibrillation-or-flutter-biomarker-substudy-results-from-a-prospective-study-with-rivaroxaban-x-tra
#14
Kazuo Miyazawa, Daniele Pastori, Christoph Hammerstingl, Riccardo Cappato, Isabelle Ling Meng, Frank Kramer, Ariel Cohen, Anke Schulz, Martin van Eickels, Gregory Y H Lip, Francisco Marin
BACKGROUND: Non-vitamin K antagonist oral anticoagulants including rivaroxaban are widely used for stroke prevention in patients with atrial fibrillation (AF). We investigated the relationship between plasma biomarkers (indicative of thrombogenesis, fibrinolysis and inflammation) and left atrial thrombus resolution after rivaroxaban treatment. METHODS: This was an ancillary analysis of the X-TRA study, which was a prospective interventional study evaluating the use of rivaroxaban for left atrial/left atrial appendage (LA/LAA) thrombus resolution in AF patients...
June 29, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29951144/-il-10-592a-c-gene-variant-a-predictor-of-postoperative-atrial-fibrillation-in-the-north-indian-population
#15
Surabhi Yadav, Salman Akhtar, Surendra K Agarwal, Gauranga Majumdar, Suman Vimal, Mala Sharma
Background: There is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF) in different ethnicities across the globe. AF increases the risk of stroke and heart failure. Despite various researches on IL-10 response, there is limited clinical evidence present, which demonstrate a role of these immunity regulators in AF. Therefore, this study was designed to decipher the role of IL-10(-592A/C) polymorphism in the development of postoperative AF (post-OP AF)...
June 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29936044/increase-in-white-blood-cell-count-is-associated-with-the-development-of-atrial-fibrillation-after-an-acute-coronary-syndrome
#16
Hoang V Tran, Nathaniel A Erskine, Hoa L Nguyen, David D McManus, Hamza H Awad, Catarina I Kiefe, Robert J Goldberg
BACKGROUND: Evidence linking an elevated white blood cell count (WBCC), a marker of inflammation, to the development of atrial fibrillation (AF) after an acute coronary syndrome (ACS) is limited. We examined the association between WBCC at hospital admission, and changes in WBCC during hospitalization, with the development of new-onset AF during hospitalization for an ACS. METHODS: Development of AF was based on typical ECG changes in a systematic review of hospital medical records...
June 5, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29933716/high-sensitivity-troponin-i-in-persistent-atrial-fibrillation-relation-to-nt-probnp-and-markers-of-inflammation-and-haemostasis
#17
Anja Wiedswang Horjen, Sara Reinvik Ulimoen, Jon Norseth, Jesper Hastrup Svendsen, Pål Smith, Harald Arnesen, Ingebjørg Seljeflot, Arnljot Tveit
PURPOSE: As cardiac troponins emerge as prognostic markers in atrial fibrillation (AF), it is important to identify mechanisms initiating and perpetuating cardiac troponin release, including its relations to other circulating biomarkers, in AF populations. We studied associations between high-sensitivity troponin I (hs-TnI) and markers representing myocardial wall tension, inflammation and haemostasis in persistent AF. METHODS: In a double blind, placebo-controlled study, 171 patients referred for electrical cardioversion for persistent AF were randomised to receive candesartan or placebo for 3-6 weeks before and 6 months after cardioversion...
June 22, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29929399/the-association-of-non-alcoholic-fatty-liver-disease-and-atrial-fibrillation-a-review
#18
Aki Juhani Käräjämäki, Janne Hukkanen, Olavi Ukkola
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes an enormous burden to human health and health-care systems all over the world. A great proportion of this burden results from increased risk of cardiovascular diseases. Atrial fibrillation (AF) is the most common chronic heart arrhythmia globally and it increases the risk of embolic stroke and heart failure. Recent studies have explored the association between NAFLD and AF with somewhat conflicting results. However, ultrasound-verified prospective studies concur that NAFLD is associated with the incidence of AF...
July 24, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29921647/mechanisms-and-drug-development-in-atrial-fibrillation
#19
REVIEW
David Calvo, David Filgueiras-Rama, José Jalife
Atrial fibrillation is a highly prevalent cardiac arrhythmia and the most important cause of embolic stroke. Although genetic studies have identified an increasing assembly of AF-related genes, the impact of these genetic discoveries is yet to be realized. In addition, despite more than a century of research and speculation, the molecular and cellular mechanisms underlying AF have not been established, and therapy for AF, particularly persistent AF, remains suboptimal. Current antiarrhythmic drugs are associated with a significant rate of adverse events, particularly proarrhythmia, which may explain why many highly symptomatic AF patients are not receiving any rhythm control therapy...
July 2018: Pharmacological Reviews
https://www.readbyqxmd.com/read/29903685/periodontal-disease-systemic-inflammation-and-the-risk-of-cardiovascular-disease
#20
REVIEW
Edgar Francisco Carrizales-Sepúlveda, Alejandro Ordaz-Farías, Raymundo Vera-Pineda, Ramiro Flores-Ramírez
Periodontal and cardiovascular disease are both major health issues. Poor oral health has long been associated with the development of systemic diseases, with the typical example being the risk of endocarditis posterior to dental procedures. Through the years, the association of periodontal disease with other non-infectious systemic diseases has been brought to attention. One of the most interesting associations is the one that exists with the development of cardiovascular disease. Many studies, including systematic reviews and meta-analyses, suggest an important association between periodontal disease and ischaemic heart disease, cerebrovascular disease, heart failure, atrial fibrillation and peripheral artery disease...
June 2, 2018: Heart, Lung & Circulation
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