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atrial fibrillation inflammation

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https://www.readbyqxmd.com/read/30312930/the-prognostic-value-of-interleukin-6-in-multiple-chronic-diseases-and-all-cause-death-the-multi-ethnic-study-of-atherosclerosis-mesa
#1
Miguel Cainzos-Achirica, Cristina Enjuanes, Philip Greenland, John W McEvoy, Mary Cushman, Zeina Dardari, Khurram Nasir, Matthew J Budoff, Mouaz H Al-Mallah, Joseph Yeboah, Michael D Miedema, Roger S Blumenthal, Josep Comin-Colet, Michael J Blaha
BACKGROUND AND AIMS: We aimed to evaluate the associations and prognostic value of interleukin-6 (IL6) for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF), and other chronic diseases in a large, multi-ethnic, contemporary population. METHODS: We included 6617 participants from the Multi-Ethnic Study of Atherosclerosis (5640 non-users, 977 users of statins at baseline). Main outcomes were hard ASCVD events and HF; secondary outcomes included all-cause death, atrial fibrillation, venous thromboembolism and cancer...
October 4, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30275499/cognitive-dysfunction-in-atrial-fibrillation
#2
REVIEW
Malini Madhavan, Jonathan Graff-Radford, Jonathan P Piccini, Bernard J Gersh
Atrial fibrillation (AF) is the most common arrhythmia in adults, and its incidence and prevalence increase with age. The risk of cognitive impairment and dementia also increases with age, and both AF and cognitive impairment or dementia share important risk factors. In meta-analyses of published studies, AF is associated with a 2.4-fold and 1.4-fold increase in the risk of dementia in patients with or without a history of stroke, respectively. This association is independent of shared risk factors such as hypertension and diabetes mellitus...
October 1, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/30261069/presence-of-increased-inflammatory-infiltrates-accompanied-by-activated-dendritic-cells-in-the-left-atrium-in-rheumatic-heart-disease
#3
Mikio Shiba, Yasuo Sugano, Yoshihiko Ikeda, Hideshi Okada, Toshiyuki Nagai, Hatsue Ishibashi-Ueda, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
AIMS: Left atrial (LA) structural remodelling develops in rheumatic heart disease (RHD) according to the disease severity of the mitral valve and the presence of atrial fibrillation. Sustained active inflammation has been previously reported in the LA of patients with RHD, suggesting a direct role of cell-mediated immunity in the pathogenesis of LA remodelling. Dendritic cells (DCs) have a major antigen-presenting role, and are known as crucial modulators of innate and adaptive immunity...
2018: PloS One
https://www.readbyqxmd.com/read/30245816/opposite-relations-of-epicardial-adipose-tissue-to-left-atrial-size-in-paroxysmal-and-permanent-atrial-fibrillation
#4
Stavroula N Psychari, Dionysios Tsoukalas, Dimitrios Varvarousis, Anastasios Papaspyropoulos, Eleni Gkika, Athanasios Kotsakis, Ioannis A Paraskevaidis, Efstathios K Iliodromitis
Objectives: Atrial fibrillation has been associated with obesity in epidemiological studies. Epicardial adipose tissue is an ectopic fat depot in the proximity of atria, with endocrine and inflammatory properties that is implicated in the pathophysiology of atrial fibrillation. Inflammation also has a role in atrial arrhythmogenesis. The aim of this study was to investigate the potential relations of epicardial adipose tissue to left atrial size and to adiponectin and the pro-inflammatory mediators, high-sensitivity C-reactive protein, and interleukin-6 in paroxysmal and permanent atrial fibrillation...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/30239031/association-of-serum-adropin-with-the-presence-of-atrial-fibrillation-and-atrial-remodeling
#5
Bin Wang, Yusheng Xue, Fujun Shang, Sifeng Ni, Xiongtao Liu, Boyuan Fan, Haichang Wang
OBJECTIVE: Adropin, a newly identified regulatory protein encoded by Enho gene, suppressed tumor necrosis factor α-induced THP1 monocyte adhesion to human umbilical vein endothelial cells. In addition, inflammation is demonstrated to be involved in the mechanism of atrial fibrillation (AF). Atrial remodeling is correlated with the persistence and progression of AF. Adropin is hypothesized to correlated with AF and atrial remodeling. This study aims to determine the correlation of serum adropin and the presence of AF and remodeling...
September 21, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/30238135/resveratrol-an-effective-pharmacological-agent-to-prevent-inflammation-induced-atrial-fibrillation
#6
EDITORIAL
Henry Sutanto, Dobromir Dobrev, Jordi Heijman
No abstract text is available yet for this article.
November 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/30234900/prognostic-significance-of-red-cell-distribution-width-and-its-relation-to-increased-pulmonary-pressure-and-inflammation-in-acute-heart-failure
#7
Ryszard Targoński, Janusz Sadowski, Magdalena Starek-Stelmaszczyk, Radosław Targoński, Andrzej Rynkiewicz
BACKGROUND: Red cell distribution width (RDW) in acute heart failure (AHF) is accepted as a prognostic indicator with unclear pathophysiological ties. The aim of this study was to evaluate the prognostic value of RDW in AHF patients in relation to clinical and echocardiographic data. METHODS: 170 patients with AHF were retrospectively studied. All patients had laboratory testing and an echocardiogram performed within 24 h of admission to the Cardiology Department...
September 20, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/30225340/antiarrhythmic-drugs-for-atrial-fibrillation-imminent-impulses-are-emerging
#8
REVIEW
Gheorghe-Andrei Dan, Dobromir Dobrev
Rhythm and rate strategies are considered equivalent for the management of atrial fibrillation (AF). Moreover, both strategies are intended for improving symptoms and quality of life. Despite the clinical availability of several antiarrhythmic drugs (AAD) the alternatives for the patient with comorbidities are significantly fewer because of the concern regarding many adverse effects, including proarrhythmias. The impetuous development of AF ablation gave rise to a false impression that AAD are a second line therapy...
December 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/30180182/maintenance-of-low-inflammation-level-by-the-zfhx3-snp-rs2106261-minor-allele-contributes-to-reduced-atrial-fibrillation-recurrence-after-pulmonary-vein-isolation
#9
Shunsuke Tomomori, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Chikaaki Motoda, Hiroya Matsumura, Michitaka Amioka, Naoya Hironobe, Yousaku Ookubo, Shou Okamura, Hiroshi Kawazoe, Kazuaki Chayama, Yasuki Kihara
INTRODUCTION: The single nucleotide polymorphism (SNP) rs2106261 in the transcription factor gene ZFHX3 (16q22), a major regulator of inflammation, has been reported linking to atrial fibrillation (AF) by genome-wide association studies. Inflammation is known to be a strong predictor of atrial fibrillation recurrence after ablation, so we examined the association of the ZFHX3 SNP rs2106261 to inflammation marker expression and recurrence after AF ablation. METHODS: We genotyped ZFHX3 SNP rs2106261 and compared the minor (T) allele frequency between 362 paroxysmal AF (PAF) patients underwent pulmonary vein isolation (PVI) and 627 non-AF controls...
2018: PloS One
https://www.readbyqxmd.com/read/30178684/biomarkers-and-arrhythmia-recurrence-following-radiofrequency-ablation-of-atrial-fibrillation
#10
David Carballo, Stephane Noble, Sebastian Carballo, Jérome Stirnemann, Hajo Muller, Haran Burri, Nicolas Vuilleumier, Mario Talajic, Jean-Claude Tardif, Pierre-Frederic Keller, Francois Mach, Dipen Shah
Objective Atrial fibrillation (AF) is the most common cardiac arrhythmia, and radiofrequency catheter ablation of AF (RCAAF) has become increasingly popular. Cardiac stress and inflammation have been associated with AF. This study was performed to determine whether the pre- or post-AF ablation levels of high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are predictive of AF recurrence. Methods This multicenter prospective cohort study involved patients undergoing RCAAF in Switzerland and Canada...
September 4, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30167010/inflammation-and-atrial-fibrillation-a-comprehensive-review
#11
REVIEW
Panagiotis Korantzopoulos, Konstantinos P Letsas, Gary Tse, Nikolaos Fragakis, Christos A Goudis, Tong Liu
Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves electrophysiological and structural abnormalities that promote the development and perpetuation of AF. Experimental and clinical data indicate that inflammation is implicated in the pathophysiology of atrial remodeling. The mechanistic links between atrial remodeling and inflammation are complex while diverse underlying diseases and conditions may affect these pathways. Inflammatory markers have also been associated with AF development, recurrence, perpetuation, total AF burden as well as with thromboembolic complications...
August 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/30148041/atrial-fibrillation-cognitive-decline-and-dementia-an-epidemiologic-review
#12
REVIEW
Mozhu Ding, Chengxuan Qiu
Purpose of Review: Atrial fibrillation (AF) and dementia are both prevalent diseases in aging societies, which exert a great economic burden worldwide. Although a handful of epidemiologic studies have indicated that AF is independently associated with faster cognitive decline and a higher risk of dementia, there is still a lack of comprehensive understanding of the observed association. In this review, we summarize evidence from major epidemiologic studies concerning AF-related cognitive decline and dementia, the potential mechanisms underlying their association, and the cognitive benefits of treatment options...
2018: Current Epidemiology Reports
https://www.readbyqxmd.com/read/30144274/atrial-fibrillation-and-type-2-diabetes-prevalence-etiology-pathophysiology-and-effect-of-anti-diabetic-therapies
#13
REVIEW
David S H Bell, Edison Goncalves
New-onset atrial fibrillation (NAF) is increased in the type 2 diabetic patient because of the presence of the metaboli syndrome and increased sympathetic activity. This results in inflammation, endothelial dysfunction and myocardial steatosis which, in turn, lead to atrial fibrosis and dilatation. The end result is the development of structural and electrical atrial remodeling. Drugs that lower insulin resistance, particularly pioglitazone, decrease the incidence of NAF while drugs that, through hypoglycaemia, stimulate the sympathetic nervous system, insulin and secretagogues, increase the incidence of NAF...
August 24, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30140958/predictors-of-atrial-fibrillation-early-recurrence-following-cryoballoon-ablation-of-pulmonary-veins-using-statistical-assessment-and-machine-learning-algorithms
#14
Jan Budzianowski, Jarosław Hiczkiewicz, Paweł Burchardt, Konrad Pieszko, Janusz Rzeźniczak, Paweł Budzianowski, Katarzyna Korybalska
Inflammation, oxidative stress, myocardial injury biomarkers and clinical parameters (longer AF duration, left atrial enlargement, the metabolic syndrome) are factors commonly related to AF recurrence. This study aims to assess the predictive value of laboratory and clinical parameters responsible for early recurrence of atrial fibrillation (ERAF) following cryoballoon ablation (CBA) using statistical assessment and machine learning algorithms. This study group comprised 118 consecutive patients (mean age, 62...
August 23, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/30136604/strategies-to-manage-obstructive-sleep-apnea-to-decrease-the-burden-of-atrial-fibrillation
#15
Creuza M Goes, Paola P N F Falcochio, Luciano F Drager
In the last decades, consistent data derived from experimental, epidemiological, and clinical studies pointed obstructive sleep apnea (OSA), the most common sleep disordered breathing worldwide, as a potential risk factor for incidence and recurrence of atrial fibrillation (AF). Areas covered: This review article describes the impact of OSA on AF and discusses potential strategies for managing OSA in the AF scenario. Expert commentary: Untreated OSA seems to be one important predictor of AF treatment failure after chemical or electrical cardioversion as well as after a successful AF ablation...
September 3, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/30114262/high-sensitivity-c-reactive-protein-in-heart-failure-with-preserved-ejection-fraction
#16
Hilary M DuBrock, Omar F AbouEzzeddine, Margaret M Redfield
BACKGROUND: Microvascular inflammation may contribute to the pathogenesis of both heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension (PH). We investigated whether the inflammation biomarker C-reactive protein (CRP) was associated with clinical characteristics, disease severity or PH in HFpEF. METHODS: Patients in the Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart failure (RELAX) trial had baseline high-sensitivity CRP levels measured (n = 214)...
2018: PloS One
https://www.readbyqxmd.com/read/30111325/ykl-40-is-highly-expressed-in-the-epicardial-adipose-tissue-of-patients-with-atrial-fibrillation-and-associated-with-atrial-fibrosis
#17
Qing Wang, Hua Shen, Jie Min, Yang Gao, Kai Liu, Wang Xi, Jie Yang, Liang Yin, Jibin Xu, Jian Xiao, Zhinong Wang
BACKGROUND: YKL-40 (CHI3L1) is a novel biomarker for inflammation, tissue remodeling, and fibrosis, as well as cardiovascular diseases. We investigated the association between YKL-40 expression in epicardial adipose tissue (EAT) and atrial fibrosis in patients with atrial fibrillation (AF). METHODS: Blood samples, subcutaneous adipose tissue (SAT), paracardial adipose tissue (PAT), EAT, and adjacent atrial myocardium were acquired from patients receiving coronary artery bypass grafts...
August 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/30081810/-epicardial-fat-and-atrial-fibrillation-the-role-of-profibrinogenic-mediators
#18
E Z Golukhova, O I Gromova, N I Bulaeva, M G Arakelyan, L S Lifanova, M A Shlyappo, S A Alexandrova, V N Makarenko
BACKGROUND: Epicardial adipose tissue (EAT) has certain paracrine functions, which could be associated with proinflammatory and fibrotic changes in myocardium even in patients without structural heart disease but with atrial fibrillation (AF). PURPOSE: to evaluate interrelationship between clinical data, parameters of tissue Doppler imaging (TDI), EAT thickness estimated by magnetic resonance imaging (MRI), and biochemical markers of fibrosis and inflammation in patients with nonvalvular AF without concomitant ischemic heart disease (IHD)...
July 2018: Kardiologiia
https://www.readbyqxmd.com/read/30076825/dementia-and-atrial-fibrillation-pathophysiological-mechanisms-and-therapeutic-implications
#19
REVIEW
Romain Chopard, Gregory Piazza, Seth Alan Gale, Umberto Campia, Ida Ehlers Albertsen, Jisoo Kim, Samuel Z Goldhaber
Atrial fibrillation increases the risk of stroke by a factor of 4- to 5-fold, and dementia is a common consequence of stroke. However, atrial fibrillation has been associated with cognitive impairment and dementia, even in patients without prior overt stroke. Non-ischemic mechanisms include cerebral hypoperfusion, vascular inflammation, brain atrophy, genetic factors, and shared risk factors such as age or hypertension. Critical appraisal of studies evaluating the association between atrial fibrillation and dementia in stroke-free patients reveals that several suffer from methodological issues, such as not including silent stroke or anticoagulation therapy in multivariate analyses...
August 1, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/30075607/autoimmune-activation-as-a-determinant-of-atrial-fibrillation-among-turks-a-prospective-evaluation
#20
Barış Şimşek, Servet Altay, Nazmiye Özbilgin, Altan Onat
Although low-grade inflammation has been linked to the prediction of atrial fibrillation (AF), evidence from some reports suggest that autoimmune activation might potentially be a relevant mechanism. We assessed the predictive value of inflammation and other markers for the risk of incident AF.A score of age-controlled anthropometric, lipid, and nonlipid variables was compared in participants with recorded nonvalvular persistent/permanent AF (n = 110) to those of a nested cohort sample (n = 1126) of the Turkish Adult Risk Factor study...
August 2018: Medicine (Baltimore)
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