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atrial fibrillation inflammation

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https://www.readbyqxmd.com/read/30502048/relation-of-neutrophil-to-lymphocyte-ratio-to-risk-of-incident-atrial-fibrillation
#1
Anat Berkovitch, Arwa Younis, Yoni Grossman, Shlomo Segev, Shaye Kivity, Yechezkel Sidi, Roy Beinart, Ilan Goldenberg, Elad Maor
Clinical and experimental data support a critical role for inflammation in cardiovascular disease. The purpose of the current study was to examine the relation between an inflammatory marker, neutrophil-to-lymphocyte ratio (NLR), and incident atrial fibrillation (AF) in asymptomatic adults. We investigated 21,118 self-referred men and women who were annually screened in a tertiary medical center. All subjects were free of AF at baseline and had their serum NLR calculated at the first annual visit. Subjects were divided into 2 groups based on their baseline NLR: Low (<2...
November 7, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30496173/circulating-proteomic-patterns-in-af-related-left-atrial-remodeling-indicate-involvement-of-coagulation-and-complement-cascade
#2
Jelena Kornej, Petra Büttner, Elke Hammer, Beatrice Engelmann, Borislav Dinov, Philipp Sommer, Daniela Husser, Gerhard Hindricks, Uwe Völker, Andreas Bollmann
BACKGROUND: Left atrial (LA) electro-anatomical remodeling and diameter increase in atrial fibrillation (AF) indicates disease progression and is associated with poor therapeutic success. Furthermore, AF leads to a hypercoagulable state, which in turn promotes the development of a substrate for AF and disease progression in the experimental setting. The aim of this study was to identify pathways associated with LA remodeling in AF patients using untargeted proteomics approach. METHODS: Peripheral blood samples of 48 patients (62±10 years, 63% males, 59% persistent AF) undergoing AF catheter ablation were collected before ablation...
2018: PloS One
https://www.readbyqxmd.com/read/30487982/obesity-paradox-on-outcome-in-atrial-fibrillation-maintained-even-considering-the-prognostic-influence-of-biomarkers-insights-from-the-aristotle-trial
#3
Roopinder K Sandhu, Justin A Ezekowitz, Ziad Hijazi, Johan Westerbergh, Julia Aulin, John H Alexander, Christopher B Granger, Sigrun Halvorsen, Michael S Hanna, Renato D Lopes, Agneta Siegbahn, Lars Wallentin
Objective: We investigated the association between obesity and biomarkers indicating cardiac or renal dysfunction or inflammation and their interaction with obesity and outcomes. Methods: A total of 14 753 patients in the Apixaban for Reduction In STroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial provided plasma samples at randomisation to apixaban or warfarin. Median follow-up was 1.9 years. Body Mass Index (BMI) was measured at baseline and categorised as normal, 18...
2018: Open Heart
https://www.readbyqxmd.com/read/30480808/cholinergic-activity-regulates-the-secretome-of-epicardial-adipose-tissue-association-with-atrial-fibrillation
#4
Marinela Couselo-Seijas, Jose N López-Canoa, Rosa M Agra-Bermejo, Esther Díaz-Rodriguez, Angel L Fernandez, Jose M Martinez-Cereijo, Dario Durán-Muñoz, Susana B Bravo, Alba Velo, Laila González-Melchor, Xesus A Fernández-López, Jose L Martínez-Sande, Javier García-Seara, Jose R González-Juanatey, Moises Rodriguez-Mañero, Sonia Eiras
Botulinum toxin injection on epicardial fat, which inhibits acetylcholine (ACh) release, reduced the presence of atrial fibrillation (AF) in patients after heart surgery. Thus, we wanted to study the profile of the released proteins of epicardial adipose tissue (EAT) under cholinergic activity (ACh treatment) and their value as AF predictors. Biopsies, explants, or primary cultures were obtained from the EAT of 85 patients that underwent open heart surgery. The quantification of muscarinic receptors (mAChR) by real-time polymerase chain reaction or western blot showed their expression in EAT...
November 27, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30467393/indoxyl-sulphate-is-associated-with-atrial-fibrillation-recurrence-after-catheter-ablation
#5
Fumi Yamagami, Kazuko Tajiri, Kosuke Doki, Masayuki Hattori, Junya Honda, Satoshi Aita, Tomohiko Harunari, Hiro Yamasaki, Nobuyuki Murakoshi, Yukio Sekiguchi, Masato Homma, Naohiko Takahashi, Kazutaka Aonuma, Akihiko Nogami, Masaki Ieda
Renal dysfunction results in the accumulation of various uremic toxins, including indoxyl sulphate (IS), and is a major risk factor for atrial fibrillation (AF). Experimental studies have demonstrated that IS exacerbates atrial remodelling via oxidative stress, inflammation, and fibrosis. However, its clinical impact on AF-promoting cardiac remodelling has not been described. Therefore, the purpose of this study was to clarify the relationship between basal IS levels and the 1-year outcomes after catheter ablation for the treatment of AF...
November 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30409736/single-and-persistent-elevation-of-c-reactive-protein-levels-and-the-risk-of-atrial-fibrillation-in-a-general-population-the-ansan-ansung-cohort-of-the-korean-genome-and-epidemiology-study
#6
Yonggu Lee, Hwan-Cheol Park, Jeong-Hun Shin, Young-Hyo Lim, Jinho Shin, Jin-Kyu Park
BACKGROUND: Inflammation has been reported to cause atrial fibrillation (AF). However, it remains unclear whether C-reactive protein (CRP) levels predict AF. We investigated whether there was an association between serum CRP levels and the development of AF. METHODS: A total of 10,030 subjects aged between 40 and 69 years were enrolled and followed biennially over a 12-year period in the Ansan-Ansung cohort study. Serum CRP levels were measured at baseline and high-sensitivity CRP (hsCRP) levels were measured at every revisit...
October 28, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30405438/arrhythmogenic-substrates-for-atrial-fibrillation-in-obesity
#7
REVIEW
Ellen R Lubbers, Morgan V Price, Peter J Mohler
Global obesity rates have nearly tripled since 1975. This obesity rate increase is mirrored by increases in atrial fibrillation (AF) that now impacts nearly 10% of Americans over the age of 65. Numerous epidemiologic studies have linked incidence of AF and obesity and other obesity-related diseases, including hypertension and diabetes. Due to the wealth of epidemiologic data linking AF with obesity-related disease, mechanisms of AF pathogenesis in the context of obesity are an area of ongoing investigation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30399375/obesity-and-cardiovascular-disease-revisiting-an-old-relationship
#8
REVIEW
Chrysi Koliaki, Stavros Liatis, Alexander Kokkinos
A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of cardiovascular diseases (CVD) including coronary heart disease, heart failure, hypertension, stroke, atrial fibrillation and sudden cardiac death. Obesity can increase CVD morbidity and mortality directly and indirectly. Direct effects are mediated by obesity-induced structural and functional adaptations of the cardiovascular system to accommodate excess body weight, as well as by adipokine effects on inflammation and vascular homeostasis...
November 3, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/30374473/role-of-the-monocyte-to-high-density-lipoprotein-ratio-in-predicting-atrial-high-rate-episodes-detected-by-cardiac-implantable-electronic-devices
#9
Seckin Satilmis
OBJECTIVE: Technological advances have allowed cardiac implantable electronic devices (CIEDs) to detect, analyze, and store atrial high-rate episodes (AHREs), which are surrogate for the term silent atrial fibrillation (AF). The association of AHREs with adverse clinical events has been demonstrated in several recent studies, implying that morbidity and mortality can be significantly prevented by prompt recognition and intervention. Inflammation and oxidative stress are among several mechanisms that contribute to the pathogenesis of AF...
2018: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/30371151/intake-of-vitamin-k-antagonists-and-worsening-of-cardiac-and-vascular-disease-results-from-the-population-based-gutenberg-health-study
#10
Lisa Eggebrecht, Jürgen H Prochaska, Andreas Schulz, Natalie Arnold, Claus Jünger, Sebastian Göbel, Dagmar Laubert-Reh, Harald Binder, Manfred E Beutel, Nobert Pfeiffer, Stefan Blankenberg, Karl J Lackner, Henri M Spronk, Hugo Ten Cate, Thomas Münzel, Philipp S Wild
Background Preclinical data have indicated a link between use of vitamin K antagonists ( VKA ) and detrimental effects on vascular structure and function. The objective of the present study was to determine the relationship between VKA intake and different phenotypes of subclinical cardiovascular disease in the population. Methods and Results Clinical and laboratory data, as well as medical-technical examinations were assessed from 15 010 individuals aged 35 to 74 years during a highly standardized 5-hour visit at the study center of the population-based Gutenberg Health Study...
September 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30371045/atrial-fibrillation-in-the-cardiometabolic-patient
#11
Francesco De Sensi, Sarah Costantino, Ugo Limbruno, Francesco Paneni
Prevalence of obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D) is growing alarmingly, and the number of affected people continues to escalate. Such cardiometabolic states exert many deleterious effects on the heart as they are associated with adverse left ventricular (LV) remodelling and, most notably, with a marked increase in the risk of developing atrial fibrillation (AF) and subsequent stroke. Epidemiological studies clearly show a strong association between obesity and AF, with a 4-5% increase in AF risk for every unit increase in BMI...
October 29, 2018: Minerva Medica
https://www.readbyqxmd.com/read/30370780/biomarker-profiling-in-stage-5-chronic-kidney-disease-identifies-the-relationship-between-angiopoietin-2-and-atrial-fibrillation
#12
Jack Bontekoe, Justin Lee, Vinod Bansal, Mushabbar Syed, Debra Hoppensteadt, Paula Maia, Amanda Walborn, Jeffrey Liles, Eugene Brailovsky, Jawed Fareed
Atrial fibrillation (AF) is prevalent in nearly 27% of patients with stage 5 chronic kidney disease on hemodialysis (CKD5-HD), suggesting a strong association between these 2 pathologies. It is hypothesized that the relationship between these 2 diseases may be mediated by inflammation. Angiopoietin-2 (Ang-2), a pro-inflammatory biomarker of endothelial instability, inflammation, and vascular remodeling, is elevated in CKD5-HD and AF, yet has not been evaluated in patients with concomitant AF and CKD5-HD. The aim of this study is to analyze circulating levels of inflammatory and thrombotic biomarkers in patients with concomitant AF and CKD5-HD...
October 28, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/30354407/collagen-biomarkers-and-incidence-of-new-onset-of-atrial-fibrillation-in-subjects-with-no-overt-cardiovascular-disease-at-baseline
#13
Daniel A Duprez, Susan R Heckbert, Alvaro Alonso, Myron D Gross, Joachim H Ix, Jorge R Kizer, Russell P Tracy, Richard Kronmal, David R Jacobs
BACKGROUND: Atrial fibrosis is a hallmark of structural remodeling in atrial fibrillation (AF). Plasma procollagen type III N-terminal propeptide (PIIINP) reflects collagen synthesis and degradation while collagen type I carboxy-terminal telopeptide (ICTP) reflects collagen degradation. We aimed to study baseline plasma PIIINP and ICTP and their associations with incident AF in participants initially free of overt cardiovascular disease. METHODS: In a stratified sample of the Multi-Ethnic Study of Atherosclerosis, initially aged 45-84 years, 3071 participants had both PIIINP and ICTP measured at baseline...
October 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30344814/possibility-of-a-new-therapeutic-strategy-for-left-ventricular-dysfunction-in-type-2-diabetes
#14
REVIEW
Masaya Sakamoto, Daisuke Matsutani, Yosuke Kayama
Type 2 diabetes mellitus (T2DM) substantially increases the risk of cardiovascular events, including heart failure (HF), due to complications such as hypertension, obesity and dyslipidemia based on metabolic syndrome, which plays the central pathological role in HF. A reason is that T2DM causes left ventricular (LV) diastolic dysfunction beginning in the early phase of the disease, which in turn increases the risk of development of HF independently of the control of blood glucose levels, blood pressure or the presence of coronary artery diseases...
November 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/30327694/plasma-markers-of-myocardial-inflammation-at-isolated-atrial-fibrillation
#15
Svetlana Ivanovna Sazonova, Julia Nikolaevna Ilushenkova, Roman Efimovich Batalov, Anna Mihaylovna Gusakova, Julia Vladimirovna Saranchina, Julia Viktorovna Rogovskaya, Sergey Valentinovich Popov
Background: Atrial fibrillation (AF) is one of the widest spread forms of arrhythmia, which is associated with the increased mortality and thromboembolic complications. To date, the involvement of renin-angiotensin-aldosterone system and immunomediators of inflammation into the mechanisms of development and maintenance of isolated AF is not clear. Specificity of their changes with respect to the latent myocarditis at AF is not proved. Methods: In 96 patients with persistent isolated atrial fibrillation (IsAF), scheduled for radiofrequency ablation and endomyocardial biopsy (EMB), and in 20 healthy volunteers (HVT), levels of plasma tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, IL-10, fatty acid-binding protein (FABP), neopterin, C-reactive protein (CRP) were determined by ELISA, level of aldosterone and the renin activity were determined by radioimmunoassay...
October 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/30322760/clinical-features-of-post-cardiac-injury-syndrome-following-catheter-ablation-of-arrhythmias-systematic-review-and-additional-cases
#16
Wei Li, Jian Sun, Ying Yu, Zhi-Quan Wang, Peng-Pai Zhang, Kai Guo, Man-Tian Chen, Yi-Gang Li
BACKGROUND: Post cardiac injury syndrome (PCIS) is a troublesome but not uncommon complication following catheter ablation of arrhythmias. We aimed to study the clinical features of ablation-associated PCIS. METHODS: For this purpose, we conducted a computerised literature search that identified 19 published cases, and we additionally included another 2 new cases from our centres. Twenty-one cases of PCIS following ablation were analysed. RESULTS: Among the 21 cases, PCIS most commonly occurred after atrial flutter/fibrillation (AFL/AF) ablation (71...
October 7, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/30312930/the-prognostic-value-of-interleukin-6-in-multiple-chronic-diseases-and-all-cause-death-the-multi-ethnic-study-of-atherosclerosis-mesa
#17
Miguel Cainzos-Achirica, Cristina Enjuanes, Philip Greenland, John W McEvoy, Mary Cushman, Zeina Dardari, Khurram Nasir, Matthew J Budoff, Mouaz H Al-Mallah, Joseph Yeboah, Michael D Miedema, Roger S Blumenthal, Josep Comin-Colet, Michael J Blaha
BACKGROUND AND AIMS: We aimed to evaluate the associations and prognostic value of interleukin-6 (IL6) for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF), and other chronic diseases in a large, multi-ethnic, contemporary population. METHODS: We included 6617 participants from the Multi-Ethnic Study of Atherosclerosis (5640 non-users, 977 users of statins at baseline). Main outcomes were hard ASCVD events and HF; secondary outcomes included all-cause death, atrial fibrillation, venous thromboembolism and cancer...
October 4, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30275499/cognitive-dysfunction-in-atrial-fibrillation
#18
REVIEW
Malini Madhavan, Jonathan Graff-Radford, Jonathan P Piccini, Bernard J Gersh
Atrial fibrillation (AF) is the most common arrhythmia in adults, and its incidence and prevalence increase with age. The risk of cognitive impairment and dementia also increases with age, and both AF and cognitive impairment or dementia share important risk factors. In meta-analyses of published studies, AF is associated with a 2.4-fold and 1.4-fold increase in the risk of dementia in patients with or without a history of stroke, respectively. This association is independent of shared risk factors such as hypertension and diabetes mellitus...
December 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/30261069/presence-of-increased-inflammatory-infiltrates-accompanied-by-activated-dendritic-cells-in-the-left-atrium-in-rheumatic-heart-disease
#19
Mikio Shiba, Yasuo Sugano, Yoshihiko Ikeda, Hideshi Okada, Toshiyuki Nagai, Hatsue Ishibashi-Ueda, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
AIMS: Left atrial (LA) structural remodelling develops in rheumatic heart disease (RHD) according to the disease severity of the mitral valve and the presence of atrial fibrillation. Sustained active inflammation has been previously reported in the LA of patients with RHD, suggesting a direct role of cell-mediated immunity in the pathogenesis of LA remodelling. Dendritic cells (DCs) have a major antigen-presenting role, and are known as crucial modulators of innate and adaptive immunity...
2018: PloS One
https://www.readbyqxmd.com/read/30245816/opposite-relations-of-epicardial-adipose-tissue-to-left-atrial-size-in-paroxysmal-and-permanent-atrial-fibrillation
#20
Stavroula N Psychari, Dionysios Tsoukalas, Dimitrios Varvarousis, Anastasios Papaspyropoulos, Eleni Gkika, Athanasios Kotsakis, Ioannis A Paraskevaidis, Efstathios K Iliodromitis
Objectives: Atrial fibrillation has been associated with obesity in epidemiological studies. Epicardial adipose tissue is an ectopic fat depot in the proximity of atria, with endocrine and inflammatory properties that is implicated in the pathophysiology of atrial fibrillation. Inflammation also has a role in atrial arrhythmogenesis. The aim of this study was to investigate the potential relations of epicardial adipose tissue to left atrial size and to adiponectin and the pro-inflammatory mediators, high-sensitivity C-reactive protein, and interleukin-6 in paroxysmal and permanent atrial fibrillation...
2018: SAGE Open Medicine
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