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Prostate, urology

Joaquin Mateo, Karim Fizazi, Silke Gillessen, Axel Heidenreich, Raquel Perez-Lopez, Wim J G Oyen, Neal Shore, Matthew Smith, Christopher Sweeney, Bertrand Tombal, Scott A Tomlins, Johann S de Bono
CONTEXT: Patients with nonmetastatic castration-resistant prostate cancer (nmCRPC) have rising prostate-specific antigen (PSA) and castrate testosterone levels, with no radiological findings of metastatic disease on computed tomography and bone scan. Given recent drug approvals for nmCRPC, with many other therapeutics and imaging modalities being developed, management of nmCRPC is a rapidly evolving field that merits detailed investigation. OBJECTIVE: To review current nmCRPC management practices and identify opportunities for improving care of nmCRPC patients...
August 14, 2018: European Urology
Michel Wissing, Fadi Brimo, Simone Chevalier, Eleonora Scarlata, Ginette McKercher, Ana O'Flaherty, Saro Aprikian, Valérie Thibodeau, Fred Saad, Michel Carmel, Louis Lacombe, Bernard Têtu, Nadia Ekindi-Ndongo, Mathieu Latour, Dominique Trudel, Armen Aprikian
OBJECTIVES: To evaluate the 5-tier grouping for Gleason scoring (GG) of prostate cancers adopted by the International Society of Urology Pathology (ISUP) in 2014, and to propose modifications to optimize its performance. PATIENTS AND METHODS: Data were obtained from PROCURE, a prospective cohort of patients with localized prostate cancer undergoing radical prostatectomy in Québec, 2006-2013. Surgical specimens were evaluated by genitourinary pathologists using 2014 ISUP criteria...
August 16, 2018: BJU International
Dora Huang, Surena F Matin, Nathan Lawrentschuk, Morgan Roupret
Background: Lynch syndrome is an autosomal dominant disorder that predisposes individuals affected to certain malignancies. Colon and endometrial cancers are the malignancies most highly associated with Lynch syndrome. However, growing body of evidence links Lynch syndrome to urological cancers. Objective: This review aims to clarify the type of urological malignancies that fall under the Lynch-associated cancer spectrum. Methods: Using PRISMA guidelines, a systematic search between January 1990 to February 2018, was conducted using the MEDLINE database with the application of the following MESH terms: colorectal neoplasms, hereditary nonpolyposis; DNA mismatch repair; urologic neoplasms; kidney pelvis; ureteral neoplasms; urinary bladder; carcinoma, transitional cell; prostatic neoplasms; testicular neoplasms...
July 30, 2018: Bladder Cancer
Krzysztof Czaderny
INTRODUCTION: This study investigates spatial distribution and future trends in prostate cancer mortality in Poland. Since detection of prostate cancer is based on patients’ requests (not an invitation system), hypothesis of self-selection of patients was also verified MATERIAL AND METHODS: Age-period-cohort model was estimated to assess mortality trends. A spatial analysis was performed by Kulldorff’s and Moran’s tests. Structural equation model was fitted to identify factors influencing decision on participation in prostate cancer screening...
2018: Przegla̧d Epidemiologiczny
Isabel Rauscher, Matthias Eiber, Wolfgang A Weber, Jürgen E Gschwend, Thomas Horn, Tobias Maurer
Positron-emission tomography/computed tomography combining both functional and morphological information has emerged as a powerful tool in oncological imaging within the past decades. The most commonly used radiotracer in oncology visualizing metabolic information is 2-[18F]fluoro-2-deoxy-d-glucose. However, the use of 2-[18F]fluoro-2-deoxy-d-glucose in urological oncology is challenging, as it is limited by physiological excretion through the urinary system. Therefore, it is only useful when applied to specific indications in selected patients with urological malignancy; for example, for detection of residual disease in the post-chemotherapy management of patients with seminoma...
August 13, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Marco Bandini, Nicola Fossati, Alberto Briganti
PURPOSE OF REVIEW: To critically review the current literature regarding the recently published nomograms in urologic oncology and to examine the advantages and disadvantages of their application. RECENT FINDINGS: Several nomograms have been developed in the field of urologic oncology over the recent years, to improve clinical decision-making and patients counseling. In the current review, we examined 6 nomograms on prostate cancer, 9 nomograms on kidney cancer and 8 nomograms on bladder cancer that have been recently published...
August 7, 2018: Current Opinion in Urology
Anna Patrikidou, Pierre Maroun, Jean-Jacques Patard, Hervé Baumert, Laurence Albiges, Christophe Massard, Yohann Loriot, Bernard Escudier, Mario Di Palma, Julia Arfi-Rouche, Laurence Rocher, Zahira Merabet, Alberto Bossi, Karim Fizazi, Pierre Blanchard
Objectives: The initial treatment decision for newly diagnosed non-metastatic prostate cancer is complex. Multiple valid approaches exist, without a clear and absolute consensus for every clinical scenario, and therefore specialist opinions may vary. Multidisciplinary consultations focusing on shared decision-making aim to provide an apposite tool for the initial treatment decision. We have evaluated the first two years of activity of the Gustave Roussy Prostate Cancer Multidisciplinary Clinic (PCMC), dedicated to the initial decision-making for non-metastatic prostate cancer...
August 2018: Clinical and Translational Radiation Oncology
Christian Kofi Gyasi-Sarpong, Emmanuel Acheampong, Francis Agyemamg Yeboah, Kenneth Aboah, Edwin Ferguson Laing, George Amoah
Background: Lower urinary tract symptoms (LUTSs) can significantly reduce men's quality of life and may point to serious pathology of the urogenital tract. This study aimed at finding predictors of symptoms score on the International Prostate Symptom Score (IPSS) for patients with LUTS. Materials and Methods: The study was cross-sectional conducted among 225 Ghanaian men visiting the urology clinic at Komfo Anokye Teaching Hospital. Trained interviewers used the IPSS, which adds a quality of life question to the American Urology Association symptom index to determine the extent to which patients are troubled by their symptoms...
July 2018: Urology Annals
Chi-Hang Yee, Jenny S Y Yip, Nicole M Y Cheng, Cheuk-Hang Kwan, Kai-Man Li, Jeremy Y C Teoh, Peter K F Chiu, Joseph Hon-Ming Wong, Eddie S Y Chan, Chi-Kwok Chan, Simon S M Hou, Chi-Fai Ng
OBJECTIVE: It has been hypothesized that endothelial dysfunction and pelvic atherosclerosis may contribute to lower urinary tract symptoms (LUTS). We assessed the relationship between cardiovascular risk factors and LUTS severity in male patients presented to urology clinic. METHODS: It is a cross-sectional study on patients who presented between 2013 and 2015 with LUTS. A total of 1176 male patients were encountered, and 966 were included for analysis after excluding patients with urinary tract malignancy, urethral stricture, bladder stone and history of urinary tract surgery...
August 6, 2018: World Journal of Urology
A Juárez-Soto, J M Garín-Ferreira, A Rodríguez-Fernández, J L Tirado-Hospital, M T González-Serrano, J Moreno-Jiménez, R Medina-López, V Baena-González
INTRODUCTION: In castration-resistant prostate cancer (CRPC), early detection of metastases is essential for the selection of treatment, and prevention of bone complications. However detecting incipient metastases remains a challenge as the conventional radiological tests (bone scintigraphy or computerised tomography) lack sufficient sensitivity. Diagnostic imaging techniques are currently available that have greater sensitivity and specificity, but are little used due to shortfalls in the recommendations...
August 3, 2018: Actas Urologicas Españolas
Joel E Pacyna, Simon Kim, Kathleen Yost, Hillary Sedlacek, Daniel Petereit, Judith Kaur, Bruce Rapkin, Robert Grubb, Electra Paskett, George J Chang, Jeff Sloan, Ethan Basch, Brittny Major, Paul Novotny, John Taylor, Jan Buckner, J Kellogg Parsons, Michael Morris, Jon C Tilburt
BACKGROUND: Treatments for localized prostate cancer present challenging tradeoffs in the face of uncertain treatment benefits. These options are best weighed in a process of shared decision-making with the patient's healthcare team. Minority men experience disparities in prostate cancer outcomes, possibly due in part to a lack of optimal communication during treatment selection. Decision aids facilitate shared decision-making, improve knowledge of treatment options, may increase satisfaction with treatment choice, and likely facilitate long-term quality of life...
August 6, 2018: BMC Cancer
Oksana Skomarovska, Tomasz Stefura, Karolina Kainka, Łukasz Radziszewski, Anna Katarzyna Czech, Katarzyna Gronostaj, Tadeusz Hessel, Łukasz Curyło, Piotr L Chłosta
BACKGROUND AND OBJECTIVE: Urological diseases represent a significant health issue worldwide. Presented study aimed at assessing current urological knowledge and confidence in performing urological diagnostic and therapeutic procedures among medical students at Jagiellonian University Medical College in Poland and compare it on different stages of the undergraduate medical education. MATERIAL AND METHODS: We designed an anonymous survey distributed among Polish students from 1st to 6th year of medical studies, before and after clinical urology course...
2018: Folia Medica Cracoviensia
Dilip Chandrasekhar, Athira Dollychan, Bincy Mary Roy, Shinu Cholamughath, Jaffer Chalil Parambil
BACKGROUND: A prospective observational study was carried out over a period of 6 months among the inpatients and outpatients in the departments of general medicine, urology, obstetrics, and gynecology of a tertiary level referral hospital in south Malabar region of Kerala to assess the prevalence of various bacterial isolates and their changing susceptibility to antimicrobial agents and to evaluate the pattern of antibiotic utilization in urinary tract infection (UTI). METHODS: A total of 680 samples were analyzed from December 2015 to May 2016; among them, only 74 patients met the inclusion criteria...
July 31, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Richard J Fantus, Andrew Cohen, Christopher B Riedinger, Kristine Kuchta, Chi H Wang, Katharine Yao, Sangtae Park
To evaluate trends in contemporary robotic surgery across multiple organ sites as they relate to robotic prostatectomy volume. We queried the National Cancer Database for patients who underwent surgery from 2010 to 2013 for prostate, kidney, bladder, corpus uteri, uterus, cervix, colon, sigmoid, rectum, lung and bronchus. The trend between volumes of robotic surgery for each organ site was analyzed using the Cochran-Armitage test. Multivariable models were then created to determine independent predictors of robotic surgery within each organ site by calculating the odds ratio with 95% CI...
July 30, 2018: Journal of Robotic Surgery
Levent Isikay, Senol Tonyali, Gulden Aydog
PURPOSE: To determine if there is a correlation between the newly proposed Gleason grading system by the International Society of Urological Pathology and the Cancer of the Prostate Risk Assessment (CAPRA) score. MATERIAL AND METHODS: The records of all patients that underwent radical prostatectomy at our hospital between 2007 and 2013 were retrospectively reviewed. The study parameters included patient demographics, the percentage of pre-operative prostate biopsies positive for PCa, biopsy Gleason Score (GS), and pre- and post-operative PSA values...
July 30, 2018: Urology Journal
Sahin Kilic, Engin Kolukcu, Fikret Erdemir, Ismail Benli, Akgul Arici
PURPOSE: Benign prostatic hyperplasia (BPH), and erectile dysfunction (ED) are urological diseases which affect more than 50 % of men older than 50 years of age. It has been reported that 5-alpha-reductase inhibitors (5-ARIs) used in clinical studies for the treatment of BPH caused ED in 0.8-15.8% of the patients. The aim of this study is evaluation of the effects of oral finasteride and dutasteride on penile intracavernosal pressures and penile morphology in a rat model. MATERIALS AND METHODS: Thirty Wistar Albino strain male rats were randomized into control (n = 10), finasteride (n = 10), and dutasteride (n = 10) groups...
July 24, 2018: Urology Journal
Rodney U Anderson, David Wise, Brian H Nathanson
OBJECTIVE: To evaluate effectiveness of physical therapy, biofeedback, and/or cognitive behavioral therapy for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS). This symptom complex has resisted resolution from conventional urologic treatment of the prostate, which includes antibiotics, alpha-blockers, and analgesics. Beginning in 1995, a new paradigm was introduced viewing CP/CPPS as a psycho-neuromuscular disorder driven by protective pelvic floor guarding and psychosocial stress...
July 27, 2018: Urology
Mehrzad Lotfi, Reza Beheshti, Mohammad Reza Rouhezamin, Abbas Rezaianzadeh, Pouya Farhadi, Zeinab Daneshi
Background: Prostate cancer is the most common malignancy among the male population in the United States and the 3rd most common non-skin cancer among men in Iran. Its prevalence has shown a rising trend in recent decades. The aim of this study was to report the epidemiological features of prostate cancer in patients referred for prostate biopsy in the south of Iran and to evaluate the accuracy of the levels of the prostate-specific antigen (PSA) and the PSA-density (PSAD) as well as the extension of the disease in the prediction of the biological behavior of prostate cancer...
July 2018: Iranian Journal of Medical Sciences
Berna Aytac Vuruskan, Mine Ozsen, Burhan Coskun, Ulviye Yalcinkaya
PURPOSE: In this study we aimed to review urological soft tissue sarcomas of genitourinary tract that were diagnosed in our institution and their prognostic factors for survival. MATERIALS AND METHODS: The clinical and pathological records of 31 patients who had diagnosis of soft tissue sarcomas primarily originating from the genitourinary tract between 2005-2011 were reviewed. RESULTS: The most common site was kidney (17 cases, 54.8%), and most common diagnosis was leiomyosarcoma (11 cases, 35...
June 10, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Joost Egberts, Lorena A Grondhuis Palacios, Gerard J van der Wielen
A 64-year-old man was referred to our urology outpatient clinic with lower urinary tract symptoms (LUTS). During rectal examination a smooth nodule was identified. MRI-images showed a prostatic cyst, originating from the utriculus. An utriculus cyst is a relatively rare finding and originates from a persistent remnant of the Müllerian duct.
June 22, 2018: Nederlands Tijdschrift Voor Geneeskunde
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