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https://www.readbyqxmd.com/read/30333957/an-ex-vivo-tissue-culture-model-for-the-assessment-of-individualized-drug-responses-in-prostate-and-bladder-cancer
#1
Arjanneke F van de Merbel, Geertje van der Horst, Maaike H van der Mark, Janneke I M van Uhm, Erik J van Gennep, Peter Kloen, Lijkele Beimers, Rob C M Pelger, Gabri van der Pluijm
Urological malignancies, including prostate and bladder carcinoma, represent a major clinical problem due to the frequent occurrence of therapy resistance and the formation of incurable distant metastases. As a result, there is an urgent need for versatile and predictive disease models for the assessment of the individualized drug response in urological malignancies. Compound testing on ex vivo cultured patient-derived tumor tissues could represent a promising approach. In this study, we have optimized an ex vivo culture system of explanted human prostate and bladder tumors derived from clinical specimens and human cancer cell lines xenografted in mice...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30332601/canadian-urological-association-guideline-on-male-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia-mluts-bph-2018-update
#2
J Curtis Nickel, Lorne Aaron, Jack Barkin, Dean Elterman, Mahmoud Nachabé, Kevin C Zorn
No abstract text is available yet for this article.
October 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/30324096/reduced-sensitivity-of-multiparametric-mri-for-clinically-significant-prostate-cancer-in-men-under-the-age-of-50
#3
Ilan Gielchinsky, Matthijs J Scheltema, Thomas Cusick, John Chang, Ron Shnier, Daniel Moses, Warick Delprado, Quoc Nguyen, Carlo Yuen, Anne-Maree Haynes, Phillip D Stricker
Introduction: Three percent of all new diagnosed prostate cancer (PC) patients are under the age of 50. Multiparametric MRI (mpMRI) is considered as increasingly powerful tool for decision-making in diagnosis of PC and in some active surveillance protocols. Since prostate architecture changes with age, we evaluated the sensitivity of mpMRI to detect clinically significant PC in patients under the age of 50 compared to pair-matched older patients. Methods: Data from a prospective collected and ethics approved database were retrospectively analyzed...
2018: Research and Reports in Urology
https://www.readbyqxmd.com/read/30322726/prostate-cancer-in-transgender-women
#4
REVIEW
Matthew D Ingham, Richard J Lee, Dhara MacDermed, Aria F Olumi
INTRODUCTION: As the transgender patient population continues to increase, urologists and other providers who treat genitourinary malignancies will increasingly encounter cases of prostate cancer in transgender women. Little exists in the current literature to help summarize the challenges and opportunities which face this unique patient population. Similarly, little exists to provide guidance on how we may best diagnose, manage, and follow transgender women diagnosed with prostate cancer...
October 12, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/30322707/youtube-as-a-source-of-patient-information-for-transrectal-ultrasound-guided-biopsy-of-the-prostate
#5
N Jain, H Al-Hasani, A Kalic, F Gill, H Abboudi
AIM: To assess the quality of YouTube videos explaining transrectal ultrasound (TRUS)-guided biopsies of the prostate. MATERIALS AND METHODS: A search of YouTube was made for the terms "TRUS", "TRUS biopsy", "transrectal ultrasound", and "prostate biopsy". Videos were selected from the first 10 pages of results and reviewed by three authors against criteria based on written information from the British Association of Urological Surgeons...
October 12, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/30318331/askmusic-leveraging-a-clinical-registry-to-develop-a-new-machine-learning-model-to-inform-patients-of-prostate-cancer-treatments-chosen-by-similar-men
#6
Gregory B Auffenberg, Khurshid R Ghani, Shreyas Ramani, Etiowo Usoro, Brian Denton, Craig Rogers, Benjamin Stockton, David C Miller, Karandeep Singh
BACKGROUND: Clinical registries provide physicians with a means for making data-driven decisions but few opportunities exist for patients to interact with registry data to help make decisions. OBJECTIVE: We sought to develop a web-based system that uses a prostate cancer (CaP) registry to provide newly diagnosed men with a platform to view predicted treatment decisions based on patients with similar characteristics. DESIGN, SETTING, AND PARTICIPANTS: The Michigan Urological Surgery Improvement Collaborative (MUSIC) is a quality improvement consortium of urology practices that maintains a prospective registry of men with CaP...
October 11, 2018: European Urology
https://www.readbyqxmd.com/read/30311686/recommendations-for-conducting-invasive-urodynamics-for-men-with-lower-urinary-tract-symptoms-qualitative-interview-findings-from-a-large-randomized-controlled-trial-upstream
#7
Lucy E Selman, Cynthia A Ochieng, Amanda L Lewis, Marcus J Drake, Jeremy Horwood
AIMS: To capture in-depth qualitative evidence regarding attitudes to and experiences of urodynamic testing among men with lower urinary tract symptoms (LUTS) at each end of the clinical pathway. METHODS: Semi-structured interview study conducted within the Urodynamics for Prostate Surgery: Randomized Evaluation of Assessment Methods (UPSTREAM) trial, which randomized men to a care pathway including urodynamics or routine non-invasive tests from 26 secondary care urology sites across England...
October 12, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/30306544/naftopidil-for-the-treatment-of-lower-urinary-tract-symptoms-compatible-with-benign-prostatic-hyperplasia
#8
REVIEW
Eu Chang Hwang, Shreyas Gandhi, Jae Hung Jung, Mari Imamura, Myung Ha Kim, Ran Pang, Philipp Dahm
BACKGROUND: Benign prostatic hyperplasia (BPH) is a common condition in ageing men that may cause lower urinary tract symptoms (LUTS). Treatment aims are to relieve symptoms and prevent disease-related complications. Naftopidil is an alpha-blocker (AB) that has a high affinity for the A1d receptor that may have advantages in treating LUTS in this setting. This is an update of a Cochrane Review first published in 2009. Since that time, several large randomised controlled trials (RCTs) have been reported, making this update relevant...
October 11, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30301698/focal-therapy-in-localised-prostate-cancer-real-world-urological-perspective-explored-in-a-cross-sectional-european-survey
#9
Giancarlo Marra, Guillaume Ploussard, Piet Ost, Pieter J L De Visschere, Alberto Briganti, Giorgio Gandaglia, Derya Tilki, Christian I Surcel, Igor Tsaur, Roderick C N Van Den Bergh, Alexander Kretschmer, Hendrik Borgmann, Paolo Gontero, Hashim U Ahmed, Massimo Valerio
INTRODUCTION: The urological community's opinion over focal therapy (FT) for prostate cancer (PCa) has never been assessed. Our aim was to investigate the current opinion on FT in the European urological community. METHODS: A 25-item questionnaire was devised according to the Cherries checklist and distributed through SurveyMonkey using a web link from November 2016 to October 2017. After a pilot validation (n = 40 urologists), the survey was sent through EAU and 9 other national European urological societies mailing list...
October 6, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/30293946/current-use-of-three-dimensional-model-technology-in-urology-a-road-map-for-personalised-surgical-planning
#10
REVIEW
Francesco Porpiglia, Daniele Amparore, Enrico Checcucci, Riccardo Autorino, Matteo Manfredi, Giada Iannizzi, Cristian Fiori
CONTEXT: Despite the current era of "precision surgery", an unmet need for an optimal surgical planning and navigation still remains for most genitourinary malignancies. In this setting, the 3D virtual reconstruction of 2D cross-sectional imaging has been increasingly adopted to facilitate the surgeon in better understanding the surgical anatomy. OBJECTIVE: To provide a short overview of the most recent evidences on the current applications of 3D virtual and printed reconstructions in urologic surgery...
October 4, 2018: European Urology Focus
https://www.readbyqxmd.com/read/30293231/consensus-on-management-of-castration-resistant-prostate-cancer-on-behalf-of-the-urological-tumours-working-group-uroncor-of-the-spanish-society-of-radiation-oncology
#11
A Gómez-Caamaño, C González-San Segundo, I Henríquez, X Maldonado, A Zapatero
BACKGROUND: The knowledge in the field of castration-resistant prostate cancer (CRPC) is developing rapidly, with emerging new therapies and advances in imaging. Nonetheless, in multiple areas there is still a lack of or very limited evidence, and clear guidance from clinicians regarding optimal strategy is required. METHODS: A modified Delphi method, with 116 relevant questions divided into 7 different CRPC management topics, was used to develop a consensus statement by the URONCOR group...
October 6, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/30287277/what-do-the-guidelines-say-for-metastatic-prostate-cancer-starting-androgen-deprivation-therapy-national-comprehensive-cancer-network-european-society-for-medical-oncology-and-european-association-of-urology-recommendations
#12
REVIEW
Evan Y Yu, Silke Gillessen, Nicolas Mottet
Clinical trial data forms the foundation of how we treat men with metastatic prostate cancer who are initiating therapy. However, clinical trial data does not answer everything; hence, good clinical practice, pragmatism, and occasionally extrapolation drives how we manage these patients. Fortunately, multiple international guideline committees meet regularly and offer clinical guidance. In this mini-review, we focus on the United States National Comprehensive Cancer Network, European Society for Medical Oncology, and European Association of Urology (EAU) recommendations for the initial treatment of metastatic prostate cancer...
October 1, 2018: European Urology Focus
https://www.readbyqxmd.com/read/30281352/developing-a-new-one-stop-urology-diagnostics-service
#13
Sarah Hillery
A newly built NHS 'one-stop' urology diagnostics unit has been created to provide a genuinely patient-centred experience for all new patients presenting with urological symptoms. Patients across the region now receive not only their initial specialist consultation, but also all diagnostic investigations and a treatment plan during a single visit to the unit. The purpose-built service has reduced the patient diagnostic pathway from several visits over many weeks to a matter of hours. The unit has facilities for urodynamic studies, ultrasound, flexible cystoscopy and trans-rectal ultrasound prostate biopsy in addition to full physiological measurement capabilities...
October 4, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/30280090/the-role-of-immunohistochemical-analysis-as-a-tool-for-the-diagnosis-prognostic-evaluation-and-treatment-of-prostate-cancer-a-systematic-review-of-the-literature
#14
Arie Carneiro, Álan Roger Gomes Barbosa, Lucas Seiti Takemura, Paulo Priante Kayano, Natasha Kouvaleski Saviano Moran, Carolina Ko Chen, Marcelo Langer Wroclawski, Gustavo Caserta Lemos, Isabela Werneck da Cunha, Marcos Takeo Obara, Marcos Tobias-Machado, Adam G Sowalsky, Bianca Bianco
Background: Prostate cancer (PCa) is a heterogeneous disease that lends itself toward numerous therapeutic options depending on its risk stratification. One of the greatest challenges in PCa urologic practice is to select patients who should be referred for biopsy and, for those patients who are diagnosed with cancer, to differentiate between patients with indolent disease from those with an unfavorable prognosis and, to determine ideal patient management and avoid unnecessary interventions. Accordingly, there is a growing body of literature reporting immunohistochemical studies with the objective of determining a prostate cancer prognosis...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30277739/urinary-retention-in-adults-evaluation-and-initial-management
#15
David C Serlin, Joel J Heidelbaugh, John T Stoffel
Urinary retention is the acute or chronic inability to voluntarily pass an adequate amount of urine. The condition predominantly affects men. The most common causes are obstructive in nature, with benign prostatic hyperplasia accounting for 53% of cases. Infectious, inflammatory, iatrogenic, and neurologic causes can also affect urinary retention. Initial evaluation should involve a detailed history that includes information about current prescription medications and use of over-the-counter medications and herbal supplements...
October 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/30273380/meta-analysis-of-the-association-between-the-inflammatory-potential-of-diet-and-urologic-cancer-risk
#16
Dong-Liang Lu, Zheng-Ju Ren, Qin Zhang, Peng-Wei Ren, Bo Yang, Liang-Ren Liu, Qiang Dong
BACKGROUND: The inflammatory potential of diet has been shown to have an association with the risk of several cancer types, but the evidence is inconsistent regarding the related risk of urologic cancer (UC). Therefore, we conducted the present meta-analysis to investigate the association between the inflammatory potential of diet and UC. METHODS: PubMed, Embase and Web of Science were searched up to July 31, 2018. Two reviewers independently selected the studies and extracted the data...
2018: PloS One
https://www.readbyqxmd.com/read/30271757/inflammatory-mechanisms-and-oxidative-stress-in-prostatitis-the-possible-role-of-antioxidant-therapy
#17
REVIEW
Gianni Paulis
This article focuses on the role that oxidative stress plays in chronic prostatitis, not only with respect to the known impact on symptoms and fertility but also especially in relation to possible prostate cancer development. Prostatitis is the most common urologic disease in adult males younger than 50 years and the third most common urologic diagnosis in males older than 50 years. If the germ-causing acute prostatitis is not eliminated, the inflammatory process becomes chronic. Persistent inflammation causes ongoing production of large quantities of pro-inflammatory cytokines and both oxygen and nitrogen reactive species, with consequent activation of transcription factor nuclear factor-kappa B (NF-κB) and genes encoding for further production of pro-inflammatory cytokines, chemotactic factors, and growth factors...
2018: Research and Reports in Urology
https://www.readbyqxmd.com/read/30270510/national-and-subnational-mortality-of-urological-cancers-in-iran-1990-2015
#18
Farhad Pishgar, Erfan Amini, Kimiya Gohari, Arya Aminorroaya, Ali Sheidaei, Yasna Rostamabadi, Hooman Ebrahimi, Moein Yoosefi, Shohreh Naderimagham, Nazila Rezaei, Mitra Modirian, Alireza Namazi Shabestari, Farzad Kompani, Farshad Farzadfar
PURPOSE: To study trends of urological cancers mortalities in Iran between 1990 and 2015 as a part of a larger project named national and subnational burden of diseases, injuries, and risk factors. METHODS: The primary dataset of this project comprises data of national death registration system. Cause-specific mortality fraction for each age, sex, province, and year group was calculated using a two-stage mixed effects and spatiotemporal models, and then these fractions were applied to all-cause mortality rates, obtained from a parallel study to estimate mortality rates attributable to each cause...
October 1, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30270128/the-role-of-urinary-microbiota-in-lower-urinary-tract-dysfunction-a-systematic-review
#19
REVIEW
Tiago Antunes-Lopes, Luis Vale, Ana Margarida Coelho, Carlos Silva, Malte Rieken, Bogdan Geavlete, Tina Rashid, Sajjad M Rahnama'i, Jean Nicolas Cornu, Tom Marcelissen
CONTEXT: Until 2012, the urinary tract of healthy individuals was considered to be sterile. The advent of metagenomic sequencing revealed a unique urinary microbiota (UM). This paradigm shift appears to have prolific implications in the etiology of several functional lower urinary tract (LUT) disorders. OBJECTIVE: To systematically summarize recent data on the role of UM in LUT dysfunction. EVIDENCE ACQUISITION: We performed a critical review according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement...
September 27, 2018: European Urology Focus
https://www.readbyqxmd.com/read/30267499/-concordance-evaluation-of-gleason-score-between-laparoscopic-prostatectomy-and-needle-biopsy-specimens
#20
Marcin Cichocki, Tomasz Konecki, Zbigniew Jabłonowski
OBJECTIVE: Introduction: Prostate cancer is currently one of the most important health issues especially for developed countries. It is the most common solid organ malignancy amongst men in Europe with 214 new cases per 100.000 men per year and the second most common cause of cancer death. The choice of therapy depends upon the clinical stage (cTNM), PSA level and Gleason histological score. Gleason score of radical prostatectomy specimens is the strongest predictor of disease progression...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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