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JOURNAL ARTICLE
Magdalena Jasińska-Stroschein, Justyna Dymek, Mariola Drozd, Olga Sierpniowska, Artur Jędra, Agnieszka Stankiewicz, Paulina Stasiak, Sylwia Cholewa, Magdalena Nowakowska, Magdalena Waszyk-Nowaczyk
BACKGROUND: The New Medicine Service (NMS) was developed in England more than ten years ago, as a three-stage consultation led by community pharmacists to support patients taking new medication for a chronic disease. In Poland, the scheme was officially introduced in January 2023. However, its implementation into common practice has been presented with various obstacles, including the need to develop relationships with general practitioners, resolve the payment structure, and provide training with adequate supporting materials...
May 10, 2024: BMC Medical Education
#22
RANDOMIZED CONTROLLED TRIAL
Ruth Ndjaboue, Caroline Beaudoin, Sandrine Comeau, Anne Dagnault, Maman Joyce Dogba, Sarah Numainville, Charles Racine, Sharon Straus, Marie-Claude Tremblay, Holly O Witteman
PURPOSE: Many health professions education programs involve people with lived experience as expert speakers. Such presentations may help learners better understand the realities of living with chronic illness or experiencing an acute health problem. However, lectures from only one or a small number of people may not adequately illustrate the perspectives and experiences of a diverse patient cohort. Additionally, logistical constraints such as public health restrictions or travel barriers may impede in-person presentations, particularly among people who have more restrictions on their time...
May 10, 2024: BMC Medical Education
#23
JOURNAL ARTICLE
Hiroki Yagura, Dai Watanabe, Takao Nakauchi, Hiroyuki Kushida, Kazuyuki Hirota, Yasuharu Nishida, Munehiro Yoshino, Tomoko Uehira, Takuma Shirasaka
BACKGROUND: The relationship between plasma tenofovir (TFV) concentration at the beginning of tenofovir disoproxil fumarate (TDF) administration and the development of renal dysfunction during long-term administration of TDF has not been demonstrated yet. The objective of the present study was to determine whether plasma TFV trough concentrations during early TDF administration could serve as an indicator of renal dysfunction when TDF is administered for long periods. METHODS: We included 149 HIV-1 infected Japanese patients who were prescribed TDF...
May 10, 2024: Journal of Pharmaceutical Health Care and Sciences
#24
JOURNAL ARTICLE
Ricard Mellado-Artigas, Xavier Borrat, Bruno L Ferreyro, Christopher Yarnell, Sicheng Hao, Kerollos N Wanis, Enric Barbeta, Antoni Torres, Carlos Ferrando, Laurent Brochard
PURPOSE: Invasive ventilation is a fundamental treatment in intensive care but its precise timing is difficult to determine. This study aims at assessing the effect of initiating invasive ventilation versus waiting, in patients with hypoxemic respiratory failure without immediate reason for intubation on one-year mortality. METHODS: Emulation of a target trial to estimate the benefit of immediately initiating invasive ventilation in hypoxemic respiratory failure, versus waiting, among patients within the first 48-h of hypoxemia...
May 10, 2024: Critical Care: the Official Journal of the Critical Care Forum
#25
JOURNAL ARTICLE
Martin Thornhill, Bernard Prendergast, Mark Dayer, Ash Frisby, Peter Lockhart, Larry M Baddour
In 2008, National Institute for Health and Care Excellence (NICE) guidelines recommended against the use of antibiotic prophylaxis (AP) before invasive dental procedures (IDPs) to prevent infective endocarditis (IE). They did so because of lack of AP efficacy evidence and adverse reaction concerns. Consequently, NICE concluded AP was not cost-effective and should not be recommended. In 2015, NICE reviewed its guidance and continued to recommend against AP. However, it subsequently changed its wording to 'antibiotic prophylaxis against infective endocarditis is not routinely recommended'...
May 2024: British Dental Journal
#26
JOURNAL ARTICLE
Elizabeth Miles, Richa Arya, Christopher Sproat, Vinod Patel
The continuation of bone-modifying agents (BMAs) in patients with established medication-related osteonecrosis of the jaw (MRONJ) is a common concern among dentists and oncologists. There is little evidence supporting or refuting the continued use of BMAs or drug holidays and their impact on established MRONJ. This paper evaluates the outcome of continued BMAs use on the patient's MRONJ status. A retrospective review of 29 oncology patients undergoing active cancer care for either metastatic disease or multiple myeloma was conducted...
May 2024: British Dental Journal
#27
JOURNAL ARTICLE
Shykina Brown, Oscar F Rojas Perez
Mental health concerns among juvenile-justice-involved youth (JJIY) continue to be a major health crisis in the United States (US). While scholarship has explored mental health concerns among JJIY, and the link to negative life outcomes, there are gaps in the existing research, particularly in effective interventions and models aimed at addressing both the mental health concerns and criminogenic risk contributing to recidivism and other negative life outcomes of this population. In this paper, we present Justice-Based Interdisciplinary Collective Care (JBICC), an innovative framework to address both the mental health needs and delinquent behavior of youth offenders...
May 10, 2024: Community Mental Health Journal
#28
JOURNAL ARTICLE
Yeliz Suna Dağ, Emriye Hilal Yayan
OBJECTIVE: To investigate the effects of facilitated tucking and white noise on stress and sleep in neonates receiving nasal continuous positive airway pressure (CPAP). METHOD: This study was conducted as a randomised controlled experimental study of neonates receiving nasal CPAP in neonatal intensive care units. The study sample consisted of 108 newborns (facilitated tucking (n = 36), white noise (n = 36) and control (n = 36)) receiving nasal CPAP support in the NICU...
May 9, 2024: Journal of Pediatric Nursing
#29
MULTICENTER STUDY
Anders L Carlson, Roy W Beck, Zoey Li, Elizabeth Norton, Richard M Bergenstal, Mary Johnson, Sean Dunnigan, Matthew Banfield, Katie J Krumwiede, Judy R Sibayan, Peter Calhoun, Celeste Durnwald
INTRODUCTION: To characterize glucose levels during uncomplicated pregnancies, defined as pregnancy with a hemoglobin A1c <5.7% (<39 mmol/mol) in early pregnancy, and without a large-for-gestational-age birth, hypertensive disorders of pregnancy, or gestational diabetes mellitus (ie, abnormal oral glucose tolerance test). RESEARCH DESIGN AND METHODS: Two sites enrolled 937 pregnant individuals aged 18 years and older prior to reaching 17 gestational weeks; 413 had an uncomplicated pregnancy (mean±SD body mass index (BMI) of 25...
May 10, 2024: BMJ Open Diabetes Research & Care
#30
JOURNAL ARTICLE
Justine Chinnappan, Rami Al-Handola, Noyal M Joseph, Ekwevugbe Ogbon, Philip J McDonald
UNLABELLED: Stress ulcer prophylaxis is started in the critical care unit to decrease the risk of upper gastrointestinal ulcers in critically ill persons and to decrease mortality caused by stress ulcer complications. Unfortunately, the drugs are often continued after recovery through discharge, paving the way for unnecessary polypharmacy. STUDY DESIGN: We conducted a retrospective cross-sectional study including patients admitted to the adult critical care unit and started on the stress ulcer prophylaxis with a proton pump inhibitor (PPI) or histamine receptor 2 blocker (H2 blocker) with an aim to determine the prevalence of inappropriate continuation at discharge and associated factors...
May 10, 2024: BMJ Open Quality
#31
JOURNAL ARTICLE
Reema Garegrat, Atul Londhe, Swati Manerkar, Sudhindrashayana Fattepur, Laxmikant Deshmukh, Amol Joshi, Savitha Chandriah, Mallesh Kariyappa, Sahana Devadas, Theranirajan Ethirajan, Kalaivani Srivasan, Chinnathambi Kamalarathnam, Anitha Balachandran, Elango Krishnan, Deepthy Sahayaraj, Prathik Bandiya, Niranjan Shivanna, Constance Burgod, Ashwini Thayyil, Annie Alocious, Marianna Lanza, Pallavi Muraleedharan, Stuti Pant, Harini Venkateswaran, Maria Moreno Morales, Paolo Montaldo, Vaisakh Krishnan, Thaslima Kalathingal, Anagha Rajeev Joshi, Ajay Vare, G C Patil, Babu Peter Satyanathan, Pavan Hapat, Abhishek Deshmukh, Indramma Shivarudhrappa, Manjesh Kurupalya Annayappa, Mythili Baburaj, Christina Muradi, Esprance Fernandes, Nishad Thale, Ismat Jahan, Mohammed Shahidullah, Sadeka Moni Choudhury, Sanjoy Kumer Dey, Sutapa B Neogi, Rupsa Banerjee, Vanessa Rameh, Farah Alobeidi, Ellen Grant, Sandra E Juul, Martin Wilson, Enrico De Vita, Ronit Pressler, Paul Bassett, Seetha Shankaran, Sudhin Thayyil
OBJECTIVE: To examine the feasibility of early and extended erythropoietin monotherapy after hypoxic ischaemic encephalopathy (HIE). DESIGN: Double-blind pilot randomised controlled trial. SETTING: Eight neonatal units in South Asia. PATIENTS: Neonates (≥36 weeks) with moderate or severe HIE admitted between 31 December 2022 and 3 May 2023. INTERVENTIONS: Erythropoietin (500 U/kg daily) or to the placebo (sham injections using a screen) within 6 hours of birth and continued for 9 days...
May 10, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
#32
REVIEW
Rosemijne R W P Pigmans, Jonathan M Smith, Dick G Markhorst, Job B M van Woensel, Coen D Dijkman, Heather E Elphick, Reinout A Bem
Non-invasive respiratory support delivered through a face mask has become a cornerstone treatment for adults and children with acute or chronic respiratory failure. However, an imperfect mask fit using commercially available interfaces is frequently encountered, which may result in patient discomfort and treatment inefficiency or failure. To overcome this challenge, over the last decade increasing attention has been given to the development of personalized face masks, which are custom made to address the specific facial dimensions of an individual patient...
May 10, 2024: Respiratory Care
#33
JOURNAL ARTICLE
Anand Naik Bukke, Dheepak M Sundar, Rohan Chawla, Chandradevi Shanmugam
A late adolescent with tuberous sclerosis (TS) presented with reduced vision in one eye to our tertiary care university hospital 4 years ago. Fundus examination revealed multiple retinal astrocytic hamartomas (RAHs) in both eyes. His younger sibling, who also had TS, was found to have RAH on retinal screening. The swept-source optical coherence tomography (SS-OCT) findings were typical of RAH. We further noted that some of the RAH lesions showed segmental whitening of the outer walls of the arterioles, which traversed through them...
May 10, 2024: BMJ Case Reports
#34
JOURNAL ARTICLE
Jonathan L Meakins, Liane S Feldman
SummaryIn 1923, just over 100 years ago, Edward William Archibald was appointed the first chair of surgery in McGill University's Faculty of Medicine. This milestone provides an opportunity to reflect on where the department has come from and how it has progressed to the present day. Although the size, breadth, and diversity of the department members have changed notably over the century, the core values of innovative clinical care, research, and education established a century ago continue to this day. To reflect his values, the Archibald Chair of Surgery was established in 1990 and is today held by the department chair...
2024: Canadian Journal of Surgery. Journal Canadien de Chirurgie
#35
JOURNAL ARTICLE
Kristen L Flint, Felippe O Marcondes
No abstract text is available yet for this article.
May 8, 2024: Endocrine Practice
#36
JOURNAL ARTICLE
Naomi Takemura, Denise Shuk Ting Cheung, Daniel Yee Tak Fong, David Hui, Anne Wing Mui Lee, Tai-Chung Lam, James Chung-Man Ho, Tsz Yeung Kam, Jeannie Yin Kwan Chik, Chia-Chin Lin
CONTEXT: Dyspnea, a prevalent and debilitating symptom in patients with advanced lung cancer, negatively affects symptom burden and prognosis. Physical activity has emerged as a promising non-pharmacological intervention for managing dyspnea. OBJECTIVES: This study compared the effectiveness of two widely-recognized physical activity modalities, namely Tai Chi (TC) and aerobic exercise (AE) for treating dyspnea in patients with advanced lung cancer. METHODS: Patients with advanced lung cancer (n=226) were randomized into TC, AE, or control groups...
May 8, 2024: Journal of Pain and Symptom Management
#37
JOURNAL ARTICLE
Govardhan Katta Radhakrishna, Damodar Nayak Ammunje, Selvaraj Kunjiappan, Kaveena Ravi, Shangavi Vellingiri, Sameera Hammigi Ramesh, Shannon D Almeida, Golla Sireesha, Soundarya Ramesh, Saud Al-Qahtani, Kumarappan Chidamabaram, Panneerselvam Theivendren, Parasuraman Pavadai
This study examines the fundamental chemical mechanisms responsible for capsaicin's advantageous impact on cancer, specifically investigating its influence on several biological processes such as inflammation in cancer metastasis, apoptosis, angiogenesis, and cellular proliferation. This entity's connections with other signaling pathways, including PI3K/AKT, NF-B, and TRPV channels, which have been linked to tumor growth, are thoroughly examined in this work. This study presents a thorough analysis of preclinical studies and clinical trials investigating the efficacy of capsaicin in treating many forms of cancer, such as breast, prostate, colorectal, pancreatic, and others...
May 10, 2024: Drug Research
#38
JOURNAL ARTICLE
Anna DeLaRosby, Julie Mulcahy, Todd Norwood
The continued demand for digital health requires that providers adapt thought processes to enable sound clinical decision making in digital settings. Providers report that lack of training is a barrier to providing digital healthcare. Physical exam techniques and hands-on interventions must be adjusted in safe, reliable and feasible ways to digital care and decision making may be impacted by modifications made to these techniques. We have proposed a framework for determining if a procedure can be modified to obtain a comparable result in a digital environment or if a referral to in-person care is required...
May 9, 2024: JMIR Medical Education
#39
JOURNAL ARTICLE
Hiba Abbasi, Christine Vandenhouten, Regina H Johnson, Krista Jones
BACKGROUND: Policy, societal, and system changes are prompting nursing programs to expand population health content in curricula. This study examined the current state of community, public, and population health (CPPH) education in nursing curricula throughout the United States. METHOD: This descriptive study examined CPPH education in nursing programs nationally. A survey was developed and distributed to nursing programs from January to May 2021. RESULTS: CPPH content integration occurred across all program levels, and the majority of the participants were involved in the development of CPPH-specific curriculum...
May 2024: Journal of Nursing Education
#40
JOURNAL ARTICLE
Shuai-Kang Wang, Qi-Jun Wang, Peng Wang, Xiang-Yu Li, Peng Cui, Dong-Fan Wang, Xiao-Long Chen, Chao Kong, Shi-Bao Lu
BACKGROUND: Frailty is recognized as a surrogate for physiological age and has been established as a valid and independent predictor of postoperative morbidity, mortality, and complications. ERAS can enhance surgical safety by minimizing stress responses in frail patients, enabling surgeons to discharge patients earlier. However, the question of whether and to what extent the frailty impacts the post-ERAS outcomes in older patients remains. MATERIALS AND METHODS: An evidence-based ERAS program was implemented in our center from January 2019...
May 9, 2024: International Journal of Surgery
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