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https://www.readbyqxmd.com/read/28819116/silencing-of-tgf-%C3%AE-1-in-tumor-cells-impacts-mmp-9-in-tumor-microenvironment
#1
Lakisha D Moore-Smith, Tatyana Isayeva, Joo Hyoung Lee, Andra Frost, Selvarangan Ponnazhagan
Transforming growth factor (TGF)-β1 contributes to autocrine and paracrine functions in the tumor microenvironment (TME). The present study examined the effects of TGF-β1 crosstalk in TME and its role in mediating tumor formation and progression by targeted abrogation of TGF-β1 expression in metastatic cells in situ. Using species-specific primers, we found a significant increase in MMP-9 gene expression in the tumor-reactive stroma during late-stage metastasis in the lung. This effect was also confirmed in cancer-associated fibroblasts (CAFs) when co-cultured with the tumor cells...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814667/adrenergic-mediated-increases-in-inhba-drive-caf-phenotype-and-collagens
#2
Archana S Nagaraja, Robert L Dood, Guillermo Armaiz-Pena, Yu Kang, Sherry Y Wu, Julie K Allen, Nicholas B Jennings, Lingegowda S Mangala, Sunila Pradeep, Yasmin Lyons, Monika Haemmerle, Kshipra M Gharpure, Nouara C Sadaoui, Cristian Rodriguez-Aguayo, Cristina Ivan, Ying Wang, Keith Baggerly, Prahlad Ram, Gabriel Lopez-Berestein, Jinsong Liu, Samuel C Mok, Lorenzo Cohen, Susan K Lutgendorf, Steve W Cole, Anil K Sood
Adrenergic signaling is known to promote tumor growth and metastasis, but the effects on tumor stroma are not well understood. An unbiased bioinformatics approach analyzing tumor samples from patients with known biobehavioral profiles identified a prominent stromal signature associated with cancer-associated fibroblasts (CAFs) in those with a high biobehavioral risk profile (high Center for Epidemiologic Studies Depression Scale [CES-D] score and low social support). In several models of epithelial ovarian cancer, daily restraint stress resulted in significantly increased CAF activation and was abrogated by a nonspecific β-blocker...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28808957/differential-effect-of-tgf%C3%AE-on-the-proteome-of-cancer-associated-fibroblasts-and-cancer-epithelial-cells-in-a-co-culture-approach-a-short-report
#3
Maria Magdalena Koczorowska, Charlotte Friedemann, Klaus Geiger, Marie Follo, Martin Lothar Biniossek, Oliver Schilling
BACKGROUND: Solid tumors contain various components that together form the tumor microenvironment. Cancer associated fibroblasts (CAFs) are capable of secreting and responding to signaling molecules and growth factors. Due to their role in tumor development, CAFs are considered as potential therapeutic targets. A prominent tumor-associated signaling molecule is transforming growth factor β (TGFβ), an inducer of epithelial-to-mesenchymal transition (EMT). The differential action of TGFβ on CAFs and ETCs (epithelial tumor cells) has recently gained interest...
August 14, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28802099/cancer-associated-fibroblasts-autophagy-enhances-progression-of-triple-negative-breast-cancer-cells
#4
Mengchuan Wang, Jian Zhang, Yizhe Huang, Shufeng Ji, Guoli Shao, Shaobo Feng, Danxun Chen, Kankan Zhao, Zixiang Wang, Aiguo Wu
BACKGROUND Cancer-associated fibroblasts (CAFs) are key factors in malignant tumor initiation, progression, and metastasis. However, the effect of CAFs autophagy on triple-negative breast cancer (TNBC) cells is not clear. In this study, the growth effect of TNBC cells regulated by CAFs autophagy was evaluated. MATERIAL AND METHODS CAFs were obtained from invasive TNBC tumors and identified by Western blot and immunofluorescence staining assay. CAFs were co-cultured with TNBC cells, and migration and invasion were evaluated by Matrigel-coated Transwell and Transwell inserts...
August 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28802057/hmgb1-released-by-autophagic-cancer-associated-fibroblasts-maintains-the-stemness-of-luminal-breast-cancer-cells
#5
Xi-Long Zhao, Yong Lin, Jun Jiang, Zhuo Tang, Shuai Yang, Lu Lu, Yan Liang, Xue Liu, Jiao Tan, Xu-Gang Hu, Qin Niu, Wen-Juan Fu, Ze-Xuan Yan, De-Yu Guo, Yi-Fang Ping, Ji Ming Wang, Xia Zhang, Hsiang-Fu Kung, Xiu-Wu Bian, Xiao-Hong Yao
Cancer stem/initiating cells (CSCs/CICs) and their microenvironmental niche play a vital role in malignant tumour recurrence and metastasis. Cancer associated fibroblasts (CAFs) are major components of the niche of breast cancer initiating cells (BCICs) and their interactions may profoundly affect breast cancer progression. Autophagy has been considered as a critical process for CIC maintenance, but whether it is involved in the cross-talk between CAFs and CICs to affect tumourigenesis and pathological significance remains elusive...
August 12, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28799592/rapid-determination-of-the-tumour-stroma-ratio-in-squamous-cell-carcinomas-with-desorption-electrospray-ionization-mass-spectrometry-desi-ms-a-proof-of-concept-demonstration
#6
Michael Woolman, Alessandra Tata, Delaram Dara, Jalna Meens, Elisa D'Arcangelo, Consuelo J Perez, Shamina Saiyara Prova, Emma Bluemke, Howard J Ginsberg, Demian Ifa, Alison McGuigan, Laurie Ailles, Arash Zarrine-Afsar
Squamous cell carcinomas constitute a major class of head & neck cancers, where the tumour stroma ratio (TSR) carries prognostic information. Patients affected by stroma-rich tumours exhibit a poor prognosis and a higher chance of relapse. As such, there is a need for a technology platform that allows rapid determination of the tumour stroma ratio. In this work, we provide a proof-of-principle demonstration that Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) can be used to determine tumour stroma ratios...
August 11, 2017: Analyst
https://www.readbyqxmd.com/read/28793962/simultaneous-extraction-and-concentration-of-water-pollution-tracers-using-ionic-liquid-based-systems
#7
Teresa B V Dinis, Helena Passos, Diana L D Lima, Ana C A Sousa, João A P Coutinho, Valdemar I Esteves, Mara G Freire
Human activities are responsible for the release of innumerous substances into the aquatic environment. Some of these substances can be used as pollution tracers to identify contamination sources and to prioritize monitoring and remediation actions. Thus, their identification and quantification are of high priority. However, due to their presence in complex matrices and at significantly low concentrations, a pre-treatment/concentration step is always required. As an alternative to the currently used pre-treatment methods, mainly based on solid-phase extractions, aqueous biphasic systems (ABS) composed of ionic liquids (ILs) and K3C6H5O7 are here proposed for the simultaneous extraction and concentration of mixtures of two important pollution tracers, caffeine (CAF) and carbamazepine (CBZ)...
July 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28782893/prognostic-value-of-the-immunohistochemical-detection-of-cancer-associated-fibroblasts-in-oral-cancer-a-systematic-review-and-meta-analysis
#8
REVIEW
Mauricio Rocha Dourado, Eliete N S Guerra, Tuula Salo, Daniel W Lambert, Ricardo D Coletta
AIM: To perform a meta-analysis to assess whether the presence of cancer-associated fibroblasts (CAF) is a prognostic marker of oral squamous cell carcinomas (OSCC). METHODS: Immunohistochemical studies assessing the prognostic relevance of CAF (alpha smooth muscle actin (α-SMA)-positive fibroblasts) in patients with OSCC were systematically reviewed using Cochrane, Lilacs, PubMed, Scopus and Web of Science databases. The outcomes assessed were overall survival (OS) and disease-free survival (DFS)...
August 7, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28776672/mechanisms-involved-in-the-cytotoxic-action-of-brazilian-propolis-and-caffeic-acid-against-hep-2-cells-and-modulation-of-p-glycoprotein-activity
#9
Lívia M da Silva, Yahima Frión-Herrera, Ariane R Bartolomeu, Carolina Mendonça Gorgulho, José M Sforcin
OBJECTIVES: The effects of propolis and phenolic compounds (caffeic acid - Caf; dihydrocinnamic acid - Cin; p-coumaric acid - Cou) in the same quantity found in our propolis sample were investigated on human laryngeal epidermoid carcinoma (HEp-2) cells. METHODS: Cell viability, apoptosis/necrosis and cell cycle arrest, P53 and CASPASE-3 gene expression, generation of reactive oxygen species (ROS) and the ability of propolis to induce doxorubicin (DOX) efflux using a P-glycoprotein (P-gp) inhibitor (verapamil) were assayed...
August 4, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28775239/reversion-of-epithelial-mesenchymal-transition-by-a-novel-agent-dz-50-via-igf-binding-protein-3-in-prostate-cancer-cells
#10
Zheng Cao, Shahriar Koochekpour, Stephen E Strup, Natasha Kyprianou
Dysregulation of transforming growth factor-β1 (TGF-β1) and insulin-like growth factor (IGF) axis has been linked to reactive stroma dynamics in prostate cancer progression. IGF binding protein-3 (IGFBP3) induction is initiated by stroma remodeling and could represent a potential therapeutic target for prostate cancer. In previous studies a lead quinazoline-based Doxazosin® derivative, DZ-50, impaired prostate tumor growth by targeting proteins involved in focal adhesion, anoikis resistance and epithelial-mesenchymal-transition (EMT)...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28770196/functionality-of-immunoglobulin-g-and-immunoglobulin-m-antibody-physisorbed-on-cellulosic-films
#11
Ziwei Huang, Vikram Singh Raghuwanshi, Gil Garnier
The functionality and aging mechanism of antibodies physisorbed onto cellulosic films was investigated. Blood grouping antibodies immunoglobulin G (IgG) and immunoglobulin M (IgM) were adsorbed onto smooth cellulose acetate (CAF) and regenerated cellulose (RCF) films. Cellulose films and adsorbed IgG layers were characterized at the air and liquid interface by X-ray and neutron reflectivity (NR), respectively. Cellulose film 208 Å thick (in air) swell to 386 Å once equilibrated in water. IgG adsorbs from solution onto cellulose as a partial layer 62 Å thick...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28754894/a-cancer-stem-cell-model-as-the-point-of-origin-of-cancer-associated-fibroblasts-in-tumor-microenvironment
#12
Neha Nair, Anna Sanchez Calle, Maram Hussein Zahra, Marta Prieto-Vila, Aung Ko Ko Oo, Laura Hurley, Arun Vaidyanath, Akimasa Seno, Junko Masuda, Yoshiaki Iwasaki, Hiromi Tanaka, Tomonari Kasai, Masaharu Seno
Cancer-associated fibroblasts (CAFs) are one of the most prominent cell types in the stromal compartment of the tumor microenvironment. CAFs support multiple aspects of cancer progression, including tumor initiation, invasion, and metastasis. The heterogeneous nature of the stromal microenvironment is attributed to the multiple sources from which the cells in this compartment originate. The present study provides the first evidence that cancer stem cells (CSCs) are one of the key sources of CAFs in the tumor niche...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28753257/caffeic-acid-attenuates-the-inflammatory-stress-induced-by-glycated-ldl-in-human-endothelial-cells-by-mechanisms-involving-inhibition-of-age-receptor-oxidative-and-endoplasmic-reticulum-stress
#13
Laura Toma, Gabriela M Sanda, Loredan S Niculescu, Mariana Deleanu, Camelia S Stancu, Anca V Sima
Type 2 diabetes mellitus is a worldwide epidemic and its atherosclerotic complications determine the high morbidity and mortality of diabetic patients. Caffeic acid (CAF), a phenolic acid present in normal diets, is known for its antioxidant properties. The aim of this study was to investigate CAF's anti-inflammatory properties and its mechanism of action, using cultured human endothelial cells (HEC) incubated with glycated low-density lipoproteins (gLDL). Levels of the receptor for advanced glycation end-products (RAGE), inflammatory stress markers (C reactive protein, CRP; vascular cell adhesion molecule-1, VCAM-1; monocyte chemoattractant protein-1, MCP-1), and oxidative stress and endoplasmic reticulum stress (ERS) markers were evaluated in gLDL-exposed HEC, in the presence/absence of CAF...
July 28, 2017: BioFactors
https://www.readbyqxmd.com/read/28753100/xenogenous-collagen-matrix-and-or-enamel-matrix-derivative-for-treatment-of-localized-gingival-recessions-a-randomized-clinical-trial-part-i-clinical-outcomes
#14
João Paulo Sangiorgio, Felipe Lucas da Silva Neves, Manuela Rocha Dos Santos, Isabela Lima França-Grohmann, Renato Corrêa Viana Casarin, Márcio Zaffalon Casati, Mauro Pedrine Santamaria, Enilson Antonio Sallum
BACKGROUND: Considering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is suggested that their combination could promote superior clinical outcomes in root coverage procedures. Thus, the aim of this parallel, double-blinded, dual-centre, randomized clinical trial was to evaluate the clinical outcomes after treatment of localized gingival recession by coronally advanced flap (CAF) combined with CM and/or enamel matrix derivative (EMD). METHODS: Sixty-eight patients presenting one Miller Class I or II gingival recessions were randomly assigned to receive either CAF (n=17); CAF + CM (n=17); CAF+EMD (n=17) or CAF+CM+EMD (n=17)...
July 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28753098/xenogenous-collagen-matrix-and-or-enamel-matrix-derivative-for-treatment-of-localized-gingival-recessions-a-randomized-clinical-trial-part-ii-patient-reported-outcomes
#15
Manuela Rocha Dos Santos, João Paulo Menck Sangiorgio, Felipe Lucas da Silva Neves, Isabela Lima França-Grohmann, Francisco Humberto Nociti, Karina Gonzales Silverio Ruiz, Mauro Pedrine Santamaria, Enilson Antonio Sallum
BACKGROUND: Gingival recession (GR) might be associated with patient discomfort due to cervical dentin hypersensitivity (CDH) and esthetics dissatisfaction. The aim is to evaluate the effect of root coverage procedure with xenogeneic collagen matrix (CM) and/or enamel matrix derivative (EMD) in combination with the coronally advanced flap (CAF) on CDH, esthetics and quality of life of patients with GR. METHODS: Sixty-eight participants with single Miller I/II GRs were treated with CAF (n = 17), CAF + CM (n = 17), CAF + EMD (n = 17) and CAF + CM + EMD (n = 17)...
July 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28752826/realization-of-wide-circadian-variability-by-quantum-dots-luminescent-mesoporous-silica-based-white-light-emitting-diodes
#16
Xiaobing Luo, Bin Xie, Jingjing Zhang, Wei Chen, Junjie Hao, Yanhua Cheng, Run Hu, Dan Wu, Kai Wang
Human comfortability has become one of the important criteria in the modern lighting architecture. Here, we proposed a tuning strategy to enhance the non-image forming photobiological effect on the human circadian rhythm based on the quantum dots-converted white light emitting diodes (QDs-WLEDs). We introduced the limiting variability of the circadian action factor (CAF), defined as the ratio of circadian efficiency and luminous efficiency of radiation. The CAF was deeply discussed and was found to be a function of constraining color rendering index (CRI) and correlated color temperatures (CCT)...
July 28, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28752782/the-feasibility-of-substituting-left-atrial-wall-strain-for-flow-velocity-of-left-atrial-appendage
#17
Akihito Miyoshi, Yoichi Nakamura, Yukio Kazatani, Hiroshi Ito
OBJECTIVE: Non-valvular atrial fibrillation (NVAF) is frequently complicated by thromboembolism. Left atrial appendage (LAA) flow is a predictor of LAA thrombosis. LAA flow is measured by transesophageal echocardiography (TEE), which is a semi-invasive diagnostic tool. Recently, speckle-tracking methods have been adapted for the evaluation of local cardiac function. We hypothesised that if we could determine LAA wall motion utilising a speckle tracking technique, we could non-invasively analyse LAA flow...
July 28, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28750018/pancreatic-cancer-cell-fibroblast-co-culture-induces-m2-like-macrophages-that-influence-therapeutic-response-in-a-3d-model
#18
Janina Kuen, Diana Darowski, Tobias Kluge, Meher Majety
Pancreatic cancer (PC) remains one of the most challenging solid tumors to treat with a high unmet medical need as patients poorly respond to standard-of-care-therapies. Prominent desmoplastic reaction involving cancer-associated fibroblasts (CAFs) and the immune cells in the tumor microenvironment (TME) and their cross-talk play a significant role in tumor immune escape and progression. To identify the key cellular mechanisms induce an immunosuppressive tumor microenvironment, we established 3D co-culture model with pancreatic cancer cells, CAFs and monocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28749957/delineation-of-the-role-of-chromatin-assembly-and-the-rtt101mms1-e3-ubiquitin-ligase-in-dna-damage-checkpoint-recovery-in-budding-yeast
#19
Li-Ting Diao, Chin-Chuan Chen, Briana Dennehey, Sangita Pal, Pingping Wang, Zie-Jie Shen, Angela Deem, Jessica K Tyler
The DNA damage checkpoint is activated in response to DNA double-strand breaks (DSBs). We had previously shown that chromatin assembly mediated by the histone chaperone Asf1 triggers inactivation of the DNA damage checkpoint in yeast after DSB repair, also called checkpoint recovery. Here we show that chromatin assembly factor 1 (CAF-1) also contributes to chromatin reassembly after DSB repair, explaining its role in checkpoint recovery. Towards understanding how chromatin assembly promotes checkpoint recovery, we find persistent presence of the damage sensors Ddc1 and Ddc2 after DSB repair in asf1 mutants...
2017: PloS One
https://www.readbyqxmd.com/read/28747269/high-intensity-interval-training-and-cardiac-autonomic-control-in-individuals-with-metabolic-syndrome-a-randomised-trial
#20
Joyce S Ramos, Lance C Dalleck, Fabio Borrani, Kassia S Beetham, Gregore Iven Mielke, Katrin A Dias, Matthew P Wallen, Shelley E Keating, Robert G Fassett, Jeff S Coombes
BACKGROUND: Insulin resistance has been postulated to play a central role in the co-appearance of various cardiovascular disease risk factors constituting the metabolic syndrome (MetS). There is evidence that altered cardiac autonomic function (CAF) may precede the onset of insulin resistance. Exercise training has been shown to improve CAF in different populations, yet little is known regarding the exercise dose response for CAF. The aim of this study was to investigate the impact of different volumes of high-intensity interval training (HIIT) and traditional moderate-intensity continuous training (MICT) on CAF in participants with MetS...
July 21, 2017: International Journal of Cardiology
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