keyword
MENU ▼
Read by QxMD icon Read
search

CAFs

keyword
https://www.readbyqxmd.com/read/28521725/hiv-and-syphilis-prevalence-and-associated-risks-in-the-cameroonian-armed-forces
#1
Michael Grillo, Bonnie Robin Tran, Ubald Tamoufe, Cyrille F Djoko, Karen Saylors, Kelly Woodland, Ltc Wangmene, Caroline Macera
BACKGROUND: Continued surveillance of the HIV epidemic is critical to monitor changes in trends and risk behaviors. A 2005 study in the Cameroonian Armed Forces (CAF) found an HIV prevalence of 11.3% among male and female service members. The purpose of the current study is to determine the 5-year change in the HIV prevalence, estimate the prevalence of syphilis, and examine factors associated with infection in the CAF. METHODS: Participants were male and female service members 18 years of age or older who were stationed at one of the 10 military garrisons selected for participation...
May 16, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28518141/caf-secreted-cxcl1-conferred-radioresistance-by-regulating-dna-damage-response-in-a-ros-dependent-manner-in-esophageal-squamous-cell-carcinoma
#2
Hongfang Zhang, Jing Yue, Zhenzhen Jiang, Rongjing Zhou, Ruifei Xie, Yiping Xu, Shixiu Wu
Five-year survival rate of esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy is <20%. Our study aimed to investigate whether cancer-associated fibroblasts (CAFs), one major component of tumor microenvironment, were involved in tumor radioresistance in ESCC. By use of human chemokine/cytokine array, human chemokine CXCL1 was found to be highly expressed in CAFs compared with that in matched normal fibroblasts. Inhibition of CXCL1 expression in CAFs significantly reversed CAF-conferred radioresistance in vitro and in vivo...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28517107/right-coronary-artery-coronary-sinus-fistula-with-coronary-sinus-ostium-stenosis
#3
Lihong Pu, Rongjuan Li, Ya Yang, Guowen Liu, Yueli Wang
Coronary artery fistula (CAF) is a rare anomaly of the coronary artery. The draining site of a right coronary artery (RCA) fistula may usually be the right ventricle, right atrium, or pulmonary artery. Here, we present a patient with right coronary artery to coronary sinus fistula (RCACSF) complicated by aneurysmal dilatation of the coronary sinus (CS) and stenosis of CS ostium.
May 18, 2017: Echocardiography
https://www.readbyqxmd.com/read/28515832/a-low-dose-caffeine-and-carbohydrate-supplement-does-not-improve-athletic-performance-during-volleyball-competition
#4
David R Pfeifer, Kelsey M Arvin, Courtney N Herschberger, Nicholas J Haynes, Matthew S Renfrow
Dietary supplements are widely used to enhance sport performance and the combination of carbohydrate and caffeine (CHO+CAF) has yielded particularly high performance gains. Though the effects of a CHO+CAF supplement have been studied in a laboratory environment, little research exists on the effects of supplementation during competition. Therefore, the purpose of this study was to determine the effects of a CHO+CAF supplement on athletic performance in competition. Eight female collegiate volleyball players completed three testing sessions under three different conditions separated by approximately one week each: CHO+CAF supplement, placebo (PBO), and control (CTL) using a randomized, cross-over design...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28512680/a-novel-idea-to-improve-cardiac-output-of-mechanical-circulatory-support-devices-by-optimizing-kinetic-energy-transfer-available-in-forward-moving-aortic-blood-flow
#5
Muhammad B Qureshi, Jacob Glower, Daniel L Ewert, Steven C Koenig
Mechanical circulatory support devices (MCSDs) have gained widespread clinical acceptance as an effective heart failure (HF) therapy. The concept of harnessing the kinetic energy (KE) available in the forward aortic flow (AOF) is proposed as a novel control strategy to further increase the cardiac output (CO) provided by MCSDs. A complete mathematical development of the proposed theory and its application to an example MCSDs (two-segment extra-aortic cuff) are presented. To achieve improved device performance and physiologic benefit, the example MCSD timing is regulated to maximize the forward AOF KE and minimize retrograde flow...
May 16, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28510269/kallikrein-related-peptidase-4-induces-cancer-associated-fibroblast-features-in-prostate-derived-stromal-cells
#6
T Kryza, L M Silva, N Bock, R A Fuhrman-Luck, C R Stephens, J Gao, H Samaratunga, M G Lawrence, J D Hooper, Y Dong, G P Risbridger, J A Clements
The reciprocal communication between cancer cells and their microenvironment is critical in cancer progression. Although involvement of cancer-associated fibroblasts (CAF) in cancer progression is long established, the molecular mechanisms leading to differentiation of CAFs from normal fibroblasts are poorly understood. Here, we report that kallikrein-related peptidase-4 (KLK4) promotes CAF differentiation. KLK4 is highly expressed in prostate epithelial cells of premalignant (prostatic intra-epithelial neoplasia) and malignant lesions compared to normal prostate epithelia, especially at the peri-stromal interface...
May 16, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28506698/antiproliferative-and-cytotoxic-effects-of-green-coffee-and-yerba-mate-extracts-their-main-hydroxycinnamic-acids-methylxanthine-and-metabolites-in-different-human-cell-lines
#7
M Amigo-Benavent, S Wang, R Mateos, B Sarriá, L Bravo
This work aimed at studying the effects of green coffee bean (GCBE) and yerba mate (YME) extracts, their main phenolic components (5-caffeoylquinic acid, 5-CQA; 3,5-dicaffeoylquinic acid, 3,5-DCQA) and metabolites (ferulic acid, FA; caffeic acid, CA; dihydrocaffeic acid, DHCA; and dihydroferulic acid, DHFA) along with caffeine (CAF) on the viability and proliferation of different human cell lines. Extracts (10-1000 μg/mL) and standards (10-1000 μM) were assayed in colon (Caco-2), lung (A549), oesophageal (OE-33), urinary bladder (T24) human carcinoma cells, and a non-cancer cell line (CCD-18Co)...
May 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28506312/pathomimetic-avatars-reveal-divergent-roles-of-microenvironment-in-invasive-transition-of-ductal-carcinoma-in-situ
#8
Mansoureh Sameni, Dora Cavallo-Medved, Omar E Franco, Anita Chalasani, Kyungmin Ji, Neha Aggarwal, Arulselvi Anbalagan, Xuequn Chen, Raymond R Mattingly, Simon W Hayward, Bonnie F Sloane
BACKGROUND: The breast tumor microenvironment regulates progression of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC). However, it is unclear how interactions between breast epithelial and stromal cells can drive this progression and whether there are reliable microenvironmental biomarkers to predict transition of DCIS to IDC. METHODS: We used xenograft mouse models and a 3D pathomimetic model termed mammary architecture and microenvironment engineering (MAME) to study the interplay between human breast myoepithelial cells (MEPs) and cancer-associated fibroblasts (CAFs) on DCIS progression...
May 15, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28504692/mint3-mediated-l1cam-expression-in-fibroblasts-promotes-cancer-cell-proliferation-via-integrin-%C3%AE-5%C3%AE-1-and-tumour-growth
#9
H J Nakaoka, Z Tanei, T Hara, J S Weng, A Kanamori, T Hayashi, H Sato, A Orimo, K Otsuji, K Tada, T Morikawa, T Sasaki, M Fukayama, M Seiki, Y Murakami, T Sakamoto
Fibroblasts are some of the major cells in tumour tissues that influence tumour progression and drug resistance. However, our understanding on fibroblast-mediated tumour malignancy remains incomplete. Munc18-1-interacting protein 3 (Mint3) is known as an activator of hypoxia-inducible factor-1 (HIF-1) even during normoxia in cancer cells, macrophages and fibroblasts. Although Mint3 promotes ATP production via glycolysis by activating HIF-1 in cancer cells and macrophages, the biological role of Mint3-mediated HIF-1 activation in fibroblasts remains unclear...
May 15, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28503530/caffeine-supplementation-affects-the-immunometabolic-response-to-concurrent-training
#10
Fabrício Eduardo Rossi, Valéria Leme Gonçalves Panissa, Paula Aulves Monteiro, José Gerosa-Neto, Érico Chagas Caperuto, Jason Michael Cholewa, Alessandro Moura Zagatto, Fábio Santos Lira
The aim of the present study was to investigate the effects of caffeine (CAF) and carbohydrate (CHO) intake on strength performance and its metabolic and inflammatory responses during concurrent training. Seven active males ingested a double-placebo (P), CAF (capsule 5 mg/kg) or CHO (20% maltodextrin solution) supplementation before strength exercise. Participants performed three randomized sessions of 5,000-m high-intensity intermittent aerobic exercise at maximal intensity followed by strength exercise, performing after the P, CHO, and CAF intake...
April 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28501185/simultaneous-voltammetric-determination-of-vanillin-and-caffeine-in-food-products-using-an-anodically-pretreated-boron-doped-diamond-electrode-its-comparison-with-hplc-dad
#11
Hoshyar Saadi Ali, Abdullah A Abdullah, Pınar Talay Pınar, Yavuz Yardım, Zühre Şentürk
This paper describes an electroanalytical method for the simultaneous determination of vanillin (VAN) and caffeine (CAF) using an anodically pretreated boron-doped diamond electrode. Selective determination of one compound in the presence of other one was also realized. Both compounds yielded a single irreversible oxidation peak using cyclic voltammetry. The nature of the electrode reaction was found to be diffusion controlled with contribution of adsorption. By using square-wave adsorptive stripping voltammetry after 60s accumulation under open-circuit voltage, method allowed simultaneous determination of VAN and CAF in phosphate buffer, pH 2...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28495846/dispelling-the-myth-that-habitual-caffeine-consumption-influences-the-performance-response-to-acute-caffeine-supplementation
#12
Lívia de Souza Gonçalves, Vitor de Salles Painelli, Guilherme Yamaguchi, Luana Farias de Oliveira, Bryan Saunders, Rafael Pires da Silva, Erika Maciel, Guilherme Giannini Artioli, Hamilton Roschel, Bruno Gualano
OBJECTIVE: To investigate the influence of habitual caffeine intake on exercise performance to acute caffeine supplementation. METHODS: A double-blind, crossover, counterbalanced study was performed. Forty endurance-trained cyclists were allocated into tertiles according to their daily caffeine intake: low (58 ± 29 mg(.)d(-1)), moderate (143 ± 25 mg(.)d(-1)), and high consumers (351 ± 139 mg(.)d(-1)). Participants completed three trials in which they performed simulated cycling time-trials in the fastest time possible following ingestion of: caffeine (CAF: 6 mg(...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28494747/new-diagnostic-and-therapeutic-aspects-of-pancreatic-ductal-adenocarcinoma
#13
Harald Mangge, Tobias Niedrist, Wilfried Renner, Stefan Lyer, Christoph Alexiou, Johannes Haybaeck
Pancreatic ductal adenocarcinoma (PDAC) is devastating. Because of its silent nature, the disease is often only diagnosed once it has reached an advanced, frequently inoperable stage. To date, we have no biomarkers that facilitate earlier diagnosis, leaving sufficient time for curative therapy that effectively lowers the very high mortality rate of this cancer entity. Because of this, the life expectancy of patients with PDAC is low (i.e. < 6% five-year survival rates). New data, including particular genetic signatures and features of the stromal architecture of PDAC tumors, may better explain their aggressiveness, their relatively long-lasting painless expansion, and why chemotherapy so frequently fails...
May 10, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28491158/an-unusual-cause-of-atrial-fibrillation-in-a-young-active-duty-soldier
#14
Rafik BenAbda, Anne Gunn, Eric Roberge, Ting-Wei Yang
Coronary artery fistula (CAF) is an abnormality in which the coronary artery has an anomalous connection with a venous structure such as the coronary sinus or atrium. CAF is usually congenital, but may be acquired. The prevalence in the general population is low with many asymptomatic and discovered incidentally. When symptomatic, CAF may present with dyspnea, decreasing functional capacity, and/or arrhythmia. We report a case of a young otherwise healthy active duty male with progressive symptoms of dizziness and exertional fatigue with paroxysmal atrial fibrillation...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28479374/cafeteria-diet-differentially-alters-the-expression-of-feeding-related-genes-through-dna-methylation-mechanisms-in-individual-hypothalamic-nuclei
#15
Gisela Paola Lazzarino, María Florencia Andreoli, María Florencia Rossetti, Cora Stoker, María Virgina Tschopp, Enrique Hugo Luque, Jorge Guillermo Ramos
We evaluated the effect of cafeteria diet (CAF) on the mRNA levels and DNA methylation state of feeding-related neuropeptides, and neurosteroidogenic enzymes in discrete hypothalamic nuclei. Besides, the expression of steroid hormone receptors was analyzed. Female rats fed with CAF from weaning increased their energy intake, body weight, and fat depots, but did not develop metabolic syndrome. The increase in energy intake was related to an orexigenic signal of paraventricular (PVN) and ventromedial (VMN) nuclei, given principally by upregulation of AgRP and NPY...
May 4, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28477403/micro-rna-21-regulates-cancer-associated-fibroblast-mediated-frug-resistance-in-pancreatic-cancer
#16
Lulin Zhang, Jun Yao, Wenyao Li, Ce Zhang
Pancreatic adenocarcinoma (PDAC) is one of the leading cause of cancer death due to its highly aggressive biological nature and resistance to chemotherapies. Former study also indicated that miR-21 in cancer-associated fibroblasts (CAFs) is an important regulator of their activation. However, whether miR-21 in CAFs would regulate PDAC's tumor microenvironment and leading to drug resistance remain unknown. In this study, we evaluated the relationship among CAFs activation, miR-21 expression level and drug resistance using PDAC patient tumor samples...
May 5, 2017: Oncology Research
https://www.readbyqxmd.com/read/28474772/modelling-individual-response-time-effects-between-and-within-experimental-speed-conditions-a-glmm-approach-for-speeded-tests
#17
Frank Goldhammer, Merle A Steinwascher, Ulf Kroehne, Johannes Naumann
Completing test items under multiple speed conditions avoids the performance measure being confounded with individual differences in the speed-accuracy compromise, and offers insights into the response process, that is, how response time relates to the probability of a correct response. This relation is traditionally represented by two conceptually different functions: the speed-accuracy trade-off function (SATF) across conditions relating the condition average response time to the condition average of accuracy, and the conditional accuracy function (CAF) within a condition describing accuracy conditional on response time...
May 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28474767/spontaneous-and-imposed-speed-of-cognitive-test-responses
#18
Paul De Boeck, Haiqin Chen, Mark Davison
Based on data from a cognitive test presented in a condition with time constraints per item and a condition without time constraints, the effect of speed on accuracy is investigated. First, if the effect of imposed speed on accuracy is negative it can be explained by the speed-accuracy trade-off, and if it can be captured through the corresponding latent variables, then measurement invariance applies between a condition with and a condition without time constraints. The results do show a negative effect and a lack of measurement invariance...
May 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28473208/-working-conditions-in-outpatient-clinics-adjacent-to-private-pharmacies-in-mexico-city-perspective-of-physicians
#19
Sandra P Díaz-Portillo, Hortensia Reyes-Morales, Silvia Magali Cuadra-Hernández, Álvaro J Idrovo, Gustavo Nigenda, Anahí Dreser
OBJECTIVE: To analyse the working conditions of physicians in outpatient clinics adjacent to pharmacies (CAFs) and their organizational elements from their own perspective. METHODS: We carried out an exploratory qualitative study. Semi-structured interviews were conducted with 32 CAF physicians in Mexico City. A directed content analysis technique was used based on previously built and emerging codes which were related to the experience of the subjects in their work...
May 1, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28471108/dna-methylation-in-the-tumor-microenvironment
#20
Meng-Wen Zhang, Kenji Fujiwara, Xu Che, Shu Zheng, Lei Zheng
The tumor microenvironment (TME) plays an important role in supporting cancer progression. The TME is composed of tumor cells, the surrounding tumor-associated stromal cells, and the extracellular matrix (ECM). Crosstalk between the TME components contributes to tumorigenesis. Recently, one of our studies showed that pancreatic ductal adenocarcinoma (PDAC) cells can induce DNA methylation in cancer-associated fibroblasts (CAFs), thereby modifying tumor-stromal interactions in the TME, and subsequently creating a TME that supports tumor growth...
May 2017: Journal of Zhejiang University. Science. B
keyword
keyword
16318
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"