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https://www.readbyqxmd.com/read/29778708/fluorescence-resonance-energy-transfer-of-caf-2-eu-2-tb-3-applied-to-dye-sensitized-solar-cells
#1
Lege Wang, Zijian Yang, You-Fen Li, Ru Yang, Zhigang Dai, Shuqiao Hu, Liangliang Sun, Yaoyao Tong
CaF2 : Eu2+ , Tb3+ introduced into dye-sensitized solar cells (DSSCs) were studied to examine the influence of luminescent materials on photoanodes using a simple method. The emission spectra of CaF2 : Eu2+ , Tb3+ included the blue light of Eu2+ (4f → 5d) at 430 nm and green emission of Tb3+ (5 D4  → 7 F5 ) at 542 nm under the monitoring wavelengths at 398 nm, which matched well the absorption range of the N719 dye in DSSCs. Energy transfer (ET) was verified between Eu2+ and Tb3+ ions and the efficiency of ET found to increase with Tb3+ concentration...
May 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29777632/predictor-factors-for-long-term-outcomes-stability-of-coronally-advanced-flap-with-or-without-connective-tissue-graft-in-the-treatment-of-single-maxillary-gingival-recessions-9-years-results-of-a-randomised-controlled-clinical-trial
#2
Giulio Rasperini, Raffaele Acunzo, Gaia Pellegrini, Giorgio Pagni, Maurizio Tonetti, Giovan Paolo Pini Prato, Pierpaolo Cortellini
AIM: To assess the clinical outcomes 9 years after the surgical treatment of single maxillary gingival recessions and identify predictors for long-term gingival margin stability. MATERIALS AND METHODS: Twenty-five gingival recession (Miller Class I and II) were randomly treated with CAF plus CTG or CAF alone. Outcomes included Complete Root Coverage (CRC), Recession Reduction (REC), Keratinized Tissue (KT) gain and dentin hypersensitivity, and were evaluated at 6-month, 1-year and 9-year...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29769769/evaluation-of-periosteum-eversion-and-coronally-advanced-flap-techniques-in-the-treatment-of-isolated-miller-s-class-i-ii-gingival-recession-a-comparative-clinical-study
#3
Koel Debnath, Anirban Chatterjee
Aim: The present investigation aimed to evaluate root coverage (RC) with periosteum eversion technique (PET) using periosteum as a graft and coronally advanced flap (CAF) with platelet-rich fibrin (PRF) membrane as a graft in the treatment of isolated Miller's class I and II gingival recession defects. Materials and Methods: Thirty sites in 15 participants with Miller's Class I or II gingival recession were randomly treated either with PET using periosteum as graft and CAF + PRF as graft...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29769197/cancer-associated-fibroblasts-drive-glycolysis-in-a-targetable-signaling-loop-implicated-in-head-and-neck-squamous-cell-carcinoma-progression
#4
Dhruv Kumar, Jacob New, Vikalp Vishwakarma, Radhika Joshi, Jonathan Enders, Fangchen Lin, Sumana Dasari, Wade R Gutierrez, George Leef, Sivapriya Ponnurangam, Hemantkumar Chavan, Lydia Ganaden, Mackenzie M Thornton, Hongying Dai, Ossama Tawfik, Jeffrey Straub, Yelizaveta Shnayder, Kiran Kakarala, Terance Ted Tsue, Douglas A Girod, Bennett Van Houten, Shrikant Anant, Partha Krishnamurthy, Sufi Mary Thomas
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously reported that CAF-secreted hepatocyte growth factor (HGF) facilitates HNSCC progression, however very little is known about the role of CAFs in HNSCC metabolism. Here we demonstrate that CAF-secreted HGF increases extracellular lactate levels in HNSCC via upregulation of glycolysis...
May 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29768524/evaluation-of-the-effect-of-dose-dependent-platelet-rich-fibrin-membrane-on-treatment-of-gingival-recession-a-randomized-controlled-clinical-trial
#5
Rana Culhaoglu, Levent Taner, Berceste Guler
Miller's class I gingival recessions (GR) have been treated using coronally advanced flap (CAF) with platelet-rich fibrin membrane (PRF membrane) or connective tissue graft (CTG). The aim of this study was to evaluate the effect of different multiple layers of PRF membranes for the treatment of GR compared with the CTG procedure. Sixty-three Miller class I GR were treated in this study. Twenty-one GR selected randomly were treated with two layers of PRF membranes+CAF in 2PRF+CAF (test group-1), four layers of PRF membranes+CAF in 4PRF+CAF (test group-2), and CTG+CAF in the control group...
May 14, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29764866/lrrc15-is-a-novel-mesenchymal-protein-and-stromal-target-for-antibody-drug-conjugates
#6
James W Purcell, Sonia G Tanlimco, Jonathan A Hickson, Melvin Fox, Mien Sho, Lisa Durkin, Tamar Uziel, Rick Powers, Kelly D Foster-Duke, Thomas McGonigal, Subashri Kumar, Josue Samayoa, Dong Zhang, Joann P Palma, Sasmita Mishra, Diane Hollenbaugh, Kurt Gish, Susan E Morgan-Lappe, Eric D Hsi, Debra T Chao
Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell type-specific protein markers. Using RNA expression profiling, we identified the membrane protein leucine rich repeat containing 15 (LRRC15) as highly expressed in multiple solid tumor indications with limited normal tissue expression. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e...
May 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29763642/a-new-insight-into-the-oxidative-mechanism-of-caffeine-and-related-methylxanthines-in-aprotic-medium-may-caffeine-be-really-considered-as-an-antioxidant
#7
Rita Petrucci, Giuseppe Zollo, Antonella Curulli, Giancarlo Marrosu
BACKGROUND: Antioxidant properties have been recently suggested for caffeine that seems showing protective effects against damages caused by oxidative stress. In particular, a HO scavenging activity has been ascribed to caffeine. Even if the oxidation of caffeine has been widely studied, the antioxidant mechanism is still far to be understood. METHODS: The electrochemical behavior of caffeine, theobromine and theophylline was studied in aprotic medium by cyclic voltammetry and electrolysis in UV-vis cell; a computational analysis of the molecular structures based on the Density Functional Theory was performed; the reactivity of all substrates towards lead dioxide, superoxide and galvinoxyl radical was followed by UV-vis spectrophotometry...
May 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29762607/efficient-continuous-wave-and-passive-q-switched-mode-locked-er-3-caf-2-srf-2-lasers-in-the-mid-infrared-region
#8
Jingjing Liu, Xiaoyue Feng, Xiuwei Fan, Zhen Zhang, Bo Zhang, Jie Liu, Liangbi Su
An Er3+ -doped CaF2 -SrF2 mixed crystal was grown using the temperature gradient technique, and its laser characteristics were studied. In a compact linear cavity, a continuous-wave output power of 712 mW was obtained with the highest slope efficiency of 41.4%. Using a semiconductor saturable absorber mirror, a passive Q-switched mode-locked Er3+ :CaF2 -SrF2 laser emitting at 2729.5 nm was demonstrated for the first time, to the best of our knowledge. The maximum average output power of 125 mW was obtained at an absorbed pump power of 1...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29761750/obesity-disrupts-rhythmic-clock-gene-expression-in-maternal-adipose-tissue-during-rat-pregnancy
#9
Rachael C Crew, Peter J Mark, Brendan J Waddell
Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock also undergoes major change as part of the maternal metabolic adaptation to pregnancy, but whether this is affected by maternal obesity is unknown. Consequently, in this study we tested the hypothesis that obesity disturbs rhythmic gene expression in maternal adipose tissue across pregnancy...
June 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29761502/efficacy-of-tunnel-technique-in-the-treatment-of-localized-and-multiple-gingival-recessions-a-systematic-review-and-a-meta-analysis
#10
REVIEW
Lorenzo Tavelli, Shayan Barootchi, Trang V N Nguyen, Mustafa Tattan, Andrea Ravidà, Hom-Lay Wang
BACKGROUND: Tunnel technique (TUN) has recently gained popularity among clinicians for its promising clinical and esthetic results when treating gingival recessions (GRs) defects. However, the evidence of the efficacy of TUN in the literature is still to be determined. Therefore, the aim of the present systematic review and meta-analysis was to investigate the predictability of TUN and its comparison to coronally advanced flap (CAF) procedure. MATERIAL AND METHODS: A literature search on PubMed, Cochrane libraries, EMBASE, and hand-searched journals until November 2017 was conducted to identify clinical studies investigating TUN for root coverage procedures...
May 14, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29760737/injection-laryngoplasty-using-autologous-fat-enriched-with-adipose-derived-regenerative-stem-cells-a-safe-therapeutic-option-for-the-functional-reconstruction-of-the-glottal-gap-after-unilateral-vocal-fold-paralysis
#11
José M Lasso, Daniel Poletti, Batolomé Scola, Pedro Gómez-Vilda, Ana I García-Martín, María Eugenia Fernández-Santos
Background: Paralysis of one vocal fold leads to glottal gap and vocal fold insufficiency that has significant impact upon a patient's quality of life. Fillers have been tested to perform intracordal injections, but they do not provide perdurable results. Early data suggest that enriching fat grafts with adipose-derived regenerative cells (ADRCs) promote angiogenesis and modulate the immune response, improving graft survival. The aim of this study is to propose ADRC-enriched adipose tissue grafts as effective filler for the paralyzed vocal fold to use it for functional reconstruction of the glottal gap...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29760705/induction-of-cytotoxic-t-lymphocyte-responses-upon-subcutaneous-administration-of-a-subunit-vaccine-adjuvanted-with-an-emulsion-containing-the-toll-like-receptor-3-ligand-poly-i-c
#12
Signe Tandrup Schmidt, Gabriel Kristian Pedersen, Malene Aaby Neustrup, Karen Smith Korsholm, Thomas Rades, Peter Andersen, Camilla Foged, Dennis Christensen
There is an unmet medical need for new subunit vaccines that induce cytotoxic T-lymphocyte (CTL) responses to prevent infection with a number of pathogens. However, stimulation of CTL responses via clinically acceptable subcutaneous (s.c.) and intramuscular (i.m.) injection is challenging. Recently, we designed a liposomal adjuvant [cationic adjuvant formulation (CAF)09] composed of the cationic lipid dimethyldioctadecylammonium (DDA) bromide, a synthetic monomycoloyl glycerol analog and polyinosinic:polycytidylic acid, which induce strong CTL responses to peptide and protein antigens after intraperitoneal administration...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29760045/gfpt2-expressing-cancer-associated-fibroblasts-mediate-metabolic-reprogramming-in-human-lung-adenocarcinoma
#13
Weiruo Zhang, Gina Bouchard, Alice Yu, Majid Shafiq, Mehran Jamali, Joseph B Shrager, Kelsey Ayers, Shaimaa Bakr, Andrew J Gentles, Maximilian Diehn, Andrew Quon, Robert B West, Viswam Nair, Matt van de Rijn, Sandy Napel, Sylvia K Plevritis
Metabolic reprogramming of the tumor microenvironment is recognized as a cancer hallmark. To identify new molecular processes associated with tumor metabolism, we analyzed the transcriptome of bulk and flow-sorted human primary non-small cell lung cancer (NSCLC) together with 18FDG-positron emission tomography scans, which provide a clinical measure of glucose uptake. Tumors with higher glucose uptake were functionally enriched for molecular processes associated with invasion in adenocarcinoma (AD) and cell growth in squamous cell carcinoma (SCC)...
May 14, 2018: Cancer Research
https://www.readbyqxmd.com/read/29756945/magnetic-trapping-and-coherent-control-of-laser-cooled-molecules
#14
H J Williams, L Caldwell, N J Fitch, S Truppe, J Rodewald, E A Hinds, B E Sauer, M R Tarbutt
We demonstrate coherent microwave control of the rotational, hyperfine, and Zeeman states of ultracold CaF molecules, and the magnetic trapping of these molecules in a single, selectable quantum state. We trap about 5×10^{3} molecules for almost 2 s at a temperature of 70(8)  μK and a density of 1.2×10^{5}  cm^{-3}. We measure the state-specific loss rate due to collisions with background helium.
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29756328/serum-derived-carcinoembryonic-antigen-cea-activates-fibroblasts-to-induce-a-local-re-modeling-of-the-extracellular-matrix-that-favors-the-engraftment-of-cea-expressing-tumor-cells
#15
Aws Abdul-Wahid, Marzena Cydzik, Nicholas W Fischer, Aaron Prodeus, John E Shively, Anne Martel, Samira Alminawi, Zeina Ghorab, Neil L Berinstein, Jean Gariépy
Elevated levels of the carcinoembryonic antigen (CEA; CEACAM5) in the serum of colorectal cancer (CRC) patients represent a clinical biomarker that correlates with disease recurrence. However, a mechanistic role for soluble CEA (sCEA) in tumor progression and metastasis remains to be established. In this study, we report that sCEA acts as a paracrine factor, activating human fibroblasts by signalling through both the STAT3 and AKT1-mTORC1 pathways, promoting their transition to a cancer-associated fibroblast (CaF) phenotype...
May 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29755910/coronary-artery-fistula-causing-acute-myocardial-infarction-and-right-ventricle-thrombus
#16
Eduardo L Santos, Milena M Gouveia, Ricardo F Silva, Renata Ávila, Maria A Aquino, Luca T Dompieri, Renato D Lopes
Coronary artery fistula (CAF) is a rare congenital anomaly, which is most commonly asymptomatic. In symptomatic cases, aneurysms can occur with complications of thromboembolic events. This report describes a rare case of CAF presenting with complications of inferior acute myocardial infarction and thrombus formation in the right ventricle.
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29751847/asf1-is-required-to-load-histones-on-the-hira-complex-in-preparation-of-paternal-chromatin-assembly-at-fertilization
#17
Béatrice Horard, Laure Sapey-Triomphe, Emilie Bonnefoy, Benjamin Loppin
BACKGROUND: Anti-Silencing Factor 1 (ASF1) is a conserved H3-H4 histone chaperone involved in both Replication-Coupled and Replication-Independent (RI) nucleosome assembly pathways. At DNA replication forks, ASF1 plays an important role in regulating the supply of H3.1/2 and H4 to the CAF-1 chromatin assembly complex. ASF1 also provides H3.3-H4 dimers to HIRA and DAXX chaperones for RI nucleosome assembly. The early Drosophila embryo is an attractive system to study chromatin assembly in a developmental context...
May 11, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29751106/curcumin-exerts-its-antitumor-effects-in-a-context-dependent-fashion
#18
Dominique Kreutz, Chomdao Sinthuvanich, Andrea Bileck, Lukas Janker, Besnik Muqaku, Astrid Slany, Christopher Gerner
Proteome profiling profoundly contributes to the understanding of cell response mechanisms to drug actions. Such knowledge may become a key to improve personalized medicine. In the present study, the effects of the natural remedy curcumin on breast cancer model systems were investigated. MCF-7, ZR-75-1 and TGF-β1 pretreated fibroblasts, mimicking cancer-associated fibroblasts (CAFs), were treated independently as well as in tumor cell/CAF co-cultures. Remarkably, co-culturing with CAF-like cells (CLCs) induced different proteome alterations in MCF-7 and ZR-75-1 cells, respectively...
May 8, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29738355/morning-blood-pressure-surge-is-associated-independently-with-orthostatic-hypotension-in-hypertensive-patients-under-treatment
#19
Hakan Caf, Yurdaer Dönmez, Emel Çeliker Güler, Onur Kaypakli, Yahya Kemal İçen, Mevlüt Koç
OBJECTIVE: Morning blood pressure surge (MBPS) and orthostatic hypotension (OH) play a role in the occurrence of cardiovascular events. We aimed to investigate the association between MBPS and OH in hypertensive patients under treatment. PATIENTS AND METHODS: We prospectively included 297 patients (mean age: 53.8±10.7 years, male/female: 101/196) with essential hypertension. Tilt table testing was performed for the diagnosis of OH. OH was classified into three groups as initial OH (0-15 s), classical OH (15 s to 3 min), and delayed OH (3-30 min)...
May 7, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29738282/caffeine-ingestion-changes-time-motion-and-technical-tactical-aspects-in-simulated-boxing-matches-a-randomized-double-blind-pla-controlled-crossover-study
#20
Victor Silveira Coswig, Paulo Gentil, Francine Irigon, Fabrício Boscolo Del Vecchio
The number of offensive actions and glycolytic energy in combat sports both increase with caffeine (CAF) ingestion. In addition, the effects of CAF on technical-tactical and time-motion analysis and physiological parameters in boxing are unknown. This study aimed to investigate the effects of CAF ingestion on physiological parameters and the notational analysis of boxing matches. Ten male boxers were recruited; the participants ingested 6 mg kg-1 BM of CAF or placebo (PLA) 30 min prior to the match in a crossover design...
May 8, 2018: European Journal of Sport Science
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