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https://www.readbyqxmd.com/read/30285099/neoatherosclerosis-after-drug-eluting-stent-implantation-a-novel-clinical-and-therapeutic-challenge
#1
Josip A Borovac, Domenico D'Amario, Rocco Vergallo, Italo Porto, Antonio Bisignani, Mattia Galli, Gianmarco Annibali, Rocco A Montone, Antonio Maria Leone, Giampaolo Niccoli, Filippo Crea
The recognition that obstructive disease of the epicardial coronary arteries, causing ischemic heart disease, can be treated with a percutaneous coronary intervention (PCI) has been a major discovery in cardiology in the last 40 years contributing, in particular, to the reduction of mortality associated to acute myocardial infarction (AMI). However, even in the era of drug-eluting stent (DES) implantation, a sizable proportion of patients who undergo PCI may develop late or very late post-implantation complications, that occur in the form of restenosis, neoatherosclerosis and/or in-stent thrombosis...
October 4, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29968090/drug-distribution-and-basic-pharmacology-of-paclitaxel-resveratrol-coated-balloon-catheters
#2
Ulrich Speck, Akvile Häckel, Eyk Schellenberger, Stefanie Kamann, Melanie Löchel, Yvonne P Clever, Daniel Peters, Bruno Scheller, Sabrina Trog, Stephanie Bettink
PURPOSE: To experimentally investigate a new homogenously paclitaxel/resveratrol-coated balloon catheter in terms of transport of the coating to the treated tissue and local effects including histology and functional tests. METHODS: Adherence of the coating to the balloon was explored by in vitro simulation of its passage to the lesion. Paclitaxel and resveratrol transfer to the vessel wall was investigated in porcine coronary and peripheral arteries. Matrix-assisted laser desorption/ionization (MALDI) was used for direct microscopic visualization of paclitaxel in arterial tissue...
October 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29803340/role-of-oxidative-stress-in-the-process-of-vascular-remodeling-following-coronary-revascularization
#3
Giovanna Gallo, Giorgia Pierelli, Maurizio Forte, Roberta Coluccia, Massimo Volpe, Speranza Rubattu
Percutaneous coronary interventions (PCI), including balloon angioplasty and implantation of both bare metal and drug eluting coronary stents, are associated with risk of restenosis and in-stent thrombosis. A better understanding of signals that regulate cellular proliferation, neointimal formation and vessel wall thickening following PCI may contribute to identify novel preventive and therapeutic strategies aimed to reduce the atherosclerosis progression and the consequent vascular sequelae. Among the possible mechanisms, an increased level of reactive oxygen species (ROS) is associated with endothelial dysfunction and vascular smooth muscle cells (VSMCs) proliferation and migration involved in the post-procedural remodeling process...
October 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29775572/gene-therapy-with-antisense-oligonucleotides-silencing-c-myc-reduces-neointima-formation-and-vessel-wall-thickness-in-a-mouse-model-of-vein-graft-disease
#4
Christina Maria Steger, Nikolaos Bonaros, Ralf Joachim Rieker, Johannes Bonatti, Thomas Schachner
Gene therapy for avoiding intimal hyperplasia of vein grafts after coronary artery bypass grafting is still discussed controversially. A promising application of gene therapy in vein grafts is the use of antisense oligonucleotides to block the expression of genes encoding cell cycle regulatory proteins in vascular smooth muscle cells. C-myc, either directly or by regulating the expression of other proteins, controls cell proliferation, apoptosis and cell survival, tissue remodeling, angiogenesis, cell metabolism, production of inflammatory and anti-inflammatory cytokines, and also participates in cell transformation...
August 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29770610/arsenic-trioxide-coated-stent-is-an-endothelium-friendly-drug-eluting-stent
#5
Yinping Zhao, Ruolin Du, Tian Zhou, Dongchuan Yang, Yuhua Huang, Yi Wang, Junli Huang, Xiaoyi Ma, Fugui He, Juhui Qiu, Guixue Wang
An ideal vascular stent would both inhibit in-stent restenosis (ISR) and promote rapid re-endothelialization. In the current study, the performance of arsenic trioxide (ATO)-drug eluting stent (AES) is compared with the bare metal stent, poly-lactic-co-glycolic acid-coating metal stent, and rapamycin-drug eluting stent (RES). In vivo AES is shown to prevent neointimal hyperplasia more efficiently than the others when implanted into the carotid arteries of rabbits. Moreover, AES promotes endothelial cells proliferation and re-endothelialization more quickly than RES...
August 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29765072/notoginsenoside-r1-inhibits-vascular-smooth-muscle-cell-proliferation-migration-and-neointimal-hyperplasia-through-pi3k-akt-signaling
#6
Haihong Fang, Shilin Yang, Yingying Luo, Cheng Zhang, Yi Rao, Renjing Liu, Yulin Feng, Jun Yu
Restenosis caused by neointimal hyperplasia significantly decreases long-term efficacy of percutaneous transluminal angioplasty (PTA), stenting, and by-pass surgery for managing coronary and peripheral arterial diseases. A major cause of pathological neointima formation is abnormal vascular smooth muscle cell (VSMC) proliferation and migration. Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng and has reported cardioprotective, neuroprotective and anti-inflammatory effects...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29606869/propylthiouracil-coated-biodegradable-polymer-inhibited-neointimal-formation-and-enhanced-re-endothelialization-after-vascular-injury
#7
Shang-Hung Chang, Cheng-Hung Lee, Yung-Hsin Yeh, Shih-Jung Liu, Chao-Jan Wang, Ming-Yi Hsu, Wei-Jan Chen
Background: The drug-eluting stent is a standard approach for the treatment of coronary artery disease. Propylthiouracil (PTU), an antithyroid drug, has been proven to suppress neointimal formation after balloon injury. Materials and methods: This study used a biodegradable polymer coating with PTU to test its effects on platelet function, re-endothelialization, and neointimal formation after vascular injury. Electrospinning was used to fabricate hybrid stents and generate PTU-loaded nanofibers...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29599139/protective-role-of-mpges-1-microsomal-prostaglandin-e-synthase-1-derived-pge-2-prostaglandin-e-2-and-the-endothelial-ep4-prostaglandin-e-receptor-in-vascular-responses-to-injury
#8
Huifeng Hao, Sheng Hu, Qing Wan, Chuansheng Xu, Hong Chen, Liyuan Zhu, Zhenyu Xu, Jian Meng, Richard M Breyer, Nailin Li, De-Pei Liu, Garret A FitzGerald, Miao Wang
OBJECTIVE: Deletion of mPGES-1 (microsomal prostaglandin E synthase-1)-an anti-inflammatory target alternative to COX (cyclooxygenase)-2-attenuates injury-induced neointima formation in mice. This is attributable to the augmented levels of PGI2 (prostacyclin)-a known restraint of the vascular response to injury, acting via IP (I prostanoid receptor). To examine the role of mPGES-1-derived PGE2 (prostaglandin E2 ) in vascular remodeling without the IP. APPROACH AND RESULTS: Mice deficient in both IP and mPGES-1 (DKO [double knockout] and littermate controls [IP KO (knockout)]) were subjected to angioplasty wire injury...
May 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29521477/serial-intravascular-ultrasound-evaluation-of-the-desolve%C3%A2-novolimus-eluting-bioresorbable-coronary-scaffold-system
#9
Gentil Barreira, J Ribamar Costa, Ricardo Costa, Rodolfo Staico, Daniel Chamie, Juliano R Slhessarenko, Luiz Fernando Tanajura, Andrea Abizaid, Amanda Sousa, Alexandre Abizaid
INTRODUCTION: Bioresorbable coronary scaffolds (BRS) have been developed to increase the late safety of coronary angioplasty by providing transitory coronary support and then being fully incorporated to the vessel wall. In the present trial, we sought to evaluate the performance and changes over time in the DESolve™ novolimus-eluting BRS using serial intravascular ultrasound (IVUS) in patients submitted to percutaneous coronary interventions. METHODS: Single-center, prospective, non-randomized study involving 17 consecutive patients submitted to implantation of the DESolve™ scaffold and serial evaluated with IVUS at different time points (post procedure, 6 and 18 months)...
March 9, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29477204/microrna-155-promotes-neointimal-hyperplasia-through-smooth-muscle-like-cell-derived-rantes-in-arteriovenous-fistulas
#10
Ke Wang, Peng Deng, Yuan Sun, Ping Ye, Anchen Zhang, Chuangyan Wu, Zhang Yue, Zhaolei Chen, Jiahong Xia
OBJECTIVE: Arteriovenous fistula (AVF) suffers from a high number of failures caused by insufficient outward remodeling and venous neointimal hyperplasia formation. The aim was to investigate the exact mechanism by which microRNA-155 (miR-155) in the outflow vein of AVF is regulated. METHODS: AVFs between the branch of the jugular vein and carotid artery in an end-to-end manner were created in C57BL/6 and miR-155-/- mice with a C57BL/6 background. The venous segments were harvested at day 7, 14, 21, and 28, and the AVFs were analyzed histologically and at a messenger RNA level using real-time quantitative polymerase chain reactions...
March 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29349698/third-generation-dual-source-ct-enables-accurate-diagnosis-of-coronary-restenosis-in-all-size-stents-with-low-radiation-dose-and-preserved-image-quality
#11
Yuehua Li, Mengmeng Yu, Wenbin Li, Zhigang Lu, Meng Wei, Jiayin Zhang
OBJECTIVES: To investigate the diagnostic performance of low dose stent imaging in patients with large (≥ 3 mm) and small (< 3 mm) calibre stents by third-generation dual-source CT. METHODS: Symptomatic patients suspected of having in-stent restenosis (ISR) were prospectively enrolled. Coronary computed tomography angiography (CCTA) and invasive coronary angiography (ICA) were performed within 1 month for correlation. Binary ISR was defined as an in-stent neointimal proliferation with diameter stenosis ≥ 50%...
June 2018: European Radiology
https://www.readbyqxmd.com/read/29335599/hindlimb-ischemia-impairs-endothelial-recovery-and-increases-neointimal-proliferation-in-the-carotid-artery
#12
Sabato Sorrentino, Claudio Iaconetti, Salvatore De Rosa, Alberto Polimeni, Jolanda Sabatino, Clarice Gareri, Francesco Passafaro, Teresa Mancuso, Laura Tammè, Chiara Mignogna, Caterina Camastra, Giovanni Esposito, Antonio Curcio, Daniele Torella, Ciro Indolfi
Peripheral ischemia is associated with higher degree of endothelial dysfunction and a worse prognosis after percutaneous coronary interventions (PCI). However, the role of peripheral ischemia on vascular remodeling in remote districts remains poorly understood. Here we show that the presence of hindlimb ischemia significantly enhances neointima formation and impairs endothelial recovery in balloon-injured carotid arteries. Endothelial-derived microRNAs are involved in the modulation of these processes. Indeed, endothelial miR-16 is remarkably upregulated after vascular injury in the presences of hindlimb ischemia and exerts a negative effect on endothelial repair through the inhibition of RhoGDIα and nitric oxide (NO) production...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29304538/catestatin-prevents-macrophage-driven-atherosclerosis-but-not-arterial-injury-induced-neointimal-hyperplasia
#13
Miho Kojima, Nana Ozawa, Yusaku Mori, Yui Takahashi, Kaho Watanabe-Kominato, Remina Shirai, Rena Watanabe, Kengo Sato, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Shinji Koba, Youichi Kobayashi, Tsutomu Hirano, Takuya Watanabe
Catestatin, a catecholamine-release inhibitory peptide, has multiple cardiovascular activities. Conflicting results have been recently reported by increased or decreased plasma levels of catestatin in patients with coronary artery disease (CAD). However, there have been no previous reports regarding the effects of catestatin on arteriosclerosis. This study evaluated the vasoprotective effects of catestatin on human macrophages, human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs) in vitro, and aortic atherosclerosis and wire injury-induced femoral artery neointimal hyperplasia in apolipoprotein E-deficient (ApoE-/- ) mice fed with a high-cholesterol diet...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29290989/upregulation-of-mir-126-3p-promotes-human-saphenous-vein-endothelial-cell-proliferation-in-vitro-and-prevents-vein-graft-neointimal-formation-ex-vivo-and-in-vivo
#14
Qingxi Qu, Weidong Bing, Xiangbin Meng, Jie Xi, Xiao Bai, Qing Liu, Yaqiu Guo, Xin Zhao, Yanwen Bi
Poor long-term patency of vein grafts remains an obstacle in coronary artery bypass grafting (CABG) surgery using an autologous saphenous vein graft. Recent studies have revealed that miR-126-3p promotes vascular integrity and angiogenesis. We aimed to identify the role of miR-126-3p in the setting of vein graft disease and investigate the value of miR-126-3p agomir as a future gene therapy in vein graft failure. Expression analysis of circulating miR-126-3p in plasma from CABG patients established the basic clues that miR-126-3p participates in CABG...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29185213/carotid-artery-ligation-induced-intimal-thickening-and-proliferation-is-unaffected-by-ageing
#15
B A Brown, H Williams, A R Bond, G D Angelini, J L Johnson, S J George
Following interventions to treat atherosclerosis, such as coronary artery bypass graft surgery, restenosis occurs in approximately 40% of patients. Identification of proteins regulating intimal thickening could represent targets to prevent restenosis. Our group previously demonstrated that in a murine model of vascular occlusion, Wnt4 protein expression and β-catenin signalling was upregulated which promoted vascular smooth muscle cell (VSMC) proliferation and intimal thickening. In this study, the effect of age on VSMC proliferation, intimal hyperplasia and Wnt4 expression was investigated...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29080545/increased-serum-trem-1-level-is-associated-with-in-stent-restenosis-and-activation-of-trem-1-promotes-inflammation-proliferation-and-migration-in-vascular-smooth-muscle-cells
#16
Fang Wang, Chang Li, Feng Hua Ding, Ying Shen, Jie Gao, Zhu Hui Liu, Jia Wei Chen, Rui Yan Zhang, Wei Feng Shen, Xiao Qun Wang, Lin Lu
BACKGROUND AND AIMS: In-stent restenosis (ISR) remains a major limitation of percutaneous coronary intervention despite improvements in stent design and pharmacological agents, whereas the mechanism of ISR has not been fully clarified. In the present study, we sought to investigate the potential association of serum soluble TREM-1 (sTREM-1) levels with the incidence of ISR. The role of TREM-1 was evaluated in cultured vascular smooth muscle cells (VSMCs). METHODS: Out of 1683 patients undergoing coronary intervention and follow-up coronary angiography after approximately one year, 130 patients were diagnosed with ISR, and 150 gender- and age-matched patients with no ISR were randomly included as controls...
December 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29080150/in-stent-fractional-flow-reserve-variations-and-related-optical-coherence-tomography-findings-the-ffr-oct-co-registration-study
#17
Stylianos A Pyxaras, Tom Adriaenssens, Emanuele Barbato, Giovanni Jacopo Ughi, Luigi Di Serafino, Frederic De Vroey, Gabor Toth, Shengxian Tu, Johan H C Reiber, Jeroen J Bax, William Wijns
We sought to assess in-stent variations in fractional flow reserve (FFR) in patients with previous percutaneous coronary intervention (PCI) and to associate any drop in FFR with findings by optical coherence tomography (OCT) imaging. Suboptimal post-PCI FFR values were previously associated with poor outcomes. It is not known to which extent in-stent pressure loss contributes to reduced FFR. In this single-arm observational study, 26 patients who previously underwent PCI with drug-eluting stent or scaffold implantation were enrolled...
April 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28932353/diagnosis-and-management-challenges-of-in-stent-restenosis-in-coronary-arteries
#18
REVIEW
M Chadi Alraies, Fahed Darmoch, Ramyashree Tummala, Ron Waksman
Over the course of the 3 decades, percutaneous coronary intervention (PCI) with stent implantation transformed the practice of cardiology. PCI with stenting is currently the most widely performed procedure for the treatment of symptomatic coronary disease. In large trials, drug-eluting stents (DES) have led to a significant reduction in in-stent restenosis (ISR) rates, one of the major limitations of bare-metal stents. Due to these favorable findings, DES was rapidly and widely adopted enabling more complex coronary interventions...
August 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28902718/effect-of-drug-coated-balloon-on-stent-restenosis-neointimal-proliferation-and-coronary-dissection-an-optical-coherence-tomography-analysis
#19
Taku Fukushima, Takashi Ashikaga, Shunji Yoshikawa, Yu Hatano, Daisuke Ueshima, Takanobu Yamamoto, Maejima Yasuhiro, Mitsuaki Isobe
AIM: The aim of this study was to assess the acute and mid-term effects of drug-coated balloon (DCB) in terms of the healing process of non-flow-limiting dissections and changes in the neointimal area after DCB treatment using frequency domain optical coherence tomography (FD-OCT). PATIENTS AND METHODS: Thirty-six consecutive patients with in-stent restenosis pretreated with a scoring balloon were evaluated (19 and 17 patients with and without a DCB, respectively)...
January 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/28841817/plasma-osteopontin-concentration-is-elevated-in-patients-with-coronary-bare-metal-stent-restenosis
#20
Kerem Can Yilmaz, Ugur Abbas Bal, Emir Karacaglar, Kaan Okyay, Alp Aydinalp, Aylin Yildirir, Haldun Muderrisoglu
OBJECTIVE: Osteopontin is a component of atherosclerotic lesions, secreted by monocytes, macrophages and endothelial and vascular smooth muscle cells, which together are responsible for neointimal proliferation. We examined whether elevated plasma osteopontin concentration was associated with in-stent restenosis in patients with coronary artery disease. SUBJECTS AND METHODS: We enrolled 91 patients who underwent coronary artery stenting, and 60 control patients with normal findings on coronary angiography, between June 2012 and September 2013...
February 2018: Acta Cardiologica
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