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neointimal proliferation

Kelly Wun, Betty R Theriault, Joseph F Pierre, Edmund B Chen, Vanessa A Leone, Katharine G Harris, Liqun Xiong, Qun Jiang, Melanie Spedale, Owen M Eskandari, Eugene B Chang, Karen J Ho
BACKGROUND: The microbiome has a functional role in a number of inflammatory processes and disease states. While neointimal hyperplasia development has been linked to inflammation, a direct role of the microbiota in neointimal hyperplasia has not yet been established. Germ-free (GF) mice are an invaluable model for studying causative links between commensal organisms and the host. We hypothesized that GF mice would exhibit altered neointimal hyperplasia following carotid ligation compared to conventionally raised (CONV-R) mice...
2018: PloS One
Yoshihisa Makino, Takuya Miyahara, Jun Nitta, Kazuhiro Miyahara, Akihiko Seo, Masaru Kimura, Masamitsu Suhara, Atsushi Akai, Daisuke Akagi, Kota Yamamoto, Katsuyuki Hoshina
BACKGROUND: Specialized proresolving mediators from ω-3 polyunsaturated fatty acid may control resolution of inflammation. We evaluated the influence of two specialized proresolving mediators, resolvin D1 (RvD1) and protectin D1 isomer (PD1 iso) on neointimal hyperplasia after balloon injury. MATERIALS AND METHODS: Sprague Dawley male rats at 12-14 wk of age were injured as a model of balloon angioplasty. Then, 1 μg/rat of RvD1 or PD1 iso was administered intravenously via the tail vein immediately and 2 d after angioplasty...
January 2019: Journal of Surgical Research
Dongqing Wang, Bin Gao, Jianing Yue, Fei Liu, Yifan Liu, Weiguo Fu, Yi Si
Intercellular communication between mesenchymal stem cells (MSCs) and their target cells in the perivascular environment is modulated by exosomes derived from MSCs. However, the potential role of exosome-mediated microRNA transfer in neointimal hyperplasia remains to be investigated. To evaluate the effects of MSC-derived exosomes (MSC-Exo) on neointimal hyperplasia, their effects upon vascular smooth muscle cell (VSMC) growth in vitro and neointimal hyperplasia in vivo were assessed in a model of balloon-induced vascular injury...
November 28, 2018: Journal of Cellular and Molecular Medicine
Jie Kong, Feng Wang, Jianbin Zhang, Yiyao Cui, Lin Pan, Wenjian Zhang, Jianyan Wen, Peng Liu
BACKGROUND: Exosomes released from endothelial progenitor cells (EPCs) play a protective role in various disease models. Both endothelial cell (EC) damage and smooth muscle cell (SMC) proliferation are involved in the pathological process of restenosis after angioplasty and stenting. Few studies have focused on the therapeutic role of exosomes in EC damage and SMC proliferation. In this study, we sought to investigate the effect of exosomes released by human fetal aorta-derived EPCs on the rat carotid artery balloon injury model in vivo...
December 2018: Journal of Surgical Research
Hiroomi Nishio, Hidetoshi Masumoto, Kazuhisa Sakamoto, Kazuhiro Yamazaki, Tadashi Ikeda, Kenji Minatoya
BACKGROUND: MicroRNA-145 (miR-145) reportedly alters the phenotype of vascular smooth muscle cells (VSMCs) from a proliferative to a contractile state. So far, viral or plasmid vectors have been experimentally used to transduce microRNAs into VSMCs. We hypothesized that a simple ex vivo microRNA delivery system using miR-145-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGA NPs) could control the VSMC phenotype and prevent intimal hyperplasia. METHODS: Jugular vein grafts of male Japanese white rabbits were soaked in phosphate-buffered saline, control microRNA (cont-miR)-loaded PLGA NP solution or miR-145-loaded PLGA NP solution for 30 minutes (n = 8 for each)...
October 6, 2018: Journal of Thoracic and Cardiovascular Surgery
Kang Xu, Mohanad Kh Al-Ani, Xin Pan, Qingjia Chi, Nianguo Dong, Xuefeng Qiu
Natural products are used widely for preventing intimal hyperplasia (IH), a common cardiovascular disease. Four different cells initiate and progress IH, namely, vascular smooth muscle, adventitial and endothelial cells, and circulation or bone marrow-derived cells. Vascular smooth muscle cells (VSMCs) play a critical role in initiation and development of intimal thickening and formation of neointimal hyperplasia. In this review, we describe the different originating cells involved in vascular IH and emphasize the effect of different natural products on inhibiting abnormal cellular functions, such as VSMC proliferation and migration...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Kamalika Mukherjee, Chi Young Song, Anne M Estes, Ahmad N Dhodi, Benjamin H Ormseth, Ji Soo Shin, Frank J Gonzalez, Kafait U Malik
Background We have reported that cytochrome P450 1B1 ( CYP 1B1), expressed in cardiovascular tissues, contributes to angiotensin II -induced vascular smooth muscle cell ( VSMC ) migration and proliferation and development of hypertension in various experimental animal models via generation of reactive oxygen species. This study was conducted to determine the contribution of CYP 1B1 to platelet-derived growth factor-BB-induced VSMC migration and proliferation in vitro and to neointimal growth in vivo. Methods and Results VSMC s isolated from aortas of male Cyp1b1 +/+ and Cyp1b1 -/- mice were used for in vitro experiments...
September 18, 2018: Journal of the American Heart Association
Mohamed Abdel-Wahab, Ralph Toelg, Robert A Byrne, Volker Geist, Mohamed El-Mawardy, Abdelhakim Allali, Tobias Rheude, Derek R Robinson, Mohammad Abdelghani, Dmitriy S Sulimov, Adnan Kastrati, Gert Richardt
BACKGROUND: Balloon dilatation or debulking seems to be essential to allow successful stent implantation in calcified coronary lesions. Compared with standard balloon predilatation, debulking using high-speed rotational atherectomy (RA) is associated with higher initial procedural success albeit with higher in-stent late lumen loss at intermediate-term follow-up. Whether modified (scoring or cutting) balloons (MB) could achieve similar procedural success compared with RA is not known...
October 2018: Circulation. Cardiovascular Interventions
Ron Waksman, Micaela Iantorno
PURPOSE OF REVIEW: This review will focus on our approach for the treatment of refractory in-stent restenosis. RECENT FINDINGS: The discovery of bare metal stents over three decades ago set a milestone in the evolution of percutaneous coronary intervention, which is currently the most widely performed procedure for the treatment of symptomatic coronary disease. However, the broad utilization of stents resulted in the new phenomenon of in-stent restenosis (ISR). Over the years, there has been an increase of the incidence of ISR despite continued improvement of drug-eluting stent (DES) technology...
October 22, 2018: Current Cardiology Reports
Cheng-Hung Lee, Ming-Jer Hsieh, Kuo-Sheng Liu, Che-Wei Cheng, Shang-Hung Chang, Shih-Jung Liu, Chao-Jan Wang, Ming-Yi Hsu, Kuo-Chun Hung, Yung-Hsin Yeh, Wei-Jan Chen, I-Chang Hsieh, Jyuhn-Huarng Juang, Ming-Shien Wen
Objective: The current treatment of atherosclerotic coronary heart disease with limus-eluting stents can lead to incomplete endothelialization and substantial impairment of arterial healing relative to treatment with bare-metal stents. The sustained and local delivery of ticagrelor, a reversibly binding P2Y12 receptor inhibitor, using hybrid biodegradable nanofibers/stents, was developed to reduce neointimal formation and endothelial dysfunction. Methods: In this investigation, a solution of ticagrelor, poly(D,L)-lactide-co-glycolide, and hexafluoro isopropanol was electrospun to fabricate ticagrelor-eluting nanofibrous drug-eluting stents...
2018: International Journal of Nanomedicine
Giuseppe Di Stolfo
BACKGROUND: Carotid stenting stimulates intimal proliferation through platelet and stem cell activation. OBJECTIVE: The aim of this study is to evaluate whether the administration before or after carotid stenting of clopidogrel loading dose may play a role on circulating endothelial progenitor cells, stromal cell-derived factor-1α (SDF-1α) and neointimal hyperplasia. METHODS: We recruited 13 patients (aged 74.52±7.23) with indication of carotid revascularization and in therapy with salicylic acid and statin...
September 29, 2019: Clinical Hemorheology and Microcirculation
Bo-Jun Cao, Xiao-Wen Wang, Lei Zhu, Rong-Jiang Zou, Zhi-Qian Lu
The long-term failure of vein grafts due to neointimal hyperplasia remains a difficult problem in cardiovascular surgery. Exploring novel approaches to prevent neointimal hyperplasia is important. MicroRNA-146a (miR-146a) plays an essential role in promoting vascular smooth muscle cell (VSMC) proliferation. Thus, the aim of the present study is to investigate whether adenovirus-mediated miR-146a sponge (Ad-miR-146a-SP) gene therapy could attenuate neointimal formation in rat vein grafts. (Ad-miR-146a-SP) was constructed to transfect cultured VSMCs and grafted veins...
October 6, 2018: IUBMB Life
Josip A Borovac, Domenico D'Amario, Rocco Vergallo, Italo Porto, Antonio Bisignani, Mattia Galli, Gianmarco Annibali, Rocco A Montone, Antonio Maria Leone, Giampaolo Niccoli, Filippo Crea
The recognition that obstructive disease of the epicardial coronary arteries, causing ischemic heart disease, can be treated with a percutaneous coronary intervention (PCI) has been a major discovery in cardiology in the last 40 years contributing, in particular, to the reduction of mortality associated to acute myocardial infarction (AMI). However, even in the era of drug-eluting stent (DES) implantation, a sizable proportion of patients who undergo PCI may develop late or very late post-implantation complications, that occur in the form of restenosis, neoatherosclerosis and/or in-stent thrombosis...
October 4, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
Zichang Zhao, Wei Shen, Hanbin Zhu, Lin Lin, Gening Jiang, Yongzhe Zhu, Hongyuan Song, Liang Wu
Background: Previous preclinical and clinical studies have demonstrated that zoledronate might inhibit neointimal hyperplasia at least partly by inhibiting the proliferation, adhesion and migration of vascular smooth muscle cells (VSMCs). However, whether zoledronate influences fibroblasts' proliferation and activation, which also play a key role in neointimal hyperplasia and vascular remodeling, remains largely unknown. In the present study, the effect of zoledronate on fibroblasts was investigated and the underlying molecular mechanisms were examined...
2018: Drug Design, Development and Therapy
Chaochao Dai, Mengyao Sun, Fengjiao Wang, Jiankang Zhu, Yaping Wei, Xiaotong Guo, Siqin Ma, Bo Dong, Gejin Wang, Fan Jiang, Jianli Wang
BACKGROUND: Transplant vasculopathy is a major cause of chronic rejection of transplanted organs. In the present study, we examined the effects of CX-5461, a novel selective inhibitor of RNA polymerase I, on development of transplant vasculopathy using a modified model of rat aortic transplantation. METHODS: The thoracic aortas from Fischer rats were transplanted into the abdominal cavity of Lewis rats. CX-5461 was mixed in pluronic gel and administered via perivascular release...
October 2018: Transplantation
Marcos García-Guimaraes, Paula Antuña, Javier Cuesta, Fernando Alfonso
Resorbable Magnesium Scaffolds (RMS) represent an interesting alternative to current drug-eluting stents. Current data from clinical trials seems to confirm good performance of these new devices with low rates of late device failure. Little is known about mechanisms leading to RMS failure. Herein, we present the first description of an early RMS in-scaffold restenosis. Optical coherence tomography (OCT) analysis at implantation detected acute non-severe malapposition and underexpansion as main promoters of RMS failure...
September 23, 2018: Catheterization and Cardiovascular Interventions
Qihong Yu, Wei Li, Dawei Xie, Xichuan Zheng, Tong Huang, Ping Xue, Bing Guo, Yang Gao, Chen Zhang, Ping Sun, Min Li, Guoliang Wang, Xiang Cheng, Qichang Zheng, Zifang Song
BACKGROUND: Transplant arteriosclerosis (TA) remains the major cause of chronic graft failure in solid organ transplantation. The phenotypic modulation of vascular smooth muscle cells (VSMCs) is a key event for the initiation and progression of neointimal formation and TA. This study aims to explore the role and underlying mechanism of phosphoinositide 3-kinases γ (PI3Kγ) in VSMC phenotypic modulation and TA. METHODS: The rat model of aortic transplantation was established to detect PI3Kγ expression and its role in neointimal formation and vascular remodeling in vivo...
October 2018: EBioMedicine
Srinivasa Raju Datla, Lula L Hilenski, Bonnie Seidel-Rogol, Anna E Dikalova, Mark Harousseau, Lili Punkova, Giji Joseph, W Robert Taylor, Bernard Lassègue, Kathy K Griendling
Polymerase delta-interacting protein 2 (Poldip2) is a multi-functional protein with numerous roles in the vasculature, including the regulation of cell apoptosis and migration, as well as extracellular matrix deposition; however, its role in VSMC proliferation and neointimal formation is unknown. In this study, we investigated the role of Poldip2 in intraluminal wire-injury induced neointima formation and proliferation of vascular smooth muscle cells in vitro and in vivo. Poldip2 expression was observed in the intima and media of human atherosclerotic arteries, where it colocalized with proliferating cell nuclear antigen (PCNA)...
September 20, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
Jun Ni, Wenbo Yang, Weifeng Shen, Ruiyan Zhang
It has been reported that heme oxygenase-1 (Hmox1) induction attenuates neointimal thickening. Here we further investigated the potential mechanisms regulating this important pathological process. We revealed that histone deacetylase 2 (HDAC2) was induced following Hmox1 induction under 1% oxygen treatment and this induction was attenuated after the treatment of siRNA against Hmox1. Interestingly, this HDAC2 induction was dependent on Hmox1 protein as well as its enzymatic activity, and was regulated by carbon monoxide released from heme degradation...
September 13, 2018: Free Radical Research
Baohua Huang, Yaping Li, Yanling Yao, Wei Shu, Ming Chen
Vine tea has been used as a medicinal herb in traditional Chinese medicine for hundreds of years. As the most abundant ingredient in vine tea, Dihydromyricetin (DHM) has been reported to exert anti-inflammatory, antioxidant, and anti-cardiovascular disease. However, the role of DHM in injury-induced neointimal formation remains poorly characterized. We determined the effects of DHM on ligation-induced carotid artery neointimal formation. We found that ligation-induced carotid artery neointimal formation could be significantly attenuated by DHM treatment...
September 5, 2018: European Journal of Pharmacology
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