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https://www.readbyqxmd.com/read/30119175/ginsenoside-re-inhibits-vascular-neointimal-hyperplasia-in-balloon-injured-carotid-arteries-through-activating-the-enos-no-cgmp-pathway-in-rats
#1
Yang Gao, Chen-Ying Gao, Ping Zhu, Shang-Fu Xu, Yun-Mei Luo, Jiang Deng, Dan-Li Yang
Ginsenoside Re (GS-Re) is one of the main ingredients of ginseng, a widely known Chinese traditional medicine, and has a variety of beneficial effects, including vasorelaxation, antioxidative, anti-inflammatory, and anticancer properties. The aims of the present study were to observe the effect of GS-Re on balloon injury-induced neointimal hyperplasia in the arteries and to investigate the mechanisms underlying this effect. A rat vascular neointimal hyperplasia model was generated by rubbing the endothelium of the common carotid artery (CCA) with a balloon, and GS-Re (12...
July 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30064835/perivascular-delivery-of-resolvin-d1-inhibits-neointimal-hyperplasia-in-a-rabbit-vein-graft-model
#2
Bian Wu, Evan C Werlin, Mian Chen, Giorgio Mottola, Anuran Chatterjee, Kevin D Lance, Daniel A Bernards, Brian E Sansbury, Matthew Spite, Tejal A Desai, Michael S Conte
OBJECTIVE: Inflammation is a key driver of excessive neointimal hyperplasia within vein grafts. Recent work demonstrates that specialized proresolving lipid mediators biosynthesized from omega-3 polyunsaturated fatty acids, such as resolvin D1 (RvD1), actively orchestrate the process of inflammation resolution. We investigated the effects of local perivascular delivery of RvD1 in a rabbit vein graft model. METHODS: Ipsilateral jugular veins were implanted as carotid interposition grafts through an anastomotic cuff technique in New Zealand white rabbits (3-4 kg; N = 80)...
July 28, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30013567/inhibition-of-angiopoietin-2-production-by-myofibrocytes-inhibits-neointimal-hyperplasia-after-endoluminal-injury-in-mice
#3
Daxin Chen, Ke Li, El-Li Tham, Lin-Lin Wei, Ning Ma, Philippa C Dodd, Yi Luo, Daniel Kirchhofer, John H McVey, Anthony Dorling
Fibrocytes are myeloid lineage cells implicated in wound healing, repair, and fibrosis. We previously showed that fibrocytes are mobilized into the circulation after vascular injury, including the immune-mediated injury that occurs after allogeneic transplantation. A common response to inflammatory vascular injury is intimal hyperplasia (IH), which, alongside vascular remodeling, results in progressive loss of blood flow, downstream ischemia, and end-organ fibrosis. This forms the pathological basis of transplant arteriosclerosis and other diseases including post-angioplasty re-stenosis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29982434/critical-role-of-histone-demethylase-jmjd3-in-the-regulation-of-neointima-formation-following-vascular-injury
#4
XiaoLing Luo, Di Yang, WeiJun Wu, Fen Long, ChenXi Xiao, Ming Qin, Betty YuenKwan Law, Rinkiko Suguro, Xin Xu, LeFeng Qu, XinHua Liu, Yi Zhun Zhu
Aims: Jumonji domain-containing protein 3 (JMJD3), also called lysine specific demethylase 6B (KDM6b), is an inducible histone demethylase which plays an important role in many biological processes, however, its function in vascular remodeling remains unknown. We aim to demonstrate that JMJD3 mediates vascular neointimal hyperplasia following carotid injury, and proliferation and migration in platelet-derived growth factor BB (PDGF-BB)-induced vascular smooth muscle cells (VSMCs). Methods and results: By using both genetic and pharmacological approaches, our study provides the first evidence that JMJD3 controls PDGF-BB-induced VSMCs proliferation and migration...
July 4, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29968090/drug-distribution-and-basic-pharmacology-of-paclitaxel-resveratrol-coated-balloon-catheters
#5
Ulrich Speck, Akvile Häckel, Eyk Schellenberger, Stefanie Kamann, Melanie Löchel, Yvonne P Clever, Daniel Peters, Bruno Scheller, Sabrina Trog, Stephanie Bettink
PURPOSE: To experimentally investigate a new homogenously paclitaxel/resveratrol-coated balloon catheter in terms of transport of the coating to the treated tissue and local effects including histology and functional tests. METHODS: Adherence of the coating to the balloon was explored by in vitro simulation of its passage to the lesion. Paclitaxel and resveratrol transfer to the vessel wall was investigated in porcine coronary and peripheral arteries. Matrix-assisted laser desorption/ionization (MALDI) was used for direct microscopic visualization of paclitaxel in arterial tissue...
July 2, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29951536/oxidation-prevents-hmgb1-inhibition-on-pdgf-induced-differentiation-of-multipotent-vascular-stem-cells-to-smooth-muscle-cells-a-possible-mechanism-linking-oxidative-stress-to-atherosclerosis
#6
Xiaohu Meng, Wenjie Su, Xuan Tao, Mingyang Sun, Rongchao Ying, Wei Wei, Baolin Wang
Atherosclerosis is considered as a multifactorial disease in terms of the pathogenic mechanisms. Oxidative stress has been implicated in atherogenesis, and the putative mechanisms of its action include oxidative modification of redox-sensitive signaling factors. High mobility group box 1 (HMGB1) is a key inflammatory mediator in atherosclerosis, but if oxidized it loses its activity. Thus, whether and how it participates in oxidative stress-induced atherosclerosis are not clear. The current study found that exogenous HMGB1 dose-dependently inhibited the proliferation of multipotent vascular stem cells and their differentiation to smooth muscle cells induced by platelet-derived growth factor...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29921375/mir-145-is-critical-for-modulation-of-vascular-smooth-muscle-cell-proliferation-in-human-carotid-artery-stenosis
#7
Z Han, H Hu, M Yin, X Li, J Li, L Liu, B Liu
miR-145 is highly expressed in vascular cells, where it regulates phenotypic switching and vascular homeostasis, but its role in carotid artery stenosis (CAS) is controversial. In the present study, the expression of miR-145 was assessed by real time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) in human samples (both plasma and/or endarterectomy samples) from patients with symptomatic CAS and in controls without CAS. The mouse carotid artery ligation (CAL) model was used to determine the role of miR-145 on vascular smooth muscle cells in vivo (VSMCs) by using a mimic of or an inhibitor of miR-145...
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29902532/mussel-inspired-catalytic-selenocystamine-dopamine-coatings-for-long-term-generation-of-therapeutic-gas-on-cardiovascular-stents
#8
Zhilu Yang, Ying Yang, Li Zhang, Kaiqin Xiong, Xiangyang Li, Feng Zhang, Jin Wang, Xin Zhao, Nan Huang
The development of a nitric oxide (NO)-generating surface with long-term, stable and controllable NO release improves the therapeutic efficacy of cardiovascular stents. In this work, we developed a "one-pot" method inspired by mussel adhesive proteins for copolymerization of selenocystamine (SeCA) and dopamine (Dopa) to form a NO-generating coating on a 316 L stainless steel (SS) stent. This "one-pot" method is environmentally friendly and easy to popularize, with many advantages including simple manufacturing procedure, high stability and no involvement of organic solvents...
June 7, 2018: Biomaterials
https://www.readbyqxmd.com/read/29845301/resveratrol-inhibits-angiotensin-ii%C3%A2-induced-proliferation-of-a7r5-cells-and-decreases-neointimal-hyperplasia-by-inhibiting-the-camkii%C3%A2-hdac4-signaling-pathway
#9
Xiaozhen Lin, Chuanfang Cheng, Junyang Zhong, Benrong Liu, Chengfeng Luo, Wenchao Ou, Pei Mo, Qiang Huang, Shiming Liu
Resveratrol has been reported to inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia following arterial injury; however, the underlying mechanisms remain unclear. The present study was designed to investigate the effects of resveratrol on angiotensin II (AngII)‑induced proliferation of A7r5 cells and explore the molecular mechanisms responsible for the observed effects. Resveratrol inhibited cell proliferation and migration, and decreased the AngII‑induced protein expression of α‑smooth muscle actin (α‑SMA), proliferating cell nuclear antigen (PCNA) and cyclin‑dependent kinase 4 (CDK4)...
July 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29803340/role-of-oxidative-stress-in-the-process-of-vascular-remodeling-following-coronary-revascularization
#10
Giovanna Gallo, Giorgia Pierelli, Maurizio Forte, Roberta Coluccia, Massimo Volpe, Speranza Rubattu
Percutaneous coronary interventions (PCI), including balloon angioplasty and implantation of both bare metal and drug eluting coronary stents, are associated with risk of restenosis and in-stent thrombosis. A better understanding of signals that regulate cellular proliferation, neointimal formation and vessel wall thickening following PCI may contribute to identify novel preventive and therapeutic strategies aimed to reduce the atherosclerosis progression and the consequent vascular sequelae. Among the possible mechanisms, an increased level of reactive oxygen species (ROS) is associated with endothelial dysfunction and vascular smooth muscle cells (VSMCs) proliferation and migration involved in the post-procedural remodeling process...
October 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29775572/gene-therapy-with-antisense-oligonucleotides-silencing-c-myc-reduces-neointima-formation-and-vessel-wall-thickness-in-a-mouse-model-of-vein-graft-disease
#11
Christina Maria Steger, Nikolaos Bonaros, Ralf Joachim Rieker, Johannes Bonatti, Thomas Schachner
Gene therapy for avoiding intimal hyperplasia of vein grafts after coronary artery bypass grafting is still discussed controversially. A promising application of gene therapy in vein grafts is the use of antisense oligonucleotides to block the expression of genes encoding cell cycle regulatory proteins in vascular smooth muscle cells. C-myc, either directly or by regulating the expression of other proteins, controls cell proliferation, apoptosis and cell survival, tissue remodeling, angiogenesis, cell metabolism, production of inflammatory and anti-inflammatory cytokines, and also participates in cell transformation...
August 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29773387/levan-based-fibrous-scaffolds-electrospun-via-co-axial-and-single-needle-techniques-for-tissue-engineering-applications
#12
Gülben Avsar, Deniz Agirbasli, Mehmet Ali Agirbasli, Oguzhan Gunduz, Ebru Toksoy Oner
This represents the first systematic study where levan polysaccharide was used to fabricate fibrous matrices by co-axial and single-needle electrospinning techniques. For this, hydrolyzed (hHL) and sulfated hydrolyzed (ShHL) Halomonas levan were chemically synthesized and used together with polycaprolactone (PCL) and polyethyleneoxide (PEO) for the spinning process. In co-axially spun matrices, ultimate tensile strength (UTS) were found to increase with increasing ShHL concentration and elongation at break of PCL + ShHL matrices increased up to ten-fold when compared to PCL matrices...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29770610/arsenic-trioxide-coated-stent-is-an-endothelium-friendly-drug-eluting-stent
#13
Yinping Zhao, Ruolin Du, Tian Zhou, Dongchuan Yang, Yuhua Huang, Yi Wang, Junli Huang, Xiaoyi Ma, Fugui He, Juhui Qiu, Guixue Wang
An ideal vascular stent would both inhibit in-stent restenosis (ISR) and promote rapid re-endothelialization. In the current study, the performance of arsenic trioxide (ATO)-drug eluting stent (AES) is compared with the bare metal stent, poly-lactic-co-glycolic acid-coating metal stent, and rapamycin-drug eluting stent (RES). In vivo AES is shown to prevent neointimal hyperplasia more efficiently than the others when implanted into the carotid arteries of rabbits. Moreover, AES promotes endothelial cells proliferation and re-endothelialization more quickly than RES...
May 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29765072/notoginsenoside-r1-inhibits-vascular-smooth-muscle-cell-proliferation-migration-and-neointimal-hyperplasia-through-pi3k-akt-signaling
#14
Haihong Fang, Shilin Yang, Yingying Luo, Cheng Zhang, Yi Rao, Renjing Liu, Yulin Feng, Jun Yu
Restenosis caused by neointimal hyperplasia significantly decreases long-term efficacy of percutaneous transluminal angioplasty (PTA), stenting, and by-pass surgery for managing coronary and peripheral arterial diseases. A major cause of pathological neointima formation is abnormal vascular smooth muscle cell (VSMC) proliferation and migration. Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng and has reported cardioprotective, neuroprotective and anti-inflammatory effects...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29750603/differential-gene-expression-patterns-in-vein-regions-susceptible-versus-resistant-to-neointimal-hyperplasia
#15
Sun Hyung Kwon, Li Li, Christi M Terry, Yan-Ting Shiu, Philip J Moos, Brett A Milash, Alfred K Cheung, Donald K Blumenthal
Arteriovenous hemodialysis graft (AVG) stenosis results in thrombosis and AVG failure, and develops chiefly as a consequence of localized neointimal hyperplasia (NH) formation in the vein-graft anastomosis region. The vein region just downstream of the vein-graft anastomosis (herein termed proximal vein region) is relatively resistant to NH. Prevention of AVG stenosis has been ineffective due in part to our limited understanding of the molecular processes involved in NH formation. We hypothesized that the gene expression profiles of the NH-prone and NH-resistant regions will be different from each other after graft placement, and analysis of their genomic profiles may yield therapeutic targets to prevent AVG stenosis...
May 11, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29749484/lysophosphatidic-acid-enhances-neointimal-hyperplasia-following-vascular-injury-through-modulating-proliferation-autophagy-inflammation-and-oxidative-stress
#16
Xuhui Shen, Jianjun Zou, Fuyong Li, Tianhe Zhang, Tongqi Guo
Lysophosphatidic acid (LPA), which is one of the intermediate products of membrane phospholipid metabolism, is a bioactive phospholipid that possesses diverse activities. In the present study, the effects of LPA on neointimal formation following vascular injury were investigated. A carotid artery balloon injury model was employed in the present study, and following vascular injury, rats received an intraperitoneal injection of 1 mg/kg LPA. Subsequently, histopathological alterations were assessed by hematoxylin and eosin staining, the expression levels of proliferating cell nuclear antigen (PCNA) were detected by immunohistochemistry, apoptosis was assessed via a terminal deoxynucleotidyl transferase‑mediated dUTP nick end labeling assay, and the expression levels of apoptosis‑associated and autophagy‑associated proteins were detected by western blotting...
July 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29731721/endothelial-aip1-regulates-vascular-remodeling-by-suppressing-nadph-oxidase-2
#17
Jiqin Zhang, Chaofei Chen, Li Li, Huanjiao J Zhou, Fenghe Li, Haifeng Zhang, Luyang Yu, Yuxin Chen, Wang Min
Objective: AIP1 expression is downregulated in human atherosclerotic plaques and global deletion of AIP1 in mice exacerbates atherosclerosis in ApoE-KO mouse models. However, the direct role of AIP1 in endothelium, vascular remodeling and associated vascular diseases has not been determined. Approach and Results: We used endothelial cell (EC)-specific AIP1-deficient (AIP1-ECKO) mice to define the role of AIP1 in vascular remodeling and intima-media thickening in a mouse carotid artery ligation model characterized by both neointimal hyperplasia and inward vessel remodeling...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29724149/mesenchymal-stem-cell-sheets-exert-antistenotic-effects-in-a-rat-arterial-injury-model
#18
Jun Homma, Hidekazu Sekine, Katsuhisa Matsuura, Eiji Kobayashi, Tatsuya Shimizu
Restenosis after catheter or surgical intervention substantially affects the prognosis of arterial occlusive disease. Mesenchymal stem cells (MSCs) may have antistenotic effects on injured arteries. MSC transplantation from the adventitial side of an artery is safer than endovascular transplantation but has not been extensively examined. In this study, a rat model of femoral artery injury was used to compare the antistenotic effects of transplanted cell sheets and transplanted cell suspensions. Rat adipose-derived stem cells (ASCs) were used as the source of MSCs...
July 23, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29723537/ring-finger-protein-10-prevents-neointimal-hyperplasia-by-promoting-apoptosis-in-vitro-and-in-vivo
#19
Guiquan Yu, Jing Chen, Siyu Li, Peng Pu, Wei Huang, Yongpeng Zhao, Xin Peng, Ruiyu Wang, Han Lei
AIMS: Vascular restenosis and neointimal hyperplasia are enhanced in metabolic syndrome (MetS). Vascular smooth muscle cell (VSMC) proliferation is a key step during restenosis and is suppressed by RING finger protein 10 (RNF10). However, the effect of RNF10 on neointimal hyperplasia is unknown. In the present study, we explored whether RNF10 over-expression prevents neointimal hyperplasia in a MetS rat model and in cultured VSMCs exposed to high glucose. MAIN METHODS: An adenovirus encoding RNF10 (Ad-RNF10) or control green fluorescent protein (Ad-GFP) was delivered to balloon-injured carotid arteries in MetS rats and cultured rat VSMCs exposed to high glucose...
April 30, 2018: Life Sciences
https://www.readbyqxmd.com/read/29704172/a-direct-oral-factor-xa-inhibitor-edoxaban-ameliorates-neointimal-hyperplasia-following-vascular-injury-and-thrombosis-in-apolipoprotein-e-deficient-mice
#20
Yoshiyuki Morishima, Yuko Honda
Vascular injury activates the coagulation cascade. Some studies report that coagulation factor Xa and thrombin are implicated in proliferation of vascular smooth muscle cells and neointimal hyperplasia after vascular injury. The aim of this study was to determine the effect of an oral direct factor Xa inhibitor, edoxaban, on neointimal hyperplasia following the carotid artery injury in apolipoprotein E (ApoE)-deficient mice. Vascular injury was induced by the application of 10% ferric chloride to the carotid artery for 3 min in ApoE-deficient mice...
July 2018: Journal of Thrombosis and Thrombolysis
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