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Intra Operative Monitoring

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https://www.readbyqxmd.com/read/30323719/quality-assessment-and-interference-detection-in-targeted-mass-spectrometry-data-using-machine-learning
#1
Shadi Toghi Eshghi, Paul Auger, W Rodney Mathews
Advances in the field of targeted proteomics and mass spectrometry have significantly improved assay sensitivity and multiplexing capacity. The high-throughput nature of targeted proteomics experiments has increased the rate of data production, which requires development of novel analytical tools to keep up with data processing demand. Currently, development and validation of targeted mass spectrometry assays require manual inspection of chromatographic peaks from large datasets to ensure quality, a process that is time consuming, prone to inter- and intra-operator variability and limits the efficiency of data interpretation from targeted proteomics analyses...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/30302425/experimental-pericardial-tamponade-translation-of-a-clinical-problem-to-its-large-animal-model
#2
Gábor Bari, Szilárd Szűcs, Dániel Érces, Mihály Boros, Gabriella Varga
Objectives: Pericardial tamponade is a life-threatening medical emergency, when the hemodynamic consequences of low cardiac output severely disturb the perfusion of the peripheral tissues. Our aim was to design a reliable large animal model to reproduce the clinical scenario with the relevant pathophysiological consequences of pericardial tamponade -induced cardiogenic shock. Material and Methods: Anesthetized Vietnamese mini pigs were used (n=12). Following laparotomy, a cannula was fixed into the pericardium through the diaphragm without thoracotomy...
2018: Turkish journal of surgery
https://www.readbyqxmd.com/read/30284002/bone-mineral-density-as-a-marker-of-hip-implant-longevity-a-prospective-assessment-of-a-cementless-stem-with-dual-energy-x-ray-absorptiometry-at-twenty-years
#3
Giuseppe Sessa, Luciano Costarella, Calogero Puma Pagliarello, Antonio Di Stefano, Andrea Sessa, Gianluca Testa, Vito Pavone
PURPOSE: Bone remodeling around the femoral component after total hip arthroplasty (THA) is considered to be an important factor in long-term stability and seems to be strictly related to the stem design, coating, and fixation. Stress shielding, micro-movement, and high intra-articular fluid pressure might activate macrophages and osteoclasts, causing progressive bone density decreases. Here we analyze the bone mineral density (BMD) around a cementless femoral stem during a 20-year period to better understand the adaptive bone changes around such implants during long-term follow-up...
October 3, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/30277955/intra-and-postoperative-complications-of-le-fort-i-maxillary-osteotomy
#4
Majid Eshghpour, Vajiheh Mianbandi, Sahand Samieirad
BACKGROUND: The Le Fort I maxillary osteotomy is a versatile and simple procedure, which has gained popularity nowadays, to correct a wide range of malocclusion and maxillofacial deformities. This procedure is often associated with significant but rare postoperative complications. The aim of this study was to evaluate the types and frequencies of intra- and perioperative complications related to Le Fort I osteotomies in noncleft Iranian patients. MATERIALS AND METHODS: In this prospective study, all the healthy systemic patients, (ASA I, II) with the age range of 18 to 30 years from both genders, who had the skeletal class II or III deformities and required only isolated 1-piece maxillary Le Fort I osteotomy, were included in this study...
October 1, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30274570/-intra-operative-continuous-non-invasive-blood-pressure-monitoring
#5
Kirstine Toft Conradsen, Niels Peter Ekeløf, Nikolai Hoffmann-Petersen, Sarah Ekeløf
Intra-operative hypotension is associated with increased risk of 30-day mortality and organ ischaemia. Thus, a reliable monitoring of blood pressure is desirable. New clinical studies indicate, that monitoring of middle arterial pressure with continuous non-invasive monitoring during stable haemodynamic conditioning provides accurate changes in blood pressure. The potential of continuous non-invasive monitoring is promising, but not fully developed.
September 24, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/30272672/standardized-measurement-of-nasal-membrane-transepithelial-potential-difference-npd
#6
George M Solomon, Inez Bronsveld, Kathryn Hayes, Michael Wilschanski, Paola Melotti, Steven M Rowe, Isabelle Sermet-Gaudelus
We describe a standardized measurement of nasal potential difference (NPD). In this technique, cystic fibrosis transmembrane conductance regulator (CFTR) and the epithelial sodium channel (ENaC) function are monitored by the change in voltage across the nasal epithelium after the superfusion of solutions that modify ion channel activity. This is enabled by the measurement of the potential difference between the subcutaneous compartment and the airway epithelium in the nostril, utilizing a catheter in contact with the inferior nasal turbinate...
September 13, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30270476/anterior-segment-optical-coherence-tomography-its-application-in-clinical-practice-and-experimental-models-of-disease
#7
REVIEW
Haihan Jiao, Lisa J Hill, Laura E Downie, Holly R Chinnery
Optical coherence tomography (OCT) provides non-invasive, high-resolution in vivo imaging of the ocular surface and anterior segment. Over the years, it has become an essential tool for evaluating the anterior segment of the eye to monitor ocular development and ocular pathologies in both the clinical and research fields of ophthalmology and optometry. In this review, the clinical applications relating to the use of anterior segment OCT for imaging and quantifying normal and pathological features of the ocular surface, cornea, anterior chamber, and aqueous outflow system are summarised in a range of human ocular diseases...
October 1, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/30257771/-limited-versus-extended-lateral-approach-for-osteosynthesis-of-calcaneal-fractures-comparison-of-temporal-and-dynamic-parameters-of-the-gait-cycle
#8
S Jandová, J Pazour
PURPOSE OF THE STUDY Currently, operative treatment is preferred in dislocated calcaneal fractures. Most frequently used is the extended lateral approach, the disadvantage of which is the risk of early complications. Therefore, less invasive operative techniques are sought that would reduce the risk of such complications. The presented study aimed to compare the two different surgical approaches with respect to the restoration of gait stereotype using the objective pedobarography. We assume that the limited operative approach in osteosynthesis of intra-articular calcaneal fractures results in comparable or earlier restoration of gait stereotype with regard to temporal and dynamic parameters compared to the extended lateral approach...
2018: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/30251518/-determination-of-nine-phthalate-ester-metabolites-in-human-urine-using-ultra-high-performance-liquid-chromatography-tandem-triple-quadrupole-mass-spectrometry
#9
Xu Zhang, Tian Qiu, Hui Fu, Yanwei Yang, Feng Zhao, Shaobin Lin, Xiaojian Hu
A method was developed to determine trace concentrations of phthalate ester (PAE) metabolites in human urine by using ultra high performance liquid chromatography-triple quadrupole mass spectrometry. Aliquots (2 mL) of human urine samples were purified using strong anion-exchange solid-phase extraction after enzymatic deconjugation by glucuronidase for 2 h. The separation was performed on a Waters ACQUITY UPLC BEH Phenyl column (100 mm×2.1 mm, 1.7 μ m) with gradient elution by 0.1% (v/v) acetic acid in acetonitrile and 0...
September 8, 2018: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/30251058/identify-and-monitor-clinical-variation-using-machine-intelligence-a-pilot-in-colorectal-surgery
#10
Kamal Maheshwari, Jacek Cywinski, Piyush Mathur, Kenneth C Cummings, Rafi Avitsian, Timothy Crone, David Liska, Francis X Campion, Kurt Ruetzler, Andrea Kurz
Standardized clinical pathways are useful tool to reduce variation in clinical management and may improve quality of care. However the evidence supporting a specific clinical pathway for a patient or patient population is often imperfect limiting adoption and efficacy of clinical pathway. Machine intelligence can potentially identify clinical variation and may provide useful insights to create and optimize clinical pathways. In this quality improvement project we analyzed the inpatient care of 1786 patients undergoing colorectal surgery from 2015 to 2016 across multiple Ohio hospitals in the Cleveland Clinic System...
September 24, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/30233000/comparison-of-normal-saline-and-balanced-crystalloid-plasmalyte-in-patients-undergoing-elective-craniotomy-for-supratentorial-brain-tumors-a-randomized-controlled-trial
#11
Ankita Dey, S Adinarayanan, Prasanna Udupi Bidkar, Rakesh K Bangera, V Balasubramaniyan
Background: The choice of fluid is important in neurosurgical patients, who may be dehydrated due to the administration of diuretics in order to reduce cerebral edema. Normal saline, the infused fluid routinely used in neurosurgical patients, can cause hyperchloremic metabolic acidosis. A balanced crystalloid (BC) may help to maintain the metabolic status more favorably in these patients, without adversely affecting brain relaxation. Methods: We conducted a prospective, randomized controlled trial on patients undergoing elective craniotomy for supratentorial tumor resection under general anesthesia...
September 2018: Neurology India
https://www.readbyqxmd.com/read/30223837/comparison-of-non-triggered-magnetic-resonance-imaging-and-echocardiography-for-the-assessment-of-left-atrial-volume-and-morphology
#12
Nicoline W E van den Berg, Dean R P P Chan Pin Yin, Wouter R Berger, Jolien Neefs, Rianne H A C M De Bruin-Bon, Henk A Marquering, Annelie Slaar, R Nils Planken, Joris R de Groot
BACKGROUND: Advanced atrial fibrillation (AF) patients have persistent AF, failed previous catheter ablation and/or an enlarged left atrium (LA), which is associated with a reduced success of AF ablation. Transthoracic echocardiography (TTE) and contrast enhanced magnetic resonance angiography (CE-MRA) are available to assess LA volume. However, it is unknown how these modalities relate in patients with advanced AF. We therefore compared the reproducibility of TTE and non-triggered CE-MRA in advanced AF patients and their ability to select patients with successful thoracoscopic AF ablation...
September 18, 2018: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/30220169/-clinical-characteristics-of-silent-pheochromocytoma
#13
H Yang, H H Wu, N Bu, L Zhou, J Q Zhang, L Q Zhou, X H Guo
Objective: To summarize the clinical characteristics of silent paraganglioma. Methods: A total of 247 pheochromocytoma cases in Peking University First Hospital between January 1993 and December 2015 were analyzed retrospectively.The cases were divided into two groups according to whether they had hypertension: non-silent group (193 cases) and silent group (53 cases), then the clinical characteristics between the groups were compared, and the clinical features of silent pheochromocytoma were reviewed. Results: There were 53 silent pheochromocytoma cases in this study, which accounted for 21...
September 11, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/30188837/end-to-end-noise-model-for-intra-body-terahertz-nanoscale-communication
#14
Hadeel Elayan, Cesare Stefanini, Raed M Shubair, Josep Miquel Jornet
In-vivo Wireless Nanosensor Networks (iWNSNs) are paving the way towards transformative healthcare solutions. These networks are expected to enable a plethora of applications including drug-delivery, bio-sensing, and health monitoring. With the development of miniature plasmonic signal sources, antennas and detectors, wireless communications among intrabody nanodevices will expectedly be enabled in the Terahertz (THz) frequency band (0.1-10 THz). Several propagation models were recently developed to analyze and assess the feasibility of intra-body electromagnetic (EM) nanoscale communication...
September 6, 2018: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/30165332/lc-ms-ms-assay-for-the-determination-of-a-novel-d-peptide-antagonist-of-cxcr4-in-rat-plasma-and-its-application-to-a-preclinical-pharmacokinetic-study
#15
Yinsong Zhu, Shu Yang, Juan Wang, Yujia Mao, Yan Xu, Jing An, Ziwei Huang
DV1 is a potent and selective D-peptide antagonist of CXCR4 and being developed as a novel drug candidate molecule. For preclinical pharmacokinetic study of DV1, we established an efficient and reliable liquid chromatography coupled to tandem mass spectrometric (LC-MS/MS) method for the assay of DV1 in rat plasma. Plasma samples were acidified by formic acid and then their protein content precipitated by acetonitrile. Sample separation was processed with a C18 column (4.6 mm × 100 mm, 5 μm) and washed by a water-acetonitrile gradient mobile phase containing 0...
November 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30151746/simultaneous-determination-of-rivaroxaban-and-enalapril-in-rat-plasma-by-uplc-ms-ms-and-its-application-to-a-pharmacokinetic-interaction-study
#16
Shu Zheng, Shun-Bin Luo, Yi-Bin Mei, Jing Guo, Li-Jun Tong, Qiang Zhang, Xia-Yan Ye
BACKGROUND AND OBJECTIVES: There have been no animal experiments and clinical studies on the pharmacokinetic interaction between rivaroxaban and enalapril. To investigate whether a potential pharmacokinetic interaction is present between rivaroxaban and enalapril, a rapid and sensitive Ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated to determine the concentration of rivaroxaban and enalapril in rat plasma and was then applied to a pharmacokinetic interaction study...
August 27, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/30150474/reliable-and-easy-to-use-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms-assay-for-quantification-of-olorofim-f901318-a-novel-antifungal-drug-in-human-plasma-and-serum
#17
Carsten Müller, Cornelia Fietz, Philipp Koehler, Graham Sibley, Achu Che Awah Nforbugwe, Thomas Streichert, Martin H J Wiesen
Background A fast and easy-to-use liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination and quantification of a novel antifungal drug, Olorofim (formerly F901318), a member of the novel class of orotomides, in human plasma and serum was developed and validated. Methods Sample preparation was based on protein precipitation with acetonitrile and subsequent centrifugation. An isotope labeled analogue of F901318 was employed as internal standard. Chromatographic separation was achieved using a 50 mm × 2...
August 27, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/30150028/intra-operative-cortical-motor-mapping-using-subdural-grid-electrodes-in-children-undergoing-epilepsy-surgery-evaluation-and-comparison-with-the-conventional-extra-operative-motor-mapping
#18
Puneet Jain, Robyn Whitney, Samuel Strantzas, Blathnaid McCoy, Ayako Ochi, Hiroshi Otsubo, O Carter Snead, Shelly Weiss, Elizabeth Donner, Elizabeth Pang, Rohit Sharma, Amrita Viljoen, Anne Keller, James M Drake, James T Rutka, Cristina Go
OBJECTIVES: The objective of this study was to review our experience with intra-operative "train of five" stimulation using subdural grid for motor mapping in children undergoing epilepsy surgery evaluation. METHODS: Twenty consecutive children below 18-years of age with drug-refractory epilepsy who underwent invasive-EEG monitoring using subdural-grid placement and intra-operative motor mapping using direct cortical stimulation by sub-dural grid electrodes (IODCS-SDG) at our institution between January-2016 and June-2017 were reviewed...
August 12, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/30134493/-transaxillary-robot-assisted-thyroidectomy-results-and-acceptance-of-a-new-surgical-technique
#19
Elisabeth Maurer, Sabine Wächter, Max Albers, Katharina Holzer, Detlef K Bartsch
BACKGROUND: In recent years, different remote-access approaches in thyroid surgery have been developed and partially established. The aim is mainly to improve cosmetics by avoiding a visible scar on the neck. We report here our experiences with transaxillary robot-assisted thyroidectomy (TRAT). METHODS: As part of an observational trial, TRAT was offered to patients with indication for a hemithyroidectomy because of benign goitre with a lobe volume up to 40 ml...
August 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/30093188/the-effects-of-secondhand-smoke-exposure-on-postoperative-pain-and-ventilation-values-during-one-lung-ventilation-a-prospective-clinical-trial
#20
Ahmet Selim Ozkan, Muharrem Ucar, Sedat Akbas
OBJECTIVES: To investigate the relationships between secondhand smoke (SHS) exposure and oxygenation during one-lung ventilation (OLV) in lobectomy surgery and between SHS exposure and postoperative analgesic consumption. DESIGN: Prospective study. SETTING: University, Faculty of Medicine, operating room. PARTICIPANTS: Sixty adult patients with American Society of Anesthesiologists score II to III, aged 18 to 65 years, with a body mass index (BMI) <35 kg/m2 scheduled for lobectomy surgery by open thoracotomy...
July 2, 2018: Journal of Cardiothoracic and Vascular Anesthesia
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