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https://www.readbyqxmd.com/read/30234607/ifnl3-4-polymorphisms-are-associated-with-aids-related-kaposi-s-sarcoma
#1
Stéphanie Bibert, Agnieszka Wojtowicz, Patrick Taffé, Philip E Tarr, Enos Bernasconi, Hansjakob Furrer, Huldrych F Günthard, Matthias Hoffmann, Laurent Kaiser, Michael Osthoff, Jacques Fellay, Matthias Cavassini, Pierre-Yves Bochud
BACKGROUND: Kaposi's sarcoma (KS), the most common AIDS related cancer, represents a major public concern in resource-limited countries. Single nucleotide polymorphisms within the Interferon lambda 3/4 region (IFNL3/4) determine the expression, function of IFNL4, and influence the clinical course of an increasing number of viral infections. OBJECTIVES: To analyze whether IFNL3/4 variants are associated with susceptibility to AIDS-related KS among men who have sex with men (MSM) enrolled in the Swiss HIV Cohort Study (SHCS)...
September 17, 2018: AIDS
https://www.readbyqxmd.com/read/30157968/interferon-%C3%AE-3-4-genetic-variants-and-interferon-%C3%AE-3-serum-levels-are-biomarkers-of-lupus-nephritis-and-disease-activity-in-taiwanese
#2
Ji-Yih Chen, Chin-Man Wang, Tai-Di Chen, Yeong-Jian Jan Wu, Jing-Chi Lin, Ling Ying Lu, Jianming Wu
BACKGROUND: Type III interferons (IFNs) or IFN-λs are the newly discovered cytokines that primarily target the cells of epithelial and myeloid lineages, which are major components of kidneys. The current study aimed to investigate whether IFN-λs are involved in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis. METHODS: TaqMan allele discrimination assays were used to determine IFNL3/4 SNP genotypes of 1620 healthy controls and 1013 SLE patients (two independent cohorts consisting of 831 and 182 subjects, respectively) from Taiwan...
August 29, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/30016335/no-association-between-ifnl3-il28b-genotype-and-response-to-peginterferon-alfa-2a-in-hbeag-positive-or-negative-chronic-hepatitis-b
#3
Lai Wei, Heiner Wedemeyer, Yun-Fan Liaw, Henry Lik-Yuen Chan, Teerha Piratvisuth, Patrick Marcellin, Jidong Jia, Deming Tan, Wan-Cheng Chow, Maurizia R Brunetto, Moisés Diago, Selim Gurel, Viacheslav Morozov, Hua He, Yonghong Zhu, Cynthia Wat, Bernadette Surujbally, Alexander J Thompson
BACKGROUND & AIMS: It has yet to be firmly established whether host IFNL3 (IL28B) genotype influences interferon responsiveness in patients with chronic hepatitis B. We investigated associations between single-nucleotide polymorphisms (SNPs) in the IFNL3 region and response to peginterferon alfa-2a in 701 patients enrolled in three large, randomized, international studies. METHODS: Responses were defined as hepatitis B surface antigen (HBsAg) loss and/or hepatitis B e antigen (HBeAg) seroconversion plus hepatitis B virus (HBV) DNA <2000 IU/ml in HBeAg-positive patients, and HBsAg loss and/or HBV DNA <2000 IU/ml in HBeAg-negative patients (24 weeks after end of treatment)...
2018: PloS One
https://www.readbyqxmd.com/read/29976152/a-novel-locus-on-mouse-chromosome-7-that-influences-survival-after-infection-with-tick-borne-encephalitis-virus
#4
Martin Palus, Yahya Sohrabi, Karl W Broman, Hynek Strnad, Matyáš Šíma, Daniel Růžek, Valeriya Volkova, Martina Slapničková, Jarmila Vojtíšková, Lucie Mrázková, Jiří Salát, Marie Lipoldová
BACKGROUND: Tick-borne encephalitis (TBE) is the main tick-borne viral infection in Eurasia. Its manifestations range from inapparent infections and fevers with complete recovery to debilitating or fatal encephalitis. The basis of this heterogeneity is largely unknown, but part of this variation is likely due to host genetic. We have previously found that BALB/c mice exhibit intermediate susceptibility to the infection of TBE virus (TBEV), STS mice are highly resistant, whereas the recombinant congenic strain CcS-11, carrying 12...
July 6, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29962372/hypothiocyanous-acid-suppresses-polyi-c-induced-antiviral-responses-by-modulating-irf3-phosphorylation-in-human-airway-epithelial-cells
#5
Thuy Thu Nguyen, Shoichi Suzuki, Ryuichi Sugamata, Fuyu Ito, Dat Huu Tran, Tomoko Yamamoto, Shoji Kawachi, Kazuo Suzuki
Pattern recognition receptors recognize RNA viruses and trigger type I and III interferon (IFN) production and apoptosis to limit viral replication and spread. Some innate immune cells produce oxidants in response to viral infection to protect against invasion. Recent studies have demonstrated the virucidal activity of hypothiocyanous acid (HOSCN), an oxidant generated by the peroxidase-catalyzed reaction of thiocyanate with hydrogen peroxide. However, the effects of HOSCN on host antiviral responses are still unknown...
June 2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29866105/polymorphisms-in-the-th17-cell-related-rorc-gene-are-associated-with-spontaneous-clearance-of-hcv-in-chinese-women
#6
Zhe Xie, Yuantao Li, Lu Long, Hua Liang, Weiping Cai, Tao Shen
BACKGROUND: Female gender and favorable IFNL3 genotypes are the primary independent predictors of spontaneous clearance of HCV infection. However, chronic hepatitis C infection occurs in numerous women carrying favorable IFNL3 genotypes, indicating that other host and/or virological factors contribute to the prognosis of infection. METHODS: A cohort of 137 anti-HCV-positive female Han Chinese cases, including 64 chronic HCV carriers and 73 HCV spontaneous resolvers, was recruited in the study...
June 4, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29746888/nearly-neutral-evolution-in-ifnl3-gene-retains-the-immune-function-to-detect-and-clear-the-viral-infection-in-hcv
#7
Pratichi Singh, J Febin Prabhu Dass
IFNL3 gene plays a crucial role in immune defense against viruses. It induces the interferon stimulated genes (ISGs) with antiviral properties by activating the JAK-STAT pathway. In this study, we investigated the evolutionary force involved in shaping the IFNL3 gene to perform its downstream function as a regulatory gene in HCV clearance. We have selected 25 IFNL3 coding sequences with human gene as a reference sequence and constructed a phylogeny. Furthermore, rate of variation, substitution saturation test, phylogenetic informativeness and differential selection were also analysed...
May 7, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29739095/distribution-of-il28b-rs12979860-and-rs8099917-genotypes-in-patients-with-chronic-hepatitis-c-virus-infection-in-tianjin-china
#8
Kunyan Qiao, Congdoanh Trieu, Zhixiao Huo, Yanan Du, Wei Hou
BACKGROUND: Two single-nucleotide polymorphisms (SNPs) rs12979860 (C/T) and rs8099917 (T/G), near the interleukin 28B (IL28B, also known as IFN lambda-3, IFNL3) gene, have a strong association with both spontaneous and treatment-induced hepatitis C virus (HCV) clearance. IL28B polymorphisms have shown a marked differential distribution with regional and ethnic variation. The study aimed to investigate the distribution of IL28B rs12979860 and rs8099917 genotypes in patients with chronic hepatitis C (CHC) in Tianjin, China...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29562888/ifn%C3%AE-3-4-locus-polymorphisms-and-ifn%C3%AE-3-circulating-levels-are-associated-with-copd-severity-and-outcomes
#9
Adrian Egli, Jyotshna Mandal, Desiree M Schumann, Michael Roth, Brad Thomas, D Lorne Tyrrell, Francesco Blasi, Kostantinos Kostikas, Wim Boersma, Branislava Milenkovic, Alicia Lacoma, Katharina Rentsch, Gernot G U Rohde, Renaud Louis, Joachim G Aerts, Tobias Welte, Antoni Torres, Michael Tamm, Daiana Stolz
BACKGROUND: Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations? METHODS: Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of IFNL3 in COPD patients were determined and associated with disease activity and outcome during a median follow-up of 24 months...
March 21, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29397014/host-genetic-factors-associated-with-hepatocellular-carcinoma-in-patients-with-hepatitis-c-virus-infection-a-systematic-review
#10
REVIEW
A J Walker, C J Peacock, V Pedergnana, W L Irving
Hepatitis C virus (HCV)-infected patients are at risk of developing hepatocellular carcinoma (HCC). Individuals at heightened risk could be targeted by intensive follow-up surveillance. We have conducted a systematic review of the literature to identify host genetic predisposition to HCC in HCV-infected patients. A comprehensive search of Medline and Embase databases was performed, and the strength of evidence of associations for each gene on development of HCC was evaluated. We identified 166 relevant studies, relating to 137 different genes, or combinations thereof...
May 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29369421/genetic-variation-in-il28b-ifnl3-and-response-to-interferon-alpha-treatment-in-myeloproliferative-neoplasms
#11
Marie Lindgren, Jan Samuelsson, Lars Nilsson, Håvar Knutsen, Waleed Ghanima, Johan Westin, Peter L Johansson, Björn Andréasson
OBJECTIVE: In myeloproliferative neoplasms (MPN), interferon-alpha (IFN-α) is an effective treatment with disease-modifying properties but currently with no clear predictors of treatment outcome. Recent genomewide association studies in chronic hepatitis C have found a strong influence of genetic polymorphism near the IL28B (IFNL3) gene in response to IFN-α treatment. In this study, we sought to evaluate the prognostic impact of IL28B rs12979860, rs8099917, and rs12980275 on IFN-α treatment response in myeloproliferative neoplasms...
May 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29330418/hla-b-hla-c-and-kir-improve-the-predictive-value-of-ifnl3-for-hepatitis-c-spontaneous-clearance
#12
Mario Frias, Antonio Rivero-Juárez, Diego Rodriguez-Cano, Ángela Camacho, Pedro López-López, María Ángeles Risalde, Bárbara Manzanares-Martín, Teresa Brieva, Isabel Machuca, Antonio Rivero
IFNL3 is the strongest predictor of spontaneous resolution (SR) of hepatitis C virus (HCV), however, consideration of IFNL3 genotype alone is of limited clinical value for the prediction of SR or chronic HCV infection. The objective of this study was to analyze the impact of HLA-B, HLA-C and KIRs on SR, as well as their additive effects on the predictive value of the IFNL3 genotype. We conducted a retrospective study of HIV patients that included both SR and chronic HCV patients. In our study, 61.6% of patients with IFNL3 CC achieved SR, and 81...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29297316/a-database-of-human-genes-and-a-gene-network-involved-in-response-to-tick-borne-encephalitis-virus-infection
#13
Elena V Ignatieva, Alexander V Igoshin, Nikolay S Yudin
BACKGROUND: Tick-borne encephalitis is caused by the neurotropic, positive-sense RNA virus, tick-borne encephalitis virus (TBEV). TBEV infection can lead to a variety of clinical manifestations ranging from slight fever to severe neurological illness. Very little is known about genetic factors predisposing to severe forms of disease caused by TBEV. The aims of the study were to compile a catalog of human genes involved in response to TBEV infection and to rank genes from the catalog based on the number of neighbors in the network of pairwise interactions involving these genes and TBEV RNA or proteins...
December 28, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29226133/circulating-interferon-%C3%AE-3-responsiveness-to-hbv-vaccination-and-hbv-hcv-infections-in-haemodialysis-patients
#14
Alicja E Grzegorzewska, Monika K Świderska, Adrianna Mostowska, Paweł P Jagodziński
The IFN- λ 3 gene (IFNL3) plays a role in HCV clearance. We investigated circulating IFN- λ 3 and IFNL3 SNPs in haemodialysis patients who differed in their response to HBV vaccination and their HBV/HCV infection status. In 201 patients, plasma IFN- λ 3 was determined using ELISA. IFNL3 SNPs (rs12979860, rs8099917) were genotyped using HRM analysis. Differences in IFN- λ 3 levels were shown between responders and nonresponders to HBV vaccination and between HBsAg-positive patients and those who developed anti-HBs after infection and became HBsAg negative...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29130827/association-of-single-nucleotide-polymorphisms-in-immune-related-genes-with-development-of-dengue-hemorrhagic-fever-in-a-mexican-population
#15
Angélica Berenice Vargas-Castillo, Karina Ruiz-Tovar, Héctor Vivanco-Cid, Sarai Quiroz-Cruz, Alejandro Escobar-Gutiérrez, Jorge Francisco Cerna-Cortes, Gilberto Vaughan, Salvador Fonseca-Coronado
Single-nucleotide polymorphisms (SNPs) occurring in immune-related genes have been associated with risk or protection for development of dengue, depending on ethnicity. Here, we genotyped seven SNPs located in immune response-related genes to identify their association with severe forms of dengue in patients from an endemic region in Mexico. One hundred and thirty-eight patients with dengue fever (DF), thirty-one dengue hemorrhagic fever (DHF) patients, as well as 304 healthy donors were genotyped by using a TaqMan-based approach...
April 2018: Viral Immunology
https://www.readbyqxmd.com/read/29104462/association-of-ifnl3-genotype-with-hepatic-steatosis-in-chronic-hepatitis-c-patients-treated-with-peginterferon-and-ribavirin-combination-therapy
#16
Shingo Nakamoto, Fumio Imazeki, Tatsuo Kanda, Shuang Wu, Masato Nakamura, Shin Yasui, Akinobu Tawada, Rintaro Mikata, Tetsuhiro Chiba, Makoto Arai, Osamu Yokosuka, Hiroshi Shirasawa
BACKGROUND: Genetic variation near the interferon lambda 3 ( IFNL3 ) is known to be associated with response to pegylated interferon (pegIFN) and ribavirin combination therapy in patients with chronic hepatitis C virus (HCV) infection which is often accompanied by hepatic steatosis. AIMS: We examined whether this genetic variation is associated with host lipids and treatment response. METHODS: A total of 101 Japanese patients who had underwent liver biopsy before treatment with pegIFN and ribavirin for HCV genotype 1b infection were retrospectively analyzed for association between IFNL3 genotypes (rs8099917) and clinical factors including histopathological features of the liver...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29062905/the-impact-of-the-recipient-and-donor-interferon-lambda-3-polymorphism-on-the-course-of-hcv-infection-following-liver-transplantation
#17
Renata Wieczorek-Godlewska, Rafał Płoski, Agnieszka Perkowska-Ptasińska, Olga Tronina, Anna Sadowska, Marek Pacholczyk, Wojciech Lisik, Magdalena Durlik
AIM OF THE STUDY: Aim of the study was to assess the impact of the recipient and donor interferon lambda-3 (IFNL3) single-nucleotide polymorphisms (SNPs) rs12979860 and rs8099917 on the course of hepatitis C virus (HCV) reinfection following liver transplantation. MATERIAL AND METHODS: The study involved 141 subjects after liver transplantation for HCV-induced cirrhosis, performed between 2000 and 2015. It assessed the impact of both SNPs on the outcomes of interferon/ribavirin (IFN/RBV) treatment following transplantation, HCV viral load, laboratory test results, histological lesions in the liver graft, the risk of acute rejection, and the development of hepatocellular carcinoma (HCC) in patient's own liver...
September 2017: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29040985/serum-ifn-%C3%AE-3-levels-correlate-with-serum-hepatitis-c-virus-rna-levels-in-symptomatic-patients-with-acute-hepatitis-c
#18
MULTICENTER STUDY
Susumu Imoto, Soo Ryang Kim, Keisuke Amano, Etsuko Iio, Seitetsu Yoon, Shigeya Hirohata, Yoshihiko Yano, Toru Ishikawa, Shinji Katsushima, Toshiki Komeda, Toyokazu Fukunaga, Hobyung Chung, Hiroyuki Kokuryu, Yutaka Horie, Takashi Hatae, Aya Fujinami, Soo Ki Kim, Masatoshi Kudo, Yasuhito Tanaka
BACKGROUND: Recent genome-wide association studies demonstrated that 2 single nucleotide polymorphisms (SNPs), upstream of the interferon-λ (IFNL) 3 gene, are associated with the spontaneous clearance of hepatitis C virus (HCV) in symptomatic patients with acute hepatitis C (AHC). Although these 2 SNPs, rs8099917 and rs12979860, have established their significant roles in the innate immunity response to spontaneously clear HCV in patients with AHC, the detailed mechanisms of their roles remain largely unknown...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29022122/association-of-interferon-lambda-polymorphisms-with-elevated-baseline-viral-loads-in-chronic-hepatitis-c-virus-genotype-6-infection
#19
Linh Thuy Nguyen, Dzung Van Nguyen, Michael J Carr, William W Hall, Lan Anh Nguyen
Globally, hepatitis C virus (HCV) is one of the major causes of hepatocellular carcinoma and liver cirrhosis. For clinical decision making, genetic variation in the interferon-λ (IFNL) cluster has been utilised as a baseline predictor of natural and interferon-based treatment-induced viral clearance. In Vietnam, where HCV genotypes 1 (g1) and g6 predominate, no prior studies have been conducted investigating associations of IFNL3/4 polymorphisms with spontaneous clearance (SC) or HCV viral load (VL) in chronic infection...
January 2018: Archives of Virology
https://www.readbyqxmd.com/read/28984602/modulation-of-immune-responses-to-herpes-simplex-virus-type-1-by-ifnl3-and-irf7-polymorphisms-a-study-in-alzheimer-s-disease
#20
Andrea Saul Costa, Simone Agostini, Franca Rosa Guerini, Roberta Mancuso, Milena Zanzottera, Enrico Ripamonti, Vittorio Racca, Raffaello Nemni, Mario Clerici
Herpes simplex virus type 1 (HSV-1) has long been suspected to play a role in Alzheimer's disease (AD), the most common form of dementia. IFN-lambda (IFN-λ) is one of the key cytokine in innate antiviral defenses and, in particular, has an appreciable antiviral activity against HSV-1 infection. IFN-λ expression is regulated by the interaction between two different proteins: Mediator Complex 23 (MED23) and Interferon-Responsive Transcription Factor 7 (IRF7); single nucleotide polymorphisms (SNPs) in these genes as well as in IFNL3 were shown to be differently distributed in AD patients...
2017: Journal of Alzheimer's Disease: JAD
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