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NFAT5 or TonEBP or OREBP

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https://www.readbyqxmd.com/read/30310263/activator-protein-1-contributes-to-the-nacl-induced-expression-of-vegf-and-plgf-in-rpe-cells
#1
Jana Kleiner, Margrit Hollborn, Peter Wiedemann, Andreas Bringmann
Purpose: Systemic hypertension is a risk factor of neovascular age-related macular degeneration; consumption of dietary salt resulting in extracellular hyperosmolarity is a main cause of hypertension. Extracellular hyperosmolarity was shown to induce expression of angiogenic growth factors, such as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), in RPE cells. The aim of the present study was to determine whether the hyperosmotic expression of growth factor genes in RPE cells is mediated by activator protein-1 (AP-1), and whether c-Fos and c-Jun genes are regulated by extracellular osmolarity...
2018: Molecular Vision
https://www.readbyqxmd.com/read/30293684/nfat5-promotes-in-vivo-development-of-murine-melanoma-metastasis
#2
Dong-Ho Kim, Kye-Seong Kim, Suresh Ramakrishna
Malignant melanoma is one of the most fatal and aggressive skin cancers, originating from pigment-containing melanocytes. Despite progress in clinical research, treatment options for malignant melanoma have been limited. The nuclear factor of activated T-cell 5 (NFAT5), originally identified as tonicity regulated transcription factor Ton/EBP, is now known as a carcinogenic gene in several types of cancer pathology. In this study, we knocked down NFAT5 to investigate its role in melanoma cancer. shRNA-mediated knockdown of NFAT5 led to a significant decrease in cell proliferation in vitro...
October 4, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30279231/loss-of-rbms3-confers-platinum-resistance-in-epithelial-ovarian-cancer-via-activation-of-mir-126-5p-%C3%AE-catenin-cbp-signaling
#3
Geyan Wu, Lixue Cao, Jinrong Zhu, Zhanyao Tan, Miaoling Tang, Ziwen Li, Yameng Hu, Ruyuan Yu, Shuxia Zhang, Libing Song, Jun Li
PURPOSE: The development of resistance to platinum-based chemotherapy remains the unsurmountable obstacle in cancer treatment and consequently leads to tumor relapse. This study aims to investigate the mechanism by which loss of RBMS3 induced chemoresistance in epithelial ovarian cancer (EOC). EXPERIMENTAL DESIGN: Fluorescence in situ hybridization and immunochemistry were used to determine deletion frequency and expression of RBMS3 in 15 clinical EOC tissues and 150 clinicopathologically characterized EOC specimens...
October 2, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30271888/analgesia-linked-to-nav1-7-loss-of-function-requires-%C3%A2%C2%B5-and-%C3%AE-opioid-receptors
#4
Vanessa Pereira, Queensta Millet, Jose Aramburu, Cristina Lopez-Rodriguez, Claire Gaveriaux-Ruff, John N Wood
Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state. We have used pharmacological and genetic approaches to identify the opioid receptors involved in this form of analgesia. We also examined the regulation of proenkephalin expression by the transcription factor Nfat5 that binds upstream of the Penk gene. Methods: We used specific µ-, δ- and κ-opioid receptor antagonists alone or in combination to examine which opioid receptors were necessary for Nav1...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/30243440/search-for-upstream-cell-volume-sensors-the-role-of-plasma-membrane-and-cytoplasmic-hydrogel
#5
Sergei N Orlov, Aleksandra Shiyan, Francis Boudreault, Olga Ponomarchuk, Ryszard Grygorczyk
The plasma membrane plays a prominent role in the regulation of cell volume by mediating selective transport of extra- and intracellular osmolytes. Recent studies show that upstream sensors of cell volume changes are mainly located within the cytoplasm that displays properties of a hydrogel and not in the plasma membrane. Cell volume changes occurring in anisosmotic medium as well as in isosmotic environment affect properties of cytoplasmic hydrogel that, in turn, trigger rapid regulatory volume increase and decrease (RVI and RVD)...
2018: Current Topics in Membranes
https://www.readbyqxmd.com/read/30232334/roquin-targets-mrnas-in-a-3-utr-specific-manner-by-different-modes-of-regulation
#6
Katharina Essig, Nina Kronbeck, Joao C Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan, Vigo Heissmeyer
The RNA-binding proteins Roquin-1 and Roquin-2 redundantly control gene expression and cell-fate decisions. Here, we show that Roquin not only interacts with stem-loop structures, but also with a linear sequence element present in about half of its targets. Comprehensive analysis of a minimal response element of the Nfkbid 3'-UTR shows that six stem-loop structures cooperate to exert robust and profound post-transcriptional regulation. Only binding of multiple Roquin proteins to several stem-loops exerts full repression, which redundantly involved deadenylation and decapping, but also translational inhibition...
September 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/30221680/hyperosmotic-stress-stimulates-autophagy-via-the-nfat5-mtor-pathway-in-cardiomyocytes
#7
Hong Zhu, Wei Cao, Peng Zhao, Jieyu Wang, Yuying Qian, Yun Li
Hyperosmotic stress may be initiated during a diverse range pathological circumstances, which in turn results in tissue damage. In this process, the activation of survival signaling, which has the capacity to restore cell homeostasis, determines cell fate. Autophagy is responsible for cell survival and is activated by various pathological stimuli. However, its interplay with hyperosmotic stress and its effect on terminally differentiated cardiac myocytes is unknown. Nuclear factor of activated T‑cells 5 (NFAT5), an osmo‑sensitive transcription factor, mediates the expression of cell survival associated‑genes under hyperosmotic conditions...
September 12, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30216339/activating-pax-gene-family-paralogs-to-complement-pax5-leukemia-driver-mutations
#8
Matthew R Hart, Donovan J Anderson, Christopher C Porter, Tobias Neff, Michael Levin, Marshall S Horwitz
PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous inactivating mutations of PAX5 in malignant cells, and heterozygous germline loss-of-function PAX5 mutations cause autosomal dominant predisposition to ALL. At least in mice, Pax5 is required for pre-B cell maturation, and leukemic remission occurs when Pax5 expression is restored in a Pax5-deficient mouse model of ALL...
September 2018: PLoS Genetics
https://www.readbyqxmd.com/read/30190682/nfat5-isoform-c-controls-biomechanical-stress-responses-of-vascular-smooth-muscle-cells
#9
Maren Zappe, Anja Feldner, Caroline Arnold, Carsten Sticht, Markus Hecker, Thomas Korff
Vascular cells are continuously exposed to mechanical stress that may wreak havoc if exceeding physiological levels. Consequently, mechanisms facing such a challenge are indispensable and contribute to the adaptation of the cellular phenotype. To this end, vascular smooth muscle cells (VSMCs) activate mechanoresponsive transcription factors promoting their proliferation and migration to initiate remodeling the arterial wall. In mechanostimulated VSMCs, we identified nuclear factor of activated T-cells 5 (NFAT5) as transcriptional regulator protein and intended to unravel mechanisms controlling its expression and nuclear translocation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30184542/mir-338-5p-regulates-the-viability-proliferation-apoptosis-and-migration-of-rheumatoid-arthritis-fibroblast-like-synoviocytes-by-targeting-nfat5
#10
Ting Guo, Hao Ding, Hui Jiang, Nirong Bao, Liwu Zhou, Jianning Zhao
BACKGROUND/AIMS: MicroRNAs (miRNAs) have been reported to be involved in Rheumatoid arthritis (RA) pathogenesis and prognosis. However, little is known about the disease mechanism in RA. Here, we aim to investigate the potential association between miR-338-5p and NFAT5 in RA. METHODS: Aberrant expression of miR-338-5p in RA tissues and rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs) compared to the normal were determined by RT-qPCR. Cell viability was determined using the CCK-8 assay, and cell apoptosis was analyzed via Annexin V-FITC/PI double staining and was detected using flow cytometry...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30090015/osmotic-and-hypoxic-induction-of-the-complement-factor-c9-in-cultured-human-retinal-pigment-epithelial-cells-regulation-of-vegf-and-nlrp3-expression
#11
Margrit Hollborn, Charlotte Ackmann, Heidrun Kuhrt, Fabian Doktor, Leon Kohen, Peter Wiedemann, Andreas Bringmann
Purpose: Variants of complement factor genes, hypoxia and oxidative stress of the outer retina, and systemic hypertension affect the risk of age-related macular degeneration. Hypertension often results from the high intake of dietary salt that increases extracellular osmolarity. We determined the effects of extracellular hyperosmolarity, hypoxia, and oxidative stress on the expression of complement genes in cultured (dedifferentiated) human RPE cells and investigated the effects of C9 siRNA and C9 protein on RPE cells...
2018: Molecular Vision
https://www.readbyqxmd.com/read/30009821/altered-expression-of-aquaporin-2-in-one-kidney-one-clip-hypertension
#12
Maria Florencia Albertoni Borghese, Sandra Hope, Maria Del Carmen Ortiz, Magalí Barchuk, Camila Kessler, Carlos Davio, Marcelo Vatta, Mónica Majowicz
AIMS: The aim of the present study was to evaluate the regulation of Aquaporin-2 (AQP2) water channel in the kidney of one-kidney, one-clip rats (Goldblatt-1 model). In addition, some mechanisms that underlie the role of AQP2 in the Goldblatt-1 model were evaluated. MAIN METHODS: Sprague-Dawley rats were divided in three groups: control two-kidney, no clip (C, 2 K-NC); nephrectomized one-kidney, no clip (N, 1 K-NC) and Goldblatt one-kidney, one-clip (G, 1 K-1C)...
September 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29888131/pro-inflammatory-age-rage-signaling-is-activated-during-arousal-from-hibernation-in-ground-squirrel-adipose
#13
Samantha M Logan, Kenneth B Storey
Background: Inflammation is generally suppressed during hibernation, but select tissues (e.g. lung) have been shown to activate both antioxidant and pro-inflammatory pathways, particularly during arousal from torpor when breathing rates increase and oxidative metabolism fueling the rewarming process produces more reactive oxygen species. Brown and white adipose tissues are now understood to be major hubs for the regulation of immune and inflammatory responses, yet how these potentially damaging processes are regulated by fat tissues during hibernation has hardly been studied...
2018: PeerJ
https://www.readbyqxmd.com/read/29847776/suppression-of-pax2-attenuates-allodynia-and-hyperalgesia-through-et-1-etar-nfat5-signaling-in-a-rat-model-of-neuropathic-pain
#14
Lydia Wai Tai, Zhiqiang Pan, Liting Sun, Haobo Li, Pan Gu, Stanley Sau Ching Wong, Sookja K Chung, Chi Wai Cheung
Endothelin-1 (ET-1) and its receptors (ETAR/ETBR) emerge to be a key signaling axis in neuropathic pain processing and are recognized as new therapeutic targets. Yet, little is known on the functional regulation of ET-1 axis during neuropathic pain. Bioinformatics analysis indicated that paired box gene 2 (Pax2) or nuclear factor of activated T-cells 5 (NFAT5), two transcription factors involved in the modulation of neurotransmission, may regulate ET-1. Therefore, we hypothesized that ET-1 axis may be regulated by Pax2 or NFAT5 in the development of neuropathic pain...
August 1, 2018: Neuroscience
https://www.readbyqxmd.com/read/29794013/transcription-factor-nfat5-promotes-migration-and-invasion-of-rheumatoid-synoviocytes-via-coagulation-factor-iii-and-ccl2
#15
Saseong Lee, Jin-Sun Kong, Sungyong You, H Moo Kwon, Seung-Ah Yoo, Chul-Soo Cho, Wan-Uk Kim
Fibroblast-like synoviocytes (FLSs) play a key role in the progression of rheumatoid arthritis (RA) as a primary component of invasive hypertrophied pannus. FLSs of RA patients (RA-FLSs) exhibit cancer-like features, including promigratory and proinvasive activities that largely contribute to joint cartilage and bone destruction. In this study, we hypothesized that the NF of activated T cell 5 (NFAT5), a transcription factor involving tumor invasiveness, would control the migration and invasion of RA-FLSs. Analyses of transcriptomes demonstrated the significant involvement of NFAT5 in locomotion of RA-FLSs and that tissue factor (TF; also known as coagulation factor III) and CCL2 were the major downstream target genes of NFAT5 involving FLS migration and invasion...
July 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29739889/farnesoid-x-receptor-is-essential-for-the-survival-of-renal-medullary-collecting-duct-cells-under-hypertonic-stress
#16
Sujuan Xu, Shizheng Huang, Zhilin Luan, Tingyue Chen, Yuanyi Wei, Miaomiao Xing, Yaqing Li, Chunxiu Du, Bing Wang, Feng Zheng, Nanping Wang, Youfei Guan, Jan-Åke Gustafsson, Xiaoyan Zhang
Hypertonicity in renal medulla is critical for the kidney to produce concentrated urine. Renal medullary cells have to survive high medullary osmolarity during antidiuresis. Previous study reported that farnesoid X receptor (FXR), a nuclear receptor transcription factor activated by endogenous bile acids, increases urine concentrating ability by up-regulating aquaporin 2 expression in medullary collecting duct cells (MCDs). However, whether FXR is also involved in the maintenance of cell survival of MCDs under dehydration condition and hypertonic stress remains largely unknown...
May 22, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29700115/cox-2-expression-mediated-by-calcium-tonebp-signaling-axis-under-hyperosmotic-conditions-serves-osmoprotective-function-in-nucleus-pulposus-cells
#17
Hyowon Choi, Weera Chaiyamongkol, Alexandra C Doolittle, Zariel I Johnson, Shilpa S Gogate, Zachary R Schoepflin, Irving M Shapiro, Makarand V Risbud
The nucleus pulposus (NP) of intervertebral discs experiences dynamic changes in tissue osmolarity because of diurnal loading of the spine. TonEBP/NFAT5 is a transcription factor that is critical in osmoregulation as well as survival of NP cells in the hyperosmotic milieu. The goal of this study was to investigate whether cyclooxygenase-2 (COX-2) expression is osmoresponsive and dependent on TonEBP, and whether it serves an osmoprotective role. NP cells up-regulated COX-2 expression in hyperosmotic media. The induction of COX-2 depended on elevation of intracellular calcium levels and p38 MAPK pathway, but independent of calcineurin signaling as well as MEK/ERK and JNK pathways...
June 8, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29661287/prognostic-significance-of-nuclear-factor-of-activated-t-cells-5-expression-in-non-small-cell-lung-cancer-patients-who-underwent-surgical-resection
#18
Hyun Jin Cho, Hwan-Jung Yun, Hee Chul Yang, Soo Jin Kim, Shin Kwang Kang, Chengri Che, Sang Do Lee, Min-Woong Kang
BACKGROUND: Nuclear factor of activated T-cells 5 (NFAT5) is known to be correlated with migration or invasion of tumor cells based on previous in vitro studies. The aim of this study was to analyze the relationship between NFAT5 expression and clinical prognosis in non-small cell lung cancer (NSCLC) patients who underwent surgical resection. MATERIALS AND METHODS: A total of 92 NSCLC patients who underwent surgical resection were enrolled. The tissue microarray core was obtained from surgically resected tumor specimens...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29546053/-positive-regulation-of-rna-metabolic-process-ontology-group-highly-regulated-in-porcine-oocytes-matured-in-vitro-a-microarray-approach
#19
Piotr Celichowski, Mariusz J Nawrocki, Marta Dyszkiewicz-Konwińska, Maurycy Jankowski, Joanna Budna, Artur Bryja, Wiesława Kranc, Sylwia Borys, Sandra Knap, Sylwia Ciesiółka, Michal Jeseta, Karolina Piasecka-Stryczyńska, Ronza Khozmi, Dorota Bukowska, Paweł Antosik, Klaus P Brüssow, Małgorzata Bruska, Michał Nowicki, Maciej Zabel, Bartosz Kempisty
The cumulus-oocyte complexes (COCs) growth and development during folliculogenesis and oogenesis are accompanied by changes involving synthesis and accumulation of large amount of RNA and proteins. In this study, the transcriptomic profile of genes involved in "oocytes RNA synthesis" in relation to in vitro maturation in pigs was investigated for the first time. The RNA was isolated from oocytes before and after in vitro maturation (IVM). Interactions between differentially expressed genes/proteins belonging to "positive regulation of RNA metabolic process" ontology group were investigated by STRING10 software...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29515464/localization-and-expression-of-nuclear-factor-of-activated-t-cells-5-in-myoblasts-exposed-to-pro-inflammatory-cytokines-or-hyperosmolar-stress-and-in-biopsies-from-myositis-patients
#20
Sandrine Herbelet, Elly De Vlieghere, Amanda Gonçalves, Boel De Paepe, Karsten Schmidt, Eline Nys, Laurens Weynants, Joachim Weis, Gert Van Peer, Jo Vandesompele, Jens Schmidt, Olivier De Wever, Jan L De Bleecker
Aims: Regeneration in skeletal muscle relies on regulated myoblast migration and differentiation, in which the transcription factor nuclear factor of activated T-cells 5 (NFAT5) participates. Impaired muscle regeneration and chronic inflammation are prevalent in myositis. Little is known about the impact of inflammation on NFAT5 localization and expression in this group of diseases. The goal of this study was to investigate NFAT5 physiology in unaffected myoblasts exposed to cytokine or hyperosmolar stress and in myositis...
2018: Frontiers in Physiology
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