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Lymph node counting

Ana Rafaela Luz de Aquino Martins, Hellen Bandeira de Pontes Santos, Rodrigo Porpino Mafra, Cassiano Francisco Weege Nonaka, Lélia Batista de Souza, Leão Pereira Pinto
This study evaluated the lymphatic density and HIF-1α immunoexpression in lower lip squamous cell carcinoma (LLSCC) and their correlation with clinicopathological (nodal metastasis, clinical stage, histological grade, recurrence and disease outcome) and survival parameters in 20 metastatic and 20 non-metastatic LLSCCs. Lymphatic density was established by counting microvessels (D2-40+ ) at the tumor core (intratumoral lymphatic density, ILD) and at the invasive front (peritumoral lymphatic density, PLD) and percentages of immunopositive cells for HIF-1α were established...
July 29, 2018: Journal of Cranio-maxillo-facial Surgery
Amanda Gubert Alves Dos Santos, Lainy Leiny de Lima, Camila Alves Mota, Marcelo Biondaro Gois, Andrea Claudia Bekner Silva Fernandes, Thaís Gomes Verzignassi Silveira, Debora de Mello Gonçales Sant'Ana, Gessilda de Alcântara Nogueira de Melo
AIM: The present study compared and evaluated morphological and quantitative alterations in the ileum of hamsters infected by two L. (V.) braziliensis strains isolated from patients with different lesion aspects and treatment responses. MAIN METHODS: Hamsters were infected in the left hindpaw with a suspension of promastigotes (2 × 107 /100 μl) of two different strains of L. (V.) braziliensis. After 90 or 120 days, the animals were euthanized. Samples of the ileum and mesenteric lymph node were collected for histological examination and quantitative polymerase chain reaction...
July 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ning Zhang, Li Zuo, Hong Zheng, Gang Li, Xichun Hu
BACKGROUND CD81, a member of the tetraspanin family, is overexpressed in several tumor types, but its role in breast cancer remains unknown. The present study aimed to investigate the effects of increased CD81 expression on cell migration and proliferation in breast cancer cell lines, MDA-MB-231 and MDA-MB-435S in vitro, and the effects of increased CD81 expression in breast cancer tissue microarrays on patient prognosis. MATERIAL AND METHODS The expression of CD81 was evaluated using immunohistochemistry in a human breast cancer tissue microarray containing 140 tumor tissues and a microarray containing 77 normal breast tissues...
August 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Paula Cramer, Julia von Tresckow, Jasmin Bahlo, Sandra Robrecht, Petra Langerbeins, Othman Al-Sawaf, Anja Engelke, Anna-Maria Fink, Kirsten Fischer, Eugen Tausch, Till Seiler, Ludwig Fischer von Weikersthal, Holger Hebart, Karl-Anton Kreuzer, Sebastian Böttcher, Matthias Ritgen, Michael Kneba, Clemens-Martin Wendtner, Stephan Stilgenbauer, Barbara Eichhorst, Michael Hallek
BACKGROUND: Targeted agents such as the type II anti-CD20 antibody obinutuzumab and the B-cell lymphoma-2 antagonist venetoclax have shown impressive therapeutic activity in chronic lymphocytic leukaemia. The CLL2-BAG trial was initiated to investigate the combination of these two agents in patients with chronic lymphocytic leukaemia. METHODS: In this ongoing multicentre, open-label, investigator-initiated phase 2 trial, patients (aged ≥18 years) with chronic lymphocytic leukaemia requiring treatment according to the 2008 International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria and an Eastern Cooperative Oncology Group performance status of 0-2 were enrolled at 16 sites in Germany...
August 13, 2018: Lancet Oncology
Stanley P Leong, Max Wu, Ying Lu, Donald M Torre, Anna von Bakonyi, Arianna M Ospina, James D Newsom, William S Luckett, Christopher W Soon, Kevin B Kim, Mohammed Kashani-Sabet
BACKGROUND: Preoperative imaging and intraoperative gamma probe (GP) localization is standard for identifying sentinel lymph nodes (SLNs) in melanoma patients. The aim of this prospective Institutional Review Board-approved study was to investigate whether an intraoperative portable gamma camera (PGC) improves SLN detection over the GP. METHODS: Lymphoscintigraphy and single photon emission computed tomography/computed tomography were performed after injection of 99mTc-Tilmanocept in melanoma patients (≥ 18 years, Breslow thickness ≥ 1...
August 13, 2018: Annals of Surgical Oncology
Peter Ulrich, Thierry Flandre, Pascal Espie, Denise Sickert, Tina Rubic-Schneider, David A Shaw, James S Rush
CFZ533 is a pathway blocking, non-depleting anti-CD40 antibody that is in clinical development for inhibition of transplant organ rejection and therapy for autoimmune diseases. A 26-week GLP toxicity study in sexually mature Cynomolgus monkeys was conducted in order to support chronic application of CFZ533. CFZ533 was subcutaneously administered at doses up to 150 mg/kg/week and was safe and generally well tolerated. CFZ533 showed no adverse effects for cardiovascular, respiratory and neurobehavioral endpoints, and no changes were observed for blood lymphocyte and platelet counts or blood coagulation markers...
August 7, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Fatma Abd-Elshahed Abd-Elhay, Khaled Mosaad Elhusseiny, Mohamed Gomaa Kamel, Soon Khai Low, To Kim Sang, Ghaleb Muhammad Mehyar, Le Huu Nhat Minh, Mohammad Rashidul Hashan, Nguyen Tien Huy
BACKGROUND: Male breast cancer (MBC) is usually diagnosed at late stages and therefore has a worse prognosis than female breast cancer (FBC). MBC is also more likely to have lymph node (LN) involvement than FBC. MATERIALS AND METHODS: We sought to determine the prognostic role of the examined lymph node (LN), negative LN (NLN), and positive LN counts and the LN ratio (LNR), defined as (positive LNs/ENLs), on the survival rate among MBC patients. We performed a large population-based study using the data from the Surveillance, Epidemiology, and End Results program...
July 7, 2018: Clinical Breast Cancer
Sofia Garces, Joseph D Khoury, Rashmi Kanagal-Shamanna, Alireza Salem, Sa A Wang, Chi Young Ok, Shimin Hu, Keyur P Patel, Mark J Routbort, Rajyalakshmi Luthra, Guilin Tang, Ellen J Schlette, Carlos E Bueso-Ramos, L Jeffrey Medeiros, Sanam Loghavi
The presence of expanded proliferation centers (PCs) in lymph nodes involved by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has been associated with adverse clinical outcomes, but the frequency and significance of PCs in bone marrow (BM) remains unclear. The study group included 36 patients with BM involvement by CLL in which PCs were present. We compared this group with 110 randomly selected BM samples involved by CLL without morphologically discernable PCs. Patients with PCs in BM were younger (median age, 53years [range,18-71] versus 58years [range, 31-82]; P=...
August 4, 2018: Human Pathology
M A O'Brien, M A McMichael, K Le Boedec
BACKGROUND: Hypovitaminosis D is common in humans with tuberculosis, and adequate serum 25-hydroxyvitamin D [25(OH)D] concentrations may improve response to therapy. The pathomechanism of Blastomyces dermatitidis is similar to that of Mycobacterium tuberculosis, but the 25(OH)D status of dogs with blastomycosis has not been investigated. OBJECTIVES: To determine if dogs with blastomycosis have lower 25(OH)D concentrations compared with healthy controls and to explore the prognostic value of 25(OH)D concentrations in blastomycosis...
August 5, 2018: Journal of Veterinary Internal Medicine
Nandini Krishnamoorthy, David N Douda, Thayse R Brüggemann, Isabell Ricklefs, Melody G Duvall, Raja-Elie E Abdulnour, Kimberly Martinod, Luciana Tavares, Xiao Wang, Manuela Cernadas, Elliot Israel, David T Mauger, Eugene R Bleecker, Mario Castro, Serpil C Erzurum, Benjamin M Gaston, Nizar N Jarjour, Sally Wenzel, Eleanor Dunican, John V Fahy, Daniel Irimia, Denisa D Wagner, Bruce D Levy
Severe asthma is a debilitating and treatment refractory disease. As many as half of these patients have complex neutrophil-predominant lung inflammation that is distinct from milder asthma with type 2 eosinophilic inflammation. New insights into severe asthma pathogenesis are needed. Concomitant exposure of mice to an aeroallergen and endotoxin during sensitization resulted in complex neutrophilic immune responses to allergen alone during later airway challenge. Unlike allergen alone, sensitization with allergen and endotoxin led to NETosis...
August 3, 2018: Science Immunology
Danielle Mann, Flávia Marinho Sant'Anna, Carolina Arana Stanis Schmaltz, Dayvison Francis Saraiva Freitas, Valeria Cavalcanti Rolla, Solange Cesar Cavalcante, Maria Clara Gutierrez-Galhardo
BACKGROUND: Cutaneous tuberculosis (CTB) is a rare extrapulmonary form of tuberculosis (TB). Despite the increase in the number of cases of TB and HIV, few cases of CTB have been reported. OBJECTIVE: To describe CTB cases among patients with HIV infection from a cohort with tuberculosis. METHODS: We describe a series of 15 CTB and HIV cases, based on secondary data from 2000 to 2016. Diagnosis was based on isolation of Mycobacterium tuberculosis in culture or clinical response to anti-tuberculous treatment associated with positive smear or histopathologic findings from affected skin or an adjacent lymph node...
July 26, 2018: Memórias do Instituto Oswaldo Cruz
Dao-Ning Liu, Zhong-Wu Li, Hai-Yue Wang, Min Zhao, Wei Zhao, Chun-Yi Hao
Rationale: To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. To analyze the predictive value of 18F-FDG-PET/CT for histological grade and main prognostic factors. Methods: 195 patients with 44 different diseases have been included. Relationship between SUVmax, Clinical, pathological, and prognostic information has been analyzed. Results: Malignant tumors do not show higher SUVmax than benign ones ( P =0...
2018: Contrast Media & Molecular Imaging
Ed Carlos Rey Moura, Plinio da Cunha Leal, Izabel Cristina Portela Bogéa Serra, Bruno de Paulo Ribeiro, Johnny Ramos do Nascimento, Flavia Raquel Fernandes do Nascimento, Rioko Kimiko Sakata
OBJECTIVE: The objective of this study was to analyze whether duloxetine influences tumor growth in Ehrlich carcinoma. The mice were administered 5 or 30 mg/kg of duloxetine or saline solution. All animals were inoculated with tumor cells. The tumor progression was evaluated by body weight, abdominal circumference, ascites volume and tumor cell count. The effect of duloxetine on immune response was evaluated by lymphoid cells, nitric oxide (NO) production, arginase and superoxide dismutase (SOD) activity and the spleen immunophenotyping...
July 31, 2018: BMC Research Notes
Linming Fang, Huaying Sheng, Danying Wan, Chihong Zhu, Ruibin Jiang, Xiaojiang Sun, Jianguo Feng
The overall survival rate of patients with non-small cell lung cancer (NSCLC) following resection remains poor due to the high rates of recurrence and metastasis. The investigation of novel biomarkers is clinically necessary to improve treatment strategies. Multidrug resistance-associated protein 1 (MRP1) and platelet count are linked to a poor prognosis in various types of cancer. However, it is unknown whether MRP1 or platelet count is a suitable prognostic indicator of NSCLC. In the present study, 427 patients with operable NSCLC were enlisted...
July 2018: Oncology Letters
Usman Maqsood, Muhammad Badar Ganaie, Muhammad Imran Hasan, Mohammed Munavvar
We present a case of bilateral haemotympanum (HT) during endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TBNA). A 64 year-old-man underwent EBUS-TBNA for mediastinal lymph nodes (LN) staging. Medical history included emphysema and angina. Medication included aspirin until the day before procedure. Full blood count and clotting screen were normal. He received sedation (5 mg midazolam, 1000 mcg alfentanil) and topical anaesthesia (16 mL 1% lignocaine) but coughed excessively throughout the procedure...
July 30, 2018: BMJ Case Reports
Pedro Sánchez, Virginia Meca-Lallana, José Vivancos
BACKGROUND AND OBJECTIVE: Fingolimod is a sphingosine 1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes and prevents them from entering the central nervous system. There have been increasing reports of severe rebounds with tumefactive demyelinatinglesions (TDLs) in patients with multiple sclerosis under fingolimod treatment, as well as following therapy discontinuation. Our objective is to review the clinico-radiological characteristics of patients with TDLs associated with fingolimod...
July 19, 2018: Multiple Sclerosis and related Disorders
Jang Jin Kim, Sung Su Park, Taek-Gu Lee, Ho-Chang Lee, Sang-Jeon Lee
Colorectal large-cell neuroendocrine carcinomas (NECs) are extremely rare and have very poor prognosis compared to adenocarcinomas. A 74-year-old man presented with abdominal pain, diarrhea and hematochezia. The histopathologic report of colonoscopic biopsy performed at a local clinic was a poorly differentiated carcinoma. An abdominopelvic computed scan revealed irregularly enhanced wall thickening at the sigmoid colon with regional fat stranding and lymphnode enlargement. He underwent a laparoscopic high anterior resection with selective peritonectomy for peritoneal carcinomatosis, intraoperative peritoneal irrigation chemotherapy, and early postoperative intraperitoneal chemotherapy for 5 days...
July 26, 2018: Annals of Coloproctology
Wilko Thiele, Melanie Rothley, Arno Dimmler, Peter Bugert, Carla Salomó Coll, Jonathan P Sleeman
Platelets are thought to play an important role in metastasis formation, although the mechanisms involved remain incompletely understood. Here we studied the influence of platelet numbers on organ-specific metastasis to the lungs and lymph nodes using Tpo deficient mice that have low platelet counts. After tail vein injection of 4T1 breast cancer cells, the number of lung metastases was significantly lower in Tpo-/- mice compared to Tpo+/+ mice. The same was true for the bone-tropic 4T1.2 derivative. In spontaneous orthotopic metastasis assays, 4T1 and 4T1...
July 24, 2018: Clinical & Experimental Metastasis
Francesco Sopracordevole, Nicolò Clemente, Giorgio Giorda, Vincenzo Canzonieri, Lara Alessandrini, Anna Del Fabro, Matteo Serri, Andrea Ciavattini
AIM: The aim of this study was to evaluate if the lymph node count from inguinofemoral lymphadenectomy impacted the risk of isolated groin recurrence in patients with node-negative squamous cell vulvar cancer. MATERIALS AND METHODS: This is a retrospective cohort study of women with squamous cell vulvar cancer (stage IB-II according to the 2009 Revised International Federation of Gynecology and Obstetrics staging system) who underwent primary radical vulvar surgery and groin lymphadenectomy between January 2005 and December 2014...
July 20, 2018: International Journal of Gynecological Cancer
Hongjie Sun, Dongli Huang, Guozheng Liu, Fengguo Jian, Jianfang Zhu, Lixia Zhang
Background: Previous study has proven that SIRT4 is downregulated in gastric cancer (GC), but the role of SIRT4 has not been clearly understood. The aim of our work was to explore in detail the function and mechanism of SIRT4 in GC. Methods: A total of 86 pairs of GC tumor tissues and adjacent normal tissues were collected, and quantitative real-time polymerase chain reaction and Western blotting analyses were used to determine the expression of SIRT4. Results: Our study revealed that the expression of SIRT4 was downregulated in GC tissues and cells...
2018: OncoTargets and Therapy
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