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https://www.readbyqxmd.com/read/30536753/extent-of-lateral-neck-dissection-for-papillary-thyroid-microcarcinomas
#1
Joon-Hyop Lee, Yong Soon Chun, Yoo Seung Chung
BACKGROUND: Papillary thyroid microcarcinomas (PTMCs) often demonstrate lateral lymph node (LN) metastasis. The purpose of this study was to assess whether the size of primary tumor should be considered in deciding lateral neck dissection extent. METHODS: We conducted a retrospective comparison of patients with PTMC and papillary thyroid carcinoma (PTC) larger than 1 cm who received lateral LN dissection from 2009 to 2015. RESULTS: PTMC group had more frequent metachronous metastasis, multifocality, less involvement of lower third thyroid, lower metastatic central LN counts and ratio, and lower metastatic total LN ratio...
December 10, 2018: Head & Neck
https://www.readbyqxmd.com/read/30536320/lncrna-snhg7-promotes-development-of-breast-cancer-by-regulating-microrna-186
#2
X Luo, Y Song, L Tang, D-H Sun, D-G Ji
OBJECTIVE: To elucidate the biological functions of long non-coding RNA (lncRNA) SNHG7 in breast cancer (BC), and its underlying mechanism in the occurrence and progression of BC. PATIENTS AND METHODS: The expression of SNHG7 in 72 pairs of BC tissues and paracancerous tissues was detected by quantitative Real-time polymerase chain reaction (qRT-PCR). Correlation between SNHG7 expressions with pathological indicators of BC patients was analyzed. Similarly, SNHG7 expression in BC cell lines was determined by qRT-PCR as well...
November 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30536306/downregulation-of-mir-1294-associates-with-prognosis-and-tumor-progression-in-epithelial-ovarian-cancer
#3
T-Y Guo, H-Y Xu, W J Chen, M-X Wu, X Dai
OBJECTIVE: Increasing evidence has revealed that microRNAs (miRNAs) act as key players in the regulation of tumor growth and metastasis in epithelial ovarian cancer (EOC). However, the clinical role and functional effects of miR-1294 in EOC remain unknown. PATIENTS AND METHODS: We examined the expression of miR-1294 in 69 cases of EOC tissues and cell lines by quantitative Real-time polymerase chain reaction (qRT-PCR). The associations of miR-1294 expression with clinicopathologic features and overall survival of EOC patients were analyzed...
November 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30535480/downregulation-of-mir-95-in-gastric-cancer-promotes-emt-via-regulation-of-slug-thereby-promoting-migration-and-invasion
#4
Wei Zhang, Jing Sun, Jinyan Chen, Caiyun Xu, Lixia Zhang
miR-95 has been revealed to be aberrantly expressed in multiple types of cancer and to regulate tumor development. Moreover, miR-95 has been revealed to be downregulated in gastric cancer. However, the detailed function of miR-95 in gastric cancer has remained largely unknown. In the present study, we found that miR-95 was downregulated in 63 pairs of gastric cancer tissue samples and adjacent normal tissue samples, as well as gastric cancer cell lines. Additionally, the expression of miR-95 was associated with tumor size, tumor‑node‑metastasis (TNM) stage and lymph node metastasis...
December 6, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30527676/comparison-of-retroauricular-and-small-transcervical-approaches-for-endoscopic-assisted-selective-neck-dissection-a-cadaveric-study
#5
S Lee, W Nam
Advances in endoscopic-assisted neck surgery have allowed surgeons to conceal the scars via various approaches. However, studies comparing the approaches are still rare. The aim of this study was to comparatively analyze the feasibility and oncological outcomes of the retroauricular approach (RA) and the small transcervical approach (STC) for endoscopic-assisted selective neck dissection (EASND). Five fresh cadavers were recruited. EASND was performed via RA on one side and via STC on the contralateral side of each of the cadavers...
December 4, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30526290/laparoscopic-d2-gastrectomy-for-gastric-cancer-mid-term-results-and-current-evidence
#6
Andre Roncon Dias, Carlos Eduardo Jacob, Marcus Fernando Kodama Pertille Ramos, Marina Alessandra Pereira, Daniel Jose Szor, Osmar Kenji Yagi, Leandro Cardoso Barchi, Ulysses Ribeiro, Bruno Zilberstein, Ivan Cecconello
INTRODUCTION: Although the first laparoscopic gastrectomy was performed in 1991, there was a long delay until it was incorporated into the regular practice of western surgeons. In Brazil, there are only few case series reported and data on its safety and efficacy along with mid- and long-term results are desired. OBJECTIVE: Present the mid-term results of laparoscopic gastrectomy with curative intent in the treatment of gastric adenocarcinoma and review the current evidence on the therapy of this neoplasia with the laparoscopic access...
December 11, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/30515871/clinicopathological-and-immunological-features-of-follicular-pancreatitis-a-distinct-disease-entity-characterized-by-th17-activation
#7
Hironori Ryota, Mitsuaki Ishida, Sohei Satoi, Hiroaki Yanagimoto, Tomohisa Yamamoto, Hisashi Kosaka, Satoshi Hirooka, So Yamaki, Masaya Kotsuka, Yoichi Matsui, Tsukasa Ikeura, Kazushige Uchida, Makoto Takaoka, Kazuichi Okazaki, Koji Tsuta
AIM: Follicular pancreatitis is a recently recognized, distinct clinicopathological entity characterized by the presence of many intrapancreatic lymphoid follicles with reactive germinal centres. However, the clinicopathological and immunological features and causes have not yet been established. We assessed the clinicopathological and immunological profiles of patients with follicular pancreatitis who underwent surgery. METHODS AND RESULTS: This study included three patients with pancreatic masses (age range: 62-75 years; women:men: 1:2)...
December 4, 2018: Histopathology
https://www.readbyqxmd.com/read/30510850/head-to-head-comparison-performance-of-99m-tc-edda-hynic-ipsma-spect-ct-and-68-ga-psma-11-pet-ct-a-prospective-study-in-biochemical-recurrence-prostate-cancer-patients
#8
Francisco Osvaldo García-Pérez, Jenny Davanzo, Sergio López-Buenrostro, Clara Santos-Cuevas, Guillermina Ferro-Flores, Miguel A Jímenez-Ríos, Anna Scavuzzo, Zael Santana-Ríos, Sevastián Medina-Ornelas
Positron emission tomography (PET) with prostate-specific membrane antigen (PSMA) has found widespread use for the diagnosis of biochemical recurrence of prostate cancer (PCa). Unfortunately, PET/CT is not as widely available; thus a PSMA-targeting compound for scintigraphy is of special interest. The aim of this study was to compare 99m Tc-EDDA/HYNIC-iPSMA and 68 Ga-PSMA-11 PET/CT qualitatively and semi-quantitatively. Twenty-three patients with metastatic PCa were underwent 99m Tc-EDDA/HYNIC-iPSMA SPECT/CT followed by 68 Ga-PSMA-11 PET/CT...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30510459/predictors-of-nodal-metastasis-and-prognostic-significance-of-lymph-node-ratio-and-total-lymph-node-count-in-tracheobronchial-adenoid-cystic-carcinoma
#9
Yang Wo, Shicheng Li, Yuanyong Wang, Tong Lu, Yi Qin, Xiao Sun, Wenjie Jiao
Purpose: To identify potential risk factors of lymph node metastasis and to verify the prognostic significance of the lymph node ratio (LNR) and the total number of lymph nodes examined (NNE) in tracheobronchial adenoid cystic carcinoma (ACC) patients, using a large population-based database. Patients and methods: From Surveillance, Epidemiology, and End Results database, we identified 263 patients with tracheobronchial ACC in whom complete lymph node data could be obtained...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30510359/validation-of-clinical-significance-of-examined-lymph-node-count-for-accurate-prognostic-evaluation-of-gastric-cancer-for-the-eighth-edition-of-the-american-joint-committee-on-cancer-ajcc-tnm-staging-system
#10
Jingyu Deng, Jinyuan Liu, Wei Wang, Zhe Sun, Zhenning Wang, Zhiwei Zhou, Huimian Xu, Han Liang
Objective: To validate the necessity of increasing the examined lymph node (ELN) count for enhancing the accuracy of prognostic evaluation of gastric cancer (GC) patients after curative gastrectomy in multiple medical centers of China. Methods: The clinicopathological data of 7,620 patients who underwent the curative resection for GC between 2001 and 2011 were included to demonstrate whether the ELN count is indispensable for enhancing the accuracy of prognostic evaluation of GC patients after surgery...
October 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30506712/prognostic-evaluation-of-nanog-and-oct4-expression-for-posttransplantation-hepatocellular-carcinoma-recurrence
#11
Wenjuan Cai, Zhenglu Wang, Chunfang Wei, Meng Wu, Weiping Zheng, Haiming Zhang, Chenghu Liu, Lei Liu
Postoperative hepatocellular carcinoma (HCC) recurrence and metastasis throw great threaten to its overall survival (OS). This paper focus on exploring the prognostic significance of NANOG and OCT4 expression in HCC recurrence and OS after liver transplantation. Eighty-six patients who meet University of California San Francisco (UCSF) criteria and underwent liver transplantation in Tianjin First Central Hospital between August 2010 and August 2013 were included. Expression of NANOG and OCT4 was determined by immunohistochemistry...
December 2, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30505600/the-accuracy-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-as-a-marker-for-gastrointestinal-malignancies
#12
Ian Nora, Ravi Shridhar, Jamie Huston, Kenneth Meredith
Background: Accurate predictors of locally advanced and recurrence disease in patients with gastrointestinal cancer are currently lacking. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have emerged as possible markers for predicting recurrence in these patients. In this study, we sought to evaluate the utility of NLR and PLR in predicting the presence of regional nodal disease, metastasis and systemic recurrence in patients with gastrointestinal malignancies...
October 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30496326/tranexamic-acid-decreases-rodent-hemorrhagic-shock-induced-inflammation-with-mixed-end-organ-effects
#13
Patrick F Walker, Anthony D Foster, Philip A Rothberg, Thomas A Davis, Matthew J Bradley
Beyond its anti-fibrinolytic mechanism, tranexamic acid has been suggested to have anti-inflammatory properties which may contribute to the survival benefit it provides to trauma patients. The objective of this study was to assess possible immunomodulatory effects of tranexamic acid as well as potential amelioration of end-organ injury in a rodent hemorrhagic shock model. Controlled hemorrhagic shock was induced in adult Sprague Dawley rats to a mean arterial pressure of 30 mmHg. Groups of 10 rats were administered intravenous tranexamic acid (300mg/kg) or vehicle control (normal saline) intravenously 15 minutes after the induction of shock...
2018: PloS One
https://www.readbyqxmd.com/read/30481787/long-noncoding-rna-fer1l4-suppresses-tumorigenesis-by-regulating-the-expression-of-pten-targeting-mir-18a-5p-in-osteosarcoma
#14
Dan Fei, Xiaona Zhang, Jinxiang Liu, Long Tan, Jie Xing, Dongxu Zhao, Yang Zhang
BACKGROUND/AIMS: Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been reported to play crucial regulatory roles in tumor progression. However, its clinical significance and biological role in osteosarcoma (OS) is completely unknown. The aim of the present study was to investigate the role of FER1L4 in OS progression and the underlying mechanism. METHODS: We analyzed the expression levels of FER1L4 in tissues of OS patients and cell lines via quantitative RT-PCR (qRT-PCR)...
November 27, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30478012/prognostic-significance-of-serum-%C3%AE-glutamyltransferase-in-patients-with-advanced-urothelial-carcinoma
#15
Kosuke Takemura, Hiroshi Fukushima, Masaya Ito, Madoka Kataoka, Yasukazu Nakanishi, Kazumasa Sakamoto, Hiroaki Suzuki, Ken-Ichi Tobisu, Fumitaka Koga
OBJECTIVES: Serum γ-glutamyltransferase (GGT) is reportedly associated with prognosis in patients with various malignancies. However, the prognostic role of GGT is unknown among patients with advanced urothelial carcinoma (aUC). This study was designed to examine the prognostic role of serum GGT in patients with aUC. MATERIALS AND METHODS: Charts of 125 consecutive aUC patients (inoperable cT4 and/or metastasis to lymph nodes/distant organs) managed at a single cancer center between 2004 and 2016 were retrospectively reviewed...
November 24, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/30477622/-clinical-features-of-children-with-kawasaki-disease-aged-over-5-years
#16
Fang Tian, Jing Zhang, Lan Xiao
OBJECTIVE: To study the clinical and laboratory features of children with Kawasaki disease (KD) aged >5 years. METHODS: A retrospective analysis was performed for the clinical data of 250 elderly children (aged >5 years) who were diagnosed with KD or incomplete KD (divided into 5-9 years and >9 years groups) and 266 KD children aged 1-5 years. Clinical and laboratory features were compared between groups. RESULTS: The >9 years group had the lowest incidence rates of hand and foot swelling and fingertip or perianal desquamation (P<0...
November 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30472719/comparison-of-flattening-filter-and-flattening-filter-free-volumetric-modulated-arc-radiotherapy-in-patients-with-locally-advanced-nasopharyngeal-carcinoma
#17
Fei Jia, Dandan Xu, Haizhen Yue, Hao Wu, Guowen Li
BACKGROUND This study aimed to investigate the therapeutic role of flattening filter-free (FFF) mode in volumetric modulated arc therapy (VMAT) compared with flattening filter (FF) mode in patients with locally advanced nasopharyngeal carcinoma (NPC). MATERIAL AND METHODS Ten previously treated patients with NPC underwent treatment re-planning with FFF and FF VMAT. Radiotherapy dose distribution on planning target volume (PTV), organs at risk (OAR), target conformity index (CI), total monitor units (MUs), and therapeutic time were compared...
November 25, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30468476/cd151-promotes-breast-cancer-metastasis-by-activating-tgf-%C3%AE-1-smad-signaling-pathway
#18
S-J Zhao, H-D Zhao, J Li, H Zhang, D-T Gao, Q Wang
OBJECTIVE: This study aimed to explore the expression characteristics of CD151 in breast cancer (BC) and to further study its role in the development of BC and potential regulatory mechanisms. PATIENTS AND METHODS: Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) was used to detect the level of CD151 in 82 pairs of BC tissues and adjacent normal ones, and the relationship between CD151 expression and BC pathological parameters and prognosis was analyzed...
November 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30464613/downregulation-of-foxo6-in-breast-cancer-promotes-epithelial-mesenchymal-transition-and-facilitates-migration-and-proliferation-of-cancer-cells
#19
Hui Ye, Meiling Duan
Purpose: Increasing evidence indicates that members of forkhead transcription factor family (FOXO) play key roles in cell proliferation and apoptosis in multiple cancers, including prostate cancer. However, the underlying mechanism of FOXO6 was not yet known. The aim of our work is to investigate the function of FOXO6 in breast cancer. Methods: In the present study, quantitative real-time polymerase chain reaction and Western blotting analyses were used to detect the expression of FOXO6 in breast cancer tissues and cell lines...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30463064/mirna-1290-promotes-aggressiveness-in-pancreatic-ductal-adenocarcinoma-by-targeting-ikk1
#20
Na Ta, Xiaoyi Huang, Kailian Zheng, Yunshuo Zhang, Yisha Gao, Lulu Deng, Bingbing Zhang, Hui Jiang, Jianming Zheng
BACKGROUND/AIMS: MicroRNAs (miRNAs) are a group of non-coding RNAs that play diverse roles in pancreatic carcinogenesis. In pancreatic ductal adenocarcinoma (PDAC), NF-kB is constitutively activated in most patients and is linked to a mutation in KRAS via IkB kinase complex 1 (IKK1, also known as IKKa). We investigated the link between PDAC aggressiveness and miR-1290. METHODS: We used miRCURYTM LNA Array and in situ hybridization to investigate candidate miRNAs and validated the findings with PCR...
2018: Cellular Physiology and Biochemistry
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