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https://www.readbyqxmd.com/read/30320385/long-non%C3%A2-coding-rna-casc2-inhibits-progression-and-predicts-favorable-prognosis-in-epithelial-ovarian-cancer
#1
Zhuowei Xue, Xiaolu Zhu, Yincheng Teng
Epithelial ovarian cancer (EOC) is one of the leading causes of cancer‑associated mortality in women. At present, the overall 5‑year survival rate of patients with EOC remains poor despite advancements in diagnosis and treatment. Long non‑coding RNAs (lncRNAs) have attracted increasing attention in recent years for their extensive roles in tumorigenesis and cancer development. The lncRNA cancer susceptibility candidate 2 (CASC2) was originally identified as a downregulated gene in endometrial cancer, and subsequent studies revealed that CASC2 was able to act as a tumor suppressor gene in various types of cancer...
October 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30313065/richter-s-syndrome-of-the-central-nervous-system-diagnosed-concurrently-with-chronic-lymphocytic-leukaemia-a-case-report-and-literature-review
#2
Liye Xu, Jin Cheng Song, Xiu Hua Sun, Zi Fen Gao, Li Lv, Jie Zhu
RATIONALE: Central nervous system (CNS) infiltration of Richter's syndrome (RS) is rare and only a few cases were discussed. Of these published cases, either they were accompanied with lymph node involvement or with a history of chronic lymphocytic leukemia (CLL). To our knowledge, this is the first published case of RS of the brain and meninges diagnosed concurrently with CLL in the absence of any evidence of lymphoma outside of the CNS. PATIENT CONCERNS: A 67-year-old female presented with slurred speech, headache, and left-sided hemiparesis...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30312615/does-the-approach-matter-comparing-survival-in-robotic-minimally-invasive-and-open-esophagectomies
#3
Fernando Espinoza-Mercado, Taryne A Imai, Jerald D Borgella, Ariella Sarkissian, Derek Serna-Gallegos, Rodrigo F Alban, Harmik J Soukiasian
BACKGROUND: Our objective is to determine how surgical approach impacts overall survival and postoperative outcomes when comparing robotic-assisted minimally invasive esophagectomy (RAMIE), minimally invasive esophagectomy (MIE) and open esophagectomy (OE). METHODS: The National Cancer Data Base (NCDB) was queried for patients diagnosed with pathologic Stage 0-III esophageal cancer from 2010-2015. Primary outcome measures evaluated were length-of-stay (LOS), 30-day unplanned readmissions, mortality rates at 30 and 90 days, and overall survival rates (OSR)...
October 9, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30298072/prophylactic-treatment-with-simvastatin-modulates-the-immune-response-and-increases-animal-survival-following-lethal-sepsis-infection
#4
Jose A F Braga Filho, Afonso G Abreu, Carlos E P Rios, Liana O Trovão, Dimitri Luz F Silva, Dalila N Cysne, Johnny R Nascimento, Thiare S Fortes, Lucilene A Silva, Rosane N M Guerra, Márcia C G Maciel, Carlos H Serezani, Flávia R F Nascimento
Chronic use of statins may have anti-inflammatory action, promoting immunomodulation and survival in patients with sepsis. This study aimed to analyze the effects of pretreatment with simvastatin in lethal sepsis induced by cecal ligation and puncture (CLP). Male Swiss mice received prophylactic treatment with simvastatin or pyrogen-free water orally in a single daily dose for 30 days. After this period, the CLP was performed. Naïve and Sham groups were performed as non-infected controls. Animal survival was monitored for 60 h after the CLP...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30280774/cd82-kai1-inhibits-invasion-and-metastasis-of-esophageal-squamous-cell-carcinoma-via-tgf-%C3%AE-1
#5
T-D Zeng, B Zheng, W Zheng, C Chen
OBJECTIVE: Previous studies have found that CD82/KAI1 is a tumor suppressor gene. However, the role of CD82/KAI1 in esophageal squamous cell carcinoma (ESCC) has not been reported. This study aims to investigate the specific role of CD82/KAI1 in ESCC, so as to further explore the relationship between CD82/KAI1 expression and clinical characteristics of ESCC. PATIENTS AND METHODS: The expression of CD82/KAI1 in 96 pairs of ESCC tissues and adjacent normal tissues was detected by Real-time quantitative polymerase chain reaction (qRT-PCR)...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30279172/age-related-changes-in-hapln1-increase-lymphatic-permeability-and-affect-routes-of-melanoma-metastasis
#6
Brett L Ecker, Amanpreet Kaur, Stephen M Douglass, Marie R Webster, Filipe V Almeida, Gloria Marino, Andrew J Sinnamon, Madalyn G Neuwirth, Gretchen M Alicea, Abibatou Ndoye, Mitchell Fane, Xiaowei Xu, Myung Shin Sim, Gary B Deutsch, Mark B Faries, Giorgos C Karakousis, Ashani T Weeraratna
Older melanoma patients have lower rates of sentinel lymph node (LN) metastases yet paradoxically have inferior survival. Patient age correlated with an inability to retain Technetium radiotracer during sentinel LN biopsy in over 1000 patients, and high technecium counts correlated to better survival. We hypothesized that loss of integrity in the lymphatic vasculature due to ECM degradation might play a role. We have implicated HAPLN1 in age-dependent ECM degradation in the dermis. Here we queried whether HAPLN1 could be altered in the lymphatic ECM...
October 2, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/30273682/exploring-sialyl-tn-expression-in-microfluidic-isolated-circulating-tumour-cells-a-novel-biomarker-and-an-analytical-tool-for-precision-oncology-applications
#7
Manuel Neves, Rita Azevedo, Luís Lima, Marta I Oliveira, Andreia Peixoto, Dylan Ferreira, Janine Soares, Elisabete Fernandes, Cristiana Gaiteiro, Carlos Palmeira, Sofia Cotton, Stefan Mereiter, Diana Campos, Luís Pedro Afonso, Ricardo Ribeiro, Avelino Fraga, Ana Tavares, Hélder Mansinho, Eurico Monteiro, Paula A Videira, Paulo P Freitas, Celso A Reis, Lúcio Lara Santos, Lorena Dieguez, José Alexandre Ferreira
Circulating tumour cells (CTCs) originating from a primary tumour, lymph nodes and distant metastases hold great potential for liquid biopsies by providing a molecular fingerprint for disease dissemination and its temporal evolution through the course of disease management. CTC enumeration, classically defined on the basis of surface expression of Epithelial Cell Adhesion Molecule (EpCAM) and absence of the pan-leukocyte marker CD45, has been shown to correlate with clinical outcome. However, existing approaches introduce bias into the subsets of captured CTCs, which may exclude biologically and clinically relevant subpopulations...
September 28, 2018: New Biotechnology
https://www.readbyqxmd.com/read/30249872/the-clinical-importance-of-serum-galectin-3-levels-in-breast-cancer-patients-with-and-without-metastasis
#8
Turkan Ozturk Topcu, Halil Kavgaci, Meral Gunaldi, Hakan Kocoglu, Murat Akyol, Ahmet Mentese, Serap Ozer Yaman, Asim Orem, Feyyaz Ozdemir, Fazil Aydin
Objective: Studies have investigated expression status of galectin-3 (Gal-3), but very little is known about the importance of circulating Gal-3 in patients with breast cancer (BC). The purpose of the study was to investigate the clinical significance and potential diagnostic value of plasma Gal-3 levels in patients with BC. Materials and Methods: Fifty-two patients with BC and 35 age-matched healthy controls were enrolled. Levels of Gal-3 were investigated in BC patients and healthy controls...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30247248/the-utility-of-pretreatment-and-posttreatment-lymphopenia-in-cervical-squamous-cell-carcinoma-patients-treated-with-definitive-chemoradiotherapy
#9
Cem Onal, Berna Akkus Yildirim, Ozan Cem Guler, Huseyin Mertsoylu
OBJECTIVE: The aim of this study was to investigate the prognostic significance of pretreatment and posttreatment lymphopenia in locally advanced squamous cell carcinoma (SCC) cervical cancer patients treated with definitive chemoradiotherapy (ChRT). METHODS: Data from 95 patients with SCC were retrospectively analyzed. Relationships between pretreatment or posttreatment lymphopenia and patient or tumor characteristics, and overall survival (OS) and disease-free survival (DFS) were evaluated...
October 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/30246651/the-utility-of-rdw-in-discrimination-of-sarcoidosis-and-tuberculous-lymphadenitis-diagnosed-by-ebus
#10
Mevlüt Karataş, Ayperi Öztürk
Introduction: Erythrocyte distribution width (RDW) is an important indicator of anisocytosis, which is used in the differential diagnosis of anemia and is easily accessible in the complete blood count results. Increased RDW values in coronary artery diseases, pulmonary hypertension and malignancies were detected in the studies. We aimed to demonstrate the usefulness of blood RDW level for the differential diagnosis of granulomatous lymphadenitis associated with tuberculosis and sarcoidosis in our study...
June 2018: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/30232539/-225-ac-psma-617-in-chemotherapy-naive-patients-with-advanced-prostate-cancer-a-pilot-study
#11
Mike Sathekge, Frank Bruchertseifer, Otto Knoesen, Florette Reyneke, Ismaheel Lawal, Thabo Lengana, Cindy Davis, Johncy Mahapane, Ceceila Corbett, Mariza Vorster, Alfred Morgenstern
BACKGROUND: A remarkable therapeutic efficacy has been demonstrated with 225 Ac-prostate-specific membrane antigen (PSMA)-617 in heavily pre-treated metastatic castration-resistant prostate cancer (mCRPC) patients. We report our experience with 225 Ac-PSMA-617 therapy in chemotherapy-naïve patients with advanced metastatic prostate carcinoma. METHODS: Seventeen patients with advanced prostate cancer were selected for treatment with 225 Ac-PSMA-617 in 2-month intervals, with initial activity of 8 MBq, then de-escalation to 7 MBq, 6 MBq or 4 MBq in cases of good response...
September 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30231242/oxysophocarpine-retards-the-growth-and-metastasis-of-oral-squamous-cell-carcinoma-by-targeting-the-nrf2-ho-1-axis
#12
Rui Liu, Jia Peng, Huili Wang, Lei Li, Xiujie Wen, Yan Tan, Lin Zhang, Haoyuan Wan, Faming Chen, Xie Nie
BACKGROUND/AIMS: Nuclear factor erythroid 2-related factor 2 (Nrf2) is an oncogene in various types of cancers, including oral squamous cell carcinoma (OSCC). Oxysophocarpine (OSC) is a natural alkaloid that has multiple pharmacological activities. However, the biological functions and molecular mechanism underlying the effects of OSC on the growth and metastasis of OSCC are unclear. METHODS: Nrf2 levels were determined in OSCC tissues and non-cancerous specimens by quantitative real-time PCR, western blotting, and immunohistochemistry (IHC) assays...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30229963/a-case-of-canine-high-grade-t-cell-lymphoma-immunophenotypically-consistent-with-t-zone-lymphoma
#13
Cyril Parachini-Winter, Kaitlin M Curran, Duncan S Russell, Elena Gorman
A 9-year-old spayed female Curly Coated Retriever was referred for evaluation of generalized peripheral lymphadenomegaly. The dog was clinically healthy on presentation with no anomalies detected on complete blood count, serum biochemistry, urinalysis, or three-view thoracic radiographs. Fine-needle aspiration (FNA) and cytology of the peripheral lymph nodes were consistent with lymphoma with an intermediate-sized lymphoid population. Flow cytometry of peripheral lymph nodes was consistent with a homogeneous population of CD4+ T cells that had lost expression of the pan-leukocyte antigen CD45...
September 19, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30229818/upk1b-promotes-the-invasion-and-metastasis-of-bladder-cancer-via-regulating-the-wnt-%C3%AE-catenin-pathway
#14
F-H Wang, X-J Ma, D Xu, J Luo
OBJECTIVE: The aim of this study was to investigate the expression of UPK1B in bladder cancer (BCa), and to further explore the correlation between UPK1B expression and pathological parameters as well as the prognosis of BCa. PATIENTS AND METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of UPK1B in 92 pairs of BCa tissues and adjacent normal tissues. The relationship between UPK1B expression and pathological features as well as the prognosis of BCa patients was further analyzed...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30225835/clinical-implications-of-extensive-lymph-node-metastases-for-resected-pancreatic-cancer
#15
Cinthya Y Lowder, James Metkus, Jeffrey Epstein, Geoffrey M Kozak, Harish Lavu, Charles J Yeo, Jordan M Winter
BACKGROUND: Outcomes of patients with resected pancreatic ductal adenocarcinoma (PDA) and extensive lymph node metastases have not been fully characterized. METHODS: A total of 637 patients underwent resection for pancreatic ductal adenocarcinoma (PDA) between 2002 and 2014 at the Thomas Jefferson University. Positive lymph node count (LNC) and positive lymph node ratio (LNR) were analyzed as predictors of cancer-specific outcomes, with a focus on outcomes of patients with extensive lymph node burden...
September 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30214590/downregulation-of-peroxiredoxin-ii-suppresses-the-proliferation-and-metastasis-of-gastric-cancer-cells
#16
Linjun Niu, Ang Liu, Wei Xu, Liang Yang, Wugang Zhu, Yuming Gu
Peroxiredoxin (Prx) II is an imperative member of the superfamily of peroxidases. It serves an essential role in scavenging organic hydroperoxide and H2 O2 . It is involved in the development of various malignant tumors. In order to investigate the significance of Prx II expressions level in gastric cancer (GC), downregulation of Prx II was performed to investigate its role in the proliferation and migration of gastric adenocarcinoma cells. In GC cells and 45 GC specimens, the mRNA and protein expression levels of Prx II were determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis, respectively...
October 2018: Oncology Letters
https://www.readbyqxmd.com/read/30196579/the-effect-of-preoperative-treatments-on-lymph-node-counts-after-total-gastrectomy-in-esophagogastric-adenocarcinoma
#17
Ziyu Li, Shuangxi Li, Zhaode Bu, Lianhai Zhang, Xiaojiang Wu, Fei Shan, Yongning Jia, Xin Ji, Jiafu Ji
OBJECTIVES: This study aims to explore the effects of preoperative treatments on lymph nodes (LNs) counts after total gastrectomy with D2 lymphadenectomy in esophagogastric adenocarcinoma. METHODS: A retrospective analysis was performed for 446 patients with locally advanced esophagogastric adenocarcinoma. The patients were divided into three groups: surgery first (SF), preoperative chemotherapy (PCT), and preoperative chemoradiotherapy (PCRT). Clinical-pathological data were analyzed...
September 9, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30194187/impact-of-lymph-node-yield-on-outcome-of-patients-with-head-and-neck-cancer-and-pn0-neck
#18
COMPARATIVE STUDY
Saskia Merz, Nina Timmesfeld, Boris A Stuck, Susanne Wiegand
BACKGROUND/AIM: The extent of neck dissection in patients with head and neck cancer (HNSCC) and N0 neck remains controversial. The aim of this study was to evaluate the influence of lymph node yield on overall survival in patients with pathologically node-negative HNSCC. PATIENTS AND METHODS: A retrospective analysis was performed on 157 pN0 HNSCC patients undergoing primary surgery with neck dissection between 2000 and 2014. The patients were divided into three groups according to the lymph node count using the optimal cut-points method...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30187336/prognostic-implication-of-negative-lymph-node-count-in-ypn-rectal-cancer-after-neoadjuvant-chemoradiotherapy-and-construction-of-a-prediction-nomogram
#19
Yanwu Sun, Yiyi Zhang, Zhekun Huang, Pan Chi
PURPOSE: This study aimed to investigate the prognostic significance of negative lymph nodes (NLNs) for ypN+ rectal cancer after neoadjuvant chemoradiotherapy (nCRT) and radical surgery and to construct a nomogram predicting disease-free survival (DFS). METHOD: One hundred fifty-eight eligible patients were included. X-tile analysis was performed to determine cutoff values of NLNs. Clinicopathological and survival outcomes were compared. A Cox regression analysis was performed to identify prognostic factors of DFS...
September 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/30186440/hemophagocytic-lymphohistiocytosis-presenting-with-annular-erythema-multiforme-like-eruptions-in-a-patient-with-angioimmunoblastic-t-cell-lymphoma-a-case-report
#20
Liping Zhang, Chunguang Tong, Yaqi Tan, Shiguang Peng, Yanling He, Tianyou Wang
Angioimmunoblastic T cell lymphoma (AITL)-associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme-like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme-like eruptions. However, antihistamine treatment was ineffective. The patient progressed rapidly with high fever, hepatosplenomegaly and pharyngitis. The number of copies of Epstein-Barr virus DNA continuously increased...
September 2018: Experimental and Therapeutic Medicine
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