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https://www.readbyqxmd.com/read/29658968/comet-and-cytogenetic-tests-as-tools-for-evaluating-genomic-instability-in-seeds-of-oryza-sativa-l-and-phaseolus-vulgaris-l-from-gene-banks
#1
Alisson F Dantas, Renata M Lopes, Maria L Fascineli, Solange C B R José, Juliano G Pádua, Marcos A Gimenes, Cesar K Grisolia
This study aimed to assess the feasibility of comet and cytogenetic tests as tools for evaluating genomic instability in seeds of Oryza sativa L. (rice) and Phaseolus vulgaris (beans) L. from gene banks. Rice and beans were exposed to methyl methanesulfonate (MMS) as a reference DNA damaging agent. Seeds of two accessions of rice and beans were obtained from Embrapa Rice and Beans - Brazil. Seed groups were imbibed in three concentrations of MMS for three periods of time to carry out cytogenetic tests, and for one period for the comet test...
January 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29644406/the-wessex-modified-richmond-sedation-scale-as-a-novel-tool-for-monitoring-patients-at-risk-of-malignant-mca-syndrome
#2
Tayyib T A Hayat, Matthew A Myers, John Hell, Matthew Cordingly, Diederik O Bulters, Nicolas Weir, George Pengas
BACKGROUND: The Wessex Modified Richmond Sedation Scale (WMRSS) has been developed with the aim of improving the early identification of patients requiring decompressive hemicraniectomy for malignant middle cerebral artery syndrome (MMS). The objective of this study was to evaluate the WMRSS against the Glasgow Coma Scale (GCS). METHODS: A retrospective study was conducted of patients admitted to our unit for observation of MMS. Data were obtained on WMRSS and GCS recordings from admission up to 120-h post-ictus...
April 11, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29623411/timing-of-rehabilitation-in-children-with-obstetric-upper-trunk-brachial-plexus-palsy
#3
Volkan Yilmaz, Ebru Umay, Nihal Tezel, Ibrahim Gundogdu
OBJECTIVES: The initiation timing of rehabilitation in children with obstetric brachial plexus palsy is controversial. The aim of the present study is to evaluate the effectiveness of rehabilitation timing to the functional outcomes of patients with obstetric upper trunk brachial plexus palsy. MATERIAL AND METHODS: Twenty-nine patients, who did not previously received any rehabilitation programme but attended our outpatient clinic, were included for the study. The electrophysiological findings, obstetric characteristics, and demographic features of the patients were recorded...
April 5, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29608116/modified-mixed-nanomicelles-with-collagen-peptides-enhanced-oral-absorption-of-cucurbitacin-b-preparation-and-evaluation
#4
Lan Tang, Lulu Fu, Zhuanfeng Zhu, Yan Yang, Boxuan Sun, Weiguang Shan, Zhenhai Zhang
Polymer nanoparticles modified with collagen peptides (CPs) are an attractive strategy for the oral delivery of active ingredients from Chinese medicine. Thus, in the present study, collagen cationic CPs were simply separated using ion-exchange resin from bovine CPs, to modify mixed nanomicelles (MMs) on the surface to improve the oral bioavailability of Cucurbitacin B (CuB). The physicochemical property of micelles was characterized, which confirmed the successful modification of the nanomicelles. CPs-modified nanomicelles in vitro were found to significantly increase cellular uptake and transportation...
January 1, 2018: Drug Delivery
https://www.readbyqxmd.com/read/29605568/-mixed-methods-studies-in-the-health-sciences-a-critical-map
#5
Marlen Niederberger, Lisa Peter
Mixed methods studies (MMS) play an increasingly important role in the health sciences. Its potential lies in the acquisition of causal conditions and in the intersubjective understanding of diverse and new phenomena. The holistic and multi-perspective analysis strategy of MMS also allows a subject-oriented and an evidence-based approach to clinical practice. The article reviews the use of MMS in the health sciences on the basis of various reviews, and it highlights current methodological developments and research gaps...
March 28, 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29601150/comparing-the-efficacy-of-silastic-and-gloved-merocel-middle-meatal-spacers-for-functional-endoscopic-sinus-surgery-a-randomized-controlled-trial
#6
Jamil Manji, Al-Rahim R Habib, Luis Macias-Valle, Andres Finkelstein, Saad Alsaleh, Anali Dadgostar, Fahad Al-Asousi, Christopher Okpaleke, Amin R Javer
BACKGROUND: Spacers are inserted into the middle meatal space (MMS) following functional endoscopic sinus surgery (FESS) to prevent lateralization of the middle turbinate, scarring, and synechiae. Our objective was to determine if the incidence of postoperative synechiae, facial pain/discomfort, pain during spacer removal, scarring, and discharge differed between nasal cavities receiving Silastic or gloved-Merocel (GM) spacers following FESS. METHODS: A double-blind, randomized controlled trial (RCT) was conducted in adults requiring bilateral FESS for chronic rhinosinusitis (CRS) ± nasal polyposis...
March 30, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29587439/nf2-merlin-inactivation-and-potential-therapeutic-targets-in-mesothelioma
#7
REVIEW
Tatsuhiro Sato, Yoshitaka Sekido
The neurofibromatosis type 2 ( NF2 ) gene encodes merlin, a tumor suppressor protein frequently inactivated in schwannoma, meningioma, and malignant mesothelioma (MM). The sequence of merlin is similar to that of ezrin/radixin/moesin (ERM) proteins which crosslink actin with the plasma membrane, suggesting that merlin plays a role in transducing extracellular signals to the actin cytoskeleton. Merlin adopts a distinct closed conformation defined by specific intramolecular interactions and regulates diverse cellular events such as transcription, translation, ubiquitination, and miRNA biosynthesis, many of which are mediated through Hippo and mTOR signaling, which are known to be closely involved in cancer development...
March 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29582593/-preparation-of-hydrophilic-polymer-brushes-magnetic-microspheres-by-surface-initiated-for-magnetic-dispersive-solid-phase-extraction-of-tetracycline-antibiotic-residues-from-honey
#8
Shaodan Zhou, Jiaqi Tang, Bo Jia, Yunkai Lü
Activators regenerated by electron transfer-atom transfer radical polymerization (ARGET-ATRP) was applied to the continuous grafting of polybasic polymers and poly(ethylene glycol) (PEG) brushes on the surface of the magnetic microspheres (MMs). At first, the MMs were coated with silica gel, modified by amino group, and then 2-bromoisobutyryl bromide was grafted on the surface of MMs. After that, the hydrophilic polymer brushes magnetic microspheres (HMMs) were prepared by polymerization on the surface of the MMs...
February 8, 2018: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29580937/the-windmill-task-as-a-new-quantitative-and-objective-assessment-for-mirror-movements-in-unilateral-cerebral-palsy-a-pilot-study
#9
Ingar Marie Zielinski, Bert Steenbergen, Anna Schmidt, Katrijn Klingels, Cristina Simon Martinez, Pascal de Water, Brian Hoare
OBJECTIVE: To introduce the Windmill-task, a new objective assessment to quantify the presence of mirror movements (MMs) in children with unilateral cerebral palsy (uCP). In children with uCP MMs are frequently observed. They are typically assessed with the observation-based Woods and Teuber scale (W&T). However, due to its subjective nature and variable administration, interpretation of data across studies is problematic. DESIGN: Prospective, observational, cohort pilot study...
March 23, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29575263/mohs-micrographic-surgery-for-cutaneous-malignancies-a-focus-review-of-its-indications-in-pediatric-age-groups
#10
REVIEW
Stephanie T Le, Heba Y Kamal, Amor Khachemoune
Mohs micrographic surgery (MMS) is a highly specialized technique that has been successful in the treatment of a variety of skin tumors. The technique can be performed as an outpatient procedure and encompasses surgical excision and intraoperative assessment of tumor margins in one setting by the same physician. The process ensures precise margin control with maximal preservation of healthy tissues. Mohs micrographic surgery has been practiced worldwide, including in the United States, Europe (United Kingdom, Germany, Spain, Netherlands, Switzerland), and Australia...
March 25, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29573292/in-vivo-reflectance-confocal-microscopy-combined-with-the-spaghetti-technique-for-the-identification-of-surgical-margins-of-lentigo-maligna-experience-in-70-patients
#11
Emmanuelle Couty, Linda Tognetti, Bruno Labeille, Catherine Douchet, Cyril Habougit, Caroline Couzan, Anne Catherine Biron-Schneider, Frédéric Cambazard, Virginie Prade, Pietro Rubegni, Elisa Cinotti, J L Perrot
Lentigo maligna (LM) and lentigo maligna melanoma (LMM) account for 10% of all melanomas and are mainly located on head and neck areas.1-4 Complete surgical excision is the recommended treatment. However, this treatment is often challenging because of LM/LMM location in the face and the difficulty in the identification of its surgical margins1-5 . Local recurrence of LM/LMM still represents a major concern with recurrence rates after conventional surgical excision of 8 to 20% of cases, up to 47% in absence of Mohs micrographic surgery (MMS)...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29567577/development-of-atherosclerotic-moyamoya-syndrome-with-genetic-variant-of-rnf213-p-r4810k-and-p-t1727m-a-case-report
#12
Ying Liu, Xueying Wu, Zhaoyang Fan, Jingdan Cheng, Lele Zhong, Yongzhong Lin, Xiaofeng Qu
OBJECTIVE: We report a rare case of atherosclerotic-moyamoya syndrome (A-MMS) in an adult female with genetic variant of both ring finger 213 (RNF213) p.R4810K and p.T1727M. CASE REPORT: A 46-year-old previously healthy, right-handed woman displayed transient slurred speech, which started to worsen four years ago. Initial magnetic resonance angiography (MRA) revealed stenosis in left middle cerebral artery (MCA), bilateral anterior cerebral artery (ACA), and left posterior cerebral artery (PCA)...
February 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29565815/targeting-the-hippo-pathway-is-a-new-potential-therapeutic-modality-for-malignant-mesothelioma
#13
REVIEW
Yoshitaka Sekido
Malignant mesothelioma (MM) constitutes a very aggressive tumor that arises from the pleural or peritoneal cavities and is highly refractory to conventional therapies. Several key genetic alterations are associated with the development and progression of MM including mutations of the CDKN2A/ARF , NF2 , and BAP1 tumor-suppressor genes. Notably, activating oncogene mutations are very rare; thus, it is difficult to develop effective inhibitors to treat MM. The NF2 gene encodes merlin, a protein that regulates multiple cell-signaling cascades including the Hippo pathway...
March 22, 2018: Cancers
https://www.readbyqxmd.com/read/29561746/melanoma-of-the-face-and-mohs-micrographic-surgery-nationwide-mortality-data-analysis
#14
Oleksandr Trofymenko, Jeremy S Bordeaux, Nathalie C Zeitouni
BACKGROUND: Although Mohs micrographic surgery (MMS), narrow margin excision (NME), and wide margin excision (WME) are commonly used to treat melanoma of the face, there is a paucity of data comparing mortality outcomes for each method. OBJECTIVE: To determine the association between surgical method used to treat cutaneous melanoma of the face and patient survival. MATERIALS AND METHODS: A retrospective review of Surveillance, Epidemiology, and End Results registries for patients diagnosed with melanoma of the face between 2003 and 2012 was conducted...
December 8, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29560385/c-fos-mapping-of-brain-regions-activated-by-multi-modal-and-electric-foot-shock-stress
#15
Xiaoxiao Lin, Christy A Itoga, Sharif Taha, Ming H Li, Ryan Chen, Kirolos Sami, Fulvia Berton, Walter Francesconi, Xiangmin Xu
Real-world stressors are complex and multimodal, involving physical, psychological, and social dimensions. However, the brain networks that mediate stress responses to these stimuli need to be further studied. We used c-Fos mapping in mice to characterize brain circuits activated by exposure to a single episode of multimodal stress (MMS), and compared these to circuits activated by electric foot shocks (EFS). We focused on characterizing c-Fos activity in stress-relevant brain regions including the paraventricular nucleus (PVN) of the hypothalamus and the bed nucleus of the stria terminalis (BNST)...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29554631/the-characterization-of-%C3%AE-h2ax-and-p53-as-biomarkers-of-genotoxic-stress-in-a-rainbow-trout-oncorhynchus-mykiss-brain-cell-line
#16
Mark E Hamilton, Niels C Bols, Bernard P Duncker
Rainbow trout cell cultures were exposed to three genotoxicants and examined for effects on γH2AX and p53 levels by western blotting and on cell viability using the indicator dyes Alamar Blue (AB) for energy metabolism and 5'-carboxyfluorescein diacetate acetoxymethyl ester (CFDA-AM) for plasma membrane integrity. Bleomycin induced γH2AX and p53 in a dose- and time-dependent manner and had little cytotoxic effect. However, induction was first seen at 0.3 μM for γH2AX but not until 16.5 μM for p53. Methyl methanesulfonate (MMS) increased H2AX phosphorylation but diminished p53 levels as the dose was increased from 908 μM up to 2724 μM...
March 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29541160/parental-origin-of-deletions-and-duplications-about-the-necessity-to-check-for-cryptic-inversions
#17
Thomas Liehr, Isolde Schreyer, Alma Kuechler, Emmanouil Manolakos, Sylke Singer, Andreas Dufke, Kathleen Wilhelm, Tereza Jančušková, Radek Čmejla, Moneeb A K Othman, Ahmed H Al-Rikabi, Kristin Mrasek, Monika Ziegler, Stefanie Kankel, Katharina Kreskowski, Anja Weise
Background: Copy number variants (CNVs) are the genetic bases for microdeletion/ microduplication syndromes (MMSs). Couples with an affected child and desire to have further children are routinely tested for a potential parental origin of a specific CNV either by molecular karyotyping or by two color fluorescence in situ hybridization (FISH), yet. In the latter case a critical region probe (CRP) is combined with a control probe for identification of the chromosome in question. However, CNVs can arise also due to other reasons, like a recombination-event based on a submicroscopic, cryptic inversion in one of the parents...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29531123/tight-regulation-of-srs2-helicase-activity-is-crucial-for-proper-functioning-of-dna-repair-mechanisms
#18
Alex Bronstein, Shay Bramson, Keren Shemesh, Batia Liefshitz, Martin Kupiec
Proper DNA damage repair is one of the most vital and fundamental functions of every cell. Several different repair mechanisms exist to deal with various types of DNA damage, in various stages of the cell cycle and under different conditions. Homologous recombination is one of the most important repair mechanisms in all organisms. Srs2, a regulator of homologous recombination, is a DNA helicase involved in DNA repair, cell cycle progression and genome integrity. Srs2 can remove Rad51 from ssDNA, and is thought to inhibit unscheduled recombination...
March 12, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29528766/assessment-of-genotoxicity-and-genomic-instability-in-rat-primary-astrocytes-exposed-to-872-mhz-radiofrequency-radiation-and-chemicals
#19
Mikko Herrala, Ehab Mustafa, Jonne Naarala, Jukka Juutilainen
PURPOSE: We examined genotoxicity, co-genotoxicity and induced genomic instability (IGI) in primary astrocytes exposed to radiofrequency (RF) radiation. MATERIALS AND METHODS: Rat primary astrocytes were exposed to 872 MHz GSM-modulated or continuous wave (CW) RF radiation at specific absorption rates of 0.6 or 6.0 W/kg for 24 h. Menadione (MQ) and methyl methanesulfonate (MMS; only in genotoxicity experiments) were used as co-exposures. Alkaline Comet assay and flow cytometric micronucleus scoring were used to detect genetic damage...
March 12, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29520940/water-does-not-always-hurt-synthesis-of-an-iron-iv-aqua-oxido-complex-using-ozone-as-an-oxidant
#20
Stefan Schaub, Andreas Miska, Jonathan Becker, Stefan Zahn, Doreen Mollenhauer, Sakshath Sadashivaiah, Volker Schünemann, Siegfried Schindler
The iron(IV) oxido complex [(tmc)Fe=O(OTf)]OTf with the macrocyclic ligand 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclo-tetradecane (tmc) has been synthesized using ozone as an oxidant. By adding water to this compound the complex [(H2O)(tmc)Fe=O)](OTf)2 could be prepared. This complex is important in regard to a better understanding of the reactivity of Fe(IV) oxido complexes. Mössbauer measurements using the solid compound showed an isomer shift of = 0.19 mms-1 and a quadrupole splitting EQ = 1.38 mms-1 confirming the high valent Fe(IV) state...
March 9, 2018: Angewandte Chemie
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