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https://www.readbyqxmd.com/read/28107578/patient-satisfaction-and-the-waiting-room-in-mohs-surgery-appropriate-pre-warning-may-abrogate-boredom
#1
F R Ali, F Al-Niaimi, E E Craythorne, R Patalay, R Mallipeddi
Patient satisfaction in dermatology consultations has rightly been afforded attention by De Salins and colleagues.(1) When considering the patient journey through an outpatient appointment, a significant proportion of time is spent in the waiting room, a period which is poorly understood and may contribute to patient anxiety and perceived satisfaction with treatment.(2) In our outpatient Mohs micrographic surgery (MMS) unit, patients may be waiting for several hours in total whilst histological specimens are processed and analysed, prior to reconstruction, particularly if multiple MMS stages are needed...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28104119/association-of-the-number-of-hla-dr-mismatches-with-early-post-transplant-acute-cellular-rejection-among-heart-transplantation-recipients-a-cohort-study-in-japanese-population
#2
D Nitta, K Kinugawa, T Imamura, J Iino, M Endo, E Amiya, M Hatano, O Kinoshita, K Nawata, M Ono, I Komuro
BACKGROUND: Although many risk factors are reported about graft rejection after heart transplantation (HTx), the effect of HLA mismatch (MM) still remains unknown, especially in the Japanese population. The aim of the present study was to investigate the influence of HLA MM on graft rejection among HTx recipients in Japan. METHODS: We retrospectively investigated the association of the number of HLA MM including class I (A, B) and class II (DR) (for each locus MM: 0 to 2, total MM: 0 to 6) and the incidence of moderate to severe acute cellular rejection (ACR) confirmed by endomyocardial biopsy (International Society for Heart and Lung Transplantation grade ≥ 3A/2R) within 1 year after HTx...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28095787/the-effects-of-habitual-functional-training-on-physical-functioning-in-patients-after-hip-fracture-the-protocol-of-the-hipfrac-study
#3
Kristi Elisabeth Heiberg, Vigdis Bruun-Olsen, Astrid Bergland
BACKGROUND: The survivors after hip fracture often report severe pain and loss of physical functioning. The poor outcomes cause negative impact on the person's physical functioning and quality of life and put a financial burden on society. Rehabilitation is important to improve physical functioning after hip fracture. To maintain the continuity in rehabilitation we have an assumption that it is of utmost importance to continue and progress the functional training that already started at the hospital, while the patients are transferred to short-term stays in a nursing home before they are returning to home...
January 17, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28095571/effectiveness-of-the-mohs-and-close-technique-in-increasing-the-efficiency-of-a-mohs-micrographic-surgery
#4
Dhwani Mehta, Rebecca Jacobsen, Tonja Godsey, Brian Adams, Hugh Gloster
INTRODUCTION: Mohs micrographic surgery (MMS) is successful and cost effective, but may be time consuming as patients are required to wait for final wound repair until margins are clear. We propose for selected cases the "Mohs and Close technique" (MCT), in which the defect is immediately repaired after tumor resection rather than waiting until margins are clear. METHODS: MCT was only performed on tumors that had clearly de ned borders, low risk histology, whose resulting defect after exci- sion required either a primary or partial closure, and whose repair wouldn't change to a different repair option if further stages of exci- sion were necessary...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28089177/cell-cycle-dependent-positive-and-negative-functions-of-fun30-chromatin-remodeler-in-dna-damage-response
#5
Jasmine Siler, Bowen Xia, Carina Wong, Morgan Kath, Xin Bi
The evolutionally conserved Fun30 chromatin remodeler in Saccharomyces cerevisiae has been shown to contribute to cellular resistance to genotoxic stress inflicted by camptothecin (CPT), methyl methanesulfonate (MMS) and hydroxyurea (HU). Fun30 aids in extensive DNA resection of DNA double stranded break (DSB) ends, which is thought to underlie its role in CPT-resistance. How Fun30 promotes MMS- or HU-resistance has not been resolved. Interestingly, we have recently found Fun30 to also play a negative role in cellular tolerance to MMS and HU in the absence of the Rad5-dependent DNA damage tolerance pathway...
January 5, 2017: DNA Repair
https://www.readbyqxmd.com/read/28088491/toxicogenetic-study-of-persea-americana-fruit-pulp-oil-and-its-effect-on-genomic-instability
#6
Heloiza Diniz Nicolella, Francisco Rinaldi Neto, Mariana Beltrame Corrêa, Danillo Henrique Lopes, Edilaura Nunes Rondon, Luiz Felipe Ribeiro Dos Santos, Pollyanna Francielli de Oliveira, Jaqueline Lopes Damasceno, Nathália Oliveira Acésio, Izabel Cristina Casanova Turatti, Marcos Gomide Tozatti, Wilson Roberto Cunha, Ricardo Andrade Furtado, Denise Crispim Tavares
Persea americana Mill., commonly known as avocado, is a tree native to Central America that is widely used as a food source and for the treatment of diseases. This plant has various biological properties such as analgesic, anti-inflammatory and total cholesterol-lowering activity. In view of its pharmacological potential, we conducted a toxicogenetic study of the fruit pulp oil of P. americana (PAO) and investigated its influence on genotoxicity induced by methyl methanesulfonate (MMS) and doxorubicin. V79 cells and Swiss mice were used for the assays...
January 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28087532/establishment-and-validation-of-rna-based-predictive-models-for-understanding-survival-of-vibrio-parahaemolyticus-in-oysters-stored-at-low-temperatures
#7
Chao Liao, Yong Zhao, Luxin Wang
: This study developed RNA-based predictive models describing the survival of Vibrio parahaemolyticus in Eastern oysters (Crassostrea virginica) during storage at 0, 4, and 10°C. Post-harvested oysters were inoculated with a cocktail of five V. parahaemolyticus strains and were then stored at 0, 4, and 10°C for 21 or 11 days. A real-time RT-PCR assay targeting expression of tlh gene was used to evaluate the number of surviving V. parahaemolyticus, which was then used to establish primary molecular models (MMs)...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28079637/ln2-cd10-and-ezrin-do-not-distinguish-between-atypical-fibroxanthoma-and-undifferentiated-pleomorphic-sarcoma-or-predict-clinical-outcome
#8
Allison Hanlon, Thomas Stasko, Dan Christiansen, Nika Cyrus, Anjela Galan
BACKGROUND: Atypical fibroxanthoma (AFX) is a rare cutaneous spindled cell neoplasm. For both diagnostic and therapeutic purposes, it is important to distinguish AFX from other poorly differentiated tumors, including undifferentiated pleomorphic sarcoma (UPS). OBJECTIVE: The authors aimed to identify the clinical, histologic, and immunohistochemical expression of LN2, ezrin, and CD10 in AFX and UPS tumors. METHODS AND MATERIALS: The authors retrospectively examined the charts of patients with AFX and UPS treated with Mohs micrographic surgery (MMS) at 2 academic institutions...
January 10, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28061446/%C3%AE-40p53-is-involved-in-the-inactivation-of-autophagy-and-contributes-to-inhibition-of-cell-death-in-hct116-%C3%AE-40p53-cells
#9
Yunjin Zang, Ying Shi, Kai Liu, Luxin Qiao, Xianghua Guo, Dexi Chen
Δ40p53 is an isoform of wild-type p53 (wtp53). Here, we assessed whether Δ40p53 has the same functions as wild-type p53 in the regulation of cell death and autophagy. First, we used HCT116 (p53+/+) and H1299 (p53-free) cells to produce two cell lines (HCT116-Δ40p53 and H1299-Δ40p53) that express exogenous Δ40p53 but not wtp53. By using these cell lines, we determined that Δ40p53 inhibited starvation-induced autophagy, as does wtp53. This inhibition arises from both Δ40p53 and wtp53 having 3'-5' exonuclease activity, which reduces the levels of double-stranded RNA (dsRNA) and then inhibits PKR/eIF2α-induced autophagy in cells exposed to starvation...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28060173/squamous-cell-carcinoma-in-situ-upstaged-to-invasive-squamous-cell-carcinoma-a-5-year-single-institution-retrospective-review
#10
Sasima Eimpunth, Alina Goldenberg, Michael Shane Hamman, Gagik Oganesyan, Robert A Lee, Saowalak Hunnangkul, Silvia Soohyun Song, Tanya Greywal, Shang I Brian Jiang
BACKGROUND: Shave biopsy may not be able to accurately distinguish squamous cell carcinoma in situ (SCCIS) from invasive squamous cell carcinoma (SCC). Information on the incidence of biopsy-proven SCCIS upstaged to SCC after a more complete histologic examination is limited. OBJECTIVE: To determine the incidence and clinical risk factors associated with upstaging the biopsy diagnosis of SCCIS into invasive SCC based on findings during Mohs micrographic surgery (MMS)...
December 29, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28051835/mesothelioma-and-interferon-%C3%AE-dependent-chemokine-ip-10
#11
P Fallahi, F Ragusa
Recently it has been shown that interferon (IFN)-γ plays an important role in mesothelioma, mediated by the main IFN-γ dependent chemokines, chemokine (C-X-C motif) ligand (CXCL)10/IFN-γ- induced protein 10 (IP-10). IP-10 is up-regulated in malignant mesothelioma (MM), suggesting a relationship with development of these tumors. Nanoparticles containing nickel, that increase the risk for pleural diseases, induced increased levels of IP-10 in rat pleural mesothelial cells. Chemokine (C-X-C motif) receptor (CXCR)3 expression in CD4(+) T cells from pleural plaques and MMs was significantly decreased compared with that from healthy donors suggesting that CXCR3, IFN-γ, and IP-10 may be candidates to detect and monitor disease status...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28042855/line-based-registration-of-panoramic-images-and-lidar-point-clouds-for-mobile-mapping
#12
Tingting Cui, Shunping Ji, Jie Shan, Jianya Gong, Kejian Liu
For multi-sensor integrated systems, such as the mobile mapping system (MMS), data fusion at sensor-level, i.e., the 2D-3D registration between an optical camera and LiDAR, is a prerequisite for higher level fusion and further applications. This paper proposes a line-based registration method for panoramic images and a LiDAR point cloud collected by a MMS. We first introduce the system configuration and specification, including the coordinate systems of the MMS, the 3D LiDAR scanners, and the two panoramic camera models...
December 31, 2016: Sensors
https://www.readbyqxmd.com/read/28040914/note-improving-distributed-strain-sensing-sensitivity-in-ofdr-by-reduced-cladding-single-mode-fiber
#13
Zhenyang Ding, Di Yang, Yang Du, Yonghan Zhou, Zhexi Xu, Kun Liu, Junfeng Jiang, Tiegen Liu
We present a method to improve distributed strain sensing sensitivity by a reduced-cladding single mode fiber (RC SMF) using a Rayleigh backscattering spectra shift in optical frequency domain reflectometry. Comparing with a standard SMF with 250 μm diameter, a commercial low attenuation RC SMF with 165 μm diameter is shown to enhance the strain sensing sensitivity by about four-fold. Using this property, the system using the RC SMF can achieve smaller minimal measurable strain (MMS) in the same sensing spatial resolution (SSR) or smaller SSR in the same MMS than using the standard SMF...
December 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28025680/impact-of-surgery-on-quality-of-life-of-women-with-obstetrical-fistula-a-qualitative-study-in-burkina-faso
#14
Julie Désalliers, Marie-Eve Paré, Salam Kouraogo, Jacques Corcos
INTRODUCTION AND HYPOTHESIS: Obstetric fistula, caused by traumatic delivery and patient lack of access to obstetric care, is an important public health concern in developing countries, particularly in Sub-Saharan Africa. This research focuses on the experience of women living with obstetric fistula in Burkina Faso as well as their reintegration into community after surgery. METHODS: This project was funded by the Mères du Monde en Santé (MMS) Foundation and conducted in collaboration with the Boromo Hospital...
December 26, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/28018592/dna-damage-and-repair-capacity-in-lymphocyte-of-chronic-obstructive-pulmonary-diseases-patients-during-physical-exercise-with-oxygen-supplementation
#15
Andréa Lúcia Gonçalves da Silva, Thaís Evelyn Karnopp, Augusto Ferreira Weber, Cassia da Luz Goulart, Paloma de Borba Scheneiders, Dannuey Machado Cardoso, Lisiane Lisboa Carvalho, Joel Henrique Ellwanger, Lia Gonçalves Possuelo, Andréia Rosane de Moura Valim
BACKGROUND: We hypothesized that the use of oxygen supplementation during aerobic exercise induces less DNA damage than exercise alone. The aim of this study is to assess the level of DNA damage induced by physical exercise with and without oxygen supplementation in chronic obstructive pulmonary diseases (COPD) patients. METHODS: Peripheral blood was collected before and after aerobic exercise in two conditions: (I) aerobic exercise without oxygen supplementation (AE group) and (II) with oxygen supplementation (AE-O2 group)...
2016: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28018351/allorecognition-of-hla-c-mismatches-by-cd8-t-cells-in-hematopoietic-stem-cell-transplantation-is-a-complex-interplay-between-mismatched-peptide-binding-region-residues-hla-c-expression-and-hla-dpb1-disparities
#16
Florence Bettens, Stéphane Buhler, Jean-Marie Tiercy
HLA-C locus mismatches (MMs) are the most frequent class I disparities in unrelated hematopoietic stem cell transplantation (HSCT) and have a detrimental impact on clinical outcome. Recently, a few retrospective clinical studies have reported some variability in the immunogenicity of HLA-C incompatibilities. To get better insight into presumably permissive HLA-C MMs, we have developed a one-way in vitro mixed lymphocyte reaction (MLR) assay allowing to quantify activated CD56(-)CD137(+)CD8(+) lymphocytes in HLA-C incompatible combinations...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28007555/regular-biennial-cycles-in-epidemics-caused-by-parametric-resonance
#17
Shiyang Chen, Bogdan Epureanu
The interaction between nonlinearity and seasonal forcing in childhood infectious diseases often leads to multiyear cycles with large amplitude. Regular biennial cycles in particular were observed in measles reports throughout the world. The objective of this paper is to understand the mechanism of such biennial cycles, especially the conditions under which the large amplitude biennial oscillation might appear. It is proposed that such biennial cycles are caused by parametric resonance, which might occur when varying the parameter at a frequency close to twice the natural frequency of the system...
December 20, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27999544/mitragyna-speciosa-leaf-extract-exhibits-antipsychotic-like-effect-with-the-potential-to-alleviate-positive-and-negative-symptoms-of-psychosis-in-mice
#18
Kamini Vijeepallam, Vijayapandi Pandy, Thubasni Kunasegaran, Dharmani D Murugan, Murali Naidu
In this study, we investigated the antipsychotic-like effect of methanolic extract of Mitragyna speciosa leaf (MMS) using in vivo and ex vivo studies. In vivo studies comprised of apomorphine-induced climbing behavior, haloperidol-induced catalepsy, and ketamine-induced social withdrawal tests in mice whereas the ex vivo study was conducted utilizing isolated rat vas deferens preparation. Acute oral administration of MMS (50-500 mg/kg) showed an inverted bell-shaped dose-response in apomorphine-induced cage climbing behavior in mice...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27998204/construction-and-comparison-of-yeast-whole-cell-biosensors-regulated-by-two-rad54-promoters-capable-of-detecting-genotoxic-compounds
#19
Yongjie Tian, Yixin Lu, Xiuju Xu, Chao Wang, Tianqi Zhou, Xiangming Li
Two yeast enhanced green fluorescence protein (yEGFP) yeast reporter vectors, pR1558-yEGFP and pR406-yEGFP, which are regulated by two RAD54 promoters containing 406-bp and 1558-bp DNA sequences, respectively, were constructed using molecular biological techniques and transformed into yeast for the screening of genotoxins. The constructed biosensors were named W303-1A/R1558-yEGFP and W303-1A/R406-yEGFP. To quantify biosensor performance, both transformed yeast cells were exposed to multiple doses of genotoxins including methylmethane sulfonate (MMS; a DNA alkylating agent), 4-nitroquinoline-N-oxide (4-NQO; a DNA cleavage agent), 5-fluorouracil (5-Fu; an inhibitor of polymerases and topoisomerases) and colchicine and canavanine (affecting other biochemical activities)...
December 20, 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27994411/comparative-evaluation-of-calcium-silicate-based-dentin-substitute-biodentine-%C3%A2-and-calcium-hydroxide-pulpdent-in-the-formation-of-reactive-dentin-bridge-in-regenerative-pulpotomy-of-vital-primary-teeth-triple-blind-randomized-clinical-trial
#20
Navneet Grewal, Rubica Salhan, Nirapjeet Kaur, Hemal Bipin Patel
BACKGROUND: Considering the biological concerns of calcium hydroxide (CH) as a pulpotomy agent, an alternative silicate based dentin substitute i.e. Biodentine (Ca3SiO5) was evaluated clinically and radiographically. AIMS: To evaluate the effectiveness of dentin substitute (Biodentine) in regenerative pulpotomy of vital primary teeth that would giv a biological base to its use in forming reactive dentin bridge and overcoming the drawbacks of calcium hydroxide. MATERIAL AND METHODS: Randomised clinical trial on 40 bilateral carious primary molars in 20 participant children (aged 5-10 years) was carried out by same operator using Ca3SiO5(group-1) and CH (group-2) as vital pulpotomy agents...
October 2016: Contemporary Clinical Dentistry
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