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https://www.readbyqxmd.com/read/28213703/proximal-tibial-bony-and-meniscal-slopes-are-higher-in-acl-injured-subjects-than-controls-a-comparative-mri-study
#1
Ashraf Elmansori, Timothy Lording, Raphaël Dumas, Khalifa Elmajri, Philippe Neyret, Sébastien Lustig
PURPOSE: Increased tibial slope is reported as a risk factor of non-contact anterior cruciate ligament (ACL) injury, but the effect of the soft tissues on slope remains unclear. The primary aims of this study were to compare the tibial bony and soft tissue slopes between patients with and without ACL injury, and to investigate the relationship between the meniscal slopes (MS) and the tibial bony slope. Our hypothesis was that the menisci would correct the inclination of the bony tibial slope towards the horizontal...
February 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28205273/in-vitro-responses-to-known-in-vivo-genotoxic-agents-in-mouse-germ-cells
#2
Khaled Habas, Martin H Brinkworth, Diana Anderson
Genotoxic compounds have induced DNA damage in male germ cells and have been associated with adverse clinical outcomes including enhanced risks for maternal, paternal and offspring health. DNA strand breaks represent a great threat to the genomic integrity of germ cells. Such integrity is essential to maintain spermatogenesis and prevent reproduction failure. The Comet assay results revealed that the incubation of isolated germ cells with n-ethyl-n-nitrosourea (ENU), 6-mercaptopurine (6-MP) and methyl methanesulphonate (MMS) led to increase in length of Olive tail moment and % tail DNA when compared with the untreated control cells and these effects were concentration-dependent...
February 16, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28195382/contribution-of-atm-and-atr-kinase-pathways-to-p53-mediated-response-in-etoposide-and-methyl-methanesulfonate-induced-dna-damage
#3
Bin Sun, Susan M Ross, Sean Rowley, Yeyejide Adeleye, Rebecca A Clewell
p53 is a key integrator of cellular response to DNA damage, supporting post-translational repair and driving transcription-mediated responses including cell cycle arrest, apoptosis, and repair. DNA damage sensing kinases recognize different types of DNA damage and initiate specific responses through various post-translational modifications of p53. This study evaluated chemical specificity of the p53 pathway response by manipulating p53 or its upstream kinases and assessing the effect on DNA damage and cellular responses to prototype chemicals: etoposide (ETP, topoisomerase II inhibitor) and methyl methane sulfonate (MMS, alkylating agent)...
February 14, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28183985/characterization-of-pph3-mediated-dephosphorylation-of-rad53-during-methyl-methanesulfonate-induced-dna-damage-repair-in-candida-albicans
#4
Guangyin Yao, Junhua Wan, Qizheng Liu, Chunhua Mu, Yue Wang, Jianli Sang
Genotoxic stress causes DNA damage or stalled DNA replication and filamentous growth in the pathogenic fungus Candida albicans The DNA checkpoint kinase Rad53 critically regulates by phosphorylation effectors that execute the stress response. Rad53 itself is activated by phosphorylation and inactivated by dephosphorylation. Previous studies have suggested that the phosphatase Pph3 dephosphorylates Rad53. Here, we used mass spectrometry and mutagenesis to identify Pph3 dephosphorylation sites on Rad53 in C. albicans We found that serine residues 351, 461, and 477, which were dephosphorylated in wild-type cells during the recovery from DNA damage caused by methyl methanesulfonate (MMS), remained phosphorylated in pph3Δ/Δ cells...
February 9, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28179111/role-of-the-oxidized-form-of-xrcc1-in-protection-against-extreme-oxidative-stress
#5
Julie K Horton, Hannah J Seddon, Ming-Lang Zhao, Natalie R Gassman, Agnes K Janoshazi, Donna F Stefanick, Samuel H Wilson
The multi-domain protein XRCC1 is without catalytic activity, but can interact with a number of known repair proteins. The interaction between the N-terminal domain (NTD) of XRCC1 and DNA polymerase β (pol β) is critical for recruitment of pol β to sites of DNA damage and repair. Crystallographic and NMR approaches have identified oxidized and reduced forms of the XRCC1 NTD, and the corresponding forms of XRCC1 have been identified in cultured mouse fibroblast cells. Both forms of NTD interact with pol β, but the interaction is much stronger with the oxidized form...
February 4, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28178008/processing-adipose-rich-mohs-samples-a-comparative-study-of-effectiveness-of-pretreatment-with-liquid-nitrogen-versus-flash-freezing-spray
#6
Jeave Reserva, Zachary Kozel, Cindy Krol, Jodi Speiser, William Adams, Rebecca Tung
Processing of adipose-rich Mohs micrographic surgery (MMS) specimens poses challenges that may preclude complete margin evaluation. In this setting, the value of additional freezing methods using various cooling agents has not been previously investigated. The aim of this study is to compare the frozen section quality of high-adipose Mohs specimens processed without additional cooling treatments versus those pretreated with 1,1,1,2-tetrafluoroethane (TFE) or liquid nitrogen (LN2). A set of 3 sections were each taken from 24 adipose-rich Mohs micrographic surgery specimens...
January 26, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28178005/surgical-treatment-and-outcomes-of-patients-with-extramammary-paget-disease-a-cohort-study
#7
Sharon J Kim, Agnieszka K Thompson, Adeel S Zubair, Clark C Otley, Christopher J Arpey, Christian L Baum, Randall K Roenigk, Christine M Lohse, Jerry D Brewer
BACKGROUND: Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option. OBJECTIVE: To compare long-term outcomes after treatment with MMS or excision for primary EMPD. METHODS AND MATERIALS: Retrospective cohort review was conducted for 207 patients with EMPD treated at Mayo Clinic in Rochester, MN, between 1961 and 2012...
February 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28173693/pro-apoptotic-role-of-the-human-ypel5-gene-identified-by-functional-complementation-of-a-yeast-moh1%C3%AE-mutation
#8
Ji Young Lee, Do Youn Jun, Ju Eun Park, Gi Hyun Kwon, Jong-Sik Kim, Young Ho Kim
To examine the pro-apoptotic role of the human ortholog (YPEL5) of the Drosophila Yippee protein, the cell viability of Saccharomyces cerevisiae mutant strain with deleted MOH1, the yeast ortholog, were compared with that of the wild-type (WT)-MOH1 strain after exposure to different apoptogenic stimulants, including UV irradiation, methyl methanesulfonate (MMS), camptothecin (CPT), heat shock, and hyperosmotic shock. The moh1Δ mutant exhibited an enhanced cell viability compared with the WT-MOH1 strain when treated with lethal UV irradiation, 1...
February 7, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28146288/outcomes-and-prognostic-factors-of-surgical-treatments-for-brachycephalic-obstructive-airway-syndrome-in-3-breeds
#9
Nai-Chieh Liu, Gerhard U Oechtering, Vicki J Adams, Lajos Kalmar, David R Sargan, Jane F Ladlow
OBJECTIVE: To determine prognostic indicators for the surgical treatment of brachycephalic obstructive airway syndrome (BOAS) and to compare the prognosis of 2 multilevel surgical procedures. STUDY DESIGN: Prospective clinical study. SAMPLE POPULATION: Client-owned pugs, French bulldogs, and bulldogs (n = 50). METHODS: Noninvasive whole-body barometric plethysmography (WBBP) was used to assess respiratory function before, 1 month and 6 months after upper airway corrective surgery...
February 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28139264/clinical-and-pathologic-factors-associated-with-subclinical-spread-of-invasive-melanoma
#10
Thuzar M Shin, Waqas R Shaikh, Jeremy R Etzkorn, Joseph F Sobanko, David J Margolis, Joel M Gelfand, Emily Y Chu, Rosalie Elenitsas, Christopher J Miller
BACKGROUND: Indications to treat invasive melanoma with Mohs micrographic surgery (MMS) or analogous techniques with exhaustive microscopic margin assessment have not been defined. OBJECTIVE: Identify clinical and histologic factors associated with subclinical spread of invasive melanoma. METHODS: This retrospective, cross-sectional study evaluated 216 invasive melanomas treated with MMS and melanoma antigen recognized by T cells 1 immunostaining...
January 28, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28133492/minimization-of-male-suffering-social-perception-of-victims-and-perpetrators-of-opposite-sex-sexual-coercion
#11
Anna Magda Studzinska, Denis Hilton
Studies show equal impact of sexual harassment (SH) on men and women, whereas lay perceptions are that women suffer more. We identify the phenomenon of minimization of male suffering (MMS), which occurs when people assume that SH has less effect on men's well-being and which results in the perpetrators of SH on men being evaluated less harshly. To verify whether these effects occur, we conducted two studies in which we presented stories describing acts of sexual coercion (SC, study 1) and SC or financial coercion (FC, study 2) and measured the perceived suffering of victims and the perception of the perpetrators...
2017: Sexuality Research & Social Policy: Journal of NSRC: SR & SP
https://www.readbyqxmd.com/read/28132937/adapting-the-mini-mental-status-to-the-context-of-the-west-indies
#12
Lidvine Godaert, Claire Godard-Sebillotte, Lionel Bousquet, Emmanuel Devouche, Laurence Hugonot-Diener, Joëlle Nuissier, Frank Triboulet, Jean-Luc Fanon
The mini mental state examination (MMSE) has become a benchmark for the screening and follow-up of cognitive impairment. The numerous translations of the MMS into other languages attest to its popularity. Clinical practice suggests that the consensual French version from the Greco (Groupe de réflexion sur les évaluations cognitives - Research working group for cognitive assessment) is not adapted to the West-Indies population because of the low socio-economic level and the widespread use of the Creole language among the elderly population...
January 27, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28131761/sirt3-mediates-decrease-of-oxidative-damage-and-prevention-of-ageing-in-porcine-fetal-fibroblasts
#13
Xiaoxian Xie, Liangliang Wang, Binggong Zhao, Yangyang Chen, Jiaqi Li
AIMS: Sirtuin 3 (SIRT3) is a mitochondria-specific protein required for the deacetylation of metabolic enzymes and the action of oxidative phosphorylation by acting as a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase. SIRT3 increases oxidative stress resistance and prevents mitochondrial decay associated with ageing in response to caloric restriction. However, the effects of SIRT3 on oxidative damage and ageing are not well understood. We investigated the physiological functions of porcine SIRT3 on the damage and ageing in porcine fetal fibroblasts (PFFs)...
January 25, 2017: Life Sciences
https://www.readbyqxmd.com/read/28120418/immunohistochemical-detection-of-lymph-node-dtcs-in-patients-with-node-negative-hnscc
#14
Christoph Sproll, Anna Karen Freund, Andrea Hassel, Marianne Hölbling, Verena Aust, Sebastian H Storb, Jörg Handschel, Carina Teichmann, Rita Depprich, Bianca Behrens, Rui Pedro Lousa das Neves, Norbert R Kübler, Peter Kaiser, Stephan E Baldus, Csaba Tóth, Wolfgang Kaisers, Nikolas H Stoecklein
This study was performed to systematically assess the prevalence, topography and prognostic impact of disseminated tumor cells (DTCs) in lymph nodes (LN) of patients with primary, regional and distant metastasis-free head and neck squamous cell carcinoma (HNSCC) who underwent resection with elective neck dissection. From the routinely processed resection specimen, we could prospectively analyze a total of 1.137 exactly mapped LNs of 50 pN0-HNSCC patients, classified as tumor free by routine histopathology. Three immunohistochemistry (IHC) assays using antibodies directed against CK5/14, a broad spectrum of CKs (1-8, 10, 14-16, and 19), and CD44v6, respectively, were applied on 4...
January 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28118378/dna-polymerases-imuc-and-dinb-are-involved-in-dna-alkylation-damage-tolerance-in-pseudomonas-aeruginosa-and-pseudomonas-putida
#15
Tatjana Jatsenko, Julia Sidorenko, Signe Saumaa, Maia Kivisaar
Translesion DNA synthesis (TLS), facilitated by low-fidelity polymerases, is an important DNA damage tolerance mechanism. Here, we investigated the role and biological function of TLS polymerase ImuC (former DnaE2), generally present in bacteria lacking DNA polymerase V, and TLS polymerase DinB in response to DNA alkylation damage in Pseudomonas aeruginosa and P. putida. We found that TLS DNA polymerases ImuC and DinB ensured a protective role against N- and O-methylation induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in both P...
2017: PloS One
https://www.readbyqxmd.com/read/28114205/two-suturing-techniques-for-the-prevention-and-treatment-of-nasal-valve-collapse-after-mohs-micrographic-surgery
#16
Anis Miladi, Joseph W McGowan, Heidi B Donnelly
BACKGROUND: Tumor extirpation of nonmelanoma skin cancer (NMSC) adjacent to the alar groove, using Mohs micrographic surgery (MMS), may risk causing internal nasal valve (INV) collapse, resulting in reduced airflow during inspiration. There are many surgical options described in the literature to repair INV collapse as a postoperative corrective procedure, but few exist as an intra-operative preventative procedure. OBJECTIVE: The authors present 2 distinct methods to prevent and treat INV collapse during the repair of a perialar surgical defect caused by MMS...
January 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28111686/rapidly-recoverable-anti-fatigue-super-tough-double-network-hydrogels-reinforced-by-macromolecular-microspheres
#17
Jiliang Hou, Xiuyan Ren, Shuang Guan, Lijie Duan, Guang Hui Gao, Yu Kuai, Huixuan Zhang
In this study, a novel strategy was designed to prepare rapidly recoverable, anti-fatigue, super-tough double-network hydrogels by introducing macromolecular microspheres (MMs) as cross-linking centers for hydrophobic associations. MMs were prepared via emulsion polymerization using butyl acrylate (BA) as a main component and dicyclopentyl acrylate (DCPA) as a cross-linker. Then, a double-network (DN) hydrogel was prepared using gelatin as the first network and a copolymer of acrylamide and hexadecyl methacrylate stabilized by MMs as the second network...
January 23, 2017: Soft Matter
https://www.readbyqxmd.com/read/28107578/patient-satisfaction-and-the-waiting-room-in-mohs-surgery-appropriate-pre-warning-may-abrogate-boredom
#18
F R Ali, F Al-Niaimi, E E Craythorne, R Patalay, R Mallipeddi
Patient satisfaction in dermatology consultations has rightly been afforded attention by De Salins and colleagues.(1) When considering the patient journey through an outpatient appointment, a significant proportion of time is spent in the waiting room, a period which is poorly understood and may contribute to patient anxiety and perceived satisfaction with treatment.(2) In our outpatient Mohs micrographic surgery (MMS) unit, patients may be waiting for several hours in total whilst histological specimens are processed and analysed, prior to reconstruction, particularly if multiple MMS stages are needed...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28104119/association-of-the-number-of-hla-dr-mismatches-with-early-post-transplant-acute-cellular-rejection-among-heart-transplantation-recipients-a-cohort-study-in-japanese-population
#19
D Nitta, K Kinugawa, T Imamura, J Iino, M Endo, E Amiya, M Hatano, O Kinoshita, K Nawata, M Ono, I Komuro
BACKGROUND: Although many risk factors are reported about graft rejection after heart transplantation (HTx), the effect of HLA mismatch (MM) still remains unknown, especially in the Japanese population. The aim of the present study was to investigate the influence of HLA MM on graft rejection among HTx recipients in Japan. METHODS: We retrospectively investigated the association of the number of HLA MM including class I (A, B) and class II (DR) (for each locus MM: 0 to 2, total MM: 0 to 6) and the incidence of moderate to severe acute cellular rejection (ACR) confirmed by endomyocardial biopsy (International Society for Heart and Lung Transplantation grade ≥ 3A/2R) within 1 year after HTx...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28095787/the-effects-of-habitual-functional-training-on-physical-functioning-in-patients-after-hip-fracture-the-protocol-of-the-hipfrac-study
#20
Kristi Elisabeth Heiberg, Vigdis Bruun-Olsen, Astrid Bergland
BACKGROUND: The survivors after hip fracture often report severe pain and loss of physical functioning. The poor outcomes cause negative impact on the person's physical functioning and quality of life and put a financial burden on society. Rehabilitation is important to improve physical functioning after hip fracture. To maintain the continuity in rehabilitation we have an assumption that it is of utmost importance to continue and progress the functional training that already started at the hospital, while the patients are transferred to short-term stays in a nursing home before they are returning to home...
January 17, 2017: BMC Geriatrics
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