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https://www.readbyqxmd.com/read/29904909/inactivation-of-tp53-and-pten-drives-rapid-development-of-pleural-and-peritoneal-malignant-mesotheliomas
#1
Eleonora Sementino, Craig W Menges, Yuwaraj Kadariya, Suraj Peri, Jinfei Xu, Zemin Liu, Richard G Wilkes, Kathy Q Cai, Frank J Rauscher, Andres J Klein-Szanto, Joseph R Testa
Malignant mesothelioma (MM) is a therapy-resistant cancer arising primarily from the lining of the pleural and peritoneal cavities. The most frequently altered genes in human MM are cyclin-dependent kinase inhibitor 2A (CDKN2A), which encodes components of the p53 (p14ARF) and RB (p16INK4A) pathways, BRCA1-associated protein 1 (BAP1), and neurofibromatosis 2 (NF2). Furthermore, the p53 gene (TP53) itself is mutated in ~15% of MMs. In many MMs, the PI3K-PTEN-AKT-mTOR signaling node is hyperactivated, which contributes to tumor cell survival and therapeutic resistance...
June 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29900551/collagen-disruption-as-a-marker-for-basal-cell-carcinoma-in-presurgical-margin-detection
#2
Pooyan Rohani, Anna N Yaroslavsky, Xin Feng, Peter Jermain, Tarek Shaath, Victor A Neel
INTRODUCTION AND OBJECTIVE: Nonmelanoma skin cancers (NMSCs) are the most common malignancies in the United States. Surgery is the most common treatment for these tumors, but pre-operative identification of surgical margins is challenging. The objective in this study was to determine whether optical polarization imaging (OPI) could be used prior to surgery to detect the extent of subclinical tumor spread by monitoring disruption in collagen. MATERIALS AND METHODS: OPI is a non-invasive and rapid imaging modality that highlights the structure of dermal collagen...
June 14, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29894525/perianal-basal-cell-carcinoma-treated-with-mohs-micrographic-surgery
#3
Michael Ryan, Hamad Alabdulrazzaq, Jennifer Toyohara
Perianal basal cell carcinoma (BCC) is a rare lesion that accounts for less than 0.08% of all BCCs. It is challenging to diagnose, as it can be overlooked or mistaken for an inflammatory dermatosis. When discovered early and treated properly, BCC is associated with low mortality and a good prognosis. Thorough total-body skin examinations and biopsy of suspected lesions found in the perianal region is recommended. We present a case of a superficial nodular perianal BCC that was discovered following a routine total-body skin examination and was treated with Mohs micrographic surgery (MMS)...
May 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29894522/mohs-micrographic-surgery-for-digital-melanoma-and-nonmelanoma-skin-cancers
#4
Zain Husain, Rina M Allawh, Ali Hendi
Treatment of digital skin cancers is challenging due to various functional and cosmetic implications. Traditionally, routine treatment includes radical amputation, but digital skin cancers are increasingly being treated with more conservative, tissue-sparing methods such as Mohs micrographic surgery (MMS), which provides excellent tissue conservation and margin control when used to treat melanoma and nonmelanoma skin cancers (NMSCs). In this study, we conducted a retrospective chart review to evaluate clinical outcomes following MMS for treatment of digital melanoma and NMSCs...
May 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29894433/eccrine-porocarcinoma-new-insights-and-a-systematic-review-of-the-literature
#5
Azadeh Nazemi, Shauna Higgins, Reyna Swift, Gino In, Kimberly Miller, Ashley Wysong
BACKGROUND: Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm with high potential for morbidity and mortality. Due to its rarity, there is a paucity of data profiling diagnosis, work-up, and management. OBJECTIVE: To consolidate reported information on demographics, diagnostics, clinical behavior, treatment modalities, and patient outcomes in EPC to provide a reference tool to optimize diagnosis and management. METHODS: A comprehensive PubMed search was performed from 1963 to November 2017 using PRISMA guidelines...
June 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29894432/a-predictive-model-for-primary-closure-lengths-in-mohs-surgery-based-on-skin-cancer-type-dimensions-and-location
#6
Zachary A Theroux, Adam B Blechman, Mark A Russell
BACKGROUND: Surgical scar length is a common concern among patients undergoing Mohs micrographic surgery (MMS). OBJECTIVE: This study evaluates 3 metrics of preoperative lesion size to determine which correlates best with primary linear closure lengths for nonmelanoma skin cancers (NMSCs) treated with MMS. This metric is then used to develop predictive models for linear closure lengths in 10 different anatomical regions. MATERIALS AND METHODS: A retrospective study of 4,049 NMSCs treated with MMS and repaired with primary linear closure was conducted...
June 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29890839/mohs-micrographic-surgery-dermatopathology-concordance-in-canada-a-single-institution-experience
#7
Justin C Chia, Marie S Abi Daoud, Tyler S Williamson, Habib A Kurwa
BACKGROUND: Mohs micrographic surgery (MMS) is a surgical modality that achieves high cure rates of nonmelanoma skin cancers but is dependent on accurate histologic examination of surgical margins. Therefore, quality assurance is essential to ongoing assessment of histological margins. OBJECTIVES: To prospectively determine the concordance rate between a Mohs surgeon (MS) and dermatopathologist (DP) with respect to tumour status (ie, present or absent) and tumour type...
June 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29883431/registration-of-panoramic-fish-eye-image-sequence-and-lidar-points-using-skyline-features
#8
Ningning Zhu, Yonghong Jia, Shunping Ji
We propose utilizing a rigorous registration model and a skyline-based method for automatic registration of LiDAR points and a sequence of panoramic/fish-eye images in a mobile mapping system (MMS). This method can automatically optimize original registration parameters and avoid the use of manual interventions in control point-based registration methods. First, the rigorous registration model between the LiDAR points and the panoramic/fish-eye image was built. Second, skyline pixels from panoramic/fish-eye images and skyline points from the MMS’s LiDAR points were extracted, relying on the difference in the pixel values and the registration model, respectively...
May 21, 2018: Sensors
https://www.readbyqxmd.com/read/29865089/efficacy-of-rituximab-in-refractory-generalized-anti-achr-myasthenia-gravis
#9
Océane Landon-Cardinal, Diane Friedman, Marguerite Guiguet, Pascal Laforêt, Nicholas Heming, Emmanuelle Salort-Campana, Fabienne Jouen, Yves Allenbach, Olivier Boyer, Lucienne Chatenoud, Bruno Eymard, Tarek Sharshar, Olivier Benveniste
BACKGROUND: Several retrospective case series have suggested rituximab (RTX) might improve patients with refractory Myasthenia Gravis (MG). OBJECTIVE: In this study, we aimed to evaluate prospectively the efficacy of RTX on muscle function in refractory generalized anti-acetylcholine receptor (AChR) MG patients. METHODS: Enrolled patients received 1 g of RTX at day 0, day 14, and 6-month follow-up (M6). The primary endpoint was improvement of muscle function at 12-month (M12) based on myasthenic muscle score (MMS)...
2018: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/29864110/hematologic-malignancies-associated-with-mediastinal-germ-cell-tumors-10-years-experience-at-thailand-s-national-pediatric-tertiary-referral-center
#10
Panjarat Sowithayasakul, Phakatip Sinlapamongkolkul, Jitsupa Treetipsatit, Nassawee Vathana, Nattee Narkbunnam, Kleebsabai Sanpakit, Jassada Buaboonnam
Mediastinal germ cell tumor (MGCT), which accounts for 1% to 3% of extragonadal germ cell tumors, has unique manifestations; it is associated with several types of hematologic malignancy, particularly myeloid neoplasm. The aim of this study was to report the 10-year incidence, clinical characteristics, and outcomes of MGCT at Thailand's national pediatric tertiary referral center. This retrospective study included patients diagnosed with MGCT at the Department of Pediatrics, Siriraj Hospital during 2005 to 2014...
June 1, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29859040/arabidopsis-nucleostemin-like-1-nsn1-regulates-cell-cycling-potentially-by-cooperating-with-nucleosome-assembly-protein-atnap1-1
#11
Zhen Wang, Xiaomin Wang, Bo Xie, Zonglie Hong, Qingchuan Yang
BACKGROUND: In mammals, nucleostemin (NS), a nucleolar GTPase, is involved in stem cell proliferation, embryogenesis and ribosome biogenesis. Arabidopsis NUCLEOSTEMIN-LIKE 1 (NSN1) has previously been shown to be essential for plant growth and development. However, the role of NSN1 in cell proliferation is largely unknown. RESULTS: Using nsn1, a loss-of-function mutant of Arabidopsis NSN1, we investigated the function of NSN1 in plant cell proliferation and cell cycle regulation...
June 1, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29849914/atorvastatin-downregulates-in-vitro-methyl-methanesulfonate-and-cyclophosphamide-alkylation-mediated-cellular-and-dna-injuries
#12
Carlos F Araujo-Lima, Larissa S A Christoni, Graça Justo, Maria N C Soeiro, Claudia A F Aiub, Israel Felzenszwalb
Statins are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, and this class of drugs has been studied as protective agents against DNA damages. Alkylating agents (AAs) are able to induce alkylation in macromolecules, causing DNA damage, as DNA methylation. Our objective was to evaluate atorvastatin (AVA) antimutagenic, cytoprotective, and antigenotoxic potentials against DNA lesions caused by AA. AVA chemopreventive ability was evaluated using antimutagenicity assays ( Salmonella /microsome assay), cytotoxicity, cell cycle, and genotoxicity assays in HepG2 cells...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29846341/patients-body-image-improves-after-mohs-micrographic-surgery-for-nonmelanoma-head-and-neck-skin-cancer
#13
Brandon T Beal, Emily K White, Anit K Behera, Amy E Zavell, Ashley E McGuinness, Holly Blangger, Eric S Armbrecht, Ian A Maher
BACKGROUND: Most skin cancers occur on the head and neck, areas of the body that are significant to an individual's body image (BI) perception. Poor BI is a robust risk factor for depression and decreased quality of life. Thus, patients with nonmelanoma head and neck skin cancer (NMHNSC) may be more vulnerable to BI disturbance and the negative sequelae of poor BI. OBJECTIVE: Describe the nature of BI concerns in patients diagnosed with NMHNSC and assess how BI changes with treatment...
May 24, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29845303/-field-tests-for-the-beta-version-of-the-icd-11-mms-in-germany-background-and-methods
#14
Jürgen Stausberg, Annette Pollex-Krüger, Sebastian C Semler, Ulrich Vogel, Holger Reinecke
BACKGROUND: The World Health Organization (WHO) has been developing the 11th revision of the International Classification of Diseases (ICD) since 2007. ICD-11 is different from the ICD-10 in volume and structure. Therefore, the WHO planned field tests with a coding of diagnoses and cases. OBJECTIVES: To describe the background of the field tests and their implementation in Germany. MATERIALS AND METHODS: Interested parties were invited to submit proposals through a call to the Association of the Scientific Medical Societies (AWMF)...
May 29, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29843966/cd59-deficiency-presenting-as-polyneuropathy-and-moyamoya-syndrome-with-endothelial-abnormalities-of-small-brain-vessels
#15
Christian Klemann, Janbernd Kirschner, Sandra Ammann, Horst Urbach, Olaf Moske-Eick, Barbara Zieger, Myriam Ricarda Lorenz, Klaus Schwarz, Soroush Doostkam, Stephan Ehl, Rudolf Korinthenberg
CD59 is involved in lymphocyte signal transduction and regulates complement-mediated cell lysis by inhibiting the membrane attack complex. In the cases reported so far, congenital isolated CD59 deficiency was associated with recurrent episodes of hemolytic anemia, peripheral neuropathy, and strokes. Here, we report on a patient from a consanguineous Turkish family, who had a first episode of hemolytic anemia at one month of age and presented at 14 months with acute Guillain-Barré syndrome (GBS). The child suffered repeated infection-triggered relapses leading to the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP)...
April 13, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29809054/effects-of-rapid-weight-loss-on-balance-and-reaction-time-in-elite-judo-athletes
#16
Jose Morales, Carla Ubasart, Mónica Solana-Tramunt, Luis-Millán González, David Fukuda, Emerson Franchini
Balance, reaction time, and strength are key factors affecting judo performance. While ample research exists examining potential strength changes caused by weight loss prior to competition, changes in balance and reaction time, have been overlooked. PURPOSE: The objective of this study was to examine the effects of rapid and progressive weight loss (RWL and PWL) on balance, reaction time, and strength in a group of elite judo athletes. METHODS: 38 female and male judo athletes (age = 20...
May 29, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29807908/mapping-dna-damage-dependent-genetic-interactions-in-yeast-via-party-mating-and-barcode-fusion-genetics
#17
J Javier Díaz-Mejía, Albi Celaj, Joseph C Mellor, Atina Coté, Attila Balint, Brandon Ho, Pritpal Bansal, Fatemeh Shaeri, Marinella Gebbia, Jochen Weile, Marta Verby, Anna Karkhanina, YiFan Zhang, Cassandra Wong, Justin Rich, D'Arcy Prendergast, Gaurav Gupta, Sedide Öztürk, Daniel Durocher, Grant W Brown, Frederick P Roth
Condition-dependent genetic interactions can reveal functional relationships between genes that are not evident under standard culture conditions. State-of-the-art yeast genetic interaction mapping, which relies on robotic manipulation of arrays of double-mutant strains, does not scale readily to multi-condition studies. Here, we describe barcode fusion genetics to map genetic interactions (BFG-GI), by which double-mutant strains generated via en masse "party" mating can also be monitored en masse for growth to detect genetic interactions...
May 28, 2018: Molecular Systems Biology
https://www.readbyqxmd.com/read/29797062/when-and-why-is-surgical-revascularization-indicated-for-the-treatment-of-moyamoya-syndrome-in-patients-with-rasopathies-a-systematic-review-of-the-literature-and-a-single-institute-experience
#18
REVIEW
Marcello Scala, Pietro Fiaschi, Valeria Capra, Maria Luisa Garrè, Domenico Tortora, Marcello Ravegnani, Marco Pavanello
BACKGROUND: Moyamoya disease (MMD) is a cerebrovascular disorder characterized by the progressive occlusion of the supraclinoid internal carotid artery (ICA), resulting in the formation of an abnormal cerebral vascular network. When MMD occurs in association with an underlying medical condition, including some distinctive genetic disorders, it is named moyamoya syndrome (MMS). The discrimination between MMD and MMS has been validated by recent genetic researches and international reviews...
May 24, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29788961/relationships-among-medication-adherence-lifestyle-modification-and-health-related-quality-of-life-in-patients-with-acute-myocardial-infarction-a-cross-sectional-study
#19
Yu-Mi Lee, Rock Bum Kim, Hey Jean Lee, Keonyeop Kim, Min-Ho Shin, Hyeung-Keun Park, Soon-Ki Ahn, So Young Kim, Young-Hoon Lee, Byoung-Gwon Kim, Heeyoung Lee, Won Kyung Lee, Kun Sei Lee, Mi-Ji Kim, Ki-Soo Park
BACKGROUND: The healthy adherer effect is a phenomenon in which patients who adhere to medical therapies tend to pursue health-seeking behaviors. Although the healthy adherer effect is supposed to affect health outcomes in patients with coronary artery disease, evaluation of its presence and extent is not easy. This study aimed to assess the relationship between medication adherence and lifestyle modifications and health-related quality of life among post-acute myocardial infarction (AMI) patients...
May 22, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29786877/morphomic-malnutrition-score-a-standardized-screening-tool-for-severe-malnutrition-in-adults
#20
Christopher Lee, Erica Raymond, Brian A Derstine, Joshua M Glazer, Rebecca Goulson, Avinash Rajasekaran, Jill Cherry-Bukowiec, Grace L Su, Stewart C Wang
BACKGROUND: Granular diagnostic criteria for adult malnutrition are lacking. OBJECTIVE: This study uses analytic morphomics to define the Morphomic Malnutrition Score (MMS), a robust screening tool for severe malnutrition. METHODS: The study population (n = 643) consisted of 2 cohorts: 1) 124 emergency department patients diagnosed with severe malnutrition by a registered dietitian (RD) and an available computed tomography (CT) scan within 2 days of RD evaluation, and 2) 519 adult kidney donor candidates to represent a healthy cohort...
May 22, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
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