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Emerson H Padoveze, Nilton Di Chiacchio, Jorge Ocampo-Garza, Selma S Cernea, Walter Belda, Mirian N Sotto
BACKGROUND: The macrophages associated with solid tumors are related to the progression or regression of tumors, depending on the differentiation in M1 or M2. M2 subtype promotes angiogenesis, remodeling, and tissue repair (tumor proliferation). In contrast, M1 produces toxic mediators and presents antigens, destroying microorganisms and tumor cells. The microenvironment of most aggressive forms of basal cell carcinoma (BCC) shows an increase in macrophages due to M2 phenotype compared to noninvasive forms...
October 9, 2017: International Journal of Dermatology
Franklin C Kenechukwu, Anthony A Attama, Emmanuel C Ibezim, Petra O Nnamani, Chukwuebuka E Umeyor, Emmanuel M Uronnachi, Thaddeus H Gugu, Mumuni A Momoh, Kenneth C Ofokansi, Paul A Akpa
The use of conventional vaginal formulations of miconazole nitrate (MN) in the treatment of deep-seated VVC (vulvovaginal candidiasis) is limited by poor penetration capacity and low solubility of MN, short residence time and irritation at the application site. Surface-modified mucoadhesive microgels were developed to minimize local irritation, enhance penetration capacity and solubility and prolong localized vaginal delivery of MN for effective treatment of deep-seated VVC. Solid lipid microparticles (SLMs) were prepared from matrices consisting of hydrogenated palm oil (Softisan® 154, SF) and super-refined sunseed oil (SO) with or without polyethylene glycol (PEG)-4000, characterized for physicochemical performance and used to prepare mucoadhesive microgels (MMs) encapsulating MN, employing Polycarbophil as bioadhesive polymer...
October 3, 2017: European Journal of Pharmaceutical Sciences
Naif M Alsubaie, Ahmed A Youssef, Naser El-Sheimy
This paper introduces a new method which facilitate the use of smartphones as a handheld low-cost mobile mapping system (MMS). Smartphones are becoming more sophisticated and smarter and are quickly closing the gap between computers and portable tablet devices. The current generation of smartphones are equipped with low-cost GPS receivers, high-resolution digital cameras, and micro-electro mechanical systems (MEMS)-based navigation sensors (e.g., accelerometers, gyroscopes, magnetic compasses, and barometers)...
September 30, 2017: Sensors
Ying Zhou, Jian-Hua Yi, Li Liu, Xiaoping Wang, Liang Dong, Ai-Lian Du
Background Mitochondrial myopathies (MMs) are mainly presented with chronic muscle weakness and accompanied with other syndromes. MM with acute respiratory insufficiency is rare. Aims To reveal the clinical, pathological, and molecular characteristics of a life-threatening mitochondrial myopathy (MM). Methods Muscle biopsy and enzyme staining were performed in skeletal muscles. Mitochondrial DNA sequencing was analyzed and heteroplasmy were quantified by pyrosequencing. Results All three patients had tachycardia, acute lactic acidosis, dyspnea, and sudden severe muscle weakness...
October 2, 2017: International Journal of Neuroscience
Hauh-Jyun Candy Chen, Sun Wai Ip, Fu-Di Lin
Alkylating agents contained in cigarettes smoke might be related to cancer development. Post-translational protein methylation and ethylation may cause alteration of protein functions. Human hemoglobin (Hb) has been a target for molecular dosimetry because of its easy accessibility. The goal of this study is to investigate the relationship between the levels of methylation and ethylation at specific sites of Hb with smoking. Because of the low extent of modification of Hb isolated from blood, the methylation and ethylation sites were identified in Hb incubated with a methylating agent (methyl methanesulfonate, MMS) and ethylating agent (ethyl methanesulfonate, EMS), respectively, by accurate mass measurements...
October 2, 2017: Chemical Research in Toxicology
Jinrong Feng, Yinong Duan, Yongwei Qin, Wei Sun, Zhong Zhuang, Dandan Zhu, Linghuo Jiang
Protein phosphatase PP4 is composed of one catalytic subunit and one or two regulatory subunits and conserved in eukaryotic cells. The catalytic subunit CaPph3 forms a complex with the regulatory subunit CaPsy2, which dephosphorylates activated CaRad53 during adaptation to and recovery from MMS-mediated DNA damage. We show here that the N-terminal Y33A mutation of CaPsy2 blocks the interaction between CaPph3 and CaRad53, the deactivation of CaRad53 and the morphologic switch in recovery from genotoxic stress...
September 22, 2017: International Journal of Medical Microbiology: IJMM
Muneeb Ilyas, Collin M Costello, Nan Zhang, Amit Sharma
BACKGROUND: The ABCDE (with A standing for asymmetry, B for border irregularity, C for color variegation, D for diameter larger than 6 mm, and E for evolution) rule for melanoma (MM) recognition is widely taught in the general population. The ugly duckling (UD) sign is an alternate MM recognition strategy that is not generally taught. OBJECTIVE: To compare the sensitivity, specificity, and accuracy of MM recognition with UD sign and the ABCD rule in a general population...
September 27, 2017: Journal of the American Academy of Dermatology
Said Dahbour, Fatima Jamali, Dana Alhattab, Ali Al-Radaideh, Osama Ababneh, Nosaiba Al-Ryalat, Muawyeh Al-Bdour, Bayan Hourani, Mohammed Msallam, Murad Rasheed, Ammar Huneiti, Yacoub Bahou, Emad Tarawneh, Abdalla Awidi
AIMS: This open-label prospective phase I/IIa clinical study used autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) followed by mesenchymal stromal cells conditioned media (MSC-CM) for the first time to treat multiple sclerosis (MS) patients. The primary goal was to assess the safety and feasibility and the secondary was efficacy. The correlation between the MSC-CM content and treatment outcome was investigated. METHODS: Ten MS patients who failed conventional therapy were enrolled...
November 2017: CNS Neuroscience & Therapeutics
Israel Barco, MCarmen Vidal, Manel Fraile, Emili Masferrer, Leo Barco, Didac Barco, Cinthya J Baez, Nuria Giménez, Antoni Pessarrodona, Antonio García-Fernández
BACKGROUND: Erosive adenoma of the nipple (EAN) is a benign condition that involves major ducts of the nipple. Its clinical presentation may resemble other disorders. Complete removal of the nipple is often suggested because of frequent relapse. However, adverse cosmetic and functional results have prompted clinicians to look for other more conservative options. AIMS: To present a case of EAN successfully treated using Mohs micrographic surgery (MMS) and summarize differential diagnosis and treatment...
September 27, 2017: International Journal of Dermatology
Nathália Oliveira Acésio, Guilherme Scarano Carrijo, Thales Henrique Batista, Jaqueline Lopes Damasceno, Mariana Beltrame Côrrea, Marcos Gomide Tozatti, Wilson Roberto Cunha, Denise Crispim Tavares
The popular use of Annona muricata L. is based upon a range of medicinal purposes, and the plant exhibits biological activities including antihyperglycemic, antiparasitic, and antitumor activities. The objectives of this study were to examine the antioxidant, cytotoxic, and genotoxic potential of the hydroalcoholic extract of A. muricata leaves (AMEs), as well as its effects on genotoxicity induced by methyl methanesulfonate (MMS) and hydrogen peroxide (H2O2). The results using 2,2-diphenyl-1-picrylhydrazyl assay showed that AME was able to scavenge 44...
September 28, 2017: Journal of Toxicology and Environmental Health. Part A
Daniela Martini, Beatrice Biasini, Stefano Rossi, Ivana Zavaroni, Giorgio Bedogni, Marilena Musci, Carlo Pruneti, Giovanni Passeri, Marco Ventura, Daniela Galli, Prisco Mirandola, Marco Vitale, Alessandra Dei Cas, Riccardo C Bonadonna, Daniele Del Rio
All the requests for authorisation to bear health claims under Articles 13(5) and 14 in the context of appetite ratings and weight management have received a negative opinion by the European Food Safety Authority (EFSA), mainly because of the insufficient substantiation of the claimed effects (CEs). This manuscript results from an investigation aimed to collect, collate and critically analyse the information related to outcome variables (OVs) and methods of measurement (MMs) in the context of appetite ratings and weight management compliant with Regulation 1924/2006...
September 28, 2017: International Journal of Food Sciences and Nutrition
Rakesh Patel, Robert Strimling, Stephen Doggett, Mark Willoughby, Kenneth Miller, Lawrence Dardick, Erick Mafong
PURPOSE: High-dose-rate electronic brachytherapy (EBT) provides a non-surgical treatment option for non-melanoma skin cancer (NMSC). This matched-pair cohort study compared the outcomes of treatment with EBT to those of Mohs micrographic surgery (MMS) in patients with NMSC. MATERIAL AND METHODS: At four treatment centers, patients treated with EBT were case matched to patients treated with MMS based on retrospectively-collected patient age, lesion size, location and type, and year of treatment...
August 2017: Journal of Contemporary Brachytherapy
M Zhou, J Berchem, R J Walker, M El-Alaoui, X Deng, E Cazzola, G Lapenta, M L Goldstein, W R Paterson, Y Pang, R E Ergun, B Lavraud, H Liang, C T Russell, R J Strangeway, C Zhao, B L Giles, C J Pollock, P-A Lindqvist, G Marklund, F D Wilder, Y V Khotyaintsev, R B Torbert, J L Burch
We report unambiguous in situ observation of the coalescence of macroscopic flux ropes by the magnetospheric multiscale (MMS) mission. Two coalescing flux ropes with sizes of ∼1  R_{E} were identified at the subsolar magnetopause by the occurrence of an asymmetric quadrupolar signature in the normal component of the magnetic field measured by the MMS spacecraft. An electron diffusion region (EDR) with a width of four local electron inertial lengths was embedded within the merging current sheet. The EDR was characterized by an intense parallel electric field, significant energy dissipation, and suprathermal electrons...
August 4, 2017: Physical Review Letters
David M Wang, Frederick C Morgan, Robert J Besaw, Chrysalyne D Schmults
BACKGROUND: Analyses of skin cancer procedures adjusted for population changes are needed. OBJECTIVE: To describe trends in skin cancer-related biopsies and procedures in Medicare beneficiaries. METHODS: An ecological study of Medicare claims for skin biopsies and skin cancer procedures, 2000-2015. RESULTS: Biopsies increased 142%, and skin cancer procedures increased 56%. Mohs micrographic surgery (MMS) utilization increased on head/neck, hands/feet, and genitalia (11% to 27% of all treatment procedures) but was low on trunk/extremities (1% to 4%)...
September 22, 2017: Journal of the American Academy of Dermatology
Tina Vajdi, Robert Eilers, Shang I Brian Jiang
BACKGROUND: Mohs micrographic surgery (MMS) is used to treat certain high-risk non-melanoma skin cancers (NMSC) due to its high cure rate. However, clinical recurrences do occur in a small number of cases. OBJECTIVE: We examined specific clinical characteristics associated with NMSC recurrences following MMS. METHODS: We employed a retrospective chart review of the 1467 cases of NMSC that underwent MMS at UC San Diego from January 1, 2008 through December 31, 2009...
January 2017: Journal of Clinical and Investigative Dermatology
Beverly Long, Adam R Schmitt, Amy L Weaver, Michaela McGree, Jamie N Bakkum-Gamez, Jerry Brewer, William A Cliby
OBJECTIVES: To determine surgical and pathologic variables associated with recurrence in extramammary Paget's disease (EMPD). METHODS: Medical records of patients seeking care for EMPD from 1/1992-9/2015 were reviewed. Follow-up was restricted to 5years following primary surgery. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method. Risk factors were evaluated for an association with recurrence and positive margins, respectively, using Cox proportional hazards regression and logistic regression...
September 18, 2017: Gynecologic Oncology
Daniel J Callaghan
BACKGROUND: Mohs micrographic surgery (MMS) is the gold standard for treatment of high-risk skin cancers. There has been an upward trend in the use of this procedure as demonstrated by data from Medicare and the National Ambulatory Medical Care Survey. OBJECTIVE: To assess interest in MMS among members of the general public as measured by number of online searches, and how that interest has changed over time. MATERIALS AND METHODS: Google Trends was used to plot interest in search terms including "Mohs surgery," "basal cell carcinoma," "squamous cell carcinoma," "melanoma," and "skin cancer" from January 1, 2004, to November 30, 2016...
September 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Haitham Abaza, Michael Marschollek
BACKGROUND: With the continuous and enormous spread of mobile technologies, mHealth has evolved as a new subfield of eHealth. While eHealth is broadly focused on information and communication technologies, mHealth seeks to explore more into mobile devices and wireless communication. Since mobile phone penetration has exceeded other infrastructure in low and middle-income countries (LMICs), mHealth is seen as a promising component to provide pervasive and patient-centered care. OBJECTIVES: The aim of our research work for this paper is to examine the mHealth literature to identify application areas, target diseases, and mHealth service and technology types that are most appropriate for LMICs...
August 8, 2017: Methods of Information in Medicine
Peng Mao, Alexander J Brown, Ewa P Malc, Piotr A Mieczkowski, Michael J Smerdon, Steven A Roberts, John J Wyrick
DNA base damage is an important contributor to genome instability, but how the formation and repair of these lesions is affected by the genomic landscape and contributes to mutagenesis is unknown. Here, we describe genome-wide maps of DNA base damage, repair, and mutagenesis at single nucleotide resolution in yeast treated with the alkylating agent methyl methanesulfonate (MMS). Analysis of these maps revealed that base excision repair (BER) of alkylation damage is significantly modulated by chromatin, with faster repair in nucleosome-depleted regions, and slower repair and higher mutation density within strongly positioned nucleosomes...
October 2017: Genome Research
C Camarero-Mulas, Y Delgado Jiménez, O Sanmartín-Jiménez, J R Garcés, M A Rodríguez-Prieto, T Alonso-Alonso, R Miñano Medrano, J L López-Estebaranz, E de Eusebio Murillo, P Redondo, C Ciudad-Blanco, A Toll-Abelló, J L Artola Igarza, I Allende Markixana, R Suarez Fernández, A Alfaro Rubio, M L Alonso Pacheco, H Vázquez-Veiga, P de la Cueva Dobao, V Ruiz-Salas, E Vilarrasa Rull, L Barchino, V Morales-Gordillo, I Ocerin-Guerra, R Navarro Tejedor, L Hueso, M Mayor Arenal, M J Seoane-Pose, N Cano-Martinez, I Garcia-Doval, M A Descalzo
BACKGROUND: The elderly population is increasing and more patients in this group undergo Mohs micrographic surgery. The few publications investigating MMS in elderly people conclude that it is a safe procedure; however, these are single centre studies without a comparison group. OBJECTIVE: To compare the characteristics of patients, tumours, MMS, and one-year follow-up in patients younger than 80 years, with patients older than 80 years at the time of surgery. METHODS: Data was analysed from REGESMOHS, a prospective cohort study of patients treated with MMS...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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