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https://www.readbyqxmd.com/read/28527512/protective-effect-of-capsaicin-against-methyl-methanesulphonate-induced-toxicity-in-the-third-instar-larvae-of-transgenic-drosophila-melanogaster-hsp70-lacz-bg-9
#1
Saba Khanam, Ambreen Fatima, Rahul Smita Jyoti, Fahad Ali, Falaq Naz, Barkha Shakya, Yasir Hasan Siddique
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the main component in hot peppers, including red chili peppers, jalapenos, and habanero, belonging to the genus Capsicum. Capsaicin is a potent antioxidant that interferes with free radical activities. In the present study, the possible protective effect of capsaicin was studied against methyl methanesulphonate (MMS) induced toxicity in third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg(9). The third instar was allowed to feed on the diet having different doses of capsaicin and MMS separately and in combination...
April 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28498188/the-impact-of-structured-mentor-mother-programs-on-presentation-for-early-infant-diagnosis-testing-in-rural-north-central-nigeria-a-prospective-paired-cohort-study
#2
Nadia A Sam-Agudu, Habib O Ramadhani, Christopher Isah, Salome Erekaha, Chinenye Fan-Osuala, Udochisom Anaba, Ebunoluwa A Adejuyigbe, Manhattan Charurat
BACKGROUND: Early infant diagnosis (EID) by 2 months of age is an important prevention of mother-to-child cascade step that serves as an early postpartum indicator of program success. Uptake and timely presentation for infant HIV diagnosis are significant challenges in resource-limited settings. Few studies on maternal peer support (PS) have demonstrated impact on EID. The MoMent study evaluated the impact of structured PS on timely presentation for EID testing in rural North-Central Nigeria...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28498187/the-impact-of-structured-mentor-mother-programs-on-6-month-postpartum-retention-and-viral-suppression-among-hiv-positive-women-in-rural-nigeria-a-prospective-paired-cohort-study
#3
Nadia A Sam-Agudu, Habib O Ramadhani, Christopher Isah, Udochisom Anaba, Salome Erekaha, Chinenye Fan-Osuala, Hadiza Galadanci, Manhattan Charurat
BACKGROUND: Peer support (PS) has reportedly improved Prevention of mother-to-child transmission (PMTCT) outcomes in high HIV-burden settings; however, evidence of impact on retention in care is limited. Retention in care implies consistent engagement and treatment adherence. The MoMent study evaluated the impact of structured vs unstructured PS on postpartum retention and viral load suppression among rural Nigerian women. METHODS: A total of 497 HIV-positive pregnant women were consecutively enrolled at 10 primary health care centers with structured mentor mother (MM) support, and at 10 pair-matched primary health care centers with routine, ad hoc PS...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28492524/sociodemographic-and-attitudinal-predictors-of-simultaneous-and-redundant-multiple-marker-and-cell-free-dna-screening-among-women-aged-%C3%A2-35-years
#4
A K Lewkowitz, A J Kaimal, K Thao, A O'Leary, O Nseyo, M Kuppermann
OBJECTIVE: To identify characteristics associated with undergoing cell-free DNA (cfDNA) and multiple marker screening (MMS) simultaneously or redundantly (after receiving negative results from the first screening test) among women aged ⩾35 years. STUDY DESIGN: Participants presenting for prenatal testing completed a questionnaire that included measures of pregnancy worry and attitudes toward potential testing outcomes; data on prenatal test use was obtained via medical record review...
May 11, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28487616/age-related-impairment-of-esophagogastric-junction-relaxation-and-bolus-flow-time
#5
Charles Cock, Laura K Besanko, Carly M Burgstad, Alison Thompson, Stamatiki Kritas, Richard Heddle, Robert Jl Fraser, Taher I Omari
AIM: To investigate the functional effects of abnormal esophagogastric (EGJ) measurements in asymptomatic healthy volunteers over eighty years of age. METHODS: Data from 30 young controls (11 M, mean age 37 ± 11 years) and 15 aged subjects (9 M, 85 ± 4 years) were compared for novel metrics of EGJ-function: EGJ-contractile integral (EGJ-CI), "total" EGJ-CI and bolus flow time (BFT). Data were acquired using a 3.2 mm, 25 pressure (1 cm spacing) and 12 impedance segment (2 cm) solid-state catheter (Unisensor and MMS Solar GI system) across the EGJ...
April 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28468907/gsk-3%C3%A3-homolog-rim11-and-the-histone-deacetylase-complex-ume6-sin3-rpd3-are-involved-in-replication-stress-response-caused-by-defects-in-dna2
#6
Annie Albert Demin, Miju Lee, Chul-Hwan Lee, Yeon-Soo Seo
Lagging strand synthesis is mechanistically far more complicated than leading strand synthesis, since it involves multi-step processes and requires considerably more enzymes and protein factors. Due to this complexity, multiple fail-safe factors are required to ensure successful replication of the lagging strand DNA. We attempted to identify novel factors that are required in the absence of the helicase activity of Dna2, an essential enzyme in Okazaki fragment maturation. In this paper, we identified Rim11, a GSK-3ß kinase homolog, as a multicopy suppressor of dna2 helicase-dead mutant (dna2-K1080E)...
May 3, 2017: Genetics
https://www.readbyqxmd.com/read/28468371/numerical-study-of-tunable-enhanced-chirality-in-multilayer-stack-achiral-phase-change-metamaterials
#7
Tun Cao, Yang Li, Chen-Wei Wei, Yi-Mei Qiu
We numerically demonstrate a multiband circular dichroism (CD) by tilting achiral metamaterials (MMs) composed of an elliptical nanoholes array (ENA) penetrating through metal/ phase-change material (PCM) /metal multilayer stack, with respect to the incident light. The CD spectrum can be actively tuned across a wide range from the near-infrared (NIR) to mid-infrared (MIR) regime by transiting the state of the PCM (Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>5</sub>) from amorphous to crystalline...
May 1, 2017: Optics Express
https://www.readbyqxmd.com/read/28459552/matched-molecular-series-measuring-sar-similarity
#8
Emanuel S R Ehmki, Christian Kramer
Suggesting novel compounds to be made on the basis of similarity to a previously seen structure-activity relationship (SAR) requires a measure for SAR similarity. While SAR similarity has intuitively been used by medicinal chemists for decades, no systematic comparison of candidate similarity metrics has been published to date. With this publication, we attempt to close that gap by providing a statistical framework that allows comparison of SAR similarity metrics by their ability to rank series that provide the best activity prediction of novel substituents...
May 1, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28459532/synergistic-effects-of-an-irreversible-dna-polymerase-inhibitor-and-dna-damaging-agents-on-hela-cells
#9
Rakesh Paul, Samya Banerjee, Marc M Greenberg
DNA repair is vital to maintaining genome integrity but thwarts the effects of cytotoxic agents that target nucleic acids. Consequently, repair enzymes are potential targets for molecules that modulate cell function and anticancer therapeutics. DNA polymerase β (Pol β) is an attractive target because it plays a key role in base excision repair (BER), a primary pathway that repairs the effects of many DNA damaging agents. We previously identified an irreversible inhibitor of Pol β whose design was based upon a DNA lesion that inactivates Pol β and its back up BER enzyme, DNA polymerase λ (Pol λ)...
May 1, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28458285/development-of-adcs-using-molecular-imaging
#10
Masahiro Yasunaga, Shino Manabe, Atsushi Tsuji, Mamoru Furuta, Koretsugu Ogata, Yoshikatsu Koga, Yuki Fujiwara, Tsuneo Saga, Yasuhiro Matsumura
 Antibody-drug conjugates (ADCs) comprise an antibody, a linker, and a drug or payload. The selection of a tumor-specific antibody and development of a linker having an efficient controlled drug release (CDR) are critical steps in developing a fully functional and effective ADC. In our research strategy, molecular imaging technologies have been employed to evaluate the efficiency of antibody delivery and CDR of the linker. In preclinical setting, antibody delivery into the tumor area or antibody penetration through the tumor stroma in malignant lymphoma or pancreatic tumor was evaluated by in vivo fluorescence imaging technique...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28458162/a-genetic-study-based-on-pcna-ubiquitin-fusions-reveals-no-requirement-for-pcna-polyubiquitylation-in-dna-damage-tolerance
#11
Judit Z Gervai, Judit Gálicza, Zoltán Szeltner, Judit Zámborszky, Dávid Szüts
Post-translational modifications of Proliferating Cell Nuclear Antigen (PCNA) play a key role in regulating the bypass of DNA lesions during DNA replication. PCNA can be monoubiquitylated at lysine 164 by the RAD6-RAD18 ubiquitin ligase complex. Through this modification, PCNA can interact with low fidelity Y family DNA polymerases to promote translesion synthesis. Monoubiquitylated PCNA can be polyubiquitylated on lysine 63 of ubiquitin by a further ubiquitin-conjugating complex. This modification promotes a template switching bypass process in yeast, while its role in higher eukaryotes is less clear...
April 14, 2017: DNA Repair
https://www.readbyqxmd.com/read/28455948/mobile-phone-text-messaging-to-improve-medication-adherence-in-secondary-prevention-of-cardiovascular-disease
#12
REVIEW
Alma J Adler, Nicole Martin, Javier Mariani, Carlos D Tajer, Onikepe O Owolabi, Caroline Free, Norma C Serrano, Juan P Casas, Pablo Perel
BACKGROUND: Worldwide at least 100 million people are thought to have prevalent cardiovascular disease (CVD). This population has a five times greater chance of suffering a recurrent cardiovascular event than people without known CVD. Secondary CVD prevention is defined as action aimed to reduce the probability of recurrence of such events. Drug interventions have been shown to be cost-effective in reducing this risk and are recommended in international guidelines. However, adherence to recommended treatments remains sub-optimal...
April 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28453605/outlier-practice-patterns-in-mohs-micrographic-surgery-defining-the-problem-and-a-proposed-solution
#13
Aravind Krishnan, Tim Xu, Susan Hutfless, Angela Park, Thomas Stasko, Allison T Vidimos, Barry Leshin, Brett M Coldiron, Richard G Bennett, Victor J Marks, Rebecca Brandt, Martin A Makary, John G Albertini
Importance: Outlier physician practices in health care can represent a significant burden to patients and the health system. Objective: To study outlier physician practices in Mohs micrographic surgery (MMS) and the associated factors. Design, Setting, and Participants: This retrospective analysis of publicly available Medicare Part B claims data from January 2012 to December 2014 includes all physicians who received Medicare payments for MMS from any practice performing MMS on the head and neck, genitalia, hands, and feet region of Medicare Part B patients...
April 28, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28445202/adnexal-carcinomas-treated-with-mohs-micrographic-surgery-a-comprehensive-review
#14
Stanislav N Tolkachjov
BACKGROUND: Adnexal carcinomas (ACs) are rare cutaneous malignancies of sweat gland or pilosebaceous origin. Optimal treatment and metastatic potential of AC are poorly defined. Mohs micrographic surgery (MMS) has been increasingly used to treat AC. OBJECTIVE: To review selected primary cutaneous AC and their treatment outcomes with MMS. MATERIALS AND METHODS: Literature review using PubMed search for articles related to primary cutaneous ACs...
April 28, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28434807/claimed-effects-outcome-variables-and-methods-of-measurement-for-health-claims-proposed-under-european-community-regulation-1924-2006-in-the-framework-of-protection-against-oxidative-damage-and-cardiovascular-health
#15
REVIEW
D Martini, S Rossi, B Biasini, I Zavaroni, G Bedogni, M Musci, C Pruneti, G Passeri, M Ventura, S Di Nuzzo, D Galli, P Mirandola, M Vitale, A Dei Cas, R C Bonadonna, D Del Rio
BACKGROUND AND AIMS: The high number of negative opinions from the European Food Safety Authority (EFSA) to the requests for authorization of health claims is largely due to the design of human intervention studies, including the inappropriate choice of outcome variables (OVs) and of their methods of measurement (MMs). The present manuscript reports the results of an investigation aimed to collect, collate and critically analyse the information in relation to claimed effects, OVs and MMs, in the context of protection against oxidative damage and cardiovascular health compliant with Regulation 1924/2006...
February 13, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28432169/primary-malignant-melanoma-of-the-cervix-a-rare-disease
#16
Ivo Julião, Sonia Dias Carvalho, Vanda Patricio, Ana Raimundo
Malignant melanoma (MM) arising primarily in the cervix is exceedingly rare and has a poor prognosis. We report the case of a primary MM of the cervix in a 64-year-old woman with vaginal bleeding. She presented with a cervical amelanotic lesion which on biopsy rendered the diagnosis of MM. The patient was staged as International Federation of Gynecology and Obstetrics IIB and underwent Wertheim-Meigshysterectomy followed by brachytherapy. One year later, she was diagnosed with a large pelvic relapse for which surgery was performed...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28422438/moyamoya-syndrome-in-children-with-neurofibromatosis-type-1-italian-french-experience
#17
Claudia Santoro, Federico Di Rocco, Manoelle Kossorotoff, Michel Zerah, Nathalie Boddaert, Raphael Calmon, Dominique Vidaud, Mario Cirillo, Giuseppe Cinalli, Giuseppe Mirone, Teresa Giugliano, Giulio Piluso, Alessandra D'Amico, Valeria Capra, Marco Pavanello, Armando Cama, Bruno Nobili, Stanislas Lyonnet, Silverio Perrotta
Moyamoya syndrome (MMS) is the most common cerebral vasculopathy among children with neurofibromatosis type 1 (NF1). In this study, we clinically, radiologically, and genetically examined a cohort that was not previously described, comprising European children with NF1 and MMS. The NF1 genotyping had been registered. This study included 18 children. The mean age was 2.93 ± 3.03 years at the NF1 diagnosis and 7.43 ± 4.27 years at the MMS diagnosis. In seven patients, MMS was diagnosed before or at the same time as NF1...
April 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28409813/double-layer-interlaced-nested-multi-ring-array-metallic-mesh-for-high-performance-transparent-electromagnetic-interference-shielding
#18
Heyan Wang, Zhengang Lu, Yeshu Liu, Jiubin Tan, Limin Ma, Shen Lin
We report a nested multi-ring array metallic mesh (NMA-MM) that shows a highly uniform diffraction pattern theoretically and experimentally. Then a high-performance transparent electromagnetic interference (EMI) shielding structure is constituted by the double-layer interlaced NMA-MMs separated by transparent quartz-glass substrate. Experimental results show that double-layer interlaced NMA-MM structure exhibits a shielding effectiveness (SE) of over 27 dB in the Ku-band, with a maximal SE of 37 dB at 12 GHz, normalized optical transmittance of 90%, and minimal image quality degradation due to the interlaced arrangement...
April 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28398256/registration-of-vehicle-borne-point-clouds-and-panoramic-images-based-on-sensor-constellations
#19
Lianbi Yao, Hangbin Wu, Yayun Li, Bin Meng, Jinfei Qian, Chun Liu, Hongchao Fan
A mobile mapping system (MMS) is usually utilized to collect environmental data on and around urban roads. Laser scanners and panoramic cameras are the main sensors of an MMS. This paper presents a new method for the registration of the point clouds and panoramic images based on sensor constellation. After the sensor constellation was analyzed, a feature point, the intersection of the connecting line between the global positioning system (GPS) antenna and the panoramic camera with a horizontal plane, was utilized to separate the point clouds into blocks...
April 11, 2017: Sensors
https://www.readbyqxmd.com/read/28376638/transabdominal-collection-of-amniotic-fluid-sludge-and-identification-of-candida-albicans-intra-amniotic-infection
#20
Juan P Kusanovic, Roberto Romero, Carolina Martinovic, Karla Silva, Offer Erez, Eli Maymon, Francisco Díaz, Fernando Ferrer, Rafael Valdés, Víctor Córdova, Paula Vargas, María Elena Nilo, Patricio Le Cerf
A G3P2 patient who conceived while using an intrauterine contraceptive device (IUD) presented at 20 weeks of gestation with mild irregular uterine contractions and vaginal bleeding. Sonographic examination at admission showed the presence of dense amniotic fluid "sludge" and a long sonographic uterine cervix (42 mm). To assess the microbiologic significance of amniotic fluid "sludge", we performed a transabdominal amniocentesis. The procedure was performed under real-time ultrasound, and fluid resembling pus at gross examination was noted...
May 3, 2017: Journal of Maternal-fetal & Neonatal Medicine
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