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https://www.readbyqxmd.com/read/28823060/cardiac-death-in-patients-with-left-ventricular-aneurysm-remodeling-and-myocardial-viability-by-gated-99m-tc-mibi-spect-and-gated-18-f-fdg-pet
#1
Weixue Wang, Xiang Li, Congna Tian, Shihua Zhao, Marcus Hacker, Xiaoli Zhang
(1) To evaluate the prognostic value of LV remodeling parameters in patients with LV aneurysm by gated SPECT (GSPECT), gated PET (GPET) and CMR; (2) to evaluate the impact of myocardial viability and LV remodeling on the long-term cardiac survival in patients with LV aneurysm. One hundred and twenty-six consecutive patients underwent GPET, GSPECT and CMR within two weeks, with a mean follow-up of 3.9 ± 1.5 years. End-diastolic volume (EDV, mL) and end-systolic volume (ESV, mL) measured by GPET, GSPECT and CMR and corrected for BSA; EDVI and ESVI were calculated...
August 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28806726/replication-fork-slowing-and-stalling-are-distinct-checkpoint-independent-consequences-of-replicating-damaged-dna
#2
Divya Ramalingam Iyer, Nicholas Rhind
In response to DNA damage during S phase, cells slow DNA replication. This slowing is orchestrated by the intra-S checkpoint and involves inhibition of origin firing and reduction of replication fork speed. Slowing of replication allows for tolerance of DNA damage and suppresses genomic instability. Although the mechanisms of origin inhibition by the intra-S checkpoint are understood, major questions remain about how the checkpoint regulates replication forks: Does the checkpoint regulate the rate of fork progression? Does the checkpoint affect all forks, or only those encountering damage? Does the checkpoint facilitate the replication of polymerase-blocking lesions? To address these questions, we have analyzed the checkpoint in the fission yeast Schizosaccharomyces pombe using a single-molecule DNA combing assay, which allows us to unambiguously separate the contribution of origin and fork regulation towards replication slowing, and allows us to investigate the behavior of individual forks...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28802488/characterization-of-surgical-procedures-in-the-spanish-mohs-surgery-registry-regesmohs-for-2013-2015
#3
E de Eusebio Murillo, A Martín Fuentes, V Ruiz-Salas, J R Garcés, R Miñano Medrano, J L López-Estebaranz, T Alonso-Alonso, M Á Rodríguez-Prieto, Y Delgado Jiménez, V Morales, P Redondo Bellón, E Manubens-Mercadé, O Sanmartín-Jiménez, C Guillén Barona, R Cabeza, N Cano, A Toll-Abelló, R Navarro Tejedor, J L Artola Igarza, I Allende Markixana, A Alfaro Rubio, C Ciudad Blanco, H Vázquez-Veiga, L Barchino Ortiz, M A Descalzo, I García-Doval
INTRODUCTION: The Spanish Mohs Surgery Registry is used to collect data on the use and outcomes of Mohs micrographic surgery (MMS) in Spain. The aim of this study was to describe perioperative and intraoperative data recorded for MMS procedures performed between July 2013 (when the registry started) and January 2016. MATERIAL AND METHODS: Prospective cohort study of data from 18 hospitals. The data collected included type of anesthesia, surgical technique, hospital admission, number of Mohs stages, management of preoperative risk factors, additional treatments, previous treatments, type of tumor, operating time, and complications...
August 9, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28795284/dermatofibrosarcoma-protuberans
#4
REVIEW
Alvaro E Acosta, Catalina Santa Vélez
Dermatofibrosarcoma protuberans (DFSP) is a slow growing tumor with a very low metastatic potential but with significant subclinical extension and great capacity for local destruction. Thus, the first surgeon approached with such challenging tumor must attempt to cure the patient with a method that spares healthy tissue and ensures an optimal oncological, functional, and esthetic result. The treatment of DFSP often requires a multidisciplinary approach. Depending on location, dermatologic surgeons, surgical oncologists, head and neck surgeons, neurosurgeons, plastic surgeons, and occasionally medical oncologists may be involved with the management...
August 10, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28783071/structural-engineering-of-metal-mesh-structure-applicable-for-transparent-electrodes-fabricated-by-self-formable-cracked-template
#5
Yeong-Gyu Kim, Young Jun Tak, Sung Pyo Park, Hee Jun Kim, Hyun Jae Kim
Flexible and transparent conducting electrodes are essential for future electronic devices. In this study, we successfully fabricated a highly-interconnected metal-mesh structure (MMS) using a self-formable cracked template. The template-fabricated from colloidal silica-can be easily formed and removed, presenting a simple and cost-effective way to construct a randomly and uniformly networked MMS. The structure of the MMS can be controlled by varying the spin-coating speed during the coating of the template solution or by stacking of metal-mesh layers...
August 5, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28770594/multi-month-prescriptions-fast-track-refills-and-community-art-groups-results-from-a-process-evaluation-in-malawi-on-using-differentiated-models-of-care-to-achieve-national-hiv-treatment-goals
#6
REVIEW
Margaret L Prust, Clement K Banda, Rose Nyirenda, Frank Chimbwandira, Thokozani Kalua, Andreas Jahn, Michael Eliya, Katie Callahan, Peter Ehrenkranz, Marta R Prescott, Elizabeth A McCarthy, Elya Tagar, Andrews Gunda
INTRODUCTION: In order to facilitate scale-up of antiretroviral therapy (ART) in Malawi, innovative and pragmatic models have been developed to optimize the efficiency of HIV service delivery. In particular, three models of differentiated care have emerged for stable patients: adjusted appointment spacing through multi-month scripting (MMS); fast-track drug refills (FTRs) on alternating visits; and community ART groups (CAGs) where group members rotate in collecting medications at the facility for all members...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28749422/metamaterials-and-metasurfaces-for-sensor-applications
#7
REVIEW
Yohan Lee, Sun-Je Kim, Hyeonsoo Park, Byoungho Lee
Electromagnetic metamaterials (MMs) and metasurfaces (MSs) are artificial media and surfaces with subwavelength separations of meta-atoms designed for anomalous manipulations of light properties. Owing to large scattering cross-sections of metallic/dielectric meta-atoms, it is possible to not only localize strong electromagnetic fields in deep subwavelength volume but also decompose and analyze incident light signal with ultracompact setup using MMs and MSs. Hence, by probing resonant spectral responses from extremely boosted interactions between analyte layer and optical MMs or MSs, sensing the variation of refractive index has been a popular and practical application in the field of photonics...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28742794/the-cost-effectiveness-of-screening-for-ovarian-cancer-results-from-the-uk-collaborative-trial-of-ovarian-cancer-screening-ukctocs
#8
Usha Menon, Alistair J McGuire, Maria Raikou, Andy Ryan, Susan K Davies, Matthew Burnell, Aleksandra Gentry-Maharaj, Jatinderpal K Kalsi, Naveena Singh, Nazar N Amso, Derek Cruickshank, Stephen Dobbs, Keith Godfrey, Jonathan Herod, Simon Leeson, Tim Mould, John Murdoch, David Oram, Ian Scott, Mourad W Seif, Karin Williamson, Robert Woolas, Lesley Fallowfield, Stuart Campbell, Steven J Skates, Mahesh Parmar, Ian J Jacobs
BACKGROUND: To assess the within-trial cost-effectiveness of an NHS ovarian cancer screening (OCS) programme using data from UKCTOCS and extrapolate results based on average life expectancy. METHODS: Within-trial economic evaluation of no screening (C) vs either (1) an annual OCS programme using transvaginal ultrasound (USS) or (2) an annual ovarian cancer multimodal screening programme with serum CA125 interpreted using a risk algorithm (ROCA) and transvaginal ultrasound as a second-line test (MMS), plus comparison of lifetime extrapolation of the no screening arm and the MMS programme using both a predictive and a Markov model...
July 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28732331/an-evaluation-of-dna-damage-in-human-lymphocytes-and-sperm-exposed-to-methyl-methanesulfonate-involving-the-regulation-pathways-associated-with-apoptosis
#9
Khaled Habas, Mojgan Najafzadeh, Adolf Baumgartner, Martin H Brinkworth, Diana Anderson
Exposure to DNA-damaging agents produces a range of stress-related responses. These change the expression of genes leading to mutations that cause cell cycle arrest, induction of apoptosis and cancer. We have examined the contribution of haploid and diploid DNA damage and genes involved in the regulation of the apoptotic process associated with exposure, The Comet assay was used to detect DNA damage and quantitative RT-PCR analysis (qPCR) to detect gene expression changes in lymphocytes and sperm in response to methyl methanesulfonate...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28728328/reconstruction-of-large-facial-defects-via-excision-of-skin-cancer-using-two-or-more-regional-flaps
#10
Dong Min Lee, Yong Chan Bae, Su Bong Nam, Seong Hwan Bae, June Seok Choi
BACKGROUND: Free-flap surgery and skin grafting can be used to reconstruct large facial defects that may result after skin cancer removal by Mohs micrographic surgery (MMS). However, these two methods may produce low postsurgical patient satisfaction with aesthetics, and free-flap surgery may produce an undue burden for the majority of skin cancer patients, who are of advanced age. Hence, the authors examined outcomes of large facial defect reconstruction using multiple flaps. METHODS: Among patients undergoing MMS for skin cancer at Pusan National University Hospital between January 2013 and December 2015, we evaluated 7 patients (2 males, 5 females; average age, 73...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28726787/alkbh7-drives-a-tissue-and-sex-specific-necrotic-cell-death-response-following-alkylation-induced-damage
#11
Jennifer J Jordan, Sophea Chhim, Carrie M Margulies, Mariacarmela Allocca, Roderick T Bronson, Arne Klungland, Leona D Samson, Dragony Fu
Regulated necrosis has emerged as a major cell death mechanism in response to different forms of physiological and pharmacological stress. The AlkB homolog 7 (ALKBH7) protein is required for regulated cellular necrosis in response to chemotherapeutic alkylating agents but its role within a whole organism is unknown. Here, we show that ALKBH7 modulates alkylation-induced cellular death through a tissue and sex-specific mechanism. At the whole-animal level, we find that ALKBH7 deficiency confers increased resistance to MMS-induced toxicity in male but not female mice...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28713180/global-observations-of-magnetospheric-high-m-poloidal-waves-during-the-22-june-2015-magnetic-storm
#12
G Le, P J Chi, R J Strangeway, C T Russell, J A Slavin, K Takahashi, H J Singer, B J Anderson, K Bromund, D Fischer, E L Kepko, W Magnes, R Nakamura, F Plaschke, R B Torbert
We report global observations of high-m poloidal waves during the recovery phase of the 22 June 2015 magnetic storm from a constellation of widely spaced satellites of five missions including Magnetospheric Multiscale (MMS), Van Allen Probes, Time History of Events and Macroscale Interactions during Substorm (THEMIS), Cluster, and Geostationary Operational Environmental Satellites (GOES). The combined observations demonstrate the global spatial extent of storm time poloidal waves. MMS observations confirm high azimuthal wave numbers (m ~ 100)...
April 28, 2017: Geophysical Research Letters
https://www.readbyqxmd.com/read/28710767/rapid-detection-of-%C3%AE-h2av-foci-in-ex-vivo-mms-treated-drosophila-imaginal-discs
#13
Varandt Y Khodaverdian, Mitch McVey
In Drosophila melanogaster, DNA double-strand breaks (DSBs) created by exposure to gamma or X-ray radiation can be quantified by immunofluorescent detection of phosphorylated histone H2Av (γ-H2Av) foci in imaginal disc tissues. This technique has been less useful for studying DSBs in imaginal discs exposed to DSB-inducing chemicals, since standard protocols require raising larvae in food treated with liquid chemical suspensions. These protocols typically take 3-4 days to complete and result in heterogeneous responses that do not provide information about the kinetics of DSB formation and repair...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28709797/smoldering-multiple-myeloma-who-and-when-to-treat
#14
REVIEW
María-Victoria Mateos, Verónica González-Calle
Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder characterized by the presence of ≥ 3 g/dL serum M-protein and/or 10% to 60% bone marrow plasma cell infiltration with no myeloma-defining event. The risk of progression to active multiple myeloma (MM) is not uniform, and several markers are useful for identifying patients at high risk of progression. The definition of the disease has recently been revisited and asymptomatic MMs at 80% to 90% of progression risk at 2 years are now considered to be active MM candidates for treatment...
June 23, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28707935/multipoint-measurements-of-the-electron-jet-of-symmetric-magnetic-reconnection-with-a-moderate-guide-field
#15
F D Wilder, R E Ergun, S Eriksson, T D Phan, J L Burch, N Ahmadi, K A Goodrich, D L Newman, K J Trattner, R B Torbert, B L Giles, R J Strangeway, W Magnes, P-A Lindqvist, Yu-V Khotyaintsev
We report observations from the Magnetospheric Multiscale (MMS) satellites of the electron jet in a symmetric magnetic reconnection event with moderate guide field. All four spacecraft sampled the ion diffusion region and observed the electron exhaust. The observations suggest that the presence of the guide field leads to an asymmetric Hall field, which results in an electron jet skewed towards the separatrix with a nonzero component along the magnetic field. The jet appears in conjunction with a spatially and temporally persistent parallel electric field ranging from -3 to -5  mV/m, which led to dissipation on the order of 8  nW/m^{3}...
June 30, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28705680/characterization-of-significant-molecular-determinants-of-virulence-of-enterovirus-71-sub-genotype-b4-in-rhabdomyosarcoma-cells
#16
Pinn Tsin Isabel Yee, Reham Ahmed Hashim Mohamed, Seng-Kai Ong, Kuan Onn Tan, Chit Laa Poh
One of the leading causes of the hand, foot and mouth disease (HFMD) is Enterovirus 71 (EV-A71), displaying symptoms such as fever and ulcers in children but some strains can produce cardiopulmonary oedema which leads to death. There is no FDA-approved vaccine for prevention of severe HFMD. The molecular determinants of virulence for EV-A71 are unclear. It could be a single or a combination of amino acids that determines virulence in different EV-A71 genotype/sub-genotypes. Several EV-A71 strains bearing single nucleotide (nt) mutations were constructed and the contribution of each mutation to virulence was evaluated...
July 10, 2017: Virus Research
https://www.readbyqxmd.com/read/28704876/mesenteric-masses-on-2d-mode-and-contrast-enhanced-ultrasound-a-retrospective-study-in-69-patients
#17
Corinna Trenker, Ehsan Safaei Zadeh, Golo Petzold, Christian Görg, Albrecht Neesse
Purpose Detection of mesenteric masses (MM) by 2 D ultrasound often causes a diagnostic dilemma, and histological confirmation is required for definite diagnosis. The value of contrast-enhanced ultrasound (CEUS) for the diagnosis of MMs has not been investigated before. Here, we retrospectively evaluate 2D-mode and CEUS patterns of 69 patients with histologically confirmed MMs. Materials and Methods Between January 2006 and January 2016, n = 69 patients were included in the study. Histopathological data, clinical data, 2D-mode ultrasound and CEUS enhancement were retrospectively analyzed...
July 13, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28691197/loss-of-dcc-in-the-spinal-cord-is-sufficient-to-cause-a-deficit-in-lateralized-motor-control-and-the-switch-to-a-hopping-gait
#18
Jimmy Peng, Julien Ferent, Qingyu Li, Mingwei Liu, Ronan Vinicius da Silva, Hanns Ulrich Zeilhofer, Artur Kania, Ying Zhang, Frédéric Charron
BACKGROUND: Humans with heterozygous mutations in the axon guidance receptor DCC display congenital mirror movements (MMs), which are involuntary movements of body parts, such as fingers, on one side of the body that mirror voluntary movement of the opposite side. In mice, the homozygous Dcc(kanga) mutant allele causes synchronous MM-like hindlimb movements during locomotion, resulting in hopping. In both human and mice, the neuroanatomical defect responsible for the deficit in lateralized motor control remains to be elucidated...
July 10, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28690927/quantitative-proteome-level-analysis-of-paulownia-witches-broom-disease-with-methyl-methane-sulfonate-assistance-reveals-diverse-metabolic-changes-during-the-infection-and-recovery-processes
#19
Zhe Wang, Wenshan Liu, Guoqiang Fan, Xiaoqiao Zhai, Zhenli Zhao, Yanpeng Dong, Minjie Deng, Yabing Cao
Paulownia witches' broom (PaWB) disease caused by phytoplasma is a fatal disease that leads to considerable economic losses. Although there are a few reports describing studies of PaWB pathogenesis, the molecular mechanisms underlying phytoplasma pathogenicity in Paulownia trees remain uncharacterized. In this study, after building a transcriptome database containing 67,177 sequences, we used isobaric tags for relative and absolute quantification (iTRAQ) to quantify and analyze the proteome-level changes among healthy P...
2017: PeerJ
https://www.readbyqxmd.com/read/28688069/shoreline-change-assessment-using-multi-temporal-satellite-images-a-case-study-of-lake-sapanca-nw-turkey
#20
Umit Duru
The research summarized here determines historical shoreline changes along Lake Sapanca by using Remote Sensing (RS) and Geographical Information Systems (GIS). Six multi-temporal satellite images of Landsat Multispectral Scanner (L1-5 MMS), Enhanced Thematic Mapper Plus (L7 ETM+), and Operational Land Imager Sensors (L8 OLI), covering the period between 17 June 1975 and 15 July 2016, were used to monitor shoreline positions and estimate change rates along the coastal zone. After pre-possessing routines, the Normalized Difference Water Index (NDWI), Modified Normalized Difference Water Index (MNDWI), and supervised classification techniques were utilized to extract six different shorelines...
August 2017: Environmental Monitoring and Assessment
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