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https://www.readbyqxmd.com/read/28732331/an-evaluation-of-dna-damage-in-human-lymphocytes-and-sperm-exposed-to-methyl-methanesulfonate-involving-the-regulation-pathways-associated-with-apoptosis
#1
Khaled Habas, Mojgan Najafzadeh, Adolf Baumgartner, Martin H Brinkworth, Diana Anderson
Exposure to DNA-damaging agents produces a range of stress-related responses. These change the expression of genes leading to mutations that cause cell cycle arrest, induction of apoptosis and cancer. We have examined the contribution of haploid and diploid DNA damage and genes involved in the regulation of the apoptotic process associated with exposure, The Comet assay was used to detect DNA damage and quantitative RT-PCR analysis (qPCR) to detect gene expression changes in lymphocytes and sperm in response to methyl methanesulfonate...
June 23, 2017: Chemosphere
https://www.readbyqxmd.com/read/28728328/reconstruction-of-large-facial-defects-via-excision-of-skin-cancer-using-two-or-more-regional-flaps
#2
Dong Min Lee, Yong Chan Bae, Su Bong Nam, Seong Hwan Bae, June Seok Choi
BACKGROUND: Free-flap surgery and skin grafting can be used to reconstruct large facial defects that may result after skin cancer removal by Mohs micrographic surgery (MMS). However, these two methods may produce low postsurgical patient satisfaction with aesthetics, and free-flap surgery may produce an undue burden for the majority of skin cancer patients, who are of advanced age. Hence, the authors examined outcomes of large facial defect reconstruction using multiple flaps. METHODS: Among patients undergoing MMS for skin cancer at Pusan National University Hospital between January 2013 and December 2015, we evaluated 7 patients (2 males, 5 females; average age, 73...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28726787/alkbh7-drives-a-tissue-and-sex-specific-necrotic-cell-death-response-following-alkylation-induced-damage
#3
Jennifer J Jordan, Sophea Chhim, Carrie M Margulies, Mariacarmela Allocca, Roderick T Bronson, Arne Klungland, Leona D Samson, Dragony Fu
Regulated necrosis has emerged as a major cell death mechanism in response to different forms of physiological and pharmacological stress. The AlkB homolog 7 (ALKBH7) protein is required for regulated cellular necrosis in response to chemotherapeutic alkylating agents but its role within a whole organism is unknown. Here, we show that ALKBH7 modulates alkylation-induced cellular death through a tissue and sex-specific mechanism. At the whole-animal level, we find that ALKBH7 deficiency confers increased resistance to MMS-induced toxicity in male but not female mice...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28713180/global-observations-of-magnetospheric-high-m-poloidal-waves-during-the-22-june-2015-magnetic-storm
#4
G Le, P J Chi, R J Strangeway, C T Russell, J A Slavin, K Takahashi, H J Singer, B J Anderson, K Bromund, D Fischer, E L Kepko, W Magnes, R Nakamura, F Plaschke, R B Torbert
We report global observations of high-m poloidal waves during the recovery phase of the 22 June 2015 magnetic storm from a constellation of widely spaced satellites of five missions including Magnetospheric Multiscale (MMS), Van Allen Probes, Time History of Events and Macroscale Interactions during Substorm (THEMIS), Cluster, and Geostationary Operational Environmental Satellites (GOES). The combined observations demonstrate the global spatial extent of storm time poloidal waves. MMS observations confirm high azimuthal wave numbers (m ~ 100)...
April 28, 2017: Geophysical Research Letters
https://www.readbyqxmd.com/read/28710767/rapid-detection-of-%C3%AE-h2av-foci-in-ex-vivo-mms-treated-drosophila-imaginal-discs
#5
Varandt Y Khodaverdian, Mitch McVey
In Drosophila melanogaster, DNA double-strand breaks (DSBs) created by exposure to gamma or X-ray radiation can be quantified by immunofluorescent detection of phosphorylated histone H2Av (γ-H2Av) foci in imaginal disc tissues. This technique has been less useful for studying DSBs in imaginal discs exposed to DSB-inducing chemicals, since standard protocols require raising larvae in food treated with liquid chemical suspensions. These protocols typically take 3-4 days to complete and result in heterogeneous responses that do not provide information about the kinetics of DSB formation and repair...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28709797/smoldering-multiple-myeloma-who-and-when-to-treat
#6
REVIEW
María-Victoria Mateos, Verónica González-Calle
Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder characterized by the presence of ≥ 3 g/dL serum M-protein and/or 10% to 60% bone marrow plasma cell infiltration with no myeloma-defining event. The risk of progression to active multiple myeloma (MM) is not uniform, and several markers are useful for identifying patients at high risk of progression. The definition of the disease has recently been revisited and asymptomatic MMs at 80% to 90% of progression risk at 2 years are now considered to be active MM candidates for treatment...
June 23, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28707935/multipoint-measurements-of-the-electron-jet-of-symmetric-magnetic-reconnection-with-a-moderate-guide-field
#7
F D Wilder, R E Ergun, S Eriksson, T D Phan, J L Burch, N Ahmadi, K A Goodrich, D L Newman, K J Trattner, R B Torbert, B L Giles, R J Strangeway, W Magnes, P-A Lindqvist, Yu-V Khotyaintsev
We report observations from the Magnetospheric Multiscale (MMS) satellites of the electron jet in a symmetric magnetic reconnection event with moderate guide field. All four spacecraft sampled the ion diffusion region and observed the electron exhaust. The observations suggest that the presence of the guide field leads to an asymmetric Hall field, which results in an electron jet skewed towards the separatrix with a nonzero component along the magnetic field. The jet appears in conjunction with a spatially and temporally persistent parallel electric field ranging from -3 to -5  mV/m, which led to dissipation on the order of 8  nW/m^{3}...
June 30, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28705680/characterization-of-significant-molecular-determinants-of-virulence-of-enterovirus-71-sub-genotype-b4-in-rhabdomyosarcoma-cells
#8
Pinn Tsin Isabel Yee, Reham Ahmed Hashim Mohamed, Seng-Kai Ong, Kuan Onn Tan, Chit Laa Poh
One of the leading causes of the hand, foot and mouth disease (HFMD) is Enterovirus 71 (EV-A71), displaying symptoms such as fever and ulcers in children but some strains can produce cardiopulmonary oedema which leads to death. There is no FDA-approved vaccine for prevention of severe HFMD. The molecular determinants of virulence for EV-A71 are unclear. It could be a single or a combination of amino acids that determines virulence in different EV-A71 genotype/sub-genotypes. Several EV-A71 strains bearing single nucleotide (nt) mutations were constructed and the contribution of each mutation to virulence was evaluated...
July 10, 2017: Virus Research
https://www.readbyqxmd.com/read/28704876/mesenteric-masses-on-2d-mode-and-contrast-enhanced-ultrasound-a-retrospective-study-in-69-patients
#9
Corinna Trenker, Ehsan Safaei Zadeh, Golo Petzold, Christian Görg, Albrecht Neesse
Purpose Detection of mesenteric masses (MM) by 2 D ultrasound often causes a diagnostic dilemma, and histological confirmation is required for definite diagnosis. The value of contrast-enhanced ultrasound (CEUS) for the diagnosis of MMs has not been investigated before. Here, we retrospectively evaluate 2D-mode and CEUS patterns of 69 patients with histologically confirmed MMs. Materials and Methods Between January 2006 and January 2016, n = 69 patients were included in the study. Histopathological data, clinical data, 2D-mode ultrasound and CEUS enhancement were retrospectively analyzed...
July 13, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28691197/loss-of-dcc-in-the-spinal-cord-is-sufficient-to-cause-a-deficit-in-lateralized-motor-control-and-the-switch-to-a-hopping-gait
#10
Jimmy Peng, Julien Ferent, Qingyu Li, Mingwei Liu, Ronan Vinicius da Silva, Hanns Ulrich Zeilhofer, Artur Kania, Ying Zhang, Frédéric Charron
BACKGROUND: Humans with heterozygous mutations in the axon guidance receptor DCC display congenital mirror movements (MMs), which are involuntary movements of body parts, such as fingers, on one side of the body that mirror voluntary movement of the opposite side. In mice, the homozygous Dcc(kanga) mutant allele causes synchronous MM-like hindlimb movements during locomotion, resulting in hopping. In both human and mice, the neuroanatomical defect responsible for the deficit in lateralized motor control remains to be elucidated...
July 10, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28690927/quantitative-proteome-level-analysis-of-paulownia-witches-broom-disease-with-methyl-methane-sulfonate-assistance-reveals-diverse-metabolic-changes-during-the-infection-and-recovery-processes
#11
Zhe Wang, Wenshan Liu, Guoqiang Fan, Xiaoqiao Zhai, Zhenli Zhao, Yanpeng Dong, Minjie Deng, Yabing Cao
Paulownia witches' broom (PaWB) disease caused by phytoplasma is a fatal disease that leads to considerable economic losses. Although there are a few reports describing studies of PaWB pathogenesis, the molecular mechanisms underlying phytoplasma pathogenicity in Paulownia trees remain uncharacterized. In this study, after building a transcriptome database containing 67,177 sequences, we used isobaric tags for relative and absolute quantification (iTRAQ) to quantify and analyze the proteome-level changes among healthy P...
2017: PeerJ
https://www.readbyqxmd.com/read/28688069/shoreline-change-assessment-using-multi-temporal-satellite-images-a-case-study-of-lake-sapanca-nw-turkey
#12
Umit Duru
The research summarized here determines historical shoreline changes along Lake Sapanca by using Remote Sensing (RS) and Geographical Information Systems (GIS). Six multi-temporal satellite images of Landsat Multispectral Scanner (L1-5 MMS), Enhanced Thematic Mapper Plus (L7 ETM+), and Operational Land Imager Sensors (L8 OLI), covering the period between 17 June 1975 and 15 July 2016, were used to monitor shoreline positions and estimate change rates along the coastal zone. After pre-possessing routines, the Normalized Difference Water Index (NDWI), Modified Normalized Difference Water Index (MNDWI), and supervised classification techniques were utilized to extract six different shorelines...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28686127/effectiveness-of-surgical-revascularization-for-stroke-prevention-in-pediatric-patients-with-sickle-cell-disease-and-moyamoya-syndrome
#13
Wuyang Yang, Risheng Xu, Jose L Porras, Clifford M Takemoto, Syed Khalid, Tomas Garzon-Muvdi, Justin M Caplan, Geoffrey P Colby, Alexander L Coon, Rafael J Tamargo, Judy Huang, Edward S Ahn
OBJECTIVE Sickle cell disease (SCD) in combination with moyamoya syndrome (MMS) represents a rare complication of SCD, with potentially devastating neurological outcomes. The effectiveness of surgical revascularization in this patient population is currently unclear. The authors' aim was to determine the effectiveness of surgical intervention in their series of SCD-MMS patients by comparing stroke recurrence in those undergoing revascularization and those undergoing conservative transfusion therapy. METHODS The authors performed a retrospective chart review of patients with MMS who were seen at the Johns Hopkins Medical Institution between 1990 and 2013...
July 7, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28685785/identification-of-human-flap-endonuclease-1-fen1-inhibitors-using-a-machine-learning-based-consensus-virtual-screening
#14
Amit Laxmikant Deshmukh, Sharat Chandra, Deependra Kumar Singh, Mohammad Imran Siddiqi, Dibyendu Banerjee
Human Flap endonuclease1 (FEN1) is an enzyme that is indispensable for DNA replication and repair processes and inhibition of its Flap cleavage activity results in increased cellular sensitivity to DNA damaging agents (cisplatin, temozolomide, MMS, etc.), with the potential to improve cancer prognosis. Reports of the high expression levels of FEN1 in several cancer cells support the idea that FEN1 inhibitors may target cancer cells with minimum side effects to normal cells. In this study, we used large publicly available, high-throughput screening data of small molecule compounds targeted against FEN1...
July 7, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28685596/amelanotic-lentigo-maligna-melanoma-mohs-surgery-as-the-definitive-treatment-of-an-invisible-tumour
#15
Marisa Grace Ponzo, Richard Ian Crawford, Irèn Kossintseva
Amelanotic lentigo maligna melanoma represents <2% of melanomas. Diagnosis is delayed owing to the lack of lesion pigmentation and advanced disease at presentation. Excision with appropriate margins is the treatment standard, but the starting point for such margins is often unclear. We describe 2 patients with amelanotic melanoma treated by Mohs micrographic surgery (MMS) that would not have been cleared by wide local excision alone and provide an extensive review of the literature. Both patients presented with histologic diagnoses of malignant melanoma, one with a barely perceptible biopsy site scar on the left infraorbital cheek/lower eyelid (Breslow 1...
July 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28661992/treatment-patterns-outcomes-and-patient-satisfaction-of-primary-epidermally-limited-nonmelanoma-skin-cancer
#16
Benjamin A Drew, Pritesh S Karia, Ariana N Mora, Christine A Liang, Chrysalyne D Schmults
BACKGROUND: Epidermally limited nonmelanoma skin cancer (ELNMSC) (superficial basal cell carcinoma [SBCC] and squamous cell carcinoma in situ [SCCIS]) is common. Data on outcomes and patient satisfaction are lacking. OBJECTIVE: To examine treatment efficacy and satisfaction in ELNMSC patients. PATIENTS AND METHODS: Retrospective cohort study of adults with primary SBCC or SCCIS. A 25% random subset completed a satisfaction questionnaire. RESULTS: Five hundred and fifty patients with 227 SBCC and 451 SCCIS were included; 329 tumors (49%) were treated with Mohs micrographic surgery (MMS) and 349 (51%) with non-MMS (imiquimod [n = 26], 5% 5-fluorouracil [n = 234], ingenol mebutate [n = 32], or cryotherapy [n = 57])...
June 28, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28658881/cross-sectional-observational-study-performed-to-see-for-relation-of-mallampati-score-and-extended-mallampati-score-with-body-mass-index
#17
Sasha Maria Menon, Shailaja Sampangiramaiah, Megha Mathew
INTRODUCTION: There is increasing incidence of obesity worldwide. Since obese patients have an increased fatty tissue distributed in a truncal fashion, they may have an important and negative impact on the airway patency and respiratory function. Various scoring systems have been used to predict difficult airway, the most commonly used universal bedside tool is the Modified Mallampati Scoring (MMS). It was shown that the Extended Mallampati Score (EMS) predicted difficult laryngoscopy better than the MMS in the obese populations...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28654580/mohs-mapping-fidelity-optimizing-orientation-accuracy-and-tissue-identification-in-mohs-surgery
#18
Janet Y Li, Sirunya Silapunt, Michael R Migden, Jamie L McGinness, Tri H Nguyen
BACKGROUND: Mohs micrographic surgery (MMS) is a highly effective process that requires consistent accuracy in resection, mapping, and histologic interpretation. Although the general sequence in MMS is similar, there are numerous variations among Mohs surgeons as to how this process is performed. OBJECTIVE: This article aims to review the process of MMS, with the intent to identify and mitigate the potential errors at each step. Existing variations will be discussed and protocols offered to minimize error and optimize accuracy...
June 23, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28654579/detection-of-high-risk-histologic-features-and-tumor-upstaging-of-nonmelanoma-skin-cancers-on-debulk-analysis-a-quantitative-systematic-review
#19
Babu Singh, Adriana Dorelles, Nellie Konnikov, Bichchau M Nguyen
BACKGROUND: Histologic analysis of tumor debulks from Mohs micrographic surgery (MMS) or wide local excision may lead to the detection of adverse features missed on initial biopsy. OBJECTIVE: Determine the incidence of (1) high-risk features on debulk analysis compared with initial biopsy and (2) upstaging of tumors on debulk analysis according to the American Joint Committee of Cancer-7th Edition (AJCC-7) and the Brigham and Women's Alternative (BWH) staging criteria...
June 28, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28643447/simultaneous-mapping-of-metabolites-and-individual-macromolecular-components-via-ultra-short-acquisition-delay-1-h-mrsi-in-the-brain-at-7t
#20
Michal Považan, Bernhard Strasser, Gilbert Hangel, Eva Heckova, Stephan Gruber, Siegfried Trattnig, Wolfgang Bogner
PURPOSE: Short-echo-time proton MR spectra at 7T feature nine to 10 distinct macromolecule (MM) resonances that overlap with the signals of metabolites. Typically, a metabolite-nulled in vivo MM spectrum is included in the quantification`s prior knowledge to provide unbiased metabolite quantification. However, this MM model may fail if MMs are pathologically altered. In addition, information about the individual MM peaks is lost. In this study, we aimed to create an improved MM model by parameterization of the in vivo MM spectrum into individual components, and to use this new model to quantify free induction decay MR spectroscopic imaging (FID-MRSI) data...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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