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https://www.readbyqxmd.com/read/27919292/cost-effectiveness-of-screening-for-ovarian-cancer-amongst-postmenopausal-women-a-model-based-economic-evaluation
#1
Ben Kearns, Jim Chilcott, Sophie Whyte, Louise Preston, Susi Sadler
BACKGROUND: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) was the biggest ovarian cancer screening trial to date. A non-significant effect of screening on ovarian cancer was reported, but the authors noted a potential delayed effect of screening, and suggested the need for four years further follow-up. There are no UK-based cost-effectiveness analyses of ovarian cancer screening. Hence we assessed the lifetime outcomes associated with, and the cost-effectiveness of, screening for ovarian cancer in the UK, along with the value of further research...
December 6, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27914526/jiawei-erzhiwan-improves-menopausal-metabolic-syndrome-by-enhancing-insulin-secretion-in-pancreatic-%C3%AE-cells
#2
Xiao-Meng Wan, Mu Zhang, Pei Zhang, Zhi-Shen Xie, Feng-Guo Xu, Ping Zhou, Shi-Ping Ma, Xiao-Jun Xu
Menopausal metabolic syndrome (MMS) is a series of syndrome caused by ovarian function decline and hormone insufficiency, and is a high risk factor for cardiovascular diseases (CVD) and type II diabetes mellitus (T2DM). Erzhiwan (EZW), composed of Herba Ecliptae and Fructus Ligustri Lucidi, is a traditional Chinese herbal formula that has been used to treat menopausal syndrome for many years. We added Herba Epimedii, Radix Rehmanniae, and Fructus Corni into EZW, to prepare a new formula, termed Jiawei Erzhiwan (JE)...
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27894265/long-term-condition-morbidity-in-english-general-practice-a-cross-sectional-study-using-three-composite-morbidity-measures
#3
Charlotte Weston, Alexander Gilkes, Stevo Durbaba, Peter Schofield, Patrick White, Mark Ashworth
BACKGROUND: The burden of morbidity represented by patients with long term conditions (LTCs) varies substantially between general practices. This study aimed to determine the characteristics of general practices with high morbidity burden. METHOD: Retrospective cross-sectional study; general practices in England, 2014/15. Three composite morbidity measures (MMs) were constructed to quantify LTC morbidity at practice level: a count of LTCs derived from the 20 LTCs included in the UK Quality and Outcomes Framework (QOF) disease registers, expressed as 'number of QOF LTCs per 100 registered patients'; the % of patients with one or more QOF LTCs; the % of patients with one or more of 15 broadly defined LTCs included in the GP Patient Survey (GPPS)...
November 29, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27877873/preparation-of-magnetic-mesoporous-silica-nanoparticles-as-a-multifunctional-platform-for-potential-drug-delivery-and-hyperthermia
#4
Xia Yu, Yufang Zhu
We report the preparation of magnetic mesoporous silica (MMS) nanoparticles with the potential multifunctionality of drug delivery and magnetic hyperthermia. Carbon-encapsulated magnetic colloidal nanoparticles (MCN@C) were used to coat mesoporous silica shells for the formation of the core-shell structured MMS nanoparticles (MCN@C/mSiO2), and the rattle-type structured MMS nanoparticles (MCN/mSiO2) were obtained after the removal of the carbon layers from MCN@C/mSiO2 nanoparticles. The morphology, structure, magnetic hyperthermia ability, drug release behavior, in vitro cytotoxicity and cellular uptake of MMS nanoparticles were investigated...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27876659/surgical-treatment-for-patients-with-moyamoya-syndrome-and-type-1-neurofibromatosis
#5
Jose L Porras, Wuyang Yang, Tomas Garzon-Muvdi, Risheng Xu, Jaishri Blakeley, Allan Belzberg, Justin M Caplan, Syed Khalid, Geoffrey P Colby, Alexander L Coon, Rafael J Tamargo, Edward S Ahn, Judy Huang
INTRODUCTION: The current study describes the impact of surgery in preventing follow-up ipsilateral TIAs/strokes in an East Coast North American cohort of patients with both moyamoya syndrome (MMS) and neurofibromatosis type 1 (NF1) (MMS-NF1). METHODS: We retrospectively reviewed records of patients with MMS and NF1 at the Johns Hopkins Medical Institutions from 1990-2014. Baseline characteristics and follow-up results including subsequent ipsilateral strokes were collected, and compared between a revascularization group (group1) and a conservatively managed group (group2) on a per-hemisphere basis...
November 19, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27867235/transient-small-scale-field-aligned-currents-in-the-plasma-sheet-boundary-layer-during-storm-time-substorms
#6
R Nakamura, V A Sergeev, W Baumjohann, F Plaschke, W Magnes, D Fischer, A Varsani, D Schmid, T K M Nakamura, C T Russell, R J Strangeway, H K Leinweber, G Le, K R Bromund, C J Pollock, B L Giles, J C Dorelli, D J Gershman, W Paterson, L A Avanov, S A Fuselier, K Genestreti, J L Burch, R B Torbert, M Chutter, M R Argall, B J Anderson, P-A Lindqvist, G T Marklund, Y V Khotyaintsev, B H Mauk, I J Cohen, D N Baker, A N Jaynes, R E Ergun, H J Singer, J A Slavin, E L Kepko, T E Moore, B Lavraud, V Coffey, Y Saito
We report on field-aligned current observations by the four Magnetospheric Multiscale (MMS) spacecraft near the plasma sheet boundary layer (PSBL) during two major substorms on 23 June 2015. Small-scale field-aligned currents were found embedded in fluctuating PSBL flux tubes near the separatrix region. We resolve, for the first time, short-lived earthward (downward) intense field-aligned current sheets with thicknesses of a few tens of kilometers, which are well below the ion scale, on flux tubes moving equatorward/earthward during outward plasma sheet expansion...
May 28, 2016: Geophysical Research Letters
https://www.readbyqxmd.com/read/27853035/dystonia-myoclonus-and-encephalopathy-in-a-single-patient-a-rare-association-of-moyamoya
#7
Ujjawal Roy, Urmila Das, Ajay Panwar, Prabhat Kumar Lal
Moyamoya disease (MMD) is a rare neurovascular disorder which pathologically, is a chronic cerebrovasculopathy. It is characterized by stenosis of the internal carotid artery (ICA) and the main branches within the circle of Willis with consecutive development of collateral vessels. There are a few cases in the literature which have described movement disorders as a manifestation of MMD; however these have been uncommonly reported in cases of moyamoya syndrome (MMS). We present a 10-year-old boy with dystonia, myoclonus and encephalopathy like features...
October 2016: Annals of African Medicine
https://www.readbyqxmd.com/read/27833342/hard-and-soft-tissue-changes-following-maxillary-distraction-osteogenesis-and-mandibular-setback-with-bilateral-sagittal-split-osteotomy
#8
Shilpa S Bawane, Neelam N Andrade
AIMS OF THIS STUDY: (1) To highlight the role of intraoral submerged device in distraction osteogenesis (DO) of patients requiring two jaw surgeries for the correction of severe developmental maxillary hypoplasia (MH) and mandibular prognathism (MP) (2) To analyse the hard and soft tissue changes following maxillary DO and mandibular setback with bilateral sagittal split osteotomy (BSSO) in patients with severe MH and MP requiring two jaw surgeries. MATERIALS AND METHODS: During the period Jan 2004 to Dec 2006, five patients with severe developmental MH along with MP were treated...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27813611/moquiniastrum-polymorphum-subsp-floccosum-extract-screening-for-mutagenic-and-antimutagenic-activity
#9
R J Oliveira, N de David, J R Pesarini, T D Nogueira, C A L Kassuya, R L B Strapasson, M E A Stefanello, A C D Monreal, R Matuo, A C M B Antoniolli-Silva
Moquiniastrum polymorphum subsp floccosum (Cabrera) G. Sancho is used in traditional Brazilian medicine to treat inflammation and infection, which is supported by scientific data. However, only one study has been conducted on the mutagenic activity of the extract, which has important safety implications. This study evaluated the mutagenic/antimutagenic activity of M. polymorphum ethanolic extract (MPEE) in Allium cepa meristematic cells. Commercial A. cepa seeds were cultured for 120 h. Treatments were performed for 48 h with MPEE (10 mg/mL), methyl methanesulfonate (MMS; 0...
October 24, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27803455/influence-of-styrax-camporum-and-of-chemical-markers-egonol-and-homoegonol-on-dna-damage-induced-by-mutagens-with-different-mechanisms-of-action
#10
Pollyanna Francielli de Oliveira, Jaqueline Lopes Damasceno, Heloiza Diniz Nicolella, Camila Spereta Bertanha, Patrícia Mendonça Pauletti, Denise Crispim Tavares
This study evaluated the influence of Styrax camporum stems hydroalcoholic extract (SCHE) and of chemical markers of the genus, egonol (EG) and homoegonol (HE), on DNA damage induced in V79 cells by mutagens with different mechanisms of action. These natural products were combined with different mutagens [methyl methanesulfonate (MMS), hydrogen peroxide (H2O2), (S)-(+)-camptothecin (CPT), and etoposide (VP-16)] to evaluate the modulatory effect on DNA damage. The results showed that SCHE was genotoxic at the highest concentration tested (60 µg/mL)...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27797107/parameterization-of-spectral-baseline-directly-from-short-echo-time-full-spectra-in-1-h-mrs
#11
Hyeong Hun Lee, Hyeonjin Kim
PURPOSE: To investigate the feasibility of parameterizing macromolecule (MM) resonances directly from short echo time (TE) spectra rather than pre-acquired, T1 -weighted, metabolite-nulled spectra in (1) H-MRS. METHODS: Initial line parameters for metabolites and MMs were set for rat brain spectra acquired at 9.4 Tesla upon a priori knowledge. Then, MM line parameters were optimized over several steps with fixed metabolite line parameters. The proposed method was tested by estimating metabolite T1 ...
October 31, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27792387/rippled-quasiperpendicular-shock-observed-by-the-magnetospheric-multiscale-spacecraft
#12
A Johlander, S J Schwartz, A Vaivads, Yu V Khotyaintsev, I Gingell, I B Peng, S Markidis, P-A Lindqvist, R E Ergun, G T Marklund, F Plaschke, W Magnes, R J Strangeway, C T Russell, H Wei, R B Torbert, W R Paterson, D J Gershman, J C Dorelli, L A Avanov, B Lavraud, Y Saito, B L Giles, C J Pollock, J L Burch
Collisionless shock nonstationarity arising from microscale physics influences shock structure and particle acceleration mechanisms. Nonstationarity has been difficult to quantify due to the small spatial and temporal scales. We use the closely spaced (subgyroscale), high-time-resolution measurements from one rapid crossing of Earth's quasiperpendicular bow shock by the Magnetospheric Multiscale (MMS) spacecraft to compare competing nonstationarity processes. Using MMS's high-cadence kinetic plasma measurements, we show that the shock exhibits nonstationarity in the form of ripples...
October 14, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27792059/vitamin-d-receptor-immunohistochemistry-variability-in-sun-exposed-and-non-sun-exposed-melanomas
#13
Giovanni Paolino, Chiara Panetta, Carlo Cota, Dario Didona, Elisa Moliterni, Cinzia Di Mattia, Gaetano De Vita, Ugo Bottoni, Pietro Donati, Stefano Calvieri
Ultraviolet rays are one of the leading factors in the development of melanoma (MM); however, ultraviolet rays seem not to play a role in non-sun-exposed MM, where systemic immunosuppression, anatomical, and physiological features may contribute toward the development of the malignancy. Our aim was to evaluate vitamin D receptor (VDR) expression in shield-site melanoma (ST-MM) and non-shield-site melanoma (NST-MM) to find features that could explain the different biological behavior of MM according to the area of onset...
October 27, 2016: Melanoma Research
https://www.readbyqxmd.com/read/27792058/clinical-features-and-response-to-systemic-therapy-in-a-historical-cohort-of-advanced-or-unresectable-mucosal-melanoma
#14
Alexander N Shoushtari, Mark J Bluth, Debra A Goldman, Christiana Bitas, Robert A Lefkowitz, Michael A Postow, Rodrigo R Munhoz, Gauri Buchar, Robert H Hester, Jacqueline A Romero, Laura J Fitzpatrick, Martin R Weiser, Katherine S Panageas, Jedd D Wolchok, Paul B Chapman, Richard D Carvajal
There are very few data available regarding the pattern of first metastases in resected mucosal melanomas (MMs) as well as the response of advanced MM to cytotoxic therapy. A retrospective, single-institution cohort was assembled of all patients with advanced/unresectable MM between 1995 and 2012 who had received systemic therapy with available imaging (N=81). Responses to first-line and second-line systemic therapy were assessed using Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. The relationship between response, overall survival, and clinical covariates was investigated using Cox proportional hazards regression...
October 27, 2016: Melanoma Research
https://www.readbyqxmd.com/read/27787485/moyamoya-vasculopathy-shows-a-genetic-mutational-gradient-decreasing-from-east-to-west
#15
Alessandro Raso, Roberto Biassoni, Samantha Mascelli, Paolo Nozza, Elisabetta Ugolotti, Eddi DI Marco, Patrizia DE Marco, Elisa Merello, Armando Cama, Marco Pavanello, Valeria Capra
BACKGROUND: Moyamoya disease (MMD) is a chronic, occlusive cerebrovascular disease characterized by bilateral steno- occlusive changes at the terminal portion of the internal carotid arteries and an abnormal vascular network at the base of the brain determining stroke in children. Patients with a similar vasculopathy and associated conditions are affected by the moyamoya syndrome (MMS). Most of the studies focused on MMD were carried out on East-Asian population. Ring Finger 213 (RNF213) has been identified as the strongest susceptibility gene for MMD in East-Asian people...
October 27, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27775078/loss-of-cyld-expression-unleashes-wnt-signaling-in-multiple-myeloma-and-is-associated-with-aggressive-disease
#16
H van Andel, K A Kocemba, A de Haan-Kramer, C H Mellink, M Piwowar, A Broijl, M van Duin, P Sonneveld, M M Maurice, M J Kersten, M Spaargaren, S T Pals
Deletion or mutation of the gene encoding the deubiquitinating enzyme CYLD is a common genomic aberration in multiple myeloma (MM). However, the functional consequence of CYLD loss and the mechanism underlying its putative role as a tumor suppressor gene in the pathogenesis of MM has not been established. Here, we show that CYLD expression is highly variable in myeloma cell lines and primary MMs and that low CYLD expression is associated with disease progression from monoclonal gammopathy of undetermined significance to MM, and with poor overall and progression free-survival of MM patients...
October 24, 2016: Oncogene
https://www.readbyqxmd.com/read/27767392/testing-of-schefflera-vinosa-extract-in-mammalian-cells-in-vitro-and-in-vivo-for-potential-toxicity-genetic-damage-and-role-of-oxidation
#17
Natália Helen Ferreira, Kelly Jacqueline Barbosa de Andrade, Luís Fernando Leandro, Nathália Oliveira Acésio, Suzana Amorim Mendes, Lucas Silva Cintra, Ana Helena Januário, Denise Crispim Tavares
The aim of this study was to examine the cytotoxic and genotoxic potential of a hydroethanolic extract of Schefflera vinosa (SV), a plant with schistosomicidal activity, as well as its influence on DNA damage induced by different mutagens, methyl methane sulfonate (MMS) and hydrogen peroxide (H2O2), in V79 cells and Swiss mice. Schefflera vinosa extract produced cytotoxicity at concentrations of 312.5 µg/ml or higher using the XTT cell proliferation assay kit. Treatment of V79 cell cultures with the highest SV concentration tested (150 µg/ml) significantly increased the frequency of micronuclei (MN) compared to controls...
October 21, 2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27757333/the-economics-of-skin-cancer-an-analysis-of-medicare-payment-data
#18
Jenny T Chen, Steven J Kempton, Venkat K Rao
: The incidence and cost of nonmelanoma skin cancers are skyrocketing. Five million cases cost $8.1 billion in 2011. The average cost of treatment per patient increased from $1000 in 2006 to $1600 in 2011. We present a study of the economics and costs of skin cancer management in Medicare patients. METHODS: We studied data released by the Centers for Medicare and Medicaid Services in 2014. Treatment modalities for the management of skin cancer were reviewed, and costs of treatment were quantified for a sample of 880,000 providers...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27756586/the-effect-of-hla-allele-and-haplotype-polymorphisms-on-donor-matching-in-hematopoietic-stem-cell-transplantation-croatian-experience
#19
Zorana Grubic, Katarina Stingl Jankovic, Marija Maskalan, Ranka Serventi-Seiwerth, Mirta Mikulic, Damir Nemet, Marija Burek Kamenaric, Boris Labar, Renata Zunec
The knowledge of HLA characteristics of a patient's population helps to predict the probability of finding a MUD. The study included transplanted 170 patients for whom a search for a MUD in BMDW was performed and a sample of 4000 volunteer unrelated donors from the Croatian Bone Marrow Donor Registry (CBMDR). Patients and their MUDs were typed for HLA-A, -B, -C, -DRB1, and -DQB1 loci using PCR-SSO and PCR-SSP methods while donors were typed for HLA-A, -B, -C and -DRB1 loci using the PCR-SSO method. A comparison of allele frequencies at tested HLA loci between patients and donors from CBMDR did not reveal significant differences...
October 15, 2016: Human Immunology
https://www.readbyqxmd.com/read/27755173/management-of-mucosal-basal-cell-carcinoma-of-the-lip-an-update-and-comprehensive-review-of-the-literature
#20
Tiffany Loh, Ashley G Rubin, Shang I Brian Jiang
BACKGROUND: Basal cell carcinoma (BCC) is the most common malignancy in the United States. Most BCCs occur on cutaneous surfaces, but rare cases on the mucosal lip have also been documented. Because only a small number of mucosal BCC (mBCC) cases have been reported, data on their clinical characteristics and management are limited. OBJECTIVE: To perform an updated literature review of the management of mBCCs on the lip. METHODS: A comprehensive literature review was conducted through a search of the PubMed database with the key phrases "mucosal basal cell carcinoma," "basal cell carcinoma mucosa," and "basal cell carcinoma lip mucosa...
December 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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