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https://www.readbyqxmd.com/read/29450912/association-of-clinicopathological-features-of-melanoma-with-total-naevus-count-and-a-history-of-dysplastic-naevi-a-cross-sectional-retrospective-study-within-an-academic-centre
#1
S Y Tan, L C Strazzulla, X Li, J J Park, S J Lee, C C Kim
BACKGROUND: High naevus count (HNC) (≥ 50 naevi) and presence of dysplastic naevi (DN) are risk factors for malignant melanoma (MM); however, MMs also occur in patients with low naevus count (LNC) (< 50 naevi) and in patients without DN. Little is known about differences between MMs in these groups. AIM: To characterize the clinicopathological differences between MMs in patients with HNC and those in patients with LNC, with or without biopsy-proven DN. METHODS: This was a cross-sectional retrospective chart review of 281 patients with MM seen between April 2013 and March 2014 at an academic pigmented lesion clinic (Boston, MA, USA)...
February 16, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29447176/cost-effectiveness-of-prenatal-food-and-micronutrient-interventions-on-under-five-mortality-and-stunting-analysis-of-data-from-the-minimat-randomized-trial-bangladesh
#2
Pernilla Svefors, Katarina Ekholm Selling, Rubina Shaheen, Ashraful Islam Khan, Lars-Åke Persson, Lars Lindholm
INTRODUCTION: Nutrition interventions may have favourable as well as unfavourable effects. The Maternal and Infant Nutrition Interventions in Matlab (MINIMat), with early prenatal food and micronutrient supplementation, reduced infant mortality and were reported to be very cost-effective. However, the multiple micronutrients (MMS) supplement was associated with an increased risk of stunted growth in infancy and early childhood. This unfavourable outcome was not included in the previous cost-effectiveness analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29444962/multiple-anomalies-in-the-origin-and-course-of-vertebral-arteries-and-aberrant-right-subclavian-artery-in-a-child-with-moyamoya-syndrome
#3
Pınar Beyaz, Nadia Khan, Gerasimos Baltsavias
Here we report, for the first time, a combination of five-vessel aortic arch, anomalous origin of the right vertebral artery (VA) from the common carotid artery (CCA), an aberrant right subclavian artery (SCA), and bilateral symmetrical segmental agenesis of VAs.In this case report, we present a patient with moyamoya syndrome (MMS) and Down syndrome (DS) who has bilateral symmetrical segmental agenesis of VAs, left VA originating from aortic arch and anomalous origin of right VA arising from CCA in combination with an aberrant right SCA...
February 14, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29443929/claimed-effects-outcome-variables-and-methods-of-measurement-for-health-claims-on-foods-related-to-vision-proposed-under-regulation-ec-1924-2006
#4
Daniela Martini, Augusto Innocenti, Chiara Cosentino, Giorgio Bedogni, Donato Angelino, Beatrice Biasini, Ivana Zavaroni, Marco Ventura, Daniela Galli, Prisco Mirandola, Marco Vitale, Alessandra Dei Cas, Riccardo C Bonadonna, Giovanni Passeri, Carlo Pruneti, Daniele Del Rio
Adequate visual function has a strong impact on the quality of life of people. Several foods and food components have been hypothesized to play a role in the maintenance of normal visual function and in the prevention of eye diseases. Some of these foods/food components have been the object of a request of authorization for use of health claims under Articles 13(5) or 14 of the Regulation (EC) 1924/2006. Most of these requests have received a negative opinion from the European Food Safety Authority (EFSA) due to the choice of inappropriate outcome variables (OVs) and/or methods of measurement (MMs) applied in the studies used to substantiate the claims...
February 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29438506/dna-repair-activity-of-fe-ii-2og-dependent-dioxygenases-affected-by-low-iron-level-in-saccharomyces-cerevisiae
#5
Akula Deepa, Kodipelli Naveena, Roy Anindya
Iron deprivation induces transcription of genes required for iron uptake and transcription factor Aft1 and Aft2 mediate this by regulating transcriptional program in S. cerevisiae. Iron-dependent Fe(II) and 2-oxoglutarate-dependent dioxygenase family proteins are involved in various cellular pathways including DNA alkylation damage repair. Whether Aft1/Aft2 are required for DNA alkylation repair is currently unknown. In this report, we have analyzed DNA alkylation repair under iron-deprived condition. S. cerevisiae Tpa1 is a member of Fe(II) and 2-oxoglutarate-dependent dioxygenase family and we show that deletion of AFT1 and AFT2 genes affects Tpa1 function resulting in sensitivity to alkylating agent MMS...
February 9, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29417049/stress-resilience-of-spermatozoa-and-blood-mononuclear-cells-without-prion-protein
#6
Malin R Reiten, Giulia Malachin, Elisabeth Kommisrud, Gunn C Østby, Karin E Waterhouse, Anette K Krogenæs, Anna Kusnierczyk, Magnar Bjørås, Clara M O Jalland, Liv Heidi Nekså, Susan S Røed, Else-Berit Stenseth, Frøydis D Myromslien, Teklu T Zeremichael, Maren K Bakkebø, Arild Espenes, Michael A Tranulis
The cellular prion protein PrPC is highly expressed in neurons, but also present in non-neuronal tissues, including the testicles and spermatozoa. Most immune cells and their bone marrow precursors also express PrPC. Clearly, this protein operates in highly diverse cellular contexts. Investigations into putative stress-protective roles for PrPC have resulted in an array of functions, such as inhibition of apoptosis, stimulation of anti-oxidant enzymes, scavenging roles, and a role in nuclear DNA repair. We have studied stress resilience of spermatozoa and peripheral blood mononuclear cells (PBMCs) derived from non-transgenic goats that lack PrPC (PRNPTer/Ter) compared with cells from normal (PRNP+/+) goats...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29411658/antioxidant-properties-and-anti-mutagenic-potential-of-piper-cubeba-fruit-extract-and-molecular-docking-of-certain-bioactive-compounds
#7
Maryam Zahin, Mohammad Shavez Khan, Faizan Abul Qais, Hussein Hasan Abulreesh, Iqbal Ahmad
Spices and herbs are recognized as sources of natural antioxidants and thus play an important role in the chemoprevention of diseases and aging. Piper cubeba is one among them and known for its medicinal properties for decades. Various biological activities are associated with its extract and phytocompounds. However, the anti-mutagenic activity of antioxidant rich extract is less explored. In this study, we performed the fraction-based antioxidant activity of P. cubeba using four different assays and evaluated the anti-mutagenic activity of most potent antioxidant fraction using Salmonella typhimurium tester strains against four mutagens (methyl methanesulfonate [MMS], sodium azide [SA], benzo(a)pyrene, and 2-aminoflourene) respectively...
February 7, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29406486/web-app-and-text-message-based-patient-education-in-mohs-micrographic-surgery-a-randomized-controlled-trial
#8
Spencer D Hawkins, Sarah B Koch, Phillip M Williford, Steven R Feldman, Daniel J Pearce
BACKGROUND: Consent and wound care (WC) videos are used for education in Mohs micrographic surgery (MMS). Postoperative text messaging is poorly studied. OBJECTIVE: Develop and evaluate perioperative resources for MMS patients-video modules (DermPatientEd.com) and postoperative text messaging (DermTexts.com). MATERIALS AND METHODS: A study was conducted on 90 MMS patients. Patients were randomized 1:1:1:1 to videos with text messages, videos-only, text messages-only, or control...
February 5, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29403363/a-retrospective-2d-morphometric-analysis-of-adult-female-chiari-type-i-patients-with-commonly-reported-and-related-conditions
#9
Maggie S Eppelheimer, James R Houston, Jayapalli R Bapuraj, Richard Labuda, Dorothy M Loth, Audrey M Braun, Natalie J Allen, Soroush Heidari Pahlavian, Dipankar Biswas, Aintzane Urbizu, Bryn A Martin, Cormac O Maher, Philip A Allen, Francis Loth
Purpose: Researchers have sought to better understand Chiari type I malformation (CMI) through morphometric measurements beyond tonsillar position (TP). Soft tissue and bone structures within the brain and craniocervical junction have been shown to be different for CMI patients compared to healthy controls. Yet, several morphological characteristics have not been consistently associated with CMI. CMI is also associated with different prevalent conditions (PCs) such as syringomyelia, pseudotumor, Ehlers-Danlos syndrome (EDS), scoliosis, and craniocervical instability...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29400739/slowing-down-light-using-terahertz-semiconductor-metamaterial-for-dual-band-thermally-tunable-modulator-applications
#10
Zohreh Vafapour
Compared to the neighboring infrared and microwave regions, the terahertz regime is still in need of fundamental technological advances. We have designed a terahertz (THz) semiconductor metamaterial (MM) waveguide system, which exhibits a significant slow-light effect, based on a classical electromagnetically induced transparency phenomenon. The potential of MMs for THz radiation originates from a resonant electromagnetic response that can be tailored for specific applications. By appropriately adjusting the distance between the two radiative and nonradiative modes, a flat band corresponding to a nearly constant group index (of the order of 4924) in the THz regime can be achieved...
February 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29399431/simultaneous-remote-observations-of-intense-reconnection-effects-by-dmsp-and-mms-spacecraft-during-a-storm-time-substorm
#11
A Varsani, R Nakamura, V A Sergeev, W Baumjohann, C J Owen, A A Petrukovich, Z Yao, T K M Nakamura, M V Kubyshkina, T Sotirelis, J L Burch, K J Genestreti, Z Vörös, M Andriopoulou, D J Gershman, L A Avanov, W Magnes, C T Russell, F Plaschke, Y V Khotyaintsev, B L Giles, V N Coffey, J C Dorelli, R J Strangeway, R B Torbert, P-A Lindqvist, R Ergun
During a magnetic storm on 23 June 2015, several very intense substorms took place, with signatures observed by multiple spacecraft including DMSP and Magnetospheric Multiscale (MMS). At the time of interest, DMSP F18 crossed inbound through a poleward expanding auroral bulge boundary at 23.5 h magnetic local time (MLT), while MMS was located duskward of 22 h MLT during an inward crossing of the expanding plasma sheet boundary. The two spacecraft observed a consistent set of signatures as they simultaneously crossed the reconnection separatrix layer during this very intense reconnection event...
November 2017: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/29399284/proton-nuclear-magnetic-resonance-based-metabonomic-models-for-non-invasive-diagnosis-of-liver-fibrosis-in-chronic-hepatitis-c-optimizing-the-classification-of-intermediate-fibrosis
#12
Andrea Dória Batista, Carlos Jonnatan Pimentel Barros, Tássia Brena Barroso Carneiro Costa, Michele Maria Gonçalves de Godoy, Ronaldo Dionísio Silva, Joelma Carvalho Santos, Mariana Montenegro de Melo Lira, Norma Thomé Jucá, Edmundo Pessoa de Almeida Lopes, Ricardo Oliveira Silva
AIM: To develop metabonomic models (MMs), using 1 H nuclear magnetic resonance (NMR) spectra of serum, to predict significant liver fibrosis (SF: Metavir ≥ F2), advanced liver fibrosis (AF: METAVIR ≥ F3) and cirrhosis (C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C (CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4). METHODS: Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included...
January 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29396855/use-of-a-novel-1-hour-protocol-for-rapid-frozen-section-immunocytochemistry-in-a-case-of-squamous-cell-carcinoma-treated-with-mohs-micrographic-surgery
#13
K Sinha, F Ali, G Orchard, W Rickaby, M Shams, R Mallipeddi, R Patalay
For squamous cell carcinoma (SCC) treated using Mohs micrographic surgery (MMS), interpretation of haematoxylin and eosin-stained frozen sections can be challenging. In these situations, ancillary use of immunostaining is a useful tool for the Mohs surgeon. However, use of immunostaining in MMS laboratories is limited, mainly because current manual immunostaining platforms are subject to operator error, and automated immunostaining, albeit accurate, is too slow for inclusion in MMS. In this report, we describe a novel 1-hour protocol for rapid frozen section immunocytochemistry, using the pancytokeratin markers AE1/AE3...
February 3, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29396601/rad5-coordinates-translesion-dna-synthesis-pathway-by-recognizing-specific-dna-structures-in-saccharomyces-cerevisiae
#14
Qifu Fan, Xin Xu, Xi Zhao, Qian Wang, Wei Xiao, Ying Guo, Yu V Fu
DNA repair is essential to maintain genome integrity. In addition to various DNA repair pathways dealing with specific types of DNA lesions, DNA damage tolerance (DDT) promotes the bypass of DNA replication blocks encountered by the replication fork to prevent cell death. Budding yeast Rad5 plays an essential role in the DDT pathway and its structure indicates that Rad5 recognizes damaged DNA or stalled replication forks, suggesting that Rad5 plays an important role in the DDT pathway choice. It has been reported that Rad5 forms subnuclear foci in the presence of methyl methanesulfonate (MMS) during the S phase...
February 2, 2018: Current Genetics
https://www.readbyqxmd.com/read/29389870/fermentability-of-novel-type-4-resistant-starches-in-in-vitro-system
#15
Jennifer M Erickson, Justin L Carlson, Maria L Stewart, Joanne L Slavin
Resistant starches are non-digestible starches that are fermented in the colon by microbiota. These carbohydrates are prebiotic and can be beneficial to consumer health. Many types of resistant starch exist with varying physical properties that may result in differences in fermentability. The objective of this research project was to compare potential prebiotic effects and fermentability of four novel resistant starches using an in vitro fermentation system and measuring changes in total gas production, pH, and formation of SCFAs (short chain fatty acids)...
February 1, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29388353/clinical-patterns-and-management-of-primary-mucosal-melanoma-a-single-centre-experience
#16
Yvonne Y R Ng, Grace H C Tan, Richard H H Quek, Mohamad B H R Farid, Khee Chee Soo, Melissa C C Teo
BACKGROUND: Primary mucosal melanomas (MM) are rare neoplasms arising from melanocytes in mucosal membranes. Delayed diagnosis and aggressive disease biology contribute to a poorer prognosis. The clinical patterns of MMs treated in a large tertiary centre, and the differences between MMs in the head and neck versus other anatomical sites are described. METHODS: A retrospective review of 43 patients diagnosed with MM in the head and neck, urogenital, esophageal and anorectal sites from 1993 to 2015 was conducted...
February 1, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29383587/claimed-effects-outcome-variables-and-methods-of-measurement-for-health-claims-proposed-under-european-community-regulation-1924-2006-in-the-area-of-blood-glucose-and-insulin-concentrations
#17
EDITORIAL
Daniela Martini, Beatrice Biasini, Ivana Zavaroni, Giorgio Bedogni, Marilena Musci, Carlo Pruneti, Giovanni Passeri, Marco Ventura, Daniela Galli, Prisco Mirandola, Marco Vitale, Alessandra Dei Cas, Riccardo C Bonadonna, Daniele Del Rio
Most requests for authorization to bear health claims under Articles 13(5) and 14 related to blood glucose and insulin concentration/regulation presented to the European Food Safety Authority (EFSA) receive a negative opinion. Reasons for such decisions are mainly ascribable to poor substantiation of the claimed effects. In this scenario, a project was carried out aiming at critically analysing the outcome variables (OVs) and methods of measurement (MMs) to be used to substantiate health claims, with the final purpose to improve the quality of applications provided by stakeholders to EFSA...
January 30, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29376748/claimed-effects-outcome-variables-and-methods-of-measurement-for-health-claims-on-foods-related-to-the-gastrointestinal-tract-proposed-under-regulation-ec-1924-2006
#18
Beatrice Biasini, Laura Marchi, Donato Angelino, Giorgio Bedogni, Ivana Zavaroni, Carlo Pruneti, Daniela Galli, Prisco Mirandola, Marco Vitale, Alessandra Dei Cas, Riccardo C Bonadonna, Giovanni Passeri, Marco Ventura, Daniele Del Rio, Daniela Martini
Most of the requests of authorisation to the use of health claims pursuant to Regulation EC 1924/2006 related to the gastrointestinal (GI) tract have received a negative opinion by the European Food Safety Authority (EFSA), mainly because of an insufficient substantiation of the claimed effect (CE). The present manuscript refers to the collection, collation and critical analysis of outcome variables (OVs) and methods of measurement (MMs) related to the GI tract compliant with Regulation 1924/2006. The critical evaluation of OVs and MMs was based on the literature review, with the final aim of defining their appropriateness in the context of a specific CE...
January 29, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29374799/application-of-ct-perfusion-to-assess-hemodynamics-in-symptomatic-moyamoya-syndrome-focus-on-affected-side-and-parameter-characteristic
#19
Shuran Huang, Lingyun Gao, Yueqin Chen, Xiang Guo, Deguo Liu, Jiehuan Wang, Zhitao Shi, Zhanguo Sun, Feng Jin, Weijian Chen, Yunjun Yang
OBJECTIVE: Vascular and hemodynamic changes were not consistent in symptomatic and non-symptomatic cerebral hemisphere in patients with symptomatic moyamoya syndrome (MMS). Thus, the purpose of this study is to evaluate the hemodynamic difference between symptomatic and non-symptomatic cerebral hemisphere in patients with symptomatic MMS. METHODS: Patients who were diagnosed with symptomatic MMS were retrospectively collected. All cases underwent CTP examination...
January 27, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29367356/multiple-anomalies-in-the-origin-and-course-of-vertebral-arteries-and-aberrant-right-subclavian-artery-in-a-child-with-moyamoya-syndrome
#20
Pınar Beyaz, Nadia Khan, Gerasimos Baltsavias
Here we report, for the first time, a combination of five-vessel aortic arch, anomalous origin of the right vertebral artery (VA) from the common carotid artery (CCA), an aberrant right subclavian artery (SCA), and bilateral symmetrical segmental agenesis of VAs.In this case report, we present a patient with moyamoya syndrome (MMS) and Down syndrome (DS) who has bilateral symmetrical segmental agenesis of VAs, left VA originating from aortic arch and anomalous origin of right VA arising from CCA in combination with an aberrant right SCA...
January 23, 2018: BMJ Case Reports
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