keyword
MENU ▼
Read by QxMD icon Read
search

Il1rap

keyword
https://www.readbyqxmd.com/read/30074426/global-transcriptome-difference-in-myokine-and-inflammatory-genes-in-muscle-of-mature-steer-progeny-is-related-to-maternal-lactation-diet-and-muscle-composition
#1
Theresa Casey, Joseph Walker, Ketaki P Bhide, Jyothi Thimmapuram, Jon Schoonmaker
Steer progeny suckled by cows fed a dried distillers grains and solubles (DDGS) diet the first three months of lactation were heavier during feedlot finishing and had significantly lower marbling and larger longissimus muscles than steer suckled by cows fed a control diet (CON). These differences were profound in that progeny were managed and fed identically from weaning until finishing, and findings suggested that the suckling period established the developmental program of muscle composition. Here transcriptomes of longissimus muscle were measured using next generation sequencing to investigate whether there were any developmental clues to the differences in marbling scores and muscle content between steers suckled by DDGS (n=5) versus control (CON; n=5) diet fed cows during lactation...
August 3, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29773641/il1rap-potentiates-multiple-oncogenic-signaling-pathways-in-aml
#2
Kelly Mitchell, Laura Barreyro, Tihomira I Todorova, Samuel J Taylor, Iléana Antony-Debré, Swathi-Rao Narayanagari, Luis A Carvajal, Joana Leite, Zubair Piperdi, Gopichand Pendurti, Ioannis Mantzaris, Elisabeth Paietta, Amit Verma, Kira Gritsman, Ulrich Steidl
The surface molecule interleukin-1 receptor accessory protein (IL1RAP) is consistently overexpressed across multiple genetic subtypes of acute myeloid leukemia (AML) and other myeloid malignancies, including at the stem cell level, and is emerging as a novel therapeutic target. However, the cell-intrinsic functions of IL1RAP in AML cells are largely unknown. Here, we show that targeting of IL1RAP via RNA interference, genetic deletion, or antibodies inhibits AML pathogenesis in vitro and in vivo, without perturbing healthy hematopoietic function or viability...
June 4, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29429992/srsf10-mediated-il1rap-alternative-splicing-regulates-cervical-cancer-oncogenesis-via-mil1rap-nf-%C3%AE%C2%BAb-cd47-axis
#3
Fei Liu, Miao Dai, Qinyang Xu, Xiaolu Zhu, Yang Zhou, Shuheng Jiang, Yahui Wang, Zhihong Ai, Li Ma, Yanli Zhang, Lipeng Hu, Qin Yang, Jun Li, Shujie Zhao, Zhigang Zhang, Yincheng Teng
High-risk human papillomavirus oncoproteins E6 and E7 are the major etiological factors of cervical cancer but are insufficient for malignant transformation of cervical cancer. Dysregulated alternative splicing, mainly ascribed to aberrant splicing factor levels and activities, contributes to most cancer hallmarks. However, do E6 and E7 regulate the expression of splicing factors? Does alternative splicing acts as an "accomplice" of E6E7 to promote cervical cancer progression? Here, we identified that the splicing factor SRSF10, which promotes tumorigenesis of cervix, was upregulated by E6E7 via E2F1 transcriptional activation...
May 2018: Oncogene
https://www.readbyqxmd.com/read/29424312/association-of-il33-and-il1rap-polymorphisms-with-acute-anterior-uveitis
#4
X-F Huang, W Chi, D Lin, M-L Dai, Y-L Wang, Y-M Yang, Z-B Jin, Y Wang
BACKGROUND: AAU (acute anterior uveitis) is the most common entity of uveitis characterized by acute vision loss and violent sore eyes. IL-33 and IL-1RacP have been found to play crucial roles in the innate immune system. OBJECTIVE: In the present study, we investigated the association of IL33 and IL1RAP genes with AAU. METHOD: A total of 549 AAU patients and 1080 unrelated healthy controls were recruited for this study. Ten single nucleotide polymorphisms (SNPs) were genotyped using Sequenom Mass ARRAY technology...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29238884/research-of-differential-expression-of-sil1rap-in-low-grade-gliomas-between-children-and-adults
#5
Jintao He, Xiang Li, Wanchun Zhu, Yaxiong Yu, Jian Gong
Glioma is the most common intracranial malignant tumor. Low-grade gliomas (LGG) occupy almost 80% in all of the gliomas. The prognosis of LGG in children is much better than in adult, however, the molecular mechanism is still unclear. In our investigation, it was first found that the level of soluble IL1RAP (sIL1RAP) was significantly higher in the LGG from children than that from adult. We also revealed that sIL1RAP could induce the apoptosis of U251. In cells with overexpression of sIL-1RAP, the cell proliferation promoted by IL-1 was significantly inhibited...
January 2018: Brain Tumor Pathology
https://www.readbyqxmd.com/read/29217619/microrna-4331-promotes-transmissible-gastroenteritis-virus-tgev-induced-mitochondrial-damage-via-targeting-rb1-upregulating-interleukin-1-receptor-accessory-protein-il1rap-and-activating-p38-mapk-pathway-in-vitro
#6
Xiaomin Zhao, Xiaoyuan Bai, Lijuan Guan, Juejun Li, Xiangjun Song, Xuelian Ma, Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang, Dewen Tong
Transmissible gastroenteritis virus (TGEV), a member of the coronaviridae family, could cause fatal diarrhea of piglets and result in numerous economic losses. Previous studies demonstrated that TGEV infection could lead to mitochondrial damage and upregulate miR-4331 level. So miR-4331 may play an important regulatory role in the control of mitochondrial function. To explore the potential role of miR-4331 in mitochondrial damage, we adopted a strategy consisting of quantitative proteomic analysis of porcine kidney (PK-15) cells in response to miR-4331 and TGEV infection...
February 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29103994/sputum-cell-il-1-receptor-expression-level-is-a-marker-of-airway-neutrophilia-and-airflow-obstruction-in-asthmatic-patients
#7
Michael D Evans, Stephane Esnault, Loren C Denlinger, Nizar N Jarjour
BACKGROUND: Various clinical, biologic, or physiologic markers of asthma have been used to identify patient clusters and potential targets for therapy. However, these identifiers frequently overlap among the different asthma groups. For instance, both eosinophil and neutrophil counts are often increased in the airways of asthmatic patients despite their typical association with type 2 and type 17 immune response, respectively. OBJECTIVES: We sought to determine whether inflammatory gene expression is related to patterns of airway inflammation and lung function and identify molecular markers for neutrophilic asthma...
December 26, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28159737/stem-and-progenitor-cell-alterations-in-myelodysplastic-syndromes
#8
REVIEW
Aditi Shastri, Britta Will, Ulrich Steidl, Amit Verma
Recent studies have demonstrated that myelodysplastic syndromes (MDSs) arise from a small population of disease-initiating hematopoietic stem cells (HSCs) that persist and expand through conventional therapies and are major contributors to disease progression and relapse. MDS stem and progenitor cells are characterized by key founder and driver mutations and are enriched for cytogenetic alterations. Quantitative alterations in hematopoietic stem and progenitor cell (HSPC) numbers are also seen in a stage-specific manner in human MDS samples as well as in murine models of the disease...
March 23, 2017: Blood
https://www.readbyqxmd.com/read/27738319/interleukin-1-blockade-overcomes-erlotinib-resistance-in-head-and-neck-squamous-cell-carcinoma
#9
Aditya Stanam, Katherine N Gibson-Corley, Laurie Love-Homan, Nnamdi Ihejirika, Andrean L Simons
Erlotinib has demonstrated poor clinical response rates for head and neck squamous cell carcinoma (HNSCC) to date and the majority of respondents acquire resistance to erlotinib relatively quickly. To elucidate novel pathways involved in erlotinib resistance, we compared the gene expression profiles of erlotinib-resistant (ER) vs. erlotinib-sensitive (ES) HNSCC cell lines. Enrichment analysis of microarray data revealed a deregulation of the IL-1 signaling pathway in ER versus ES-HNSCC cells. Gene expression of interleukin-1 alpha (IL1A) and interleukin-1 beta (IL1B) were significantly upregulated by > 2 fold in ER-SQ20B and ER-CAL 27 cells compared to their respective ES-cells...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27621309/il1rap-antibodies-block-il-1-induced-expansion-of-candidate-cml-stem-cells-and-mediate-cell-killing-in-xenograft-models
#10
Helena Ågerstam, Nils Hansen, Sofia von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, Marcus Järås, Thoas Fioretos
Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. As a consequence, CML stem cells persist and cause relapse in most patients upon drug discontinuation. Furthermore, no effective therapy exists for the advanced stages of the disease. Interleukin-1 receptor accessory protein (IL1RAP; IL1R3) is a coreceptor of interleukin-1 receptor type 1 and has been found upregulated on CML stem cells. Here, we show that primitive (CD34+ CD38- ) CML cells, in contrast to corresponding normal cells, express a functional interleukin-1 (IL-1) receptor complex and respond with NF-κB activation and marked proliferation in response to IL-1...
December 8, 2016: Blood
https://www.readbyqxmd.com/read/27546026/abnormal-expression-of-inflammatory-genes-in-placentas-of-women-with-sickle-cell-anemia-and-sickle-hemoglobin-c-disease
#11
Letícia C Baptista, Maria Laura Costa, Regiane Ferreira, Dulcinéia M Albuquerque, Carolina Lanaro, Kleber Y Fertrin, Fernanda G Surita, Mary A Parpinelli, Fernando F Costa, Mônica Barbosa de Melo
Sickle cell disease (SCD) is a complex disease that is characterized by the polymerization of deoxyhemoglobin S, altered red blood cell membrane biology, endothelial activation, hemolysis, a procoagulant state, acute and chronic inflammation, and vaso-occlusion. Among the physiological changes that occur during pregnancy, oxygen is consumed by fetal growth, and pregnant women with SCD are more frequently exposed to low oxygen levels. This might lead to red blood cells sickling, and, consequently, to vaso-occlusion...
October 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27334786/genes-involved-in-interleukin-1-receptor-type-ii-activities-are-associated-with-asthmatic-phenotypes
#12
Anne Marie Madore, Vanessa T Vaillancourt, Emmanuelle Bouzigon, Chloé Sarnowski, Florent Monier, Marie Hélène Dizier, Florence Demenais, Catherine Laprise
PURPOSE: Interleukin-1 (IL-1) plays a key role in inflammation and immunity and its decoy receptor, IL-1R2, has been implicated in transcriptomic and genetic studies of asthma. METHODS: Two large asthma family collections, the French-Canadian Saguenay-Lac-St-Jean (SLSJ) study and the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA), were used to investigate the association of SNPs in 10 genes that modulate IL-1R2 activities with asthma, allergic asthma, and atopy...
September 2016: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27240589/hepatic-expression-of-inflammatory-genes-and-micrornas-in-pigs-with-high-cholesteryl-ester-transfer-protein-cetp-activity
#13
Susanna Cirera, Benedicte C Juul Tørsleff, Christian Ritz, Merete Fredholm, Peter M H Heegaard, Kerstin Skovgaard
Human obesity and obesity-related diseases (ORD) are growing health problems worldwide and represent a major public health challenge. Most of these diseases are complex conditions, influenced by many genes (including microRNAs) and environmental factors. Many metabolic perturbations are associated with obesity; e.g., low levels of high-density lipoproteins (HDL) are high risk factors of cardiovascular events. A number of genetic, lifestyle, and environmental factors have been shown to contribute to the lowering of HDL-cholesterol...
October 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/27100611/targeting-microglia-for-the-treatment-of-alzheimer-s-disease
#14
REVIEW
Paul D Wes, Faten A Sayed, Frédérique Bard, Li Gan
While histological changes in microglia have long been recognized as a pathological feature of Alzheimer's disease (AD), recent genetic association studies have also strongly implicated microglia in the etiology of the disease. Coding and noncoding polymorphisms in several genes expressed in microglia-including APOE, TREM2, CD33, GRN, and IL1RAP-alter AD risk, and therefore could be considered as entry points for therapeutic intervention. Furthermore, microglia may have a substantial effect on current amyloid β (Aβ) and tau immunotherapy approaches, since they are the primary cell type in the brain to mediate Fc receptor-facilitated antibody effector function...
October 2016: Glia
https://www.readbyqxmd.com/read/27003612/proteomic-analysis-of-preovulatory-follicular-fluid-reveals-differentially-abundant-proteins-in-less-fertile-dairy-cows
#15
Maya Zachut, Pankaj Sood, Yishai Levin, Uzi Moallem
UNLABELLED: The follicular fluid (FF) proteome can provide an indication of follicular quality. High-yielding dairy cows suffer from low fertility, which could be related to follicular function. However, the proteome of preovulatory follicles has never been described in cows. Our objectives were to: 1) define the bovine preovulatory FF proteome, and 2) examine differentially abundant proteins in FF of controls (CTL, n=10) and less fertile cows (LFC; failed to conceive following ≥6 inseminations, n=8)...
April 29, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/26738723/transcriptional-analysis-of-porcine-intestinal-mucosa-infected-with-salmonella-typhimurium-revealed-a-massive-inflammatory-response-and-disruption-of-bile-acid-absorption-in-ileum
#16
Juber Herrera Uribe, Melania Collado-Romero, Sara Zaldívar-López, Cristina Arce, Rocío Bautista, Ana Carvajal, Susanna Cirera, M Gonzalo Claros, Juan J Garrido
Infected pork meat is an important source of non-typhoidal human salmonellosis. Understanding of molecular mechanisms involved in disease pathogenesis is important for the development of therapeutic and preventive strategies. Thus, hereby we study the transcriptional profiles along the porcine intestine during infection with Salmonella Typhimurium, as well as post-transcriptional gene modulation by microRNAs (miRNA). Sixteen piglets were orally challenged with S. Typhimurium. Samples from jejunum, ileum and colon, collected 1, 2 and 6 days post infection (dpi) were hybridized to mRNA and miRNA expression microarrays and analyzed...
January 7, 2016: Veterinary Research
https://www.readbyqxmd.com/read/26702414/profile-of-inflammation-associated-genes-during-hepatic-differentiation-of-human-pluripotent-stem-cells
#17
Joseph Ignatius Irudayam, Deisy Contreras, Lindsay Spurka, Songyang Ren, Vidhya Kanagavel, Arunachalam Ramaiah, Alagappan Annamalai, Samuel W French, Andrew S Klein, Vincent Funari, Vaithilingaraja Arumugaswami
Expression of genes associated with inflammation was analyzed during differentiation of human pluripotent stem cells (PSCs) to hepatic cells. Messenger RNA transcript profiles of differentiated endoderm (day 5), hepatoblast (day 15) and hepatocyte-like cells (day 21) were obtained by RNA sequencing analysis. When compared to endoderm cells an immature cell type, the hepatic cells (days 15 and 21) had significantly higher expression of acute phase protein genes including complement factors, coagulation factors, serum amyloid A and serpins...
December 2015: Data in Brief
https://www.readbyqxmd.com/read/26656881/a-whole-methylome-cpg-snp-association-study-of-psychosis-in-blood-and-brain-tissue
#18
Edwin J C G van den Oord, Shaunna L Clark, Lin Ying Xie, Andrey A Shabalin, Mikhail G Dozmorov, Gaurav Kumar, Vladimir I Vladimirov, Patrik K E Magnusson, Karolina A Aberg
Mutated CpG sites (CpG-SNPs) are potential hotspots for human diseases because in addition to the sequence variation they may show individual differences in DNA methylation. We performed methylome-wide association studies (MWAS) to test whether methylation differences at those sites were associated with schizophrenia. We assayed all common CpG-SNPs with methyl-CpG binding domain protein-enriched genome sequencing (MBD-seq) using DNA extracted from 1408 blood samples and 66 postmortem brain samples (BA10) of schizophrenia cases and controls...
July 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/26524021/-cloning-of-vh-and-vl-gene-of-human-anti-il1rap-mcab-and-construction-of-recombinant-chimeric-receptor
#19
Ling-Ling Yin, Su-Hong Ruan, Yu Tian, Kai Zhao, Kai Lin Xu
OBJECTIVE: To clone the variable region genes of human anti-IL1RAP (IL-1 receptor accessory protein) monoclonal antibodies (McAb) and to construct IL1RAP chimeric antigen receptors (CARs). METHODS: The VH and VL DNA of IL1RAP single chain antibodies were amplified by RACE and overlap extension PCR from total RNA extracted from 3H6E10 and 10D8A7 hybridoma and ligated into specific IL1RAP single-chain variable fragments (scFv). CD8α transmembrane domain, CD137 intracellular domain, TCR ζ chain, human CD8α signal peptide and scFv-anti-IL1RAP were cloned into plasmid LV-lac...
October 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26314426/-preparation-and-assessment-of-il1rap-monoclonal-antibody
#20
Ling-Ling Yin, Su-Hong Ruan, Yu Tian, Kai Lin Xu, Kai Zhao
OBJECTIVE: To prepare and identify human monoclonal antibody against IL-1 receptor accessory protein (IL1RAP), which is a new identified surface marker for leukemia stem cells (LSC). METHODS: BALB/c mice were inoculated intraperitoneally with hybridoma cells (3H6E10, 10D8A7) and their ascites were collected. The monoclonal antibody against hu-IL1RAP specifically was purified from ascites, the nondenaturing-PAGE, ELISA and Western blot were used to detect the purity, titer and sensitivity of antibody...
August 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
keyword
keyword
163156
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"