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Limb ischemic preconditioning

Qiang Yuan, Hui-Xian Jia, Shu-Qin Li, Xiao-Zhang, Yong-Juan Wu, Lin Feng, Xiao-Li Liu, Xiao-Cai Sun, Wen-Bin Li
Our previous studies have demonstrated that limb ischemic preconditioning (LIP) induced brain ischemic tolerance and up-regulated the expression of p38 MAPK and ERK in the hippocampal CA1 region in rats. The present study was undertaken to investigate the role of adenosine in brain protection and up-regulation of p38 MAPK and ERK induced by LIP. It was found that adenosine A1 receptor antagonist DPCPX dose-dependently inhibited the protective effect of LIP. The up-regulation of p38 MAPK and ERK induced by LIP could be blocked by DPCPX...
November 13, 2018: Brain Research
Fernando A Fierro, Nataly Magner, Julie Beegle, Heather Dahlenburg, Jeannine Logan White, Ping Zhou, Karen Pepper, Brian Fury, Dane Philip Coleal-Bergum, Gerhard Bauer, William Gruenloh, Geralyn Annett, Christy Pifer, Jan A Nolta
Mesenchymal stem/stromal cells (MSCs) may be able to improve ischemic conditions as they can actively seek out areas of low oxygen and secrete proangiogenic factors. In more severe trauma and chronic cases, however, cells alone may not be enough. Therefore, we have combined the stem cell and angiogenic factor approaches to make a more potent therapy. We developed an engineered stem cell therapy product designed to treat critical limb ischemia that could also be used in trauma-induced scarring and fibrosis where additional collateral blood flow is needed following damage to and blockage of the primary vessels...
November 1, 2018: Transfusion
Petra Kleinbongard, Nilguen Gedik, Mücella Kirca, Leanda Stoian, Ulrich Frey, Afsaneh Zandi, Matthias Thielmann, Heinz Jakob, Jürgen Peters, Markus Kamler, Gerd Heusch
Background Remote ischemic preconditioning ( RIPC ) by repeated brief cycles of limb ischemia/reperfusion attenuates myocardial ischemia/reperfusion injury. We aimed to identify a functional parameter reflecting the RIPC -induced protection in human. Therefore, we measured mitochondrial function in right atrial tissue and contractile function of isolated right atrial trabeculae before and during hypoxia/reoxygenation from patients undergoing coronary artery bypass grafting with RIPC or placebo, respectively...
August 7, 2018: Journal of the American Heart Association
Astrid Bergmann, Christian Breitling, Göran Hedenstierna, Anders Larsson, Moritz Kretzschmar, Alf Kozian, Thomas Hachenberg, Thomas Schilling
This article contains data on experimental endpoints of a randomized controlled animal trial. Fourteen healthy piglets underwent mechanical ventilation including injurious one-lung ventilation (OLV), seven of them experienced four cycles of remote ischemic preconditioning (RIP) on one hind limb immediately before OLV, seven of them did not receive RIP and served as controls, in a randomized manner. The two major endpoints were (1) pulmonary damage assessed with the diffuse alveolar damage (DAD) score and (2) the inflammatory response assessed by cytokine concentrations in serum and in bronchoalveolar lavage fluids (BAL)...
December 2018: Data in Brief
M Reinthaler, F Jung, K Empen
BACKGROUND: Remote ischemic preconditioning (RIPC) has been demonstrated to induce potent cardioprotection in individuals experiencing coronary ischemia. A protocol combining limb ischemia and electronic muscle stimulation of the ischemic skeletal muscle (RIPC+), performed in advance of coronary artery occlusion, was superior in terms of infarct size reduction when compared to RIPC alone. METHODS: This study was performed to evaluate the benefit of RIPC + in humans compared to a standard RIPC protocol and a control group...
October 9, 2018: Clinical Hemorheology and Microcirculation
Khalid Mt Ahmed, Shannon Hernon, Sara Mohamed, Muhammed Tubassum, Michael Newell, Stewart R Walsh
OBJECTIVE: To evaluate Remote ischaemic preconditioning in management of intermittent claudication patients BACKGROUND: Animal data suggest that remote ischaemic conditioning (RIC) can improve blood flow in ischaemic limbs and, consequently, may benefit claudication patients Supervised exercise is the preferred first-line intervention for patients with intermittent claudication (IC) but is constrained by limited availability and logistical issues, particularly in rural settings METHODS: We undertook a randomised clinical trial to evaluate RIC's effect in claudication patients...
September 29, 2018: Annals of Vascular Surgery
Min Hur, Sun-Kyung Park, Jungho Shin, Jung-Yoon Choi, Seokha Yoo, Won Ho Kim, Jin-Tae Kim
BACKGROUND: Acute kidney injury (AKI) may develop during partial nephrectomy due to ischemic reperfusion injury induced by renal artery clamping or surgical insult. The effect of remote ischemic preconditioning (RIPC) on reducing the renal injury after partial nephrectomy has not been evaluated in terms of urinary biomarkers. METHODS/DESIGN: We will conduct a randomized controlled trial enrolling the patients who will undergo partial nephrectomy. In the study group, RIPC which consisted of four 5-min cycles of limb ischemia and reperfusion will be conducted after induction of anesthesia...
September 4, 2018: Trials
Astrid Bergmann, Thomas Schilling, Göran Hedenstierna, Kerstin Ahlgren, Anders Larsson, Moritz Kretzschmar, Alf Kozian, Thomas Hachenberg
BACKGROUND: One-lung ventilation (OLV) may result in lung injury due to increased mechanical stress and tidal recruitment. As a result, a pulmonary inflammatory response is induced. The present randomized, controlled, animal experiment was undertaken to assess the effects of remote ischemic preconditioning (RIP) on diffuse alveolar damage and immune response after OLV. METHODS: Fourteen piglets (26 ± 2 kg) were randomized to control (n = 7) and RIP group (n = 7)...
August 31, 2018: Respiratory Physiology & Neurobiology
Philippe Richard, François Billaut
Elite athletes in varied sports typically combine ergogenic strategies in the hope of enhancing physiological responses and competitive performance, but the scientific evidence for such practices is very scarce. The peculiar characteristics of speed skating contribute to impede blood flow and exacerbate deoxygenation in the lower limbs (especially the right leg). We investigated whether combining preconditioning strategies could modify muscular oxygenation and improve performance in that sport. Using a randomized, single-blind, placebo-controlled, crossover design, seven male elite long-track speed skaters performed on-ice 600-m time trials, preceded by either a combination of preconditioning strategies (COMBO) or a placebo condition (SHAM)...
2018: Frontiers in Physiology
Yuansheng Xu, Qinkai Yu, Jianmin Yang, Fang Yuan, Yigang Zhong, Zhanlin Zhou, Ningfu Wang
Background: The aim of this study was to assess the acute hemodynamic effects of remote ischemic preconditioning (RIPC) on coronary perfusion pressure and coronary collateral blood flow. Methods: A total of 17 patients with coronary heart disease with severe (70%-85%) stenosis in one or two vessels confirmed by angiography were enrolled into this study. They were randomly divided into the RIPC group (9 patients) and the control group (8 patients). Distal pressure of coronary artery stenosis before balloon dilation (non-occlusive pressure, Pn-occl ) and distal coronary artery occlusive pressure (Poccl ) during balloon dilation occlusion were measured in all patients...
July 2018: Acta Cardiologica Sinica
Yong-Le Xu, Min-Hong Zhang, Wei Guo, Yan Xue, Xin Du, Tao Zhang, Na Wu, Ye Wu
Ischemia-reperfusion injury (IRI) is a severe problem patients diagnosed with acute limb ischemia. Recently, microRNAs (miR) have emerged as regulators of IRI as well as ischemic preconditioning and ischemic postconditioning. Therefore, using rat models, this study aims to explore all of the possible mechanisms that miR-19 exhibits with its relation to the transforming growth factor beta (TGF-β1)/Smad signaling pathway in the lower limb IRI. An immunofluorescence staining method was used to identify the Krueppel-like factor 10 (KLF10) positive expression and the location of KLF10 expression...
November 2018: Journal of Cellular Biochemistry
Henri Johannes Haapanen, Johanna Herajärvi, Hannu-Pekka Honkanen, Caius Mustonen, Hannu Tuominen, Ulla Puistola, Vesa Anttila, Tatu Juvonen
In experimental settings, remote ischemic preconditioning (RIPC) has shown a positive effect regarding spinal cord protection after local ischemia. In this study, we conducted spinal cord immunohistochemistry to demonstrate the protective effect of RIPC after 24 hours of the regional ischemia. Methods: Twenty piglets were randomized into an RIPC group (n = 10) and a control group (n = 10). The RIPC group underwent transient left hind limb ischemia before systematic left subclavian artery and segmental artery occlusion at the level of the diaphragm...
May 29, 2018: Heart Surgery Forum
Owen Jeffries, Mark Waldron, John R Pattison, Stephen D Patterson
Ischemic preconditioning (IPC), which involves intermittent periods of ischemia followed by reperfusion, is an effective clinical intervention that reduces the risk of myocardial injury and confers ischemic tolerance to skeletal muscle. Repeated bouts of IPC have been shown to stimulate long-term changes vascular function, however, it is unclear what metabolic adaptations may occur locally in the muscle. Therefore, we investigated 7 days of bilateral lower limb IPC (4 × 5 min) above limb occlusion pressure (220 mmHg; n = 10), or sham (20 mmHg; n = 10), on local muscle oxidative capacity and microvascular blood flow...
2018: Frontiers in Physiology
Chen Chen, Wei Jiang, Zongjian Liu, Fengwu Li, Jian Yang, Yanlong Zhao, Yuanyuan Ran, Yan Meng, Xunming Ji, Xiaokun Geng, Huishan Du, Xiaoming Hu
BACKGROUND: Remote ischemic preconditioning (RIPC) of a limb has been reported to protect against ischemic stroke. Our previous results demonstrated that the RIPC-mediated neuroprotection is associated with alterations in circulating immune cell populations. Here, we evaluated the effect of the spleen, the largest reservoir of immune cells, on RIPC-mediated neuroprotection against stroke. METHODS: Noninvasive RIPC was achieved by four repeated cycles of 5-min blood flow constriction in the hindlimbs using a tourniquet...
May 28, 2018: Journal of Neuroinflammation
John H Rosenberg, John H Werner, Michael J Moulton, Devendra K Agrawal
Ischemic preconditioning is a process which serves to mitigate reperfusion injury. Preconditioning of the heart can be achieved through natural, pharmacological, and mechanical means. Mechanical preconditioning appears to have the greatest chance of good outcomes while methods employing pharmacologic preconditioning have been largely unsuccessful. Remote ischemic preconditioning achieves a cardioprotective effect by applying cycles of ischemia and reperfusion in a distal limb, stimulating the release of a neurohumoral cardioprotective factor incited by stimulation of afferent neurons...
August 2018: Journal of Cardiovascular Translational Research
Philippe Richard, François Billaut
PURPOSE: Speed skating leads to blood-flow restriction and deoxygenation in the lower limbs (especially the right leg) that may affect performance. Although the acute influence of such deoxygenation is not clearly understood, we tested whether remote ischemic preconditioning (RIPC) could modify muscular oxygenation and improve time-trial performance in that sport. METHODS: Using a randomized, single-blind, placebo-controlled, crossover design, 9 elite speed skaters performed 1000-m on-ice time-trials preceded by either RIPC of the upper limbs (3x5-min compression/5-min reperfusion cycles at 30 mmHg > arterial systolic pressure) or SHAM (10 mmHg)...
May 10, 2018: International Journal of Sports Physiology and Performance
Luke Hughes, Owen Jeffries, Mark Waldron, Ben Rosenblatt, Conor Gissane, Bruce Paton, Stephen D Patterson
Background: Total arterial occlusive pressure (AOP) is used to prescribe pressures for surgery, blood flow restriction exercise (BFRE) and ischemic preconditioning (IPC). AOP is often measured in a supine position; however, the influence of body position on AOP measurement is unknown and may influence level of occlusion in different positions during BFR and IPC. The aim of this study was therefore to investigate the influence of body position on AOP. Methods: Fifty healthy individuals (age = 29 ± 6 y) underwent AOP measurements on the dominant lower-limb in supine, seated and standing positions in a randomised order...
2018: PeerJ
Hebe Agustina Mena, Paula Romina Zubiry, Blandine Dizier, Mirta Schattner, Catherine Boisson-Vidal, Soledad Negrotto
BACKGROUND: We have previously demonstrated that acidic preconditioning of human endothelial colony-forming cells (ECFC) increased proliferation, migration, and tubulogenesis in vitro, and increased their regenerative potential in a murine model of hind limb ischemia without baseline disease. We now analyze whether this strategy is also effective under adverse conditions for vasculogenesis, such as the presence of ischemia-related toxic molecules or diabetes, one of the main target diseases for cell therapy due to their well-known healing impairments...
May 2, 2018: Stem Cell Research & Therapy
André Heinen, Friederike Behmenburg, Aykut Aytulun, Maximilian Dierkes, Lea Zerbin, Wolfgang Kaisers, Maximilian Schaefer, Tanja Meyer-Treschan, Susanne Feit, Inge Bauer, Markus W Hollmann, Ragnar Huhn
BACKGROUND: Preclinical and proof-of-concept studies suggest a cardioprotective effect of remote ischemic preconditioning (RIPC). However, two major clinical trials (ERICCA and RIPHeart) failed to show cardioprotection by RIPC. Aging and gender might be confounding factors of RIPC affecting the inter-organ signalling. Theoretically, confounding factors might prevent the protective potency of RIPC by interfering with cardiac signalling pathways, i.e. at the heart, and/or by affecting the release of humoral factor(s) from the remote organ, e...
April 27, 2018: Journal of Translational Medicine
Kentaro Ejiri, Toru Miyoshi, Kunihisa Kohno, Makoto Nakahama, Masayuki Doi, Mitsuru Munemasa, Masaaki Murakami, Atsushi Takaishi, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND: The effect of remote ischemic preconditioning (RIPC) on periprocedural myocardial damage (pMD) in patients undergoing percutaneous coronary intervention (PCI) is controversial. The aim of this study was to investigate the effect of RIPC or intravenous nicorandil on pMD following elective PCI in a subgroup of patients with complex coronary lesions from a multicenter randomized controlled trial.Methods and Results:Patients with stable angina who underwent elective PCI were assigned to 3 groups: control, upper-limb RIPC or intravenous nicorandil...
June 25, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
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