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Xingsheng Zhao, Yu Ren, Hui Li, Yun Wu
BACKGROUND: Hypertension is the most common chronic disease, and most important risk factor for cardiovascular disease. This meta-analysis aimed to explore the association between hepatic lipase gene (LIPC) gene -250G/A (rs2070895) and -514C/T (rs1800588) polymorphisms and the susceptibility to hypertension. METHODS: Published studies were searched using the PubMed, Embase and Cochrane Library databases. Newcastle-Ottawa Scale (NOS) was used to assess the quality of the included studies...
October 15, 2018: Lipids in Health and Disease
J M Colijn, A I den Hollander, A Demirkan, A Cougnard-Grégoire, T Verzijden, E Kersten, M A Meester, B M J Merle, G Papageorgiou, S Ahmad, M T Mulder, M A Costa, P Benlian, G Bertelsen, A Bron, B Claes, C Creuzot-Garcher, M G Erke, S Fauser, P J Foster, C J Hammond, H W Hense, C B Hoyng, A P Khawaja, J Korobelnik, S Piermarocchi, T Segato, R Silva, E H Souied, K M Williams, C M van Duijn, C Delcourt, C C W Klaver
PURPOSE: Genetic and epidemiologic studies have shown that lipid genes and High Density Lipoproteins (HDL) are implicated in age-related macular degeneration (AMD). We studied circulating lipid levels in relation to AMD in a large European dataset, and investigated whether this relationship is driven by certain sub fractions. DESIGN: (Pooled) analysis of cross-sectional data. PARTICIPANTS: 30,953 individuals aged 50+ participating in the E3 consortium; and 1530 individuals from the Rotterdam Study with lipid sub fraction data...
October 10, 2018: Ophthalmology
Pablo Corral, Andrew S Geller, Eliana Y Polisecki, Graciela I Lopez, Virginia G Bañares, Leonardo Cacciagiu, Gabriela Berg, Robert A Hegele, Ernst J Schaefer, Laura E Schreier
BACKGROUND AND AIMS: Marked hypercholesterolemia, defined as low density lipoprotein cholesterol (LDL-C) levels ≥ 190 mg/dL, may be due to LDLR, APOB, and PCSK9 variants. In a recent analysis, only 1.7% of cases had such variants. Our goal was to identify other potential genetic causes of hypercholesterolemia. METHODS: In a total of 51,253 subjects with lipid testing, 3.8% had elevated total cholesterol >300 mg/dL and/or LDL-C≥190 mg/dL. Of these, 246 were further studied, and 69 without kidney, liver, or thyroid disease and who met Dutch Lipid Clinic Network criteria of ≥6 points had DNA sequencing done at the LDLR, APOB, PCSK9, APOE, LDLRAP1, STAP1, ABCG5, ABCG8, CYP27A1, LIPA, LIPC, LIPG, LPL, and SCARB1 gene loci and also had 10 SNP analysis for a weighted high LDL-C genetic risk score...
October 2018: Atherosclerosis
O Laguta, M Tuček, J van Slageren, P Neugebauer
Gaining access to electron spin dynamics at (sub-)THz frequencies is highly challenging. However, this information is highly relevant for the understanding and development of spin polarization agents in dynamic nuclear polarization methods and single-molecule magnets for quantum computation. Here we demonstrate the first rapid-scan EPR experiment in 200 GHz frequency region. A voltage controlled oscillator (VCO) generated fast sinusoidal frequency sweeps with scan rates up to 3×105  THz/s after the frequency multiplication, which is equal to 107  T/s in field representation...
September 19, 2018: Journal of Magnetic Resonance
Arindam Ghosh Mazumder, Vikram Patial, Damanpreet Singh
The role of neuroinflammatory mediators has been well established in the pathogenesis of temporal lobe epilepsy (TLE) and associated neurobehavioral comorbidities. Mycophenolate mofetil (MMF) is commonly used as an immunosuppressant in organ transplantations. Its neuroprotective effect is well explored in different preclinical and clinical studies. The present study was designed to investigate the effect of MMF in rat model of lithium pilocarpine (LiPc)-induced spontaneous recurrent seizures and its associated neurobehavioral comorbidities...
September 20, 2018: Brain, Behavior, and Immunity
Paula Costa-Urrutia, Carolina Abud, Valentina Franco-Trecu, Valentina Colistro, Martha Eunice Rodríguez-Arellano, Julio Granados, Marilia Seelaender
Pre diabetes mellitus (pre-DM) is considered an early-reversible condition that can progress to Type 2 diabetes mellitus (T2DM) which is the main cause of death for adult Mexican population. Gene variants influencing fasting glucose levels may constitute helpful tool for prevention purposes in pre-DM condition. Physically active Mexican-Mestizo adults (n=565) were genotyped for 6 single nucleotide polymorphisms (SNPs) (ADIPOQ rs2241766, ACSL1 rs9997745, LIPC rs1800588, PPARA rs1800206, PPARG rs1801282 and PPARGC1A rs8192678) related to lipid and carbohydrate metabolism...
October 2018: Primary Care Diabetes
Xuehua Liu, Junhua Zuo, Yuan Fang, Jing Wen, Feihong Deng, Hui Zhong, Bo Jiang, Jide Wang, Biao Nie
The drug resistance of cancer remains a major obstacle to successful chemotherapy. New strategies for improving chemotherapeutic efficacy are urgently required. Recent studies have indicated that LIPC plays a role in promoting the liver metastasis of colorectal cancer. In the present study, we aimed to investigate the effects of LIPC on theproliferation and clone formation of colorectal cancer-derived cells, and chemoresistance in hepatoblastoma-derived HepG2 cells. The activity and expression of LIPC were determined in the cell lines by RT-qPCR and western blot analysis...
October 2018: International Journal of Molecular Medicine
Ming-Zhen Yuan, Ruo-An Han, Chen-Xi Zhang, You-Xin Chen
Purpose: To assess the association of genes in the high-density lipoprotein metabolic pathway (HDLMP) with polypoidal choroidal vasculopathy (PCV) and the genetic difference in the HDLMP between PCV and age-related macular degeneration (AMD). Methods: We performed a literature search in EMBASE, PubMed, and Web of Science for genetic studies on 7 single nucleotide polymorphisms (SNPs) from 5 genes in the HDLMP including cholesteryl ester transfer protein (CETP), hepatic lipase (LIPC), lipoprotein lipase (LPL), ATP-binding cassette transporter A1 (ABCA1), and ATP-binding cassette transporter G1 (ABCG1) in PCV...
2018: Journal of Ophthalmology
S L Stvolinsky, N A Antonova, O I Kulikova, A V Lopachev, D A Abaimov, I Al-Baidani, O M Lopacheva, T N Fedorova, A P Kaplun, G M Sorokoumova
Synthesis of lipoilcarnosine (LipC) - a conjugated molecule based on two natural antioxidants, carnosine and a-lipoic acid, is described. Its physico-chemical, antioxidant properties and biological activity are characterized. According to reversed-phase HPLC with a UV detector, purity of the final product was 89.3%. The individuality of the obtained sodium salt of LipC was confirmed by tandem HPLC-mass spectrometry. High resistance of LipC to hydrolysis with serum carnosinase was demonstrated. The antioxidant activity of LipC measured by reaction with the formation of thiobarbituric acid reacting substances and kinetic parameters of iron-induced chemiluminescence was higher than that of carnosine and lipoic acid...
June 2018: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
Tianzhu Long, Shiling Lu, Hong Li, Rui Lin, Yingfen Qin, Li Li, Lulin Chen, Lulu Zhang, Yingnan Lv, Danyan Liang, Yaojie Liang, Lianguang Xie, Haisheng Yang, Chunting Dong, Haiying Zhang
BACKGROUND: Apolipoprotein B (APOB), and hepatic lipase (LIPC) genes have been shown to play a key role in lipid metabolism in type 2 diabetes (T2D). This study aimed to investigate the association of the three polymorphisms (rs679899 in APOB and rs6078 and rs6083 in LIPC) with T2D and related clinical quantitative traits. METHODS: We conducted a case-control study in Chinese Han population, with a total of 929 T2D patients and 1044 healthy subjects in Chinese Han population...
September 25, 2018: Gene
Lisa Y Lin, Qiang Zhou, Stephanie Hagstrom, Maureen G Maguire, Ebenezer Daniel, Juan E Grunwald, Daniel F Martin, Gui-Shuang Ying
Importance: Previous studies investigating the association of single-nucleotide polymorphisms (SNPs) that confer increased risk of age-related macular degeneration (AMD) with pseudodrusen have yielded conflicting results and have not evaluated other AMD SNPs or pseudodrusen subtypes. Objective: To determine the association of SNPs in the complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2), HtrA serine peptidase 1 (HTRA1), complement C2 (C2), complement C3 (C3), lipase C (LIPC), and complement factor B (CFB) genes with the presence of pseudodrusen and pseudodrusen subtypes (ie, dot, reticular, and confluent)...
June 1, 2018: JAMA Ophthalmology
Mislav Rakić, Leonardo Patrlj, Fedor Amić, Gorana Aralica, Ivica Grgurević
AIM: To compare and evaluate the hepatoprotective effect of remote ischemic preconditioning (RIPC) with local ischemic preconditioning (LIPC) of the liver during human liver resections. METHODS: A prospective, single-centre, randomised control trial was conducted in the Clinical Hospital "***" from April 2017 to January 2018. A total of 60 patients, who underwent liver resection due to colorectal cancer liver metastasis, were randomised to one of three study arms: 1) a RIPC group, 2) an LIPC group and 3) a control group (CG) in which no ischemic preconditioning was done before liver resection...
June 2018: International Journal of Surgery
J M McCaffery, J M Ordovas, G S Huggins, C-Q Lai, M A Espeland, D F Tate, R R Wing
BACKGROUND AND AIMS: Two weight gain prevention strategies, one targeting small changes to diet and physical activity and a second targeting large changes, significantly reduced weight gain in young adulthood. We examined whether weight gain prevention blunts genetic risk for body weight increase and/or high density lipoprotein cholesterol (HDL-C) lowering over two years. METHODS AND RESULTS: Participants were 524 male and female young adults (mean age = 28.2, SD = 4...
March 6, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Ismael San Mauro Martín, Javier Andrés Blumenfeld Olivares, Eva Pérez Arruche, Esperanza Arce Delgado, María José Ciudad Cabañas, Elena Garicano Vilar, Luis Collado Yurrita
Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over controlled clinical trial was carried out in 45 people (25 women)...
April 3, 2018: Diseases (Basel)
Ayano Enomoto, Chunqi Qian, Nallathamby Devasahayam, Shun Kishimoto, Nobu Oshima, Burchelle Blackman, Rolf E Swenson, James B Mitchell, Alan P Koretsky, Murali C Krishna
PURPOSE: To develop an implantable wireless coil with parametric amplification capabilities for time-domain electron paramagnetic resonance (EPR) spectroscopy operating at 300 MHz. METHODS: The wireless coil and lithium phthalocyanine (LiPc), a solid paramagnetic probe, were each embedded individually in a biocompatible polymer polydimethoxysiloxane (PDMS). EPR signals from the LiPc embedded in PDMS (LiPc/PDMS) were generated by a transmit-receive surface coil tuned to 300 MHz...
November 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Solomon Oladapo Rotimi, Isaacson Bababode Adelani, Goodness Esther Bankole, Oluwakemi Anuoluwapo Rotimi
Naringin, a citrus-derived flavonoid with antihyperglycemic, antihyperlipidemic, and antioxidant properties, is reported to be a useful nutraceutical in the management of diabetes and its complications. This study investigated the mechanism of antiatherogenic properties of naringin in type 2 diabetes (T2DM) using high fat-low streptozocin rat model of T2DM. Rats were treated daily with 50, 100 and 200 mg/kg naringin orally for 21days. Levels of biomarkers of T2DM, lipid profile and activity of paraoxonase (PON) were assayed spectrophotometrically...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tanya M Teslovich, Daniel Seung Kim, Xianyong Yin, Alena Stancáková, Anne U Jackson, Matthias Wielscher, Adam Naj, John R B Perry, Jeroen R Huyghe, Heather M Stringham, James P Davis, Chelsea K Raulerson, Ryan P Welch, Christian Fuchsberger, Adam E Locke, Xueling Sim, Peter S Chines, Narisu Narisu, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Vilmundur Gudnason, Solomon K Musani, Marjo-Riitta Jarvelin, Gerard D Schellenberg, Elizabeth K Speliotes, Johanna Kuusisto, Francis S Collins, Michael Boehnke, Markku Laakso, Karen L Mohlke
Comprehensive metabolite profiling captures many highly heritable traits, including amino acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better understand the contribution of genetic variation to amino acid levels, we performed single variant and gene-based tests of association between nine serum amino acids (alanine, glutamine, glycine, histidine, isoleucine, leucine, phenylalanine, tyrosine, and valine) and 16.6 million genotyped and imputed variants in 8545 non-diabetic Finnish men from the METabolic Syndrome In Men (METSIM) study with replication in Northern Finland Birth Cohort (NFBC1966)...
May 1, 2018: Human Molecular Genetics
Xi Yu, Talia Raney, Meaghan V Perdue, Jennifer Zuk, Ola Ozernov-Palchik, Bryce L C Becker, Nora M Raschle, Nadine Gaab
Numerous studies have shown that phonological skills are critical for successful reading acquisition. However, how the brain network supporting phonological processing evolves and how it supports the initial course of learning to read is largely unknown. Here, for the first time, we characterized the emergence of the phonological network in 28 children over three stages (prereading, beginning reading, and emergent reading) longitudinally. Across these three time points, decreases in neural activation in the left inferior parietal cortex (LIPC) were observed during an audiovisual phonological processing task, suggesting a specialization process in response to reading instruction/experience...
May 2018: Human Brain Mapping
Qi Yan, Ying Ding, Yi Liu, Tao Sun, Lars G Fritsche, Traci Clemons, Rinki Ratnapriya, Michael L Klein, Richard J Cook, Yu Liu, Ruzong Fan, Lai Wei, Gonçalo R Abecasis, Anand Swaroop, Emily Y Chew, Daniel E Weeks, Wei Chen
Family- and population-based genetic studies have successfully identified multiple disease-susceptibility loci for Age-related macular degeneration (AMD), one of the first batch and most successful examples of genome-wide association study. However, most genetic studies to date have focused on case-control studies of late AMD (choroidal neovascularization or geographic atrophy). The genetic influences on disease progression are largely unexplored. We assembled unique resources to perform a genome-wide bivariate time-to-event analysis to test for association of time-to-late-AMD with ∼9 million variants on 2721 Caucasians from a large multi-center randomized clinical trial, the Age-Related Eye Disease Study...
March 1, 2018: Human Molecular Genetics
D D Manavella, L Cacciottola, C M Desmet, B F Jordan, J Donnez, C A Amorim, M M Dolmans
STUDY QUESTION: Do two different concentrations of human adipose tissue-derived stem cells (ASCs) embedded inside a fibrin scaffold have the potential to differentiate into vessels and aid vascularization in a peritoneal grafting site intended for ovarian tissue transplantation? SUMMARY ANSWER: Human ASCs in low and high concentrations differentiated into vessels when transplanted to mouse peritoneum inside a fibrin matrix, but only high ASC concentrations significantly increased human vessel area 14 days after transplantation...
February 1, 2018: Human Reproduction
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