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Spleen ultrasound

Romina Grazia Giancipoli, Serena Monti, Olca Basturk, David Klimstra, Mary Louise Keohan, Orazio Schillaci, Giuseppe Corrias, Peter Sawan, Lorenzo Mannelli
RATIONALE: Hepatic epithelioid hemangioendothelioma (EHE) is a rare malignant vascular tumor of endothelial origin with a highly variable clinical presentation and natural history. Given its vascular origin, new therapies with inhibitors of vascular endothelial growth factor (VEGF) have been introduced in the treatment of these patients and have shown promising results. Few reports have described the role of F-Fluorodeoxyglucose positron emission tomography/contrast-enhanced computed tomography (F-FDG PET/CT) in the evaluation of this tumor after treatment with anti-angiogenic agents...
October 2018: Medicine (Baltimore)
C Sangüesa Nebot, E Carazo Palacios, R L Lorens Salvador, S Picó Aliaga
The spleen is considered a "forgotten organ" by most radiologists and paediatricians despite being affected in many clinical paediatric situations. While it is the organ most often affected in paediatric abdominal trauma, non-traumatic spleen disorders are less well known. The spleen is well visualised by any imaging technique: ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI); the former is used most often in children. Using imaging techniques to determine the features of splenic anomalies, both congenital and acquired, enables a correct diagnostic approach, avoids unnecessary surgical procedures or biopsies, and helps the clinician to prescribe appropriate treatment...
October 9, 2018: Radiología
Savio G Barreto, Ilse Dirkzwager, John A Windsor, Sanjay Pandanaboyana
BACKGROUND: Post-operative pancreatic fistulae (POPF) remain a major contributor to morbidity and mortality following pancreatic resection. Evidence for preoperative prediction of POPF based on cross-sectional imaging has not been systemically reviewed. This review aimed to determine whether preoperative imaging modalities can accurately predict the development of POPF. METHODS: A systematic review of major reference databases was undertaken, according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, up to May 2018...
October 10, 2018: ANZ Journal of Surgery
Michael Lipinski, Michael Saborowski, Benjamin Heidrich, Dina Attia, Philipp Kasten, Michael P Manns, Michael Gebel, Andrej Potthoff
OBJECTIVES: The clinical relevance of spontaneous portosystemic shunts detected by ultrasound is insufficiently investigated. The aim of this retrospective study was to assess the frequency and clinical relevance of spontaneous portosystemic shunts in patients with liver cirrhosis. METHODS: We evaluated portosystemic shunts, liver cirrhosis and spleen size by ultrasound in 982 patients with liver cirrhosis and correlated these with laboratory results, clinical data and the incidence of clinical endpoint deaths, liver transplantation and the development of HCC during the follow-up period (mean 1...
September 29, 2018: Scandinavian Journal of Gastroenterology
Kit Fai Lee, Hon Ting Lok, Andrew K Y Fung, Charing C N Chong, Yue Sun Cheung, John Wong, Paul B S Lai
A 51-year-old man who was a hepatitis B carrier presented with ruptured hepatocellular carcinoma (HCC). Hepatic arterial embolization was performed for control of bleeding which was followed by staged open left lateral sectionectomy for tumor removal. Pathology confirmed a 3.5 cm ruptured subcapsular HCC in a cirrhotic liver with clear resection margin. However, the alpha-fetoprotein (AFP) increased from 14 to 72 µg/L after 7 months. A 1.7 × 0.8 cm nodule at left subdiaphragmatic region abutting on the spleen but no intrahepatic lesion was seen on computed tomography (CT)...
September 29, 2018: Journal of Robotic Surgery
Mark D Stringer, Nathanael Lucas
Splenectomy is indicated in selected children with haemolytic anaemia. Postoperatively, thrombocytosis occurs in at least 80% and is one of the factors implicated in the development of acute portal venous thrombosis after splenectomy in adults. A literature review shows that children are also at risk of this complication, but the incidence is low. The risk is greatest in those with particularly large spleens. Laparoscopic splenectomy does not reduce the risk of this complication. Early detection and anticoagulation usually leads to successful resolution of the thrombosis and can mitigate the risk of developing cavernous transformation of the portal vein and chronic portal hypertension...
September 23, 2018: Journal of Paediatrics and Child Health
R Wiles, I Patanwala, B Hankinson, P Healey, C Farrell, C Griffin, L Bonnett, P Richardson
AIM: To determine whether acoustic radiation force imaging (ARFI) of the liver/spleen could be used in patients with cirrhosis to predict the presence of gastroesophageal varices (GOVs). MATERIALS AND METHODS: Fifty-eight patients with cirrhosis who were undergoing 6-monthly ultrasound examinations for hepatoma surveillance and who were due to have oesophagogastroduodenoscopy (OGD) within 6 months of their ultrasound were recruited. During routine ultrasound, the patient's liver and spleen were also assessed using ARFI...
September 21, 2018: Clinical Radiology
Barbara Cerroni, Rosella Cicconi, Letizia Oddo, Manuel Scimeca, Rita Bonfiglio, Roberta Bernardini, Graziana Palmieri, Fabio Domenici, Elena Bonanno, Maurizio Mattei, Gaio Paradossi
Microbubbles (MBs) are used in clinical practice as vascular ultrasound contrast agents, and are gaining popularity as a platform supporting multimodal imaging and targeted therapy, facilitating drug delivery under ultrasound exposure. Here, we report on the in vivo biological impact of newly discovered MBs with promising features as a multimodal theranostic device. The shell of the air-filled MBs is made of the poly(vinyl alcohol) (PVA), a well-established, FDA-approved polymer. Nevertheless, as size, shape and dispersity can significantly impact the biological response of particulate systems, studying their fate after administration is crucial...
September 2018: Heliyon
Corinna Trenker, Christian Görg, Christian Jenssen, Stefan Klein, Andreas Neubauer, Christoph F Dietrich
At the time of primary diagnosis, hematological diseases often present with unspecific symptoms, and abdominal sonography is performed as part of the initial diagnostic work-up. The detection of an enlarged spleen, of pathological lymph nodes or of other findings may help to suspect hematological diseases. Also, in case of suspected lymph node enlargement, sonography may be a first step. If detection of enlarged and pathological lymph nodes leads to suspicion of malignant lymphomas, examination of further lymph node stations may give an initial impression of the stage of disease and can help in planning further diagnostic strategies...
September 2018: Zeitschrift Für Gastroenterologie
Anderson V Huerta-Obando, Erick Y Olivera-Baca, Jaime Silva-Díaz, Abel Salazar-Díaz
Echinococcosis is a parasitic infection caused by Echinococcus granulosus, which, in its cystic state, forms the socalled hydatid cyst. It presents important morbidity, with possible sequelae related to the location, and high costs due to surgical and prolonged pharmacological treatment. The liver and the lung are the most common anatomical locations, and much rarer are the kidney, spleen, brain, and heart, where the latter represents 0.5 to 2% of total cases. Peru is an endemic country of this anthropozoonosis and mainly records cases in the central highlands (95%)...
April 2018: Revista Peruana de Medicina Experimental y Salud Pública
Ashley R Wilkinson, Susan V Carr, Shawna L Klahn, Nikolaos G Dervisis, Cory R Hanks
Case summary: A 12-year-old male castrated domestic shorthair cat was evaluated for a 10 month history of weight loss. Thin body condition and a grade II/VI systolic parasternal heart murmur was noted during examination. Moderate-to-severe anemia and intermittent thrombocytopenia were identified on serial complete blood counts. Antibodies against feline immunodeficiency virus (FIV) were detected, but vaccination for FIV occurred previously. Echocardiography revealed biatrial and biventricular enlargement, left ventricular hypertrophy and pericardial effusion...
July 2018: JFMS Open Reports
José Fernando Val-Bernal, María Martino, Elena Yllera-Contreras, Beatriz Castro-Senosiain, Pablo Bueno-Ortiz
Intrapancreatic accessory spleen (IPAS) is a congenital anomaly usually misdiagnosed as a pancreatic neoplasm. For five years and four months, we collected seven IPASs located in the tail of the pancreas in four patients diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). All cases had associated cell block preparations. Each patient underwent endoscopic ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) studies. The patients ranged in age from 57 to 73 years (mean age 65...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
R Rahimi, E Omar, T S Tuan Soh, S F A Mohd Nawi, S Md Noor
INTRODUCTION: Leptospirosis is a zoonotic disease caused by spirochaete of the genus Leptospira. Human infection occurs after exposure to water or soil contaminated by urine from an infected animal. Most patients manifest as self-limited systemic illness. However 10% of patients manifest as severe disease associated with high fatality. The disease affects mostly men, cases involving pregnant women are uncommon. We presented a case of leptospirosis in a pregnant woman leading to mortality of both mother and foetus...
August 2018: Malaysian Journal of Pathology
Olga Tsoref, Dalia Tyomkin, Uri Amit, Natalie Landa, Osnat Cohen-Rosenboim, David Kain, Moran Golan, Nili Naftali-Shani, Ayelet David, Jonathan Leor
Endothelial activation with up-regulation of E-selectin adhesion molecules mediates leukocyte rolling along the vascular wall and controls inflammation in many diseases including atherosclerosis and heart failure. Therefore, we aimed to test the hypothesis that inhibition of E-selectin-mediated interactions by a new E-selectin-targeted copolymer could inhibit the progression of atherosclerosis. To target E-selectin on activated endothelium, we developed a new N-(2-hydroxypropyl)methacrylamide (HPMA)-based E-selectin binding copolymer with or without dexamethasone (Dex) (designated P-(Esbp)-Dex and P-Esbp, respectively)...
October 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Valerie Wiles, Jamie Haddad, Nicole Leibman, Anne C Avery, Kelly L Hughes
A 12-y-old neutered male Portuguese Water dog was presented because of a 1-y history of persistent hyporexia, diarrhea, and recurrent pyelonephritis. Abdominal ultrasound revealed hepatic nodules and diffuse splenomegaly, and radiographs revealed a mediastinal mass. Fine-needle aspirates of the liver, spleen, and mediastinal mass were suspicious for lymphoma. Flow cytometry identified small T cells that co-expressed CD4 and CD8 at all sites, most suspicious for thymoma, but lymphoma could not be ruled out. PCR for antigen receptor rearrangements analysis identified polyclonal amplification of the T-cell receptor genes, more consistent with thymoma than lymphoma...
September 2018: Journal of Veterinary Diagnostic Investigation
Dong Wook Kim, Hee Mang Yoon, Ah Young Jung, Jin Seong Lee, Seak Hee Oh, Kyung Mo Kim, Young Ah Cho
OBJECTIVES: To assess the diagnostic performance of ultrasound (US) elastography in evaluating portal hypertension in children and compare the liver and spleen stiffness values between the portal hypertension and control groups. METHODS: Studies in the MEDLINE and Embase databases were selected that investigated the diagnostic performance of US elastography in children with portal hypertension up to December 21, 2017. Pooled sensitivity and specificity data were assessed by hierarchical logistic regression modeling...
August 16, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Lydia Giannitrapani, Walter Granà, Anna Licata, Cosima Schiavone, Giuseppe Montalto, Maurizio Soresi
OBJECTIVE: Non-selective β-blockers (NSBBs) are used in liver cirrhosis (LC) to prevent variceal bleeding because they decrease portal pressure. A main risk factor for the development of portal vein thrombosis (PVT) in LC is decreased portal vein inflow velocity. The aim of our study was to examine retrospectively the incidence of PVT and its correlation with the use of β-blockers in a cohort of LC patients. SUBJECTS AND METHODS: Data from 230 LC patients (90% Child-Pugh class A), who had been followed up for at least 5 years, were reviewed...
August 14, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Sara Anne Ruggiero, Jason Huber, Coral L Murrant, Keith R Brunt, Jeremy Andrew Simpson
During physiological stress (e.g. exercise, hypoxia) blood flow is shunted to specific anatomical regions to protect critical organs, yet, splenic blood flow in these circumstances remains to be investigated. Despite being classically viewed as a non-critical organ, recent experimental and epidemiological evidence suggests the spleen plays a significant role in cardiovascular pathophysiology. We hypothesized that splenic blood flow is prioritized in the development of heart failure (i.e. chronic state of reduced cardiac output)...
August 13, 2018: Canadian Journal of Physiology and Pharmacology
Yudai Fujiwara, Hidekatsu Kuroda, Tamami Abe, Kazuyuki Ishida, Takuma Oguri, Sachiyo Noguchi, Tamotsu Sugai, Naohisa Kamiyama, Yasuhiro Takikawa
The purpose of our study was to evaluate the diagnostic accuracy of the ultrasound-guided attenuation parameter (UGAP) for the detection of hepatic steatosis in comparison with the controlled attenuation parameter (CAP), using histopathology as the reference standard. We prospectively analyzed 163 consecutive chronic liver disease patients who underwent UGAP, CAP, computed tomography and a liver biopsy on the same day between April 2016 and July 2017. Radiofrequency signals corresponding to the images were compensated by the reference signal previously measured from the uniform phantom with known attenuation (0...
August 1, 2018: Ultrasound in Medicine & Biology
Birgit Tsaknakis, Rawan Masri, Ahmad Amanzada, Golo Petzold, Volker Ellenrieder, Albrecht Neesse, Steffen Kunsch
BACKGROUND: The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening markers for the presence of EV are of interest. Here, we aim to investigate whether non-inflammatory gall bladder wall thickening (GBWT) may serve as predictor for the presence of EV in comparison and combination with other non-invasive clinical and laboratory parameters. METHODS: One hundred ninety four patients were retrospectively enrolled in the study...
August 2, 2018: BMC Gastroenterology
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