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Adult onset stills

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https://www.readbyqxmd.com/read/30324816/anakinra-for-the-treatment-of-adult-onset-still-s-disease
#1
Santos Castañeda, Belén Atienza-Mateo, José L Martín-Varillas, José M Serra López-Matencio, Miguel A González-Gay
Adult onset Still's disease (AOSD) is an uncommon systemic inflammatory disease on the clinical spectrum of autoinflammatory disorders. Its presentation and clinical course may result in several well differentiated phenotypes: from a systemic and highly symptomatic pattern to a chronic articular pattern. Overproduction of numerous pro-inflammatory cytokines is observed in AOSD. Anakinra (ANK), a human interleukin (IL)-1R antagonist, has recently been approved in the EU for the treatment of AOSD. Areas covered: In this review, we discuss the main studies on the efficacy and safety on ANK for the treatment of AOSD...
October 16, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/30318016/noncaseating-suppurative-granulomatous-lymphadenitis-in-adult-onset-still-s-disease-a-diagnostic-dilemma-in-a-tuberculosis-endemic-region-a-case-report
#2
S W G J W Chinthaka, R L Satarasinghe, S Senanayake, W A P S R Weerarathne, A A M Anfaz, M P Deraniyagala
BACKGROUND: Lymphadenopathy is not an uncommon presentation of adult onset Still's disease: it is present in up to two thirds of patients with adult onset Still's disease. The characteristic appearance of lymphadenopathy is described as intense, paracortical immunoblastic hyperplasia. Changes in light microscopy may resemble lymphoma, but immunohistochemistry reveals a benign polyclonal B cell hyperplasia. CASE PRESENTATION: We describe a 67-year-old Sri Lankan woman who manifested relapsing prolonged fever, raised inflammatory markers, arthralgia, myalgia, transient skin rash, and cervical lymphadenopathy histologically characterized by noncaseating granulomatous adenitis with central suppuration...
October 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30317568/protein-malnutrition-mitigates-the-effects-of-a-high-fat-diet-on-glucose-homeostasis-in-mice
#3
Renato Chaves Souto Branco, Rafael Ludemann Camargo, Thiago Martins Batista, Jean Franciesco Vettorazzi, Camila Lubaczeuski, Lucas Henrique Montes Bomfim, Leonardo Reis Silveira, Antônio Carlos Boschero, Cláudio Cesar Zoppi, Everardo Magalhães Carneiro
Nutrient malnutrition, during the early stages of development, may facilitate the onset of metabolic diseases later in life. However, the consequences of nutritional insults, such as a high-fat diet (HFD) after protein restriction, are still controversial. We assessed overall glucose homeostasis and molecular markers of mitochondrial function in the gastrocnemius muscle of protein-restricted mice fed an HFD until early adulthood. Male C57BL/6 mice were fed a control (14% protein-control diet) or a protein-restricted (6% protein-restricted diet) diet for 6 weeks...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30316764/-urticaria-as-a-presentation-of-adult-onset-still-s-disease
#4
N Martín-Peña, M Dorval-Alcón, M L Méndez-Caro, C Zafra-Urango
No abstract text is available yet for this article.
October 10, 2018: Semergen
https://www.readbyqxmd.com/read/30314579/retrospectively-reported-childhood-adversity-is-associated-with-asthma-and-chronic-bronchitis-independent-of-mental-health
#5
Mashhood Ahmed Sheikh
Several researchers have raised the concern that the cross-sectional association of retrospectively reported childhood adversity with self-reported onset of asthma and chronic bronchitis in adulthood may be confounded, as well as mediated by an individual's mental health. The aim of this study was to assess the effect of retrospectively reported childhood adversity on self-reported onset of asthma and chronic bronchitis in adulthood, independent of potential confounding and mediating variables (including respondent's mental health)...
November 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/30298010/development-and-role-in-therapy-of-canakinumab-in-adult-onset-still-s-disease
#6
Paola Galozzi, Chiara Baggio, Sara Bindoli, Francesca Oliviero, Paolo Sfriso
Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown etiology typically characterized by episodes of spiking fever, evanescent rash, arthralgia, leukocytosis, and hyperferritinemia. The pivotal role of interleukin (IL)-1 and other pro-inflammatory cytokines gives rise to the development of new targeted therapies. Currently, AOSD patients can benefit from efficient and well tolerated biologic agents, such as IL-1, IL-6, and tumour necrosis factor (TNF)-α antagonists. Canakinumab, a human monoclonal anti-IL-1β antibody, is indicated for the treatment of different autoinflammatory syndromes in adults, adolescents, and children and it has recently been approved for AOSD treatment...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30295095/pathogenesis-of-adult-onset-still-s-disease-current-understanding-and-new-insights
#7
Piero Ruscitti, Roberto Giacomelli
Adult-onset Still's disease (AOSD) is a rare inflammatory disorder typically characterized by fever, arthritis, and hyperferritinemia. Concerning AOSD pathogenesis, it is categorized as a multigenic autoinflammatory disease, at the 'crossroads' of autoinflammatory and autoimmune diseases, because of the involvement of both arms of immune system. Areas covered: This work is conceived as narrative overview assessing the pathogenesis of AOSD. We performed a narrative synthesis of published information, summarizing the contents of previous studies and providing a possible rationale for future researches...
October 8, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/30279267/tocilizumab-in-patients-with-adult-onset-still-s-disease-refractory-to-glucocorticoid-treatment-a-randomised-double-blind-placebo-controlled-phase-iii-trial
#8
Yuko Kaneko, Hideto Kameda, Kei Ikeda, Tomonoti Ishii, Kosaku Murakami, Hyota Takamatsu, Yoshiya Tanaka, Takayuki Abe, Tsutomu Takeuchi
OBJECTIVE: To evaluate the efficacy and safety of tocilizumab, an interleukin-6 receptor antibody, in patients with adult-onset Still's disease. METHODS: In this double-blind, randomised, placebo-controlled phase III trial, 27 patients with adult-onset Still's disease refractory to glucocorticoids were randomised to tocilizumab at a dose of 8 mg/kg or placebo given intravenously every 2 weeks during the 12-week, double-blind phase. Patients received open-label tocilizumab for 40 weeks subsequently...
October 2, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30268135/improvement-of-survival-rates-in-the-last-decade-in-thai-childhood-onset-systemic-lupus-erythematosus
#9
Pondtip Jongvilaikasem, Edward B McNeil, Pornsak Dissaneewate, Prayong Vachvanichsanong
BACKGROUND: Morbidity and mortality in childhood onset systemic lupus erythematosus (SLE) is more severe than adult onset SLE. Long-term follow up is needed to determine the prognosis. The objectives of this study are to describe the mortality of childhood SLE in a single tertiary care centre over three decades, compare trends in survival over time, and determine predictors for survival. METHODS: We retrospectively reviewed the medical records of children aged < 18 years who were diagnosed with SLE at the Department of Pediatrics, Songklanagarind Hospital, Thailand, from 1985 to 2016...
September 29, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/30254808/adult-onset-still-s-disease-in-a-female-patient-with-schizophrenia-a-case-report-and-literature-review
#10
Nasim Golchin, Mohaddeseh Sharifzadeh, Mina Fransawy Alkomos, Issac Sachmechi
Adult-onset Still's disease (AOSD) is a rare diagnosis. In small percentage of cases, AOSD is associated with other autoimmune diseases including schizophrenia. Despite the lack of sufficient studies, both conditions may share similar autoimmune pathogenic pathways. Herein we describe a 36-year-old woman with the past medical history of schizophrenia who presented with spiking fevers, arthralgia, evanescent rash and pleural chest pain. She reported developing these symptoms a while after poor compliance with her antipsychotic medication...
July 21, 2018: Curēus
https://www.readbyqxmd.com/read/30252172/increased-risk-for-new-onset-hypertension-in-midlife-male-snorers-the-14-year-follow-up-study
#11
Seung Ku Lee, Kanghoon Choi, Yoon Hee Chang, Jinyoung Kim, Chol Shin
While the association between sleep-related breathing disorders such as snoring and hypertension has been well established, it still remains unclear whether the association differs by age and gender. Therefore, in this 14-year follow-up study, we examined the independent association between self-reported snoring and the incidence of hypertension by gender and age groups in a large cohort of Korean adults. A total of 4,954 adults, aged 40-69 years, free of hypertension at baseline were enrolled. Participants were divided into three groups based on a self-reported snoring frequency: never; occasional (snoring <4 nights per week); and habitual snorer (snoring ≥4 nights)...
September 3, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/30250265/animal-models-of-neurodegenerative-diseases
#12
REVIEW
Ted M Dawson, Todd E Golde, Clotilde Lagier-Tourenne
Animal models of adult-onset neurodegenerative diseases have enhanced the understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Nevertheless, our understanding of these disorders and the development of mechanistically designed therapeutics can still benefit from more rigorous use of the models and from generation of animals that more faithfully recapitulate human disease. Here we review the current state of rodent models for Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis...
October 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/30249729/expand-the-differential%C3%A2-think-beyond-rheumatoid-arthritis
#13
Cody Schwartz, Altelisha Taylor, Zareen Zaidi
A 31-year-old male patient with severe, migratory arthralgias presented to our academic medical centre after being erroneously diagnosed and treated for rheumatoid arthritis for over 1 year. Multiple immunomodulatory therapies for rheumatoid arthritis were attempted with no relief of symptoms. Eventually, the pain was so bothersome that the patient became bedridden for 1 month prior to presenting to our facility. Our assessment revealed that the patient met the diagnostic criteria, known as the Yamaguchi criteria, needed to diagnose adult-onset Still's disease...
September 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30249709/role-of-acetyltransferase-pg1842-in-gingipain-biogenesis-in-porphyromonas-gingivalis
#14
Arunima Mishra, Francis Roy, Yuetan Dou, Kangling Zhang, Hui Tang, Hansel M Fletcher
Porphyromonas gingivalis , the major etiologic agent in adult periodontitis, produces large amounts of proteases that are important for its survival and pathogenesis. Activation/maturation of gingipains, a major protease, in P. gingivalis involves a complex network of processes which are not yet fully understood. VimA, a putative acetyltransferase and virulence modulating protein in P. gingivalis , is known to be involved in gingipains biogenesis. P. gingivalis FLL92, a vimA- defective isogenic mutant ( vimA :: ermF-ermAM ) showed late onset gingipain activity at stationary phase indicating the likelihood of a complimentary functional VimA homolog in that growth phase...
September 24, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/30245097/cytokine-levels-in-persistent-skin-lesions-of-adult-onset-still-disease
#15
Elina Zuelgaray, Maxime Battistella, Marie-Dominique Vignon-Pennamen, Sophie Ly Ka So, Michel Rybojad, Antoine Petit, Florence Cordoliani, David Boccara, Maurice Mimoun, Dan Lipsker, François Chasset, Armand Bensussan, Martine Bagot, Jean-David Bouaziz, Laurence Michel
No abstract text is available yet for this article.
September 20, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/30239973/successful-treatment-with-anakinra-of-an-hiv-associated-immune-reconstitution-inflammatory-syndrome-mimicking-adult-onset-still-s-disease
#16
Lea Bottlaender, Pascal Sève, Laurent Cotte, Mathieu Gerfaud-Valentin, Yvan Jamilloux
No abstract text is available yet for this article.
September 19, 2018: Rheumatology
https://www.readbyqxmd.com/read/30235174/relationship-between-early-psychotraumatisation-with-the-onset-and-the-course-of-psychotic-disorders
#17
Miro Klarić, Sanjin Lovrić
Connections between specific types of altered brain functioning and some mental disorders are still not fully clarified. However, there is a large number of evidence that indicates mental disorders are results of complex interactions of biological and environmental factors. When it comes to environmental factors, the main focus in the scientific literature has been particularly focused on early psychotraumatisation. Early psychotraumatisation is a multi-layered construct that essentially involves sexual, emotional and psychical neglect in childhood and emotional and psychical negligence, with about one-fourth of children experience a traumatic event before the age of 18...
September 2018: Psychiatria Danubina
https://www.readbyqxmd.com/read/30225546/differentiating-disease-flare-from-infection-a-common-problem-in-rheumatology-do-18f-fdg-pet-ct-scans-and-novel-biomarkers-hold-the-answer
#18
REVIEW
Elizabeth Mabey, Andrew Rutherford, James Galloway
PURPOSE OF REVIEW: Fever is common within rheumatology but it is often challenging to identify its source. To do so correctly is paramount in patients with an underlying inflammatory condition receiving immunosuppressive therapy. This review article looks at the available evidence and merits of both 18F-fluoro-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans and new proposed biomarkers in determining the cause of fever within rheumatology. RECENT FINDINGS: 18F-FDG PET/CT scans are already an established tool in the detection and diagnosis of malignancy and are emerging for use in fever of unknown origin...
September 17, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/30224079/neutrophilic-urticarial-dermatosis-a-review
#19
L Gusdorf, D Lipsker
Neutrophilic urticarial dermatosis (NUD) is a rare form of dermatosis. In clinical terms, it consists of a chronic or recurrent eruption comprising slightly elevated, pink to reddish plaques or macules. The elementary lesion lasts 24 to 48hours and resolves without leaving any residual pigmentation. Extra-cutaneous signs are common, particularly fever or arthralgia. At histopathology, the dermis contains dense neutrophilic interstitial infiltrate with leukocytoclasis, but without fibrinoid necrosis of vessel walls...
September 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/30218025/mechanisms-biomarkers-and-targets-for-adult-onset-still-s-disease
#20
REVIEW
Eugen Feist, Stéphane Mitrovic, Bruno Fautrel
Adult-onset Still's disease (AoSD) is a rare but clinically well-known, polygenic, systemic autoinflammatory disease. Owing to its sporadic appearance in all adult age groups with potentially severe inflammatory onset accompanied by a broad spectrum of disease manifestation and complications, AoSD is an unsolved challenge for clinicians with limited therapeutic options. This Review provides a comprehensive insight into the complex and heterogeneous nature of AoSD, describing biomarkers of the disease and its progression and the cytokine signalling pathways that contribute to disease...
October 2018: Nature Reviews. Rheumatology
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