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Agnieszka J Szczepek, Gunnar P H Dietz, Uta Reich, Olga Hegend, Heidi Olze, Birgit Mazurek
Many aspects of stress-induced physiological and psychological effects have been characterized in people and animals. However, stress effects on the auditory system are less explored and their mechanisms are not well-understood, in spite of its relevance for a variety of diseases, including tinnitus. To expedite further research of stress-induced changes in the auditory system, here we compare the reactions to stress among Wistar and Lewis rats. The animals were stressed for 24 h, and subsequently we tested the functionality of the outer hair cells (OHCs) using distortion product otoacoustic emissions (DPOAEs) and auditory neurons using evoked auditory brainstem responses (ABR)...
2018: Frontiers in Neuroscience
Snezana A Filipović, Mark P Haggard, Helen Spencer, Goran Trajković
In children with normal cochlear acuity, middle ear fluid often abolishes otoacoustic emissions (OAEs), and negative middle ear pressure (NMEP) reduces them. No convincing evidence of beneficial pressure compensation on distortion product OAE (DPOAE) has yet been presented. Two studies aimed to document effects of NMEP on transient OAE (TEOAE) and DPOAE. In Study 1, TEOAE and DPOAE pass/fail responses were analyzed before and after pressure compensation in 50 consecutive qualifying referrals having NMEP from -100 to -299 daPa...
January 2018: Trends in Hearing
Christopher Spankovich, Glenis R Long, Linda J Hood
BACKGROUND: The relationship between type-1 diabetes mellitus (DM) and cochlear dysfunction remains inconclusive. PURPOSE: The purpose of this study was to examine otoacoustic emissions (OAEs) in normal-hearing young adults with type-1 DM as compared with matched controls and identify potential covariates influencing OAE findings. RESEARCH DESIGN: Cross-sectional study. STUDY SAMPLE: N = 40 young adults aged 18-28 years including individuals with type-1 DM (n = 20) and age-gender matched controls (n = 20) with normal hearing sensitivity...
September 25, 2018: Journal of the American Academy of Audiology
João Soares Felício, Lilian de Souza d'Albuquerque Silva, Carlliane Lima E Lins Pinto Martins, João Felício Abrahão Neto, Manuela Nascimento de Lemos, Fabrício de Souza Resende, Wanderson Maia da Silva, Angélica Leite de Alcântara, Maria Clara Neres Iunes de Oliveira, Norberto Jorge Kzan de Souza Neto, Isabela Imbelloni Farias de Franco, Nathalie Abdallah Zahalan, Luísa Correa Janaú, Ana Carolina Contente Braga de Souza, Flavia Marques Santos, Natércia Neves Marques de Queiroz, Neyla Arroyo Lara Mourão, Márcia Costa Dos Santos, Karem Miléo Felício, Franciane Trindade Cunha de Melo
Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoacoustic emissions (OAEs) is useful to identify subclinical cochlear dysfunction. Therefore, the aim of this study was to evaluate the association between abnormal OAEs responses, diabetic kidney disease (DKD) and diabetic cardiac autonomic neuropathy (CAN). We performed a cross-sectional study with 37 type 1 DM patients without auditory symptoms, submitted to the study of Distortion Product Otoacoustic Emissions (DPOAEs) and screened for DKD and CAN...
2018: Diabetology & Metabolic Syndrome
Reza M Amanipour, Xiaoxia Zhu, Guillaume Duvey, Sylvain Celanire, Joseph P Walton, Robert D Frisina
Acoustic trauma can induce temporary or permanent noise-induced hearing loss (NIHL). Noise exposed animal models allow us to study the effects of various noise trauma insults on the cochlea and auditory pathways. Here we studied the short-term and long-term functional changes occurring in the auditory system following exposure to two different noise traumas. Several measures of hearing function known to change following noise exposure were examined: Temporary (TTS) and permanent (PTS) threshold shifts were measured using auditory brainstem responses (ABR), outer hair cell function was examined using distortion product otoacoustic emissions (DPOAEs), and auditory temporal processing was assessed using a gap-in-noise (GIN) ABR paradigm...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Stephen T Neely, Sara E Fultz, Judy G Kopun, Natalie M Lenzen, Daniel M Rasetshwane
OBJECTIVES: Cochlear reflectance (CR) is the cochlear contribution to ear-canal reflectance. CR is a type of otoacoustic emission (OAE) that is calculated as a transfer function between forward pressure and reflected pressure. The purpose of this study was to compare wideband CR to distortion-product (DP) OAEs in two ways: (1) in a clinical-screening paradigm where the task is to determine whether an ear is normal or has hearing loss and (2) in the prediction of audiometric thresholds...
November 5, 2018: Ear and Hearing
Steven C Marcrum, Thomas Steffens, Florian Zeman, Peter Kummer
Purpose: Distortion product otoacoustic emission (DPOAE) amplitude is sensitive to the primary tone level separation effective within the cochlea. Despite potential for middle ear sound transmission characteristics to affect this separation, no primary tone level optimization formula accounts for its influence. This study was conducted to determine if inclusion of ear- and frequency-specific immittance features improves primary tone level optimization formula performance beyond that achieved using a univariate, L2-based formula...
October 31, 2018: American Journal of Audiology
Amisha Kanji, Katijah Khoza-Shangase, Nomfundo Moroe
OBJECTIVE: To conduct a review of the most current research in objective measures used within newborn hearing screening protocols with the aim of exploring the actual protocols in terms of the types of measures used and their frequency of use within a protocol, as well as their outcomes in terms of sensitivity, specificity, false positives, and false negatives in different countries worldwide. METHODS: A systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis...
December 2018: International Journal of Pediatric Otorhinolaryngology
Naomi F Bramhall, Garnett P McMillan, Sharon G Kujawa, Dawn Konrad-Martin
Cochlear synaptopathy, the loss of synaptic connections between inner hair cells (IHCs) and auditory nerve fibers, has been documented in animal models of aging, noise, and ototoxic drug exposure, three common causes of acquired sensorineural hearing loss in humans. In each of these models, synaptopathy begins prior to changes in threshold sensitivity or loss of hair cells; thus, this underlying injury can be hidden behind a normal threshold audiogram. Since cochlear synaptic loss cannot be directly confirmed in living humans, non-invasive assays will be required for diagnosis...
December 2018: Hearing Research
Prashanth Prabhu, Akhila Chandrashekhar, Janani Cariappa, Nayanika Ghosh
Introduction  Individuals with blood group O are reported to have reduced otoacoustic emissions (OAEs) compared with individuals with different blood groups. Objective  The present study attempted to determine if the blood group has any effect on high-frequency auditory sensitivity using ultrahigh-frequency audiometry and ultrahigh-frequency distortion product otoacoustic emissions (DPOAEs). Methods  High-frequency thresholds and high-frequency DPOAEs were measured in 60 individuals with normal hearing and different blood groups...
October 2018: International Archives of Otorhinolaryngology
Daniel Kondziella, Anne Marie Jensen, Thomas Hjuler, Michael Bille, Jesper Kjaergaard
Background: Non-invasive, easy-to-use bedside tools to estimate prognosis in unresponsive patients with postanoxic brain injury are needed. We assessed the usefulness of otoacoustic emissions as outcome markers after cardiac arrest. Methods: Distortion product otoacoustic emissions (DPOAE) and transient evoked otoacoustic emissions (TEOAE) were measured in cardiac arrest patients whose prognosis was deemed to be poor following standard neurological assessment ( n = 10). Ten patients with myocardial infarction without prior loss of consciousness served as controls...
2018: Frontiers in Neurology
Gülin Gökçen Kesici, Fatma Ceyda Akın Öcal, Seren Gülşen Gürgen, Şaban Remzi Erdem, Ersin Öğüş, Hatice Seyra Erbek, Levent Naci Özlüoğlu
OBJECTIVE: To test the protective effect of metformin against noise-induced hearing loss. METHODS: 24 rats were included in the study. The first group was exposed to noise only, the second group took metformin, the third group was exposed to noise and took metformin, and the fourth group was neither exposed to noise nor took metformin as control group. After measurement of baseline DPOAE and ABR of rats, the metformin group and the metformin + noise group received 300 mg/kg/day metformin via gavage for 10 days...
December 2018: European Archives of Oto-rhino-laryngology
Reto Stump, Ivo Dobrev, Niklaus Krayenbühl, Rudolf Probst, Christof Röösli
BACKGROUND: Bone conduction (BC) is an alternative to air conduction (AC) for stimulation of the inner ear. Stimulation for BC can occur directly on the skull bone, on the skin covering the skull bone, or on soft tissue (i.e., eye, dura). All of these stimuli can elicit otoacoustic emissions (OAE). This study aims to compare OAEs generated by different combinations of stimuli in live humans, including direct stimulation of the intracranial contents via the dura, measured intraoperatively...
December 2018: Hearing Research
Sanem O Erkan, Birgül Tuhanioğlu, Seren G Gürgen, Talih Özdaş, Bora Taştekin, Aykut Pelit, Orhan Görgülü
OBJECTIVES/HYPOTHESIS: The aim of this study was to investigate changes in the cochlea and the potential dose-dependent effects of resveratrol (RSV) against diabetes mellitus (DM) ototoxicity. STUDY DESIGN: Animal model. METHODS: Twenty-four male Wistar albino rats were divided into four groups. Baseline distortion product otoacoustic emission (DPOAE) measurements were evaluated. Group I was the control group, group II was made diabetic with single-dose streptozotocin, and groups III and IV were rendered diabetic as group II and administered 10 and 20 mg RSV, respectively, intraperitoneally for 4 weeks...
October 3, 2018: Laryngoscope
D Vir, P Sharma, R Mahajan, S Dogra, J Bakshi, N K Panda
The inner ear can be the target of autoimmune attacks, and sensorineural hearing loss can occur as a complication in various non-organ-specific autoimmune diseases. The aim of this study was to compare cochlear functions and hearing evaluation in patients with psoriasis and controls. In total, 29 patients with psoriasis and 30 healthy controls (HCs) were included in the study. Pure-tone audiometry at 250, 500, 1000, 2000, 4000, 8000, 10 000, 12 000, 14 000 and 16 000 Hz was performed for patients as HCs, as were immittance measures including tympanometry, acoustic reflex and otoacoustic emission testing...
October 2, 2018: Clinical and Experimental Dermatology
Allison R Loiselle, Emile de Kleine, Pim van Dijk, Nomdo M Jansonius
The theory that glaucoma patients have a lower intracranial pressure (ICP) than healthy subjects is a controversial one. The aim of this study was to assess ICP noninvasively by determining the relationship between distortion product otoacoustic emission (DPOAE) phase and body position and to compare this relationship between patients with primary open angle glaucoma (POAG), patients with normal tension glaucoma (NTG), and controls. The relationship was also calibrated using published data regarding invasive measurements of ICP versus body position...
2018: PloS One
Louise J Dickinson, Moea Nimmo, Randall P Morton, Suzanne C Purdy
BACKGROUND: Seven hundred children were recalled for hearing screening at age 2-3 years due to a problem with their newborn hearing screen. They had all been well babies with no identified risk factors for hearing loss and hence were not scheduled for targeted follow-up to retest hearing. METHODS: There were 485 children (69%) that attended the recall. The average age was 36 months (SD 3.7). Family ethnicity was Pacific Island (36%), Asian (26%), NZ European (13%), and Māori (11%), and there was a high level of deprivation in the study population...
November 2018: International Journal of Pediatric Otorhinolaryngology
Krystin Carlson, Jochen Schacht, Richard L Neitzel
Exposure to heavy metals may lead to hearing impairment. However, experimental studies have not explored this issue with and without noise exposure in mature animals with environmentally relevant doses. The aim of this study was to investigate ototoxicity produced by lead (Pb) and cadmium (Cd) and noise, singly and in combination, in the adult CBA/CaJ mouse. Metals were delivered via drinking water (0.03 mM, 1 mM, and 3 mM Pb; or 30, 100, and 300 μM Cd) for 12 weeks, resulting in environmentally- and occupationally relevant mean (± standard deviations) blood levels of Pb (2...
September 21, 2018: Journal of Toxicology and Environmental Health. Part A
Emmy Pramesthi Dyah Soelistijani, Nyilo Purnami, M S Wiyadi
Tinnitus is the perception of hearing the sound without any sound stimulus. It is a symptom of abnormality in a form of conductive disorder when it comes from the outer ear canal and middle ear. A tinnitus complaint has a normal hearing threshold but it has been not fully recognized its causes. Thus, an objective evaluation is needed to locate the abnormality by using OAE and BERA test. To analyze the association of TEOAE, DPOAE, and BERA to locate cochlear and retrocochlear disorders in tinnitus patients with normal hearing threshold...
September 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
Seyede Faranak Emami, Nasrin Gohari, Hossein Ramezani, Mariam Borzouei
Introduction: Estrogen has a protective role on auditory function. It may have an excitatory action on auditory nerve fibers and can have a neuroprotective effect. Progesterone has a mainly inhibitory action on the central nervous system, which may balance the mainly excitatory action of estrogen. Objective: To determine changes in hearing performance with pure tone audiometry (PTA), tympanometry, distortion product otoacoustic emissions (DPOAEs), and auditory brainstem responses (ABR) as hormonal changes occur from follicular to luteal phase...
2018: International Journal of Otolaryngology
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