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Arturo Moleti, Renata Sisto, Christopher A Shera
The DPOAE response consists of the linear superposition of two components, a nonlinear distortion component generated in the overlap region, and a reflection component generated by roughness in the DP resonant region. Due to approximate scaling symmetry, the DPOAE distortion component has approximately constant phase. As the reflection component may be considered as a SFOAE generated by the forward DP traveling wave, it has rapidly rotating phase, relative to that of its source, which is also equal to the phase of the DPOAE distortion component...
May 31, 2018: AIP Conference Proceedings
Anders T Christensen, Carolina Abdala, Christopher A Shera
Distortion-product otoacoustic emission (DPOAE) phase is shaped by interaction between the evoking stimulus waves. Near-invariant at high frequencies, DPOAE phase-vs-frequency functions measured at fixed ratios bend into sloping functions at low frequencies. The different phase behaviors observed suggest that the mechanics underlying the generation of OAEs differ in the halves of the cochlea. To map out the phenomenological extent of low-to-mid frequency phase bends, this study recorded DPOAE responses from 20 normal-hearing human adult ears for a wide range of stimulus frequencies, f 1 and f 2 , where f 2 frequency sweeps from 0...
May 31, 2018: AIP Conference Proceedings
Shadman Nemati, Rasool Hassanzadeh, Mojtaba Mehrdad, Sahar Sajedi Kia
Introduction: It seems that diabetes mellitus (DM) can affect the auditory system due to neuropathy, micro-vascular complications, and hearing cell damage during hyperglycemic states. In the current study, we aimed to compare hearing status in patients with type 2 DM (T2DM) according to their blood-sugar control status. Materials and Methods: This cross-sectional study was carried out in 104 patients with T2DM attending the diabetic clinics of Guilan University of Medical Sciences within a period of 1 year (2014-2015)...
July 2018: Iranian Journal of Otorhinolaryngology
Johnnie K Bass, Jie Huang, Chia-Ho Hua, Shaum P Bhagat, Lisa Lucks Mendel, Arzu Onar-Thomas, Daniel J Indelicato, Thomas E Merchant
Purpose: Compared to photon-based radiotherapy, protons deliver less radiation to healthy tissue resulting in the potential reduction of late complications such as sensorineural hearing loss (SNHL). We report early auditory outcomes in children treated with proton radiotherapy (PRT) for craniopharyngioma. Method: Conventional frequency (CF = 0.25-8.0 kHz) audiometry, extended high-frequency (EHF = 9.0-16.0 kHz) audiometry, distortion product otoacoustic emission (DPOAE) testing, and speech-in-noise (SIN) assessments were prospectively and longitudinally conducted on 74 children with a median of 2 post-PRT evaluations (range, 1-5) per patient...
August 1, 2018: American Journal of Audiology
Jae Hyun Jung, Miryeong Kim, Seung Jae Lee, Eunsang Lee, Se A Lee, Jong Dae Lee, Ji Ho Choi, Bo Gyung Kim
OBJECTIVES: To our knowledge, the influence of sleep deprivation on hearing levels has yet to be assessed in animals. Therefore, we evaluated whether auditory function was affected by sleep deprivation in rats. METHODS: Male Wistar rats (aged 9 weeks, weighing 300-400 g) were used for the study and were randomly assigned to a control (n = 15) or sleep deprivation group (n = 12). Hearing levels were evaluated at baseline and 9 days after sleep deprivation using auditory evoked brainstem responses (ABRs) and distortion product otoacoustic emission (DPOAE) measurements...
September 2018: International Journal of Pediatric Otorhinolaryngology
Lucretia Petersen, Wayne J Wilson, Harsha Kathard
 Although distortion product otoacoustic emissions (DPOAEs) are useful in evaluating cochlear outer hair cell function, determining the optimal stimulus parameters could result in a more reliable, sensitive and specific diagnostic tool across the range of DPOAE applications. Objectives: To identify which stimulus parameters warrant further investigation for eliciting the largest and most reliable DPOAEs in adult humans. Method: A single group, repeated measures design involving a convenience sample of 20 normal-hearing participants between 19 and 24 years of age...
July 16, 2018: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
Murat Dogan, Mustafa Sahin, Nesibe Cetin, Mustafa Yilmaz, Buket Demirci
PURPOSE: To evaluate prestin as a biomarker for the identification of early ototoxicity. MATERIALS AND METHODS: Rats (n = 47) were randomly assigned to five groups: low-dose (LAG) or high-dose (HAG) amikacin (200 and 600 mg/kg/day, respectively, for 10 days), low-dose (LCIS)or high-dose (HCIS) cisplatin (single doses of 5 and 15 mg/kg, respectively, for 3 days), and control (n = 8). At the end of the experiment, measurement of distortion product-evoked otoacoustic emissions (DPOAE) were performed to evaluate hearing, then blood samples and both ear tissues were collected under anesthesia...
July 12, 2018: American Journal of Otolaryngology
Reham F Zittoon, Yasser T Madian, Diaa Eldeen M Alhennawi, Hany S Nadeem
To evaluate the effect of peginterferon α-2b on guinea pigs' hearing and its cochlea, and to determine whether these effects are permanent or reversible. This study is an experimental animal study done on the organs of Corti of 30 guinea pigs after a peginterferon α-2b injection course. The cochleae of guinea pigs were extracted and examined by scanning electron microscopy for the right side and immunohistochemistry for the left side. All guinea pigs were subjected to pinna reflex, otological examination, and distortion product otoacoustic emission (DPOAE) both before and after the receiving of interferon (IFN)...
July 2018: Journal of Interferon & Cytokine Research
Yojana Sharma Hansashree, Sushen H Bhatt, Somashekhar Nimbalkar, Girish Mishra
OBJECTIVE: The reasons of failure to follow-up for the Universal Neonatal Hearing Screening (UNHS) program were delineated. METHODS: Review of case records for data related to follow-up of neonates who underwent the UNHS between February 2012 - January 2015. RESULTS: 2534 neonates underwent primary screening with Distortion Product Oto-acoustic Emission (DPOAE). 14 (26.9%) were lost to follow-up between the first and second DPOAE screenings...
June 15, 2018: Indian Pediatrics
Muhammed Nabeel Latheef, P Karthikeyan, V Nirmal Coumare
To evaluate hearing of the contralateral normal ear before and after mastoidectomy in a longitudinal manner and to assess whether the hearing loss is transient or permanent and to find out the duration of temporary hearing loss. This was a clinical longitudinal observational study involving 50 patients with unilateral chronic suppurative otitis media requiring mastoidectomy operation over a period of 18 months after satisfying the inclusion criteria. During the part of the mastoidectomy surgery involving drilling of the mastoid bone, noise levels were recorded at multiple points in the surgery using a digital sound level meter...
June 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
Carolina Abdala, Amanda J Ortmann, Christopher A Shera
Previous research on distortion product otoacoustic emission (DPOAE) components has hinted at possible differences in the effect of aging on the two basic types of OAEs: those generated by a reflection mechanism in the cochlea and those created by nonlinear distortion (Abdala and Dhar in J Assoc Res Otolaryngol 13:403-421, 2012). This initial work led to the hypothesis that micromechanical irregularity ("roughness") increases in the aging cochlea, perhaps as the result of natural tissue degradation...
July 2, 2018: Journal of the Association for Research in Otolaryngology: JARO
M Riga, A Komis, P Maragoudakis, G Korres, E Ferekidis, V Danielides
Accumulating evidence seems to support an association between tinnitus and medial olivocochlear bundle (MOCB) dysfunction. Most studies use patient/control comparisons to support this correlation. The aim of this study was to investigate the hypothesis in a substantially different way and evaluate the roles of gender, age, frequency and tinnitus bilaterality as possible confounding factors. The population consisted of 78 normal hearing patients with chronic tinnitus, 28 normal hearing controls, 19 presbycousic tinnitus patients and 13 presbycousic controls (n = 276 ears)...
April 2018: Acta Otorhinolaryngologica Italica
Nikki A Go, Greta C Stamper, Tiffany A Johnson
OBJECTIVES: This study aims to determine the impact of controlling cochlear-source mechanism on the accuracy with which auditory status is identified using otoacoustic emissions (OAEs) in two groups of subjects with normal hearing (NH) and subjects with mild to moderate hearing loss. DESIGN: Data were collected from 212 subjects with NH and with mild to moderate hearing loss who fell into two categories based on a distortion product OAE (DPOAE) screening protocol: the uncertain-identification group (where errors were likely) and the certain-identification group (where errors were unlikely)...
June 26, 2018: Ear and Hearing
Renata Sisto, Uzma Shaheen Wilson, Sumitrajit Dhar, Arturo Moleti
When measured as a function of primary frequency ratio r = f2 /f1 , using a constant f2 , distortion product otoacoustic emission (DPOAE) response demonstrates a bandpass shape, previously interpreted as the evidence for a cochlear "second filter." In this study, an alternate, interference-based explanation, previously advanced in variants, is forwarded on the basis of experimental data along with numerical and analytical solutions of nonlinear and linear cochlear models. The decrease of the DPOAE response with increasing and decreasing ratios is explained by a diminishing "overlap" generation region and the onset of negative interference among wavelets of different phase, respectively...
June 26, 2018: Journal of the Association for Research in Otolaryngology: JARO
Rachael R Baiduc, Sumitrajit Dhar
Purpose: Distortion product otoacoustic emissions (DPOAEs) are a by-product of active cochlear processes that lead to the compressive nonlinearity of healthy ears. The most commonly studied emission is at the frequency 2f1-f2, but there has been recent interest in using the quadratic distortion product at the frequency f2-f1 to detect cochleopathies including endolymphatic hydrops. Before the DPOAE at f2-f1 can be applied clinically in any capacity, optimal stimulus parameters for its elicitation must be established...
July 13, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
Ying Cheng, Masako Nakamura, Tatsuo Matsunaga, Kimitaka Kaga
Objective: Congenital auditory neuropathy (AN) affects hearing and speech development. The degree of hearing difficulty in congenital AN varies as a function of pathology at the inner ear hair cell (IHC) synapses or the auditory nerve. We report a case of a Chinese girl with AN revealed by OTOF (otoferlin) gene mutation analysis who had only a mild hearing loss. Patient: A 13-year-old Chinese girl was diagnosed as having congenital AN on the basis of OTOF gene mutation analysis...
December 2017: Journal of Otology
Eman Abd Elmohsin Dawoud, Elshahat Ibrahem Ismail, Soheir Abdel-Gaber Eltoukhy, Ayman El-Saeed El-Sharabasy
Objectives: To evaluate audiological and vestibular functions via basic audiological evaluation, otoacoustic emissions and videonystagmography (VNG) in vitiligo patients. Material and methods: 30 vitiligo patients (8 acrofacial and 22 mixed types) as the study group and 30 normal healthy adults as the control group were included in the study. All participants were submitted to basic audiological evaluation, transient and distortion product otoacoustic emmisions (TEOAEs and DPOAEs), vestibular assessment including history taking, office tests and videonystagmography (VNG) and dermatological assessment to determine type, percent of body surface area involvement and duration of vitiligo...
September 2017: Journal of Otology
Adrian L James, Peter R Dixon, Robert V Harrison
BACKGROUND: Cochlear nerve aplasia (CNA) may present with features of auditory neuropathy spectrum disorder (ANSD), having detectable otoacoustic emissions (OAE) but profound hearing loss. We propose that some children with CNA have a distinct form of afferent ANSD in which efferent cochlear nerve function can be detected using contralateral suppression of OAE. METHODS: Children were prospectively enrolled with MRI and auditory brainstem response evidence of unilateral CNA, a normal contralateral ear, and detectable OAE bilaterally...
June 22, 2018: Audiology & Neuro-otology
Amisha Kanji, Katijah Khoza-Shangase
BACKGROUND: The ideal hearing screening measure is yet to be defined, with various newborn hearing screening protocols currently being recommended for different contexts. Such diverse recommendations call for further exploration and definition of feasible and context-specific protocols. PURPOSE: The aim of the study was to establish which combinations of audiological screening measures provide both true-positive (TP) and true-negative (TN) results for risk-based hearing screening, at and across time...
June 2018: Journal of the American Academy of Audiology
Jieying Li, Yan Chen, Shan Zeng, Chuijin Lai, Yanping Zhang, Liting Zhang, Yuxuan Shi, Tianyu Zhang, Huawei Li, Peidong Dai
Medial olivocochlear (MOC) efferent feedback is suggested to protect the ear from acoustic injury and to increase its ability to discriminate sounds against a noisy background. We investigated whether type II spiral ganglion neurons participate in the contralateral suppression of the MOC reflex. The application of ouabain to the round window of the mouse cochlea selectively induced the apoptosis of the type I spiral ganglion neurons, left the peripherin-immunopositive type II spiral ganglion neurons intact, and did not affect outer hairs, as evidenced by the maintenance of the distorted product otoacoustic emissions (DPOAEs)...
2018: Neural Plasticity
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