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Elizabeth J White, Gabriel Gyulay, Šárka Lhoták, Magdalena M Szewczyk, Taryne Chong, Mark T Fuller, Omid Dadoo, Alison E Fox-Robichaud, Richard C Austin, Bernardo Trigatti, Suleiman A Igdoura
Atherosclerosis is a complex disease that involves alterations in lipoprotein metabolism and inflammation. Protein and lipid glycosylation events, such as sialylation, contribute to the development of atherosclerosis and are regulated by specific glycosidases, including sialidases. To evaluate the effect of the sialidase neuraminidase 1 (NEU1) on atherogenesis, here we generated apolipoprotein E (ApoE)-deficient mice that express hypomorphic levels of NEU1 ( Neu1hypo Apoe-/- ). We found that the hypomorphic NEU1 expression in male Apoe-/- mice reduces serum levels of very-low-density lipoprotein (VLDL) and LDL cholesterol, diminishes infiltration of inflammatory cells into lesions, and decreases aortic sinus atherosclerosis...
August 10, 2018: Journal of Biological Chemistry
Catherine M Phillips, Nitin Shivappa, James R Hébert, Ivan J Perry
Accumulating evidence identifies diet and inflammation as potential mechanisms contributing to cardiometabolic risk. However, inconsistent reports regarding dietary inflammatory potential, biomarkers of cardiometabolic health and metabolic syndrome (MetS) risk exist. Our objective was to examine the relationships between a food frequency questionnaire (FFQ)-derived dietary inflammatory index (DII® ), biomarkers of lipoprotein metabolism, inflammation and glucose homeostasis and MetS risk in a cross-sectional sample of 1992 adults...
August 8, 2018: Nutrients
Richard F Spaide, Lawrence A Yannuzzi, Peter M Maloca
PURPOSE: To investigate the deep retinal vascular changes potentially present in macular telangiectasis Type 2 (MacTel 2) with projection resolved optical coherence tomography angiography including volume rendering. METHODS: Retrospective consecutive evaluation of patients with MacTel 2 in a community-based retinal referral practice with a comprehensive ophthalmologic examination to include optical coherence tomography and projection-resolved optical coherence tomography angiography with volume rendering...
August 8, 2018: Retina
Nathaly Torres-Castillo, Jorge Antonio Silva-Gómez, Wendy Campos-Perez, Elisa Barron-Cabrera, Ivan Hernandez-Cañaveral, Mary Garcia-Cazarin, Yolanda Marquez-Sandoval, Karina Gonzalez-Becerra, Carlos Barron-Gallardo, Erika Martinez-Lopez
OBJECTIVE: The aim of this study was to analyze dietary ω-6:ω-3 polyunsaturated fatty acid (PUFA) ratio and its association with adiposity and serum adiponectin levels in a Mexican population. METHODS: In this cross-sectional study, individuals with a BMI ≥ 18.5 kg/m2, were classified using four methods to measure adiposity. Parameters of body composition were measured by InBody 3.0. Diet intake was evaluated prospectively using a 3-day written food record. Serum high-molecular weight adiponectin isoform was measured using an ELISA assay...
August 10, 2018: Obesity Facts
Joselyn Allen, Jingtao Zhang, Michael D Quickel, Mary Kennett, Andrew D Patterson, Pamela A Hankey-Giblin
Liver fibrosis is commonly observed in the terminal stages of non-alcoholic steatohepatitis (NASH) and with no specific and effective anti-fibrotic therapies available, this disease is a major global health burden. The MSP/Ron receptor axis has been shown to have anti-inflammatory properties in a number of mouse models, due at least in part, to its ability to limit pro-inflammatory responses in tissue-resident macrophages and hepatocytes. In this study, we established the role of the Ron receptor in steatohepatitis-induced hepatic fibrosis using Ron ligand domain knockout mice on an apolipoprotein E knockout background (DKO)...
August 9, 2018: Journal of Proteome Research
Pankaj Hari, Priyanka Khandelwal, Amit Satpathy, Smriti Hari, Ranjeet Thergaonkar, R Lakshmy, Aditi Sinha, Arvind Bagga
BACKGROUND: Dyslipidemia is an important cardiovascular risk factor in steroid-resistant nephrotic syndrome (SRNS). Efficacy of statins for treatment of hyperlipidemia in children with SRNS is unclear. METHODS: This prospective, randomized, double-blind, placebo-controlled, parallel-group clinical trial enrolled 30 patients with SRNS, aged 5-18 years, with serum low-density lipoprotein cholesterol (LDL-C) levels between 130 and 300 mg/dl, to receive a fixed dose of atorvastatin (n = 15, 10 mg/d) or placebo (n = 15) by block randomization in a 1:1 ratio...
August 8, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Zhenhua Wu, Fan Yang, Shan Jiang, Xiaoyu Sun, Jialin Xu
Endoplasmic reticulum (ER) stress is highly associated with liver steatosis. B-cell receptor-associated protein 31 (BAP31) has been reported to be involved in ER homeostasis, and plays key roles in hepatic lipid metabolism in high-fat diet-induced obese mice. However, whether BAP31 modulates hepatic lipid metabolism via regulating ER stress is still uncertain. In this study, wild-type and liver-specific BAP31-depleted mice were administrated with ER stress activator of Tunicamycin, the markers of ER stress, liver steatosis, and the underlying molecular mechanisms were determined...
August 4, 2018: International Journal of Molecular Sciences
Supriya Mishra, Vani Gupta, Sameeksha Mishra, Himani Kulshrestha, Sandeep Kumar, Vandana Gupta, Rekha Sachan, Abbas Ali Mahdi
BACKGROUND: Plasma concentrations of Acylation stimulating protein (ASP) and adiponectin are associated with body weight and energy homeostasis. The purpose of this study is to describe the potential role of acylation stimulating protein and adiponectin with metabolic risk marker in North Indian obese women. METHODS: This is a case control study. Total 520 women were recruited for the study n = 260 women with obesity (BMI>30) study group and n = 260 women without obesity (BMI<25) control group...
July 30, 2018: Diabetes & Metabolic Syndrome
Norihiro Imai, David E Cohen
Nonalcoholic fatty liver disease (NAFLD) is characterized by the hepatic accumulation of excess fatty acids in the form of triglycerides. Normally, the steady state concentration of triglycerides in the liver is low. This is because the accrual of fatty acids due to uptake from the plasma and de novo lipogenesis is balanced by ß-oxidation within liver mitochondria and by secretion into plasma as very low density lipoprotein (VLDL) triglycerides. In the setting of insulin resistance, increased rates of lipolysis within white adipose tissue lead to elevated concentrations of plasma fatty acids and increased rates of uptake into the liver...
August 3, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Rineke Steenbergen, Martin Oti, Rob Ter Horst, Wilson Tat, Chris Neufeldt, Alexandr Belovodskiy, Tiing Tiing Chua, Woo Jung Cho, Michael Joyce, Bas E Dutilh, D Lorne Tyrrell
Tissue culture medium routinely contains fetal bovine serum (FBS). Here we show that culturing human hepatoma cells in their native, adult serum (human serum, HS) results in the restoration of key morphological and metabolic features of normal liver cells. When moved to HS, these cells show differential transcription of 22-32% of the genes, stop proliferating, and assume a hepatocyte-like morphology. Metabolic analysis shows that the Warburg-like metabolic profile, typical for FBS-cultured cells, is replaced by a diverse metabolic profile consistent with in vivo hepatocytes, including the formation of large lipid and glycogen stores, increased glycogenesis, increased beta-oxidation and ketogenesis, and decreased glycolysis...
August 3, 2018: Scientific Reports
Niina Matikainen, Sanni Söderlund, Elias Björnson, Kirsi Pietiläinen, Antti Hakkarainen, Nina Lundbom, Marja-Riitta Taskinen, Jan Borén
AIMS/HYPOTHESIS: Subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) exhibit considerable residual risk for cardiovascular disease (CVD). There is therefore increasing interest in targeting postprandial lipid metabolism and remnant cholesterol. Treatment with the glucagon-like peptide 1 (GLP-1) analogue liraglutide reduces CVD risk by partly unexplained mechanisms. Here we investigated the effects of liraglutide intervention on ectopic fat depots, hepatic lipogenesis and fat oxidation, postprandial lipid metabolism and glycaemia in humans with type 2 diabetes...
August 2, 2018: Diabetes, Obesity & Metabolism
Deotima Sarkar, Arijit Chakraborty, Adipa Saha, Amar K Chandra
Background Iodine is a nonpareil constituent of thyroid hormones (THs) and a prime regulator of thyroid gland functioning. Although essential at recommended levels for the prevention of iodine deficiency disorders (IDDs), exposure to excess iodine reportedly causes hypothyroidism, hyperthyroidism, and several other emerging deleterious impacts. The objective of the present study is to explore the influence of excess iodide exposure on carbohydrate and lipid metabolism along with the histoarchitecture of certain associated organs such as the pancreas, liver, kidney, and skeletal and cardiac muscle because information on those aspects was found to be scanty...
August 1, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Lívia Geraldi Ferreira, Mariangela Endrighi, Karen Guttenkunst Lisenko, Maiara Rodrigues Duarte de Oliveira, Mateus Resende Damasceno, Jelieny Aparecida Claudino, Pamella Godinho Gutierres, Ana Paula Peconick, Flávia Maria de Oliveira Borges Saad, Márcio Gilberto Zangeronimo
The aim of this study was to evaluate the effects of oat beta-glucan supplementation on metabolic, physiological, immunological and nutritional variables in adult dogs. Fourteen dogs were fed a control diet or a diet supplemented with 1% beta-glucan during 71 days. Serum concentrations of glucose, total cholesterol and lipoprotein fractions, as well as plasma concentrations of peptide YY and ghrelin, were determined. In addition, coefficient of total tract apparent macronutrient digestibility (CTTAD), food intake and fecal output, score, and pH were evaluated...
2018: PloS One
Fariba Raygan, Vahidreza Ostadmohammadi, Zatollah Asemi
BACKGROUND AND AIMS: The objective of this investigation was to assess the effects of probiotic and selenium co-supplementation on indicators of mental health and metabolic profiles in diabetic people with coronary heart disease (CHD). METHODS: This randomized, double-blind, placebo-controlled trial was conducted among 54 diabetic people with CHD. Patients were randomly allocated into two groups to receive either 200 μg/day selenium plus 8 × 109  CFU/day probiotic (n = 27) or placebo (n = 27) for 12 weeks...
July 21, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Toshiyuki Watanabe, Toshirou Nema, Nobuyuki Hiruta, Takeyoshi Murano, Wolfgang J Schneider, Hideaki Bujo
BACKGROUND: The significance of Lp8, that is, abnormal lipoprotein(s) detected in fraction 8 by combined high-performance liquid chromatography/gel filtration column in patients with familial lecithin:cholesterol acyltransferase (LCAT) syndrome, in relation to the severity of LCAT deficiency has not been analyzed. OBJECTIVE: We have studied Lp8 in a patient with primary biliary cirrhosis. METHODS: Plasma lipoproteins were analyzed using high-performance liquid chromatography/gel filtration column in the course of treatment of a 47-year-old female patient with primary biliary cirrhosis...
June 22, 2018: Journal of Clinical Lipidology
Uswa Ahmad, Rabia Shabir Ahmad, Muhammad Sajid Arshad, Zarina Mushtaq, Syed Makhdoom Hussain, Aneela Hameed
BACKGROUND: Stevia (Stevia rebaudiana Bertoni) natural, safe, non-toxic, non-caloric sugar substitute is rich source of pharmacologically important glycoside stevioside that is linked to the pathology and complications of hyperlipidemia. METHODS: The present research was carried out to explore the anti-hyperlipidemic effect of aqueous extract of Stevia rebaudiana Bertoni leaves in albino rats. For this purpose, hyperlipidemia was induced by administration of Cholesterol (90% E, Appli Chem, Darmstadt, Germany) mixed at dose of 400 mg/kg body weight of rats in their daily routine feed...
July 27, 2018: Lipids in Health and Disease
Jennifer Taher, Christopher Baker, Danielle Alvares, Laraib Ijaz, Mahmood Hussain, Khosrow Adeli
Fundamental complications of insulin resistance and type 2 diabetes include the development of non-alcoholic fatty liver disease and an atherogenic fasting dyslipidemic profile, primarily due to increases in hepatic very low density lipoprotein (VLDL) production. Recently, central glucagon-like peptide-2 receptor (GLP2R) signalling has been implicated in regulating hepatic insulin sensitivity but its role in hepatic lipid and lipoprotein metabolism is unknown. In the current study, we investigated the role of GLP-2 in regulating hepatic lipid and lipoprotein metabolism in Syrian Golden hamsters, C57BL/6J mice, and Glp2r-/- mice on either a chow or a high fat diet (HFD)...
July 19, 2018: Endocrinology
Nii Ayite Aryee, Emmanuel Ayitey Tagoe, Victor Anomah, Benjamin Arko-Boham, David Nana Adjei
Introduction: There is limited data on the prevalence of thyroid dysfunction in Ghanaian individuals with chronic kidney disease (CKD). Studies exploring the effect of thyroid hormones on renal function decline are also scanty. Unrecognized thyroid dysfunction in CKD may increase the burden of adverse health outcomes. The aim of this study was to determine thyroid hormone status and lipid profiles in patients with CKD attending the Renal Unit of the Korle-Bu Teaching Hospital. Methods: 60 clinically euthyroid patients with CKD, and 65 clinically euthyroid subjects without CKD were recruited for this study...
2018: Pan African Medical Journal
J S Bhatti, R Vijayvergiya, B Singh, G K Bhatti
Genetic polymorphisms in glutathione S-transferase (GST) genes may modulate the risk of cardiovascular diseases. The objective of present study was to investigate the potential association between the polymorphisms of GSTM1/T1 and P1 genes and their influence on diverse clinical parameters and oxidative stress biomarkers in coronary artery disease (CAD) patients in Asian Indians. The present study includes 562 angiographically confirmed CAD patients and 564 healthy control subjects from the north Indian population...
July 24, 2018: Annals of Human Genetics
Marine Serveaux Dancer, Mathilde Di Filippo, Oriane Marmontel, René Valéro, Maria Del Carmen Piombo Rivarola, Noël Peretti, Cyrielle Caussy, Michel Krempf, Bruno Vergès, Murielle Mahl, Christophe Marçais, Philippe Moulin, Sybil Charrière
BACKGROUND: The LMF1 (lipase maturation factor 1) gene encodes a protein involved in lipoprotein lipase and hepatic lipase maturation. Homozygous mutations in LMF1 leading to severe hypertriglyceridemia (SHTG) are rare in the literature. A few additional rare LMF1 variants have been described with poor functional studies. OBJECTIVE: The aim of this study was to assess the frequency of LMF1 variants in a cohort of 385 patients with SHTG, without homozygous or compound heterozygous deleterious mutations identified in lipoprotein lipase (LPL), apolipoprotein A5 (APOA5), apolipoprotein C2 (APOC2), glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) genes, and to determine their functionality...
July 7, 2018: Journal of Clinical Lipidology
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