keyword
https://read.qxmd.com/read/38535952/a-proof-of-concept-for-a-hypolipidemic-brown-trout-model
#1
JOURNAL ARTICLE
Tiago Lourenço, Eduardo Rocha, José Fernando Gonçalves, Maria João Rocha, Tânia Vieira Madureira
The impacts of hypolipidemic pharmaceuticals on fish lipid metabolism remain unexplored. However, data points to similar effects and mechanisms of action between fish and humans. Therefore, fish may be a strong model for screening hypolipidemic drug candidates and water pollution by lipid-modulating agents. This study aimed to test a new hypolipidemic model assay with juvenile brown trout using atorvastatin (ATV)-a hypolipidemic chemical. We selected 17α-ethinylestradiol (EE2), known to cause hyperlipidemia in fish, to ensure model functionality...
March 15, 2024: Toxics
https://read.qxmd.com/read/38533994/mobile-phone-text-messaging-for-medication-adherence-in-secondary-prevention-of-cardiovascular-disease
#2
REVIEW
Julie Redfern, Qiang Tu, Karice Hyun, Matthew A Hollings, Nashid Hafiz, Clara Zwack, Caroline Free, Pablo Perel, Clara K Chow
BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death globally, accounting for almost 18 million deaths annually. People with CVDs have a five times greater chance of suffering a recurrent cardiovascular event than people without known CVDs. Although drug interventions have been shown to be cost-effective in reducing the risk of recurrent cardiovascular events, adherence to medication remains suboptimal. As a scalable and cost-effective approach, mobile phone text messaging presents an opportunity to convey health information, deliver electronic reminders, and encourage behaviour change...
March 27, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38532033/pcsk9-plasma-concentration-is-associated-with-epicardial-adipose-tissue-volume-and-metabolic-control-in-patients-with-type-1-diabetes
#3
JOURNAL ARTICLE
Helena Sardà, Cristina Colom, Sonia Benitez, Gemma Carreras, Judit Amigó, Inka Miñambres, David Viladés, Francisco Blanco-Vaca, Jose Luís Sanchez-Quesada, Antonio Pérez
Patients with type 1 diabetes (T1D) have a greater risk of cardiovascular disease. Proconvertase subtilisin-kexin 9 (PCSK9) is involved in the atherosclerosis process. This study aimed to determine the relationship between PCSK9 levels and epicardial adipose tissue (EAT) volume and cardiometabolic variables in patients with T1D. This was an observational cross-sectional study including 73 patients with T1D. Clinical, biochemical and imaging data were collected. We divided the patients into two groups according to their glycemic control and the EAT index (iEAT) percentile...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38529199/beneficial-role-of-amygdalin-extracts-against-animal-growth-regulator-boldjan-induced-cardiac-toxicity-injury-and-oxidative-stress-in-male-rats
#4
JOURNAL ARTICLE
Eman M Hussain, Sura M Alkadhimy, Asmaa M Neamah, Ehab Tousson
Millions of individuals have used illicit anabolic-androgenic steroids (AAS), but the long-term cardiovascular associations of these drugs remain incompletely understood. Boldjan is AAS medication which is used in veterinary medicine and by young adults aiming to have a better appearance improving their self-esteem. Therefore; the objective of the current investigation was to examine any potential preventative effects of amygdalin extract against anabolic steroid Boldjan induced cardic toxicity, injury and oxidative stress in male rat...
April 2024: Toxicology Research
https://read.qxmd.com/read/38528432/growth-performance-plasma-metabolites-meat-quality-and-meat-and-lipid-health-indices-of-new-zealand-white-rabbits-as-affected-by-dietary-dried-tomato-pomace-powder-supplementation-during-the-summer-season
#5
JOURNAL ARTICLE
Fawzia A Hassan, Manal S Mohamed, Doaa O Othman, Shawky A El-Medany, Rehab Ismail, Balasubramanian Balalmuralikrishnan, Rashed A Alhotan, Youssef A Attia, Fulvia Bovera, Khalid Mahrose
One hundred and twenty New Zealand White rabbits (NZW) (5-week-old; 735.27 ± 27.23 g) were kept in an open-sided house during the summer season. The experiment aims to evaluate the impacts of dried tomato pomace powder (DTPP) supplementation on rabbits' performance, blood metabolites, carcass traits, meat quality, and lipid and health indices of NZW rabbits during 5-13 weeks of age. The four treatments were a standard rabbit feed (control) and the control diet supplemented with 0.5, 1...
March 25, 2024: Journal of Animal Physiology and Animal Nutrition
https://read.qxmd.com/read/38526391/potential-risks-and-benefits-of-desiccated-thyroid-extract-for-the-treatment-of-hypothyroidism-a-systematic-review
#6
JOURNAL ARTICLE
Kamilla Ryom Riis, Camilla Bøgelund Larsen, Steen Joop Bonnema
BACKGROUND: Desiccated thyroid extract (DTE) is no longer recommended for treatment of hypothyroidism but is still in use. This review aimed to summarize the available literature on treatment with DTE in adult hypothyroid patients. METHODS: The search was conducted up until the 6th of January 2024 in six electronic databases. Two reviewers independently screened all search results. The retrieved studies compared DTE treatment with levothyroxine or combination therapy with liothyronine and levothyroxine...
March 25, 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38525632/dyslipidaemia-in-patients-with-chronic-kidney-disease-a-neglected-cardiovascular-risk-factor
#7
JOURNAL ARTICLE
M R Essop, F Seedat, F J Raal
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity and mortality in patients with chronic kidney disease (CKD). In addition, CKD itself is a coronary artery disease equivalent due to its atherogenic potential. Despite the role of CKD in ASCVD and recommendations to control lipid levels aggressively, landmark lipid studies have often excluded patients with advanced CKD. Furthermore, there is a scarcity of data on the use and efficacy of lipid-lowering therapy (LLT) in those with CKD in South Africa (SA)...
November 6, 2023: South African Medical Journal
https://read.qxmd.com/read/38521433/antihyperglycemic-and-antihyperlipidemic-effects-of-fruit-extract-of-hodgsonia-heteroclita-roxb-hook-f-thomson-in-diabetic-mice
#8
JOURNAL ARTICLE
Silu Basumatary, Partha Pradip Adhikari, Ajit Kumar Das, Nanjian Raaman, Gauri Dutt Sharma, Jatin Sarmah, Anjum Dihingia, Rinku Baishya, Prasenjit Manna, Jatin Kalita
ETHNOPHARMACOLOGICAL RELEVANCE: Hodgsonia heteroclita has been known as an important traditionally consumed medicinal plant of North-East India known to have antidiabetic properties. This study aims to investigate the effects of the ethanolic fruit extract of Hodgsonia heteroclita against hyperglycemia and hyperlipidemia by using streptozotocin (STZ) treated diabetic mice. MATERIALS AND METHODS: The fruits of H. heteroclita were collected from the various parts of Kokrajhar district, Assam India (Geographic coordinates: 26°24'3...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38520712/vldl-and-ldl-subfractions-enhance-the-risk-stratification-of-individuals-who-underwent-epstein-barr-virus-based-screening-for-nasopharyngeal-carcinoma-a-multicenter-cohort-study
#9
JOURNAL ARTICLE
Zhenhua Zhou, Tingxi Tang, Nan Li, Qiaocong Zheng, Ting Xiao, Yunming Tian, Jianda Sun, Longshan Zhang, Xiaoqing Wang, Yingqiao Wang, Feng Ye, Zekai Chen, Hanbin Zhang, Xiuting Zheng, Zhen Cai, Laiyu Liu, Jian Guan
Serological tests for Epstein-Barr virus (EBV) antibodies have been widely conducted for the screening of nasopharyngeal carcinoma (NPC) in endemic areas. Further risk stratification of NPC can be achieved through plasma lipoprotein and metabolic profiles. A total of 297 NPC patients and 149 EBV-positive participants are enrolled from the NCT03919552 and NCT05682703 cohorts for plasma nuclear magnetic resonance (NMR) metabolomic analysis. Small, dense very low density lipoprotein particles (VLDL-5) and large, buoyant low density lipoprotein particles (LDL-1) are found to be closely associated with nasopharyngeal carcinogenesis...
March 23, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38518848/substitution-of-dietary-monounsaturated-fatty-acids-from-olive-oil-for-saturated-fatty-acids-from-lard-increases-ldl-apolipoprotein-b-100-fractional-catabolic-rate-in-subjects-with-dyslipidemia-associated-with-insulin-resistance-a-randomized-controlled-trial
#10
JOURNAL ARTICLE
Louis-Charles Desjardins, Francis Brière, André J Tremblay, Maryka Rancourt-Bouchard, Jean-Philippe Drouin-Chartier, Jacques Corbeil, Valéry Lemelin, Amélie Charest, Ernst J Schaefer, Benoît Lamarche, Patrick Couture
BACKGROUND: The substitution of monounsaturated acids (MUFAs) for saturated fatty acids (SFAs) is recommended for cardiovascular disease prevention but its impact on lipoprotein metabolism in subjects with dyslipidemia associated with insulin resistance (IR) remains largely unknown. OBJECTIVE: This study aimed to evaluate the impact of substituting MUFAs for SFAs on the in vivo kinetics of apolipoprotein (apo)B-containing lipoproteins and on the plasma lipidomic profile in adults with IR-induced dyslipidemia...
March 20, 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38515677/the-influence-of-triglyceride-and-low-density-lipoprotein-target-levels-on-microcirculation-is-there-a-difference
#11
JOURNAL ARTICLE
Gergely Galos, Miklos Rabai, Reka Szabo, Rita Szalai, Kalman Toth, Peter Hegyi, Barbara Sandor
BACKGROUND AND AIMS: This study aimed to validate the role of high low-density lipoprotein cholesterol [LDL-C] and triglyceride [TG] treatment target levels on the microcirculation in a very high and high cardiovascular risk group. METHODS: 119 patients with high or very high cardiovascular [CV] risk were included. We have registered the main co-morbidities, smoking habits, body mass index [BMI] and the lipid lowering medication. Hematocrit, whole blood viscosity [WBV] and plasma viscosity [PV], red blood cell [RBC] aggregation and deformability and fibrinogen, total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], LDL-C and TG levels were determined...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38493102/hepatic-insulin-resistance-and-muscle-insulin-resistance-are-characterized-by-distinct-postprandial-plasma-metabolite-profiles-a-cross-sectional-study
#12
JOURNAL ARTICLE
Anouk Gijbels, Balázs Erdős, Inez Trouwborst, Kelly M Jardon, Michiel E Adriaens, Gijs H Goossens, Ellen E Blaak, Edith J M Feskens, Lydia A Afman
BACKGROUND: Tissue-specific insulin resistance (IR) predominantly in muscle (muscle IR) or liver (liver IR) has previously been linked to distinct fasting metabolite profiles, but postprandial metabolite profiles have not been investigated in tissue-specific IR yet. Given the importance of postprandial metabolic impairments in the pathophysiology of cardiometabolic diseases, we compared postprandial plasma metabolite profiles in response to a high-fat mixed meal between individuals with predominant muscle IR or liver IR...
March 16, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38489119/distinct-lipidomic-profiles-between-people-living-with-hiv-treated-with-e-c-f-taf-or-b-f-taf-an-open-label-prospective-cohort-study
#13
JOURNAL ARTICLE
Zhikai Wan, Junwei Su, Xueling Zhu, Xiang Liu, Yongzheng Guo, Dairong Xiang, Xiaotang Zhou, Xiaorong Peng, Ran Tao, Qing Cao, Guanjing Lang, Ying Huang, Biao Zhu
INTRODUCTION: Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) has been increasingly replaced by bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in the treatment of human immunodeficiency virus (HIV) owing to its more favorable pharmacokinetics and fewer drug-drug interactions. However, the effect of this switch on plasma lipids and lipidomic profiles remains poorly characterized. METHODS: HIV infected patients on an E/C/F/TAF regimen were recruited into the study and followed up every 12 weeks...
March 15, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38488124/apolipoprotein-e-containing-lipoproteins-and-their-extracellular-interactions-with-lrp1-affect-lps-induced-inflammation
#14
JOURNAL ARTICLE
Shogo Akahane, Hiroto Matsuura, Takahiro Kaido, Yoko Usami, Nau Ishimine, Takeshi Uehara, Kazuyoshi Yamauchi
The linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion particles (apoE-EP)...
March 18, 2024: Biological Chemistry
https://read.qxmd.com/read/38484368/reductions-in-remnant-cholesterol-and-vldl-cholesterol-through-inhibition-of-angptl3-protein-synthesis-an-analysis-from-the-translate-timi-70-trial
#15
JOURNAL ARTICLE
Andre Zimerman, Stephen D Wiviott, Jeong-Gun Park, Sabina A Murphy, Xinhui Ran, Candace R Bramson, Madelyn Curto, Vesper Ramos, Alexandra Jevne, Julia F Kuder, Subodh Verma, Wojtek Wojakowski, Steven G Terra, Marc S Sabatine, Brian A Bergmark, Nicholas A Marston
AIMS: Remnant cholesterol and very low-density lipoprotein cholesterol (VLDL-C) are increasingly recognized risk factors for atherosclerotic disease with few therapeutic options. Angiopoietin-like 3 (ANGPTL3), a key protein in the metabolism of triglyceride-rich lipoproteins, is a promising target. METHODS AND RESULTS: TRANSLATE-TIMI 70 was a double-blind, placebo-controlled randomized trial testing seven dose regimens of vupanorsen, an antisense oligonucleotide against ANGPTL3, in adults with non-HDL-C ≥ 100 mg/dL and triglycerides 150-500 mg/dL...
March 14, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38479618/cymbopogon-schoenanthus-l-extract-ameliorates-high-fat-diet-induced-obesity-and-dyslipidemia-via-reducing-expression-of-lipogenic-and-thermogenic-proteins
#16
JOURNAL ARTICLE
Asmaa Elebishehy, Mohamed M Ahmed, Badr Aldahmash, Mostafa Abdelgaber Mohamed, Aya A Shetaia, Shaden A M Khalifa, Mabrouk Attia Abd Eldaim, Hesham R El-Seedi, Nermeen Yosri
Globally, obesity has become one of the major health problems. This study was conducted to evaluate the anti-obesity potential of Cymbopogon schoenanthus methanolic extract (CS) in rats. Fifty male Wistar rats of six to eight weeks-old, 100-120 g body weight (BW) was randomly assigned into 5 groups (n = 10): Control group was fed basal diet. CS-group was supplied with basal diet and orally given CS (200 mg/kg BW) for 12 weeks. HFD-group was fed a high fat diet (HFD) for 18 weeks...
March 11, 2024: Fitoterapia
https://read.qxmd.com/read/38477705/feather-meal-processing-methods-impact-the-production-parameters-blood-biochemical-indices-gut-function-and-hepatic-enzyme-activity-in-broilers
#17
JOURNAL ARTICLE
Hassan Safari, Ardeshir Mohit, Maziar Mohiti-Asli
This study investigated the effects of feather meal (FM) processing methods on production parameters, blood biochemical indices, intestinal morphology, digestive and hepatic enzyme activities, and gastrointestinal tract pH and microflora of broilers. A total of 480-day-old male broilers were used for 42 days in a completely randomized design with eight treatments and five replicates (12 chicks/replicate). Treatments were: (1) A control diet (without FM), (2) Diet containing 4% raw FM (RFM), (3) Diet containing 4% processed feather meal (PFM) by autoclave (Au-PFM), (4) Diet containing 4% fermented FM (FFM) by Bacillus licheniformis (Bl-FFM), (5) Diet containing 4% FFM by Bacillus subtilis (Bs-FFM), (6) Diet containing 4% FFM by Aspergillus niger (An-FFM), (7) Diet containing 4% FFM by B...
March 13, 2024: Journal of Animal Science
https://read.qxmd.com/read/38474500/nmr-based-analysis-of-plasma-lipoprotein-subclass-and-lipid-composition-demonstrate-the-different-dietary-effects-in-apoe-deficient-mice
#18
JOURNAL ARTICLE
Cheng-Hung Yang, Yu-Hsuan Ho, Hsiang-Yu Tang, Chi-Jen Lo
Plasma lipid levels are commonly measured using traditional methods such as triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and cholesterol (CH). However, the use of newer technologies, such as nuclear magnetic resonance (NMR) with post-analysis platforms, has made it easier to assess lipoprotein profiles in research. In this study involving ApoE-deficient mice that were fed high-fat diets, significant changes were observed in TG, CH, free cholesterol (FC), and phospholipid (PL) levels within the LDL fraction...
February 24, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38472823/exploring-therapeutic-potential-of-pleurotus-ostreatus-and-agaricus-bisporus-mushrooms-against-hyperlipidemia-and-oxidative-stress-using-animal-model
#19
JOURNAL ARTICLE
Touseef Iqbal, Muhammad Sohaib, Sanaullah Iqbal, Habib Rehman
The mushrooms oyster ( Pleurotus ostreatus ) and white button ( Agaricus bisporus ) contain bioactive compounds that have potential beneficial effects on hypercholesterolemia and cardiovascular diseases. In this study, hypolipidemic and antioxidative potential of these mushrooms' extract were explored using hypercholesterolemic (HC) rats as animal model. For the study, 56 adult rats were divided into seven groups, i.e., G1 (negative control), G2 (positive control group), G3 (HC rats with statin drug orally), G4 and G5 (HC rats @ 100 and 200 mg/kg body weight (BW) dose of oyster mushroom extracts), and G6 and G7 (HC rats @ 100 and 200 mg/kg BW dose of white button mushroom extracts)...
February 26, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38469394/betaine-alleviates-high-fat-diet-induced-excessive-lipid-deposition-in-gibel-carp-hepatopancreas-and-l8824-cells-by-enhancing-vldl-secretion-through-hnf4-%C3%AE-mttp-pathway
#20
JOURNAL ARTICLE
Xiaojing Dong, Jianqiao Wang, Mengjie Zhao, Xuedi Du, Hongying Fan, Yuanyuan Fu, Zhiyuan Gong, Shuyan Miao
Betaine, a methyl donor, plays a crucial role in lipid metabolism. Previous studies have shown that appropriate betaine supplementation in a high-fat diet reduces triglycerides (TG) of serum and hepatopancreas in fish. However, the underlying mechanism remains unclear. This study examined whether betaine can enhance the secretion of very low-density lipoprotein (VLDL) and sought to identify the specific mechanisms through which this enhancement occurs. A lipid accumulation model was established in gibel carp and L8824 cells using a high-fat diet and oleic acid, respectively...
2024: Aquaculture Nutrition
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