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Etienne Guillocheau, Cyrielle Garcia, Gaëtan Drouin, Léo Richard, Daniel Catheline, Philippe Legrand, Vincent Rioux
Trans-palmitoleic acid (trans-C16:1 n-7 or trans-Δ9-C16:1, TPA) is believed to improve several metabolic parameters according to epidemiological data. TPA may mainly come from direct intakes: however, data are inconsistent due to its very low amount in foods. Instead, TPA might arise from dietary trans-vaccenic acid (trans-C18:1 n-7, TVA), which is more abundant in foods. TVA chain-shortening would be involved, but formal proof of concept is still lacking to our knowledge. Therefore, the present study aimed at providing in vitro and in vivo evidence of TVA retroconversion to TPA...
September 21, 2018: Journal of Nutritional Biochemistry
Radha Yadav, Debpriyo Kumar Dey, Rishika Vij, Sunita Meena, Rajeev Kapila, Suman Kapila
Interest in probiotics has grown significantly in the last decades due to their reported nutritional and health promoting effects. The aim of this study is to investigate the therapeutic potential of probiotic fermented milk (PFM) prepared using three different probiotic strains i.e. Lactobacillus rhamnosus MTCC: 5957, Lactobacillus rhamnosus MTCC: 5897 and Lactobacillus fermentum MTCC: 5898; independently or in combination, for treating streptozotocin induced type-1 diabetes in male Wistar rats. Diabetic rats were fed with PFM preparations for 6 weeks and then analyzed for the various biochemical parameters associated...
October 10, 2018: Microbial Pathogenesis
Motahareh Hasani, Shirin Djalalinia, Farshad Sharifi, Mehdi Varmaghani, Maryam Zarei, Mohammad Esmaeili Abdar, Hamid Asayesh, Mehdi Noroozi, Amir Kasaeian, Armita Mahdavi Gorabi, Mostafa Qorbani
Selenium is an essential mineral that plays a key role in plenty of major metabolic processes. A growing body of literature has shown that selenium deficiency leads to an increase in plasma TC and TG levels. This study explores the effect of selenium supplementation on serum level of lipid profile [total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low density lipoprotein (VLDL)]. We systematically searched PubMed/MEDLINE, ISI/WOS, and Scopus (from their commencements to Jan 2016) to identify the papers investigating the association between the intake of selenium and lipid profile...
October 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Pratik B Sandesara, Salim S Virani, Sergio Fazio, Michael D Shapiro
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) is a well-established mediator of atherosclerosis and a key target for intervention for the primary and secondary prevention of ASCVD. However, despite significant reduction in LDL-C, patients continue to have recurrent ASCVD events. Hypertriglyceridemia maybe an important contributor of this residual risk. Observational and genetic epidemiological data strongly support a causal role of triglycerides and the cholesterol content within triglyceride-rich lipoproteins (TGRL) and/or remnant cholesterol (RC) in the development of ASCVD...
October 11, 2018: Endocrine Reviews
Kimberly M Tippens, Andrew Erlandsen, Douglas A Hanes, Robert Graybill, Courtney Jackson, Julie Briley, Heather Zwickey
OBJECTIVE: To assess the feasibility of measuring the health impacts of a 12-week naturopathic whole foods nutrition education course among adults with or at risk for prediabetes. DESIGN: A pilot nonrandomized pre-post intervention design investigated physiological changes associated with participation in a 12-week structured naturopathic nutrition education course. Follow-up measures were assessed at 6 and 12 months from baseline. SETTINGS/LOCATION: Three community-based kitchens in Oregon...
October 12, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Paula Dlugosz, Johannes Nimpf
Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the clathrin machinery to mediate endocytosis of macromolecules but also interact with other adapter proteins to perform as signal transduction receptors. The best characterized signaling pathway in which ApoER2 and VLDL receptor (VLDLR) are involved is the Reelin pathway. This pathway plays a pivotal role in the development of laminated structures of the brain and in synaptic plasticity of the adult brain...
October 9, 2018: International Journal of Molecular Sciences
Natalia Presa, Robin D Clugston, Susanne Lingrell, Samuel E Kelly, Alfred H Merrill, Sayantan Jana, Zamaneh Kassiri, Antonio Gómez-Muñoz, Dennis E Vance, Rene L Jacobs, Jelske N van der Veen
Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. Pemt-/- mice are protected from high-fat diet (HFD)-induced obesity and insulin resistance, but develop severe non-alcoholic fatty liver disease (NAFLD) when fed a HFD, mostly due to impaired VLDL secretion. Oxidative stress is thought to be an essential factor in the progression from simple steatosis to steatohepatitis. Vitamin E is an antioxidant that has been clinically used to improve NAFLD pathology...
October 6, 2018: Biochimica et biophysica acta. Molecular basis of disease
Mathijs C Bodde, Maaike P J Hermans, J Wouter Jukema, Martin J Schalij, Willem M Lijfering, Frits R Rosendaal, Fred P H T M Romijn, L Renee Ruhaak, Arnoud van der Laarse, Christa M Cobbaert
INTRODUCTION: The current way to assess the risk of cardiovascular disease (CVD) is to measure conventional lipid and lipoprotein cholesterol fractions. Despite the success of statin treatment, residual cardiovascular risk remains high. Therefore, the value of extensive serum apolipoprotein (apo) profiling to assess the risk of ST-segment elevation myocardial infarction (STEMI) and of major adverse cardiac events (MACE) in patients with STEMI was investigated in a case-control design...
October 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Cassandra Sparkes, Robert Gibson, Andrew Sinclair, Paul L Else, Barbara J Meyer
Omega-3 long chain polyunsaturated fatty acid ( n -3 LCPUFA) supplementation has been shown to improve plasma lipid profiles in men and post-menopausal women, however, data for pre-menopausal women are lacking. The benefits of intakes less than 1 g/day have not been well studied, and dose⁻response data is limited. The aim of this study was to determine the effect of low doses of docosahexaenoic acid (DHA)-rich tuna oil on plasma triglyceride (TG) lowering in pre-menopausal women, and investigate if low dose DHA-rich tuna oil supplementation would increase the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle sizes...
October 8, 2018: Nutrients
Hanmant Barkate, Piyush Patel, Dimple Shah, Falgun Vyas
Introduction: This study was conducted to evaluate the safety and efficacy of fixed-dose combination (FDC) of rosuvastatin and choline fenofibrate in comparison to rosuvastatin and fenofibrate FDC among Indian patients of mixed dyslipidemia. This would be a first study evaluating FDC of rosuvastatin and choline fenofibrate in Indian population. Methods: A multicenter, open-label, randomized, active controlled, comparative, parallel-design study was conducted at 12 centers spread all across India...
September 2018: Indian Journal of Endocrinology and Metabolism
G M Zou, L Zhuo, M Tan, W G Li
Objective: To investigate the clinicopathologic features of lipoprotein glomerulopathy (LPG). Methods: A total of 6 cases (5 males and 1 female, with a mean age of 27.5 years and age range of 11-53 years) of lipoprotein glomerulopathy with complete clinicopathologic data were enrolled. Except for light microscope, immunofluorescence and electron microscopic examination, renal biopsy tissues were checked by oil red O staining. The gene map of apolipoprotein E (ApoE) of 2 cases were analyzed. Results: All 6 cases presented with heavy proteinuria or nephrotic syndrome, and high level of low-density lipoprotein (LDL), very low-density lipoprotein (vLDL), ApoE...
September 25, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Neslihan Akdogan, Nuran Alli, Pinar Incel Uysal, Canan Topcuoglu, Tuba Candar, Turan Turhan
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. HS has been associated with obesity, adipokine imbalance, dyslipidemia, pro-inflammation, and metabolic syndrome (MS). The aim of this study was to determine the association between HS, and serum visfatin levels (SVLs), small-dense low-density lipoprotein cholesterol (sdLDL-C), and ischemia-modified albumin (IMA), as well as the association between HS, and smoking, alcohol consumption, anthropometric measurements, blood pressures (BPs), fasting blood glucose (FBG) and lipids, inflammatory markers, homocysteine, uric acid (UA), serum insulin levels (SILs), insulin resistance (IR) and MS, so as to identify relevant risk factors for HS...
October 6, 2018: Archives of Dermatological Research
M Cheurfa, H H Abdallah, R Allem, A Noui, C M N Picot-Allain, F Mahomoodally
Aqueous and ethanol extracts prepared from leaves of Olea europaea L. were evaluated for in vitro antioxidant and in vivo hypocholesterolemic effect. The result of administration of O. europaea leaf extracts on serum total cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) in hypercholesterolaemic mice was evaluated. In addition, rutin and luteolin, reported to occur naturally in O. europaea leaves, were docked against HMG-CoA reductase, the rate-limiting enzyme in cholesterol metabolism...
October 4, 2018: Food and Chemical Toxicology
Camyla Rocha de Carvalho Guedine, Liana Clébia de Morais Pordeus, Tania Regina Riul, Alceu Afonso Jordão, Sebastião Sousa Almeida
OBJECTIVE: Evaluate the impact of the cafeteria diet during lactation and/or post-lactation on physiological parameters and anxiety in the offspring of Wistar rats. METHODS: Male offspring of Wistar rats (n = 60) were randomized into four groups: Control (C), Lactation Cafeteria (LC), Post-lactation Cafeteria (PC) and Total Cafeteria (TC). Later in adult life the animals were submitted to the behavioral (elevated plus-maze and open field) and biological (body weight, consumption and food preference, glycemia, total cholesterol, LDL cholesterol, HDL cholesterol, VLDL cholesterol, triglycerides, total proteins, urea, creatinine, bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, serum protein, and oxidative stress) evaluations...
October 5, 2018: Nutritional Neuroscience
Mehri Jamilian, Niloufar Kazemi Sabzevar, Zatollah Asemi
Data on the effects of magnesium and vitamin E co-supplementation on glycemic control and markers of cardio-metabolic risk of patients with polycystic ovary syndrome (PCOS) were collected. This investigation was conducted to evaluate the effects of magnesium and vitamin E co-supplementation on glycemic control and markers of cardio-metabolic risk in women with PCOS. This randomized, double-blind, placebo-controlled trial was carried out on 60 women with PCOS, aged 18-40 years old. Participants were randomly divided into two groups to receive 250 mg/day magnesium plus 400 mg/day vitamin E supplements or placebo (n=30 each group) for 12 weeks...
October 4, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Ayman S Salah, Omar A Ahmed-Farid, Mahmoud S El-Tarabany
The objective of the current research was to explore the possible impacts of dietary supplementation with synbiotic and/or organic acids (OA) on the performance traits, carcass yields and muscle amino acid and fatty acid (FA) profiles of broilers. Randomly, a total of 160 day-old chicks (Ross 308) were assigned into four equal groups (40 birds each), with each group subdivided into eight replicates (five birds/pen). The control group (CON) fed the basal diet with no supplements, while diets of the treated groups were supplemented with OA (Sodium butyrate 40%; 1 g/kg), synbiotic (comprised Bacillus subtilis, Saccharomyces cerivisiae, Streptococcus faecium, Mannan-Oligosaccharides and β-Glucan; 1 g/kg) and equal mix of OA and synbiotic (2 g/kg)...
October 2, 2018: Journal of Animal Physiology and Animal Nutrition
Constantino Flores-Reséndiz, Alexandra E Soto-Piña, Roxana Valdés-Ramos, Alejandra D Benítez-Arciniega, Patricia Tlatempa-Sotelo, Ana Laura Guadarrama-López, Beatriz E Martínez-Carrillo, Caroline C Pulido-Alvarado
Objective: The objective of this study was to determine whether cardiovascular disease (CVD) risk factors and stress hormones are associated with cognitive performance in Mexican adolescents. Methods: This was a cross-sectional study including 139 Mexican adolescents 10-14 years old. Participants were divided into three categories: 0, 1-2, and ≥3 CVD risk factors. These factors included: high-density lipoprotein-cholesterol (HDL-C) <40 mg/dl; waist circumference (WC) ≥90th percentile for age and sex, systolic or diastolic blood pressure ≥90th percentile for age, sex, and height; and triacylglycerols (TGs) ≥110 mg/dl...
September 28, 2018: Journal of Pediatric Psychology
Hayder M Alkuraishy, Ali I Al-Gareeb, Huda J Waheed
Objectives: The objective of the study is to investigate the effects of statins on the lipoprotein-associated phospholipase A2 (Lp-PLA2) mass in patients with ischemic stroke. Materials and Methods: A total number of 59 patient ages 43-69 years with cerebral stroke compared to 39 healthy controls that matching the age and body weight. The patients were divided into 32 patients on statins therapy assigned as statins users and 27 patients, not on statins therapy assigned as nonstatins users...
October 2018: Journal of Neurosciences in Rural Practice
Harjit Kaur, Badaruddoza Badaruddoza, Veena Bains, Anupam Kaur
BACKGROUND AND AIMS: At present obesity and metabolic syndrome (MetS) in India are the most challenging health problems. It is also well accepted that obesity is a significant risk factor for the development of metabolic syndrome and other degenerative diseases. Many studies have reported that single-nucleotide polymorphisms (SNPs) of the adiponectin (ADIPOQ) gene have been associated with obesity and its related disorders. Here, we aimed to investigate the association of two intronic variants in ADIPOQ gene, -3971A>G (rs822396) and +276G>T (rs1501299) with obesity and metabolic syndrome...
2018: PloS One
Bikas C Debnath, Purnendu Biswas, Barun Roy
Three hundred thirty-day-old unsexed commercial broiler chicks (Vencobb-400) with initial average body weight of 44.04 ± 0.42 g were allocated into five experimental groups, in a completely randomized design (CRD) with 21-day experiment. Groups were formed according to dose of supplemental L-threonine in various rations i.e., 100% NRC specification, 100% threonine of Vencobb-400 strain specification, 110% threonine of Vencobb-400 strain specification, 120% of threonine of Vencobb-400 strain specification and 130% threonine of Vencobb-400 strain specification...
September 28, 2018: Journal of Animal Physiology and Animal Nutrition
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