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https://www.readbyqxmd.com/read/28644904/sustained-pasi-dlqi-and-eq-5d-response-of-biological-treatment-in-psoriasis-10-years-of-real-world-data-in-the-swedish-national-psoriasis-register
#1
F Hjalte, K Steen Carlsson, M Schmitt-Egenolf
BACKGROUND: Few studies have analysed the long-term effects of biological treatment in psoriasis. PsoReg, the Swedish national register for systemic psoriasis treatment, started in 2006 and includes now ten years of real-world data on effectiveness of biological treatment. OBJECTIVE: To analyse long-term real-world outcome data on biological-naïve patients with moderate to severe psoriasis after switching to biological treatment. METHODS: Observational study including biological-naïve patients with at least one registration of outcome before switching to biological treatment while included in PsoReg and at least one follow-up visit...
June 23, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28644872/helicobacter-pylori-gene-silencing-in-vivo-demonstrates-urease-is-essential-for-chronic-infection
#2
Aleksandra W Debowski, Senta M Walton, Eng-Guan Chua, Alfred Chin-Yen Tay, Tingting Liao, Binit Lamichhane, Robyn Himbeck, Keith A Stubbs, Barry J Marshall, Alma Fulurija, Mohammed Benghezal
Helicobacter pylori infection causes chronic active gastritis that after many years of infection can develop into peptic ulceration or gastric adenocarcinoma. The bacterium is highly adapted to surviving in the gastric environment and a key adaptation is the virulence factor urease. Although widely postulated, the requirement of urease expression for persistent infection has not been elucidated experimentally as conventional urease knockout mutants are incapable of colonization. To overcome this constraint, conditional H...
June 23, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28644851/comorbidities-in-the-diseasome-are-more-apparent-than-real-what-bayesian-filtering-reveals-about-the-comorbidities-of-depression
#3
Peter Marx, Peter Antal, Bence Bolgar, Gyorgy Bagdy, Bill Deakin, Gabriella Juhasz
Comorbidity patterns have become a major source of information to explore shared mechanisms of pathogenesis between disorders. In hypothesis-free exploration of comorbid conditions, disease-disease networks are usually identified by pairwise methods. However, interpretation of the results is hindered by several confounders. In particular a very large number of pairwise associations can arise indirectly through other comorbidity associations and they increase exponentially with the increasing breadth of the investigated diseases...
June 23, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28644820/investigation-of-real-tissue-water-equivalent-path-lengths-using-an-efficient-dose-extinction-method
#4
Rongxiao Zhang, Esther Baer, Kyung-Wook Jee, Gregory C Sharp, Jay Flanz, Hsiao-Ming Lu
For proton therapy, an accurate conversion of CT HU to relative stopping power (RSP) is essential. Validation of the conversion based on real tissue samples is more direct than the current practice solely based on tissue substitutes and can potentially address variations over the population. Based on a novel dose extinction method, we measured water equivalent path lengths (WEPL) on animal tissue samples to evaluate the accuracy of CT HU to RSP conversion and potential variations over a population. A broad proton beam delivered a spread out Bragg peak to the samples sandwiched between a water tank and a 2D ion-chamber detector...
June 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28644729/promoting-prenatal-exercise-from-a-sociocultural-and-life-course-perspective-an-embodied-conceptual-framework
#5
Shannon Jette, Julie Maier, Katelyn Esmonde, Cherise Davis
PURPOSE: Prenatal exercise is a health behavior that is receiving growing attention amid concern that women in Western societies are gaining excess weight during pregnancy and contributing to future obesity in both the mother and child. In this article, we draw on insights from the fields of social epidemiology and social theory of the body to examine existing prenatal exercise interventions and to propose a multidimensional framework intended to guide future theorizing and intervention design...
June 23, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28644491/mastering-high-resolution-tip-enhanced-raman-spectroscopy-towards-a-shift-of-perception
#6
REVIEW
Marie Richard-Lacroix, Yao Zhang, Zhenchao Dong, Volker Deckert
Recent years have seen tremendous improvement of our understanding of high resolution reachable in TERS experiments, forcing us to re-evaluate our understanding of the intrinsic limits of this field, but also exposing several inconsistencies. On the one hand, more and more recent experimental results have provided us with clear indications of spatial resolutions down to a few nanometres or even on the subnanometre scale. Moreover, lessons learned from recent theoretical investigations clearly support such high resolutions, and vice versa the obvious theoretical impossibility to evade high resolution from a purely plasmonic point of view...
June 23, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28644482/one-thousand-fold-enhancement-of-high-field-liquid-nuclear-magnetic-resonance-signals-at-room-temperature
#7
Guoquan Liu, Marcel Levien, Niels Karschin, Giacomo Parigi, Claudio Luchinat, Marina Bennati
Nuclear magnetic resonance (NMR) is a fundamental spectroscopic technique for the study of biological systems and materials, molecular imaging and the analysis of small molecules. It detects interactions at very low energies and is thus non-invasive and applicable to a variety of targets, including animals and humans. However, one of its most severe limitations is its low sensitivity, which stems from the small interaction energies involved. Here, we report that dynamic nuclear polarization in liquid solution and at room temperature can enhance the NMR signal of (13)C nuclei by up to three orders of magnitude at magnetic fields of ∼3 T...
July 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28644443/unexpected-genomic-features-in-widespread-intracellular-bacteria-evidence-for-motility-of-marine-chlamydiae
#8
Astrid Collingro, Stephan Köstlbacher, Marc Mussmann, Ramunas Stepanauskas, Steven J Hallam, Matthias Horn
Chlamydiae are obligate intracellular bacteria comprising important human pathogens and symbionts of protists. Molecular evidence indicates a tremendous diversity of chlamydiae particularly in marine environments, yet our current knowledge is based mainly on terrestrial representatives. Here we provide first insights into the biology of marine chlamydiae representing three divergent clades. Our analysis of single-cell amplified genomes revealed hallmarks of the chlamydial lifestyle, supporting the ancient origin of their characteristic developmental cycle and major virulence mechanisms...
June 23, 2017: ISME Journal
https://www.readbyqxmd.com/read/28644437/more-alive-than-dead-non-apoptotic-roles-for-caspases-in-neuronal-development-plasticity-and-disease
#9
REVIEW
Amrita Mukherjee, Darren W Williams
Nervous systems are arguably the most fascinating and complex structures in the known universe. How they are built, changed by experience and then degenerate are some of the biggest questions in biology. Regressive phenomena, such as neuron pruning and programmed cell death, have a key role in the building and maintenance of the nervous systems. Both of these cellular mechanisms deploy the caspase family of protease enzymes. In this review, we highlight the non-apoptotic function of caspases during nervous system development, plasticity and disease, particularly focussing on their role in structural remodelling...
June 23, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28644430/the-clinical-landscape-for-sma-in-a-new-therapeutic-era
#10
REVIEW
K Talbot, E F Tizzano
Despite significant advances in basic research, the treatment of degenerative diseases of the nervous system remains one of the greatest challenges for translational medicine. The childhood onset motor neuron disorder spinal muscular atrophy (SMA) has been viewed as one of the more tractable targets for molecular therapy, due to a detailed understanding of the molecular genetic basis of the disease. In SMA, inactivating mutations in the SMN1 gene can be partially compensated for by limited expression of SMN protein from a variable number of copies of the SMN2 gene, which provides both a molecular explanation for phenotypic severity and a target for therapy...
June 23, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28644397/relationship-between-remote-sensing-data-plant-biomass-and-soil-nitrogen-dynamics-in-intensively-managed-grasslands-under-controlled-conditions
#11
Christoph Knoblauch, Conor Watson, Clara Berendonk, Rolf Becker, Nicole Wrage-Mönnig, Florian Wichern
The sustainable use of grasslands in intensive farming systems aims to optimize nitrogen (N) inputs to increase crop yields and decrease harmful losses to the environment at the same time. To achieve this, simple optical sensors may provide a non-destructive, time- and cost-effective tool for estimating plant biomass in the field, considering spatial and temporal variability. However, the plant growth and related N uptake is affected by the available N in the soil, and therefore, N mineralization and N losses...
June 23, 2017: Sensors
https://www.readbyqxmd.com/read/28644392/development-of-bone-targeting-drugs
#12
REVIEW
Molly Stapleton, Kazuki Sawamoto, Carlos J Alméciga-Díaz, William G Mackenzie, Robert W Mason, Tadao Orii, Shunji Tomatsu
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with either of two general targeting moieties, aimed at the entire skeletal system or a specific cell type. Most bone-targeting drugs utilize an affinity to hydroxyapatite, a major component of the bone matrix that includes a high concentration of positively-charged Ca(2+)...
June 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28644388/cellular-uptake-and-delivery-dependent-effects-of-tb-3-doped-hydroxyapatite-nanorods
#13
Yan Wei, Ying He, Xiyu Li, Haifeng Chen, Xuliang Deng
With the increasing interest in hydroxyapatite (HA) nanostructures for use in biomedicine, the systematic evaluation of their potential effects on biological systems is becoming critically important. In this work, we report the in vitro cellular uptake, in vivo tissue distributions and toxicity of Tb(3+)-doped HA (HA-Tb) after short-, intermediate-, and long-term exposure. Transmission electron microscopy analysis indicated that HA-Tb was taken up by cells via vesicle endocytosis. Cell proliferation and cytotoxicity assay, combined with confocal laser scanning microscopy, indicated excellent cell viability with no changes in cell morphology at the examined doses...
June 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28644140/a-pathways-based-prediction-model-for-classifying-breast-cancer-subtypes
#14
Tong Wu, Yunfeng Wang, Ronghui Jiang, Xinliang Lu, Jiawei Tian
Breast cancer is highly heterogeneous and is classified into four subtypes characterized by specific biological traits, treatment responses, and clinical prognoses. We performed a systemic analysis of 698 breast cancer patient samples from The Cancer Genome Atlas project database. We identified 136 breast cancer genes differentially expressed among the four subtypes. Based on unsupervised clustering analysis, these 136 core genes efficiently categorized breast cancer patients into the appropriate subtypes. Functional enrichment based on Kyoto Encyclopedia of Genes and Genomes analysis identified six functional pathways regulated by these genes: JAK-STAT signaling, basal cell carcinoma, inflammatory mediator regulation of TRP channels, non-small cell lung cancer, glutamatergic synapse, and amyotrophic lateral sclerosis...
June 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28644042/a-review-on-recent-applications-of-high-performance-liquid-chromatography-in-metal-determination-and-speciation-analysis
#15
Susheela Rani, Neha Sharma, Ashok Kumar Malik
High performance liquid chromatography has several advantages over the conventional methods due to their operational simplicity. It is a vital tool to determine metal ions having same mass but different electronic configuration, to separate complex mixtures and to resolve ions that may be indistinguishable by mass spectrometry alone. Metal ions play vital role in many biological processes and involved in setting up of many diseases. Therefore the development of simple methods for the detection and quantification of metals in real samples might serve as diagnostic tools for various diseases...
June 23, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/28644025/a-mitochondria-targeted-cryptocyanine-based-photothermogenic-photosensitizer
#16
Hyo Sung Jung, Jae Hong Lee, Kyutae Kim, Seyoung Koo, Peter Verwilst, Jonathan L Sessler, Chulhun Kang, Jong Seung Kim
Cryptocyanine-based probes exhibit highly efficient photothermal conversion and represent a new class of photothermal agents for use in photothermal therapy (PTT). With the thermal susceptibility of mitochondria in mind, we have prepared a mitochondria-targeted, NIR-absorbing cryptocyanine probe (Mito-CCy) and evaluated its photophysical properties, photothermal conversion efficiency, biological compatibility, cytotoxicity, and mitochondrial localization in HeLa cells. Upon subjecting 0.5 mL of a PBS buffer solution (10 mM, pH 7...
June 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28644020/the-underestimated-halogen-bonds-forming-with-protein-backbone-in-protein-data-bank
#17
Qian Zhang, Zhijian Xu, Jiye Shi, Weiliang Zhu
Halogen bonds (XBs) are attracting increasing attention in biological systems. Protein Data Bank (PDB) archives experimentally determined XBs in biological macromolecules. However, no software for structure refinement in X-Ray crystallography takes into account of XBs, which might result in the weakening or even vanishing of experimentally determined XBs in PDB. In our previous study, we showed that side-chain XBs forming with protein side chains are underestimated in PDB on the basis of the phenomenon that the proportion of side-chain XBs to overall XBs decreases as structural resolution becomes lower and lower...
June 23, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28644007/cyclotides-as-tools-in-chemical-biology
#18
Simon J de Veer, Joachim Weidmann, David J Craik
Among the various molecules that plants produce for defense against pests and pathogens, cyclotides stand out as exceptionally stable and structurally unique. These ribosomally synthesized peptides are around 30 amino acids in size, and are stabilized by a head-to-tail cyclic peptide backbone and three disulfide bonds that form a cystine knot. They occur in certain plants of the Rubiaceae, Violaceae, Cucurbitaceae, Fabaceae, and Solanaceae families, with an individual plant producing up to hundreds of different cyclotides...
June 23, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28643475/tailoring-of-physicochemical-properties-of-nanocarriers-for-effective-anti-cancer-applications
#19
REVIEW
Swaroop Chakraborty, Geethanjali S Dhakshinamurthy, Superb K Misra
Nanotechnology has emerged strongly as a viable option to overcome the challenge of early diagnosis and effective drug delivery, for cancer treatment. Emerging research articles have expounded the advantages of using a specific type of nanomaterial-based system called as "nanocarriers," for anti-cancer therapy. The nanocarrier system is used as a transport unit for targeted drug delivery of the therapeutic drug moiety. In order for the nanocarriers to be effective for anticancer therapy, their physicochemical parameter needs to be tuned so that bio-functionalisation can be achieved to a) allow drugs being attached to the substrate and for their controlled release, b) ensure the stability of the nanocarrier up to the point of delivery, and c) clearance of the nanocarrier after the delivery...
June 23, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28643260/a-simple-protocol-for-loss-of-function-analysis-in-xenopus-tropicalis-founders-using-the-crispr-cas-system
#20
Yuto Sakane, Ken-Ich T Suzuki, Takashi Yamamoto
Xenopus tropicalis is a versatile model organism for studying basic biology such as developmental biology and cell biology, and for biomedical research on human diseases. Current genome editing techniques enable researchers to easily perform gene targeting in various animals. Among them, gene knockout using the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated (Cas) (CRISPR-Cas) system has recently become an indispensable strategy for loss-of-function analysis in vivo. Because of its ease of use, time, and cost efficiencies, CRISPR-Cas has also been applied to X...
2017: Methods in Molecular Biology
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