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https://www.readbyqxmd.com/read/30546325/increased-risk-of-metabolic-syndrome-in-antidepressants-users-a-mini-review
#1
REVIEW
Carla Gramaglia, Eleonora Gambaro, Giuseppe Bartolomei, Paolo Camera, Maira Chiarelli-Serra, Luca Lorenzini, Patrizia Zeppegno
Mounting evidence has shown that the risk of metabolic syndrome (MetS) is substantially overlapping in the diagnostic subgroups of psychiatric disorders. While it is widely acknowledged that patients receiving antipsychotic medications are at higher risk of MetS than antipsychotic-naive ones, the association between antidepressants and MetS is still debated. The goal of our mini review was to analyse the relationship among depressive symptoms, antidepressant use and the occurrence of MetS. Adhering to PRISMA guidelines, we searched MEDLINE, reference lists and journals, using the following search string: ((("Mental Disorders"[Mesh]) AND "Metabolic Syndrome"[Mesh]) AND "Antidepressive Agents"[Mesh]), and retrieved 36 records...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30545140/impact-of-commercial-oenotannin-and-mannoprotein-products-on-the-chemical-and-sensory-properties-of-shiraz-wines-made-from-sequentially-harvested-fruit
#2
Sijing Li, Keren Bindon, Susan Bastian, Kerry Wilkinson
The tannin and polysaccharide profiles and therefore sensory properties of wine are influenced by fruit maturity at harvest, and practices employed during winemaking. This study investigated the extent to which commercial winemaking supplements (skin and seed tannins, and mannoprotein (MP)) can enhance the mouthfeel properties of red wine, in particular, wine made from grapes harvested before commercial ripeness (early-harvest). Supplements were added to wines made from Shiraz grapes harvested at 20.8 and 24...
December 12, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/30543624/ribonuclease-h1-targeted-r-loops-in-surface-antigen-gene-expression-sites-can-direct-trypanosome-immune-evasion
#3
Emma Briggs, Kathryn Crouch, Leandro Lemgruber, Craig Lapsley, Richard McCulloch
Switching of the Variant Surface Glycoprotein (VSG) in Trypanosoma brucei provides a crucial host immune evasion strategy that is catalysed both by transcription and recombination reactions, each operating within specialised telomeric VSG expression sites (ES). VSG switching is likely triggered by events focused on the single actively transcribed ES, from a repertoire of around 15, but the nature of such events is unclear. Here we show that RNA-DNA hybrids, called R-loops, form preferentially within sequences termed the 70 bp repeats in the actively transcribed ES, but spread throughout the active and inactive ES, in the absence of RNase H1, which degrades R-loops...
December 2018: PLoS Genetics
https://www.readbyqxmd.com/read/30541944/screening-and-evaluation-of-fungal-resources-for-loratadine-metabolites
#4
M Keerthana, M Vidyavathi
Loratadine is a selective inverse agonist of peripheral histamine H1-receptors. Microbial biotransformation gained a lot of attention for its ability to convert molecules to valuable medicinally active substances. The main objective of the present research was to investigate the ability of different fungi to biotransform the drug loratadine to its active metabolite desloratadine, because desloratadine is four times more potent, possess longer duration of action than loratadine and is effective at low doses...
December 2018: Journal of Biosciences
https://www.readbyqxmd.com/read/30541779/protein-microarray-analysis-of-the-specificity-and-cross-reactivity-of-influenza-virus-hemagglutinin-specific-antibodies
#5
Rie Nakajima, Medalyn Supnet, Algis Jasinskas, Aarti Jain, Omid Taghavian, Joshua Obiero, Donald K Milton, Wilbur H Chen, Michael Grantham, Richard Webby, Florian Krammer, Darrick Carter, Philip L Felgner, D Huw Davies
Current seasonal influenza virus vaccines engender antibody-mediated protection that is hemagglutinin (HA) subtype specific and relatively short-lived. Coverage for other subtypes or even variants within a subtype could be improved from a better understanding of the factors that promote HA-specific antibody cross-reactivity. Current assays to evaluate cross-reactivity, such as the ELISA, require a separate test for each antigen and are neither high-throughput nor sample-sparing. To address this need, we produced an array of 283 purified HA proteins from influenza A virus subtypes H1 to H16 and H18 and influenza B virus...
December 12, 2018: MSphere
https://www.readbyqxmd.com/read/30537988/hdac-is-indispensable-for-ifn-%C3%AE-induced-b7-h1-expression-in-gastric-cancer
#6
Rui Deng, Peng Zhang, Weizhen Liu, Xiangyu Zeng, Xianxiong Ma, Liang Shi, Tao Wang, Yuping Yin, Weilong Chang, Pei Zhang, Guobin Wang, Kaixiong Tao
BACKGROUND: B7 homolog 1 (B7-H1) overexpression on tumor cells is an important mechanism of immune evasion in gastric cancer (GC). Elucidation of the regulation of B7-H1 expression is urgently required to guide B7-H1-targeted cancer therapy. Interferon gamma (IFN-γ) is thought to be the main driving force behind B7-H1 expression, and epigenetic factors including histone acetylation are recently linked to the process. Here, we investigated the potential role of histone deacetylase (HDAC) in IFN-γ-induced B7-H1 expression in GC...
December 11, 2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/30535591/electrochemical-sandwich-immunoassay-for-insulin-detection-based-on-the-use-of-gold-nanoparticle-modified-mos-2-nanosheets-and-the-hybridization-chain-reaction
#7
Huidan Sun, Shaoyan Wu, Xiaoyan Zhou, Min Zhao, Haiping Wu, Rong Luo, Shijia Ding
A sandwich-type of electrochemical immunoassay is described for the determination of insulin. It is based on the use of a glassy carbon electrode that was modified with MoS2 nanosheets decorated with gold nanoparticles (AuNPs) to immobilize a large amount of first antibody (Ab1 ). Following exposure to insulin, secondary antibody (Ab2 ) that was cross-linked to a DNA initiator strand (T0 ) to form an Ab2 @T0 conjugate was added to undergo a sandwich immunoreaction. Subsequently, the long dsDNA concatemer was formed by a hybridization chain reaction between Ab2 @T0 and auxiliary probes (H1 , H2 )...
December 7, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/30534707/ferroelectric-mesocrystalline-batio-3-babi-4-ti-4-o-15-nanocomposite-formation-mechanism-nanostructure-and-anomalous-ferroelectric-response
#8
Wenxiong Zhang, Sen Li, Hao Ma, Dengwei Hu, Xingang Kong, Shinobu Uemura, Takafumi Kusunose, Qi Feng
Ferroelectric mesocrystalline nanocomposites are promising materials for the enhancement of ferroelectricity via lattice strain engineering due to their high density of heteroepitaxial interfaces. In the present study, a ferroelectric mesocrystalline BaTiO3/BaBi4Ti4O15 (BT/BBT) nanocomposite was synthesized using the layered titanate H1.07Ti1.73O4 via a facile two-step topochemical process. The BT/BBT nanocomposite is constructed from well-aligned BT and BBT nanocrystals oriented along the [110] and [11-1] crystal-axis directions, respectively...
December 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/30534557/a-study-of-machine-learning-classifiers-for-hypertension-based-on-radial-pulse-wave
#9
Zhi-Yu Luo, Ji Cui, Xiao-Juan Hu, Li-Ping Tu, Hai-Dan Liu, Wen Jiao, Ling-Zhi Zeng, Cong-Cong Jing, Li-Jie Qiao, Xu-Xiang Ma, Yu Wang, Jue Wang, Ching-Hsuan Pai, Zhen Qi, Zhi-Feng Zhang, Jia-Tuo Xu
Objective: In this study, machine learning was utilized to classify and predict pulse wave of hypertensive group and healthy group and assess the risk of hypertension by observing the dynamic change of the pulse wave and provide an objective reference for clinical application of pulse diagnosis in traditional Chinese medicine (TCM). Method: The basic information from 450 hypertensive cases and 479 healthy cases was collected by self-developed H20 questionnaires and pulse wave information was acquired by self-developed pulse diagnostic instrument (PDA-1)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30533918/draft-genome-sequence-of-shewanella-algidipiscicola-h1-a-highly-chromate-resistant-strain-isolated-from-mediterranean-marine-sediments
#10
Hiba Baaziz, Olivier N Lemaire, Cécile Jourlin-Castelli, Chantal Iobbi-Nivol, Vincent Méjean, Radia Alatou, Michel Fons
The ability of different Shewanella spp. to convert heavy metals and toxic substances into less toxic products by using them as electron acceptors has led to their use in environmental clean-up strategies. We present here the draft genome sequence of Shewanella algidipiscicola H1, a strain resistant to high concentrations of chromates.
August 2018: Microbiology resource announcements
https://www.readbyqxmd.com/read/30533814/full-genome-sequence-of-thalassotalea-euphylliae-h1-isolated-from-a-montipora-capitata-coral-located-in-hawai-i
#11
Stephen Summers, Marnie L Freckelton, Brian T Nedved, Scott A Rice, Michael G Hadfield
The isolate of Thalassotalea euphylliae H1 was collected from the surface of a Montipora capitata coral. The genome was assembled using long reads from a Nanopore MinION sequencer for scaffolding and complemented with short-read MiSeq sequences. The genome was approximately 4.77 Mb long with 4,020 protein-coding genes, 92 tRNAs, and 22 rRNAs.
November 2018: Microbiology resource announcements
https://www.readbyqxmd.com/read/30532543/activation-of-erk-creb-bdnf-pathway-involved-in-abnormal-behavior-of-neonatally-borna-virus-infected-rats
#12
Chenmeng Li, Xiaoyan Xu, Xiong Zhang, Ke Cheng, Yujie Guo, Jie Jie, Hua Guo, Yong He, Chanjuan Zhou, Siwen Gui, Xiaogang Zhong, Haiyang Wang, Peng Xie
Background: Neuropsychiatric disorders are devastating illnesses worldwide; however, the potential involvement of viruses in the pathophysiological mechanisms of psychiatric diseases have not been clearly elucidated. Borna disease virus (BDV) is a neurotropic, noncytopathic RNA virus. Materials and methods: In this study, we infected neonatal rats intracranially with BDV Hu-H1 and Strain V within 24 hours of birth. Psychological phenotypes were assessed using sucrose preference test, open field test, elevated plus maze test, and forced swim test...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/30530211/a-single-h1-promoter-can-drive-both-guide-rna-and-endonuclease-expression-in-the-crispr-cas9-system
#13
Zongliang Gao, Elena Herrera-Carrillo, Ben Berkhout
The RNA-guided endonuclease Cas9 (CRISPR-Cas9) genome editing system has been widely used for biomedical research and holds great potential for therapeutic applications in eukaryotes. The conventional vector-based CRISPR-Cas9 delivery system requires two different RNA polymerase promoters for expression of the guide RNA (gRNA) and Cas9 endonuclease. The large size and relative complexity of such CRISPR transgene cassettes impede their broad implementation, especially in gene therapy applications with viral vectors that have a limited packaging capacity...
November 1, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30530105/16-%C3%AE-hydroxyestrone-induced-adduct-generate-high-affinity-autoantibodies-in-sle
#14
Wahid Ali Khan
PURPOSE: Increased 16 α-hydroxyestrone (16 α-OHE1 ) and autoantibodies against histone H1 (H1 ) have been well described in systemic lupus erythematosus (SLE), but the combination effects of 16 α-OHE1 and H1 remains unclear. Here, we tried to assess the affinity and binding specificity of SLE autoantibodies against the 16 α-OHE1 -H1 adduct. IgG was induced against this adduct and was also used as immunochemical probe for the estimation of 16 α-OHE1 in the serum of SLE patients. MATERIALS AND METHODS: The affinity and binding specificities of SLE autoantibodies against 16 α-OHE1 -H1 were determined by direct binding and inhibition ELISA as well as quantitative precipitation titration in 60 patients and 30 control subjects...
December 5, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30529997/sperm-and-seminal-plasma-proteomics-of-high-versus-low-fertility-holstein-bulls
#15
R K Kasimanickam, V R Kasimanickam, A Arangasamy, J P Kastelic
Sperm are highly specialized compartmentalized cells, with unique compositional, morphological and functional properties, including a plasma membrane that undergoes dynamic protein remodeling and surface modifications. Seminal plasma is a highly complex biological fluid containing proteins, amino acids, enzymes, fructose and other carbohydrates, lipids, major minerals and trace elements. Seminal plasma proteins are involved in regulation of osmotic pressure and pH of seminal plasma, transport of ions, lipid and hormones...
November 28, 2018: Theriogenology
https://www.readbyqxmd.com/read/30529902/oxaliplatin-5-fluorouracil-and-nab-paclitaxel-as-perioperative-regimen-in-patients-with-resectable-gastric-adenocarcinoma-a-gercor-phase-ii-study-foxagast
#16
S Watson, C de la Fouchardière, S Kim, R Cohen, J B Bachet, C Tournigand, J M Ferraz, M Lefevre, D Colin, M Svrcek, A Meurisse, C Louvet
BACKGROUND: 5-Fluorouracil (5-FU) and platinum-based perioperative chemotherapy is standard of care for resectable gastric adenocarcinoma (RGA). Nanoparticle albumin-bound (Nab-) paclitaxel is active in advanced disease but has never been evaluated in the perioperative setting. The objective was to evaluate the efficacy of Nab-paclitaxel in combination with FOLFOX for RGA patients. METHODS: We performed a non-randomised, open-label, phase II study. RGA patients were assigned to receive neoadjuvant Nab-paclitaxel (150 mg/m2 ) and FOLFOX q2w for six cycles...
December 7, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/30529354/folding-of-poly-amino-acids-and-intrinsically-disordered-proteins-in-overcrowded-milieu-induced-by-ph-change
#17
Alexander V Fonin, Olga V Stepanenko, Asiia K Sitdikova, Iuliia A Antifeeva, Elena I Kostyleva, Alexander M Polyanichko, Maksim M Karasev, Sergey A Silonov, Olga I Povarova, Irina M Kuznetsova, Vladimir N Uversky, Konstantin К Turoverov
pH-induced structural changes of the synthetic homopolypeptides poly-E, poly-K, poly-R, and intrinsically disordered proteins (IDPs) prothymosin α (ProTα) and linker histone H1, in concentrated PEG solutions simulating macromolecular crowding conditions within the membrane-less organelles, were characterized. The conformational transitions of the studied poly-amino acids in the concentrated PEG solutions depend on the polymerization degree of these homopolypeptides, the size of their side chains, the charge distribution of the side chains, and the crowding agent concentration...
December 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30529195/antipsychotic-induced-metabolic-alterations-recounting-the-mechanistic-insights-therapeutic-targets-and-pharmacological-alternatives
#18
REVIEW
Raghunath Singh, Yashika Bansal, Bikash Medhi, Anurag Kuhad
Atypical antipsychotics (AAPs) are the drug of choice in the management of mental illnesses by virtue of their advantage over typical antipsychotics i.e. least tendency of producing extrapyramidal motor symptoms (EPS) or pseudoparkinsonism. Despite the clinical efficacy, AAPs produces troublesome adverse effects, particularly hyperphagia, hyperglycemia, dyslipidemia weight gain, diabetes mellitus, insulin resistance and QT prolongation which further develops metabolic and cardiac complications with subsequent reduction in life expectancy, poor patient compliance, and sudden death...
December 7, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30525563/total-enzyme-syntheses-of-napyradiomycins-a1-and-b1
#19
Shaun McKinnie, Zachary D Miles, Peter A Jordan, Takayoshi Awakawa, Henry P Pepper, Lauren A M Murray, Jonathan H George, Bradley S Moore
The biosynthetic route to the napyradiomycin family of bacterial meroterpenoids has been fully described 32 years following their original isolation and 11 years after their gene cluster discovery. The antimicrobial and cytotoxic natural products napyradiomycins A1 and B1 are produced using three organic substrates (1,3,6,8-tetrahydroxynaphthalene, dimethylallyl pyrophosphate, and geranyl pyrophosphate), and catalysis via five enzymes: two aromatic prenyltransferases (NapT8 and T9); and three vanadium dependent haloperoxidase (VHPO) homologs (NapH1, H3, and H4)...
December 10, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30524315/the-roles-of-e93-and-kr-h1-in-metamorphosis-of-nilaparvata-lugens
#20
Kai Long Li, San Yue Yuan, Satyabrata Nanda, Wei Xia Wang, Feng Xiang Lai, Qiang Fu, Pin Jun Wan
Metamorphosis is a crucial process in insect development. Ecdysone-induced protein 93 (E93) is a determinant that promotes adult metamorphosis in both hemimetabolous and holometabolous insects. Krüppel-homolog 1 (Kr-h1), an early juvenile hormone (JH)-inducible gene, participates in JH signaling pathway controlling insect metamorphosis. In the current study, an E93 cDNA ( NlE93 ) and two Kr-h1 cDNA variants ( NlKr-h1-a and NlKr-h1-b ) were cloned from Nilaparvata lugens (Stål), one of the most destructive hemimetabolous insect pests on rice...
2018: Frontiers in Physiology
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